Use of Functional Magnetic Resonance Imaging (fMRI) to Study Brain Activation in Children With Irritable Bowel Syndrome (fMRI)

Use of Functional Magnetic Resonance Imaging (fMRI) to Study Brain Activation Following Rectal Stimulation in Children With Irritable Bowel Syndrome

The purpose of the study is to map regions of brain activation following rectal stimulation in children with irritable bowel syndrome (IBS) and healthy controls.

Study Overview

• Status: Completed
• Conditions: Irritable Bowel Syndrome

Detailed Description

Our first aim is to compare the brain areas activated rectal stimulation in boys and girls with IBS and healthy children. Our second aim is to compare the anatomic regions of the brain activated during rectal stimulation in pre and post-pubertal male and female subjects between 10-18 yrs of age.

• Study Type: Observational
• Enrollment (Actual): 17

Contacts and Locations

Study Locations

• United States
  • Wisconsin
    • Milwaukee, Wisconsin, United States, 53226
      • Medical College of Wisconsin

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 10 years to 18 years (ADULT, CHILD)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Children will be selected from the Gastroenterology Clinic at Children's Hospital of Wisconsin.

Description

Inclusion Criteria:

• Children aged 10 years to 18 years who provide written assent and whose parents provide written permission for participation
• English-speaking
• Subjects in the IBS group will meet Rome III criteria for IBS as determined by a pediatric gastroenterologist.

Exclusion Criteria:

• Other pain-related diseases, functional gastrointestinal disorders, or somatization disorder
• Mental retardation or pervasive developmental disorder or epilepsy
• Psychosis
• Genetic or chromosomal disorders
• Currently receiving psychoactive drug treatment
• Patients with pacemakers, metal clips used in previous surgery or other device which are not compatible with MRI scanning
• Inability to lie still in the scanner
• Claustrophobia (Inability to lie still in the scanner)
• Pregnancy
• Subjects who admit to substance abuse during screening
• Orthodontic braces

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
IBS; Children between the ages of 10 and 18 who meet Rome III criteria for IBS as determined by a pediatric gastroenterologist.
Control; Healthy children between the ages of 10 and 18.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
We intend to measure the degree of brain activation following rectal stimulation	4 years

Collaborators and Investigators

• Sponsor: Medical College of Wisconsin

Publications and helpful links

General Publications

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Study record dates

Study Major Dates

• Study Start: June 1, 2007
• Primary Completion (ACTUAL): June 1, 2013
• Study Completion (ACTUAL): June 1, 2013

Study Registration Dates

• First Submitted: May 12, 2008
• First Submitted That Met QC Criteria: May 12, 2008
• First Posted (ESTIMATE): May 15, 2008

Study Record Updates

• Last Update Posted (ACTUAL): April 30, 2020
• Last Update Submitted That Met QC Criteria: April 29, 2020
• Last Verified: April 1, 2020

More Information

Terms related to this study

• Keywords: IBS; fMRI; Brain Activation
• Additional Relevant MeSH Terms: Digestive System Diseases; Pathologic Processes; Disease; Gastrointestinal Diseases; Colonic Diseases, Functional; Colonic Diseases; Intestinal Diseases; Syndrome; Irritable Bowel Syndrome
• Other Study ID Numbers: CHW 06/163