Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression

November 20, 2012 updated by: University of Aarhus

Associations Between Depression and Cardiovascular Disease in Patients With Late Onset, Single Episode Major Depressive Disorder

Studies show that depression is a risk factor for the development of coronary artery disease (CAD). Furthermore there is an increased occurrence of depression in patients with CAD. Among other mechanisms atherosclerosis is believed to play a central role regarding these notable associations between depression and CAD. Moreover, patients with late onset major depression have an increased number of small lesions found in the white matter of the brain, the so-called white matter lesions. The main goal of this project is to examine if CAD is associated with depression and/or white matter lesions. CAD is evaluated using coronary CT angiography. Depression is evaluated using a semi-structured diagnostic interview. White matter lesions are quantified using cerebral magnetic resonance.

Study Overview

Status

Completed

Conditions

Study Type

Observational

Enrollment (Actual)

55

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Denmark
      • Aarhus, Denmark, 8200
        • Center of Psychiatric Research, Aarhus University Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

50 years to 70 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Psychiatric treatment facilities (e.g. psychiatric hospital, private psychiatrist).

Description

INCLUSION CRITERIA:

  • Submitted to psychiatric hospital, district psychiatry or private psychiatrist because of major depressive disorder.
  • Meets the criteria for Major Depressive Disorder, Single Episode as defined in the Diagnostic and Statistical Manual, fourth edition (DSM-IV) and the International Classification of Diseases (ICD-10).
  • Age 50-70 years.
  • Written informed consent.
  • Caucasian.

EXCLUSION CRITERIA:

  • Known, or anamnestic/objective signs of, organic brain disease.
  • Organic, including symptomatic, mental disorders as (ICD-10: F00-F09).
  • Dependence syndrome within the last 5 years (ICD-10: F1x.2) or current harmful use (ICD-10: F1x.1) of alcohol or other psychoactive substances.
  • Schizophrenia, schizotypal and delusional disorders (ICD-10: F20-F29).
  • Subject to force of law according to the danish law on psychiatry.
  • Present risk of suicide.
  • Previous cranial trauma resulting in unconsciousness for more than 2 minutes.
  • Medical history of renal failure.
  • Other conditions which contraindicate specific procedures in the project.
  • Other conditions deemed to prevent the subject from completing the examination program.
  • Does not want to participate.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Case-Control
  • Time Perspectives: Cross-Sectional

Cohorts and Interventions

Group / Cohort
Late onset MDD
Patients with major depressive disorder between 50 and 70 years of age that did not suffer from depression before the age of 50.
Controls
Healthy controls (matched for age, sex, and tobacco use status)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Aarhus

Collaborators

Aarhus University Hospital
Vejle Hospital
The Ministry of Science, Technology and Innovation, Denmark
Danish National Research Foundation
Augustinus Fonden

Investigators

  • Study Director: Poul Videbech, Professor, M.D., Dr.Med., Center of Psychiatric Research, Aarhus University Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2009

Study Completion (Actual)

June 1, 2012

Study Registration Dates

First Submitted

January 6, 2009

First Submitted That Met QC Criteria

January 6, 2009

First Posted (Estimate)

January 7, 2009

Study Record Updates

Last Update Posted (Estimate)

November 21, 2012

Last Update Submitted That Met QC Criteria

November 20, 2012

Last Verified

November 1, 2012

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CPF-TAD-1

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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