Phase III Acute Coronary Syndrome (APPRAISE-2)

December 18, 2015 updated by: Bristol-Myers Squibb

Apixaban for Prevention of Acute Ischemic Events - 2 A Phase 3, Randomized, Double-Blind, Evaluation of the Safety and Efficacy of Apixaban In Subjects With a Recent Acute Coronary Syndrome

The purpose of this study is to determine if apixaban is superior to placebo for preventing cardiovascular death, non-fatal myocardial infarction, or ischemic stroke in subjects with a recent acute coronary syndrome

Study Overview

Status

Terminated

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

7484

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Argentina
      • Buenos Aires, Argentina, 1119
        • Local Institution
      • Buenos Aires, Argentina, 1428
        • Local Institution
      • Buenos Aires, Argentina, 1280
        • Local Institution
      • Buenos Aires, Argentina, 1039
        • Local Institution
      • Buenos Aires, Argentina, 1122
        • Local Institution
      • Cordoba, Argentina, 5000
        • Local Institution
      • Cordoba, Argentina, X5004CDT
        • Local Institution
      • Cordoba, Argentina, 5002
        • Local Institution
      • Cordoba, Argentina, 5006
        • Local Institution
      • Corrientes, Argentina, 3400
        • Local Institution
      • Salta, Argentina, A4400ANG
        • Local Institution
      • San Luis, Argentina, D5702JRS
        • Local Institution
      • Santa Fe, Argentina, 3000
        • Local Institution
      • Santa Fe, Argentina, S3000AZG
        • Local Institution
    • Buenos Aires
      • Berazategui, Buenos Aires, Argentina, B1884KZB
        • Local Institution
      • Capital Federal, Buenos Aires, Argentina, 1155
        • Local Institution
      • Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina, 1180
        • Local Institution
      • Ciudad Autonoma De Beunos Aire, Buenos Aires, Argentina, 1431
        • Local Institution
      • Coronel Suarez, Buenos Aires, Argentina, 7540
        • Local Institution
      • Gaba, Buenos Aires, Argentina, 1437
        • Local Institution
      • Haedo, Buenos Aires, Argentina, B1706AJU
        • Local Institution
      • Junin, Buenos Aires, Argentina, 6000
        • Local Institution
      • La Plata, Buenos Aires, Argentina, B1902COS
        • Local Institution
      • Lanus Oeste, Buenos Aires, Argentina, 1824
        • Local Institution
      • Moron, Buenos Aires, Argentina, 1708
        • Local Institution
      • Quilmes, Buenos Aires, Argentina, B1878DKF
        • Local Institution
      • Ramos Mejia, Buenos Aires, Argentina, B1704ETD
        • Local Institution
      • San Isidro, Buenos Aires, Argentina, 1642
        • Local Institution
      • San Martin, Buenos Aires, Argentina, B1650CSQ
        • Local Institution
    • Chaco
      • Resistencia, Chaco, Argentina, 3500
        • Local Institution
    • Cordoba
      • Villa Cabrera, Cordoba, Argentina, 5009
        • Local Institution
      • Villa Carlos Paz, Cordoba, Argentina, 5152
        • Local Institution
      • Villa Maria, Cordoba, Argentina, 5900
        • Local Institution
    • Corrientes
      • Corrientes Capital, Corrientes, Argentina, 3400
        • Local Institution
    • Jujuy
      • San Salvador De Jujuy, Jujuy, Argentina, Y4600ABF
        • Local Institution
    • Mendoza
      • Capital, Mendoza, Argentina, 5500
        • Local Institution
    • Misiones
      • Posadas, Misiones, Argentina, 3300
        • Local Institution
    • Rio Negro
      • Cipolletti, Rio Negro, Argentina, 8324
        • Local Institution
    • Santa Fe
      • Rosario, Santa Fe, Argentina, 2000
        • Local Institution
      • Rosario, Santa Fe, Argentina, 2002
        • Local Institution
    • Tucuman
      • San Miguel De Tucuman, Tucuman, Argentina, 4000
        • Local Institution
      • San Miguel De Tucuman, Tucuman, Argentina, T4000ICL
        • Local Institution
  • Australia
    • Australian Capital Territory
      • Bruce, Australian Capital Territory, Australia, 2617
        • Local Institution
    • New South Wales
      • Broken Hill, New South Wales, Australia, 2880
        • Local Institution
      • Kogarah, New South Wales, Australia, 2217
        • Local Institution
      • Lismore, New South Wales, Australia, 2480
        • Local Institution
    • Queensland
      • Cairns, Queensland, Australia, 4870
        • Local Institution
      • Herston, Queensland, Australia, 4031
        • Local Institution
      • Milton, Queensland, Australia, 4064
        • Local Institution
    • South Australia
      • Ashford, South Australia, Australia, 5035
        • Local Institution
      • Elizabeth Vale, South Australia, Australia, 5112
        • Local Institution
      • Woodville, South Australia, Australia, 5011
        • Local Institution
    • Victoria
      • Fitzroy, Victoria, Australia, 3065
        • Local Institution
      • Geelong, Victoria, Australia, 3220
        • Local Institution
      • Richmond, Victoria, Australia, 3121
        • Local Institution
  • Austria
      • Feldkirch, Austria, 6800
        • Local Institution
      • Graz, Austria, 8036
        • Local Institution
      • Linz, Austria, 4020
        • Local Institution
      • Oberpullendorf, Austria, 7350
        • Local Institution
      • Vienna, Austria, 1090
        • Local Institution
      • Vienna, Austria, 1030
        • Local Institution
      • Wien, Austria, 1090
        • Local Institution
      • Wien, Austria, 1160
        • Local Institution
      • Wien, Austria, 1220
        • Local Institution
  • Belgium
      • Aalst, Belgium, 9300
        • Local Institution
      • Anderlecht, Belgium, 1070
        • Local Institution
      • Antwerpen, Belgium, 2060
        • Local Institution
      • Bonheiden, Belgium, 2820
        • Local Institution
      • Brasschaat, Belgium, 2930
        • Local Institution
      • Brugge, Belgium, 8000
        • Local Institution
      • Gent, Belgium, 9000
        • Local Institution
      • Huy, Belgium, 4500
        • Local Institution
      • Ieper, Belgium, 8900
        • Local Institution
      • Mechelen, Belgium, 2800
        • Local Institution
      • Mol, Belgium, 2400
        • Local Institution
      • Yvoir, Belgium, 5530
        • Local Institution
  • Brazil
      • Rio De Janeiro, Brazil, 22031
        • Local Institution
      • Rio De Janeiro, Brazil, 22240
        • Local Institution
      • Rio De Janeiro, Brazil, 22261
        • Local Institution
      • Sao Paulo, Brazil, 01323
        • Local Institution
      • Sao Paulo, Brazil, 05403
        • Local Institution
      • Sao Paulo, Brazil, 04012
        • Local Institution
      • Sao Paulo, Brazil, 04023
        • Local Institution
      • Sao Paulo, Brazil, 01506
        • Local Institution
      • Sao Paulo, Brazil, 02276
        • Local Institution
      • Sao Paulo, Brazil, 05508
        • Local Institution
    • Alagoas
      • Maceio, Alagoas, Brazil, 57051
        • Local Institution
    • Bahia
      • Salvador, Bahia, Brazil, 40144
        • Local Institution
      • Salvador, Bahia, Brazil, 41810
        • Local Institution
      • Salvador, Bahia, Brazil, 40323
        • Local Institution
      • Salvador, Bahia, Brazil, 41148
        • Local Institution
    • Ceara
      • Sobral, Ceara, Brazil, 62041
        • Local Institution
    • Distrito Federal
      • Brasilia, Distrito Federal, Brazil, 70335
        • Local Institution
      • Brasilia, Distrito Federal, Brazil, 72115
        • Local Institution
      • Brasilia, Distrito Federal, Brazil, 70390
        • Local Institution
      • Brasilia, Distrito Federal, Brazil, 70658
        • Local Institution
    • Goias
      • Goiania, Goias, Brazil, 74809
        • Local Institution
      • Goiania, Goias, Brazil, 74823
        • Local Institution
    • Mato Grosso
      • Juiz De Fora, Mato Grosso, Brazil, 36021
        • Local Institution
    • Minas Gerais
      • Belo Horizonte, Minas Gerais, Brazil, 30110
        • Local Institution
      • Belo Horzonte, Minas Gerais, Brazil, 30150
        • Local Institution
      • Uberlandia, Minas Gerais, Brazil, 38400
        • Local Institution
      • Uberlandia, Minas Gerais, Brazil, 384000-368
        • Local Institution
    • Para
      • Belem, Para, Brazil, 66087
        • Local Institution
    • Parana
      • Curitiba, Parana, Brazil, 80010
        • Local Institution
      • Curitiba, Parana, Brazil, 80730
        • Local Institution
      • Curitiba, Parana, Brazil, 80320
        • Local Institution
      • Londrina, Parana, Brazil, 86010
        • Local Institution
    • Pernambuco
      • Recife, Pernambuco, Brazil, 50100
        • Local Institution
    • Rio De Janeiro
      • Rio Janeiro, Rio De Janeiro, Brazil, 22280
        • Local Institution
    • Rio Grande Do Norte
      • Natal, Rio Grande Do Norte, Brazil, 59020
        • Local Institution
    • Rio Grande Do Sul
      • Passo Fundo, Rio Grande Do Sul, Brazil, 99010
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazil, 90035
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazil, 90610
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazil, 90110
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazil, 90020
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazil, 90620
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazil, 91350
        • Local Institution
    • Santa Catarina
      • Blumenau, Santa Catarina, Brazil, 89010
        • Local Institution
      • Sao Jose, Santa Catarina, Brazil, 88103
        • Local Institution
    • Sao Paulo
      • Campinas, Sao Paulo, Brazil, 13059
        • Local Institution
      • Limeira, Sao Paulo, Brazil, 13480
        • Local Institution
      • Marilia, Sao Paulo, Brazil, 17519
        • Local Institution
      • Marilia, Sao Paulo, Brazil, 17515
        • Local Institution
      • Santo Andre, Sao Paulo, Brazil, 09190
        • Local Institution
      • Santo Andre, Sao Paulo, Brazil, 09020
        • Local Institution
      • Sao Caetano Do Sul, Sao Paulo, Brazil, 09540
        • Local Institution
      • Sao Jose Do Rio Preto, Sao Paulo, Brazil, 15015
        • Local Institution
      • Sao Jose Do Rio Preto, Sao Paulo, Brazil, 15090
        • Local Institution
  • Bulgaria
      • Burgas, Bulgaria, 8000
        • Local Institution
      • Dimitrovgrad, Bulgaria, 6400
        • Local Institution
      • Pazardzhik, Bulgaria, 4400
        • Local Institution
      • Pleven, Bulgaria, 5800
        • Local Institution
      • Plovdiv, Bulgaria, 4002
        • Local Institution
      • Plovdiv, Bulgaria, 4000
        • Local Institution
      • Sofia, Bulgaria, 1202
        • Local Institution
      • Sofia, Bulgaria, 1407
        • Local Institution
      • Sofia, Bulgaria, 1431
        • Local Institution
      • Sofia, Bulgaria, 1527
        • Local Institution
      • Sofia, Bulgaria, 1606
        • Local Institution
      • Sofia, Bulgaria, 1142
        • Local Institution
      • Sofia, Bulgaria, 1233
        • Local Institution
      • Sofia, Bulgaria, 1309
        • Local Institution
      • Sofia, Bulgaria, 1618
        • Local Institution
      • Stara Zagora, Bulgaria, 6003
        • Local Institution
      • Varna, Bulgaria, 9010
        • Local Institution
  • Canada
    • Alberta
      • Edmonton, Alberta, Canada, T6G 2B7
        • Local Institution
      • Edmonton, Alberta, Canada, T5H 3V9
        • Local Institution
      • Edmonton, Alberta, Canada, T6K 4C1
        • Local Institution
    • British Columbia
      • New Westminster, British Columbia, Canada, V3L 3W5
        • Local Institution
      • Penticton, British Columbia, Canada, V2A 3G6
        • Local Institution
      • Victoria, British Columbia, Canada, V8R 4R2
        • Local Institution
    • Manitoba
      • Winnipeg, Manitoba, Canada, R3K 0Y8
        • Local Institution
    • Newfoundland and Labrador
      • St-John, Newfoundland and Labrador, Canada, A1B 3V6
        • Local Institution
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 3A7
        • Local Institution
      • Sydney, Nova Scotia, Canada, B1P 1P3
        • Local Institution
    • Ontario
      • Cambridge, Ontario, Canada, N1R 7R1
        • Local Institution
      • Cambridge, Ontario, Canada, N1R 6V6
        • Local Institution
      • Grimsby, Ontario, Canada, L3M 1P3
        • Local Institution
      • Kitchener, Ontario, Canada, N2M 1B2
        • Local Institution
      • London, Ontario, Canada, N6A 5A5
        • Local Institution
      • Oshawa, Ontario, Canada, L1H 1B9
        • Local Institution
      • Oshawa, Ontario, Canada, L1H 7K4
        • Local Institution
      • Oshawa, Ontario, Canada, L1J2K1
        • Local Institution
      • Parry Sound, Ontario, Canada, P2A 3A4
        • Local Institution
      • Sarnia, Ontario, Canada, N7T 4R9
        • Local Institution
      • Scarborough, Ontario, Canada, M1P 2T7
        • Local Institution
      • Scarborough, Ontario, Canada, M1E 4B9
        • Local Institution
      • Sudbury, Ontario, Canada, P3E 3B8
        • Local Institution
      • Sudbury, Ontario, Canada, P3C 5K7
        • Local Institution
      • Sudbury, Ontario, Canada, P3E 2N8
        • Local Institution
      • Toronto, Ontario, Canada, M5G 2C4
        • Local Institution
      • Toronto, Ontario, Canada, M5B 1W8
        • Local Institution
      • Toronto, Ontario, Canada, M4C 3E7
        • Local Institution
      • Windsor, Ontario, Canada, N8X 1L9
        • Local Institution
    • Quebec
      • Chiccutimi, Quebec, Canada, G7H 5H6
        • Local Institution
      • Levis, Quebec, Canada, G6V 3Z1
        • Local Institution
      • Montreal, Quebec, Canada, H3A 1A1
        • Local Institution
      • Sorel-Tracy, Quebec, Canada, J3P1N5
        • Local Institution
      • St-Foy, Quebec, Canada, G1V 4G5
        • Local Institution
      • St. Charles Borromee, Quebec, Canada, J6E 6J2
        • Local Institution
      • St. Jerome, Quebec, Canada, J7Z 5T3
        • Local Institution
      • Terrebonne, Quebec, Canada, J6V 2H2
        • Local Institution
  • Chile
      • Puerto Montt, Chile
        • Local Institution
    • Araucania
      • Temuco, Araucania, Chile, 4781176
        • Local Institution
    • Biobio
      • Concepcion, Biobio, Chile, 4070038
        • Local Institution
      • Talcahuano, Biobio, Chile, 4270918
        • Local Institution
    • Los Lagos
      • Osorno, Los Lagos, Chile, 5311089
        • Local Institution
    • Magallanes Antartica
      • Punta Arenas, Magallanes Antartica, Chile, 6212296
        • Local Institution
    • Metropolitana
      • Santiago, Metropolitana, Chile
        • Local Institution
      • Santiago, Metropolitana, Chile, 6510031
        • Local Institution
      • Santiago, Metropolitana, Chile, 7650018
        • Local Institution
      • Santiago, Metropolitana, Chile, 8053095
        • Local Institution
      • Santiago, Metropolitana, Chile, 8380000
        • Local Institution
    • Valparaiso
      • Vina Del Mar, Valparaiso, Chile, 2570017
        • Local Institution
  • China
      • Xian, China, 710061
        • Local Institution
    • Beijing
      • Beijing, Beijing, China, 100034
        • Local Institution
      • Beijing, Beijing, China, 100730
        • Local Institution
      • Beijing, Beijing, China, 100044
        • Local Institution
      • Beijing, Beijing, China, 100029
        • Local Institution
      • Beijing, Beijing, China, 100020
        • Local Institution
      • Beijing, Beijing, China, 100038
        • Local Institution
      • Beijing, Beijing, China, 100088
        • Local Institution
      • Beijing, Beijing, China, 100176
        • Local Institution
    • Chongqing
      • Chongqing, Chongqing, China, 400042
        • Local Institution
    • Gansu
      • Lanzhou, Gansu, China, 730030
        • Local Institution
    • Guangdong
      • Guangzhou, Guangdong, China, 510080
        • Local Institution
      • Guangzhou, Guangdong, China, 510120
        • Local Institution
      • Guangzhou, Guangdong, China, 510180
        • Local Institution
      • Guangzhou, Guangdong, China, 510010
        • Local Institution
    • Guangxi
      • Nanning, Guangxi, China, 530021
        • Local Institution
    • Hebei
      • Shijiazhuang, Hebei, China, 710061
        • Local Institution
    • Heilongjiang
      • Harbin, Heilongjiang, China, 150001
        • Local Institution
    • Hubei
      • Wuhan, Hubei, China, 430060
        • Local Institution
    • Hunan
      • Changsha, Hunan, China, 410005
        • Local Institution
    • Jiangsu
      • Nanjing, Jiangsu, China, 210008
        • Local Institution
      • Nanjing, Jiangsu, China, 210009
        • Local Institution
      • Nanjing, Jiangsu, China, 210029
        • Local Institution
      • Suzhou, Jiangsu, China, 215006
        • Local Institution
      • Suzhou, Jiangsu, China, 215004
        • Local Institution
    • Jiangxi
      • Nanchang, Jiangxi, China, 330006
        • Local Institution
    • Jilin
      • Changchun, Jilin, China, 130021
        • Local Institution
      • Changchun, Jilin, China, 130041
        • Local Institution
    • Liaoning
      • Dalian, Liaoning, China, 116023
        • Local Institution
      • Shenyang, Liaoning, China, 110001
        • Local Institution
      • Shenyang, Liaoning, China, 110016
        • Local Institution
      • Shenyang, Liaoning, China, 110004
        • Local Institution
    • Shandong
      • Jinan, Shandong, China, 250012
        • Local Institution
    • Shanghai
      • Beijing, Shanghai, China, 100037
        • Local Institution
      • Shanghai, Shanghai, China, 200072
        • Local Institution
      • Shanghai, Shanghai, China, 200003
        • Local Institution
      • Shanghai, Shanghai, China, 200065
        • Local Institution
    • Sichuan
      • Chengdu, Sichuan, China, 610041
        • Local Institution
      • Chongqing, Sichuan, China, 400010
        • Local Institution
    • Yunnan
      • Kunming, Yunnan, China, 650101
        • Local Institution
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310016
        • Local Institution
      • Hangzhou, Zhejiang, China, 310009
        • Local Institution
  • Colombia
      • Barranquilla, Colombia
        • Local Institution
      • Bogota, Colombia
        • Local Institution
      • Floridablanca, Colombia
        • Local Institution
      • Manizales, Colombia
        • Local Institution
      • Medelin, Colombia
        • Local Institution
      • Medellin, Colombia
        • Local Institution
    • Bolivar
      • Cartagena, Bolivar, Colombia
        • Local Institution
    • Cundinamaral
      • Bogota, Cundinamaral, Colombia
        • Local Institution
    • Valle
      • Cali, Valle, Colombia
        • Local Institution
  • Czech Republic
      • Brno, Czech Republic, 625 00
        • Local Institution
      • Hradec Kralove, Czech Republic, 500 05
        • Local Institution
      • Liberec, Czech Republic, 460 63
        • Local Institution
      • Novy Jicin, Czech Republic, 741 01
        • Local Institution
      • Olomouc, Czech Republic, 77520
        • Local Institution
      • Ostrava, Czech Republic, 728 80
        • Local Institution
      • Praha 10, Czech Republic, 100 34
        • Local Institution
      • Rakovnik, Czech Republic, 269 29
        • Local Institution
      • Usti Nad Orlici, Czech Republic, 562 18
        • Local Institution
  • Denmark
      • Arhus C, Denmark, 8000
        • Local Institution
      • Copenhagen, Denmark, 2100
        • Local Institution
      • Copenhagen, Denmark, 2300
        • Local Institution
      • Copenhagen, Denmark, 2400
        • Local Institution
      • Esbjerg, Denmark, 6700
        • Local Institution
      • Haderslev, Denmark, 6100
        • Local Institution
      • Hellerup, Denmark, 2900
        • Local Institution
      • Hillerod, Denmark, 3400
        • Local Institution
      • Hvidovre, Denmark, 2650
        • Local Institution
      • Naestved, Denmark, 4700
        • Local Institution
      • Silkeborg, Denmark, 8600
        • Local Institution
      • Slagelse, Denmark, 4200
        • Local Institution
  • Finland
      • Espoo, Finland, 02740
        • Local Institution
      • Helsinki, Finland, 00029
        • Local Institution
      • Rovaniemi, Finland, 96101
        • Local Institution
      • Tampere, Finland, 33520
        • Local Institution
  • France
      • Albi Cedex 09, France, 81013
        • Local Institution
      • Amiens Cedex 1, France, 80054
        • Local Institution
      • Avignon, France, 84082
        • Local Institution
      • Cholet, France, 49325
        • Local Institution
      • Lagny Sur Marne, France, 77405
        • Local Institution
      • Langres Cedex, France, 52206
        • Local Institution
      • Montpellier, France, 34000
        • Local Institution
      • Paris Cedex 13, France, 76561
        • Local Institution
      • Pau Universite Cedex, France, 64046
        • Local Institution
      • Strasbourg Cedex, France, 67091
        • Local Institution
      • Toulouse Cedex 03, France, 31076
        • Local Institution
  • Germany
      • Bad Berka, Germany, 99437
        • Local Institution
      • Bad Nauheim, Germany, 61231
        • Local Institution
      • Berlin, Germany, 12351
        • Local Institution
      • Berlin, Germany, 12559
        • Local Institution
      • Berlin, Germany, 13509
        • Local Institution
      • Berlin, Germany, 13585
        • Local Institution
      • Bernau, Germany, 16321
        • Local Institution
      • Bonn, Germany, 53105
        • Local Institution
      • Bonn, Germany, 53115
        • Local Institution
      • Chemnitz, Germany, 09111
        • Local Institution
      • Coswig, Germany, 06869
        • Local Institution
      • Cottbus, Germany, 03048
        • Local Institution
      • Dachau, Germany, 85221
        • Local Institution
      • Essen, Germany, 45122
        • Local Institution
      • Flensburg, Germany, 24939
        • Local Institution
      • Halle/Saale, Germany, 06120
        • Local Institution
      • Hamburg, Germany, 20099
        • Local Institution
      • Hamburg, Germany, 22763
        • Local Institution
      • Hamburg, Germany, 21075
        • Local Institution
      • Hoyerswerda, Germany, 02977
        • Local Institution
      • Jena, Germany, 07747
        • Local Institution
      • Leverkusen, Germany, 51375
        • Local Institution
      • Limburg, Germany, 65549
        • Local Institution
      • Luebeck, Germany, 23538
        • Local Institution
      • Mainz, Germany, 55131
        • Local Institution
      • Muenster, Germany, 48149
        • Local Institution
      • Neuss, Germany, 41464
        • Local Institution
      • Paderborn, Germany, 33098
        • Local Institution
      • Pirna, Germany, 01796
        • Local Institution
      • Regensburg, Germany, 93053
        • Local Institution
      • Rostock, Germany, 18057
        • Local Institution
      • Wesel, Germany, 46483
        • Local Institution
  • Hungary
      • Baja, Hungary, 6500
        • Local Institution
      • Balatonfured, Hungary, 8230
        • Local Institution
      • Budapest, Hungary, 1097
        • Local Institution
      • Budapest, Hungary, 1032
        • Local Institution
      • Budapest, Hungary, 1027
        • Local Institution
      • Budapest, Hungary, 1096
        • Local Institution
      • Budapest, Hungary, 1145
        • Local Institution
      • Budapest, Hungary, 1041
        • Local Institution
      • Budapest, Hungary, 1085
        • Local Institution
      • Budapest, Hungary, 1106
        • Local Institution
      • Budpest, Hungary, 1122
        • Local Institution
      • Cegled, Hungary, 2700
        • Local Institution
      • Debrecen, Hungary, 4032
        • Local Institution
      • Dunaujvaros, Hungary, 2400
        • Local Institution
      • Hodmezovasarhely, Hungary, 6800
        • Local Institution
      • Kecskemet, Hungary, 6000
        • Local Institution
      • Miskolc, Hungary, 3526
        • Local Institution
      • Miskolc, Hungary, 3529
        • Local Institution
      • Szekesfehervar, Hungary, 8000
        • Local Institution
      • Szekszard, Hungary, 7100
        • Local Institution
      • Szentes, Hungary, 6600
        • Local Institution
      • Szombathely, Hungary, 9700
        • Local Institution
      • Zalaegerszeg, Hungary, 8900
        • Local Institution
  • India
      • Bangalore, Karnataka, India, 560034
        • Local Institution
      • Bikaner, India, 334001
        • Local Institution
      • Mangalore, India, 575003
        • Local Institution
      • New Delhi, India, 110025
        • Local Institution
      • New Delhi, India, 110060
        • Local Institution
      • Pune, India, 411004
        • Local Institution
    • Andhra Pradesh
      • Hyderabad, Andhra Pradesh, India, 500-012
        • Local Institution
      • Hyderabad, Andhra Pradesh, India, 500063
        • Local Institution
      • Vijayawada, Andhra Pradesh, India, 520008
        • Local Institution
    • Gujarat
      • Ahmedabad, Gujarat, India, 380006
        • Local Institution
      • Ahmedabad, Gujarat, India, 380015
        • Local Institution
      • Ahmedabad, Gujarat, India, 380014
        • Local Institution
      • Vadodara, Gujarat, India, 390007
        • Local Institution
    • Haryana
      • Gurgaon, Haryana, India, 122001
        • Local Institution
    • Karnataka
      • Bangalore, Karnataka, India, 560054
        • Local Institution
      • Bangalore, Karnataka, India, 560 099
        • Local Institution
      • Mysore, Karnataka, India, 570020
        • Local Institution
      • Shivamogga, Karnataka, India, 577201
        • Local Institution
    • Madhya Pradesh
      • Indore, Madhya Pradesh, India, 452008
        • Local Institution
    • Maharashtra
      • Mumbai, Maharashtra, India, 400007
        • Local Institution
      • Mumbai, Maharashtra, India, 400050
        • Local Institution
      • Nagpur, Maharashtra, India, 440010
        • Local Institution
      • Nagpur, Maharashtra, India, 440012
        • Local Institution
      • Nagpur, Maharashtra, India, 440033
        • Local Institution
      • Pune, Maharashtra, India, 411001
        • Local Institution
    • Maharastra
      • Pune, Maharastra, India, 411004
        • Local Institution
    • Punjab
      • Jalandhar, Punjab, India, 144008
        • Local Institution
    • Rajasthan
      • Jaipur, Rajasthan, India, 302004
        • Local Institution
      • Jaipur, Rajasthan, India, 302017
        • Local Institution
      • Jaipur, Rajasthan, India, 302001
        • Local Institution
    • Tamil Nadu
      • Coimbatore, Tamil Nadu, India, 641037
        • Local Institution
    • Tamilnadu
      • Chennai, Tamilnadu, India, 600081
        • Local Institution
    • Uttar Pradesh
      • Lucknow, Uttar Pradesh, India, 226003
        • Local Institution
  • Israel
      • Afula, Israel, 18101
        • Local Institution
      • Ashkelon, Israel, 78306
        • Local Institution
      • Hadera, Israel, 38100
        • Local Institution
      • Haifa, Israel, 31096
        • Local Institution
      • Haifa, Israel, 31048
        • Local Institution
      • Haifa, Israel, 34362
        • Local Institution
      • Jerusalem, Israel, 91120
        • Local Institution
      • Jerusalem, Israel, 91031
        • Local Institution
      • Jerusalem, Israel, 91240
        • Local Institution
      • Jerusalem, Israel, 91004
        • Local Institution
      • Kfar-Saba, Israel, 44281
        • Local Institution
      • Nahariya, Israel, 22100
        • Local Institution
      • Nazareth, Israel, 16100
        • Local Institution
      • Nazareth, Israel, 16000
        • Local Institution
      • Petach Tikva, Israel, 49100
        • Local Institution
      • Rehovot, Israel, 76100
        • Local Institution
      • Safed, Israel, 13100
        • Local Institution
      • Tel Aviv, Israel, 64239
        • Local Institution
      • Tiberias, Israel, 15208
        • Local Institution
  • Italy
      • Ascoli Piceno, Italy, 63100
        • Local Institution
      • Bergamo, Italy, 24128
        • Local Institution
      • Chieti, Italy, 66013
        • Local Institution
      • Foggia, Italy, 71100
        • Local Institution
      • Gravedona (Co), Italy, 22015
        • Local Institution
      • Grosseto, Italy, 58100
        • Local Institution
      • Massa, Italy, 54100
        • Local Institution
      • Milan, Italy, 20138
        • Local Institution
      • Milano, Italy, 20132
        • Local Institution
      • Naples, Italy, 80131
        • Local Institution
      • Novara, Italy, 28100
        • Local Institution
      • Pavia, Italy, 27100
        • Local Institution
      • Perugia, Italy, 06126
        • Local Institution
      • Roma, Italy, 00184
        • Local Institution
      • San Daniele Del Friuli (Udine), Italy, 33038
        • Local Institution
      • Saronno (Va), Italy, 21047
        • Local Institution
      • Verona, Italy, 37126
        • Local Institution
  • Japan
      • Fukuoka, Japan, 814-0180
        • Local Institution
      • Gifu, Japan, 5008727
        • Local Institution
      • Kochi, Japan, 7808522
        • Local Institution
      • Kumamoto, Japan, 8608556
        • Local Institution
      • Kumamoto, Japan, 8600008
        • Local Institution
      • Kumamoto, Japan, 861-4193
        • Local Institution
      • Kumamoto, Japan, 862-0965
        • Local Institution
      • Kyoto, Japan, 6158087
        • Local Institution
      • Oita, Japan, 870-0263
        • Local Institution
      • Osaka, Japan, 558-8558
        • Local Institution
      • Saga, Japan, 840-8571
        • Local Institution
      • Tokyo, Japan, 1600023
        • Local Institution
    • Aichi
      • Nagoya, Aichi, Japan, 4538511
        • Local Institution
      • Nagoya, Aichi, Japan, 455-8530
        • Local Institution
      • Nagoya, Aichi, Japan, 4668650
        • Local Institution
      • Nagoya-Shi, Aichi, Japan, 4600001
        • Local Institution
      • Seto-Shi, Aichi, Japan, 4898642
        • Local Institution
    • Chiba
      • Matsudo, Chiba, Japan, 2710077
        • Local Institution
    • Fukuoka
      • Kasuga, Fukuoka, Japan, 816-0864
        • Local Institution
      • Kurume, Fukuoka, Japan, 830-8577
        • Local Institution
    • Gifu
      • Gifu-Shi, Gifu, Japan, 5008513
        • Local Institution
      • Ogaki-Shi, Gifu, Japan, 503-8502
        • Local Institution
    • Hiroshima
      • Kure, Hiroshima, Japan, 737-0023
        • Local Institution
    • Hokkaido
      • Obihiro, Hokkaido, Japan, 0808518
        • Local Institution
      • Sapporo, Hokkaido, Japan, 0630005
        • Local Institution
    • Ibaraki
      • Kasama, Ibaraki, Japan, 309-1793
        • Local Institution
      • Tsuchiura-Shi, Ibaraki, Japan, 300-0053
        • Local Institution
      • Tsukuba, Ibaraki, Japan, 3058558
        • Local Institution
    • Ishikawa
      • Kanazawa, Ishikawa, Japan, 9200007
        • Local Institution
    • Kagoshima
      • Kanoya, Kagoshima, Japan, 8930015
        • Local Institution
    • Kanagawa
      • Yokohama, Kanagawa, Japan, 232-0024
        • Local Institution
      • Yokohama, Kanagawa, Japan, 234-8503
        • Local Institution
      • Yokohama Sakae-Ku, Kanagawa, Japan, 247-8581
        • Local Institution
      • Yokosuka, Kanagawa, Japan, 2388567
        • Local Institution
    • Nagano
      • Ueda, Nagano, Japan, 386-8610
        • Local Institution
    • Oita
      • Beppu, Oita, Japan, 874-0011
        • Local Institution
    • Osaka
      • Sakai, Osaka, Japan, 591-8025
        • Local Institution
    • Saga
      • Ureshino, Saga, Japan, 8430393
        • Local Institution
    • Saitama
      • Ageo, Saitama, Japan, 362-8588
        • Local Institution
      • Koshigaya, Saitama, Japan, 3438555
        • Local Institution
      • Toda, Saitama, Japan, 3350023
        • Local Institution
    • Tokushima
      • Komatsushima, Tokushima, Japan, 7738502
        • Local Institution
    • Tokyo
      • Chiyoda-Ku, Tokyo, Japan, 101-8643
        • Local Institution
      • Chuo-Ku, Tokyo, Japan, 1048560
        • Local Institution
      • Hachioji, Tokyo, Japan, 1930998
        • Local Institution
      • Meguro, Tokyo, Japan, 153-8515
        • Local Institution
      • Meguro-Ku, Tokyo, Japan, 1528902
        • Local Institution
    • Yamaguchi
      • Iwakuni, Yamaguchi, Japan, 7408510
        • Local Institution
      • Ube, Yamaguchi, Japan, 7558505
        • Local Institution
  • Korea, Republic of
      • Daegu, Korea, Republic of, 705718
        • Local Institution
      • Goyang, Korea, Republic of, 410-773
        • Local Institution
      • Gwangju, Korea, Republic of, 501-757
        • Local Institution
      • Incheon, Korea, Republic of, 400-711
        • Local Institution
      • Incheon, Korea, Republic of, 405-760
        • Local Institution
      • Jeonbuk, Korea, Republic of, 561-712
        • Local Institution
      • Pusan, Korea, Republic of, 602-739
        • Local Institution
      • Seoul, Korea, Republic of, 138-736
        • Local Institution
      • Seoul, Korea, Republic of, 137-701
        • Local Institution
      • Seoul, Korea, Republic of, 152-703
        • Local Institution
      • Suwon, Korea, Republic of, 443-721
        • Local Institution
    • Gangwon-Do
      • Wonju, Gangwon-Do, Korea, Republic of, 220-701
        • Local Institution
    • Gyeongangnam-Do
      • Yangsan, Gyeongangnam-Do, Korea, Republic of, 626-770
        • Local Institution
    • Gyeonggi-Do
      • Anyang, Gyeonggi-Do, Korea, Republic of, 431-070
        • Local Institution
      • Guri-Si, Gyeonggi-Do, Korea, Republic of, 471-701
        • Local Institution
    • Gyeongsangam-Do
      • Jinju, Gyeongsangam-Do, Korea, Republic of, 660-702
        • Local Institution
  • Mexico
      • Aguascalientes, Mexico, 20230
        • Local Institution
      • Aguascalientes, Mexico, 20127
        • Local Institution
      • Chihuahua, Mexico, 31203
        • Local Institution
      • Durango, Mexico, 34270
        • Local Institution
      • Queretaro, Mexico, 76000
        • Local Institution
      • San Luis Potosi, Mexico, 78240
        • Local Institution
      • Veracruz, Mexico, 91700
        • Local Institution
    • Baja Californa Sur
      • Cabo San Lucas, Baja Californa Sur, Mexico, 23410
        • Local Institution
    • Baja California
      • Tijuana, Baja California, Mexico, 22500
        • Local Institution
    • Coahuila
      • Monclova, Coahuila, Mexico, 25750
        • Local Institution
    • Estado De Mexico
      • Metepec, Estado De Mexico, Mexico, 52140
        • Local Institution
      • Tlalnepantla, Estado De Mexico, Mexico, 54030
        • Local Institution
    • Guerrero
      • Acapulco, Guerrero, Mexico, 39570
        • Local Institution
      • Acapulco, Guerrero, Mexico, 39670
        • Local Institution
    • Hidalgo
      • Pachuca, Hidalgo, Mexico, 42070
        • Local Institution
    • Jalisco
      • Guadalajara, Jalisco, Mexico, 44280
        • Local Institution
      • Guadalajara, Jalisco, Mexico, 44200
        • Local Institution
      • Guadalajara, Jalisco, Mexico, 44210
        • Local Institution
      • Zapopan, Jalisco, Mexico, 45040
        • Local Institution
    • Nuevo Leon
      • Monterrey, Nuevo Leon, Mexico, 64710
        • Local Institution
      • Monterrey, Nuevo Leon, Mexico, 64460
        • Local Institution
      • Monterrey, Nuevo Leon, Mexico, 64060
        • Local Institution
      • Monterrey, Nuevo Leon, Mexico, 64000
        • Local Institution
      • Monterrey, Nuevo Leon, Mexico, 64550
        • Local Institution
    • Sinaloa
      • Culiacan, Sinaloa, Mexico, 80020
        • Local Institution
    • Veracruz
      • Xalapa, Veracruz, Mexico, 91190
        • Local Institution
  • Netherlands
      • Alkmaar, Netherlands, 1815 JD
        • Local Institution
      • Almere, Netherlands, 1315 RA
        • Local Institution
      • Amsterdam, Netherlands, 1091 AC
        • Local Institution
      • Beverwijk, Netherlands, 1942 LE
        • Local Institution
      • Boxmeer, Netherlands, 5831 HA
        • Local Institution
      • Den Haag, Netherlands, 2597 AX
        • Local Institution
      • Dirksland, Netherlands, 3247 BW
        • Local Institution
      • Ede, Netherlands, 6916 RP
        • Local Institution
      • Goes, Netherlands, 4462 RA
        • Local Institution
      • Gouda, Netherlands, 2803 HH
        • Local Institution
      • Heerlen, Netherlands, 6419 PC
        • Local Institution
      • Hilversum, Netherlands, 1213 XZ
        • Local Institution
      • Maastrict, Netherlands, 6229 HX
        • Local Institution
      • Meppel, Netherlands, 7943KA
        • Local Institution
      • Purmerend, Netherlands, 1441 RN
        • Local Institution
      • Sneek, Netherlands, 8601 ZK
        • Local Institution
      • Veldhoven, Netherlands, 5504 DB
        • Local Institution
      • Weert, Netherlands, 6001 BE
        • Local Institution
      • Zwolle, Netherlands, 8011JW
        • Local Institution
  • New Zealand
      • Auckland, New Zealand, 1030
        • Local Institution
      • Auckland, New Zealand, 1640
        • Local Institution
      • Christchurch, New Zealand, 8011
        • Local Institution
      • Hastings, New Zealand, 4120
        • Local Institution
      • Nelson, New Zealand, 7010
        • Local Institution
      • Palmerston North, New Zealand, 4410
        • Local Institution
  • Norway
      • Bergen, Norway, 5021
        • Local Institution
      • Bodo, Norway, 8092
        • Local Institution
      • Drammen, Norway, 3004
        • Local Institution
      • Hamar, Norway, 2318
        • Local Institution
      • Kongsvinger, Norway, 2212
        • Local Institution
      • Kristiansund, Norway, 6508
        • Local Institution
      • Lillehammer, Norway, 2629
        • Local Institution
      • Oslo, Norway, 0407
        • Local Institution
      • Oslo, Norway, 0319
        • Local Institution
      • Oslo, Norway, 0514
        • Local Institution
      • Stavanger, Norway, 4011
        • Local Institution
      • Tynset, Norway, 2500
        • Local Institution
  • Peru
      • Callao, Peru, CALLAO 2
        • Local Institution
      • Cusco, Peru
        • Local Institution
      • Ica, Peru
        • Local Institution
      • Lima, Peru, LIMA 11
        • Local Institution
      • Lima, Peru, LIMA 31
        • Local Institution
      • Lima, Peru, LIMA 13
        • Local Institution
      • Lima, Peru, LIMA 33
        • Local Institution
      • Lima, Peru, LIMA 1
        • Local Institution
      • Lima, Peru, LIMA 41
        • Local Institution
      • Lima, Peru, LIMA 27
        • Local Institution
      • Lima, Peru, LIMA 18
        • Local Institution
      • Lima, Peru, LIMA 39
        • Local Institution
    • Callao
      • Bellavista, Callao, Peru, CALLAO 2
        • Local Institution
    • Lambayeque
      • Chiclayo, Lambayeque, Peru
        • Local Institution
  • Poland
      • Bialystok, Poland, 15-276
        • Local Institution
      • Bydgoszcz, Poland, 85-826
        • Local Institution
      • Bytom, Poland, 41-902
        • Local Institution
      • Czestochowa, Poland, 42-200
        • Local Institution
      • Elblag, Poland, 82-300
        • Local Institution
      • Gdynia, Poland, 81-423
        • Local Institution
      • Grodzisk Mazowiecki, Poland, 05-825
        • Local Institution
      • Inowroclaw, Poland, 88-100
        • Local Institution
      • Kielce, Poland, 25-736
        • Local Institution
      • Koscierzyna, Poland, 83-400
        • Local Institution
      • Krakow, Poland, 31-501
        • Local Institution
      • Krakow, Poland, 31-202
        • Local Institution
      • Lodz, Poland, 91-347
        • Local Institution
      • Lodz, Poland, 91-425
        • Local Institution
      • Lublin, Poland, 20-954
        • Local Institution
      • Lublin, Poland, 20-089
        • Local Institution
      • Opole, Poland, 45-418
        • Local Institution
      • Ostrowiec Swietokrzyski, Poland, 27-400
        • Local Institution
      • Plock, Poland, 09-402
        • Local Institution
      • Poznan, Poland, 60-479
        • Local Institution
      • Radom, Poland, 26617
        • Local Institution
      • Rzeszow, Poland, 35-301
        • Local Institution
      • Slupsk, Poland, 76-200
        • Local Institution
      • Szczecin, Poland, 70-111
        • Local Institution
      • Tarnow, Poland, 33-100
        • Local Institution
      • Torun, Poland, 87-100
        • Local Institution
      • Warsaw, Poland, 02-507
        • Local Institution
      • Warszawa, Poland, 04-628
        • Local Institution
      • Warszawa, Poland, 04-749
        • Local Institution
      • Warszawa, Poland, 01-809
        • Local Institution
      • Wloclawek, Poland, 87-800
        • Local Institution
      • Zabrze, Poland, 41-800
        • Local Institution
      • Zielona Gora, Poland, 65-046
        • Local Institution
    • Mazowiekie
      • Wegrow, Mazowiekie, Poland, 07-100
        • Local Institution
  • Puerto Rico
      • Cidra, Puerto Rico, 00739
        • Local Institution
      • San Juan, Puerto Rico, 00917
        • Local Institution
  • Romania
      • Arad, Romania, 310158
        • Local Institution
      • Baia Mare, Romania, 430031
        • Local Institution
      • Braila, Romania, 810249
        • Local Institution
      • Bucharest, Romania, 050098
        • Local Institution
      • Bucharest, Romania, 021659
        • Local Institution
      • Bucharest, Romania, 011461
        • Local Institution
      • Bucharest, Romania, 042122
        • Local Institution
      • Craiova, Romania, 200642
        • Local Institution
      • Oradea, Romania, 410169
        • Local Institution
      • Pitesti, Romania, 110884
        • Local Institution
      • Sibiu, Romania, 550245
        • Local Institution
      • Targu Mures, Romania, 540136
        • Local Institution
      • Timisoara, Romania, 300736
        • Local Institution
  • Russian Federation
      • Barnaul, Russian Federation, 656055
        • Local Institution
      • Chelyabinsk, Russian Federation, 454136
        • Local Institution
      • Ekaterinburg, Russian Federation, 620109
        • Local Institution
      • Ekaterinburg, Russian Federation, 620144
        • Local Institution
      • Kaluga, Russian Federation, 248007
        • Local Institution
      • Kazan, Russian Federation, 420029
        • Local Institution
      • Kemerovo, Russian Federation, 650002
        • Local Institution
      • Krasnoyarsk, Russian Federation, 660058
        • Local Institution
      • Krasnoyarsk, Russian Federation, 660062
        • Local Institution
      • Moscow, Russian Federation, 109240
        • Local Institution
      • Moscow, Russian Federation, 129327
        • Local Institution
      • Moscow, Russian Federation, 119991
        • Local Institution
      • Moscow, Russian Federation, 105229
        • Local Institution
      • Moscow, Russian Federation, 111539
        • Local Institution
      • Moscow, Russian Federation, 127473
        • Local Institution
      • Moscow, Russian Federation, 121374
        • Local Institution
      • Moscow, Russian Federation, 115093
        • Local Institution
      • Moscow, Russian Federation, 115280
        • Local Institution
      • Moscow, Russian Federation, 117292
        • Local Institution
      • Moscow, Russian Federation, 121359
        • Local Institution
      • Moscow, Russian Federation, 121552
        • Local Institution
      • Moscow, Russian Federation, 117593
        • Local Institution
      • Moscow, Russian Federation, 127018
        • Local Institution
      • Moscow, Russian Federation, 129336
        • Local Institution
      • Moscow, Russian Federation, 125284
        • Local Institution
      • Moscow, Russian Federation, 119620
        • Local Institution
      • Moscow, Russian Federation, 127644
        • Local Institution
      • Moscow, Russian Federation, 129301
        • Local Institution
      • Moscow, Russian Federation, 119048
        • Local Institution
      • Moscow, Russian Federation, 123182
        • Local Institution
      • Moscow, Russian Federation, 125206
        • Local Institution
      • Moscow, Russian Federation, 125424
        • Local Institution
      • Moscow, Russian Federation, 19991
        • Local Institution
      • Moscow Reg. Zhekeznodorozhniy, Russian Federation, 143920
        • Local Institution
      • Nizhni Novgorod, Russian Federation, 603003
        • Local Institution
      • Nizhny Novgorod, Russian Federation, 603005
        • Local Institution
      • Nizhny Novgorod, Russian Federation, 603035
        • Local Institution
      • Novosibirsk, Russian Federation, 630047
        • Local Institution
      • Novosibirsk, Russian Federation, 630008
        • Local Institution
      • Novosibirsk, Russian Federation, 630003
        • Local Institution
      • Novosibirsk, Russian Federation, 630089
        • Local Institution
      • Odintsovo, Russian Federation, 143000
        • Local Institution
      • Penza, Russian Federation, 440026
        • Local Institution
      • Perm, Russian Federation, 614036
        • Local Institution
      • Rostov-On-Don, Russian Federation, 344011
        • Local Institution
      • Ryazan, Russian Federation, 390026
        • Local Institution
      • Saint Petersburg, Russian Federation, 191104
        • Local Institution
      • Saint Petersburg, Russian Federation, 193312
        • Local Institution
      • Saint Petersburg, Russian Federation, 197110
        • Local Institution
      • Saint Petersburg, Russian Federation, 193144
        • Local Institution
      • Saint Petersburg, Russian Federation, 196601
        • Local Institution
      • Saint-Petersburg, Russian Federation, 198205
        • Local Institution
      • Saint-Petersburg, Russian Federation, 198013
        • Local Institution
      • Saint-Petersburg, Russian Federation, 192242
        • Local Institution
      • Saint-Petersburg, Russian Federation, 194156
        • Local Institution
      • Saint-Petersburg, Russian Federation, 195067
        • Local Institution
      • Saratov, Russian Federation, 410028
        • Local Institution
      • Saratov, Russian Federation, 410054
        • Local Institution
      • St. Petersburg, Russian Federation, 194291
        • Local Institution
      • St. Petersburg, Russian Federation, 190000
        • Local Institution
      • St. Petersburg, Russian Federation, 193079
        • Local Institution
      • Tomsk, Russian Federation, 634012
        • Local Institution
      • Tver, Russian Federation, 170036
        • Local Institution
      • Tyumen, Russian Federation, 625023
        • Local Institution
      • Vasilievsky Island, Russian Federation, 199106
        • Local Institution
      • Voronezh, Russian Federation, 394065
        • Local Institution
      • Yaroslavl, Russian Federation, 150062
        • Local Institution
      • Yaroslavl, Russian Federation, 150030
        • Local Institution
      • Yaroslavl, Russian Federation, 150003
        • Local Institution
      • Yaroslavl, Russian Federation, 150002
        • Local Institution
      • Zhukovskiy, Russian Federation, 140180
        • Local Institution
  • Singapore
      • Singapore, Singapore, 768828
        • Local Institution
      • Singapore, Singapore, 168752
        • Local Institution
  • Slovakia
      • Banska Bystrica, Slovakia, 97405
        • Local Institution
      • Bratislava, Slovakia, 833 48
        • Local Institution
      • Kosice, Slovakia, 040 01
        • Local Institution
      • Kosice, Slovakia, 040 11
        • Local Institution
      • Kosice, Slovakia, 04001
        • Local Institution
      • Kralovsky Chlmec, Slovakia, 07701
        • Local Institution
      • Liptovsky Hradok, Slovakia, 033 80
        • Local Institution
      • Lucenec, Slovakia, 984 01
        • Local Institution
      • Martin, Slovakia, 03639
        • Local Institution
      • Nitra, Slovakia, 949 01
        • Local Institution
  • South Africa
      • Johannesburg, South Africa, 2013
        • Local Institution
    • Eastern Cape
      • Port Elizabeth, Eastern Cape, South Africa, 6001
        • Local Institution
      • Port Elizabeth, Eastern Cape, South Africa, 6045
        • Local Institution
    • Free State
      • Bloemfontein, Free State, South Africa, 9301
        • Local Institution
      • Bloemfontein, Free State, South Africa, 9300
        • Local Institution
    • Gauteng
      • Centurion, Gauteng, South Africa, 0157
        • Local Institution
      • Wapadrand - Pretoria, Gauteng, South Africa, 0049
        • Local Institution
    • Kwa Zulu Natal
      • Durban, Kwa Zulu Natal, South Africa, 4091
        • Local Institution
      • Durban, Kwa Zulu Natal, South Africa, 4001
        • Local Institution
      • Durban, Kwa Zulu Natal, South Africa, 4092
        • Local Institution
      • Umhlanga, Kwa Zulu Natal, South Africa, 4321
        • Local Institution
    • Western Cape
      • Bellville, Western Cape, South Africa, 7530
        • Local Institution
      • Kuils River, Western Cape, South Africa, 7580
        • Local Institution
      • Pinelands, Western Cape, South Africa, 7405
        • Local Institution
      • Somerset West, Western Cape, South Africa, 7130
        • Local Institution
      • Worcester, Western Cape, South Africa, 6850
        • Local Institution
  • Spain
      • Almeria, Spain, 04120
        • Local Institution
      • Barcelona, Spain, 08035
        • Local Institution
      • Barcelona, Spain, 08003
        • Local Institution
      • Caceres, Spain, 10003
        • Local Institution
      • El Ejido, Spain, 04700
        • Local Institution
      • Granada, Spain, 18014
        • Local Institution
      • Lleida, Spain, 25198
        • Local Institution
      • Lugo, Spain, 27004
        • Local Institution
      • Madrid, Spain, 28041
        • Local Institution
      • Madrid, Spain, 28050
        • Local Institution
      • Madrid, Spain, 28006
        • Local Institution
      • Madrid, Spain, 28007
        • Local Institution
      • Madrid, Spain, 28046
        • Local Institution
      • Madrid, Spain, 28031
        • Local Institution
      • Malaga, Spain, 29010
        • Local Institution
      • Santiago De Compostela, Spain, 15706
        • Local Institution
      • Sevilla, Spain, 41071
        • Local Institution
      • Tarragona, Spain, 43007
        • Local Institution
      • Torrevieja, Spain, 03186
        • Local Institution
      • Valencia, Spain, 46014
        • Local Institution
      • Valladolid, Spain, 47012
        • Local Institution
      • Zaragoza, Spain, 50009
        • Local Institution
    • Alicante
      • Villajoyosa, Alicante, Spain, 03570
        • Local Institution
    • Asturas
      • Oviedo, Asturas, Spain, 33006
        • Local Institution
    • Gerona
      • Figueres, Gerona, Spain, 17600
        • Local Institution
    • Madrid
      • San Sebastian De Los Reyes, Madrid, Spain, 28702
        • Local Institution
  • Sweden
      • Eskilstuna, Sweden, 631 88
        • Local Institution
      • Halmstad, Sweden, 30185
        • Local Institution
      • Helsingborg, Sweden, 251 87
        • Local Institution
      • Karlskoga, Sweden, 691 81
        • Local Institution
      • Karlstad, Sweden, 651 85
        • Local Institution
      • Koping, Sweden, 731 81
        • Local Institution
      • Lidkoping, Sweden, 531 85
        • Local Institution
      • Molndal, Sweden, 43180
        • Local Institution
      • Skovde, Sweden, 541 85
        • Local Institution
      • Stockholm, Sweden, 141 86
        • Local Institution
      • Stockholm, Sweden, 171 76
        • Local Institution
      • Uppsala, Sweden, 751 85
        • Local Institution
      • Vaxjo, Sweden, 351 85
        • Local Institution
  • Switzerland
      • Geneve, Switzerland, 1211
        • Local Institution
      • St Gallen, Switzerland, 9007
        • Local Institution
      • Zurich, Switzerland, 8091
        • Local Institution
      • Zurich, Switzerland, 8063
        • Local Institution
    • Ticino
      • Lugano, Ticino, Switzerland, 6900
        • Local Institution
  • Turkey
      • Ankara, Turkey, 06100
        • Local Institution
      • Diyarbakir, Turkey, 21280
        • Local Institution
      • Isparta, Turkey, 32100
        • Local Institution
      • Kirikkale, Turkey
        • Local Institution
      • Konya, Turkey, 42080
        • Local Institution
    • Ankara
      • Besevler, Ankara, Turkey, 06500
        • Local Institution
    • Haseki
      • Isanbul, Haseki, Turkey
        • Local Institution
    • Izmir
      • Bornova, Izmir, Turkey, 35100
        • Local Institution
  • Ukraine
      • Chernivtsy, Ukraine, 58013
        • Local Institution
      • Dnipropetrovsk, Ukraine, 49006
        • Local Institution
      • Dnipropetrovsk, Ukraine, 49060
        • Local Institution
      • Donetsk, Ukraine, 83045
        • Local Institution
      • Donetsk, Ukraine, 83003
        • Local Institution
      • Donetsk, Ukraine, 83114
        • Local Institution
      • Ivano-Frankivsk, Ukraine, 76025
        • Local Institution
      • Kharkiv, Ukraine, 61018
        • Local Institution
      • Kharkiv, Ukraine, 61176
        • Local Institution
      • Kharkiv, Ukraine, 61039
        • Local Institution
      • Kharkiv, Ukraine, 61002
        • Local Institution
      • Kharkiv, Ukraine, 61115
        • Local Institution
      • Kyiv, Ukraine, 02091
        • Local Institution
      • Kyiv, Ukraine, 03115
        • Local Institution
      • Kyiv, Ukraine, 03151
        • Local Institution
      • Kyiv, Ukraine, 02660
        • Local Institution
      • Lugansk, Ukraine, 91016
        • Local Institution
      • Lutsk, Ukraine, 43024
        • Local Institution
      • Lviv, Ukraine, 79010
        • Local Institution
      • Lviv, Ukraine, 79015
        • Local Institution
      • Mykolayiv, Ukraine, 54003
        • Local Institution
      • Odessa, Ukraine, 65014
        • Local Institution
      • Odessa, Ukraine, 65059
        • Local Institution
      • Simferopol, Ukraine, 95026
        • Local Institution
      • Vinnitsa, Ukraine, 21029
        • Local Institution
      • Zhaporizhzhya, Ukraine, 69000
        • Local Institution
  • United Kingdom
    • Antrim
      • Belfast, Antrim, United Kingdom, BT9 7AB
        • Local Institution
    • Armagh
      • Belfast, Armagh, United Kingdom, BT12 6BA
        • Local Institution
      • Portadown, Armagh, United Kingdom, BT63 5QQ
        • Local Institution
    • Ayrshire
      • Ayr, Ayrshire, United Kingdom, KA6 6DX
        • Local Institution
      • Kilmarnock, Ayrshire, United Kingdom, KA2 0BE
        • Local Institution
    • Cambridgeshire
      • Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ
        • Local Institution
    • Derbyshire
      • Chesterfield, Derbyshire, United Kingdom, S445BL
        • Local Institution
    • Dumfriesshire
      • Dumfries, Dumfriesshire, United Kingdom, DG1 4AP
        • Local Institution
    • East Yorkshire
      • Cottingham, East Yorkshire, United Kingdom, HU16 5JQ
        • Local Institution
    • Essex
      • Basildon, Essex, United Kingdom, SS16 5NL
        • Local Institution
      • Chelmsford, Essex, United Kingdom, CM1 7ET
        • Local Institution
      • Romford, Essex, United Kingdom, RM7 0AG
        • Local Institution
    • Kent
      • Tunbridge Wells, Kent, United Kingdom, TN4 8AT
        • Local Institution
    • Lancashire
      • Blackpool, Lancashire, United Kingdom, FY3 8NR
        • Local Institution
    • Lincolnshire
      • Scunthorpe, Lincolnshire, United Kingdom, DN15 7BH
        • Local Institution
    • Middlesex
      • Harrow, Middlesex, United Kingdom, HA1 3UJ
        • Local Institution
    • Nottinghamshire
      • Worksop, Nottinghamshire, United Kingdom, S18 0BD
        • Local Institution
    • South Yorkshire
      • Doncaster, South Yorkshire, United Kingdom, DN2 5LT
        • Local Institution
    • Tyne And Wear
      • New Castle Upon Tyne, Tyne And Wear, United Kingdom, NE7 7DN
        • Local Institution
  • United States
    • Alabama
      • Birmingham, Alabama, United States, 35294
        • University of Alabama at Birmingham
      • Birmingham, Alabama, United States, 35294
        • UAB Medical Center
      • Huntsville, Alabama, United States, 35801
        • Heart Center Research, LLC
    • Arizona
      • Phoenix, Arizona, United States, 85020
        • North Phoenix Heart Center
    • Arkansas
      • Fort Smith, Arkansas, United States, 72901
        • Sparks Regional Medical Center
      • Jonesboro, Arkansas, United States, 72401
        • NEA Baptist Clinic
    • California
      • Alameda, California, United States, 94501
        • Phase Care, Llc
      • Anaheim, California, United States, 92801
        • Cardiology Consultants Of Orange County
      • Banning, California, United States, 92220
        • Beaver Medical Group
      • Chula Vista, California, United States, 91911
        • Local Institution
      • Escondido, California, United States, 92025
        • Escondido Cardiology Associates, Inc.
      • Healdsburg, California, United States, 95448
        • William D. Bowden, D.O.
      • Huntington Beach, California, United States, 92648
        • California Heart Specialists, Inc.
      • Laguna Hills, California, United States, 92653
        • Caring Clinical Research Corporation
      • Lakewood, California, United States, 90712
        • Eisenstein, Isaac
      • Long Beach, California, United States, 90806
        • Arvind J. Mehta, Md
      • Los Alamitos, California, United States, 90720
        • Local Institution
      • Los Angeles, California, United States, 90033
        • Preciado Cardiology Incorporated
      • Oakland, California, United States, 94609
        • East Bay Physicians Medical Group
      • Orange, California, United States, 92868
        • St. Joseph Heritage Medical Group
      • Redondo Beach, California, United States, 90277
        • A.R.I. Clinical Trials, Inc.
      • Santa Ana, California, United States, 92704
        • Coastal Multi-Specialty Research
      • Santa Rosa, California, United States, 95405
        • Radiant Research, Inc
      • Torrance, California, United States, 90509
        • Harbbor-Ucla Medical Center
    • Colorado
      • Boulder, Colorado, United States, 80304
        • Rocky Mountain Cardiology
      • Littleton, Colorado, United States, 80120
        • South Denver Cardiology Associates PC
      • Wheat Ridge, Colorado, United States, 80033
        • Drogue Medical, Llc
    • Connecticut
      • Hartford, Connecticut, United States, 06102
        • Hartford Hospital
    • Delaware
      • Newark, Delaware, United States, 19713
        • Alfieri Cardiology
    • Florida
      • Altamonte Springs, Florida, United States, 32714
        • Orlando Heart Specialists
      • Atlantis, Florida, United States, 33462
        • Palm Beach Heart Institute, Llc
      • Clearwater, Florida, United States, 33756
        • The Heart And Vascular Institute Of Florida
      • Clearwater, Florida, United States, 33756
        • Ronald L. Walsh, Do
      • Davie, Florida, United States, 33324
        • Cardiovascular Specialist Of South Florida
      • Ft. Lauderdale, Florida, United States, 33316
        • David E. Perloff, Md
      • Inverness, Florida, United States, 34452
        • Nature Coast Clinical Research
      • Jacksonville, Florida, United States, 32216
        • Jacksonville Center for Clinical Research
      • Jacksonville, Florida, United States, 32223
        • East Coast Institute for Research
      • Jacksonville, Florida, United States, 32207
        • Jacksonville Heart Center, Pa
      • Lake Mary, Florida, United States, 32746
        • The Cardio Vascular Center P.A.
      • Melbourne, Florida, United States, 32901
        • Alpha Medical Research, Llc
      • Melbourne, Florida, United States, 32901
        • Melbourne Internal Medicine Associates (Mima)
      • Miami, Florida, United States, 33175
        • Advanced Pharma Clinical Research
      • Miami, Florida, United States, 33133
        • Glenn J. Barquet, Md
      • Miami, Florida, United States, 33156
        • Miami Cardiology Clinical Research, L.L.C.
      • Miami Beach, Florida, United States, 33140
        • Mount Sinai Medical Center
      • Ocala, Florida, United States, 34471
        • Ocala Research Institute, Inc
      • Ocala, Florida, United States, 34471
        • MediQuest Research Group Inc.
      • Orlando, Florida, United States, 32803
        • Florida Heart Group
      • Orlando, Florida, United States, 32806
        • Orlando Heart Center
      • Palm Beach Gardens, Florida, United States, 33410
        • Palm Beach Gardens Research Center Llc
      • Pembroke Pines, Florida, United States, 33028
        • Local Institution
      • Pensacola, Florida, United States, 32501
        • Cardiology Consultants
      • Pinellas Park, Florida, United States, 33781
        • Advent Clinical Research Centers, Inc.
      • Plantation, Florida, United States, 33317
        • Cardio-Pulmonary Associates
      • Port Orange, Florida, United States, 32127
        • Avivo Clin Clinical Services
      • Sarasota, Florida, United States, 34232
        • Heartcare Research
      • St. Augustine, Florida, United States, 32086
        • St. Augustine Cardiology Associates
      • Tampa, Florida, United States, 33613
        • Dr Kiran C Patel Research Institute At Pepin Heart Hospital
      • Vero Beach, Florida, United States, 32960
        • Howard T. Tee, M.D., F.A.C.P., F.A.C.C.
      • Vero Beach, Florida, United States, 32960
        • Indian River Cardiovascular Associates, Inc
      • Wellington, Florida, United States, 33449
        • Cardiology Partners Clinical Research Institute
    • Georgia
      • Atlanta, Georgia, United States, 30342
        • Cardiovascular Physicians Of North Atlanta
      • Augusta, Georgia, United States, 30912
        • Medical College of Georgia
      • Columbus, Georgia, United States, 31909
        • Columbus Cardiology Associates Pc
      • Covington, Georgia, United States, 30014
        • Georgia Heart Specialists
      • Decatur, Georgia, United States, 30030
        • Atlanta Institute For Medical Research, Inc
      • Duluth, Georgia, United States, 30096
        • In-Quest Medical Research, LLC
      • Dunwoody, Georgia, United States, 30338
        • Alta Pharmaceutical Research Center, Inc.
      • Ellijay, Georgia, United States, 30540
        • North Georgia Medical Research
      • Gainesville, Georgia, United States, 30501
        • Northeast Georgia Heart Cntr, Pc
      • Macon, Georgia, United States, 31201
        • Mercer University School of Medicine
      • Marietta, Georgia, United States, 30060
        • Well Star Cardiovascular Medicine, Pc
      • Riverdale, Georgia, United States, 30274
        • Southern Heart Research Institute, Llc
    • Illinois
      • Carbondale, Illinois, United States, 62901
        • Memorial Hospital of Carbondale
      • Chicago, Illinois, United States, 60611
        • Northwestern University
      • Chicago, Illinois, United States, 60612
        • Rush University Medical Center
      • Chicago, Illinois, United States, 60637
        • University of Chicago Hospitals
      • Gurnee, Illinois, United States, 60031
        • Clinical Investigation Specialists, Inc
      • Jerseyville, Illinois, United States, 62052
        • Gateway Cardiology. P.C
      • Lombard, Illinois, United States, 60148
        • Midwest Heart Foundation
      • Moline, Illinois, United States, 61265
        • Local Institution
      • Normal, Illinois, United States, 61761
        • Illinois Heart & Lung Research
      • Peoria, Illinois, United States, 61614
        • HeartCare Midwest
    • Indiana
      • Elkhart, Indiana, United States, 46514
        • Elkhart Clinic, LLC
      • Hammond, Indiana, United States, 46320
        • St Margaret Mercy Healthcare Centers
      • Indianapolis, Indiana, United States, 46260
        • The Care Group, Llc
      • Indianapolis, Indiana, United States, 46202
        • Krannertt Institute Of Cardiology
      • Indianapolis, Indiana, United States, 46202
        • R. L.Roudebush Va Medical Center
      • Muncie, Indiana, United States, 47303
        • Medical Consultants, Pc
      • Valparaiso, Indiana, United States, 46383
        • Local Institution
    • Iowa
      • Ames, Iowa, United States, 50010
        • McFarland Clinic PC
      • West Des Moines, Iowa, United States, 50266
        • Iowa Heart Center
    • Kansas
      • Overland Park, Kansas, United States, 66209
        • Midwest Cardiology Associates , P.C.
    • Kentucky
      • Ashland, Kentucky, United States, 41101
        • Kentucky Heart & Vascular Physicians
      • Hazard, Kentucky, United States, 41701
        • Local Institution
      • Louisville, Kentucky, United States, 40205
        • Cardiovascular Associates, Psc
      • Owensboro, Kentucky, United States, 42303
        • Research Integrity, LLC
    • Louisiana
      • Alexandria, Louisiana, United States, 71301
        • Alexandria Cardiology Clinic
      • Alexandria, Louisiana, United States, 71301
        • Clinical Research Network
      • New Orleans, Louisiana, United States, 70112
        • Tulane University Hospital and Clinic
      • Shreveport, Louisiana, United States, 71103
        • Louisiana State University Health Sciences Center-Shreveport
      • Shreveport, Louisiana, United States, 71101
        • Overton Brooks V.A.M.C.
      • Slidell, Louisiana, United States, 70458
        • Louisiana Heart Center
    • Maryland
      • Annapolis, Maryland, United States, 21401
        • Local Institution
      • Salisbury, Maryland, United States, 21804
        • Peninsula Cardiology Associates, P.A.
      • Salisbury, Maryland, United States, 21804
        • Delmarva Heart Research Foundation
    • Michigan
      • Alpena, Michigan, United States, 49707
        • Endeavor Medical Research, Plc
      • Detroit, Michigan, United States, 48202
        • Henry Ford Hospital
      • Detroit, Michigan, United States, 48236
        • Local Institution
      • Grand Blanc, Michigan, United States, 48439
        • Genesys Regional Medical Center
      • Lansing, Michigan, United States, 48910
        • Thoracic And Cardiovascular Healthcare Foundation
      • Mt. Pleasant, Michigan, United States, 48858
        • Local Institution
      • Saginaw, Michigan, United States, 48602
        • Covenant Medical Center, Inc
      • St. Joseph, Michigan, United States, 49085
        • Great Lakes Heart & Vascular Institute, Pc
      • Troy, Michigan, United States, 48098
        • William Beaumont Hospital-Troy
    • Minnesota
      • Minneapolis, Minnesota, United States, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, United States, 55417
        • VA Medical Center
      • Minneapolis, Minnesota, United States, 55455
        • University Of Minnesota, Medical School
      • St. Cloud, Minnesota, United States, 56303
        • St Cloud Hospital
    • Mississippi
      • Jackson, Mississippi, United States, 39216
        • University of Mississippi Medical Center
      • Jackson, Mississippi, United States, 49201
        • Local Institution
    • Missouri
      • Columbia, Missouri, United States, 65201
        • Missouri Cardiovascular Specialists
      • St. Louis, Missouri, United States, 63110
        • Washington University School of Medicine
      • St. Louis, Missouri, United States, 63128
        • Gateway Cardiology, P.C.
    • Nebraska
      • Lincoln, Nebraska, United States, 68506
        • BryanLGH Heart Institute
      • Omaha, Nebraska, United States, 68114
        • Heart Consultants
      • Omaha, Nebraska, United States, 68124
        • Alegent Health Clinic Heart & Vascular Specialists
    • New Jersey
      • Brick, New Jersey, United States, 08723
        • Local Institution
      • Elizabeth, New Jersey, United States, 07202
        • Central Jersey Medical Research Center
      • Hamilton, New Jersey, United States, 08690
        • Hamilton Cardiology Associates
      • Linden, New Jersey, United States, 07036
        • Local Institution
      • Ridgewood, New Jersey, United States, 07450
        • The Valley Hospital
      • South Plainfield, New Jersey, United States, 07080
        • Central New Jersey Cardiology
    • New York
      • Brooklyn, New York, United States, 11215
        • New York Methodist Hospital
      • Buffalo, New York, United States, 14203
        • Buffalo General Hospital
      • Massapequa, New York, United States, 11758
        • Dr. Michael Sacher
      • Poughkeepsie, New York, United States, 12601
        • Hudson Valley Heart Center
    • North Carolina
      • Asheville, North Carolina, United States, 28803
        • Asheville Cardiology Associates
      • Chapel Hill, North Carolina, United States, 27599
        • The University of North Carolina at Chapel Hill
      • Durham, North Carolina, United States, 27710
        • Duke University Medical Center
      • Greenville, North Carolina, United States, 27834
        • East Carolina Heart Institute at East Carolina University
      • Raleigh, North Carolina, United States, 27610
        • Wake Med Heart Center
      • Wilmington, North Carolina, United States, 28401
        • Wilmington Medical Research
      • Wilmington, North Carolina, United States, 28403
        • Azalea Research Center
    • North Dakota
      • Fargo, North Dakota, United States, 58122
        • Local Institution
    • Ohio
      • Akron, Ohio, United States, 44304
        • Otfried N. Niedermaier, Md
      • Barberton, Ohio, United States, 44203
        • City Cardiology Associates
      • Cincinnati, Ohio, United States, 45220
        • Cincinnati Veterans Affairs Medical Center
      • Fairfield, Ohio, United States, 45014
        • Fairfield Cardiac Cath Lab, Llc
      • Genoa, Ohio, United States, 43430
        • Genoa Medical Center
      • Middletown, Ohio, United States, 45044
        • Middletown Cardiovascular Associates
      • Toledo, Ohio, United States, 43608
        • Toledo Cardiology Consultants
      • Youngstown, Ohio, United States, 44501
        • Local Institution
      • Zanesville, Ohio, United States, 43701
        • Cardiology Associates Of Southeastern Ohio
    • Oklahoma
      • Bartlesville, Oklahoma, United States, 74006
        • Blue Stem Cardiology
      • Oklahoma City, Oklahoma, United States, 73104
        • University of Oklahoma Health Sciences Center
      • Oklahoma City, Oklahoma, United States, 73103
        • COR Clinical Research, LLC
      • Oklahoma City, Oklahoma, United States, 73109
        • Oklahoma Cardiovascular Associates
    • Oregon
      • Bend, Oregon, United States, 97701
        • St. Charles Health System, Inc.
      • Portland, Oregon, United States, 97225
        • Portland Preventive Cardiology, L.L.C.
    • Pennsylvania
      • Altoona, Pennsylvania, United States, 16602
        • Blair Medical Associates, Inc.
      • Bethlehem, Pennsylvania, United States, 18018
        • St. Lukes Cardiology Associates
      • Erie, Pennsylvania, United States, 16507
        • Hamot Medical Center
      • Erie, Pennsylvania, United States, 16502
        • Consultants In Cardiovascular Diseases, Inc.
      • Johnstown, Pennsylvania, United States, 15905
        • Richard M. Kastelic M.D. & Associates, P.C.
      • Lancaster, Pennsylvania, United States, 17603
        • The Heart Group
      • Philadelphia, Pennsylvania, United States, 19102
        • Drexel University College of Medicine
      • Philadelphia, Pennsylvania, United States, 19104
        • Penn Presbyterian Medical Center
      • Philadelphia, Pennsylvania, United States, 19106
        • Pennsylvania Cardiology Associates
      • Pittsburgh, Pennsylvania, United States, 15240
        • VA Pittsburgh Healthcare System
      • Pottstown, Pennsylvania, United States, 19464
        • Pottstown Medical Specialists, Inc
      • Scranton, Pennsylvania, United States, 18508
        • Local Institution
      • Sellersville, Pennsylvania, United States, 18960
        • Buxmont Cardiology Associates, PC
      • Wormleysburg, Pennsylvania, United States, 17043
        • Moffit Heart & Vascular Group
    • Rhode Island
      • Providence, Rhode Island, United States, 02906
        • The Miriam Hospital
    • South Carolina
      • Anderson, South Carolina, United States, 29621
        • AnMed Health
      • Anderson, South Carolina, United States, 29621
        • Carl Wilson Sofley, Jr., Md
      • Beaufort, South Carolina, United States, 29906
        • Lowcountry Medical Group
      • Columbia, South Carolina, United States, 29204
        • Columbia Cardiology
    • South Dakota
      • Rapid City, South Dakota, United States, 57701
        • Cardiology Assoicates, Pc/Black Hills Clinical Research Ctr
      • Sioux Falls, South Dakota, United States, 57108
        • North Central Heart Institute
    • Tennessee
      • Chattanooga, Tennessee, United States, 37404
        • The Chattanooga Heart Institute
      • Germantown, Tennessee, United States, 38138
        • The Stern Cardiovascular Center, Pa
      • Jackson, Tennessee, United States, 38301
        • Research Associates Of Jackson
      • Johnson City, Tennessee, United States, 37604
        • Mountain State Health Alliance
      • Knoxville, Tennessee, United States, 37916
        • Knoxville Heart Group
      • Nashville, Tennessee, United States, 37203
        • Access Clinical Trials
      • Oak Ridge, Tennessee, United States, 37830
        • Parkway Cardiology Associates, PC
    • Texas
      • Amarillo, Texas, United States, 79106
        • Amarillo Heart Clinical Research Institute Inc.
      • Dallas, Texas, United States, 75216
        • Dallas VA Medical Center
      • Dallas, Texas, United States, 75231
        • Cardiovascular Research Institute of Dallas
      • Dallas, Texas, United States, 75231
        • Heart Consultants Of North Texas
      • Fort Worth, Texas, United States, 76104
        • Texas Health Research & Education Institute
      • Fort Worth, Texas, United States, 76117
        • T&R Clinic
      • Houston, Texas, United States, 77030
        • Methodist DeBakey Heart & Vascular Center
      • Houston, Texas, United States, 77070
        • Northwest Houston Cardiology, Pa
      • Houston, Texas, United States, 77024
        • Med Tech, Inc.
      • Houston, Texas, United States, 77062
        • Centex Research, Pineloch Medical Clinic
      • Houston, Texas, United States, 77070
        • Heart Care Center
      • Lubbock, Texas, United States, 79410
        • Texas Cardiac Center
      • San Antonio, Texas, United States, 78229
        • S.A.M. Clinical Research Center
      • San Antonio, Texas, United States, 78201
        • Central Cardiovascular Institute Of San Antonio
      • San Antonio, Texas, United States, 78201
        • Jose A. Perez, M.D.
      • Sugarland, Texas, United States, 77479
        • Sugarland Cardiology Associates
      • Temple, Texas, United States, 76508
        • Scott&White Memorial Hospital
      • Tomball, Texas, United States, 77375
        • Northwest Heart Center
      • Tyler, Texas, United States, 75701
        • Tyler Cardiovascular Consultants
    • Utah
      • Layton, Utah, United States, 84041
        • Utah Cardiology P.C
    • Virginia
      • Chesapeake, Virginia, United States, 23321
        • Bermisa Family Practice & Research Center
      • Danville, Virginia, United States, 24541
        • Zakhary, Bosh
      • Hopewell, Virginia, United States, 23860
        • Heart Care Associates P.C.
      • Lynchburg, Virginia, United States, 24501
        • The Cardiology Group Centra.
      • Manassas, Virginia, United States, 20109
        • Virginia Cardiolovascular Associates
      • Midlothian, Virginia, United States, 23114
        • Local Institution
      • Norfolk, Virginia, United States, 23507
        • Sendara Cardiovasular Research Institute
      • Richmond, Virginia, United States, 23298
        • Virgina Commonwealth Universitymedical Center
    • Washington
      • Spokane, Washington, United States, 99204
        • Inland Cardiology Associates
      • Tacoma, Washington, United States, 98405
        • Franciscan Research Center
    • Wisconsin
      • Madison, Wisconsin, United States, 53715
        • Dean and St. Mary's Outpatient Center
      • Milwaukee, Wisconsin, United States, 53210
        • Wheaton Franciscan Healthcare St. Joseph

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Acute coronary syndrome (ACS)
  • Clinically stable
  • Receiving standard of care for ACS

Exclusion Criteria:

  • Severe hypertension
  • Active bleeding or high risk for major bleeding
  • Hemoglobin < 9 g/dL

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Placebo Comparator: Placebo
Drug: Placebo
Tablets, Oral, 0 mg, twice daily, until study end
Active Comparator: Apixaban
Drug: Apixaban
Tablets, Oral, 5 mg, twice daily, until study end
Other Names:
  • BSM-562247

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Event Rate of Cardiovascular Death, Myocardial Infarction, or Ischemic Stroke During the Intended Treatment Period - Randomized Participants
Time Frame: Randomization (Day 1) to first event (CV death, MI, ischemic stroke), up to March 2011, approximately 2 years
Event rate was percent of participants with an event of cardiovascular (CV) death, myocardial infarction (MI), or ischemic stroke (number of participants with event/number randomized) per 100 patient (100-pt) years. Study was terminated early and last patient, last visit was in Year 2. Only events confirmed by the adjudication committee were included in the analyses. CV death included deaths due to CV causes (eg, cardiogenic shock, heart failure, arrhythmia/sudden death, cardiac rupture, ischemic stroke, pulmonary embolism, venous/arterial thrombotic events) and other sudden deaths for which an alternative cause was not identified. Intended Treatment Period: the period that started on the day of randomization and ended at the efficacy cut-off date (cut-off date: the date all sites were informed that study drug should be discontinued for all participants, 18 November 2010).
Randomization (Day 1) to first event (CV death, MI, ischemic stroke), up to March 2011, approximately 2 years
Event Rate of Confirmed Major Bleeding Using Thrombolysis in Myocardial Infarction (TIMI) Criteria During the Treatment Period - Treated Participants
Time Frame: From first dose to first occurrence of event (TIMI major bleeding) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years
TIMI Major Bleed Criteria: Fatal bleeding, intracranial hemorrhage, and clinically overt bleeding with a hemoglobin (Hgb) drop of ≥ 5 grams per deciliter (g/dL), or ≥15% absolute decrease in hematocrit. To account for transfusions, Hgb measurements were adjusted for transfusions. A transfusion of 1 unit of blood was assumed to result in an increase by 1 g/dL in Hgb or 3% in hematocrit. Event rate was percent of participants with an event of Major Bleed as per TIMI (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. Treatment Period=events with onset from first dose to last dose plus 2 days.
From first dose to first occurrence of event (TIMI major bleeding) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Event Rate of Unstable Angina (UA) During the Intended Treatment Period - Randomized Participants
Time Frame: Randomization (Day 1) to first event of UA, up to March 2011, approximately 2 years
Unstable Angina (UA) defined as worsening or recurrent severe or repetitive angina symptoms at rest lasting at least 10 minutes with at least 2 of the following: New and dynamic electrocardiogram (ECG) changes; angina symptoms leading to inpatient hospitalization; angina symptoms leading to an unplanned or urgent cardiac catheterization, with or without revascularization, that showed evidence of hemodynamically and clinically significant stenosis. Event rate was percent of participants with an event of unstable angina (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. Intended Treatment Period: the period that started on the day of randomization and ended at the efficacy cut-off date (cut-off date: the date all sites were informed that study drug should be discontinued for all participants, 18 November 2010).
Randomization (Day 1) to first event of UA, up to March 2011, approximately 2 years
Event Rate of Stroke During the Intended Treatment Period - Randomized Participants
Time Frame: Randomization (Day 1) to first event (stroke), up to March 2011, approximately 2 years
Event rate was percent of participants with an event of stroke (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. Diagnosis of stroke required a new, non-traumatic, focal neurological deficit of sudden onset, lasting at least 24 hours that was not due to a readily identifiable non-vascular cause (ie, brain tumor). All strokes were classified as hemorrhagic (documentation on imaging (eg computed tomography scan or magnetic resonance imaging) of hemorrhage in the cerebral parenchyma, or a subdural or subarachnoid hemorrhage), non-hemorrhagic/ischemic stroke, ischemic stroke with hemorrhagic conversion, or type unknown. Intended Treatment Period: the period that started on the day of randomization (Day 1) and ended at the efficacy cut-off date (notification of study termination).
Randomization (Day 1) to first event (stroke), up to March 2011, approximately 2 years
Event Rate of Myocardial Infarction (MI) During the Intended Treatment Period - Randomized Participants
Time Frame: Randomization (Day 1) to first event (MI), up to March 2011, approximately 2 years
MI took into account whether the participant had a recent percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery. Selected key criteria: Elevation of cardiac biomarkers (eg, Creatine Kinase MB fraction (CKMB), Troponin T, Troponin I) above the upper reference limit (URL) plus ischemic symptoms, ECG changes, or imaging evidence of new loss of viable myocardium or new regional wall motion abnormality; Death of CV etiology with new ST-segment elevation or left bundle branch block (LBBB) or fresh intracoronary thrombus by angiography or at autopsy occurring before biomarkers could be obtained or before their appearance in the blood; Following a PCI, elevation of cardiac biomarkers more than 3*URL; Following CABG surgery, elevation of cardiac biomarkers more than 5*URL; New, significant (≥0.04 s) Q waves in ≥2 contiguous leads; Pathologic findings of acute MI. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off notice.
Randomization (Day 1) to first event (MI), up to March 2011, approximately 2 years
Event Rate of Stent Thrombosis During the Intended Treatment Period - Randomized Participants
Time Frame: Randomization (Day 1) to first event (stent thrombosis), up to March 2011, approximately 2 years
Stent thrombosis: Definite stent thrombosis considered to have occurred by either angiographic or pathological confirmation; Probable stent thrombosis considered to have occurred in the following cases: any unexplained death within the first 30 days after stent implantation; irrespective of the time after the procedure, any MI that was related to documented acute ischemia in the territory of the implanted stent without angiographic confirmation of stent thrombosis and in the absence of any other obvious cause; Possible stent thrombosis considered to have occurred with any unexplained death from 30 days after intracoronary stenting until end of study (in Year 2). Event rate was percent of participants with an event of stent thrombosis (number with event/number randomized) per 100-pt years. Only events confirmed by the adjudication committee were included in the analyses. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off notice of study termination.
Randomization (Day 1) to first event (stent thrombosis), up to March 2011, approximately 2 years
Event Rate of Composite of Cardiovascular Death, Myocardial Infarction, Unstable Angina, or Ischemic Stroke During the Intended Treatment Period - Randomized Participants
Time Frame: Randomization (Day 1) to first event (CV death, MI, UA, Ischemic Stroke, up to March 2011, approximately 2 years
Event rate was percent of participants with an event of CV death, MI, unstable angina (UA), or ischemic stroke (number of participants with event/number randomized) per 100-pt years. Only events confirmed by the adjudication committee were included in the analyses. Each type of event was counted once per participant, but participants could have been counted in multiple categories. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off date (notification of study termination).
Randomization (Day 1) to first event (CV death, MI, UA, Ischemic Stroke, up to March 2011, approximately 2 years
Event Rate of Composite of Cardiovascular Death, Fatal Bleed, Myocardial Infarction, or Stroke During the Intended Treatment Period - Randomized Participants
Time Frame: Randomization (Day 1) to first event (CV death, Fatal Bleed, MI, or stroke), up to March 2011, approximately 2 years
Event rate was percent of participants with an event of CV death, fatal bleed, MI, or stroke (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. CV death included deaths due to CV causes; Diagnosis of stroke required a new, non-traumatic, focal neurological deficit of sudden onset, lasting at least 24 hours that was not due to a readily identifiable non-vascular cause; Fatal bleeding defined as bleeding that Adjudication Committee determined was the primary cause of death or contributed directly to death; MI took into account whether the participant had a recent PCI or CABG surgery. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off date (notification of study termination).
Randomization (Day 1) to first event (CV death, Fatal Bleed, MI, or stroke), up to March 2011, approximately 2 years
Event Rate of Composite of All-Cause Death, Myocardial Infarction, or Stroke During the Intended Treatment Period - Randomized Participants
Time Frame: Randomization (Day 1) to first event (All Cause Death, MI, or Stroke), up to March 2011, approximately 2 years

Cause of death was determined by the principal condition that caused the death, not the immediate mode of death.

CV death: included deaths due to CV causes. Non-CV death: included non-CV deaths caused primarily by a malignancy, infection, bleeding, trauma, non-CV system organ failure, or non-CV surgery. Unknown: included deaths that were not attributable to one of the above categories of CV death or to a non-CV cause. MI accounted whether the participant had a recent PCI or CABG surgery. Diagnosis of stroke required a new, non-traumatic, focal neurological deficit of sudden onset, lasting at least 24 hours that was not due to a readily identifiable non-vascular cause. Only events confirmed by the adjudication committee were included in analyses. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off date (notification of study termination).
Randomization (Day 1) to first event (All Cause Death, MI, or Stroke), up to March 2011, approximately 2 years
Event Rate of Confirmed Major Bleeding Using International Society on Thrombosis and Hemostasis (ISTH) Criteria During the Treatment Period - Treated Participants
Time Frame: From first dose to first occurrence of event (ISTH major bleed) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years
ISTH Criteria: Acute clinically overt bleeding defined as new onset, visible bleeding or signs or symptoms suggestive of bleeding confirmed by imaging techniques, which can detect the presence of blood (eg, ultrasound, CT, MRI). Major bleeding: acute clinically overt bleeding accompanied by one or more of the following: A decrease in Hgb of 2 g/dL or more over 24 hours; A transfusion of 2 or more units of packed red blood cells (RBCs); Bleeding that occurs in at least one of the following sites: intracranial, intraspinal, intraocular (within the corpus of the eye; thus, a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, retroperitoneal; Bleeding that was fatal. Bleeding events were adjudicated by the Adjudication Committee. Event rate was percent of participants with an event (number with event/number randomized) per 100-pt years. Treatment Period=events with onset from first dose to last dose plus 2 days.
From first dose to first occurrence of event (ISTH major bleed) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years
Event Rate of Confirmed Major Bleeding or Clinically Relevant Non-Major Bleeding (CRNM) Using ISTH Criteria During the Treatment Period - Treated Participants
Time Frame: From first dose to first occurrence of event (ISTH major or CRNM bleed) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years
ISTH Major bleed: acute clinically overt bleeding accompanied by one or more of the following: A decrease in Hgb of 2 g/dL or more over 24 hours; A transfusion of 2 or more units of packed RBCs; Bleeding that occurs in at least one of the following critical sites: intracranial, intraspinal, intraocular (within the corpus of the eye), pericardial, intra-articular, intramuscular with compartment syndrome, retroperitoneal; Bleeding that was fatal. CRNM: acute clinically overt bleeding that did not satisfy additional criteria required for the bleeding event to be defined as a major bleeding event and meets at least one of the following: Hospital admission for bleeding; Physician guided medical or surgical treatment for bleeding; Change in anti-thrombotic treatment (anticoagulant or antiplatelet) therapy. Bleeding events were adjudicated by the Adjudication Committee. Treatment Period=events with onset from first dose to last dose plus 2 days.
From first dose to first occurrence of event (ISTH major or CRNM bleed) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years
Event Rate of All Bleeding Reported by the Investigator During the Treatment Period - Treated Participants
Time Frame: From first dose to first occurrence of event (Bleeding) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years
Bleeding events were adjudicated by the Adjudication Committee and classified according to Thrombolysis in Myocardial Infarction (TIMI) major, minor, minimal, and International Society on Thrombosis and Hemostasis (ISTH) major and clinically relevant non-major bleeding (CRNM) criteria. The adjudicated results based on TIMI and ISTH classifications, and programmatically identified events (not adjudicated) according to Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) classification were used in the analyses of bleeding endpoints. GUSTO Bleed Criteria included Severe or life-threatening: Intracranial hemorrhage, or bleeding that causes hemodynamic compromise requiring intervention; Moderate: Bleeding that requires a blood transfusion, but does not result in hemodynamic compromise; Mild: Bleeding that does not meet criteria for either severe or moderate bleeding. Treatment Period=events with onset from first dose to last dose plus 2 days.
From first dose to first occurrence of event (Bleeding) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Bristol-Myers Squibb

Collaborators

Pfizer
Duke Clinical Research Institute

Publications and helpful links

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General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2009

Primary Completion (Actual)

March 1, 2011

Study Completion (Actual)

March 1, 2011

Study Registration Dates

First Submitted

January 28, 2009

First Submitted That Met QC Criteria

January 28, 2009

First Posted (Estimate)

January 29, 2009

Study Record Updates

Last Update Posted (Estimate)

January 27, 2016

Last Update Submitted That Met QC Criteria

December 18, 2015

Last Verified

December 1, 2015

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CV185-068
  • EUDRACT# 2008-008298-77

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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