Search clinical trials for: Serine Proteinase Inhibitors

Total 71582 results

Grifols Therapeutics LLC

Terminated

Study to Evaluate the Safety and Efficacy of Liquid Alpha1-Proteinase Inhibitor (Human) in Hospitalized Participants With Coronavirus Disease (COVID-19)

COVID-19

United States, Brazil, Chile, Colombia, Mexico
Shanghai Zhongshan Hospital

Unknown

Protective Effect in Cardiac Surgery Patients

Cardiac Surgery
Institute for Human Genetics and Biochemistry
Grifols Biologicals, LLC; AIDS Community Research Initiative of America

Terminated

Safety and Efficacy of (α1Proteinase Inhibitor, α1PI) in HIV Disease

HIV Disease

United States
Qin Zhang

Completed

Ulinastatin Improves Post-Cardiac Surgery Cognitive Dysfunction

Cardiac Complication

China
Yonsei University

Completed

Effect of Ulinastatin on Postoperative Renal Function in Patients Undergoing Robot-assisted Laparoscopic Partial Nephrectomy

Renal Mass

Korea, Republic of
Sichuan Provincial People's Hospital

Recruiting

Treatment of ARDS With Sivelestat Sodium (TOAWSS)

Acute Respiratory Distress Syndrome

China
University of Edinburgh

Completed

Interaction of Apelin and Angiotensin in the Systemic Circulation

Renin Angiotensin System

United Kingdom
Institute for Human Genetics and Biochemistry
CSL Behring

Completed

Therapy to Elevate CD4 Counts in HIV-1 Disease

HIV Disease

United States
CSL Behring

Completed

Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency

Emphysema | Alpha1-proteinase Inhibitor Deficiency

Australia, Russian Federation, United States, Denmark, Estonia, Finland, Germany, Ireland, Poland, Romania, Sweden, Canada, Czech Republic
Qin Zhang

Recruiting

Ulinastatin Improves and Prevents Cardiac Dysfunction Induced by Cardiopulmonary Bypass

Pharmacological Action

China
Panineeya Mahavidyalaya Institute of Dental Sciences...

Completed

The Association of SERPINA1 Gene Disturbance in Patients With Lung and Gum Disorders (SA1PLG)

Pulmonary Disease, Chronic Obstructive | Generalized Chronic Periodontitis

India
University of Dundee

Recruiting

Bronchiectasis Alpha-1 Augmentation Trial- Modulating Airway Neutrophil Function (BATMAN)

Bronchiectasis Adult

United Kingdom
Baxalta now part of Shire

Completed

GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study

Alpha1-antitrypsin Deficiency

United States, Canada
Baxalta now part of Shire

Terminated

Aralast alpha1-proteinase Inhibitor Surveillance Study

Alpha1-antitrypsin Deficiency

United States
Austin Health
Northern Health and Social Care Trust; Western Hospital, Australia

Unknown

Angiotensin in Septic Kidney Injury Trial (ASK-IT)

Sepsis | Septic Shock | Acute Renal Failure

Australia
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Completed

Alpha 1 Anti-Trypsin (AAT) in Treating Patients With Acute Graft-Versus-Host Disease GVHD)

Graft-Versus-Host Disease (GVHD) Acute on Chronic

United States
Huazhong University of Science and Technology

Not yet recruiting

Effect of Ulinastatin on the Action of NDMRs (Rocuronium / Cisatracurium)

Nondepolarising Muscle Relaxants

China
Medical University of South Carolina
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic Pancreatitis

Chronic Pancreatitis

United States
Kyowa Kirin Co., Ltd.
Japan Blood Products Organization

Completed

KW-3357 Study in Patients With Early Onset Severe Preeclampsia

Preeclampsia

Japan
Baxalta now part of Shire

Completed

Efficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhibitor)

Alpha 1-Antitrypsin Deficiency

New Zealand, Australia
Konkuk University Medical Center

Completed

Ulinastatin's Anti-inflammatory Reaction in Cardiac Surgery (ulistin)

Cardiovascular Disease

Korea, Republic of
Baxalta now part of Shire
Baxter Healthcare, Ltd. (New Zealand), Baxter Healthcare Pty. Ltd. (Australia)

Completed

Pharmacokinetic Study of ARALAST (Human Alpha1- PI)

Alpha 1-Antitrypsin Deficiency

Australia, New Zealand
Baxalta now part of Shire

Completed

GLASSIA Infusion Rate Study

Healthy Volunteers | Alpha1-antitrypsin Deficiency

United States
Yonsei University

Completed

Effects of Ulinastatin on Coagulation in High Risk Patients Undergoing Off Pump Coronary Artery Bypass Graft Surgery

Coronary Artery Occlusive Disease

Korea, Republic of
University of California, San Francisco
La Jolla Pharmaceutical Company

Recruiting

Angiotensin II in Liver Transplantation (AngLT-1)

Liver Transplant; Complications | Vasoplegia

United States
Kamada, Ltd.

Completed

International Study Evaluating the Safety and Efficacy of Inhaled, Human, Alpha-1 Antitrypsin (AAT) in Alpha-1 Antitrypsin Deficient Patients With Emphysema

Emphysema

United Kingdom, Canada, Denmark, Germany, Ireland, Netherlands, Sweden
National Institute of Dental and Craniofacial Research...

Completed

Effects of Topical SLPI on Skin Wounds

Healthy | Wound Healing

United States
Instituto Grifols, S.A.

Completed

Study to Evaluate the Safety and Efficacy of Prolastin in Hospitalized Subjects With COVID-19

COVID-19

Spain
CSL Behring

Completed

Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency.

Emphysema | Alpha 1-proteinase Inhibitor Deficiency

Australia, Canada, Czech Republic, Denmark, Estonia, Finland, Germany, Ireland, Poland, Romania, Sweden
Grifols Therapeutics LLC

Completed

Safety and Pharmacokinetics of Alpha-1 Proteinase Inhibitor in Subjects With Alpha1-Antitrypsin Deficiency (SPARK)

Emphysema | Alpha 1-antitrypsin Deficiency (AATD)

United States
rEVO Biologics

Completed

Pharmacokinetics, Safety and Efficacy Study of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia (PRESERVE-1)

Preeclampsia

United States
The Hospital for Sick Children

Completed

Antithrombin Enhancement May Improve Anticoagulation Efficiency in Infants Undergoing Cardiopulmonary Bypass for Cardiac Surgery

Cardiopulmonary Bypass

Canada
Blessing Corporate Services, Inc
Takeda Pharmaceuticals North America, Inc.

Withdrawn

Aralast NP With Antiviral Treatment and Standard of Care Versus Antiviral Treatment With Standard of Care in Hospitalized Patients With Pneumonia and COVID-19 Infection

Pneumonia, Viral | Covid19

United States
Shire

Withdrawn

ARALAST NP Alpha-1 Lung Density Chronic Obstructive Pulmonary Disease-Emphysema (COPD-E) Study

Chronic Obstructive Pulmonary Disease | Alpha1-antitrypsin Deficiency
Eli Lilly and Company

Completed

A Phase II Study to Determine the Efficacy and Safety of Sivelestat in Subjects With Acute Lung Injury

Acute Lung Injury | Respiratory Distress Syndrome, Adult

United States, Belgium, Spain, Canada, Australia, New Zealand
University of Florence
Azienda Ospedaliero-Universitaria Careggi; Istituto per lo Studio, la Prevenzione...

Recruiting

SLPI for Prostate Cancer

Prostate Cancer | Prostatic Neoplasm

Italy
University of Sao Paulo General Hospital
Fundação de Amparo à Pesquisa do Estado de São Paulo

Completed

Effects of Low Molecular Weight Heparin Versus Dabigatran on Platelet Aggregation in Patients With Stable Coronary Artery Disease

Coronary Disease

Brazil
National Institute of Allergy and Infectious Diseases...
Juvenile Diabetes Research Foundation; Immune Tolerance Network (ITN)

Withdrawn

A Research Trial of Aralast NP in New Onset Diabetes (RETAIN) - Part II (RETAIN)

Diabetes Mellitus, Type 1

United States
Michael Campos, MD
CSL Behring

Completed

Effect of Double Dose of Alpha 1-antitrypsin Augmentation Therapy on Lung Inflammation.

Alpha 1 Antitrypsin Deficiency

United States
Techpool Bio-Pharma Co., Ltd.
Center for ADR Monitoring of Guangdong

Unknown

Post-market Safety Reassessment of Ulinastatin for Injection

Adverse Reaction to Drug

China
Techpool Bio-Pharma Co., Ltd.
The First Affiliated Hospital of Guangzhou Medical University

Unknown

The Safety and Dose Response Relationship of Ulinastatin for Acute Respiratory Distress Syndrome(ARDS)

Acute Respiratory Distress Syndrome

China
CSL Behring

Recruiting

The Safety and Efficacy of Alpha-1 Antitrypsin (AAT) for the Prevention of Graft-Versus-host Disease (GVHD) in Patients Receiving Hematopoietic Cell Transplant (MODULAATE)

Acute-graft-versus-host Disease

United States, Korea, Republic of, Spain, Australia, Germany, Italy, Turkey, Japan
Northwestern University
La Jolla Pharmaceutical Company

Recruiting

Angiotensin II for Distributive Shock

Distributive Shock

United States
Takeda

Withdrawn

A Study of RYMPHYSIA for Alpha1-Proteinase Inhibitor (A1PI) Therapy in Adults With A1PI Deficiency and Chronic Obstructive Pulmonary Disease (COPD)-Emphysema

Chronic Obstructive Pulmonary Disease (COPD) | Alpha1-Antitrypsin Deficiency
Boehringer Ingelheim

Completed

ReAHEAD: A Study to Find Out Whether Education Improves Adherence to Dabigatran in People With Atrial Fibrillation Who Are Younger Than 75 Years

Atrial Fibrillation

Taiwan
Seoul National University Hospital

Recruiting

Perioperative Management of Factor Xa Inhibitors (PERIXA)

Atrial Fibrillation | Anticoagulant-induced Bleeding

Korea, Republic of
Jinnah Postgraduate Medical Centre

Recruiting

Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and Mortality (MUNI-SEP)

Septic Shock | Severe Sepsis | MODS

Pakistan
Nanfang Hospital of Southern Medical University
Dongguan People's Hospital; Foshan Hospital of Traditional Chinese Medicine; Shenzhen... and other collaborators

Recruiting

Effects of Ulinastatin on Inflammatory Response During ECMO Support (Uli-ECMO)

Inflammatory Response | ECMO

China
Yonsei University

Completed

Effects of Ulinastatin on Myocardial Protection and Blood Loss in Patients Undergoing Aortic Valve Replacement

Abnormal Aortic Valve

Korea, Republic of
Centre Hospitalier Universitaire de la Réunion

Completed

Use of Public Health Surveillance Models in the French National Health System Database (DABI-SURV)

Atrial Fibrillation | Anticoagulants | Pharmacoepidemiology

France

Search clinical trials for: Serine Proteinase Inhibitors

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