Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer
October 12, 2023 updated by: National Cancer Institute (NCI)
A Randomized Double-Blinded Phase III Study Comparing Gemcitabine, Cisplatin, and Bevacizumab to Gemcitabine, Cisplatin, and Placebo in Patients With Advanced Transitional Cell Carcinoma
This randomized phase III trial studies gemcitabine hydrochloride, cisplatin, and bevacizumab to see how well they work compared with gemcitabine hydrochloride and cisplatin in treating patients with urinary tract cancer that has spread to other places in the body.
Drugs used in chemotherapy, such as gemcitabine hydrochloride and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Immunotherapy with bevacizumab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread.
It is not yet known whether gemcitabine hydrochloride and cisplatin are more effective when given with or without bevacizumab in treating patients with urinary tract cancer.
Study Overview
Status
Completed
Conditions
- Metastatic Prostate Carcinoma
- Metastatic Bladder Urothelial Carcinoma
- Metastatic Renal Pelvis Urothelial Carcinoma
- Metastatic Ureter Urothelial Carcinoma
- Metastatic Urethral Urothelial Carcinoma
- Metastatic Urothelial Carcinoma
- Stage IV Bladder Urothelial Carcinoma AJCC v7
- Stage IV Renal Pelvis Cancer AJCC v7
- Stage IV Ureter Cancer AJCC v7
- Stage IV Urethral Cancer AJCC v7
- Unresectable Urothelial Carcinoma
- Stage IV Prostate Cancer AJCC v7
- Advanced Urothelial Carcinoma
Detailed Description
PRIMARY OBJECTIVES:
I. To determine if patients with advanced transitional cell carcinoma treated with bevacizumab, gemcitabine hydrochloride (gemcitabine) and cisplatin will have increased overall survival when compared to patients treated with gemcitabine, cisplatin, and placebo.
SECONDARY OBJECTIVES:
I. To compare the progression-free survival of these two regimens in patients with advanced transitional cell carcinoma.
II. To compare the proportion of patients who experience an objective response on each regimen.
III. To compare the grade 3 and greater toxicities in patients treated on the two regimens.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I: Patients receive gemcitabine hydrochloride intravenously (IV) over 30 minutes on days 1 and 8, cisplatin IV, and placebo IV over 30-90 minutes on day 1. Treatment repeats every 21 days for 6 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive placebo IV over 30-90 minutes every 21 days in the absence of disease progression or unacceptable toxicity.
ARM II: Patients receive gemcitabine hydrochloride and cisplatin as in arm I. Patients also receive bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 21 days for 6 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive bevacizumab IV over 30-90 minutes every 21 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up periodically for up to 7 years.
Study Type
Interventional
Enrollment (Actual)
506
Phase
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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San Juan, Puerto Rico, 00936
- San Juan City Hospital
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Alabama
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Birmingham, Alabama, United States, 35233
- University of Alabama at Birmingham Cancer Center
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Mobile, Alabama, United States, 36608
- Providence Hospital
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Alaska
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Fairbanks, Alaska, United States, 99701
- Fairbanks Memorial Hospital
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Arizona
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Tucson, Arizona, United States, 85704
- University of Arizona Cancer Center-Orange Grove Campus
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Tucson, Arizona, United States, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, United States, 85719
- University of Arizona Cancer Center-North Campus
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Arkansas
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Jonesboro, Arkansas, United States, 72401
- Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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Little Rock, Arkansas, United States, 72205
- University of Arkansas for Medical Sciences
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Little Rock, Arkansas, United States, 72205
- John L McClellan Memorial Veterans Hospital
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California
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Berkeley, California, United States, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burlingame, California, United States, 94010
- Mills-Peninsula Medical Center
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Castro Valley, California, United States, 94546
- East Bay Radiation Oncology Center
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Castro Valley, California, United States, 94546
- Valley Medical Oncology Consultants-Castro Valley
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Clovis, California, United States, 93611
- Community Cancer Institute
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Concord, California, United States, 94520
- John Muir Medical Center-Concord Campus
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Emeryville, California, United States, 94608
- Bay Area Breast Surgeons Inc
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Emeryville, California, United States, 94608
- Epic Care Partners in Cancer Care
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Fremont, California, United States, 94538
- Valley Medical Oncology Consultants-Fremont
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Greenbrae, California, United States, 94904
- Marin Cancer Care Inc
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Greenbrae, California, United States, 94904
- Marin General Hospital
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La Jolla, California, United States, 92093
- UC San Diego Moores Cancer Center
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Los Angeles, California, United States, 90033
- USC / Norris Comprehensive Cancer Center
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Los Angeles, California, United States, 90033
- Los Angeles County-USC Medical Center
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Martinez, California, United States, 94553-3156
- Contra Costa Regional Medical Center
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Modesto, California, United States, 95355
- Memorial Medical Center
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Mountain View, California, United States, 94040
- El Camino Hospital
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Mountain View, California, United States, 94040
- Palo Alto Medical Foundation-Camino Division
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Northridge, California, United States, 91325
- Northridge Hospital Medical Center
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Novato, California, United States, 94945
- Sutter Cancer Research Consortium
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Oakland, California, United States, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, United States, 94609
- Hematology and Oncology Associates-Oakland
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Oakland, California, United States, 94602
- Highland General Hospital
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Oakland, California, United States, 94609
- Tom K Lee Inc
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Oakland, California, United States, 94609
- Bay Area Tumor Institute
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Orange, California, United States, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
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Orange, California, United States, 92868
- Saint Joseph Hospital - Orange
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Palo Alto, California, United States, 94304
- Stanford Cancer Institute Palo Alto
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Palo Alto, California, United States, 94301
- Palo Alto Medical Foundation Health Care
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Pasadena, California, United States, 91105
- Keck Medical Center of USC Pasadena
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Pleasanton, California, United States, 94588
- Valley Care Health System - Pleasanton
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Pleasanton, California, United States, 94588
- Valley Medical Oncology Consultants
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Saint Helena, California, United States, 94574
- Saint Helena Hospital
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Salinas, California, United States, 93901
- Salinas Valley Memorial
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San Francisco, California, United States, 94115
- California Pacific Medical Center-Pacific Campus
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San Francisco, California, United States, 94115
- UCSF Medical Center-Mount Zion
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San Pablo, California, United States, 94806
- Doctors Medical Center- JC Robinson Regional Cancer Center
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Santa Cruz, California, United States, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Rosa, California, United States, 95403
- Sutter Pacific Medical Foundation
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Sunnyvale, California, United States, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Vallejo, California, United States, 94589
- Sutter Solano Medical Center/Cancer Center
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Walnut Creek, California, United States, 94598
- John Muir Medical Center-Walnut Creek
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Colorado
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Alamosa, Colorado, United States, 81101
- San Luis Valley Regional Medical Center
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Aurora, Colorado, United States, 80045
- University of Colorado Hospital
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Aurora, Colorado, United States, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, United States, 80012
- The Medical Center of Aurora
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Aurora, Colorado, United States, 80045
- Rocky Mountain Regional VA Medical Center
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Boulder, Colorado, United States, 80301
- Boulder Community Hospital
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Boulder, Colorado, United States, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, United States, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, United States, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, United States, 80210
- Porter Adventist Hospital
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Denver, Colorado, United States, 80217-3364
- University of Colorado
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Denver, Colorado, United States, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, United States, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, United States, 80218
- SCL Health Saint Joseph Hospital
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Denver, Colorado, United States, 80220
- Rose Medical Center
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Denver, Colorado, United States, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, United States, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, United States, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, United States, 80222
- Western States Cancer Research NCORP
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Durango, Colorado, United States, 81301
- Mercy Medical Center
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Durango, Colorado, United States, 81301
- Southwest Oncology PC
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Edwards, Colorado, United States, 81632
- Shaw Cancer Center
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Englewood, Colorado, United States, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, United States, 80113
- Swedish Medical Center
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Fort Collins, Colorado, United States, 80524
- Poudre Valley Hospital
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Glenwood Springs, Colorado, United States, 81601
- Valley View Hospital Cancer Center
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Golden, Colorado, United States, 80401
- Mountain Blue Cancer Care Center
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Grand Junction, Colorado, United States, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, United States, 80631
- North Colorado Medical Center
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Greenwood Village, Colorado, United States, 80111
- Rocky Mountain Cancer Centers-Greenwood Village
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Lafayette, Colorado, United States, 80026
- Kaiser Permanente-Rock Creek
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Lakewood, Colorado, United States, 80228
- Saint Anthony Hospital
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Lakewood, Colorado, United States, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Littleton, Colorado, United States, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, United States, 80122
- Littleton Adventist Hospital
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Lone Tree, Colorado, United States, 80124
- Kaiser Permanente-Lone Tree
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Lone Tree, Colorado, United States, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, United States, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, United States, 80501
- Longmont United Hospital
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Longmont, Colorado, United States, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, United States, 80539
- McKee Medical Center
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Montrose, Colorado, United States, 81401
- Montrose Memorial Hospital
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Parker, Colorado, United States, 80138
- Parker Adventist Hospital
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Parker, Colorado, United States, 80138
- Rocky Mountain Cancer Centers-Parker
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Pueblo, Colorado, United States, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, United States, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, United States, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, United States, 80229
- North Suburban Medical Center
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Wheat Ridge, Colorado, United States, 80033
- SCL Health Lutheran Medical Center
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Connecticut
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Danbury, Connecticut, United States, 06810
- Danbury Hospital
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Farmington, Connecticut, United States, 06030
- University of Connecticut
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Greenwich, Connecticut, United States, 06830
- Greenwich Hospital
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Hartford, Connecticut, United States, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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Hartford, Connecticut, United States, 06102
- Hartford Hospital
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Manchester, Connecticut, United States, 06040
- Manchester Memorial Hospital
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Meriden, Connecticut, United States, 06451
- Midstate Medical Center
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New Haven, Connecticut, United States, 06520
- Yale University
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Norwalk, Connecticut, United States, 06856
- Norwalk Hospital
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Norwich, Connecticut, United States, 06360
- Eastern Connecticut Hematology and Oncology Associates
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Stamford, Connecticut, United States, 06904
- Stamford Hospital/Bennett Cancer Center
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Delaware
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Lewes, Delaware, United States, 19958
- Beebe Medical Center
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Newark, Delaware, United States, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, United States, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, United States, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, United States, 19718
- Christiana Care Health System-Christiana Hospital
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Newark, Delaware, United States, 19713
- Christiana Gynecologic Oncology LLC
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Rehoboth Beach, Delaware, United States, 19971
- Beebe Health Campus
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Seaford, Delaware, United States, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, United States, 19801
- Christiana Care Health System-Wilmington Hospital
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District of Columbia
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Washington, District of Columbia, United States, 20010
- MedStar Washington Hospital Center
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Washington, District of Columbia, United States, 20007
- MedStar Georgetown University Hospital
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Washington, District of Columbia, United States, 20016
- Sibley Memorial Hospital
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Florida
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Altamonte Springs, Florida, United States, 32701
- AdventHealth Altamonte
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Fort Lauderdale, Florida, United States, 33308
- Holy Cross Hospital
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Jupiter, Florida, United States, 33458
- Jupiter Medical Center
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Kissimmee, Florida, United States, 34744
- AdventHealth Kissimmee
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Miami Beach, Florida, United States, 33140
- Mount Sinai Medical Center
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Orlando, Florida, United States, 32806
- Orlando Health Cancer Institute
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Orlando, Florida, United States, 32803
- AdventHealth Orlando
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Orlando, Florida, United States, 32803
- AdventHealth Medical Group Urology at Orlando
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Orlando, Florida, United States, 32822
- AdventHealth East Orlando
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Weston, Florida, United States, 33331
- Cleveland Clinic-Weston
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Winter Park, Florida, United States, 32792
- AdventHealth Winter Park
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Georgia
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Atlanta, Georgia, United States, 30342
- Emory Saint Joseph's Hospital
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Atlanta, Georgia, United States, 30309
- Piedmont Hospital
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Atlanta, Georgia, United States, 30342
- Northside Hospital
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Atlanta, Georgia, United States, 30342
- Atlanta Regional CCOP
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Austell, Georgia, United States, 30106
- WellStar Cobb Hospital
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Columbus, Georgia, United States, 31904
- John B Amos Cancer Center
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Decatur, Georgia, United States, 30033
- Dekalb Medical Center
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Fayetteville, Georgia, United States, 30214
- Piedmont Fayette Hospital
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Gainesville, Georgia, United States, 30501
- Northeast Georgia Medical Center-Gainesville
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Lawrenceville, Georgia, United States, 30046
- Northside Hospital - Gwinnett
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Macon, Georgia, United States, 31201
- Medical Center of Central Georgia
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Marietta, Georgia, United States, 30060
- WellStar Kennestone Hospital
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Riverdale, Georgia, United States, 30274
- Southern Regional Medical Center
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Rome, Georgia, United States, 30165
- Harbin Clinic Medical Oncology and Clinical Research
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Savannah, Georgia, United States, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, United States, 31404
- Memorial Health University Medical Center
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Hawaii
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'Aiea, Hawaii, United States, 96701
- Pali Momi Medical Center
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'Aiea, Hawaii, United States, 96701
- Queen's Cancer Center - Pearlridge
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Honolulu, Hawaii, United States, 96813
- Queen's Medical Center
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Honolulu, Hawaii, United States, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, United States, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, United States, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, United States, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, United States, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, United States, 96826
- Kapiolani Medical Center for Women and Children
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Kailua, Hawaii, United States, 96734
- Castle Medical Center
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Lihue, Hawaii, United States, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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Idaho
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Boise, Idaho, United States, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, United States, 83712
- Saint Luke's Cancer Institute - Boise
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Fruitland, Idaho, United States, 83619
- Saint Luke's Cancer Institute - Fruitland
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Lewiston, Idaho, United States, 83501
- Saint Joseph Regional Medical Center
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Meridian, Idaho, United States, 83642
- Idaho Urologic Institute-Meridian
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Meridian, Idaho, United States, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, United States, 83686
- Saint Luke's Cancer Institute - Nampa
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Post Falls, Idaho, United States, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Twin Falls, Idaho, United States, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Alton, Illinois, United States, 62002
- Saint Anthony's Health
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Aurora, Illinois, United States, 60504
- Rush - Copley Medical Center
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Bloomington, Illinois, United States, 61704
- Illinois CancerCare-Bloomington
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Bloomington, Illinois, United States, 61701
- Saint Joseph Medical Center
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Canton, Illinois, United States, 61520
- Illinois CancerCare-Canton
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Canton, Illinois, United States, 61520
- Graham Hospital Association
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Carbondale, Illinois, United States, 62902
- Memorial Hospital of Carbondale
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Carthage, Illinois, United States, 62321
- Illinois CancerCare-Carthage
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Carthage, Illinois, United States, 62321
- Memorial Hospital
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Centralia, Illinois, United States, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, United States, 60611
- Northwestern University
-
Chicago, Illinois, United States, 60637
- University of Chicago Comprehensive Cancer Center
-
Chicago, Illinois, United States, 60611
- Hematology and Oncology Associates
-
Danville, Illinois, United States, 61832
- Carle on Vermilion
-
Decatur, Illinois, United States, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, United States, 62526
- Cancer Care Specialists of Illinois - Decatur
-
Decatur, Illinois, United States, 62526
- Heartland Cancer Research NCORP
-
Effingham, Illinois, United States, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, United States, 62401
- Carle Physician Group-Effingham
-
Elmhurst, Illinois, United States, 60126
- Elmhurst Memorial Hospital
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Eureka, Illinois, United States, 61530
- Illinois CancerCare-Eureka
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Eureka, Illinois, United States, 61530
- Eureka Hospital
-
Galesburg, Illinois, United States, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, United States, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, United States, 60134
- Northwestern Medicine Cancer Center Delnor
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Havana, Illinois, United States, 62644
- Mason District Hospital
-
Havana, Illinois, United States, 62644
- Illinois CancerCare-Havana
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Highland Park, Illinois, United States, 60035
- Hematology Oncology Associates of Illinois-Highland Park
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Hines, Illinois, United States, 60141
- Edward Hines Jr VA Hospital
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Joliet, Illinois, United States, 60432
- Midwest Center for Hematology Oncology
-
Kankakee, Illinois, United States, 60901
- Presence Saint Mary's Hospital
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Kewanee, Illinois, United States, 61443
- Illinois CancerCare-Kewanee Clinic
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La Grange, Illinois, United States, 60525
- AMITA Health Adventist Medical Center
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Libertyville, Illinois, United States, 60048
- AMG Libertyville - Oncology
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Macomb, Illinois, United States, 61455
- Illinois CancerCare-Macomb
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Macomb, Illinois, United States, 61455
- Mcdonough District Hospital
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Mattoon, Illinois, United States, 61938
- Carle Physician Group-Mattoon/Charleston
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Maywood, Illinois, United States, 60153
- Loyola University Medical Center
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Monmouth, Illinois, United States, 61462
- Illinois CancerCare-Monmouth
-
Monmouth, Illinois, United States, 61462
- Holy Family Medical Center
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Mount Vernon, Illinois, United States, 62864
- Good Samaritan Regional Health Center
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New Lenox, Illinois, United States, 60451
- UC Comprehensive Cancer Center at Silver Cross
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Niles, Illinois, United States, 60714
- Illinois Cancer Specialists-Niles
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Normal, Illinois, United States, 61761
- Carle Cancer Institute Normal
-
Normal, Illinois, United States, 61761
- Bromenn Regional Medical Center
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Normal, Illinois, United States, 61761
- Illinois CancerCare-Community Cancer Center
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Ottawa, Illinois, United States, 61350
- Illinois CancerCare-Ottawa Clinic
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Ottawa, Illinois, United States, 61350
- Radiation Oncology of Northern Illinois
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Ottawa, Illinois, United States, 61350
- Ottawa Regional Hospital and Healthcare Center
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Pekin, Illinois, United States, 61554
- Illinois CancerCare-Pekin
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Pekin, Illinois, United States, 61554
- OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
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Peoria, Illinois, United States, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, United States, 61637
- OSF Saint Francis Medical Center
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Peoria, Illinois, United States, 61615
- Illinois CancerCare-Peoria
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Peoria, Illinois, United States, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
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Peoria, Illinois, United States, 61614
- Proctor Hospital
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Peru, Illinois, United States, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, United States, 61354
- Valley Radiation Oncology
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Peru, Illinois, United States, 61354
- Illinois Valley Hospital
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Princeton, Illinois, United States, 61356
- Illinois CancerCare-Princeton
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Princeton, Illinois, United States, 61356
- Perry Memorial Hospital
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Rockford, Illinois, United States, 61114
- SwedishAmerican Regional Cancer Center/ACT
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Rockford, Illinois, United States, 61104
- Swedish American Hospital
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Skokie, Illinois, United States, 60076
- Hematology Oncology Associates of Illinois - Skokie
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Spring Valley, Illinois, United States, 61362
- Illinois CancerCare-Spring Valley
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Springfield, Illinois, United States, 62781
- Memorial Medical Center
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Urbana, Illinois, United States, 61801
- Carle Cancer Center
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Urbana, Illinois, United States, 61801
- The Carle Foundation Hospital
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Warrenville, Illinois, United States, 60555
- Northwestern Medicine Cancer Center Warrenville
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Yorkville, Illinois, United States, 60560
- Rush-Copley Healthcare Center
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Indiana
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Beech Grove, Indiana, United States, 46107
- Franciscan Saint Francis Health-Beech Grove
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Carmel, Indiana, United States, 46032
- IU Health North Hospital
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Elkhart, Indiana, United States, 46515
- Elkhart General Hospital
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Elkhart, Indiana, United States, 46514
- Michiana Hematology Oncology PC-Elkhart
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Elkhart, Indiana, United States, 46514-2098
- Elkhart Clinic
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Fort Wayne, Indiana, United States, 46845
- Fort Wayne Medical Oncology and Hematology Inc-Parkview
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Indianapolis, Indiana, United States, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
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Indianapolis, Indiana, United States, 46202
- Sidney and Lois Eskenazi Hospital
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Indianapolis, Indiana, United States, 46202
- Richard L. Roudebush Veterans Affairs Medical Center
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Kokomo, Indiana, United States, 46904
- Community Howard Regional Health
-
La Porte, Indiana, United States, 46350
- IU Health La Porte Hospital
-
Lafayette, Indiana, United States, 47904
- IU Health Arnett Cancer Care
-
Merrillville, Indiana, United States, 46410
- Premier Oncology Hematology Associates
-
Michigan City, Indiana, United States, 46360
- Franciscan Saint Anthony Health-Michigan City
-
Michigan City, Indiana, United States, 46360
- Woodland Cancer Care Center
-
Mishawaka, Indiana, United States, 46545
- Michiana Hematology Oncology PC-Mishawaka
-
Mishawaka, Indiana, United States, 46545
- Saint Joseph Regional Medical Center-Mishawaka
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Muncie, Indiana, United States, 47303
- IU Health Ball Memorial Hospital
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Plymouth, Indiana, United States, 46563
- Michiana Hematology Oncology PC-Plymouth
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Richmond, Indiana, United States, 47374
- Reid Health
-
South Bend, Indiana, United States, 46601
- Memorial Hospital of South Bend
-
South Bend, Indiana, United States, 46601
- Michiana Hematology Oncology PC-South Bend
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South Bend, Indiana, United States, 46628
- Northern Indiana Cancer Research Consortium
-
South Bend, Indiana, United States, 46617
- South Bend Clinic
-
Westville, Indiana, United States, 46391
- Michiana Hematology Oncology PC-Westville
-
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Iowa
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Ames, Iowa, United States, 50010
- McFarland Clinic PC - Ames
-
Ames, Iowa, United States, 50010
- Mary Greeley Medical Center
-
Bettendorf, Iowa, United States, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
-
Boone, Iowa, United States, 50036
- McFarland Clinic PC-Boone
-
Cedar Rapids, Iowa, United States, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, United States, 52403
- Oncology Associates at Mercy Medical Center
-
Cedar Rapids, Iowa, United States, 52402
- Saint Luke's Hospital
-
Cedar Rapids, Iowa, United States, 52402
- Physicians' Clinic of Iowa PC
-
Clive, Iowa, United States, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, United States, 50325
- Medical Oncology and Hematology Associates-West Des Moines
-
Council Bluffs, Iowa, United States, 51503
- Alegent Health Mercy Hospital
-
Des Moines, Iowa, United States, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, United States, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, United States, 50309
- Medical Oncology and Hematology Associates-Des Moines
-
Des Moines, Iowa, United States, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, United States, 50309
- Iowa-Wide Oncology Research Coalition NCORP
-
Des Moines, Iowa, United States, 50314
- Medical Oncology and Hematology Associates-Laurel
-
Des Moines, Iowa, United States, 50307
- Mercy Capitol
-
Fort Dodge, Iowa, United States, 50501
- McFarland Clinic PC-Trinity Cancer Center
-
Iowa City, Iowa, United States, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
Iowa City, Iowa, United States, 52246
- Iowa City VA Healthcare System
-
Jefferson, Iowa, United States, 50129
- McFarland Clinic PC-Jefferson
-
Marshalltown, Iowa, United States, 50158
- McFarland Clinic PC-Marshalltown
-
Mason City, Iowa, United States, 50401
- Mercy Medical Center - North Iowa
-
Ottumwa, Iowa, United States, 52501
- Ottumwa Regional Health Center
-
Sioux City, Iowa, United States, 51101
- Siouxland Regional Cancer Center
-
Sioux City, Iowa, United States, 51102
- Mercy Medical Center-Sioux City
-
Sioux City, Iowa, United States, 51104
- Saint Luke's Regional Medical Center
-
West Des Moines, Iowa, United States, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, United States, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, United States, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, United States, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, United States, 67042
- Cancer Center of Kansas - El Dorado
-
Emporia, Kansas, United States, 66801
- Newman Regional Health
-
Fort Scott, Kansas, United States, 66701
- Cancer Center of Kansas - Fort Scott
-
Garden City, Kansas, United States, 67846
- Saint Catherine Hospital
-
Great Bend, Kansas, United States, 67530
- Saint Rose Ambulatory and Surgery Center
-
Hays, Kansas, United States, 67601
- HaysMed University of Kansas Health System
-
Hutchinson, Kansas, United States, 67502
- Hutchinson Regional Medical Center
-
Independence, Kansas, United States, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, United States, 66160
- University of Kansas Cancer Center
-
Kansas City, Kansas, United States, 66112
- University of Kansas Cancer Center-West
-
Kansas City, Kansas, United States, 66112
- Providence Medical Center
-
Kingman, Kansas, United States, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, United States, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, United States, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, United States, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, United States, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, United States, 67114
- Cancer Center of Kansas - Newton
-
Overland Park, Kansas, United States, 66210
- University of Kansas Cancer Center-Overland Park
-
Overland Park, Kansas, United States, 66209
- Menorah Medical Center
-
Overland Park, Kansas, United States, 66213
- Saint Luke's South Hospital
-
Parsons, Kansas, United States, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, United States, 66762
- Ascension Via Christi - Pittsburg
-
Prairie Village, Kansas, United States, 66208
- Kansas City NCI Community Oncology Research Program
-
Pratt, Kansas, United States, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, United States, 67401
- Salina Regional Health Center
-
Salina, Kansas, United States, 67401
- Cancer Center of Kansas - Salina
-
Shawnee Mission, Kansas, United States, 66204
- Advent Health - Shawnee Mission Medical Center
-
Topeka, Kansas, United States, 66606
- University of Kansas Health System Saint Francis Campus
-
Wellington, Kansas, United States, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, United States, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, United States, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, United States, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, United States, 67208
- Associates In Womens Health
-
Wichita, Kansas, United States, 67214
- Wichita NCI Community Oncology Research Program
-
Wichita, Kansas, United States, 67214
- Wesley Medical Center
-
Winfield, Kansas, United States, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown, Kentucky, United States, 40004
- Flaget Memorial Hospital
-
Lexington, Kentucky, United States, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, United States, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, United States, 40509
- Saint Joseph Hospital East
-
Louisville, Kentucky, United States, 40202
- Jewish Hospital
-
Louisville, Kentucky, United States, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, United States, 40215
- Saints Mary and Elizabeth Hospital
-
Louisville, Kentucky, United States, 40215
- Doctors Carrol, Sheth, Raghavan
-
Owensboro, Kentucky, United States, 42303
- Owensboro Health Mitchell Memorial Cancer Center
-
Shepherdsville, Kentucky, United States, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, United States, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, United States, 70809
- Ochsner Health Center-Summa
-
Baton Rouge, Louisiana, United States, 70806
- Baton Rouge General Medical Center
-
Metairie, Louisiana, United States, 70006
- Robert Veith MD LLC
-
New Orleans, Louisiana, United States, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, United States, 70112
- University Medical Center New Orleans
-
New Orleans, Louisiana, United States, 70112
- Louisiana State University Health Science Center
-
-
Maine
-
Augusta, Maine, United States, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, United States, 04401
- Eastern Maine Medical Center
-
Scarborough, Maine, United States, 04074
- Maine Center for Cancer Medicine-Scarborough
-
-
Maryland
-
Baltimore, Maryland, United States, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
-
Baltimore, Maryland, United States, 21201
- University of Maryland/Greenebaum Cancer Center
-
Baltimore, Maryland, United States, 21201
- Veterans Administration Medical Center-Baltimore
-
Elkton, Maryland, United States, 21921
- Christiana Care - Union Hospital
-
Rockville, Maryland, United States, 20850
- Maryland Oncology Hematology PA-Aquilino Cancer Center
-
-
Massachusetts
-
Boston, Massachusetts, United States, 02215
- Beth Israel Deaconess Medical Center
-
Boston, Massachusetts, United States, 02215
- Dana-Farber Cancer Institute
-
Boston, Massachusetts, United States, 02115
- Brigham and Women's Hospital
-
Boston, Massachusetts, United States, 02114
- Massachusetts General Hospital Cancer Center
-
Brighton, Massachusetts, United States, 02135
- Steward Saint Elizabeth's Medical Center
-
Methuen, Massachusetts, United States, 01844
- Holy Family Hospital
-
Norwood, Massachusetts, United States, 02062
- Norwood Hospital
-
Springfield, Massachusetts, United States, 01199
- Baystate Medical Center
-
Worcester, Massachusetts, United States, 01655
- UMass Memorial Medical Center - University Campus
-
-
Michigan
-
Adrian, Michigan, United States, 49221
- Bixby Medical Center
-
Adrian, Michigan, United States, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, United States, 48106
- Saint Joseph Mercy Hospital
-
Ann Arbor, Michigan, United States, 48106
- Michigan Cancer Research Consortium NCORP
-
Battle Creek, Michigan, United States, 49017
- Bronson Battle Creek
-
Big Rapids, Michigan, United States, 49307
- Spectrum Health Big Rapids Hospital
-
Dearborn, Michigan, United States, 48124
- Beaumont Hospital - Dearborn
-
Detroit, Michigan, United States, 48202
- Henry Ford Hospital
-
Detroit, Michigan, United States, 48236
- Ascension Saint John Hospital
-
Escanaba, Michigan, United States, 49829
- Green Bay Oncology - Escanaba
-
Flint, Michigan, United States, 48532
- Genesys Regional Medical Center-West Flint Campus
-
Flint, Michigan, United States, 48503
- Hurley Medical Center
-
Flint, Michigan, United States, 48503
- Genesys Hurley Cancer Institute
-
Grand Rapids, Michigan, United States, 49503
- Spectrum Health at Butterworth Campus
-
Grand Rapids, Michigan, United States, 49503
- Mercy Health Saint Mary's
-
Grand Rapids, Michigan, United States, 49503
- Cancer Research Consortium of West Michigan NCORP
-
Iron Mountain, Michigan, United States, 49801
- Green Bay Oncology - Iron Mountain
-
Jackson, Michigan, United States, 49201
- Allegiance Health
-
Kalamazoo, Michigan, United States, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, United States, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, United States, 49048
- Borgess Medical Center
-
Lansing, Michigan, United States, 48912
- Sparrow Hospital
-
Livonia, Michigan, United States, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Marquette, Michigan, United States, 49855
- UP Health System Marquette
-
Monroe, Michigan, United States, 48162
- Mercy Memorial Hospital
-
Monroe, Michigan, United States, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Muskegon, Michigan, United States, 49444
- Mercy Health Mercy Campus
-
Niles, Michigan, United States, 49120
- Lakeland Hospital Niles
-
Pontiac, Michigan, United States, 48341
- Saint Joseph Mercy Oakland
-
Port Huron, Michigan, United States, 48060
- Lake Huron Medical Center
-
Reed City, Michigan, United States, 49677
- Spectrum Health Reed City Hospital
-
Royal Oak, Michigan, United States, 48073
- William Beaumont Hospital-Royal Oak
-
Saginaw, Michigan, United States, 48601
- Ascension Saint Mary's Hospital
-
Saint Joseph, Michigan, United States, 49085
- Lakeland Medical Center Saint Joseph
-
Saint Joseph, Michigan, United States, 49085
- Marie Yeager Cancer Center
-
Traverse City, Michigan, United States, 49684
- Munson Medical Center
-
Warren, Michigan, United States, 48093
- Saint John Macomb-Oakland Hospital
-
-
Minnesota
-
Alexandria, Minnesota, United States, 56308
- Medini, Eitan MD (UIA Investigator)
-
Bemidji, Minnesota, United States, 56601
- Sanford Joe Lueken Cancer Center
-
Burnsville, Minnesota, United States, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, United States, 55433
- Mercy Hospital
-
Duluth, Minnesota, United States, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, United States, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, United States, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, United States, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, United States, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, United States, 55432
- Unity Hospital
-
Hutchinson, Minnesota, United States, 55350
- Hutchinson Area Health Care
-
Maplewood, Minnesota, United States, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, United States, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, United States, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, United States, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, United States, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, United States, 55455
- University of Minnesota/Masonic Cancer Center
-
New Ulm, Minnesota, United States, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, United States, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, United States, 55905
- Mayo Clinic in Rochester
-
Saint Cloud, Minnesota, United States, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Cloud, Minnesota, United States, 56303
- Saint Cloud Hospital
-
Saint Louis Park, Minnesota, United States, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, United States, 55416
- Metro Minnesota Community Oncology Research Consortium
-
Saint Paul, Minnesota, United States, 55101
- Regions Hospital
-
Saint Paul, Minnesota, United States, 55102
- United Hospital
-
Shakopee, Minnesota, United States, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, United States, 55082
- Lakeview Hospital
-
Waconia, Minnesota, United States, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, United States, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, United States, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Mississippi
-
Hattiesburg, Mississippi, United States, 39401
- Hattiesburg Clinic - Hematology/Oncology Clinic
-
Hattiesburg, Mississippi, United States, 39404
- Forrest General Hospital / Cancer Center
-
Jackson, Mississippi, United States, 39216
- University of Mississippi Medical Center
-
-
Missouri
-
Bolivar, Missouri, United States, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, United States, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, United States, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, United States, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, United States, 63703
- Southeast Cancer Center
-
Columbia, Missouri, United States, 65212
- University of Missouri - Ellis Fischel
-
Columbia, Missouri, United States, 65201
- Veterans Administration
-
Independence, Missouri, United States, 64057
- Centerpoint Medical Center LLC
-
Jefferson City, Missouri, United States, 65109
- Capital Region Southwest Campus
-
Joplin, Missouri, United States, 64804
- Freeman Health System
-
Joplin, Missouri, United States, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, United States, 64128
- Kansas City Veterans Affairs Medical Center
-
Kansas City, Missouri, United States, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, United States, 64116
- North Kansas City Hospital
-
Kansas City, Missouri, United States, 64131
- The University of Kansas Cancer Center-South
-
Kansas City, Missouri, United States, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, United States, 64132
- Research Medical Center
-
Kansas City, Missouri, United States, 64108
- Truman Medical Centers
-
Kansas City, Missouri, United States, 64118
- Heartland Hematology and Oncology Associates Incorporated
-
Kansas City, Missouri, United States, 64114
- Saint Joseph Health Center
-
Lee's Summit, Missouri, United States, 64064
- University of Kansas Cancer Center - Lee's Summit
-
Lee's Summit, Missouri, United States, 64086
- Saint Luke's East - Lee's Summit
-
Liberty, Missouri, United States, 64068
- Liberty Radiation Oncology Center
-
Rolla, Missouri, United States, 65401
- Delbert Day Cancer Institute at PCRMC
-
Rolla, Missouri, United States, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Saint Joseph, Missouri, United States, 64506
- Heartland Regional Medical Center
-
Saint Joseph, Missouri, United States, 64507
- Saint Joseph Oncology Inc
-
Saint Louis, Missouri, United States, 63110
- Washington University School of Medicine
-
Saint Louis, Missouri, United States, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, United States, 63141
- Mercy Hospital Saint Louis
-
Saint Louis, Missouri, United States, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Saint Louis, Missouri, United States, 63141
- Saint Louis-Cape Girardeau CCOP
-
Saint Louis, Missouri, United States, 63104
- SSM Health Saint Louis University Hospital
-
Saint Louis, Missouri, United States, 63141
- Center for Cancer Care and Research
-
Saint Louis, Missouri, United States, 63141
- Comprehensive Cancer Care PC
-
Sainte Genevieve, Missouri, United States, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, United States, 65804
- Cancer Research for the Ozarks NCORP
-
Springfield, Missouri, United States, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, United States, 65804
- Mercy Hospital Springfield
-
Sullivan, Missouri, United States, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, United States, 63127
- Missouri Baptist Outpatient Center-Sunset Hills
-
-
Montana
-
Billings, Montana, United States, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, United States, 59101
- Saint Vincent Healthcare
-
Billings, Montana, United States, 59102
- Montana Cancer Consortium NCORP
-
Billings, Montana, United States, 59101
- Northern Rockies Radiation Oncology Center
-
Billings, Montana, United States, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, United States, 59715
- Bozeman Deaconess Hospital
-
Butte, Montana, United States, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, United States, 59405
- Great Falls Clinic
-
Great Falls, Montana, United States, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Great Falls, Montana, United States, 59405
- Berdeaux, Donald MD (UIA Investigator)
-
Havre, Montana, United States, 59501
- Northern Montana Hospital
-
Helena, Montana, United States, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, United States, 59901
- Kalispell Regional Medical Center
-
Kalispell, Montana, United States, 59901
- Glacier Oncology PLLC
-
Kalispell, Montana, United States, 59901
- Kalispell Medical Oncology
-
Missoula, Montana, United States, 59804
- Community Medical Hospital
-
Missoula, Montana, United States, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, United States, 59804
- Guardian Oncology and Center for Wellness
-
Missoula, Montana, United States, 59802
- Montana Cancer Specialists
-
-
Nebraska
-
Grand Island, Nebraska, United States, 68803
- CHI Health Saint Francis
-
Kearney, Nebraska, United States, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, United States, 68845
- Heartland Hematology and Oncology
-
Lincoln, Nebraska, United States, 68510
- Nebraska Cancer Research Center
-
Lincoln, Nebraska, United States, 68510
- Saint Elizabeth Regional Medical Center
-
North Platte, Nebraska, United States, 69101
- Great Plains Health Callahan Cancer Center
-
Omaha, Nebraska, United States, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, United States, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, United States, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, United States, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, United States, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, United States, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, United States, 68106
- Missouri Valley Cancer Consortium
-
Omaha, Nebraska, United States, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, United States, 68046
- Midlands Community Hospital
-
-
Nevada
-
Henderson, Nevada, United States, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, United States, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, United States, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, United States, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, United States, 89074
- GenesisCare USA - Henderson
-
Las Vegas, Nevada, United States, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, United States, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, United States, 89109
- GenesisCare USA - Las Vegas
-
Las Vegas, Nevada, United States, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, United States, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, United States, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, United States, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, United States, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, United States, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, United States, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, United States, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, United States, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, United States, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, United States, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, United States, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, United States, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, United States, 89128
- GenesisCare USA - Vegas Tenaya
-
Las Vegas, Nevada, United States, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, United States, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, United States, 89148
- GenesisCare USA - Fort Apache
-
Las Vegas, Nevada, United States, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, United States, 89169
- Nevada Cancer Research Foundation NCORP
-
Las Vegas, Nevada, United States, 89135
- Nevada Cancer Institute-Summerlin Campus
-
-
New Hampshire
-
Concord, New Hampshire, United States, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Laconia, New Hampshire, United States, 03246
- LRGHealthcare-Lakes Region General Hospital
-
Lebanon, New Hampshire, United States, 03756
- Dartmouth Hitchcock Medical Center
-
Londonderry, New Hampshire, United States, 03053
- The Dana-Farber Cancer Institute at Londonderry
-
Manchester, New Hampshire, United States, 03103
- Solinsky Center for Cancer Care
-
-
New Jersey
-
Basking Ridge, New Jersey, United States, 07920
- Memorial Sloan Kettering Basking Ridge
-
Camden, New Jersey, United States, 08103
- Cooper Hospital University Medical Center
-
East Orange, New Jersey, United States, 07018-1095
- Veterans Adminstration New Jersey Health Care System
-
Hackensack, New Jersey, United States, 07601
- Hackensack University Medical Center
-
Morristown, New Jersey, United States, 07960
- Morristown Medical Center
-
Mount Holly, New Jersey, United States, 08060
- Virtua Memorial
-
Newark, New Jersey, United States, 07101
- Rutgers New Jersey Medical School
-
Pennington, New Jersey, United States, 08534
- Capital Health Medical Center-Hopewell
-
Somerville, New Jersey, United States, 08876
- Robert Wood Johnson University Hospital Somerset
-
Summit, New Jersey, United States, 07902
- Overlook Hospital
-
Vineland, New Jersey, United States, 08360
- Inspira Medical Center Vineland
-
Voorhees, New Jersey, United States, 08043
- Virtua Voorhees
-
Voorhees, New Jersey, United States, 08043
- MD Anderson Cancer Center at Cooper-Voorhees
-
-
New Mexico
-
Albuquerque, New Mexico, United States, 87102
- University of New Mexico Cancer Center
-
-
New York
-
Auburn, New York, United States, 13021
- Hematology Oncology Associates of Central New York-Auburn
-
Brooklyn, New York, United States, 11209
- Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus
-
Buffalo, New York, United States, 14263
- Roswell Park Cancer Institute
-
Buffalo, New York, United States, 14215
- Veterans Affairs Western New York Health Care System-Buffalo
-
Commack, New York, United States, 11725
- Memorial Sloan Kettering Commack
-
East Syracuse, New York, United States, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Glens Falls, New York, United States, 12801
- Glens Falls Hospital
-
Middletown, New York, United States, 10940
- Garnet Health Medical Center
-
New York, New York, United States, 10065
- Memorial Sloan Kettering Cancer Center
-
New York, New York, United States, 10019
- Mount Sinai West
-
New York, New York, United States, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
New York, New York, United States, 10065
- NYP/Weill Cornell Medical Center
-
New York, New York, United States, 10016
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
-
New York, New York, United States, 10003
- Mount Sinai Union Square
-
Rochester, New York, United States, 14642
- University of Rochester
-
Rochester, New York, United States, 14623
- Interlakes Foundation Inc-Rochester
-
Sleepy Hollow, New York, United States, 10591
- Memorial Sloan Kettering Sleepy Hollow
-
Staten Island, New York, United States, 10305
- Staten Island University Hospital
-
Syracuse, New York, United States, 13210
- State University of New York Upstate Medical University
-
Syracuse, New York, United States, 13215
- Hematology Oncology Associates of Central New York-Onondaga Hill
-
Uniondale, New York, United States, 11553
- Memorial Sloan Kettering Nassau
-
-
North Carolina
-
Asheboro, North Carolina, United States, 27203
- Randolph Hospital
-
Chapel Hill, North Carolina, United States, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Charlotte, North Carolina, United States, 28203
- Carolinas Medical Center/Levine Cancer Institute
-
Charlotte, North Carolina, United States, 28204
- Novant Health Presbyterian Medical Center
-
Clinton, North Carolina, United States, 28328
- Southeastern Medical Oncology Center-Clinton
-
Concord, North Carolina, United States, 28025
- Atrium Health Cabarrus/LCI-Concord
-
Durham, North Carolina, United States, 27710
- Duke University Medical Center
-
Goldsboro, North Carolina, United States, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, United States, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, United States, 27403
- Cone Health Cancer Center
-
Greenville, North Carolina, United States, 27834
- East Carolina University
-
Hendersonville, North Carolina, United States, 28791
- Hendersonville Hematology and Oncology at Pardee
-
Hendersonville, North Carolina, United States, 28791
- Margaret R Pardee Memorial Hospital
-
Hendersonville, North Carolina, United States, 28792
- AdventHealth Hendersonville
-
High Point, North Carolina, United States, 27262
- High Point Regional Hospital
-
Jacksonville, North Carolina, United States, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kinston, North Carolina, United States, 28501
- Vidant Oncology-Kinston
-
Lumberton, North Carolina, United States, 28358
- Southeastern Regional Medical Center
-
Monroe, North Carolina, United States, 28112
- Atrium Health Union/LCI-Union
-
Oxford, North Carolina, United States, 27565
- Granville Medical Center
-
Pinehurst, North Carolina, United States, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Raleigh, North Carolina, United States, 27609
- Duke Raleigh Hospital
-
Reidsville, North Carolina, United States, 27320
- Annie Penn Memorial Hospital
-
Roxboro, North Carolina, United States, 27573
- Person Memorial Hospital
-
Rutherfordton, North Carolina, United States, 28139
- Rutherford Hospital
-
Shelby, North Carolina, United States, 28150
- Atrium Health Cleveland/LCI-Cleveland
-
Statesville, North Carolina, United States, 28677
- Iredell Memorial Hospital
-
Winston-Salem, North Carolina, United States, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, United States, 27104
- Southeast Clinical Oncology Research Consortium NCORP
-
-
North Dakota
-
Bismarck, North Dakota, United States, 58501
- Sanford Bismarck Medical Center
-
Bismarck, North Dakota, United States, 58501
- Mid Dakota Clinic
-
Bismarck, North Dakota, United States, 58501
- Saint Alexius Medical Center
-
Fargo, North Dakota, United States, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, United States, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, United States, 58122
- Sanford Clinic North-Fargo
-
-
Ohio
-
Akron, Ohio, United States, 44307
- Cleveland Clinic Akron General
-
Beachwood, Ohio, United States, 44122
- UHHS-Chagrin Highlands Medical Center
-
Beachwood, Ohio, United States, 44122
- Cleveland Clinic Cancer Center Beachwood
-
Bellefontaine, Ohio, United States, 43311
- Mary Rutan Hospital
-
Belpre, Ohio, United States, 45714
- Strecker Cancer Center-Belpre
-
Bowling Green, Ohio, United States, 43402
- Toledo Clinic Cancer Centers-Bowling Green
-
Canton, Ohio, United States, 44708
- Cleveland Clinic Mercy Hospital
-
Canton, Ohio, United States, 44710
- Aultman Health Foundation
-
Chardon, Ohio, United States, 44024
- Geauga Hospital
-
Chillicothe, Ohio, United States, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, United States, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, United States, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, United States, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, United States, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, United States, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, United States, 44106
- Case Western Reserve University
-
Cleveland, Ohio, United States, 44109
- MetroHealth Medical Center
-
Cleveland, Ohio, United States, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, United States, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Clyde, Ohio, United States, 43410
- North Coast Cancer Care-Clyde
-
Columbus, Ohio, United States, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, United States, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, United States, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, United States, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, United States, 43228
- Doctors Hospital
-
Columbus, Ohio, United States, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, United States, 43215
- Grant Medical Center
-
Columbus, Ohio, United States, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, United States, 43215
- Columbus NCI Community Oncology Research Program
-
Dayton, Ohio, United States, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, United States, 45409
- Miami Valley Hospital
-
Dayton, Ohio, United States, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, United States, 45405
- Grandview Hospital
-
Dayton, Ohio, United States, 45428
- Dayton Veterans Affairs Medical Center
-
Delaware, Ohio, United States, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, United States, 43015
- Delaware Radiation Oncology
-
Delaware, Ohio, United States, 43015
- Grady Memorial Hospital
-
Elyria, Ohio, United States, 44035
- Mercy Cancer Center-Elyria
-
Elyria, Ohio, United States, 44035
- Hematology Oncology Center Incorporated
-
Findlay, Ohio, United States, 45840
- Blanchard Valley Hospital
-
Franklin, Ohio, United States, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Greenville, Ohio, United States, 45331
- Wayne Hospital
-
Independence, Ohio, United States, 44131
- Cleveland Clinic Cancer Center Independence
-
Kettering, Ohio, United States, 45429
- Kettering Medical Center
-
Lancaster, Ohio, United States, 43130
- Fairfield Medical Center
-
Lancaster, Ohio, United States, 43130
- Lancaster Radiation Oncology
-
Lima, Ohio, United States, 45801
- Saint Rita's Medical Center
-
Lima, Ohio, United States, 45804
- Lima Memorial Hospital
-
Marietta, Ohio, United States, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, United States, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, United States, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Maumee, Ohio, United States, 43537
- Saint Luke's Hospital
-
Mayfield Heights, Ohio, United States, 44124
- Hillcrest Hospital Cancer Center
-
Mayfield Heights, Ohio, United States, 44124
- UH Seidman Cancer Center at Landerbrook Health Center
-
Mentor, Ohio, United States, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middleburg Heights, Ohio, United States, 44130
- UH Seidman Cancer Center at Southwest General Hospital
-
Mount Vernon, Ohio, United States, 43050
- Knox Community Hospital
-
Newark, Ohio, United States, 43055
- Licking Memorial Hospital
-
Newark, Ohio, United States, 43055
- Newark Radiation Oncology
-
Norwalk, Ohio, United States, 44857
- Fisher-Titus Medical Center
-
Oregon, Ohio, United States, 43616
- Saint Charles Hospital
-
Oregon, Ohio, United States, 43616
- Toledo Clinic Cancer Centers-Oregon
-
Parma, Ohio, United States, 44129
- University Hospitals Parma Medical Center
-
Portsmouth, Ohio, United States, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, United States, 44870
- North Coast Cancer Care
-
Sandusky, Ohio, United States, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Springfield, Ohio, United States, 45505
- Springfield Regional Medical Center
-
Strongsville, Ohio, United States, 44136
- Cleveland Clinic Cancer Center Strongsville
-
Sylvania, Ohio, United States, 43560
- ProMedica Flower Hospital
-
Tiffin, Ohio, United States, 44883
- Mercy Hospital of Tiffin
-
Toledo, Ohio, United States, 43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Toledo, Ohio, United States, 43608
- Saint Vincent Mercy Medical Center
-
Toledo, Ohio, United States, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, United States, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, United States, 43614
- University of Toledo
-
Toledo, Ohio, United States, 43617
- Toledo Community Hospital Oncology Program CCOP
-
Troy, Ohio, United States, 45373
- Upper Valley Medical Center
-
Wauseon, Ohio, United States, 43567
- Fulton County Health Center
-
Westerville, Ohio, United States, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, United States, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Westlake, Ohio, United States, 44145
- UHHS-Westlake Medical Center
-
Wilmington, Ohio, United States, 45177
- Clinton Memorial Hospital
-
Wooster, Ohio, United States, 44691
- Cleveland Clinic Wooster Family Health and Surgery Center
-
Xenia, Ohio, United States, 45385
- Greene Memorial Hospital
-
Zanesville, Ohio, United States, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, United States, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Norman, Oklahoma, United States, 73071
- Cancer Care Associates-Norman
-
Oklahoma City, Oklahoma, United States, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, United States, 73120
- Mercy Physicians of Oklahoma-Lakeside
-
Tulsa, Oklahoma, United States, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
Tulsa, Oklahoma, United States, 74136
- Natalie Warren Bryant Cancer Center at Saint Francis
-
Tulsa, Oklahoma, United States, 74146
- Warren Clinic Oncology-Tulsa
-
-
Oregon
-
Corvallis, Oregon, United States, 97330
- Good Samaritan Hospital
-
-
Pennsylvania
-
Abington, Pennsylvania, United States, 19001
- Jefferson Abington Hospital
-
Allentown, Pennsylvania, United States, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, United States, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Butler, Pennsylvania, United States, 16001
- Butler Memorial Hospital
-
Danville, Pennsylvania, United States, 17822
- Geisinger Medical Center
-
Doylestown, Pennsylvania, United States, 18901
- Doylestown Hospital
-
Hazleton, Pennsylvania, United States, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Lewisburg, Pennsylvania, United States, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, United States, 17044
- Lewistown Hospital
-
Philadelphia, Pennsylvania, United States, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, United States, 19114
- Jefferson Torresdale Hospital
-
Philadelphia, Pennsylvania, United States, 19107
- Pennsylvania Hospital
-
Pottstown, Pennsylvania, United States, 19464
- Pottstown Hospital
-
Pottsville, Pennsylvania, United States, 17901
- Geisinger Cancer Services-Pottsville
-
Sayre, Pennsylvania, United States, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
State College, Pennsylvania, United States, 16801
- Geisinger Medical Group
-
West Reading, Pennsylvania, United States, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, United States, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, United States, 17701
- UPMC Susquehanna
-
-
South Carolina
-
Anderson, South Carolina, United States, 29621
- AnMed Health Cancer Center
-
Anderson, South Carolina, United States, 29621
- AnMed Health Hospital
-
Boiling Springs, South Carolina, United States, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, United States, 29425
- Medical University of South Carolina
-
Charleston, South Carolina, United States, 29401
- Roper Hospital
-
Charleston, South Carolina, United States, 29406
- Lowcountry Hematology Oncology PA-North Charleston
-
Charleston, South Carolina, United States, 29414
- Lowcountry Hematology Oncology PA-West Ashley
-
Charleston, South Carolina, United States, 29403
- Charleston Oncology - Roper
-
Charleston, South Carolina, United States, 29414
- Charleston Oncology - Saint Francis
-
Easley, South Carolina, United States, 29640
- Prisma Health Cancer Institute - Easley
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, United States, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, United States, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, United States, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenville, South Carolina, United States, 29601
- Greenville Health System Cancer Institute-Andrews
-
Greenwood, South Carolina, United States, 29646
- Self Regional Healthcare
-
Greer, South Carolina, United States, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, United States, 29651
- Gibbs Cancer Center-Pelham
-
Lancaster, South Carolina, United States, 29720
- Carolina Blood and Cancer Care Associates PA-Lancaster
-
Mount Pleasant, South Carolina, United States, 29464
- Lowcountry Hematology Oncology PA-Mount Pleasant
-
Rock Hill, South Carolina, United States, 29732
- Carolina Blood and Cancer Care Associates PA
-
Seneca, South Carolina, United States, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, United States, 29303
- Spartanburg Medical Center
-
-
South Dakota
-
Sioux Falls, South Dakota, United States, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, United States, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, United States, 57104
- Sanford Cancer Center Oncology Clinic
-
Sioux Falls, South Dakota, United States, 57105
- Medical X-Ray Center
-
-
Tennessee
-
Bristol, Tennessee, United States, 37620
- Wellmont Medical Associates Oncology and Hematology-Bristol
-
Chattanooga, Tennessee, United States, 37404
- Memorial Hospital
-
Chattanooga, Tennessee, United States, 37403
- Erlanger Medical Center
-
Hixson, Tennessee, United States, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Kingsport, Tennessee, United States, 37660
- Ballad Health Cancer Care - Kingsport
-
Kingsport, Tennessee, United States, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Ooltewah, Tennessee, United States, 37363
- Memorial GYN Plus
-
-
Texas
-
Dallas, Texas, United States, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Houston, Texas, United States, 77030
- Houston Methodist Hospital
-
Houston, Texas, United States, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Houston, Texas, United States, 77030
- Michael E DeBakey VA Medical Center
-
Houston, Texas, United States, 77030
- Ben Taub General Hospital
-
Houston, Texas, United States, 77030
- Baylor Saint Luke's Medical Center
-
-
Vermont
-
Bennington, Vermont, United States, 05201
- Southwestern Vermont Medical Center
-
Berlin, Vermont, United States, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, United States, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Danville, Virginia, United States, 24541
- Danville Regional Medical Center
-
Fredericksburg, Virginia, United States, 22401
- Fredericksburg Oncology Inc
-
Fredericksburg, Virginia, United States, 22408
- Hematology Oncology Associates of Fredericksburg Inc
-
Lynchburg, Virginia, United States, 24501
- Centra Lynchburg Hematology-Oncology Clinic Inc
-
Martinsville, Virginia, United States, 24115
- Sovah Health Martinsville
-
Norton, Virginia, United States, 24273
- Southwest VA Regional Cancer Center
-
Richmond, Virginia, United States, 23298
- Virginia Commonwealth University/Massey Cancer Center
-
-
Washington
-
Anacortes, Washington, United States, 98221
- Cancer Care Center at Island Hospital
-
Auburn, Washington, United States, 98001
- MultiCare Auburn Medical Center
-
Bellevue, Washington, United States, 98004
- Overlake Medical Center
-
Bellingham, Washington, United States, 98225
- PeaceHealth Saint Joseph Medical Center
-
Bremerton, Washington, United States, 98310
- Harrison HealthPartners Hematology and Oncology-Bremerton
-
Burien, Washington, United States, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, United States, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, United States, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, United States, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, United States, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, United States, 98003
- Saint Francis Hospital
-
Issaquah, Washington, United States, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, United States, 99336
- Kadlec Clinic Hematology and Oncology
-
Kirkland, Washington, United States, 98034
- Seattle Cancer Care Alliance at EvergreenHealth
-
Kirkland, Washington, United States, 98033
- EvergreenHealth Medical Center
-
Lacey, Washington, United States, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, United States, 98499
- Saint Clare Hospital
-
Mount Vernon, Washington, United States, 98274
- Skagit Valley Hospital
-
Olympia, Washington, United States, 98506-5166
- Providence - Saint Peter Hospital
-
Olympia, Washington, United States, 98507
- Capital Medical Center
-
Poulsbo, Washington, United States, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Puyallup, Washington, United States, 98372
- MultiCare Good Samaritan Hospital
-
Seattle, Washington, United States, 98109
- Fred Hutchinson Cancer Research Center
-
Seattle, Washington, United States, 98104
- Harborview Medical Center
-
Seattle, Washington, United States, 98101
- Virginia Mason Medical Center
-
Seattle, Washington, United States, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, United States, 98195
- University of Washington Medical Center - Montlake
-
Seattle, Washington, United States, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, United States, 98104
- Minor and James Medical PLLC
-
Seattle, Washington, United States, 98122-4307
- Swedish Medical Center-First Hill
-
Seattle, Washington, United States, 98104
- Pacific Medical Center-First Hill
-
Sedro-Woolley, Washington, United States, 98284
- PeaceHealth United General Medical Center
-
Spokane, Washington, United States, 99218
- Evergreen Hematology and Oncology PS
-
Spokane, Washington, United States, 99202
- Cancer Care Northwest - Spokane South
-
Spokane, Washington, United States, 99220
- Rockwood Clinic
-
Tacoma, Washington, United States, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, United States, 98431
- Madigan Army Medical Center
-
Tacoma, Washington, United States, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, United States, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Tacoma, Washington, United States, 98405
- MultiCare Allenmore Hospital
-
Tacoma, Washington, United States, 98405
- Northwest NCI Community Oncology Research Program
-
Tacoma, Washington, United States, 98405
- Saint Joseph Medical Center
-
Wenatchee, Washington, United States, 98801
- Wenatchee Valley Hospital and Clinics
-
-
West Virginia
-
Charleston, West Virginia, United States, 25304
- West Virginia University Charleston Division
-
Huntington, West Virginia, United States, 25701
- Edwards Comprehensive Cancer Center
-
Morgantown, West Virginia, United States, 26506
- West Virginia University Healthcare
-
-
Wisconsin
-
Antigo, Wisconsin, United States, 54409
- Langlade Hospital and Cancer Center
-
Burlington, Wisconsin, United States, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, United States, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, United States, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Germantown, Wisconsin, United States, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, United States, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, United States, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, United States, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, United States, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, United States, 54303
- Green Bay Oncology Limited at Saint Mary's Hospital
-
Green Bay, Wisconsin, United States, 54301-3526
- Green Bay Oncology at Saint Vincent Hospital
-
Johnson Creek, Wisconsin, United States, 53038
- UW Cancer Center Johnson Creek
-
Kenosha, Wisconsin, United States, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, United States, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, United States, 53792
- University of Wisconsin Carbone Cancer Center
-
Manitowoc, Wisconsin, United States, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, United States, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, United States, 54143
- Bay Area Medical Center
-
Marshfield, Wisconsin, United States, 54449
- Marshfield Medical Center-Marshfield
-
Milwaukee, Wisconsin, United States, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, United States, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, United States, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, United States, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, United States, 54548
- Marshfield Clinic-Minocqua Center
-
New Richmond, Wisconsin, United States, 54017
- Cancer Center of Western Wisconsin
-
Oconto Falls, Wisconsin, United States, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, United States, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, United States, 53406
- Aurora Cancer Care-Racine
-
Rhinelander, Wisconsin, United States, 54501
- Ascension Saint Mary's Hospital
-
Rice Lake, Wisconsin, United States, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, United States, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, United States, 53081
- HSHS Saint Nicholas Hospital
-
Stevens Point, Wisconsin, United States, 54481
- Ascension Saint Michael's Hospital
-
Sturgeon Bay, Wisconsin, United States, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Sturgeon Bay, Wisconsin, United States, 54235
- Green Bay Oncology - Sturgeon Bay
-
Summit, Wisconsin, United States, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, United States, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, United States, 53188
- Aurora Cancer Care-Waukesha
-
Wausau, Wisconsin, United States, 54401
- Aspirus Regional Cancer Center
-
Wausau, Wisconsin, United States, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, United States, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, United States, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, United States, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, United States, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Casper, Wyoming, United States, 82609
- Rocky Mountain Oncology
-
Cheyenne, Wyoming, United States, 82001
- Cheyenne Regional Medical Center-West
-
Sheridan, Wyoming, United States, 82801
- Welch Cancer Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
16 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
Patients must have histologically or cytologically documented metastatic or unresectable transitional cell (urothelial) carcinoma of the urinary tract (renal pelvis, ureter, bladder, prostate, or urethra), with metastatic or locally advanced disease (T4b, N2, N3, or M1); patients must not be candidates for potentially curative surgery or radiotherapy
- For patients that have had surgical resection prior to study enrollment, residual or unresected disease (measurable and/or unmeasurable) must be evident on post-surgical scans
Prior treatment for transitional cell carcinoma (TCC)
- Patients may not have received combination systemic chemotherapy for metastatic disease
- For the purposes of this study, radiosensitizing single agent chemotherapy is not considered prior systemic therapy
- Prior neoadjuvant or adjuvant systemic chemotherapy is permissible provided the interval from end of therapy to diagnosis of metastatic disease is at least 1 year
- >= 4 weeks since any prior radiation (including palliative) or major surgery and fully recovered
- >= 7 days since any minor surgery such as port placement
- >= 4 weeks since any intravesical therapy
- No prior treatment with bevacizumab or other angiogenesis inhibitors
- No known history of brain metastases; brain imaging (magnetic resonance imaging [MRI]/computed tomography [CT]) is not required
- No current congestive heart failure; New York Heart Association (NYHA) class II, III or IV
- Patients with history of hypertension must be well controlled (< 150/90) on a regimen of anti-hypertensive therapy
- Patients on full-dose anticoagulants must be on a stable dose of warfarin and have an in-range international normalized ratio (INR) (usually between 2 and 3) or be on a stable dose of low molecular weight (LMW) heparin; patients receiving anti-platelet agents are also eligible; in addition, patients who are on daily prophylactic aspirin or anticoagulation for atrial fibrillation are eligible
No significant history of bleeding events or gastrointestinal (GI) perforation
- Patients with a history of a significant bleeding episode (e.g. hemoptysis, upper or lower GI bleeding, grade 3 or 4 gross hematuria unable to be controlled by trans-urethral resection of the bladder tumor) within 6 months of registration are not eligible
- Patients with a history of GI perforation within 12 months of registration are not eligible
- Patients with a history of peritoneal carcinomatosis are not eligible
- No arterial thrombotic events within 6 months of registration, including transient ischemic attack (TIA), cerebrovascular accident (CVA), peripheral arterial thrombus, unstable angina or angina requiring surgical or medical intervention in the past 6 months, or myocardial infarction (MI); patients with clinically significant peripheral artery disease (i.e., claudication on less than one block) are ineligible
- Patients who have experienced a deep venous thrombosis or pulmonary embolus within the past 6 months must be on stable therapeutic anticoagulation to be enrolled to this study
- No serious or non-healing wound, ulcer, or bone fracture
- No sensory or motor peripheral neuropathy >= grade 2
- Patients with known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies are not eligible
Patients that are pregnant or nursing are not eligible; women of child bearing potential must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of human chorionic gonadotropin [HCG]) within 72 hours prior to registration
- For women of child-bearing potential with an elevated beta-HCG that is believed to be related to cancer and not pregnancy, a negative trans-vaginal ultrasound and gynecological examination are required
- Women of child-bearing potential include any female who has experienced menarche and who has not undergone surgical sterilization (hysterectomy, bilateral tubal ligation or bilateral oophorectomy) or is not postmenopausal [defined as amenorrhea >= 12 consecutive months; or women on hormone replacement therapy [HRT] with documented serum follicle stimulating hormone [FSH] level > 35 mIU/mL); even women who are using oral, implanted or injectable contraceptive hormones or mechanical products such as an intrauterine device or barrier methods (diaphragm, condoms, spermicides) to prevent pregnancy or practicing abstinence or where partner is sterile (e.g., vasectomy), should be considered to be of child bearing potential
- Eastern Cooperative Oncology Group (ECOG) performance status 0-1 (or Karnofsky performance status [KPS] >= 80)
- Absolute neutrophil count (ANC) >= 1,500/uL
- Platelet count >= 100,000/uL
- Calculated or measured creatinine clearance >= 50 mL/minute
- Bilirubin =< 1.25 times upper limits of normal; for patients with Gilbert's disease, =< 2.5 x upper limit of normal (ULN) is allowed
- Aspartate aminotransferase (AST) =< 2.0 x upper limits of normal
- Urine protein to creatinine ratio < 1.0 or urine protein =< 1+ or 24-hour urine protein =< 1 gram
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Active Comparator: Arm I (gemcitabine hydrochloride, cisplatin, placebo)
Patients receive gemcitabine hydrochloride IV over 30 minutes on days 1 and 8 and cisplatin IV and placebo IV over 30-90 minutes on day 1.
Treatment repeats every 21 days for 6 cycles in the absence of disease progression or unacceptable toxicity.
Patients then receive placebo IV over 30-90 minutes every 21 days in the absence of disease progression or unacceptable toxicity.
|
Correlative studies
Given IV
Other Names:
Given IV
Other Names:
Given IV
|
|
Experimental: Arm II (gemcitabine hydrochloride, cisplatin, bevacizumab)
Patients receive gemcitabine hydrochloride and cisplatin as in arm I. Patients also receive bevacizumab IV over 30-90 minutes on day 1.
Treatment repeats every 21 days for 6 cycles in the absence of disease progression or unacceptable toxicity.
Patients then receive bevacizumab IV over 30-90 minutes every 21 days in the absence of disease progression or unacceptable toxicity.
|
Correlative studies
Given IV
Other Names:
Given IV
Other Names:
Given IV
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Overall Survival (OS)
Time Frame: From date of randomization to date of death due to any cause, assessed up to 7 years
|
Overall survival time is defined as the time from randomization to death due to any cause.
The median and 95% confidence intervals are estimated using the Kaplan-Meier estimator.The stratified log-rank statistic will be the primary analysis to compare the two treatment arms on OS with the stratification factors: presence of visceral metastases (no, yes) and prior chemotherapy (no, yes).
In addition, the proportional hazards model will be used to assess the importance of the treatment arm adjusting on patient characteristics, stratification variables and other important covariates in predicting OS.
|
From date of randomization to date of death due to any cause, assessed up to 7 years
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Progression-free Survival (PFS)
Time Frame: From the date of randomization to date of progression or death due to any cause, whichever occurs first, assessed up to 7 years
|
The primary analysis of PFS will be a two-sided stratified log-rank test comparing arm A and arm B. The stratification factors will consist of the two stratification factors used for patient randomization: prior nephrectomy (yes vs. no) and Motzer score (0 vs. 1-2 vs. 3+).
Results from unstratified log-rank tests will also be provided.
Kaplan-Meier methodology will be used to estimate median PFS for each treatment arm.
|
From the date of randomization to date of progression or death due to any cause, whichever occurs first, assessed up to 7 years
|
|
Objective Response
Time Frame: Up to 7 years
|
Objective response is defined as confirmed complete and partial responses using Response Evaluation Criteria in Solid Tumors criteria. A complete response (CR) is defined as a disappearance of all target lesions. A partial response (PR) is defined as having at least a 30% decrease in the sum of the longest diameter of target lesions taking as reference the baseline sum. In each arm, the number of patients reporting a CR or PR was divided by the number of patients evaluable in each arm to obtain the proportion. |
Up to 7 years
|
|
Number of Patients Experiencing Grade 3+ Toxicity
Time Frame: Up to 7 years
|
The number of patients experiencing grade 3 or higher toxicity (adverse events considered at least possibly related to treatment) is reported below.
|
Up to 7 years
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Jonathan E Rosenberg, Alliance for Clinical Trials in Oncology
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
July 15, 2009
Primary Completion (Actual)
November 2, 2018
Study Completion (Actual)
June 15, 2021
Study Registration Dates
First Submitted
July 17, 2009
First Submitted That Met QC Criteria
July 17, 2009
First Posted (Estimated)
July 20, 2009
Study Record Updates
Last Update Posted (Actual)
October 16, 2023
Last Update Submitted That Met QC Criteria
October 12, 2023
Last Verified
October 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Neoplasms by Histologic Type
- Neoplasms
- Urologic Neoplasms
- Urogenital Neoplasms
- Neoplasms by Site
- Urologic Diseases
- Neoplasms, Glandular and Epithelial
- Ureteral Diseases
- Urethral Diseases
- Female Urogenital Diseases
- Female Urogenital Diseases and Pregnancy Complications
- Urogenital Diseases
- Male Urogenital Diseases
- Carcinoma
- Pelvic Neoplasms
- Carcinoma, Transitional Cell
- Ureteral Neoplasms
- Urethral Neoplasms
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Antimetabolites, Antineoplastic
- Antimetabolites
- Antineoplastic Agents
- Immunologic Factors
- Angiogenesis Inhibitors
- Angiogenesis Modulating Agents
- Growth Substances
- Growth Inhibitors
- Antibodies
- Cisplatin
- Immunoglobulins
- Bevacizumab
- Antibodies, Monoclonal
- Antineoplastic Agents, Immunological
- Immunoglobulin G
- Endothelial Growth Factors
- Gemcitabine
Other Study ID Numbers
- NCI-2011-01952 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- U10CA180821 (U.S. NIH Grant/Contract)
- U10CA031946 (U.S. NIH Grant/Contract)
- CDR0000649174
- CALGB-90601 (Other Identifier: CTEP)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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