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Gemcitabinhydroklorid og cisplatin med eller uten bevacizumab ved behandling av pasienter med avansert urinveiskreft

12. oktober 2023 oppdatert av: National Cancer Institute (NCI)

En randomisert dobbeltblindet fase III-studie som sammenligner gemcitabin, cisplatin og bevacizumab med gemcitabin, cisplatin og placebo hos pasienter med avansert overgangscellekarsinom

Denne randomiserte fase III-studien studerer gemcitabinhydroklorid, cisplatin og bevacizumab for å se hvor godt de virker sammenlignet med gemcitabinhydroklorid og cisplatin ved behandling av pasienter med urinveiskreft som har spredt seg til andre steder i kroppen. Legemidler som brukes i kjemoterapi, som gemcitabinhydroklorid og cisplatin, virker på forskjellige måter for å stoppe veksten av tumorceller, enten ved å drepe cellene, ved å stoppe dem fra å dele seg eller ved å hindre dem i å spre seg. Immunterapi med bevacizumab kan indusere endringer i kroppens immunsystem og kan forstyrre tumorcellenes evne til å vokse og spre seg. Det er ennå ikke kjent om gemcitabinhydroklorid og cisplatin er mer effektive når de gis med eller uten bevacizumab ved behandling av pasienter med urinveiskreft.

Studieoversikt

Detaljert beskrivelse

PRIMÆRE MÅL:

I. For å bestemme om pasienter med avansert overgangscellekarsinom behandlet med bevacizumab, gemcitabinhydroklorid (gemcitabin) og cisplatin vil ha økt total overlevelse sammenlignet med pasienter behandlet med gemcitabin, cisplatin og placebo.

SEKUNDÆRE MÅL:

I. Å sammenligne den progresjonsfrie overlevelsen til disse to regimene hos pasienter med avansert overgangscellekarsinom.

II. For å sammenligne andelen pasienter som opplever en objektiv respons på hvert regime.

III. For å sammenligne grad 3 og høyere toksisitet hos pasienter behandlet på de to regimene.

OVERSIGT: Pasienter randomiseres til 1 av 2 armer.

ARM I: Pasienter får gemcitabinhydroklorid intravenøst ​​(IV) over 30 minutter på dag 1 og 8, cisplatin IV og placebo IV over 30-90 minutter på dag 1. Behandlingen gjentas hver 21. dag i 6 sykluser i fravær av sykdomsprogresjon eller uakseptabel toksisitet. Pasienter får deretter placebo IV over 30-90 minutter hver 21. dag i fravær av sykdomsprogresjon eller uakseptabel toksisitet.

ARM II: Pasienter får gemcitabinhydroklorid og cisplatin som i arm I. Pasienter får også bevacizumab IV over 30-90 minutter på dag 1. Behandlingen gjentas hver 21. dag i 6 sykluser i fravær av sykdomsprogresjon eller uakseptabel toksisitet. Pasienter får deretter bevacizumab IV over 30-90 minutter hver 21. dag i fravær av sykdomsprogresjon eller uakseptabel toksisitet.

Etter avsluttet studiebehandling følges pasientene opp periodisk i inntil 7 år.

Studietype

Intervensjonell

Registrering (Faktiske)

506

Fase

  • Fase 3

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

    • Alabama
      • Birmingham, Alabama, Forente stater, 35233
        • University of Alabama at Birmingham Cancer Center
      • Mobile, Alabama, Forente stater, 36608
        • Providence Hospital
    • Alaska
      • Fairbanks, Alaska, Forente stater, 99701
        • Fairbanks Memorial Hospital
    • Arizona
      • Tucson, Arizona, Forente stater, 85704
        • University of Arizona Cancer Center-Orange Grove Campus
      • Tucson, Arizona, Forente stater, 85719
        • Banner University Medical Center - Tucson
      • Tucson, Arizona, Forente stater, 85719
        • University of Arizona Cancer Center-North Campus
    • Arkansas
      • Jonesboro, Arkansas, Forente stater, 72401
        • Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
      • Little Rock, Arkansas, Forente stater, 72205
        • University of Arkansas for Medical Sciences
      • Little Rock, Arkansas, Forente stater, 72205
        • John L McClellan Memorial Veterans Hospital
    • California
      • Berkeley, California, Forente stater, 94704
        • Alta Bates Summit Medical Center-Herrick Campus
      • Burlingame, California, Forente stater, 94010
        • Mills-Peninsula Medical Center
      • Castro Valley, California, Forente stater, 94546
        • East Bay Radiation Oncology Center
      • Castro Valley, California, Forente stater, 94546
        • Valley Medical Oncology Consultants-Castro Valley
      • Clovis, California, Forente stater, 93611
        • Community Cancer Institute
      • Concord, California, Forente stater, 94520
        • John Muir Medical Center-Concord Campus
      • Emeryville, California, Forente stater, 94608
        • Bay Area Breast Surgeons Inc
      • Emeryville, California, Forente stater, 94608
        • Epic Care Partners in Cancer Care
      • Fremont, California, Forente stater, 94538
        • Valley Medical Oncology Consultants-Fremont
      • Greenbrae, California, Forente stater, 94904
        • Marin Cancer Care Inc
      • Greenbrae, California, Forente stater, 94904
        • Marin General Hospital
      • La Jolla, California, Forente stater, 92093
        • UC San Diego Moores Cancer Center
      • Los Angeles, California, Forente stater, 90033
        • USC / Norris Comprehensive Cancer Center
      • Los Angeles, California, Forente stater, 90033
        • Los Angeles County-USC Medical Center
      • Martinez, California, Forente stater, 94553-3156
        • Contra Costa Regional Medical Center
      • Modesto, California, Forente stater, 95355
        • Memorial Medical Center
      • Mountain View, California, Forente stater, 94040
        • El Camino Hospital
      • Mountain View, California, Forente stater, 94040
        • Palo Alto Medical Foundation-Camino Division
      • Northridge, California, Forente stater, 91325
        • Northridge Hospital Medical Center
      • Novato, California, Forente stater, 94945
        • Sutter Cancer Research Consortium
      • Oakland, California, Forente stater, 94609
        • Alta Bates Summit Medical Center - Summit Campus
      • Oakland, California, Forente stater, 94609
        • Hematology and Oncology Associates-Oakland
      • Oakland, California, Forente stater, 94602
        • Highland General Hospital
      • Oakland, California, Forente stater, 94609
        • Tom K Lee Inc
      • Oakland, California, Forente stater, 94609
        • Bay Area Tumor Institute
      • Orange, California, Forente stater, 92868
        • UC Irvine Health/Chao Family Comprehensive Cancer Center
      • Orange, California, Forente stater, 92868
        • Saint Joseph Hospital - Orange
      • Palo Alto, California, Forente stater, 94304
        • Stanford Cancer Institute Palo Alto
      • Palo Alto, California, Forente stater, 94301
        • Palo Alto Medical Foundation Health Care
      • Pasadena, California, Forente stater, 91105
        • Keck Medical Center of USC Pasadena
      • Pleasanton, California, Forente stater, 94588
        • Valley Care Health System - Pleasanton
      • Pleasanton, California, Forente stater, 94588
        • Valley Medical Oncology Consultants
      • Saint Helena, California, Forente stater, 94574
        • Saint Helena Hospital
      • Salinas, California, Forente stater, 93901
        • Salinas Valley Memorial
      • San Francisco, California, Forente stater, 94115
        • California Pacific Medical Center-Pacific Campus
      • San Francisco, California, Forente stater, 94115
        • UCSF Medical Center-Mount Zion
      • San Pablo, California, Forente stater, 94806
        • Doctors Medical Center- JC Robinson Regional Cancer Center
      • Santa Cruz, California, Forente stater, 95065
        • Palo Alto Medical Foundation-Santa Cruz
      • Santa Rosa, California, Forente stater, 95403
        • Sutter Pacific Medical Foundation
      • Sunnyvale, California, Forente stater, 94086
        • Palo Alto Medical Foundation-Sunnyvale
      • Vallejo, California, Forente stater, 94589
        • Sutter Solano Medical Center/Cancer Center
      • Walnut Creek, California, Forente stater, 94598
        • John Muir Medical Center-Walnut Creek
    • Colorado
      • Alamosa, Colorado, Forente stater, 81101
        • San Luis Valley Regional Medical Center
      • Aurora, Colorado, Forente stater, 80045
        • University of Colorado Hospital
      • Aurora, Colorado, Forente stater, 80012
        • Rocky Mountain Cancer Centers-Aurora
      • Aurora, Colorado, Forente stater, 80012
        • The Medical Center of Aurora
      • Aurora, Colorado, Forente stater, 80045
        • Rocky Mountain Regional VA Medical Center
      • Boulder, Colorado, Forente stater, 80301
        • Boulder Community Hospital
      • Boulder, Colorado, Forente stater, 80304
        • Rocky Mountain Cancer Centers-Boulder
      • Colorado Springs, Colorado, Forente stater, 80907
        • Penrose-Saint Francis Healthcare
      • Colorado Springs, Colorado, Forente stater, 80907
        • Rocky Mountain Cancer Centers-Penrose
      • Denver, Colorado, Forente stater, 80210
        • Porter Adventist Hospital
      • Denver, Colorado, Forente stater, 80217-3364
        • University of Colorado
      • Denver, Colorado, Forente stater, 80205
        • Kaiser Permanente-Franklin
      • Denver, Colorado, Forente stater, 80218
        • Presbyterian - Saint Lukes Medical Center - Health One
      • Denver, Colorado, Forente stater, 80218
        • SCL Health Saint Joseph Hospital
      • Denver, Colorado, Forente stater, 80220
        • Rose Medical Center
      • Denver, Colorado, Forente stater, 80218
        • Rocky Mountain Cancer Centers-Midtown
      • Denver, Colorado, Forente stater, 80220
        • Rocky Mountain Cancer Centers-Rose
      • Denver, Colorado, Forente stater, 80218
        • Colorado Blood Cancer Institute
      • Denver, Colorado, Forente stater, 80222
        • Western States Cancer Research NCORP
      • Durango, Colorado, Forente stater, 81301
        • Mercy Medical Center
      • Durango, Colorado, Forente stater, 81301
        • Southwest Oncology PC
      • Edwards, Colorado, Forente stater, 81632
        • Shaw Cancer Center
      • Englewood, Colorado, Forente stater, 80113
        • Mountain Blue Cancer Care Center - Swedish
      • Englewood, Colorado, Forente stater, 80113
        • Swedish Medical Center
      • Fort Collins, Colorado, Forente stater, 80524
        • Poudre Valley Hospital
      • Glenwood Springs, Colorado, Forente stater, 81601
        • Valley View Hospital Cancer Center
      • Golden, Colorado, Forente stater, 80401
        • Mountain Blue Cancer Care Center
      • Grand Junction, Colorado, Forente stater, 81501
        • Saint Mary's Hospital and Regional Medical Center
      • Greeley, Colorado, Forente stater, 80631
        • North Colorado Medical Center
      • Greenwood Village, Colorado, Forente stater, 80111
        • Rocky Mountain Cancer Centers-Greenwood Village
      • Lafayette, Colorado, Forente stater, 80026
        • Kaiser Permanente-Rock Creek
      • Lakewood, Colorado, Forente stater, 80228
        • Saint Anthony Hospital
      • Lakewood, Colorado, Forente stater, 80228
        • Rocky Mountain Cancer Centers-Lakewood
      • Littleton, Colorado, Forente stater, 80120
        • Rocky Mountain Cancer Centers-Littleton
      • Littleton, Colorado, Forente stater, 80122
        • Littleton Adventist Hospital
      • Lone Tree, Colorado, Forente stater, 80124
        • Kaiser Permanente-Lone Tree
      • Lone Tree, Colorado, Forente stater, 80124
        • Sky Ridge Medical Center
      • Lone Tree, Colorado, Forente stater, 80124
        • Rocky Mountain Cancer Centers-Sky Ridge
      • Longmont, Colorado, Forente stater, 80501
        • Longmont United Hospital
      • Longmont, Colorado, Forente stater, 80501
        • Rocky Mountain Cancer Centers-Longmont
      • Loveland, Colorado, Forente stater, 80539
        • McKee Medical Center
      • Montrose, Colorado, Forente stater, 81401
        • Montrose Memorial Hospital
      • Parker, Colorado, Forente stater, 80138
        • Parker Adventist Hospital
      • Parker, Colorado, Forente stater, 80138
        • Rocky Mountain Cancer Centers-Parker
      • Pueblo, Colorado, Forente stater, 81004
        • Saint Mary Corwin Medical Center
      • Pueblo, Colorado, Forente stater, 81008
        • Rocky Mountain Cancer Centers - Pueblo
      • Thornton, Colorado, Forente stater, 80260
        • Rocky Mountain Cancer Centers-Thornton
      • Thornton, Colorado, Forente stater, 80229
        • North Suburban Medical Center
      • Wheat Ridge, Colorado, Forente stater, 80033
        • SCL Health Lutheran Medical Center
    • Connecticut
      • Danbury, Connecticut, Forente stater, 06810
        • Danbury Hospital
      • Farmington, Connecticut, Forente stater, 06030
        • University of Connecticut
      • Greenwich, Connecticut, Forente stater, 06830
        • Greenwich Hospital
      • Hartford, Connecticut, Forente stater, 06105
        • Smilow Cancer Hospital Care Center at Saint Francis
      • Hartford, Connecticut, Forente stater, 06102
        • Hartford Hospital
      • Manchester, Connecticut, Forente stater, 06040
        • Manchester Memorial Hospital
      • Meriden, Connecticut, Forente stater, 06451
        • Midstate Medical Center
      • New Haven, Connecticut, Forente stater, 06520
        • Yale University
      • Norwalk, Connecticut, Forente stater, 06856
        • Norwalk Hospital
      • Norwich, Connecticut, Forente stater, 06360
        • Eastern Connecticut Hematology and Oncology Associates
      • Stamford, Connecticut, Forente stater, 06904
        • Stamford Hospital/Bennett Cancer Center
    • Delaware
      • Lewes, Delaware, Forente stater, 19958
        • Beebe Medical Center
      • Newark, Delaware, Forente stater, 19713
        • Helen F Graham Cancer Center
      • Newark, Delaware, Forente stater, 19713
        • Delaware Clinical and Laboratory Physicians PA
      • Newark, Delaware, Forente stater, 19713
        • Medical Oncology Hematology Consultants PA
      • Newark, Delaware, Forente stater, 19718
        • Christiana Care Health System-Christiana Hospital
      • Newark, Delaware, Forente stater, 19713
        • Christiana Gynecologic Oncology LLC
      • Rehoboth Beach, Delaware, Forente stater, 19971
        • Beebe Health Campus
      • Seaford, Delaware, Forente stater, 19973
        • TidalHealth Nanticoke / Allen Cancer Center
      • Wilmington, Delaware, Forente stater, 19801
        • Christiana Care Health System-Wilmington Hospital
    • District of Columbia
      • Washington, District of Columbia, Forente stater, 20010
        • MedStar Washington Hospital Center
      • Washington, District of Columbia, Forente stater, 20007
        • MedStar Georgetown University Hospital
      • Washington, District of Columbia, Forente stater, 20016
        • Sibley Memorial Hospital
    • Florida
      • Altamonte Springs, Florida, Forente stater, 32701
        • AdventHealth Altamonte
      • Fort Lauderdale, Florida, Forente stater, 33308
        • Holy Cross Hospital
      • Jupiter, Florida, Forente stater, 33458
        • Jupiter Medical Center
      • Kissimmee, Florida, Forente stater, 34744
        • AdventHealth Kissimmee
      • Miami Beach, Florida, Forente stater, 33140
        • Mount Sinai Medical Center
      • Orlando, Florida, Forente stater, 32806
        • Orlando Health Cancer Institute
      • Orlando, Florida, Forente stater, 32803
        • AdventHealth Orlando
      • Orlando, Florida, Forente stater, 32803
        • AdventHealth Medical Group Urology at Orlando
      • Orlando, Florida, Forente stater, 32822
        • AdventHealth East Orlando
      • Weston, Florida, Forente stater, 33331
        • Cleveland Clinic-Weston
      • Winter Park, Florida, Forente stater, 32792
        • AdventHealth Winter Park
    • Georgia
      • Atlanta, Georgia, Forente stater, 30342
        • Emory Saint Joseph's Hospital
      • Atlanta, Georgia, Forente stater, 30309
        • Piedmont Hospital
      • Atlanta, Georgia, Forente stater, 30342
        • Northside Hospital
      • Atlanta, Georgia, Forente stater, 30342
        • Atlanta Regional CCOP
      • Austell, Georgia, Forente stater, 30106
        • WellStar Cobb Hospital
      • Columbus, Georgia, Forente stater, 31904
        • John B Amos Cancer Center
      • Decatur, Georgia, Forente stater, 30033
        • Dekalb Medical Center
      • Fayetteville, Georgia, Forente stater, 30214
        • Piedmont Fayette Hospital
      • Gainesville, Georgia, Forente stater, 30501
        • Northeast Georgia Medical Center-Gainesville
      • Lawrenceville, Georgia, Forente stater, 30046
        • Northside Hospital - Gwinnett
      • Macon, Georgia, Forente stater, 31201
        • Medical Center of Central Georgia
      • Marietta, Georgia, Forente stater, 30060
        • WellStar Kennestone Hospital
      • Riverdale, Georgia, Forente stater, 30274
        • Southern Regional Medical Center
      • Rome, Georgia, Forente stater, 30165
        • Harbin Clinic Medical Oncology and Clinical Research
      • Savannah, Georgia, Forente stater, 31405
        • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
      • Savannah, Georgia, Forente stater, 31404
        • Memorial Health University Medical Center
    • Hawaii
      • 'Aiea, Hawaii, Forente stater, 96701
        • Pali Momi Medical Center
      • 'Aiea, Hawaii, Forente stater, 96701
        • Queen's Cancer Center - Pearlridge
      • Honolulu, Hawaii, Forente stater, 96813
        • Queen's Medical Center
      • Honolulu, Hawaii, Forente stater, 96813
        • Hawaii Cancer Care Inc - Waterfront Plaza
      • Honolulu, Hawaii, Forente stater, 96813
        • Straub Clinic and Hospital
      • Honolulu, Hawaii, Forente stater, 96813
        • University of Hawaii Cancer Center
      • Honolulu, Hawaii, Forente stater, 96817
        • Kuakini Medical Center
      • Honolulu, Hawaii, Forente stater, 96817
        • Queen's Cancer Center - Kuakini
      • Honolulu, Hawaii, Forente stater, 96826
        • Kapiolani Medical Center for Women and Children
      • Kailua, Hawaii, Forente stater, 96734
        • Castle Medical Center
      • Lihue, Hawaii, Forente stater, 96766
        • Wilcox Memorial Hospital and Kauai Medical Clinic
    • Idaho
      • Boise, Idaho, Forente stater, 83706
        • Saint Alphonsus Cancer Care Center-Boise
      • Boise, Idaho, Forente stater, 83712
        • Saint Luke's Cancer Institute - Boise
      • Fruitland, Idaho, Forente stater, 83619
        • Saint Luke's Cancer Institute - Fruitland
      • Lewiston, Idaho, Forente stater, 83501
        • Saint Joseph Regional Medical Center
      • Meridian, Idaho, Forente stater, 83642
        • Idaho Urologic Institute-Meridian
      • Meridian, Idaho, Forente stater, 83642
        • Saint Luke's Cancer Institute - Meridian
      • Nampa, Idaho, Forente stater, 83686
        • Saint Luke's Cancer Institute - Nampa
      • Post Falls, Idaho, Forente stater, 83854
        • Kootenai Clinic Cancer Services - Post Falls
      • Twin Falls, Idaho, Forente stater, 83301
        • Saint Luke's Cancer Institute - Twin Falls
    • Illinois
      • Alton, Illinois, Forente stater, 62002
        • Saint Anthony's Health
      • Aurora, Illinois, Forente stater, 60504
        • Rush - Copley Medical Center
      • Bloomington, Illinois, Forente stater, 61704
        • Illinois CancerCare-Bloomington
      • Bloomington, Illinois, Forente stater, 61701
        • Saint Joseph Medical Center
      • Canton, Illinois, Forente stater, 61520
        • Illinois CancerCare-Canton
      • Canton, Illinois, Forente stater, 61520
        • Graham Hospital Association
      • Carbondale, Illinois, Forente stater, 62902
        • Memorial Hospital of Carbondale
      • Carthage, Illinois, Forente stater, 62321
        • Illinois CancerCare-Carthage
      • Carthage, Illinois, Forente stater, 62321
        • Memorial Hospital
      • Centralia, Illinois, Forente stater, 62801
        • Centralia Oncology Clinic
      • Chicago, Illinois, Forente stater, 60611
        • Northwestern University
      • Chicago, Illinois, Forente stater, 60637
        • University of Chicago Comprehensive Cancer Center
      • Chicago, Illinois, Forente stater, 60611
        • Hematology and Oncology Associates
      • Danville, Illinois, Forente stater, 61832
        • Carle on Vermilion
      • Decatur, Illinois, Forente stater, 62526
        • Decatur Memorial Hospital
      • Decatur, Illinois, Forente stater, 62526
        • Cancer Care Specialists of Illinois - Decatur
      • Decatur, Illinois, Forente stater, 62526
        • Heartland Cancer Research NCORP
      • Effingham, Illinois, Forente stater, 62401
        • Crossroads Cancer Center
      • Effingham, Illinois, Forente stater, 62401
        • Carle Physician Group-Effingham
      • Elmhurst, Illinois, Forente stater, 60126
        • Elmhurst Memorial Hospital
      • Eureka, Illinois, Forente stater, 61530
        • Illinois CancerCare-Eureka
      • Eureka, Illinois, Forente stater, 61530
        • Eureka Hospital
      • Galesburg, Illinois, Forente stater, 61401
        • Western Illinois Cancer Treatment Center
      • Galesburg, Illinois, Forente stater, 61401
        • Illinois CancerCare-Galesburg
      • Geneva, Illinois, Forente stater, 60134
        • Northwestern Medicine Cancer Center Delnor
      • Havana, Illinois, Forente stater, 62644
        • Mason District Hospital
      • Havana, Illinois, Forente stater, 62644
        • Illinois CancerCare-Havana
      • Highland Park, Illinois, Forente stater, 60035
        • Hematology Oncology Associates of Illinois-Highland Park
      • Hines, Illinois, Forente stater, 60141
        • Edward Hines Jr VA Hospital
      • Joliet, Illinois, Forente stater, 60432
        • Midwest Center for Hematology Oncology
      • Kankakee, Illinois, Forente stater, 60901
        • Presence Saint Mary's Hospital
      • Kewanee, Illinois, Forente stater, 61443
        • Illinois CancerCare-Kewanee Clinic
      • La Grange, Illinois, Forente stater, 60525
        • AMITA Health Adventist Medical Center
      • Libertyville, Illinois, Forente stater, 60048
        • AMG Libertyville - Oncology
      • Macomb, Illinois, Forente stater, 61455
        • Illinois CancerCare-Macomb
      • Macomb, Illinois, Forente stater, 61455
        • Mcdonough District Hospital
      • Mattoon, Illinois, Forente stater, 61938
        • Carle Physician Group-Mattoon/Charleston
      • Maywood, Illinois, Forente stater, 60153
        • Loyola University Medical Center
      • Monmouth, Illinois, Forente stater, 61462
        • Illinois CancerCare-Monmouth
      • Monmouth, Illinois, Forente stater, 61462
        • Holy Family Medical Center
      • Mount Vernon, Illinois, Forente stater, 62864
        • Good Samaritan Regional Health Center
      • New Lenox, Illinois, Forente stater, 60451
        • UC Comprehensive Cancer Center at Silver Cross
      • Niles, Illinois, Forente stater, 60714
        • Illinois Cancer Specialists-Niles
      • Normal, Illinois, Forente stater, 61761
        • Carle Cancer Institute Normal
      • Normal, Illinois, Forente stater, 61761
        • Bromenn Regional Medical Center
      • Normal, Illinois, Forente stater, 61761
        • Illinois CancerCare-Community Cancer Center
      • Ottawa, Illinois, Forente stater, 61350
        • Illinois CancerCare-Ottawa Clinic
      • Ottawa, Illinois, Forente stater, 61350
        • Radiation Oncology of Northern Illinois
      • Ottawa, Illinois, Forente stater, 61350
        • Ottawa Regional Hospital and Healthcare Center
      • Pekin, Illinois, Forente stater, 61554
        • Illinois CancerCare-Pekin
      • Pekin, Illinois, Forente stater, 61554
        • OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
      • Peoria, Illinois, Forente stater, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, Forente stater, 61637
        • OSF Saint Francis Medical Center
      • Peoria, Illinois, Forente stater, 61615
        • Illinois CancerCare-Peoria
      • Peoria, Illinois, Forente stater, 61615
        • OSF Saint Francis Radiation Oncology at Peoria Cancer Center
      • Peoria, Illinois, Forente stater, 61614
        • Proctor Hospital
      • Peru, Illinois, Forente stater, 61354
        • Illinois CancerCare-Peru
      • Peru, Illinois, Forente stater, 61354
        • Valley Radiation Oncology
      • Peru, Illinois, Forente stater, 61354
        • Illinois Valley Hospital
      • Princeton, Illinois, Forente stater, 61356
        • Illinois CancerCare-Princeton
      • Princeton, Illinois, Forente stater, 61356
        • Perry Memorial Hospital
      • Rockford, Illinois, Forente stater, 61114
        • SwedishAmerican Regional Cancer Center/ACT
      • Rockford, Illinois, Forente stater, 61104
        • Swedish American Hospital
      • Skokie, Illinois, Forente stater, 60076
        • Hematology Oncology Associates of Illinois - Skokie
      • Spring Valley, Illinois, Forente stater, 61362
        • Illinois CancerCare-Spring Valley
      • Springfield, Illinois, Forente stater, 62781
        • Memorial Medical Center
      • Urbana, Illinois, Forente stater, 61801
        • Carle Cancer Center
      • Urbana, Illinois, Forente stater, 61801
        • The Carle Foundation Hospital
      • Warrenville, Illinois, Forente stater, 60555
        • Northwestern Medicine Cancer Center Warrenville
      • Yorkville, Illinois, Forente stater, 60560
        • Rush-Copley Healthcare Center
    • Indiana
      • Beech Grove, Indiana, Forente stater, 46107
        • Franciscan Saint Francis Health-Beech Grove
      • Carmel, Indiana, Forente stater, 46032
        • IU Health North Hospital
      • Elkhart, Indiana, Forente stater, 46515
        • Elkhart General Hospital
      • Elkhart, Indiana, Forente stater, 46514
        • Michiana Hematology Oncology PC-Elkhart
      • Elkhart, Indiana, Forente stater, 46514-2098
        • Elkhart Clinic
      • Fort Wayne, Indiana, Forente stater, 46845
        • Fort Wayne Medical Oncology and Hematology Inc-Parkview
      • Indianapolis, Indiana, Forente stater, 46202
        • Indiana University/Melvin and Bren Simon Cancer Center
      • Indianapolis, Indiana, Forente stater, 46202
        • Sidney and Lois Eskenazi Hospital
      • Indianapolis, Indiana, Forente stater, 46202
        • Richard L. Roudebush Veterans Affairs Medical Center
      • Kokomo, Indiana, Forente stater, 46904
        • Community Howard Regional Health
      • La Porte, Indiana, Forente stater, 46350
        • IU Health La Porte Hospital
      • Lafayette, Indiana, Forente stater, 47904
        • IU Health Arnett Cancer Care
      • Merrillville, Indiana, Forente stater, 46410
        • Premier Oncology Hematology Associates
      • Michigan City, Indiana, Forente stater, 46360
        • Franciscan Saint Anthony Health-Michigan City
      • Michigan City, Indiana, Forente stater, 46360
        • Woodland Cancer Care Center
      • Mishawaka, Indiana, Forente stater, 46545
        • Michiana Hematology Oncology PC-Mishawaka
      • Mishawaka, Indiana, Forente stater, 46545
        • Saint Joseph Regional Medical Center-Mishawaka
      • Muncie, Indiana, Forente stater, 47303
        • IU Health Ball Memorial Hospital
      • Plymouth, Indiana, Forente stater, 46563
        • Michiana Hematology Oncology PC-Plymouth
      • Richmond, Indiana, Forente stater, 47374
        • Reid Health
      • South Bend, Indiana, Forente stater, 46601
        • Memorial Hospital of South Bend
      • South Bend, Indiana, Forente stater, 46601
        • Michiana Hematology Oncology PC-South Bend
      • South Bend, Indiana, Forente stater, 46628
        • Northern Indiana Cancer Research Consortium
      • South Bend, Indiana, Forente stater, 46617
        • South Bend Clinic
      • Westville, Indiana, Forente stater, 46391
        • Michiana Hematology Oncology PC-Westville
    • Iowa
      • Ames, Iowa, Forente stater, 50010
        • McFarland Clinic PC - Ames
      • Ames, Iowa, Forente stater, 50010
        • Mary Greeley Medical Center
      • Bettendorf, Iowa, Forente stater, 52722
        • University of Iowa Healthcare Cancer Services Quad Cities
      • Boone, Iowa, Forente stater, 50036
        • McFarland Clinic PC-Boone
      • Cedar Rapids, Iowa, Forente stater, 52403
        • Mercy Hospital
      • Cedar Rapids, Iowa, Forente stater, 52403
        • Oncology Associates at Mercy Medical Center
      • Cedar Rapids, Iowa, Forente stater, 52402
        • Saint Luke's Hospital
      • Cedar Rapids, Iowa, Forente stater, 52402
        • Physicians' Clinic of Iowa PC
      • Clive, Iowa, Forente stater, 50325
        • Mercy Cancer Center-West Lakes
      • Clive, Iowa, Forente stater, 50325
        • Medical Oncology and Hematology Associates-West Des Moines
      • Council Bluffs, Iowa, Forente stater, 51503
        • Alegent Health Mercy Hospital
      • Des Moines, Iowa, Forente stater, 50309
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, Forente stater, 50314
        • Mercy Medical Center - Des Moines
      • Des Moines, Iowa, Forente stater, 50309
        • Medical Oncology and Hematology Associates-Des Moines
      • Des Moines, Iowa, Forente stater, 50316
        • Iowa Lutheran Hospital
      • Des Moines, Iowa, Forente stater, 50309
        • Iowa-Wide Oncology Research Coalition NCORP
      • Des Moines, Iowa, Forente stater, 50314
        • Medical Oncology and Hematology Associates-Laurel
      • Des Moines, Iowa, Forente stater, 50307
        • Mercy Capitol
      • Fort Dodge, Iowa, Forente stater, 50501
        • McFarland Clinic PC-Trinity Cancer Center
      • Iowa City, Iowa, Forente stater, 52242
        • University of Iowa/Holden Comprehensive Cancer Center
      • Iowa City, Iowa, Forente stater, 52246
        • Iowa City VA Healthcare System
      • Jefferson, Iowa, Forente stater, 50129
        • McFarland Clinic PC-Jefferson
      • Marshalltown, Iowa, Forente stater, 50158
        • McFarland Clinic PC-Marshalltown
      • Mason City, Iowa, Forente stater, 50401
        • Mercy Medical Center - North Iowa
      • Ottumwa, Iowa, Forente stater, 52501
        • Ottumwa Regional Health Center
      • Sioux City, Iowa, Forente stater, 51101
        • Siouxland Regional Cancer Center
      • Sioux City, Iowa, Forente stater, 51102
        • Mercy Medical Center-Sioux City
      • Sioux City, Iowa, Forente stater, 51104
        • Saint Luke's Regional Medical Center
      • West Des Moines, Iowa, Forente stater, 50266-7700
        • Methodist West Hospital
      • West Des Moines, Iowa, Forente stater, 50266
        • Mercy Medical Center-West Lakes
    • Kansas
      • Chanute, Kansas, Forente stater, 66720
        • Cancer Center of Kansas - Chanute
      • Dodge City, Kansas, Forente stater, 67801
        • Cancer Center of Kansas - Dodge City
      • El Dorado, Kansas, Forente stater, 67042
        • Cancer Center of Kansas - El Dorado
      • Emporia, Kansas, Forente stater, 66801
        • Newman Regional Health
      • Fort Scott, Kansas, Forente stater, 66701
        • Cancer Center of Kansas - Fort Scott
      • Garden City, Kansas, Forente stater, 67846
        • Saint Catherine Hospital
      • Great Bend, Kansas, Forente stater, 67530
        • Saint Rose Ambulatory and Surgery Center
      • Hays, Kansas, Forente stater, 67601
        • HaysMed University of Kansas Health System
      • Hutchinson, Kansas, Forente stater, 67502
        • Hutchinson Regional Medical Center
      • Independence, Kansas, Forente stater, 67301
        • Cancer Center of Kansas-Independence
      • Kansas City, Kansas, Forente stater, 66160
        • University of Kansas Cancer Center
      • Kansas City, Kansas, Forente stater, 66112
        • University of Kansas Cancer Center-West
      • Kansas City, Kansas, Forente stater, 66112
        • Providence Medical Center
      • Kingman, Kansas, Forente stater, 67068
        • Cancer Center of Kansas-Kingman
      • Lawrence, Kansas, Forente stater, 66044
        • Lawrence Memorial Hospital
      • Liberal, Kansas, Forente stater, 67905
        • Cancer Center of Kansas-Liberal
      • Manhattan, Kansas, Forente stater, 66502
        • Cancer Center of Kansas-Manhattan
      • McPherson, Kansas, Forente stater, 67460
        • Cancer Center of Kansas - McPherson
      • Newton, Kansas, Forente stater, 67114
        • Cancer Center of Kansas - Newton
      • Overland Park, Kansas, Forente stater, 66210
        • University of Kansas Cancer Center-Overland Park
      • Overland Park, Kansas, Forente stater, 66209
        • Menorah Medical Center
      • Overland Park, Kansas, Forente stater, 66213
        • Saint Luke's South Hospital
      • Parsons, Kansas, Forente stater, 67357
        • Cancer Center of Kansas - Parsons
      • Pittsburg, Kansas, Forente stater, 66762
        • Ascension Via Christi - Pittsburg
      • Prairie Village, Kansas, Forente stater, 66208
        • Kansas City NCI Community Oncology Research Program
      • Pratt, Kansas, Forente stater, 67124
        • Cancer Center of Kansas - Pratt
      • Salina, Kansas, Forente stater, 67401
        • Salina Regional Health Center
      • Salina, Kansas, Forente stater, 67401
        • Cancer Center of Kansas - Salina
      • Shawnee Mission, Kansas, Forente stater, 66204
        • Advent Health - Shawnee Mission Medical Center
      • Topeka, Kansas, Forente stater, 66606
        • University of Kansas Health System Saint Francis Campus
      • Wellington, Kansas, Forente stater, 67152
        • Cancer Center of Kansas - Wellington
      • Wichita, Kansas, Forente stater, 67214
        • Ascension Via Christi Hospitals Wichita
      • Wichita, Kansas, Forente stater, 67208
        • Cancer Center of Kansas-Wichita Medical Arts Tower
      • Wichita, Kansas, Forente stater, 67214
        • Cancer Center of Kansas - Wichita
      • Wichita, Kansas, Forente stater, 67208
        • Associates In Womens Health
      • Wichita, Kansas, Forente stater, 67214
        • Wichita NCI Community Oncology Research Program
      • Wichita, Kansas, Forente stater, 67214
        • Wesley Medical Center
      • Winfield, Kansas, Forente stater, 67156
        • Cancer Center of Kansas - Winfield
    • Kentucky
      • Bardstown, Kentucky, Forente stater, 40004
        • Flaget Memorial Hospital
      • Lexington, Kentucky, Forente stater, 40536
        • University of Kentucky/Markey Cancer Center
      • Lexington, Kentucky, Forente stater, 40504
        • Saint Joseph Radiation Oncology Resource Center
      • Lexington, Kentucky, Forente stater, 40509
        • Saint Joseph Hospital East
      • Louisville, Kentucky, Forente stater, 40202
        • Jewish Hospital
      • Louisville, Kentucky, Forente stater, 40245
        • UofL Health Medical Center Northeast
      • Louisville, Kentucky, Forente stater, 40215
        • Saints Mary and Elizabeth Hospital
      • Louisville, Kentucky, Forente stater, 40215
        • Doctors Carrol, Sheth, Raghavan
      • Owensboro, Kentucky, Forente stater, 42303
        • Owensboro Health Mitchell Memorial Cancer Center
      • Shepherdsville, Kentucky, Forente stater, 40165
        • Jewish Hospital Medical Center South
    • Louisiana
      • Baton Rouge, Louisiana, Forente stater, 70809
        • Mary Bird Perkins Cancer Center
      • Baton Rouge, Louisiana, Forente stater, 70809
        • Ochsner Health Center-Summa
      • Baton Rouge, Louisiana, Forente stater, 70806
        • Baton Rouge General Medical Center
      • Metairie, Louisiana, Forente stater, 70006
        • Robert Veith MD LLC
      • New Orleans, Louisiana, Forente stater, 70121
        • Ochsner Medical Center Jefferson
      • New Orleans, Louisiana, Forente stater, 70112
        • University Medical Center New Orleans
      • New Orleans, Louisiana, Forente stater, 70112
        • Louisiana State University Health Science Center
    • Maine
      • Augusta, Maine, Forente stater, 04330
        • Harold Alfond Center for Cancer Care
      • Bangor, Maine, Forente stater, 04401
        • Eastern Maine Medical Center
      • Scarborough, Maine, Forente stater, 04074
        • Maine Center for Cancer Medicine-Scarborough
    • Maryland
      • Baltimore, Maryland, Forente stater, 21287
        • Johns Hopkins University/Sidney Kimmel Cancer Center
      • Baltimore, Maryland, Forente stater, 21201
        • University of Maryland/Greenebaum Cancer Center
      • Baltimore, Maryland, Forente stater, 21201
        • Veterans Administration Medical Center-Baltimore
      • Elkton, Maryland, Forente stater, 21921
        • Christiana Care - Union Hospital
      • Rockville, Maryland, Forente stater, 20850
        • Maryland Oncology Hematology PA-Aquilino Cancer Center
    • Massachusetts
      • Boston, Massachusetts, Forente stater, 02215
        • Beth Israel Deaconess Medical Center
      • Boston, Massachusetts, Forente stater, 02215
        • Dana-Farber Cancer Institute
      • Boston, Massachusetts, Forente stater, 02115
        • Brigham and Women's Hospital
      • Boston, Massachusetts, Forente stater, 02114
        • Massachusetts General Hospital Cancer Center
      • Brighton, Massachusetts, Forente stater, 02135
        • Steward Saint Elizabeth's Medical Center
      • Methuen, Massachusetts, Forente stater, 01844
        • Holy Family Hospital
      • Norwood, Massachusetts, Forente stater, 02062
        • Norwood Hospital
      • Springfield, Massachusetts, Forente stater, 01199
        • Baystate Medical Center
      • Worcester, Massachusetts, Forente stater, 01655
        • UMass Memorial Medical Center - University Campus
    • Michigan
      • Adrian, Michigan, Forente stater, 49221
        • Bixby Medical Center
      • Adrian, Michigan, Forente stater, 49221
        • Hickman Cancer Center
      • Ann Arbor, Michigan, Forente stater, 48106
        • Saint Joseph Mercy Hospital
      • Ann Arbor, Michigan, Forente stater, 48106
        • Michigan Cancer Research Consortium NCORP
      • Battle Creek, Michigan, Forente stater, 49017
        • Bronson Battle Creek
      • Big Rapids, Michigan, Forente stater, 49307
        • Spectrum Health Big Rapids Hospital
      • Dearborn, Michigan, Forente stater, 48124
        • Beaumont Hospital - Dearborn
      • Detroit, Michigan, Forente stater, 48202
        • Henry Ford Hospital
      • Detroit, Michigan, Forente stater, 48236
        • Ascension Saint John Hospital
      • Escanaba, Michigan, Forente stater, 49829
        • Green Bay Oncology - Escanaba
      • Flint, Michigan, Forente stater, 48532
        • Genesys Regional Medical Center-West Flint Campus
      • Flint, Michigan, Forente stater, 48503
        • Hurley Medical Center
      • Flint, Michigan, Forente stater, 48503
        • Genesys Hurley Cancer Institute
      • Grand Rapids, Michigan, Forente stater, 49503
        • Spectrum Health at Butterworth Campus
      • Grand Rapids, Michigan, Forente stater, 49503
        • Mercy Health Saint Mary's
      • Grand Rapids, Michigan, Forente stater, 49503
        • Cancer Research Consortium of West Michigan NCORP
      • Iron Mountain, Michigan, Forente stater, 49801
        • Green Bay Oncology - Iron Mountain
      • Jackson, Michigan, Forente stater, 49201
        • Allegiance Health
      • Kalamazoo, Michigan, Forente stater, 49007
        • West Michigan Cancer Center
      • Kalamazoo, Michigan, Forente stater, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, Forente stater, 49048
        • Borgess Medical Center
      • Lansing, Michigan, Forente stater, 48912
        • Sparrow Hospital
      • Livonia, Michigan, Forente stater, 48154
        • Trinity Health Saint Mary Mercy Livonia Hospital
      • Marquette, Michigan, Forente stater, 49855
        • UP Health System Marquette
      • Monroe, Michigan, Forente stater, 48162
        • Mercy Memorial Hospital
      • Monroe, Michigan, Forente stater, 48162
        • Toledo Clinic Cancer Centers-Monroe
      • Muskegon, Michigan, Forente stater, 49444
        • Mercy Health Mercy Campus
      • Niles, Michigan, Forente stater, 49120
        • Lakeland Hospital Niles
      • Pontiac, Michigan, Forente stater, 48341
        • Saint Joseph Mercy Oakland
      • Port Huron, Michigan, Forente stater, 48060
        • Lake Huron Medical Center
      • Reed City, Michigan, Forente stater, 49677
        • Spectrum Health Reed City Hospital
      • Royal Oak, Michigan, Forente stater, 48073
        • William Beaumont Hospital-Royal Oak
      • Saginaw, Michigan, Forente stater, 48601
        • Ascension Saint Mary's Hospital
      • Saint Joseph, Michigan, Forente stater, 49085
        • Lakeland Medical Center Saint Joseph
      • Saint Joseph, Michigan, Forente stater, 49085
        • Marie Yeager Cancer Center
      • Traverse City, Michigan, Forente stater, 49684
        • Munson Medical Center
      • Warren, Michigan, Forente stater, 48093
        • Saint John Macomb-Oakland Hospital
    • Minnesota
      • Alexandria, Minnesota, Forente stater, 56308
        • Medini, Eitan MD (UIA Investigator)
      • Bemidji, Minnesota, Forente stater, 56601
        • Sanford Joe Lueken Cancer Center
      • Burnsville, Minnesota, Forente stater, 55337
        • Fairview Ridges Hospital
      • Coon Rapids, Minnesota, Forente stater, 55433
        • Mercy Hospital
      • Duluth, Minnesota, Forente stater, 55805
        • Essentia Health Cancer Center
      • Duluth, Minnesota, Forente stater, 55805
        • Essentia Health Saint Mary's Medical Center
      • Duluth, Minnesota, Forente stater, 55805
        • Miller-Dwan Hospital
      • Edina, Minnesota, Forente stater, 55435
        • Fairview Southdale Hospital
      • Fergus Falls, Minnesota, Forente stater, 56537
        • Lake Region Healthcare Corporation-Cancer Care
      • Fridley, Minnesota, Forente stater, 55432
        • Unity Hospital
      • Hutchinson, Minnesota, Forente stater, 55350
        • Hutchinson Area Health Care
      • Maplewood, Minnesota, Forente stater, 55109
        • Saint John's Hospital - Healtheast
      • Maplewood, Minnesota, Forente stater, 55109
        • Minnesota Oncology Hematology PA-Maplewood
      • Minneapolis, Minnesota, Forente stater, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, Forente stater, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, Forente stater, 55454
        • Health Partners Inc
      • Minneapolis, Minnesota, Forente stater, 55455
        • University of Minnesota/Masonic Cancer Center
      • New Ulm, Minnesota, Forente stater, 56073
        • New Ulm Medical Center
      • Robbinsdale, Minnesota, Forente stater, 55422
        • North Memorial Medical Health Center
      • Rochester, Minnesota, Forente stater, 55905
        • Mayo Clinic in Rochester
      • Saint Cloud, Minnesota, Forente stater, 56303
        • Coborn Cancer Center at Saint Cloud Hospital
      • Saint Cloud, Minnesota, Forente stater, 56303
        • Saint Cloud Hospital
      • Saint Louis Park, Minnesota, Forente stater, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Louis Park, Minnesota, Forente stater, 55416
        • Metro Minnesota Community Oncology Research Consortium
      • Saint Paul, Minnesota, Forente stater, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, Forente stater, 55102
        • United Hospital
      • Shakopee, Minnesota, Forente stater, 55379
        • Saint Francis Regional Medical Center
      • Stillwater, Minnesota, Forente stater, 55082
        • Lakeview Hospital
      • Waconia, Minnesota, Forente stater, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, Forente stater, 56201
        • Rice Memorial Hospital
      • Woodbury, Minnesota, Forente stater, 55125
        • Minnesota Oncology Hematology PA-Woodbury
    • Mississippi
      • Hattiesburg, Mississippi, Forente stater, 39401
        • Hattiesburg Clinic - Hematology/Oncology Clinic
      • Hattiesburg, Mississippi, Forente stater, 39404
        • Forrest General Hospital / Cancer Center
      • Jackson, Mississippi, Forente stater, 39216
        • University of Mississippi Medical Center
    • Missouri
      • Bolivar, Missouri, Forente stater, 65613
        • Central Care Cancer Center - Bolivar
      • Bonne Terre, Missouri, Forente stater, 63628
        • Parkland Health Center-Bonne Terre
      • Branson, Missouri, Forente stater, 65616
        • Cox Cancer Center Branson
      • Cape Girardeau, Missouri, Forente stater, 63703
        • Saint Francis Medical Center
      • Cape Girardeau, Missouri, Forente stater, 63703
        • Southeast Cancer Center
      • Columbia, Missouri, Forente stater, 65212
        • University of Missouri - Ellis Fischel
      • Columbia, Missouri, Forente stater, 65201
        • Veterans Administration
      • Independence, Missouri, Forente stater, 64057
        • Centerpoint Medical Center LLC
      • Jefferson City, Missouri, Forente stater, 65109
        • Capital Region Southwest Campus
      • Joplin, Missouri, Forente stater, 64804
        • Freeman Health System
      • Joplin, Missouri, Forente stater, 64804
        • Mercy Hospital Joplin
      • Kansas City, Missouri, Forente stater, 64128
        • Kansas City Veterans Affairs Medical Center
      • Kansas City, Missouri, Forente stater, 64154
        • University of Kansas Cancer Center - North
      • Kansas City, Missouri, Forente stater, 64116
        • North Kansas City Hospital
      • Kansas City, Missouri, Forente stater, 64131
        • The University of Kansas Cancer Center-South
      • Kansas City, Missouri, Forente stater, 64111
        • Saint Luke's Hospital of Kansas City
      • Kansas City, Missouri, Forente stater, 64132
        • Research Medical Center
      • Kansas City, Missouri, Forente stater, 64108
        • Truman Medical Centers
      • Kansas City, Missouri, Forente stater, 64118
        • Heartland Hematology and Oncology Associates Incorporated
      • Kansas City, Missouri, Forente stater, 64114
        • Saint Joseph Health Center
      • Lee's Summit, Missouri, Forente stater, 64064
        • University of Kansas Cancer Center - Lee's Summit
      • Lee's Summit, Missouri, Forente stater, 64086
        • Saint Luke's East - Lee's Summit
      • Liberty, Missouri, Forente stater, 64068
        • Liberty Radiation Oncology Center
      • Rolla, Missouri, Forente stater, 65401
        • Delbert Day Cancer Institute at PCRMC
      • Rolla, Missouri, Forente stater, 65401
        • Mercy Clinic-Rolla-Cancer and Hematology
      • Saint Joseph, Missouri, Forente stater, 64506
        • Heartland Regional Medical Center
      • Saint Joseph, Missouri, Forente stater, 64507
        • Saint Joseph Oncology Inc
      • Saint Louis, Missouri, Forente stater, 63110
        • Washington University School of Medicine
      • Saint Louis, Missouri, Forente stater, 63131
        • Missouri Baptist Medical Center
      • Saint Louis, Missouri, Forente stater, 63141
        • Mercy Hospital Saint Louis
      • Saint Louis, Missouri, Forente stater, 63109
        • Saint Louis Cancer and Breast Institute-South City
      • Saint Louis, Missouri, Forente stater, 63141
        • Saint Louis-Cape Girardeau CCOP
      • Saint Louis, Missouri, Forente stater, 63104
        • SSM Health Saint Louis University Hospital
      • Saint Louis, Missouri, Forente stater, 63141
        • Center for Cancer Care and Research
      • Saint Louis, Missouri, Forente stater, 63141
        • Comprehensive Cancer Care PC
      • Sainte Genevieve, Missouri, Forente stater, 63670
        • Sainte Genevieve County Memorial Hospital
      • Springfield, Missouri, Forente stater, 65804
        • Cancer Research for the Ozarks NCORP
      • Springfield, Missouri, Forente stater, 65807
        • CoxHealth South Hospital
      • Springfield, Missouri, Forente stater, 65804
        • Mercy Hospital Springfield
      • Sullivan, Missouri, Forente stater, 63080
        • Missouri Baptist Sullivan Hospital
      • Sunset Hills, Missouri, Forente stater, 63127
        • Missouri Baptist Outpatient Center-Sunset Hills
    • Montana
      • Billings, Montana, Forente stater, 59101
        • Billings Clinic Cancer Center
      • Billings, Montana, Forente stater, 59101
        • Saint Vincent Healthcare
      • Billings, Montana, Forente stater, 59102
        • Montana Cancer Consortium NCORP
      • Billings, Montana, Forente stater, 59101
        • Northern Rockies Radiation Oncology Center
      • Billings, Montana, Forente stater, 59102
        • Saint Vincent Frontier Cancer Center
      • Bozeman, Montana, Forente stater, 59715
        • Bozeman Deaconess Hospital
      • Butte, Montana, Forente stater, 59701
        • Saint James Community Hospital and Cancer Treatment Center
      • Great Falls, Montana, Forente stater, 59405
        • Great Falls Clinic
      • Great Falls, Montana, Forente stater, 59405
        • Benefis Healthcare- Sletten Cancer Institute
      • Great Falls, Montana, Forente stater, 59405
        • Berdeaux, Donald MD (UIA Investigator)
      • Havre, Montana, Forente stater, 59501
        • Northern Montana Hospital
      • Helena, Montana, Forente stater, 59601
        • Saint Peter's Community Hospital
      • Kalispell, Montana, Forente stater, 59901
        • Kalispell Regional Medical Center
      • Kalispell, Montana, Forente stater, 59901
        • Glacier Oncology PLLC
      • Kalispell, Montana, Forente stater, 59901
        • Kalispell Medical Oncology
      • Missoula, Montana, Forente stater, 59804
        • Community Medical Hospital
      • Missoula, Montana, Forente stater, 59802
        • Saint Patrick Hospital - Community Hospital
      • Missoula, Montana, Forente stater, 59804
        • Guardian Oncology and Center for Wellness
      • Missoula, Montana, Forente stater, 59802
        • Montana Cancer Specialists
    • Nebraska
      • Grand Island, Nebraska, Forente stater, 68803
        • CHI Health Saint Francis
      • Kearney, Nebraska, Forente stater, 68847
        • CHI Health Good Samaritan
      • Kearney, Nebraska, Forente stater, 68845
        • Heartland Hematology and Oncology
      • Lincoln, Nebraska, Forente stater, 68510
        • Nebraska Cancer Research Center
      • Lincoln, Nebraska, Forente stater, 68510
        • Saint Elizabeth Regional Medical Center
      • North Platte, Nebraska, Forente stater, 69101
        • Great Plains Health Callahan Cancer Center
      • Omaha, Nebraska, Forente stater, 68114
        • Nebraska Methodist Hospital
      • Omaha, Nebraska, Forente stater, 68198
        • University Of Nebraska Medical Center
      • Omaha, Nebraska, Forente stater, 68124
        • Alegent Health Bergan Mercy Medical Center
      • Omaha, Nebraska, Forente stater, 68122
        • Alegent Health Immanuel Medical Center
      • Omaha, Nebraska, Forente stater, 68130
        • Alegent Health Lakeside Hospital
      • Omaha, Nebraska, Forente stater, 68131
        • Creighton University Medical Center
      • Omaha, Nebraska, Forente stater, 68106
        • Missouri Valley Cancer Consortium
      • Omaha, Nebraska, Forente stater, 68122
        • Hematology and Oncology Consultants PC
      • Papillion, Nebraska, Forente stater, 68046
        • Midlands Community Hospital
    • Nevada
      • Henderson, Nevada, Forente stater, 89052
        • Comprehensive Cancer Centers of Nevada - Henderson
      • Henderson, Nevada, Forente stater, 89052
        • Cancer and Blood Specialists-Henderson
      • Henderson, Nevada, Forente stater, 89052
        • Las Vegas Cancer Center-Henderson
      • Henderson, Nevada, Forente stater, 89074
        • Comprehensive Cancer Centers of Nevada-Southeast Henderson
      • Henderson, Nevada, Forente stater, 89074
        • GenesisCare USA - Henderson
      • Las Vegas, Nevada, Forente stater, 89144
        • Summerlin Hospital Medical Center
      • Las Vegas, Nevada, Forente stater, 89106
        • Radiation Oncology Centers of Nevada Central
      • Las Vegas, Nevada, Forente stater, 89109
        • GenesisCare USA - Las Vegas
      • Las Vegas, Nevada, Forente stater, 89119
        • Radiation Oncology Centers of Nevada Southeast
      • Las Vegas, Nevada, Forente stater, 89128
        • Comprehensive Cancer Centers of Nevada - Northwest
      • Las Vegas, Nevada, Forente stater, 89135
        • Alliance for Childhood Diseases/Cure 4 the Kids Foundation
      • Las Vegas, Nevada, Forente stater, 89144
        • Comprehensive Cancer Centers of Nevada-Summerlin
      • Las Vegas, Nevada, Forente stater, 89148
        • Comprehensive Cancer Centers of Nevada
      • Las Vegas, Nevada, Forente stater, 89148
        • OptumCare Cancer Care at Fort Apache
      • Las Vegas, Nevada, Forente stater, 89169
        • Comprehensive Cancer Centers of Nevada - Central Valley
      • Las Vegas, Nevada, Forente stater, 89102
        • University Medical Center of Southern Nevada
      • Las Vegas, Nevada, Forente stater, 89106
        • Cancer and Blood Specialists-Shadow
      • Las Vegas, Nevada, Forente stater, 89109
        • HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
      • Las Vegas, Nevada, Forente stater, 89113
        • HealthCare Partners Medical Group Oncology/Hematology-San Martin
      • Las Vegas, Nevada, Forente stater, 89121
        • Cancer Therapy and Integrative Medicine
      • Las Vegas, Nevada, Forente stater, 89128
        • Cancer and Blood Specialists-Tenaya
      • Las Vegas, Nevada, Forente stater, 89128
        • GenesisCare USA - Vegas Tenaya
      • Las Vegas, Nevada, Forente stater, 89128
        • HealthCare Partners Medical Group Oncology/Hematology-Tenaya
      • Las Vegas, Nevada, Forente stater, 89148-2405
        • Las Vegas Cancer Center-Medical Center
      • Las Vegas, Nevada, Forente stater, 89148
        • GenesisCare USA - Fort Apache
      • Las Vegas, Nevada, Forente stater, 89149
        • HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
      • Las Vegas, Nevada, Forente stater, 89169
        • Nevada Cancer Research Foundation NCORP
      • Las Vegas, Nevada, Forente stater, 89135
        • Nevada Cancer Institute-Summerlin Campus
    • New Hampshire
      • Concord, New Hampshire, Forente stater, 03301
        • New Hampshire Oncology Hematology PA-Concord
      • Laconia, New Hampshire, Forente stater, 03246
        • LRGHealthcare-Lakes Region General Hospital
      • Lebanon, New Hampshire, Forente stater, 03756
        • Dartmouth Hitchcock Medical Center
      • Londonderry, New Hampshire, Forente stater, 03053
        • The Dana-Farber Cancer Institute at Londonderry
      • Manchester, New Hampshire, Forente stater, 03103
        • Solinsky Center for Cancer Care
    • New Jersey
      • Basking Ridge, New Jersey, Forente stater, 07920
        • Memorial Sloan Kettering Basking Ridge
      • Camden, New Jersey, Forente stater, 08103
        • Cooper Hospital University Medical Center
      • East Orange, New Jersey, Forente stater, 07018-1095
        • Veterans Adminstration New Jersey Health Care System
      • Hackensack, New Jersey, Forente stater, 07601
        • Hackensack University Medical Center
      • Morristown, New Jersey, Forente stater, 07960
        • Morristown Medical Center
      • Mount Holly, New Jersey, Forente stater, 08060
        • Virtua Memorial
      • Newark, New Jersey, Forente stater, 07101
        • Rutgers New Jersey Medical School
      • Pennington, New Jersey, Forente stater, 08534
        • Capital Health Medical Center-Hopewell
      • Somerville, New Jersey, Forente stater, 08876
        • Robert Wood Johnson University Hospital Somerset
      • Summit, New Jersey, Forente stater, 07902
        • Overlook Hospital
      • Vineland, New Jersey, Forente stater, 08360
        • Inspira Medical Center Vineland
      • Voorhees, New Jersey, Forente stater, 08043
        • Virtua Voorhees
      • Voorhees, New Jersey, Forente stater, 08043
        • MD Anderson Cancer Center at Cooper-Voorhees
    • New Mexico
      • Albuquerque, New Mexico, Forente stater, 87102
        • University of New Mexico Cancer Center
    • New York
      • Auburn, New York, Forente stater, 13021
        • Hematology Oncology Associates of Central New York-Auburn
      • Brooklyn, New York, Forente stater, 11209
        • Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus
      • Buffalo, New York, Forente stater, 14263
        • Roswell Park Cancer Institute
      • Buffalo, New York, Forente stater, 14215
        • Veterans Affairs Western New York Health Care System-Buffalo
      • Commack, New York, Forente stater, 11725
        • Memorial Sloan Kettering Commack
      • East Syracuse, New York, Forente stater, 13057
        • Hematology Oncology Associates of Central New York-East Syracuse
      • Glens Falls, New York, Forente stater, 12801
        • Glens Falls Hospital
      • Middletown, New York, Forente stater, 10940
        • Garnet Health Medical Center
      • New York, New York, Forente stater, 10065
        • Memorial Sloan Kettering Cancer Center
      • New York, New York, Forente stater, 10019
        • Mount Sinai West
      • New York, New York, Forente stater, 10032
        • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
      • New York, New York, Forente stater, 10065
        • NYP/Weill Cornell Medical Center
      • New York, New York, Forente stater, 10016
        • Laura and Isaac Perlmutter Cancer Center at NYU Langone
      • New York, New York, Forente stater, 10003
        • Mount Sinai Union Square
      • Rochester, New York, Forente stater, 14642
        • University of Rochester
      • Rochester, New York, Forente stater, 14623
        • Interlakes Foundation Inc-Rochester
      • Sleepy Hollow, New York, Forente stater, 10591
        • Memorial Sloan Kettering Sleepy Hollow
      • Staten Island, New York, Forente stater, 10305
        • Staten Island University Hospital
      • Syracuse, New York, Forente stater, 13210
        • State University of New York Upstate Medical University
      • Syracuse, New York, Forente stater, 13215
        • Hematology Oncology Associates of Central New York-Onondaga Hill
      • Uniondale, New York, Forente stater, 11553
        • Memorial Sloan Kettering Nassau
    • North Carolina
      • Asheboro, North Carolina, Forente stater, 27203
        • Randolph Hospital
      • Chapel Hill, North Carolina, Forente stater, 27599
        • UNC Lineberger Comprehensive Cancer Center
      • Charlotte, North Carolina, Forente stater, 28203
        • Carolinas Medical Center/Levine Cancer Institute
      • Charlotte, North Carolina, Forente stater, 28204
        • Novant Health Presbyterian Medical Center
      • Clinton, North Carolina, Forente stater, 28328
        • Southeastern Medical Oncology Center-Clinton
      • Concord, North Carolina, Forente stater, 28025
        • Atrium Health Cabarrus/LCI-Concord
      • Durham, North Carolina, Forente stater, 27710
        • Duke University Medical Center
      • Goldsboro, North Carolina, Forente stater, 27534
        • Southeastern Medical Oncology Center-Goldsboro
      • Goldsboro, North Carolina, Forente stater, 27534
        • Wayne Memorial Hospital
      • Greensboro, North Carolina, Forente stater, 27403
        • Cone Health Cancer Center
      • Greenville, North Carolina, Forente stater, 27834
        • East Carolina University
      • Hendersonville, North Carolina, Forente stater, 28791
        • Hendersonville Hematology and Oncology at Pardee
      • Hendersonville, North Carolina, Forente stater, 28791
        • Margaret R Pardee Memorial Hospital
      • Hendersonville, North Carolina, Forente stater, 28792
        • AdventHealth Hendersonville
      • High Point, North Carolina, Forente stater, 27262
        • High Point Regional Hospital
      • Jacksonville, North Carolina, Forente stater, 28546
        • Southeastern Medical Oncology Center-Jacksonville
      • Kinston, North Carolina, Forente stater, 28501
        • Vidant Oncology-Kinston
      • Lumberton, North Carolina, Forente stater, 28358
        • Southeastern Regional Medical Center
      • Monroe, North Carolina, Forente stater, 28112
        • Atrium Health Union/LCI-Union
      • Oxford, North Carolina, Forente stater, 27565
        • Granville Medical Center
      • Pinehurst, North Carolina, Forente stater, 28374
        • FirstHealth of the Carolinas-Moore Regional Hospital
      • Raleigh, North Carolina, Forente stater, 27609
        • Duke Raleigh Hospital
      • Reidsville, North Carolina, Forente stater, 27320
        • Annie Penn Memorial Hospital
      • Roxboro, North Carolina, Forente stater, 27573
        • Person Memorial Hospital
      • Rutherfordton, North Carolina, Forente stater, 28139
        • Rutherford Hospital
      • Shelby, North Carolina, Forente stater, 28150
        • Atrium Health Cleveland/LCI-Cleveland
      • Statesville, North Carolina, Forente stater, 28677
        • Iredell Memorial Hospital
      • Winston-Salem, North Carolina, Forente stater, 27157
        • Wake Forest University Health Sciences
      • Winston-Salem, North Carolina, Forente stater, 27104
        • Southeast Clinical Oncology Research Consortium NCORP
    • North Dakota
      • Bismarck, North Dakota, Forente stater, 58501
        • Sanford Bismarck Medical Center
      • Bismarck, North Dakota, Forente stater, 58501
        • Mid Dakota Clinic
      • Bismarck, North Dakota, Forente stater, 58501
        • Saint Alexius Medical Center
      • Fargo, North Dakota, Forente stater, 58122
        • Sanford Roger Maris Cancer Center
      • Fargo, North Dakota, Forente stater, 58122
        • Sanford Broadway Medical Center
      • Fargo, North Dakota, Forente stater, 58122
        • Sanford Clinic North-Fargo
    • Ohio
      • Akron, Ohio, Forente stater, 44307
        • Cleveland Clinic Akron General
      • Beachwood, Ohio, Forente stater, 44122
        • UHHS-Chagrin Highlands Medical Center
      • Beachwood, Ohio, Forente stater, 44122
        • Cleveland Clinic Cancer Center Beachwood
      • Bellefontaine, Ohio, Forente stater, 43311
        • Mary Rutan Hospital
      • Belpre, Ohio, Forente stater, 45714
        • Strecker Cancer Center-Belpre
      • Bowling Green, Ohio, Forente stater, 43402
        • Toledo Clinic Cancer Centers-Bowling Green
      • Canton, Ohio, Forente stater, 44708
        • Cleveland Clinic Mercy Hospital
      • Canton, Ohio, Forente stater, 44710
        • Aultman Health Foundation
      • Chardon, Ohio, Forente stater, 44024
        • Geauga Hospital
      • Chillicothe, Ohio, Forente stater, 45601
        • Adena Regional Medical Center
      • Cincinnati, Ohio, Forente stater, 45219
        • University of Cincinnati Cancer Center-UC Medical Center
      • Cincinnati, Ohio, Forente stater, 45220
        • Good Samaritan Hospital - Cincinnati
      • Cincinnati, Ohio, Forente stater, 45242
        • Bethesda North Hospital
      • Cincinnati, Ohio, Forente stater, 45247
        • TriHealth Cancer Institute-Westside
      • Cincinnati, Ohio, Forente stater, 45255
        • TriHealth Cancer Institute-Anderson
      • Cleveland, Ohio, Forente stater, 44106
        • Case Western Reserve University
      • Cleveland, Ohio, Forente stater, 44109
        • MetroHealth Medical Center
      • Cleveland, Ohio, Forente stater, 44195
        • Cleveland Clinic Foundation
      • Cleveland, Ohio, Forente stater, 44111
        • Cleveland Clinic Cancer Center/Fairview Hospital
      • Clyde, Ohio, Forente stater, 43410
        • North Coast Cancer Care-Clyde
      • Columbus, Ohio, Forente stater, 43214
        • Riverside Methodist Hospital
      • Columbus, Ohio, Forente stater, 43210
        • Ohio State University Comprehensive Cancer Center
      • Columbus, Ohio, Forente stater, 43219
        • The Mark H Zangmeister Center
      • Columbus, Ohio, Forente stater, 43214
        • Columbus Oncology and Hematology Associates Inc
      • Columbus, Ohio, Forente stater, 43228
        • Doctors Hospital
      • Columbus, Ohio, Forente stater, 43213
        • Mount Carmel East Hospital
      • Columbus, Ohio, Forente stater, 43215
        • Grant Medical Center
      • Columbus, Ohio, Forente stater, 43222
        • Mount Carmel Health Center West
      • Columbus, Ohio, Forente stater, 43215
        • Columbus NCI Community Oncology Research Program
      • Dayton, Ohio, Forente stater, 45406
        • Good Samaritan Hospital - Dayton
      • Dayton, Ohio, Forente stater, 45409
        • Miami Valley Hospital
      • Dayton, Ohio, Forente stater, 45415
        • Miami Valley Hospital North
      • Dayton, Ohio, Forente stater, 45405
        • Grandview Hospital
      • Dayton, Ohio, Forente stater, 45428
        • Dayton Veterans Affairs Medical Center
      • Delaware, Ohio, Forente stater, 43015
        • Delaware Health Center-Grady Cancer Center
      • Delaware, Ohio, Forente stater, 43015
        • Delaware Radiation Oncology
      • Delaware, Ohio, Forente stater, 43015
        • Grady Memorial Hospital
      • Elyria, Ohio, Forente stater, 44035
        • Mercy Cancer Center-Elyria
      • Elyria, Ohio, Forente stater, 44035
        • Hematology Oncology Center Incorporated
      • Findlay, Ohio, Forente stater, 45840
        • Blanchard Valley Hospital
      • Franklin, Ohio, Forente stater, 45005-1066
        • Atrium Medical Center-Middletown Regional Hospital
      • Greenville, Ohio, Forente stater, 45331
        • Wayne Hospital
      • Independence, Ohio, Forente stater, 44131
        • Cleveland Clinic Cancer Center Independence
      • Kettering, Ohio, Forente stater, 45429
        • Kettering Medical Center
      • Lancaster, Ohio, Forente stater, 43130
        • Fairfield Medical Center
      • Lancaster, Ohio, Forente stater, 43130
        • Lancaster Radiation Oncology
      • Lima, Ohio, Forente stater, 45801
        • Saint Rita's Medical Center
      • Lima, Ohio, Forente stater, 45804
        • Lima Memorial Hospital
      • Marietta, Ohio, Forente stater, 45750
        • Marietta Memorial Hospital
      • Maumee, Ohio, Forente stater, 43537
        • Toledo Clinic Cancer Centers-Maumee
      • Maumee, Ohio, Forente stater, 43537
        • Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
      • Maumee, Ohio, Forente stater, 43537
        • Saint Luke's Hospital
      • Mayfield Heights, Ohio, Forente stater, 44124
        • Hillcrest Hospital Cancer Center
      • Mayfield Heights, Ohio, Forente stater, 44124
        • UH Seidman Cancer Center at Landerbrook Health Center
      • Mentor, Ohio, Forente stater, 44060
        • UH Seidman Cancer Center at Lake Health Mentor Campus
      • Middleburg Heights, Ohio, Forente stater, 44130
        • UH Seidman Cancer Center at Southwest General Hospital
      • Mount Vernon, Ohio, Forente stater, 43050
        • Knox Community Hospital
      • Newark, Ohio, Forente stater, 43055
        • Licking Memorial Hospital
      • Newark, Ohio, Forente stater, 43055
        • Newark Radiation Oncology
      • Norwalk, Ohio, Forente stater, 44857
        • Fisher-Titus Medical Center
      • Oregon, Ohio, Forente stater, 43616
        • Saint Charles Hospital
      • Oregon, Ohio, Forente stater, 43616
        • Toledo Clinic Cancer Centers-Oregon
      • Parma, Ohio, Forente stater, 44129
        • University Hospitals Parma Medical Center
      • Portsmouth, Ohio, Forente stater, 45662
        • Southern Ohio Medical Center
      • Sandusky, Ohio, Forente stater, 44870
        • North Coast Cancer Care
      • Sandusky, Ohio, Forente stater, 44870
        • UH Seidman Cancer Center at Firelands Regional Medical Center
      • Springfield, Ohio, Forente stater, 45505
        • Springfield Regional Medical Center
      • Strongsville, Ohio, Forente stater, 44136
        • Cleveland Clinic Cancer Center Strongsville
      • Sylvania, Ohio, Forente stater, 43560
        • ProMedica Flower Hospital
      • Tiffin, Ohio, Forente stater, 44883
        • Mercy Hospital of Tiffin
      • Toledo, Ohio, Forente stater, 43606
        • ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
      • Toledo, Ohio, Forente stater, 43608
        • Saint Vincent Mercy Medical Center
      • Toledo, Ohio, Forente stater, 43623
        • Mercy Health - Saint Anne Hospital
      • Toledo, Ohio, Forente stater, 43623
        • Toledo Clinic Cancer Centers-Toledo
      • Toledo, Ohio, Forente stater, 43614
        • University of Toledo
      • Toledo, Ohio, Forente stater, 43617
        • Toledo Community Hospital Oncology Program CCOP
      • Troy, Ohio, Forente stater, 45373
        • Upper Valley Medical Center
      • Wauseon, Ohio, Forente stater, 43567
        • Fulton County Health Center
      • Westerville, Ohio, Forente stater, 43081
        • Saint Ann's Hospital
      • Westlake, Ohio, Forente stater, 44145
        • UH Seidman Cancer Center at Saint John Medical Center
      • Westlake, Ohio, Forente stater, 44145
        • UHHS-Westlake Medical Center
      • Wilmington, Ohio, Forente stater, 45177
        • Clinton Memorial Hospital
      • Wooster, Ohio, Forente stater, 44691
        • Cleveland Clinic Wooster Family Health and Surgery Center
      • Xenia, Ohio, Forente stater, 45385
        • Greene Memorial Hospital
      • Zanesville, Ohio, Forente stater, 43701
        • Genesis Healthcare System Cancer Care Center
    • Oklahoma
      • Lawton, Oklahoma, Forente stater, 73505
        • Cancer Centers of Southwest Oklahoma Research
      • Norman, Oklahoma, Forente stater, 73071
        • Cancer Care Associates-Norman
      • Oklahoma City, Oklahoma, Forente stater, 73104
        • University of Oklahoma Health Sciences Center
      • Oklahoma City, Oklahoma, Forente stater, 73120
        • Mercy Physicians of Oklahoma-Lakeside
      • Tulsa, Oklahoma, Forente stater, 74146
        • Oklahoma Cancer Specialists and Research Institute-Tulsa
      • Tulsa, Oklahoma, Forente stater, 74136
        • Natalie Warren Bryant Cancer Center at Saint Francis
      • Tulsa, Oklahoma, Forente stater, 74146
        • Warren Clinic Oncology-Tulsa
    • Oregon
      • Corvallis, Oregon, Forente stater, 97330
        • Good Samaritan Hospital
    • Pennsylvania
      • Abington, Pennsylvania, Forente stater, 19001
        • Jefferson Abington Hospital
      • Allentown, Pennsylvania, Forente stater, 18103
        • Lehigh Valley Hospital-Cedar Crest
      • Bethlehem, Pennsylvania, Forente stater, 18017
        • Lehigh Valley Hospital - Muhlenberg
      • Butler, Pennsylvania, Forente stater, 16001
        • Butler Memorial Hospital
      • Danville, Pennsylvania, Forente stater, 17822
        • Geisinger Medical Center
      • Doylestown, Pennsylvania, Forente stater, 18901
        • Doylestown Hospital
      • Hazleton, Pennsylvania, Forente stater, 18201
        • Geisinger Medical Center-Cancer Center Hazleton
      • Lewisburg, Pennsylvania, Forente stater, 17837
        • Geisinger Medical Oncology-Lewisburg
      • Lewistown, Pennsylvania, Forente stater, 17044
        • Lewistown Hospital
      • Philadelphia, Pennsylvania, Forente stater, 19111
        • Fox Chase Cancer Center
      • Philadelphia, Pennsylvania, Forente stater, 19114
        • Jefferson Torresdale Hospital
      • Philadelphia, Pennsylvania, Forente stater, 19107
        • Pennsylvania Hospital
      • Pottstown, Pennsylvania, Forente stater, 19464
        • Pottstown Hospital
      • Pottsville, Pennsylvania, Forente stater, 17901
        • Geisinger Cancer Services-Pottsville
      • Sayre, Pennsylvania, Forente stater, 18840
        • Guthrie Medical Group PC-Robert Packer Hospital
      • State College, Pennsylvania, Forente stater, 16801
        • Geisinger Medical Group
      • West Reading, Pennsylvania, Forente stater, 19611
        • Reading Hospital
      • Wilkes-Barre, Pennsylvania, Forente stater, 18711
        • Geisinger Wyoming Valley/Henry Cancer Center
      • Williamsport, Pennsylvania, Forente stater, 17701
        • UPMC Susquehanna
    • South Carolina
      • Anderson, South Carolina, Forente stater, 29621
        • AnMed Health Cancer Center
      • Anderson, South Carolina, Forente stater, 29621
        • AnMed Health Hospital
      • Boiling Springs, South Carolina, Forente stater, 29316
        • Prisma Health Cancer Institute - Spartanburg
      • Charleston, South Carolina, Forente stater, 29425
        • Medical University of South Carolina
      • Charleston, South Carolina, Forente stater, 29401
        • Roper Hospital
      • Charleston, South Carolina, Forente stater, 29406
        • Lowcountry Hematology Oncology PA-North Charleston
      • Charleston, South Carolina, Forente stater, 29414
        • Lowcountry Hematology Oncology PA-West Ashley
      • Charleston, South Carolina, Forente stater, 29403
        • Charleston Oncology - Roper
      • Charleston, South Carolina, Forente stater, 29414
        • Charleston Oncology - Saint Francis
      • Easley, South Carolina, Forente stater, 29640
        • Prisma Health Cancer Institute - Easley
      • Greenville, South Carolina, Forente stater, 29605
        • Prisma Health Cancer Institute - Faris
      • Greenville, South Carolina, Forente stater, 29615
        • Prisma Health Cancer Institute - Eastside
      • Greenville, South Carolina, Forente stater, 29605
        • Prisma Health Cancer Institute - Butternut
      • Greenville, South Carolina, Forente stater, 29601
        • Saint Francis Hospital
      • Greenville, South Carolina, Forente stater, 29605
        • Prisma Health Greenville Memorial Hospital
      • Greenville, South Carolina, Forente stater, 29601
        • Greenville Health System Cancer Institute-Andrews
      • Greenwood, South Carolina, Forente stater, 29646
        • Self Regional Healthcare
      • Greer, South Carolina, Forente stater, 29650
        • Prisma Health Cancer Institute - Greer
      • Greer, South Carolina, Forente stater, 29651
        • Gibbs Cancer Center-Pelham
      • Lancaster, South Carolina, Forente stater, 29720
        • Carolina Blood and Cancer Care Associates PA-Lancaster
      • Mount Pleasant, South Carolina, Forente stater, 29464
        • Lowcountry Hematology Oncology PA-Mount Pleasant
      • Rock Hill, South Carolina, Forente stater, 29732
        • Carolina Blood and Cancer Care Associates PA
      • Seneca, South Carolina, Forente stater, 29672
        • Prisma Health Cancer Institute - Seneca
      • Spartanburg, South Carolina, Forente stater, 29303
        • Spartanburg Medical Center
    • South Dakota
      • Sioux Falls, South Dakota, Forente stater, 57105
        • Avera Cancer Institute
      • Sioux Falls, South Dakota, Forente stater, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, Forente stater, 57104
        • Sanford Cancer Center Oncology Clinic
      • Sioux Falls, South Dakota, Forente stater, 57105
        • Medical X-Ray Center
    • Tennessee
      • Bristol, Tennessee, Forente stater, 37620
        • Wellmont Medical Associates Oncology and Hematology-Bristol
      • Chattanooga, Tennessee, Forente stater, 37404
        • Memorial Hospital
      • Chattanooga, Tennessee, Forente stater, 37403
        • Erlanger Medical Center
      • Hixson, Tennessee, Forente stater, 37343
        • Pulmonary Medicine Center of Chattanooga-Hixson
      • Kingsport, Tennessee, Forente stater, 37660
        • Ballad Health Cancer Care - Kingsport
      • Kingsport, Tennessee, Forente stater, 37660
        • Wellmont Holston Valley Hospital and Medical Center
      • Ooltewah, Tennessee, Forente stater, 37363
        • Memorial GYN Plus
    • Texas
      • Dallas, Texas, Forente stater, 75390
        • UT Southwestern/Simmons Cancer Center-Dallas
      • Houston, Texas, Forente stater, 77030
        • Houston Methodist Hospital
      • Houston, Texas, Forente stater, 77030
        • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
      • Houston, Texas, Forente stater, 77030
        • Michael E DeBakey VA Medical Center
      • Houston, Texas, Forente stater, 77030
        • Ben Taub General Hospital
      • Houston, Texas, Forente stater, 77030
        • Baylor Saint Luke's Medical Center
    • Vermont
      • Bennington, Vermont, Forente stater, 05201
        • Southwestern Vermont Medical Center
      • Berlin, Vermont, Forente stater, 05602
        • Central Vermont Medical Center/National Life Cancer Treatment
      • Burlington, Vermont, Forente stater, 05405
        • University of Vermont and State Agricultural College
    • Virginia
      • Danville, Virginia, Forente stater, 24541
        • Danville Regional Medical Center
      • Fredericksburg, Virginia, Forente stater, 22401
        • Fredericksburg Oncology Inc
      • Fredericksburg, Virginia, Forente stater, 22408
        • Hematology Oncology Associates of Fredericksburg Inc
      • Lynchburg, Virginia, Forente stater, 24501
        • Centra Lynchburg Hematology-Oncology Clinic Inc
      • Martinsville, Virginia, Forente stater, 24115
        • Sovah Health Martinsville
      • Norton, Virginia, Forente stater, 24273
        • Southwest VA Regional Cancer Center
      • Richmond, Virginia, Forente stater, 23298
        • Virginia Commonwealth University/Massey Cancer Center
    • Washington
      • Anacortes, Washington, Forente stater, 98221
        • Cancer Care Center at Island Hospital
      • Auburn, Washington, Forente stater, 98001
        • MultiCare Auburn Medical Center
      • Bellevue, Washington, Forente stater, 98004
        • Overlake Medical Center
      • Bellingham, Washington, Forente stater, 98225
        • PeaceHealth Saint Joseph Medical Center
      • Bremerton, Washington, Forente stater, 98310
        • Harrison HealthPartners Hematology and Oncology-Bremerton
      • Burien, Washington, Forente stater, 98166
        • Highline Medical Center-Main Campus
      • Centralia, Washington, Forente stater, 98531
        • Providence Regional Cancer System-Centralia
      • Edmonds, Washington, Forente stater, 98026
        • Swedish Cancer Institute-Edmonds
      • Enumclaw, Washington, Forente stater, 98022
        • Saint Elizabeth Hospital
      • Everett, Washington, Forente stater, 98201
        • Providence Regional Cancer Partnership
      • Federal Way, Washington, Forente stater, 98003
        • Saint Francis Hospital
      • Issaquah, Washington, Forente stater, 98029
        • Swedish Cancer Institute-Issaquah
      • Kennewick, Washington, Forente stater, 99336
        • Kadlec Clinic Hematology and Oncology
      • Kirkland, Washington, Forente stater, 98034
        • Seattle Cancer Care Alliance at EvergreenHealth
      • Kirkland, Washington, Forente stater, 98033
        • EvergreenHealth Medical Center
      • Lacey, Washington, Forente stater, 98503
        • Providence Regional Cancer System-Lacey
      • Lakewood, Washington, Forente stater, 98499
        • Saint Clare Hospital
      • Mount Vernon, Washington, Forente stater, 98274
        • Skagit Valley Hospital
      • Olympia, Washington, Forente stater, 98506-5166
        • Providence - Saint Peter Hospital
      • Olympia, Washington, Forente stater, 98507
        • Capital Medical Center
      • Poulsbo, Washington, Forente stater, 98370
        • Harrison HealthPartners Hematology and Oncology-Poulsbo
      • Puyallup, Washington, Forente stater, 98372
        • MultiCare Good Samaritan Hospital
      • Seattle, Washington, Forente stater, 98109
        • Fred Hutchinson Cancer Research Center
      • Seattle, Washington, Forente stater, 98104
        • Harborview Medical Center
      • Seattle, Washington, Forente stater, 98101
        • Virginia Mason Medical Center
      • Seattle, Washington, Forente stater, 98107
        • Swedish Medical Center-Ballard Campus
      • Seattle, Washington, Forente stater, 98195
        • University of Washington Medical Center - Montlake
      • Seattle, Washington, Forente stater, 98112
        • Kaiser Permanente Washington
      • Seattle, Washington, Forente stater, 98104
        • Minor and James Medical PLLC
      • Seattle, Washington, Forente stater, 98122-4307
        • Swedish Medical Center-First Hill
      • Seattle, Washington, Forente stater, 98104
        • Pacific Medical Center-First Hill
      • Sedro-Woolley, Washington, Forente stater, 98284
        • PeaceHealth United General Medical Center
      • Spokane, Washington, Forente stater, 99218
        • Evergreen Hematology and Oncology PS
      • Spokane, Washington, Forente stater, 99202
        • Cancer Care Northwest - Spokane South
      • Spokane, Washington, Forente stater, 99220
        • Rockwood Clinic
      • Tacoma, Washington, Forente stater, 98405
        • Northwest Medical Specialties PLLC
      • Tacoma, Washington, Forente stater, 98431
        • Madigan Army Medical Center
      • Tacoma, Washington, Forente stater, 98405
        • MultiCare Tacoma General Hospital
      • Tacoma, Washington, Forente stater, 98405
        • Franciscan Research Center-Northwest Medical Plaza
      • Tacoma, Washington, Forente stater, 98405
        • MultiCare Allenmore Hospital
      • Tacoma, Washington, Forente stater, 98405
        • Northwest NCI Community Oncology Research Program
      • Tacoma, Washington, Forente stater, 98405
        • Saint Joseph Medical Center
      • Wenatchee, Washington, Forente stater, 98801
        • Wenatchee Valley Hospital and Clinics
    • West Virginia
      • Charleston, West Virginia, Forente stater, 25304
        • West Virginia University Charleston Division
      • Huntington, West Virginia, Forente stater, 25701
        • Edwards Comprehensive Cancer Center
      • Morgantown, West Virginia, Forente stater, 26506
        • West Virginia University Healthcare
    • Wisconsin
      • Antigo, Wisconsin, Forente stater, 54409
        • Langlade Hospital and Cancer Center
      • Burlington, Wisconsin, Forente stater, 53105
        • Aurora Cancer Care-Southern Lakes VLCC
      • Chippewa Falls, Wisconsin, Forente stater, 54729
        • Marshfield Clinic-Chippewa Center
      • Eau Claire, Wisconsin, Forente stater, 54701
        • Marshfield Clinic Cancer Center at Sacred Heart
      • Germantown, Wisconsin, Forente stater, 53022
        • Aurora Health Care Germantown Health Center
      • Grafton, Wisconsin, Forente stater, 53024
        • Aurora Cancer Care-Grafton
      • Green Bay, Wisconsin, Forente stater, 54311
        • Aurora BayCare Medical Center
      • Green Bay, Wisconsin, Forente stater, 54301
        • Saint Vincent Hospital Cancer Center Green Bay
      • Green Bay, Wisconsin, Forente stater, 54303
        • Saint Vincent Hospital Cancer Center at Saint Mary's
      • Green Bay, Wisconsin, Forente stater, 54303
        • Green Bay Oncology Limited at Saint Mary's Hospital
      • Green Bay, Wisconsin, Forente stater, 54301-3526
        • Green Bay Oncology at Saint Vincent Hospital
      • Johnson Creek, Wisconsin, Forente stater, 53038
        • UW Cancer Center Johnson Creek
      • Kenosha, Wisconsin, Forente stater, 53142
        • Aurora Cancer Care-Kenosha South
      • La Crosse, Wisconsin, Forente stater, 54601
        • Gundersen Lutheran Medical Center
      • Madison, Wisconsin, Forente stater, 53792
        • University of Wisconsin Carbone Cancer Center
      • Manitowoc, Wisconsin, Forente stater, 54221
        • Holy Family Memorial Hospital
      • Marinette, Wisconsin, Forente stater, 54143
        • Aurora Bay Area Medical Group-Marinette
      • Marinette, Wisconsin, Forente stater, 54143
        • Bay Area Medical Center
      • Marshfield, Wisconsin, Forente stater, 54449
        • Marshfield Medical Center-Marshfield
      • Milwaukee, Wisconsin, Forente stater, 53226
        • Medical College of Wisconsin
      • Milwaukee, Wisconsin, Forente stater, 53209
        • Aurora Cancer Care-Milwaukee
      • Milwaukee, Wisconsin, Forente stater, 53215
        • Aurora Saint Luke's Medical Center
      • Milwaukee, Wisconsin, Forente stater, 53233
        • Aurora Sinai Medical Center
      • Minocqua, Wisconsin, Forente stater, 54548
        • Marshfield Clinic-Minocqua Center
      • New Richmond, Wisconsin, Forente stater, 54017
        • Cancer Center of Western Wisconsin
      • Oconto Falls, Wisconsin, Forente stater, 54154
        • Saint Vincent Hospital Cancer Center at Oconto Falls
      • Oshkosh, Wisconsin, Forente stater, 54904
        • Vince Lombardi Cancer Clinic - Oshkosh
      • Racine, Wisconsin, Forente stater, 53406
        • Aurora Cancer Care-Racine
      • Rhinelander, Wisconsin, Forente stater, 54501
        • Ascension Saint Mary's Hospital
      • Rice Lake, Wisconsin, Forente stater, 54868
        • Marshfield Medical Center-Rice Lake
      • Sheboygan, Wisconsin, Forente stater, 53081
        • Vince Lombardi Cancer Clinic-Sheboygan
      • Sheboygan, Wisconsin, Forente stater, 53081
        • HSHS Saint Nicholas Hospital
      • Stevens Point, Wisconsin, Forente stater, 54481
        • Ascension Saint Michael's Hospital
      • Sturgeon Bay, Wisconsin, Forente stater, 54235-1495
        • Saint Vincent Hospital Cancer Center at Sturgeon Bay
      • Sturgeon Bay, Wisconsin, Forente stater, 54235
        • Green Bay Oncology - Sturgeon Bay
      • Summit, Wisconsin, Forente stater, 53066
        • Aurora Medical Center in Summit
      • Two Rivers, Wisconsin, Forente stater, 54241
        • Vince Lombardi Cancer Clinic-Two Rivers
      • Waukesha, Wisconsin, Forente stater, 53188
        • Aurora Cancer Care-Waukesha
      • Wausau, Wisconsin, Forente stater, 54401
        • Aspirus Regional Cancer Center
      • Wausau, Wisconsin, Forente stater, 54401
        • Marshfield Clinic-Wausau Center
      • Wauwatosa, Wisconsin, Forente stater, 53226
        • Aurora Cancer Care-Milwaukee West
      • West Allis, Wisconsin, Forente stater, 53227
        • Aurora West Allis Medical Center
      • Weston, Wisconsin, Forente stater, 54476
        • Marshfield Medical Center - Weston
      • Wisconsin Rapids, Wisconsin, Forente stater, 54494
        • Marshfield Clinic - Wisconsin Rapids Center
    • Wyoming
      • Casper, Wyoming, Forente stater, 82609
        • Rocky Mountain Oncology
      • Cheyenne, Wyoming, Forente stater, 82001
        • Cheyenne Regional Medical Center-West
      • Sheridan, Wyoming, Forente stater, 82801
        • Welch Cancer Center
      • San Juan, Puerto Rico, 00936
        • San Juan City Hospital

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

16 år og eldre (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Beskrivelse

Inklusjonskriterier:

  • Pasienter må ha histologisk eller cytologisk dokumentert metastatisk eller ikke-opererbart overgangscellekarsinom (urotelialt) i urinveiene (nyrebekken, urinleder, blære, prostata eller urinrør), med metastatisk eller lokalt avansert sykdom (T4b, N2, N3 eller M1) ; Pasienter må ikke være kandidater for potensielt kurativ kirurgi eller strålebehandling

    • For pasienter som har hatt kirurgisk reseksjon før studieregistrering, må gjenværende eller ureseksjonert sykdom (målbar og/eller ikke-målbar) være tydelig på post-kirurgiske skanninger
  • Tidligere behandling for overgangscellekarsinom (TCC)

    • Pasienter kan ikke ha mottatt systemisk kombinasjonskjemoterapi for metastatisk sykdom
    • For formålet med denne studien regnes ikke radiosensibiliserende kjemoterapi med enkeltmiddel som tidligere systemisk terapi
    • Tidligere neoadjuvant eller adjuvant systemisk kjemoterapi er tillatt forutsatt at intervallet fra avsluttet behandling til diagnose av metastatisk sykdom er minst 1 år
    • >= 4 uker siden noen tidligere stråling (inkludert palliativ) eller større operasjon og fullstendig restituert
    • >= 7 dager siden en mindre operasjon som portplassering
    • >= 4 uker siden noen intravesikal behandling
    • Ingen tidligere behandling med bevacizumab eller andre angiogenesehemmere
  • Ingen kjent historie med hjernemetastaser; hjerneavbildning (magnetisk resonansavbildning [MRI]/computertomografi [CT]) er ikke nødvendig
  • Ingen nåværende kongestiv hjertesvikt; New York Heart Association (NYHA) klasse II, III eller IV
  • Pasienter med hypertensjon i anamnesen må være godt kontrollert (< 150/90) på et regime med antihypertensiv terapi
  • Pasienter på fulldose antikoagulantia må ha en stabil dose warfarin og ha et internasjonalt normalisert forhold (INR) (vanligvis mellom 2 og 3) eller være på en stabil dose lavmolekylært heparin (LMW); pasienter som får anti-blodplatemidler er også kvalifisert; i tillegg er pasienter som bruker daglig profylaktisk aspirin eller antikoagulasjon for atrieflimmer kvalifisert
  • Ingen signifikant historie med blødningshendelser eller gastrointestinal (GI) perforering

    • Pasienter med en historie med en betydelig blødningsepisode (f. hemoptyse, øvre eller nedre GI-blødning, grad 3 eller 4 grov hematuri som ikke kan kontrolleres ved transuretral reseksjon av blæretumor) innen 6 måneder etter registrering er ikke kvalifisert
    • Pasienter med en historie med GI-perforasjon innen 12 måneder etter registrering er ikke kvalifisert
    • Pasienter med en historie med peritoneal karsinomatose er ikke kvalifisert
  • Ingen arterielle trombotiske hendelser innen 6 måneder etter registrering, inkludert forbigående iskemisk angrep (TIA), cerebrovaskulær ulykke (CVA), perifer arteriell trombe, ustabil angina eller angina som krever kirurgisk eller medisinsk intervensjon de siste 6 månedene, eller hjerteinfarkt (MI); pasienter med klinisk signifikant perifer arteriesykdom (dvs. claudicatio på mindre enn én blokk) er ikke kvalifiserte
  • Pasienter som har opplevd dyp venetrombose eller lungeemboli i løpet av de siste 6 månedene må ha stabil terapeutisk antikoagulasjon for å bli registrert i denne studien
  • Ingen alvorlige eller ikke-helende sår, sår eller benbrudd
  • Ingen sensorisk eller motorisk perifer nevropati >= grad 2
  • Pasienter med kjent overfølsomhet overfor eggstokkcelleprodukter fra kinesisk hamster eller andre rekombinante humane antistoffer er ikke kvalifisert
  • Pasienter som er gravide eller ammer er ikke kvalifisert; kvinner i fertil alder må ha en negativ serum- eller uringraviditetstest (minimum følsomhet 25 IE/L eller tilsvarende enheter humant koriongonadotropin [HCG]) innen 72 timer før registrering

    • For kvinner i fertil alder med forhøyet beta-HCG som antas å være relatert til kreft og ikke graviditet, kreves en negativ transvaginal ultralyd og gynekologisk undersøkelse
    • Kvinner i fertil alder inkluderer alle kvinner som har opplevd menarke og som ikke har gjennomgått kirurgisk sterilisering (hysterektomi, bilateral tubal ligering eller bilateral ooforektomi) eller ikke er postmenopausal [definert som amenoré >= 12 påfølgende måneder; eller kvinner på hormonerstatningsterapi [HRT] med dokumentert serumfollikkelstimulerende hormon [FSH] nivå > 35 mIU/ml); til og med kvinner som bruker orale, implanterte eller injiserbare prevensjonshormoner eller mekaniske produkter som intrauterin enhet eller barrieremetoder (diafragma, kondomer, sæddrepende midler) for å forhindre graviditet eller praktisere avholdenhet eller hvor partneren er steril (f.eks. vasektomi), bør vurderes å være i fertil alder
  • Eastern Cooperative Oncology Group (ECOG) ytelsesstatus 0-1 (eller Karnofsky ytelsesstatus [KPS] >= 80)
  • Absolutt nøytrofiltall (ANC) >= 1500/uL
  • Blodplateantall >= 100 000/uL
  • Beregnet eller målt kreatininclearance >= 50 ml/minutt
  • Bilirubin =< 1,25 ganger øvre normalgrense; for pasienter med Gilberts sykdom er =< 2,5 x øvre normalgrense (ULN) tillatt
  • Aspartataminotransferase (AST) =< 2,0 x øvre normalgrense
  • Urinprotein til kreatininforhold < 1,0 eller urinprotein =< 1+ eller 24-timers urinprotein =< 1 gram

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Behandling
  • Tildeling: Randomisert
  • Intervensjonsmodell: Parallell tildeling
  • Masking: Dobbelt

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Aktiv komparator: Arm I (gemcitabinhydroklorid, cisplatin, placebo)
Pasienter får gemcitabinhydroklorid IV over 30 minutter på dag 1 og 8 og cisplatin IV og placebo IV over 30-90 minutter på dag 1. Behandlingen gjentas hver 21. dag i 6 sykluser i fravær av sykdomsprogresjon eller uakseptabel toksisitet. Pasienter får deretter placebo IV over 30-90 minutter hver 21. dag i fravær av sykdomsprogresjon eller uakseptabel toksisitet.
Korrelative studier
Gitt IV
Andre navn:
  • CDDP
  • Cis-diammindikloridplatina
  • Cismaplat
  • Cisplatinum
  • Neoplatin
  • Platinol
  • Abiplatin
  • Blastolem
  • Briplatin
  • Cis-diammin-diklorplatina
  • Cis-diamindiklor platina (II)
  • Cis-diamindiklorplatina
  • Cis-dikloramin platina (II)
  • Cis-platinøs diamin diklorid
  • Cis-platina
  • Cis-platina II
  • Cis-platina II diamin diklorid
  • Cisplatina
  • Cisplatyl
  • Citoplatino
  • Citosin
  • Cysplatyna
  • DDP
  • Lederplatin
  • Metaplatin
  • Peyrones klorid
  • Peyrones salt
  • Placis
  • Plastistil
  • Platamin
  • Platiblastin
  • Platiblastin-S
  • Platinex
  • Platinol-AQ
  • Platinol-AQ VHA Plus
  • Platinoxan
  • Platina
  • Platina diaminodiklorid
  • Platiran
  • Platistin
  • Platosin
Gitt IV
Andre navn:
  • Gemzar
  • dFdCyd
  • Difluordeoksycytidinhydroklorid
  • FF 10832
  • FF-10832
  • FF10832
  • Gemcitabin HCI
  • LY-188011
  • LY188011
Gitt IV
Eksperimentell: Arm II (gemcitabinhydroklorid, cisplatin, bevacizumab)
Pasienter får gemcitabinhydroklorid og cisplatin som i arm I. Pasienter får også bevacizumab IV over 30-90 minutter på dag 1. Behandlingen gjentas hver 21. dag i 6 sykluser i fravær av sykdomsprogresjon eller uakseptabel toksisitet. Pasienter får deretter bevacizumab IV over 30-90 minutter hver 21. dag i fravær av sykdomsprogresjon eller uakseptabel toksisitet.
Korrelative studier
Gitt IV
Andre navn:
  • CDDP
  • Cis-diammindikloridplatina
  • Cismaplat
  • Cisplatinum
  • Neoplatin
  • Platinol
  • Abiplatin
  • Blastolem
  • Briplatin
  • Cis-diammin-diklorplatina
  • Cis-diamindiklor platina (II)
  • Cis-diamindiklorplatina
  • Cis-dikloramin platina (II)
  • Cis-platinøs diamin diklorid
  • Cis-platina
  • Cis-platina II
  • Cis-platina II diamin diklorid
  • Cisplatina
  • Cisplatyl
  • Citoplatino
  • Citosin
  • Cysplatyna
  • DDP
  • Lederplatin
  • Metaplatin
  • Peyrones klorid
  • Peyrones salt
  • Placis
  • Plastistil
  • Platamin
  • Platiblastin
  • Platiblastin-S
  • Platinex
  • Platinol-AQ
  • Platinol-AQ VHA Plus
  • Platinoxan
  • Platina
  • Platina diaminodiklorid
  • Platiran
  • Platistin
  • Platosin
Gitt IV
Andre navn:
  • Gemzar
  • dFdCyd
  • Difluordeoksycytidinhydroklorid
  • FF 10832
  • FF-10832
  • FF10832
  • Gemcitabin HCI
  • LY-188011
  • LY188011
Gitt IV
Andre navn:
  • Avastin
  • ABP 215
  • Anti-VEGF
  • Anti-VEGF humanisert monoklonalt antistoff
  • Anti-VEGF monoklonalt antistoff SIBP04
  • Anti-VEGF rhuMAb
  • Bevacizumab awwb
  • Bevacizumab Biosimilar ABP 215
  • Bevacizumab Biosimilar BEVZ92
  • Bevacizumab Biosimilar BI 695502
  • Bevacizumab Biosimilar CBT 124
  • Bevacizumab Biosimilar CT-P16
  • Bevacizumab Biosimilar FKB238
  • Bevacizumab Biosimilar GB-222
  • Bevacizumab Biosimilar HD204
  • Bevacizumab Biosimilar HLX04
  • Bevacizumab Biosimilar IBI305
  • Bevacizumab Biosimilar LY01008
  • Bevacizumab Biosimilar MIL60
  • Bevacizumab Biosimilar Mvasi
  • Bevacizumab Biosimilar MYL-1402O
  • Bevacizumab Biosimilar QL 1101
  • Bevacizumab Biosimilar RPH-001
  • Bevacizumab Biosimilar SCT501
  • Bevacizumab Biosimilar Zirabev
  • Bevacizumab-awwb
  • Bevacizumab-bvzr
  • BP102
  • BP102 Biosimilar
  • HD204
  • Immunoglobulin G1 (Human-mus monoklonal rhuMab-VEGF Gamma-kjede anti-human vaskulær endotelial vekstfaktor), disulfid med human-mus monoklonal rhuMab-VEGF lett kjede, dimer
  • Mvasi
  • MYL-1402O
  • Rekombinant humanisert anti-VEGF monoklonalt antistoff
  • rhuMab-VEGF
  • SCT501
  • SIBP 04
  • SIBP-04
  • SIBP04
  • Zirabev

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Total overlevelse (OS)
Tidsramme: Fra dato for randomisering til dato for død på grunn av en hvilken som helst årsak, vurdert opp til 7 år
Samlet overlevelsestid er definert som tiden fra randomisering til død på grunn av en hvilken som helst årsak. Median- og 95 % konfidensintervall er estimert ved å bruke Kaplan-Meier-estimatoren. Den stratifiserte log-rank-statistikken vil være den primære analysen for å sammenligne de to behandlingsarmene på OS med stratifiseringsfaktorene: tilstedeværelse av viscerale metastaser (nei, ja) og tidligere kjemoterapi (nei, ja). I tillegg vil den proporsjonale faremodellen bli brukt for å vurdere viktigheten av at behandlingsarmen justerer på pasientkarakteristikker, stratifiseringsvariabler og andre viktige kovariater for å forutsi OS.
Fra dato for randomisering til dato for død på grunn av en hvilken som helst årsak, vurdert opp til 7 år

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Progresjonsfri overlevelse (PFS)
Tidsramme: Fra datoen for randomisering til datoen for progresjon eller død på grunn av en hvilken som helst årsak, avhengig av hva som inntreffer først, vurdert opp til 7 år
Den primære analysen av PFS vil være en tosidig stratifisert log-rank test som sammenligner arm A og arm B. Stratifiseringsfaktorene vil bestå av de to stratifiseringsfaktorene som brukes for pasientrandomisering: tidligere nefrektomi (ja vs. nei) og Motzer score ( 0 vs. 1-2 vs. 3+). Resultater fra ustratifiserte log-rank tester vil også bli gitt. Kaplan-Meier metodikk vil bli brukt for å estimere median PFS for hver behandlingsarm.
Fra datoen for randomisering til datoen for progresjon eller død på grunn av en hvilken som helst årsak, avhengig av hva som inntreffer først, vurdert opp til 7 år
Objektiv respons
Tidsramme: Inntil 7 år

Objektiv respons er definert som bekreftede komplette og delvise responser ved bruk av responsevalueringskriterier i solide svulster. En fullstendig respons (CR) er definert som en forsvinning av alle mållesjoner. En partiell respons (PR) er definert som å ha minst 30 % reduksjon i summen av den lengste diameteren til mållesjonene med utgangspunkt i summen.

I hver arm ble antallet pasienter som rapporterte en CR eller PR delt på antall pasienter som kunne evalueres i hver arm for å få andelen.

Inntil 7 år
Antall pasienter som opplever grad 3+ toksisitet
Tidsramme: Inntil 7 år
Antall pasienter som opplever grad 3 eller høyere toksisitet (bivirkninger som i det minste anses som mulig relatert til behandling) er rapportert nedenfor.
Inntil 7 år

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Etterforskere

  • Hovedetterforsker: Jonathan E Rosenberg, Alliance for Clinical Trials in Oncology

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

15. juli 2009

Primær fullføring (Faktiske)

2. november 2018

Studiet fullført (Faktiske)

15. juni 2021

Datoer for studieregistrering

Først innsendt

17. juli 2009

Først innsendt som oppfylte QC-kriteriene

17. juli 2009

Først lagt ut (Antatt)

20. juli 2009

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

16. oktober 2023

Siste oppdatering sendt inn som oppfylte QC-kriteriene

12. oktober 2023

Sist bekreftet

1. oktober 2023

Mer informasjon

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

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