- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01201330
DPBRN Retrospective Cohort Study of Osteonecrosis of the Jaw
June 14, 2011 updated by: Dental Practice-Based Research Network
Retrospective Cohort Study of ONJ
The purpose of this study was to determine the prevalence of ONJ in the patient population of 2 large HMOs and study the risk factors associated with the development of this condition.
Study Overview
Status
Completed
Conditions
Detailed Description
The electronic database from Kaiser Permanente and HealthParnters of Minnesota were used to identify all ONJ cases that occured between 1994 and 2006 and then demographic, social and medical risk factors possibly associated with the disease were abstracted and analyzed.
Study Type
Observational
Enrollment (Actual)
572606
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Alabama
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Birmingham, Alabama, United States, 35294-0007
- Gregg H. Gilbert, DDS, MBA
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
41 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
All patients older than 40 with a history of jaw osteonecrosis and control patients with exposure to biphosphonates were included.
Description
Inclusion Criteria:
- ONJ sufferers and control biphosphonate users older than 40, of any gender, race and ethnic origin
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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ONJ sufferers
history of jaw osteonecrosis
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Bisphosphonate exposure
patients with exposure to bisphosphonates
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Investigators
- Principal Investigator: Jeffrey Fellows, Ph.D., Kaiser Permanente
- Principal Investigator: Andrei Barasch, DMD,MDSc, University of Alabama at Birmingham
- Principal Investigator: Brad Rindal, DMD, HealthPartners of Minnesota
- Study Chair: Gregg H Gilbert, DDS, MBA, University of Alabama School of Dentistry
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2007
Primary Completion (Actual)
May 1, 2008
Study Completion (Actual)
May 1, 2008
Study Registration Dates
First Submitted
September 13, 2010
First Submitted That Met QC Criteria
September 13, 2010
First Posted (Estimate)
September 14, 2010
Study Record Updates
Last Update Posted (Estimate)
June 16, 2011
Last Update Submitted That Met QC Criteria
June 14, 2011
Last Verified
June 1, 2011
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 106030
- U01DE016747 (U.S. NIH Grant/Contract)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Osteonecrosis of the Jaw
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Fundació d'investigació Sanitària de les Illes...RecruitingOsteonecrosis of the Jaw, Bisphosphonate Induced | Osteonecrosis of the Jaw, Bisphosphonate RelatedSpain
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University of WashingtonUniversity of Alabama at Birmingham; University of Michigan; New York Center...Enrolling by invitationAvascular Necrosis | Medication-related Osteonecrosis of the Jaw | Bisphosphonate-related Osteonecrosis of the JawUnited States
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AO Clinical Investigation and Publishing DocumentationAOCMFActive, not recruitingBisphosphonate-Associated Osteonecrosis of the Jaw | Medication-related Osteonecrosis of the JawGermany, Qatar, Switzerland, Finland, United States, Slovenia, Spain, Netherlands, Romania, Korea, Republic of
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Micromedic Technologies LtdUnknownBisphosphonate-related Osteonecrosis of the JawIsrael
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University of Southern CaliforniaNational Cancer Institute (NCI)WithdrawnMalignant Neoplasm | Musculoskeletal ComplicationsUnited States
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AmgenCompletedOsteonecrosis of the JawFrance, Germany, Italy, United States, Belgium, United Kingdom, Spain, Greece, Canada, Denmark, Finland
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Medical University of GrazEnrolling by invitation
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Dental Practice-Based Research NetworkNational Institute of Dental and Craniofacial Research (NIDCR); HealthPartners... and other collaboratorsCompleted
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University of PalermoCompletedMEDICATION RELATED OSTEONECROSIS OF THE JAWItaly
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University of PalermoSuspendedMEDICATION RELATED OSTEONECROSIS OF THE JAWItaly