Resistance Exercise in Healthy Men

October 25, 2013 updated by: Lex Verdijk, Maastricht University Medical Center

The Effect of Age and Dietary Protein Intake on Myocellular Characteristics Following a Single Bout of Resistance Exercise in Healthy Men

In the present study, the effects of age and dietary intake will be assessed on myocellular characteristics during 72 hours after a resistance type exercise session.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

34

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Netherlands
    • Zuid Limburg
      • Maastricht, Zuid Limburg, Netherlands, 6200MD
        • Maastricht University Medical Centre

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 85 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • healthy men between the ages of 18-30 or 70-85 years

Exclusion Criteria:

  • Subjects with a recent history or current state of cardiovascular disease, COPD, Parkinson, rheumatoid arthritis, musculoskeletal/orthopaedic disorders, renal disorder, cognitive impairment.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Young regular diet
During the time of the study this group will adhere to a standardized regular diet.
Behavioral: Adhere to a specific standardized diet for 4 days
24 h before the start of the intervention all subjects will adhere to a standardized diet for 4 days. Young subjects are randomly allocated to either a low protein diet, regular protein diet or high protein diet group. All elderly subjects will adhere to a regular protein diet comparable to the regular protein diet of the young subjects.
Experimental: Young low protein diet
During the time of the study this group will adhere to a standardized low protein diet.
Behavioral: Adhere to a specific standardized diet for 4 days
24 h before the start of the intervention all subjects will adhere to a standardized diet for 4 days. Young subjects are randomly allocated to either a low protein diet, regular protein diet or high protein diet group. All elderly subjects will adhere to a regular protein diet comparable to the regular protein diet of the young subjects.
Experimental: Young high protein
During the time of the study this group will adhere to a standardized high protein diet.
Behavioral: Adhere to a specific standardized diet for 4 days
24 h before the start of the intervention all subjects will adhere to a standardized diet for 4 days. Young subjects are randomly allocated to either a low protein diet, regular protein diet or high protein diet group. All elderly subjects will adhere to a regular protein diet comparable to the regular protein diet of the young subjects.
Experimental: Elderly
During the time of the study this group will adhere to a standardized high protein diet
Behavioral: Adhere to a specific standardized diet for 4 days
24 h before the start of the intervention all subjects will adhere to a standardized diet for 4 days. Young subjects are randomly allocated to either a low protein diet, regular protein diet or high protein diet group. All elderly subjects will adhere to a regular protein diet comparable to the regular protein diet of the young subjects.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Muscle fiber myonuclear and stem cell content
Time Frame: baseline
baseline
Muscle fiber myonuclear and stem cell content
Time Frame: 12 hours after a single bout of resistance type exercise
12 hours after a single bout of resistance type exercise
Muscle fiber myonuclear and stem cell content
Time Frame: 24 hours after a single bout of resistance type exercise
24 hours after a single bout of resistance type exercise
Muscle fiber myonuclear and stem cell content
Time Frame: 48 hours after a single bout of resistance type exercise
48 hours after a single bout of resistance type exercise
Muscle fiber myonuclear and stem cell content
Time Frame: 72 hours after a single bout resistance type exercise
72 hours after a single bout resistance type exercise

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Maastricht University Medical Center

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

April 1, 2010

Primary Completion (Actual)

September 1, 2011

Study Completion (Actual)

December 1, 2011

Study Registration Dates

First Submitted

October 7, 2010

First Submitted That Met QC Criteria

October 12, 2010

First Posted (Estimate)

October 13, 2010

Study Record Updates

Last Update Posted (Estimate)

October 28, 2013

Last Update Submitted That Met QC Criteria

October 25, 2013

Last Verified

October 1, 2013

More Information

Terms related to this study

Other Study ID Numbers

  • MEC 09-3-080

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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