Effect of Low Glycemic Index Diet on Body Composition and Mechanism of Obese Women

Effect of Low Glycemic Index Diet on Body Composition and Mechanism of Obese

Excessive body weight and obesity have reached epidemic proportions over the last few decades, which may cause many chronic diseases. Maintaining a healthy life style could decrease the risk for obesity, metabolic syndrome and cardiovascular disease. The study aimed to evaluate long-term low glycemic index (GI) diet intervention on lipid profile, body composition and the mechanism of obese women. The pilot study will recruit twenty healthy subjects, and served test food to determine low GI food. In the experiment period, twenty women age from 20-50 years will be recruited. To be included in the study, subjects should have a BMI above 24 kg/m2, or the either one (fat mass ≧ 30% or waistline > 80 cm). Before dietary intervention, participants will receive food choice table and dietary questionnaires to record their dietary intake.

The study will be a randomized, crossover, controlled clinical trails. The experiment period have six weeks, each participants will provide low GI diet (lunch and dinner). On the 0, 3, 6 week, subjects will measurement their body composition (body weight, body mass, waist and hip circumferences) and collect fasting blood samples to analysis the lipid profile, free fatty acid, blood sugar, insulin, adiponectin, leptin and fatty acid synthesis enzymes. Statistical analysis will be performed by paired t-test. The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women.

Study Overview

• Status: Unknown
• Conditions: Obesity
• Intervention / Treatment: Other: Low glycemic index diet

• Study Type: Interventional
• Enrollment (Anticipated): 20
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Taipei, Taiwan
    • Taipei Medical University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 50 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• BMI above 24 kg/m2, or the either one ( fat mass ≧ 30% or waistline > 80 cm )

Exclusion Criteria:

• Cardiovascular disease
• type 2 diabetes mellitus or impaired glucose tolerance
• serious liver or renal disease, gastro-intestinal disease
• proceed serious diet control for formerly three months
• take any supplemental food products or medications known to influence lipid or carbohydrate metabolism

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Health Services Research
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Low glycemic index diet; The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women	Other: Low glycemic index diet; The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women
Experimental: diet intervention; The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women	Other: Low glycemic index diet; The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
the effect of body composition ( body weight,body mass,waist and hip circumferences )	6 week

Collaborators and Investigators

• Sponsor: Taipei Medical University WanFang Hospital
• Investigators: Principal Investigator: Jen-Fang Liu, Taipei Medical University

Study record dates

Study Major Dates

• Study Start: May 1, 2010
• Primary Completion (Anticipated): February 1, 2011
• Study Completion (Anticipated): April 1, 2011

Study Registration Dates

• First Submitted: November 18, 2010
• First Submitted That Met QC Criteria: December 5, 2010
• First Posted (Estimate): December 7, 2010

Study Record Updates

• Last Update Posted (Estimate): December 7, 2010
• Last Update Submitted That Met QC Criteria: December 5, 2010
• Last Verified: December 1, 2010

More Information

Terms related to this study

• Keywords: obesity; body composition; adipocyte-derived cytokine; low glycemic index
• Additional Relevant MeSH Terms: Overnutrition; Nutrition Disorders; Overweight; Body Weight; Obesity
• Other Study ID Numbers: 99055