Docetaxel and Cyclophosphamide Compared to Anthracycline-Based Chemotherapy in Treating Women With HER2-Negative Breast Cancer
April 13, 2022 updated by: NSABP Foundation Inc
A Phase III Clinical Trial Comparing the Combination of Docetaxel Plus Cyclophosphamide to Anthracycline-Based Chemotherapy Regimens for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of breast cancer cells, either by killing the cells or by stopping them from dividing. Giving the drugs in different combinations may kill more breast cancer cells. Giving combination chemotherapy after surgery may kill any tumor cells that remain after surgery.
PURPOSE: This randomized phase III trial is studying different combination chemotherapy regimens and their side effects and comparing how well they work in treating women with non-metastatic breast cancer.
Study Overview
Status
Active, not recruiting
Conditions
Intervention / Treatment
Detailed Description
OBJECTIVES:
Primary
- To determine if the docetaxel and cyclophosphamide (TC) regimen is non-inferior to the anthracycline-based chemotherapy regimens in terms of invasive disease-free survival (DFS) by combining B-49 data with the docetaxel, doxorubicin, and cyclophosphamide (TAC) and TC arms of NSABP B-46-I/US Oncology Research, Inc.(USOR) 07132 and the data from USOR 06-090.
Secondary
- To determine rates of DFS-ductal carcinoma in situ (DCIS) for the TC and anthracycline-based chemotherapy regimens.
- To determine rates of overall survival (OS) for the TC and anthracycline-based chemotherapy regimens.
- To determine rates of recurrence-free interval (RFI) for the TC and anthracycline-based chemotherapy regimens.
- To evaluate the toxicity associated with each of the regimens.
- To determine the role of TOP2A in prognosis and prediction of degree of benefit from anthracycline-based chemotherapy over TC. (exploratory)
- To develop predictive markers for benefit from doxorubicin. (exploratory)
OUTLINE: This is a multicenter randomized study. Patients are stratified according to number of positive nodes (0 vs 1-3 vs 4-9 vs 10+) and hormone-receptor status (estrogen receptor [ER] and/or progesterone receptor [PgR] positive vs ER and PgR negative). Patients are randomized to 1 of 2 treatment arms.
Study Type
Interventional
Enrollment (Actual)
1871
Phase
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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San Juan, Puerto Rico, 00936
- San Juan City Hospital
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Alaska
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Anchorage, Alaska, United States, 99508
- Providence Alaska Medical Center
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Arizona
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Phoenix, Arizona, United States, 85016
- Arizona Oncology Associates-Biltmore Cancer Center
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Scottsdale, Arizona, United States, 85258
- Premiere Oncology of Arizona
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Sedona, Arizona, United States, 86336
- Sedona Medical Center
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Tucson, Arizona, United States, 85704
- Arizona Oncology Associates
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Arkansas
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Jonesboro, Arkansas, United States, 72401
- NEA Baptist Clinic-Matthews
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California
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Anaheim, California, United States, 92807
- Kaiser Anaheim Medical Center
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Antioch, California, United States, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Baldwin Park, California, United States, 91706
- Kaiser Permanente Medical Group - Baldwin Park
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Bellflower, California, United States, 90706
- Kaiser Foundation Hospital
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Burbank, California, United States, 91505
- Providence Saint Joseph Medical Center
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Castro Valley, California, United States, 94546
- East Bay Radiation Oncology Center
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Castro Valley, California, United States, 94546
- Valley Medical Oncology Consultants-Castro Valley
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Dublin, California, United States, 94568
- Epic Care-Dublin
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Fairfield, California, United States, 94533
- Northbay Cancer Center
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Fontana, California, United States, 92335
- Kaiser Permanente Hospital
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Fremont, California, United States, 94538
- Valley Medical Oncology Consultants-Fremont
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Fremont, California, United States, 94538
- Washington Hospital
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Fremont, California, United States, 94538
- Kaiser Permanente, Fremont
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Fresno, California, United States, 93720
- Kaiser Permanente
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Fresno, California, United States, 93720
- California Cancer Center - North Fresno
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Harbor City, California, United States, 90710
- Kaiser Permanente - Harbor City
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Hayward, California, United States, 94545
- Kaiser Permanente, Hayward
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Irvine, California, United States, 92618
- Southern California Permanente Medical Group
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La Jolla, California, United States, 92093
- UC San Diego Moores Cancer Center
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Long Beach, California, United States, 90806
- Long Beach Memorial Medical Center-Todd Cancer Institute
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Los Angeles, California, United States, 90048
- Cedars-Sinai Medical Center
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Los Angeles, California, United States, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, United States, 90027
- Kaiser Permanente
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Los Angeles, California, United States, 90034
- Kaiser Permanente-West Los Angeles
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Martinez, California, United States, 94553-3156
- Contra Costa Regional Medical Center
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Modesto, California, United States, 95355
- Memorial Medical Center
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Modesto, California, United States, 95356
- Kaiser Permanente-Modesto
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Monterey, California, United States, 93940
- Community Hospital of Monterey Peninsula
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Mountain View, California, United States, 94040
- El Camino Hospital
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Oakland, California, United States, 94611
- Kaiser Permanente-Oakland
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Oakland, California, United States, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, United States, 94602
- Highland General Hospital
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Oakland, California, United States, 94609
- Bay Area Breast Surgeons Inc
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Oakland, California, United States, 94609
- Larry G Strieff MD Medical Corporation
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Oakland, California, United States, 94609
- Tom K Lee Inc
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Oakland, California, United States, 94609
- Bay Area Tumor Institute
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Oakland, California, United States, 94612
- Epic Care-Oakland
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Palm Springs, California, United States, 92262
- Desert Regional Medical Center
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Panorama City, California, United States, 91402
- Kaiser Permanente - Panorama City
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Paradise, California, United States, 95969
- Feather River Cancer Center
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Pleasant Hill, California, United States, 94523
- East Bay Medical Oncology Hematology Medical Associates Inc-Pleasant Hill
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Pomona, California, United States, 91767
- Pomona Valley Hospital Medical Center
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Redwood City, California, United States, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, United States, 94801
- Kaiser Permanente-Richmond
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Riverside, California, United States, 92505
- Kaiser Permanente Medical Center
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Roseville, California, United States, 95661
- Kaiser Permanente-Roseville
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Sacramento, California, United States, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, United States, 95825
- Kaiser Permanente - Sacramento
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Saint Helena, California, United States, 94574
- Saint Helena Hospital
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San Diego, California, United States, 92134
- Naval Medical Center -San Diego
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San Diego, California, United States, 92120
- Kaiser Permanente at San Diego
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San Francisco, California, United States, 94115
- Kaiser Permanente-San Francisco
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San Jose, California, United States, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Jose, California, United States, 95128
- Santa Clara Valley Medical Center
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San Marcos, California, United States, 92069
- Kaiser Permanente Health Care
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San Pablo, California, United States, 94806
- Doctors Medical Center- JC Robinson Regional Cancer Center
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San Rafael, California, United States, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, United States, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Rosa, California, United States, 95403
- Kaiser Permanente-Santa Rosa
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South San Francisco, California, United States, 94080
- Kaiser Permanente-South San Francisco
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Stanford, California, United States, 94305
- Stanford University Hospitals and Clinics
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Stockton, California, United States, 95210
- Kaiser Permanente-Stockton
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Vacaville, California, United States, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, United States, 94589
- Kaiser Permanente-Vallejo
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Walnut Creek, California, United States, 94596
- Kaiser Permanente-Walnut Creek
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Whittier, California, United States, 90602
- Presbyterian Intercommunity Hospital
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Woodland Hills, California, United States, 91367
- Kaiser Permanente
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Colorado
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Aurora, Colorado, United States, 80012
- The Medical Center of Aurora
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Boulder, Colorado, United States, 80301
- Boulder Community Hospital
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Colorado Springs, Colorado, United States, 80907
- Penrose-Saint Francis Healthcare
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Denver, Colorado, United States, 80210
- Porter Adventist Hospital
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Denver, Colorado, United States, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, United States, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, United States, 80220
- Rose Medical Center
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Denver, Colorado, United States, 80218
- Exempla Saint Joseph Hospital
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Denver, Colorado, United States, 80224-2522
- Colorado Cancer Research Program CCOP
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Denver, Colorado, United States, 80204
- Saint Anthony Central Hospital
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Englewood, Colorado, United States, 80110
- Swedish Medical Center
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Fort Collins, Colorado, United States, 80524
- Poudre Valley Hospital
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Fort Collins, Colorado, United States, 80528
- Front Range Cancer Specialists
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Greeley, Colorado, United States, 80631
- North Colorado Medical Center
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Lafayette, Colorado, United States, 80026
- Kaiser Permanente-Rock Creek
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Littleton, Colorado, United States, 80122
- Littleton Adventist Hospital
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Lone Tree, Colorado, United States, 80124
- Sky Ridge Medical Center
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Longmont, Colorado, United States, 80501
- Longmont United Hospital
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Loveland, Colorado, United States, 80539
- McKee Medical Center
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Parker, Colorado, United States, 80138
- Parker Adventist Hospital
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Pueblo, Colorado, United States, 81004
- Saint Mary Corwin Medical Center
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Thornton, Colorado, United States, 80229
- North Suburban Medical Center
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Wheat Ridge, Colorado, United States, 80033
- Exempla Lutheran Medical Center
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Connecticut
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Farmington, Connecticut, United States, 06030
- University of Connecticut
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Hartford, Connecticut, United States, 06102
- Hartford Hospital
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Hartford, Connecticut, United States, 06105
- Saint Francis Hospital and Medical Center
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Manchester, Connecticut, United States, 06040
- Manchester Memorial Hospital
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Meriden, Connecticut, United States, 06451
- Midstate Medical Center
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Middletown, Connecticut, United States, 06457
- Middlesex Hospital
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New Britain, Connecticut, United States, 06050
- The Hospital of Central Connecticut
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Stamford, Connecticut, United States, 06904
- Stamford Hospital
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Delaware
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Dover, Delaware, United States, 19901
- Bayhealth Medical Center at Kent General
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Lewes, Delaware, United States, 19958
- Beebe Medical Center
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Newark, Delaware, United States, 19718
- Christiana Care Health System-Christiana Hospital
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Seaford, Delaware, United States, 19973
- Nanticoke Memorial Hospital
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District of Columbia
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Washington, District of Columbia, United States, 20010
- Washington Hospital Center
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Washington, District of Columbia, United States, 20057
- Lombardi Comprehensive Cancer Center at Georgetown University
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Washington, District of Columbia, United States, 20016
- Sibley Memorial Hospital
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Washington, District of Columbia, United States, 20002
- Kaiser Permanente-Capitol Hill Medical Center
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Washington, District of Columbia, United States, 20037
- George Washington University Medical Center
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Florida
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Clearwater, Florida, United States, 33756
- Morton Plant Hospital
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Fort Lauderdale, Florida, United States, 33316
- Broward Health Medical Center
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Fort Lauderdale, Florida, United States, 33308
- Holy Cross Hospital
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Jacksonville, Florida, United States, 32207
- Edna Williams Cancer Center at the Baptist Cancer Institute
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Jacksonville, Florida, United States, 32204
- Saint Vincent's Medical Center
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Jupiter, Florida, United States, 33458
- Jupiter Medical Center
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Lakeland, Florida, United States, 33805
- Lakeland Regional Cancer Center
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Lakeland, Florida, United States, 33805
- The Watson Clinic
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Miami, Florida, United States, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Miami, Florida, United States, 33176
- Advanced Medical Specialties -North
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Miami Beach, Florida, United States, 33140
- Mount Sinai Medical Center CCOP
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Ocala, Florida, United States, 34471
- Ocala Oncology Center
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Orlando, Florida, United States, 32803
- Florida Hospital
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Orlando, Florida, United States, 32806
- M D Anderson Cancer Center- Orlando
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Pensacola, Florida, United States, 32504
- Sacred Heart Hospital
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Pensacola, Florida, United States, 32514
- Sacred Heart Medical Oncology Group - Davis Highway
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Georgia
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Atlanta, Georgia, United States, 30309
- Piedmont Hospital
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Augusta, Georgia, United States, 30901
- Augusta Oncology Associates PC-Saint Sebastian
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Columbus, Georgia, United States, 31904
- John B Amos Cancer Center
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Decatur, Georgia, United States, 30033
- Dekalb Medical Center
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Gainesville, Georgia, United States, 30501
- Northeast Georgia Medical Center
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Savannah, Georgia, United States, 31403
- Memorial Health University Medical Center
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Savannah, Georgia, United States, 31405
- Saint Joseph's-Candler Health System
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Valdosta, Georgia, United States, 31603
- South Georgia Medical Center
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Hawaii
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'Aiea, Hawaii, United States, 96701
- Kapiolani Medical Center at Pali Momi
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'Aiea, Hawaii, United States, 96701
- Oncare Hawaii Inc - Kapiolani Medical Center at Pali Momi
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Honolulu, Hawaii, United States, 96813
- Queen's Medical Center
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Honolulu, Hawaii, United States, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, United States, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, United States, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, United States, 96819
- Kaiser Permanente Moanalua Medical Center
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Honolulu, Hawaii, United States, 96813
- University of Hawaii
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Honolulu, Hawaii, United States, 96813
- Oncare Hawaii Inc-POB II
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Honolulu, Hawaii, United States, 96817-3169
- OnCare Hawaii-Liliha
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Honolulu, Hawaii, United States, 96817
- Oncare Hawaii Inc-Kuakini
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Kailua, Hawaii, United States, 96734
- Castle Medical Center
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Lihue, Hawaii, United States, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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Idaho
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Boise, Idaho, United States, 83712
- Saint Luke's Mountain States Tumor Institute
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Boise, Idaho, United States, 83706
- Saint Alphonsus Regional Medical Center
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Fruitland, Idaho, United States, 83619
- Saint Luke's Mountain States Tumor Institute - Fruitland
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Lewiston, Idaho, United States, 83501
- Saint Joseph Regional Medical Center
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Meridian, Idaho, United States, 83642
- Saint Luke's Mountain States Tumor Institute - Meridian
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Meridian, Idaho, United States, 83642
- Idaho Urologic Institute PA
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Nampa, Idaho, United States, 83686
- Saint Luke's Mountain States Tumor Institute - Nampa
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Post Falls, Idaho, United States, 83854
- Kootenai Cancer Center
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Twin Falls, Idaho, United States, 83301
- Saint Luke's Mountain States Tumor Institute-Twin Falls
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Illinois
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Aurora, Illinois, United States, 60504
- Rush - Copley Medical Center
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Bloomington, Illinois, United States, 61701
- Saint Joseph Medical Center
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Bloomington, Illinois, United States, 61701
- Illinois CancerCare-Bloomington
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Canton, Illinois, United States, 61520
- Illinois CancerCare-Canton
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Canton, Illinois, United States, 61520
- Graham Hospital Association
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Carthage, Illinois, United States, 62321
- Illinois CancerCare-Carthage
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Carthage, Illinois, United States, 62321
- Memorial Hospital
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Chicago, Illinois, United States, 60611
- Northwestern University
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Chicago, Illinois, United States, 60612
- University of Illinois
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Chicago, Illinois, United States, 60608
- Mount Sinai Hospital Medical Center
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Chicago, Illinois, United States, 60640
- Weiss Memorial Hospital
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Chicago, Illinois, United States, 60612-3785
- John H Stroger Jr Hospital of Cook County
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Decatur, Illinois, United States, 62526
- Decatur Memorial Hospital
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Eureka, Illinois, United States, 61530
- Illinois CancerCare-Eureka
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Eureka, Illinois, United States, 61530
- Eureka Hospital
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Evanston, Illinois, United States, 60202
- Saint Francis Hospital
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Evanston, Illinois, United States, 60201
- Evanston CCOP-NorthShore University HealthSystem
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Freeport, Illinois, United States, 61032
- FHN Leonard C. Ferguson Cancer Center
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Galesburg, Illinois, United States, 61401
- Illinois CancerCare Galesburg
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Galesburg, Illinois, United States, 61401
- Medical and Surgical Specialists
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Havana, Illinois, United States, 62644
- Mason District Hospital
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Havana, Illinois, United States, 62644
- Illinois CancerCare-Havana
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Highland Park, Illinois, United States, 60035
- Hematology Oncology Associates of Illinois-Highland Park
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Hinsdale, Illinois, United States, 60521
- Hinsdale Hematology Oncology Associates Incorporated
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Joliet, Illinois, United States, 60435
- Joliet Oncology-Hematology Associates Limited
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Kankakee, Illinois, United States, 60901
- Presence Saint Mary's Hospital
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Kewanee, Illinois, United States, 61443
- Illinois CancerCare-Kewanee Clinic
-
La Grange, Illinois, United States, 60525
- Adventist La Grange Memorial Hospital
-
Libertyville, Illinois, United States, 60048
- North Shore Hematology Oncology
-
Macomb, Illinois, United States, 61455
- Illinois CancerCare-Macomb
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Macomb, Illinois, United States, 61455
- Mcdonough District Hospital
-
Moline, Illinois, United States, 61265
- Garneau, Stewart C MD (UIA Investigator)
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Moline, Illinois, United States, 61265
- Porubcin, Michael MD (UIA Investigator)
-
Moline, Illinois, United States, 61265
- Spector, David MD (UIA Investigator)
-
Moline, Illinois, United States, 61265
- Trinity Medical Center
-
Monmouth, Illinois, United States, 61462
- Illinois CancerCare-Monmouth
-
Monmouth, Illinois, United States, 61462
- Holy Family Medical Center
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Mount Vernon, Illinois, United States, 62864
- Good Samaritan Regional Medical Center
-
Naperville, Illinois, United States, 60540
- Hematology Oncology Consultants Limited
-
Naperville, Illinois, United States, 60540
- Edward Hospital/Cancer Center
-
Niles, Illinois, United States, 60714
- Illinois Cancer Specialists-Niles
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Normal, Illinois, United States, 61761
- Community Cancer Center Foundation
-
Normal, Illinois, United States, 61761
- Bromenn Regional Medical Center
-
Normal, Illinois, United States, 61761
- Illinois CancerCare-Community Cancer Center
-
Normal, Illinois, United States, 61761
- Mid-Illinois Hematology Oncology Associates
-
Oak Lawn, Illinois, United States, 60453-2699
- Advocate Christ Medical Center
-
Ottawa, Illinois, United States, 61350
- Illinois CancerCare-Ottawa Clinic
-
Ottawa, Illinois, United States, 61350
- Ottawa Regional Hospital and Healthcare Center
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Park Ridge, Illinois, United States, 60068
- Advocate Lutheran General Hospital
-
Pekin, Illinois, United States, 61554
- Pekin Cancer Treatment Center
-
Pekin, Illinois, United States, 61603
- Illinois CancerCare-Pekin
-
Peoria, Illinois, United States, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, United States, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, United States, 61614
- Proctor Hospital
-
Peoria, Illinois, United States, 61603
- Methodist Medical Center of Illinois
-
Peoria, Illinois, United States, 61615
- Illinois Oncology Research Association CCOP
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Peru, Illinois, United States, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, United States, 61354
- Illinois Valley Hospital
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Princeton, Illinois, United States, 61356
- Illinois CancerCare-Princeton
-
Princeton, Illinois, United States, 61356
- Perry Memorial Hospital
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River Forest, Illinois, United States, 60305
- West Suburban Cancer Center
-
Rockford, Illinois, United States, 61104
- Swedish American Hospital
-
Rockford, Illinois, United States, 61107
- SwedishAmerican Regional Cancer Center/ACT
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Skokie, Illinois, United States, 60076
- Hematology Oncology Associates of Illinois - Skokie
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Spring Valley, Illinois, United States, 61362
- Illinois CancerCare-Spring Valley
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Springfield, Illinois, United States, 62781-0001
- Memorial Medical Center
-
Urbana, Illinois, United States, 61801
- Carle Foundation - Carle Cancer Center
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Indiana
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Beech Grove, Indiana, United States, 46107
- Saint Francis Hospital and Health Centers
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Elkhart, Indiana, United States, 46515
- Elkhart General Hospital
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Elkhart, Indiana, United States, 46514
- Michiana Hematology Oncology PC-Elkhart
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Elkhart, Indiana, United States, 46514-2098
- Elkhart Clinic
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Fort Wayne, Indiana, United States, 46845
- Fort Wayne Medical Oncology and Hematology Inc - State Boulevard
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Indianapolis, Indiana, United States, 46237
- Franciscan St. Francis Health
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Indianapolis, Indiana, United States, 46219
- Central Indiana Cancer Centers - Indianapolis
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Kokomo, Indiana, United States, 46904
- Community Howard Regional Health
-
La Porte, Indiana, United States, 46350
- Indiana University Health La Porte Hospital
-
Lafayette, Indiana, United States, 47904
- IU Health Arnett
-
Merrillville, Indiana, United States, 46410
- Premier Oncology Hematology Associates
-
Michigan City, Indiana, United States, 46360
- Saint Anthony Memorial Health Center
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Mishawaka, Indiana, United States, 46545-1470
- Saint Joseph Regional Medical Center-Mishawaka
-
Mishawaka, Indiana, United States, 46545
- Cancer Care Partners LLC
-
Mishawaka, Indiana, United States, 46545-1470
- Michiana Hematology Oncology PC-Mishawaka
-
Munster, Indiana, United States, 46321
- The Community Hospital
-
Plymouth, Indiana, United States, 46563
- Michiana Hematology Oncology PC-Plymouth
-
Richmond, Indiana, United States, 47374
- Reid Hospital and Health Care Services
-
South Bend, Indiana, United States, 46601
- Memorial Hospital of South Bend
-
South Bend, Indiana, United States, 46601
- Michiana Hematology Oncology PC-South Bend
-
South Bend, Indiana, United States, 46617
- South Bend Clinic
-
South Bend, Indiana, United States, 46601
- Northern Indiana Cancer Research Consortium
-
Westville, Indiana, United States, 46391
- Michiana Hematology Oncology-PC Westville
-
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Iowa
-
Ames, Iowa, United States, 50010
- McFarland Clinic
-
Bettendorf, Iowa, United States, 52722
- Constantinou, Costas L MD (UIA Investigator)
-
Bettendorf, Iowa, United States, 52722
- Hematology Oncology Associates-Quad Cities
-
Cedar Rapids, Iowa, United States, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, United States, 52403
- Oncology Associates at Mercy Medical Center
-
Cedar Rapids, Iowa, United States, 52402
- Saint Luke's Hospital
-
Cedar Rapids, Iowa, United States, 52403
- Cedar Rapids Oncology Association
-
Cedar Rapids, Iowa, United States, 52402
- Helen G Nassif Community Cancer Center
-
Clive, Iowa, United States, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, United States, 50325
- Medical Oncology and Hematology Associates-West Des Moines
-
Davenport, Iowa, United States, 52803
- Genesis Medical Center - East Campus
-
Des Moines, Iowa, United States, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, United States, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, United States, 50309
- Medical Oncology and Hematology Associates-Des Moines
-
Des Moines, Iowa, United States, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, United States, 50309
- Iowa Oncology Research Association CCOP
-
Des Moines, Iowa, United States, 50314
- Medical Oncology and Hematology Associates
-
Iowa City, Iowa, United States, 52242
- University of Iowa Hospitals and Clinics
-
Mason City, Iowa, United States, 50401
- Mercy Medical Center - North Iowa
-
Ottumwa, Iowa, United States, 52501
- Ottumwa Regional Health Center
-
Sioux City, Iowa, United States, 51104
- Saint Luke's Regional Medical Center
-
Sioux City, Iowa, United States, 51101
- Siouxland Hematology Oncology Associates
-
Sioux City, Iowa, United States, 51104
- Mercy Medical Center-Sioux City
-
Waterloo, Iowa, United States, 50702
- Covenant Medical Center
-
West Des Moines, Iowa, United States, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, United States, 50266
- Mercy Medical Center-West Lakes
-
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Kansas
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Chanute, Kansas, United States, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, United States, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, United States, 67042
- Cancer Center of Kansas - El Dorado
-
Emporia, Kansas, United States, 66801
- Newman Regional Health
-
Fort Scott, Kansas, United States, 66701
- Cancer Center of Kansas - Fort Scott
-
Great Bend, Kansas, United States, 67530
- Saint Rose Ambulatory and Surgery Center
-
Hays, Kansas, United States, 67601
- Hays Medical Center
-
Hutchinson, Kansas, United States, 65702
- Promise Regional Medical Center-Hutchinson
-
Independence, Kansas, United States, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, United States, 66160
- University of Kansas Medical Center
-
Kansas City, Kansas, United States, 66112
- Kansas City Cancer Center-West
-
Kingman, Kansas, United States, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, United States, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, United States, 67901
- Cancer Center of Kansas-Liberal
-
McPherson, Kansas, United States, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, United States, 67114
- Cancer Center of Kansas - Newton
-
Overland Park, Kansas, United States, 66209
- Menorah Medical Center
-
Overland Park, Kansas, United States, 66213
- Saint Luke's South Hospital
-
Overland Park, Kansas, United States, 66210
- Kansas City Cancer Centers-Southwest
-
Parsons, Kansas, United States, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, United States, 66762
- Via Christi Hospital-Pittsburg
-
Prairie Village, Kansas, United States, 66208
- Kansas City CCOP
-
Pratt, Kansas, United States, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, United States, 67401
- Salina Regional Health Center
-
Salina, Kansas, United States, 67401
- Cancer Center of Kansas - Salina
-
Shawnee Mission, Kansas, United States, 66204
- Kansas City Cancer Center-Shawnee Mission
-
Topeka, Kansas, United States, 66606
- Saint Francis Hospital and Medical Center - Topeka
-
Topeka, Kansas, United States, 66604
- Stormont-Vail Regional Health Center
-
Wellington, Kansas, United States, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, United States, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, United States, 67208
- Associates In Womens Health
-
Wichita, Kansas, United States, 67214
- Cancer Center of Kansas - Main Office
-
Wichita, Kansas, United States, 67214
- Via Christi Regional Medical Center
-
Wichita, Kansas, United States, 67214
- Wichita CCOP
-
Winfield, Kansas, United States, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Corbin, Kentucky, United States, 40701
- Baptist Regional Medical Center
-
Lexington, Kentucky, United States, 40536
- University Of Kentucky
-
Lexington, Kentucky, United States, 40503
- Baptist Health Lexington
-
Louisville, Kentucky, United States, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, United States, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, United States, 40202
- Norton Health Care Pavilion - Downtown
-
-
Louisiana
-
Alexandria, Louisiana, United States, 71301
- Christus Saint Frances Cabrini Hospital
-
Baton Rouge, Louisiana, United States, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, United States, 70809
- Hematology/Oncology Clinic LLP
-
Baton Rouge, Louisiana, United States, 70809
- Ochsner Clinic Foundation-Baton Rouge
-
Covington, Louisiana, United States, 70433
- Ochsner North Shore Medical Center
-
New Orleans, Louisiana, United States, 70112
- Tulane University Health Sciences Center
-
New Orleans, Louisiana, United States, 70112
- Louisiana State University Health Science Center
-
New Orleans, Louisiana, United States, 70112
- Interim LSU Public Hospital
-
New Orleans, Louisiana, United States, 70115
- Ochsner Baptist Medical Center
-
New Orleans, Louisiana, United States, 70121
- Ochsner Clinic CCOP
-
Shreveport, Louisiana, United States, 71101
- Christus Schumpert Saint Mary's Place
-
-
Maine
-
Augusta, Maine, United States, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, United States, 04401
- Eastern Maine Medical Center
-
Portland, Maine, United States, 04101
- Mercy Hospital
-
Rockport, Maine, United States, 04856
- Penobscot Bay Medical Center
-
Scarborough, Maine, United States, 04074
- Maine Center for Cancer Medicine and Blood Disorders-Scarborough
-
-
Maryland
-
Annapolis, Maryland, United States, 21401
- Anne Arundel Medical Center
-
Baltimore, Maryland, United States, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, United States, 21229
- Saint Agnes Hospital
-
Baltimore, Maryland, United States, 21287-8936
- Johns Hopkins University
-
Baltimore, Maryland, United States, 21244
- Kaiser Permanente-Woodlawn Medical Center
-
Baltimore, Maryland, United States, 21237
- Franklin Square Hospital Center
-
Baltimore, Maryland, United States, 21218
- The Union Memorial Hospital
-
Columbia, Maryland, United States, 21044
- Maryland Oncology Hematology PA-Columbia
-
Easton, Maryland, United States, 21601
- The Memorial Hospital at Easton
-
Elkton, Maryland, United States, 21921
- Union Hospital of Cecil County
-
Frederick, Maryland, United States, 21701
- Frederick Memorial Hospital
-
Gaithersburg, Maryland, United States, 20879
- Kaiser Permanente-Gaithersburg Medical Center
-
Largo, Maryland, United States, 20774
- Kaiser Permanente - Largo Medical Center
-
Salisbury, Maryland, United States, 21801
- Peninsula Regional Medical Center
-
Silver Spring, Maryland, United States, 20910
- Holy Cross Hospital
-
-
Massachusetts
-
Beverly, Massachusetts, United States, 01915
- Beverly Hospital
-
Boston, Massachusetts, United States, 02111
- Tufts Medical Center
-
Boston, Massachusetts, United States, 02118
- Boston Medical Center
-
Burlington, Massachusetts, United States, 01805
- Lahey Hospital and Medical Center
-
Fall River, Massachusetts, United States, 02721
- Saint Anne's Hospital
-
Gloucester, Massachusetts, United States, 01930
- Addison Gilbert Hospital
-
Lowell, Massachusetts, United States, 01854
- Lowell General Hospital
-
Methuen, Massachusetts, United States, 01844
- Holy Family Hospital
-
Newton, Massachusetts, United States, 02462
- Newton-Wellesley Hospital
-
Pittsfield, Massachusetts, United States, 01201
- Berkshire Hematology Oncology PC
-
Plymouth, Massachusetts, United States, 02360
- Jordan Hospital
-
Springfield, Massachusetts, United States, 01199
- Baystate Medical Center
-
-
Michigan
-
Adrian, Michigan, United States, 49221
- Bixby Medical Center
-
Adrian, Michigan, United States, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, United States, 48109
- University of Michigan
-
Ann Arbor, Michigan, United States, 48106-0995
- Saint Joseph Mercy Hospital
-
Ann Arbor, Michigan, United States, 48106
- Michigan Cancer Research Consortium Community Clinical Oncology Program
-
Battle Creek, Michigan, United States, 49017
- Bronson Battle Creek
-
Bay City, Michigan, United States, 48708
- Bay Regional Medical Center
-
Big Rapids, Michigan, United States, 49307
- Mecosta County Medical Center
-
Clarkston, Michigan, United States, 48346
- Great Lakes Cancer Institute
-
Dearborn, Michigan, United States, 48124
- Oakwood Hospital
-
Detroit, Michigan, United States, 48202
- Henry Ford Hospital
-
Detroit, Michigan, United States, 48236
- Saint John Hospital and Medical Center
-
Detroit, Michigan, United States, 48202
- Wayne State University
-
Escanaba, Michigan, United States, 49431
- Green Bay Oncology - Escanaba
-
Farmington Hills, Michigan, United States, 48334
- Weisberg Cancer Treatment Center
-
Flint, Michigan, United States, 48502
- Hurley Medical Center
-
Flint, Michigan, United States, 48532
- Genesys Regional Medical Center-West Flint Campus
-
Flint, Michigan, United States, 48532
- Singh and Arora Hematology Oncology PC
-
Flint, Michigan, United States, 48503
- Genesys Hurley Cancer Institute
-
Flint, Michigan, United States, 48532
- McLaren Regional Cancer Center
-
Grand Blanc, Michigan, United States, 48439
- Genesys Regional Medical Center
-
Grand Rapids, Michigan, United States, 49503
- Spectrum Health at Butterworth Campus
-
Grand Rapids, Michigan, United States, 49503
- Grand Rapids Clinical Oncology Program
-
Grand Rapids, Michigan, United States, 49503
- Saint Mary's Health Care
-
Iron Mountain, Michigan, United States, 49801
- Green Bay Oncology - Iron Mountain
-
Jackson, Michigan, United States, 49201
- Allegiance Health
-
Kalamazoo, Michigan, United States, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, United States, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, United States, 49001
- Borgess Medical Center
-
Lansing, Michigan, United States, 48912
- Sparrow Hospital
-
Lansing, Michigan, United States, 48910
- Michigan State University - Breslin Cancer Center
-
Lapeer, Michigan, United States, 48446
- Great Lakes Cancer Institute-Lapeer Campus
-
Livonia, Michigan, United States, 48154
- Saint Mary Mercy Hospital
-
Marquette, Michigan, United States, 49855
- Marquette General Hospital
-
Monroe, Michigan, United States, 48162
- Mercy Memorial Hospital
-
Monroe, Michigan, United States, 48162
- Community Cancer Center of Monroe
-
Mount Clemens, Michigan, United States, 48043
- Mount Clemens Regional Medical Center
-
Muskegon, Michigan, United States, 49444
- Mercy Health Partners-Mercy Campus
-
Owosso, Michigan, United States, 48867
- Memorial Healthcare Center
-
Petoskey, Michigan, United States, 49770
- Northern Michigan Regional Hospital
-
Pontiac, Michigan, United States, 48341-2985
- Saint Joseph Mercy Oakland
-
Port Huron, Michigan, United States, 48060
- Saint Joseph Mercy Port Huron
-
Reed City, Michigan, United States, 49677
- Spectrum Health Reed City Hospital
-
Royal Oak, Michigan, United States, 48073
- William Beaumont Hospital
-
Saginaw, Michigan, United States, 48601
- Saint Mary's of Michigan
-
Saint Joseph, Michigan, United States, 49085
- Marie Yeager Cancer Center
-
Saint Joseph, Michigan, United States, 49085
- Lakeland Hospital
-
Southfield, Michigan, United States, 48075
- Providence Hospital
-
Traverse City, Michigan, United States, 49684
- Munson Medical Center
-
Troy, Michigan, United States, 48098
- William Beaumont Hospital - Troy
-
Warren, Michigan, United States, 48093
- Saint John Macomb-Oakland Hospital
-
-
Minnesota
-
Bemidji, Minnesota, United States, 56601
- Sanford Clinic North-Bemidgi
-
Brainerd, Minnesota, United States, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, United States, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, United States, 55433
- Mercy Hospital
-
Duluth, Minnesota, United States, 55805
- Saint Luke's Hospital of Duluth
-
Duluth, Minnesota, United States, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, United States, 55805
- Miller-Dwan Hospital
-
Duluth, Minnesota, United States, 55805
- Essentia Health Duluth Clinic CCOP
-
Edina, Minnesota, United States, 55435
- Fairview-Southdale Hospital
-
Fergus Falls, Minnesota, United States, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, United States, 55432
- Unity Hospital
-
Hutchinson, Minnesota, United States, 55350
- Hutchinson Area Health Care
-
Mankato, Minnesota, United States, 56002
- Mayo Clinic Health System in Mankato
-
Maplewood, Minnesota, United States, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, United States, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, United States, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, United States, 55407
- Abbott-Northwestern Hospital
-
New Ulm, Minnesota, United States, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, United States, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, United States, 55905
- Mayo Clinic
-
Saint Cloud, Minnesota, United States, 56303
- Saint Cloud Hospital
-
Saint Cloud, Minnesota, United States, 56303
- CentraCare Clinic
-
Saint Louis Park, Minnesota, United States, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, United States, 55416
- Metro-Minnesota CCOP
-
Saint Paul, Minnesota, United States, 55101
- Regions Hospital
-
Saint Paul, Minnesota, United States, 55102
- United Hospital
-
Shakopee, Minnesota, United States, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, United States, 55082
- Lakeview Hospital
-
Waconia, Minnesota, United States, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, United States, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, United States, 55125
- Minnesota Oncology and Hematology PA-Woodbury
-
-
Mississippi
-
Gulfport, Mississippi, United States, 39502
- Gulfport Memorial Hospital
-
Hattiesburg, Mississippi, United States, 39404
- Forest General Hospital
-
Jackson, Mississippi, United States, 39216
- University of Mississippi Medical Center
-
Pascagoula, Mississippi, United States, 39581
- Singing River Hospital
-
-
Missouri
-
Bolivar, Missouri, United States, 65613
- Central Care Cancer Center-Carrie J Babb Cancer Center
-
Branson, Missouri, United States, 65616
- CoxHealth Cancer Center
-
Cape Girardeau, Missouri, United States, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, United States, 63703
- Southeast Cancer Center
-
Chesterfield, Missouri, United States, 63017
- Saint Luke's Hospital
-
Columbia, Missouri, United States, 65203
- University of Missouri - Ellis Fischel
-
Jefferson City, Missouri, United States, 65109
- Capital Region Medical Center-Goldschmidt Cancer Center
-
Joplin, Missouri, United States, 64804
- Freeman Health System
-
Joplin, Missouri, United States, 64804
- Saint John's Regional Medical Center
-
Kansas City, Missouri, United States, 64116
- North Kansas City Hospital
-
Kansas City, Missouri, United States, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, United States, 64132
- Research Medical Center
-
Kansas City, Missouri, United States, 64108
- Truman Medical Center
-
Kansas City, Missouri, United States, 64118
- Heartland Hematology and Oncology Associates Incorporated
-
Kansas City, Missouri, United States, 64111
- Saint Luke's Cancer Institute
-
Kansas City, Missouri, United States, 64131
- Kansas City Cancer Center - South
-
Kansas City, Missouri, United States, 64154
- Kansas City Cancer Centers - North
-
Lee's Summit, Missouri, United States, 64086
- Saint Luke's East - Lee's Summit
-
Lee's Summit, Missouri, United States, 64064
- Kansas City Cancer Center-Lee's Summit
-
Liberty, Missouri, United States, 64068
- Liberty Radiation Oncology Clinic
-
Rolla, Missouri, United States, 65401
- Phelps County Regional Medical Center
-
Rolla, Missouri, United States, 65401
- Saint John's Clinic-Rolla-Cancer and Hematology
-
Saint Joseph, Missouri, United States, 64506
- Heartland Regional Medical Center
-
Saint Joseph, Missouri, United States, 64507
- Saint Joseph Oncology Inc
-
Saint Louis, Missouri, United States, 63110
- Washington University School of Medicine
-
Saint Louis, Missouri, United States, 63110
- Saint Louis University Hospital
-
Saint Louis, Missouri, United States, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, United States, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Saint Louis, Missouri, United States, 63141
- Saint John's Mercy Medical Center
-
Saint Louis, Missouri, United States, 63141
- Saint Louis-Cape Girardeau CCOP
-
Saint Louis, Missouri, United States, 63141
- Comprehensive Cancer Care PC
-
Springfield, Missouri, United States, 65802
- Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield
-
Springfield, Missouri, United States, 65807
- Cox Medical Center
-
Springfield, Missouri, United States, 65804
- Saint John's Hospital
-
-
Montana
-
Billings, Montana, United States, 59101
- Saint Vincent Healthcare
-
Billings, Montana, United States, 59101
- Montana Cancer Consortium CCOP
-
Billings, Montana, United States, 59102
- Hematology-Oncology Centers of the Northern Rockies PC
-
Billings, Montana, United States, 59107-7000
- Billings Clinic
-
Bozeman, Montana, United States, 59715
- Bozeman Deaconess Hospital
-
Bozeman, Montana, United States, 59715
- Bozeman Deaconess Cancer Center
-
Butte, Montana, United States, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, United States, 59405
- Great Falls Clinic
-
Great Falls, Montana, United States, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Great Falls, Montana, United States, 59405
- Big Sky Oncology
-
Havre, Montana, United States, 59501
- Northern Montana Hospital
-
Helena, Montana, United States, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, United States, 59901
- Kalispell Regional Medical Center
-
Kalispell, Montana, United States, 59901
- Glacier Oncology PLLC
-
Kalispell, Montana, United States, 59901
- Kalispell Medical Oncology
-
Missoula, Montana, United States, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, United States, 59802
- Montana Cancer Specialists
-
-
Nebraska
-
Kearney, Nebraska, United States, 68847
- Good Samaritan Hospital
-
Lincoln, Nebraska, United States, 68510
- Lincoln Medical Education Foundation Cancer Resource Center
-
Omaha, Nebraska, United States, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, United States, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, United States, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, United States, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, United States, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, United States, 68106
- Missouri Valley Cancer Consortium CCOP
-
-
Nevada
-
Las Vegas, Nevada, United States, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, United States, 89106
- Nevada Cancer Research Foundation CCOP
-
-
New Hampshire
-
Concord, New Hampshire, United States, 03301
- New Hampshire Oncology-Hematology PA
-
Hooksett, New Hampshire, United States, 03106
- New Hampshire Oncology Hematology Associates
-
Laconia, New Hampshire, United States, 03246
- LRGHealthcare-Lakes Region General Hospital
-
Nashua, New Hampshire, United States, 03060
- Saint Joseph Hospital
-
Portsmouth, New Hampshire, United States, 03802
- Portsmouth Regional Hospital
-
-
New Jersey
-
Camden, New Jersey, United States, 08103
- Cooper Hospital University Medical Center
-
Englewood, New Jersey, United States, 07631
- Englewood Hospital and Medical Center
-
Flemington, New Jersey, United States, 08822
- Hunterdon Medical Center
-
Hamilton, New Jersey, United States, 08690
- Cancer Institute of New Jersey at Hamilton
-
Neptune, New Jersey, United States, 07753
- Jersey Shore Medical Center
-
New Brunswick, New Jersey, United States, 08903
- Cancer Institute of New Jersey
-
Newark, New Jersey, United States, 07112
- Newark Beth Israel Medical Center
-
Pennington, New Jersey, United States, 08534
- Capital Health Medical Center-Hopewell
-
Ridgewood, New Jersey, United States, 07450
- Valley Hospital
-
Somerville, New Jersey, United States, 08876
- Somerset Medical Center
-
Sparta, New Jersey, United States, 07871
- Sparta Cancer Treatment Center
-
Toms River, New Jersey, United States, 08755
- Community Medical Center
-
Vineland, New Jersey, United States, 08360
- South Jersey Healthcare
-
-
New Mexico
-
Albuquerque, New Mexico, United States, 87106
- University of New Mexico
-
Albuquerque, New Mexico, United States, 87109
- New Mexico Oncology Hematology Consultants
-
Albuquerque, New Mexico, United States, 87106
- Hematology Oncology Associates
-
Albuquerque, New Mexico, United States, 87110
- Presbyterian Kaseman Hospital
-
Las Cruces, New Mexico, United States, 88011
- Memorial Medical Center - Las Cruces
-
Santa Fe, New Mexico, United States, 87505
- New Mexico Cancer Care Associates
-
-
New York
-
Albany, New York, United States, 12208
- New York Oncology Hematology PC -Albany Medical Center
-
Albany, New York, United States, 12206
- New York Oncology Hematology PC - Albany
-
Amsterdam, New York, United States, 12010
- New York Oncology Hematology PC - Amsterdam
-
Bronx, New York, United States, 10461
- Albert Einstein College of Medicine
-
Bronx, New York, United States, 10467-2490
- Montefiore Medical Center
-
Brooklyn, New York, United States, 11219
- Maimonides Medical Center
-
Brooklyn, New York, United States, 11203
- Kings County Hospital
-
Brooklyn, New York, United States, 11203
- State University of New York Downstate Medical Center
-
Buffalo, New York, United States, 14263
- Roswell Park Cancer Institute
-
Cooperstown, New York, United States, 13326
- Mary Imogene Bassett Hospital
-
East Syracuse, New York, United States, 13057
- Hematology Oncology Associates of Central New York PC
-
Hudson, New York, United States, 12534
- New York Oncology Hematology PC-Hudson
-
Johnson City, New York, United States, 13790
- Broome Oncology LLC
-
Lake Success, New York, United States, 11042
- Monter Cancer Center
-
Latham, New York, United States, 12110
- New York Oncology Hematology PC - Latham
-
Manhasset, New York, United States, 11030
- North Shore University Hospital
-
Manhasset, New York, United States, 11030
- North Shore-LIJ Health System CCOP
-
Mineola, New York, United States, 11501
- Winthrop University Hospital
-
New Hyde Park, New York, United States, 11040
- Long Island Jewish Medical Center
-
New York, New York, United States, 10032
- Columbia University Medical Center
-
New York, New York, United States, 10029
- Mount Sinai Medical Center
-
Poughkeepsie, New York, United States, 12601
- Vassar Brothers Medical Center
-
Poughkeepsie, New York, United States, 12601
- Saint Francis
-
Rochester, New York, United States, 14642
- University of Rochester
-
Staten Island, New York, United States, 10305
- Staten Island University Hospital
-
Stony Brook, New York, United States, 11794
- Stony Brook University Medical Center
-
-
North Carolina
-
Asheboro, North Carolina, United States, 27203
- Randolph Hospital
-
Asheville, North Carolina, United States, 28801
- Mission Hospitals
-
Asheville, North Carolina, United States, 28816
- Hope Women's Cancer Centers-Asheville
-
Burlington, North Carolina, United States, 27216
- Alamance Regional Medical Center
-
Cary, North Carolina, United States, 27518
- Waverly Hematology Oncology
-
Charlotte, North Carolina, United States, 28203
- Carolinas Medical Center
-
Charlotte, North Carolina, United States, 28204
- Presbyterian Hospital
-
Concord, North Carolina, United States, 28025
- Carolinas Medical Center - Northeast
-
Gastonia, North Carolina, United States, 28054
- Gaston Memorial Hospital
-
Goldsboro, North Carolina, United States, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, United States, 27403
- Cone Health Cancer Center
-
Hendersonville, North Carolina, United States, 28791
- Margaret R Pardee Memorial Hospital
-
Hendersonville, North Carolina, United States, 28792
- Park Ridge Hospital Breast Health Center
-
Kinston, North Carolina, United States, 28501
- Kinston Medical Specialists PA
-
Monroe, North Carolina, United States, 28112
- Carolinas Medical Center-Union
-
Pinehurst, North Carolina, United States, 28374
- FirstHealth of the Carolinas-Moore Regional Hosiptal
-
Raleigh, North Carolina, United States, 27607
- Rex Cancer Center
-
Raleigh, North Carolina, United States, 27614
- Rex Cancer Center of Wakefield
-
Reidsville, North Carolina, United States, 27320
- Annie Penn Memorial Hospital
-
Rutherfordton, North Carolina, United States, 28139
- Rutherford Hospital
-
Shelby, North Carolina, United States, 28150
- Cleveland Regional Medical Center
-
Statesville, North Carolina, United States, 28677
- Iredell Memorial Hospital
-
Washington, North Carolina, United States, 27889
- Marion L Shepard Cancer Center
-
Wilmington, North Carolina, United States, 28401
- New Hanover Regional Medical Center
-
Winston-Salem, North Carolina, United States, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, United States, 27103
- Forsyth Memorial Hospital
-
-
North Dakota
-
Bismarck, North Dakota, United States, 58501
- Sanford Bismarck Medical Center
-
Bismarck, North Dakota, United States, 58501
- Bismarck Cancer Center
-
Bismarck, North Dakota, United States, 58501
- Mid Dakota Clinic
-
Bismarck, North Dakota, United States, 58501
- Saint Alexius Medical Center
-
Fargo, North Dakota, United States, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, United States, 58122
- Sanford Clinic North-Fargo
-
Fargo, North Dakota, United States, 58122
- Sanford Medical Center-Fargo
-
Fargo, North Dakota, United States, 58122
- Roger Maris Cancer Center
-
Grand Forks, North Dakota, United States, 58201
- Altru Cancer Center
-
-
Ohio
-
Akron, Ohio, United States, 44307
- Akron General Medical Center
-
Akron, Ohio, United States, 44304
- Summa Akron City Hospital
-
Barberton, Ohio, United States, 44203
- Summa Barberton Hospital
-
Beachwood, Ohio, United States, 44122
- Cleveland Clinic Cancer Center Beachwood
-
Belpre, Ohio, United States, 45714
- Strecker Cancer Center-Belpre
-
Bowling Green, Ohio, United States, 43402
- Toledo Clinic Cancer Centers-Bowling Green
-
Canton, Ohio, United States, 44710
- Aultman Health Foundation
-
Canton, Ohio, United States, 44708
- Mercy Medical Center
-
Chillicothe, Ohio, United States, 45601
- Adena Regional Medical Center
-
Cleveland, Ohio, United States, 44106
- Case Western Reserve University
-
Cleveland, Ohio, United States, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, United States, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Columbus, Ohio, United States, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, United States, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, United States, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, United States, 43228
- Doctors Hospital
-
Columbus, Ohio, United States, 43215
- Grant Medical Center
-
Columbus, Ohio, United States, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, United States, 43215
- Columbus CCOP
-
Dayton, Ohio, United States, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, United States, 45409
- Miami Valley Hospital
-
Dayton, Ohio, United States, 45415
- Samaritan North Health Center
-
Dayton, Ohio, United States, 45405
- Grandview Hospital
-
Dayton, Ohio, United States, 45420
- Dayton CCOP
-
Delaware, Ohio, United States, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, United States, 43015
- Grady Memorial Hospital
-
Elyria, Ohio, United States, 44035
- Hematology Oncology Center Incorporated
-
Elyria, Ohio, United States, 44035
- Community Health Partners Regional Medical Center
-
Findlay, Ohio, United States, 45840
- Blanchard Valley Hospital
-
Franklin, Ohio, United States, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Greenville, Ohio, United States, 45331
- Wayne Hospital
-
Independence, Ohio, United States, 44131
- Cleveland Clinic Cancer Center Independence
-
Kettering, Ohio, United States, 45429
- Kettering Medical Center
-
Lancaster, Ohio, United States, 43130
- Fairfield Medical Center
-
Lima, Ohio, United States, 45801
- Saint Rita's Medical Center
-
Lima, Ohio, United States, 45804
- Lima Memorial Hospital
-
Mansfield, Ohio, United States, 44903
- Mansfield General Hospital-MedCentral Health System
-
Marietta, Ohio, United States, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, United States, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Maumee, Ohio, United States, 43537-1839
- Toledo Clinic Cancer Centers-Maumee
-
Mayfield Heights, Ohio, United States, 44124
- Hillcrest Hospital Cancer Center
-
Mount Vernon, Ohio, United States, 43050
- Knox Community Hospital
-
Newark, Ohio, United States, 43055
- Licking Memorial Hospital
-
Oregon, Ohio, United States, 43616
- Saint Charles Hospital
-
Oregon, Ohio, United States, 43616
- Toledo Clinic Cancer Centers-Oregon
-
Parma, Ohio, United States, 44129
- Parma Community General Hospital
-
Portsmouth, Ohio, United States, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, United States, 44870
- North Coast Cancer Care
-
Springfield, Ohio, United States, 45505
- Springfield Regional Medical Center
-
Steubenville, Ohio, United States, 43952
- Trinity's Tony Teramana Cancer Center
-
Strongsville, Ohio, United States, 44136
- Cleveland Clinic Cancer Center-Strongsville
-
Sylvania, Ohio, United States, 43560
- Flower Hospital
-
Tiffin, Ohio, United States, 44883
- Mercy Hospital of Tiffin
-
Toledo, Ohio, United States, 43608
- Saint Vincent Mercy Medical Center
-
Toledo, Ohio, United States, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, United States, 43614
- University of Toledo
-
Toledo, Ohio, United States, 43617
- Toledo Community Hospital Oncology Program CCOP
-
Toledo, Ohio, United States, 43606
- The Toledo Hospital/Toledo Children's Hospital
-
Toledo, Ohio, United States, 43623
- Mercy Cancer Center at Saint Anne Mercy Hospital
-
Troy, Ohio, United States, 45373
- Upper Valley Medical Center
-
Wauseon, Ohio, United States, 43567
- Fulton County Health Center
-
Westerville, Ohio, United States, 43081
- Saint Ann's Hospital
-
Wooster, Ohio, United States, 44691
- Cleveland Clinic Wooster Specialty Center
-
Wright-Patterson Air Force Base, Ohio, United States, 45433-5529
- Wright-Patterson Medical Center
-
Xenia, Ohio, United States, 45385
- Greene Memorial Hospital
-
Zanesville, Ohio, United States, 43701
- Genesis HealthCare System
-
-
Oklahoma
-
Lawton, Oklahoma, United States, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Norman, Oklahoma, United States, 73071
- Cancer Care Associates-Norman
-
Oklahoma City, Oklahoma, United States, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, United States, 73120
- Cancer Care Associates-Mercy
-
Tulsa, Oklahoma, United States, 74136
- Natalie W Bryant Cancer Center
-
-
Oregon
-
Clackamas, Oregon, United States, 97015
- Clackamas Radiation Oncology Center
-
Grants Pass, Oregon, United States, 97527
- Three Rivers Community Hospital
-
Gresham, Oregon, United States, 97030
- Legacy Mount Hood Medical Center
-
Medford, Oregon, United States, 97504
- Asante Health System
-
Medford, Oregon, United States, 97504
- Providence Medford Medical Center
-
Medford, Oregon, United States, 97504
- Rogue Valley Medical Center
-
Milwaukie, Oregon, United States, 97222
- Providence Milwaukie Hospital
-
Newberg, Oregon, United States, 97132
- Providence Newberg Medical Center
-
Oregon City, Oregon, United States, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, United States, 97210
- Legacy Good Samaritan Hospital and Medical Center
-
Portland, Oregon, United States, 97213
- Providence Portland Medical Center
-
Portland, Oregon, United States, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, United States, 97227
- Kaiser Permanente
-
Portland, Oregon, United States, 97225
- Columbia River Oncology Program
-
The Dalles, Oregon, United States, 97058
- Mid-Columbia Medical Center
-
Tualatin, Oregon, United States, 97062
- Legacy Meridian Park Hospital
-
-
Pennsylvania
-
Abington, Pennsylvania, United States, 19001
- Abington Memorial Hospital
-
Allentown, Pennsylvania, United States, 18105
- Lehigh Valley Hospital
-
Bethlehem, Pennsylvania, United States, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bryn Mawr, Pennsylvania, United States, 19010
- Bryn Mawr Hospital
-
Danville, Pennsylvania, United States, 17822-2001
- Geisinger Medical Center
-
Doylestown, Pennsylvania, United States, 18901
- Doylestown Hospital
-
Ephrata, Pennsylvania, United States, 17522
- Ephrata Cancer Center
-
Erie, Pennsylvania, United States, 16505
- The Regional Cancer Center
-
Gettysburg, Pennsylvania, United States, 17325
- Adams Cancer Center
-
Hanover, Pennsylvania, United States, 17331
- Cherry Tree Cancer Center
-
Harrisburg, Pennsylvania, United States, 17110
- PinnacleHealth Fox Chase Regional Cancer Center at Polyclinic Hospital
-
Hazleton, Pennsylvania, United States, 18201
- Geisinger Medical Center-Cancer Center Hazelton
-
Hershey, Pennsylvania, United States, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Kingston, Pennsylvania, United States, 18704
- Medical Oncology Associates
-
Kittanning, Pennsylvania, United States, 16201
- Armstrong Center for Medicine and Health
-
Media, Pennsylvania, United States, 19063
- Riddle Hospital
-
Monroeville, Pennsylvania, United States, 15146
- Forbes Regional Hospital
-
Natrona Heights, Pennsylvania, United States, 15065
- Alle-Kiski Medical Center
-
Paoli, Pennsylvania, United States, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, United States, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, United States, 19107
- Pennsylvania Hospital
-
Phoenixville, Pennsylvania, United States, 19460
- Phoenixville Hospital
-
Pittsburgh, Pennsylvania, United States, 15232
- University of Pittsburgh
-
Pittsburgh, Pennsylvania, United States, 15212
- Allegheny Cancer Center at Allegheny General Hospital
-
Pittsburgh, Pennsylvania, United States, 15224-1791
- Western Pennsylvania Hospital
-
Pottstown, Pennsylvania, United States, 19464
- Pottstown Memorial Medical Center
-
Reading, Pennsylvania, United States, 19605
- Saint Joseph Medical Center
-
Sayre, Pennsylvania, United States, 18840
- Guthrie Clinic-Robert Packer Hospital
-
Scranton, Pennsylvania, United States, 18510
- Scranton Hematology Oncology
-
Scranton, Pennsylvania, United States, 18501
- Mercy Hospital
-
Scranton, Pennsylvania, United States, 18508
- Hematology and Oncology Associates of North East Pennsylvania
-
Sellersville, Pennsylvania, United States, 18960
- Grand View Hospital
-
State College, Pennsylvania, United States, 16801
- Geisinger Medical Group
-
Upland, Pennsylvania, United States, 19013
- Associates In Hematology Oncology PC-Upland
-
West Chester, Pennsylvania, United States, 19380
- Chester County Hospital
-
West Reading, Pennsylvania, United States, 19612
- Reading Hospital and Medical Center
-
Wilkes-Barre, Pennsylvania, United States, 18711
- Geisinger Wyoming Valley
-
Williamsport, Pennsylvania, United States, 17701
- Susquehanna Cancer Center
-
Wynnewood, Pennsylvania, United States, 19096
- Lankenau Hospital
-
Wynnewood, Pennsylvania, United States, 19096
- Mainline Health CCOP
-
York, Pennsylvania, United States, 17405
- York Hospital
-
-
Rhode Island
-
Providence, Rhode Island, United States, 02903
- Rhode Island Hospital
-
Providence, Rhode Island, United States, 02905
- Women and Infants Hospital
-
Providence, Rhode Island, United States, 02906
- Miriam Hospital
-
Warwick, Rhode Island, United States, 02886
- Kent County Hospital
-
-
South Carolina
-
Anderson, South Carolina, United States, 29621
- AnMed Health Cancer Center
-
Anderson, South Carolina, United States, 29621
- AnMed Health Hospital
-
Beaufort, South Carolina, United States, 29902
- Beaufort Memorial Hospital
-
Charleston, South Carolina, United States, 29425
- Medical University of South Carolina
-
Charleston, South Carolina, United States, 29401
- Roper Hospital
-
Florence, South Carolina, United States, 29506
- McLeod Regional Medical Center
-
Greenville, South Carolina, United States, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, United States, 29605
- Greenville Memorial Hospital
-
Greenville, South Carolina, United States, 29605
- Cancer Centers of the Carolinas - Grove Commons
-
Greenville, South Carolina, United States, 29605
- Cancer Centers of the Carolinas - Faris
-
Greenville, South Carolina, United States, 29615
- Greenville CCOP
-
Greenwood, South Carolina, United States, 29646
- Self Regional Healthcare
-
Greer, South Carolina, United States, 29651
- Gibbs Cancer Center-Pelham
-
Greer, South Carolina, United States, 29650
- Cancer Centers of the Carolinas-Greer Medical Oncology
-
Seneca, South Carolina, United States, 29672
- Cancer Centers of the Carolinas - Seneca
-
Spartanburg, South Carolina, United States, 29303
- Spartanburg Regional Medical Center
-
Spartanburg, South Carolina, United States, 29303
- Upstate Carolina CCOP
-
Spartanburg, South Carolina, United States, 29307
- Cancer Centers of the Carolinas - Spartanburg
-
-
South Dakota
-
Aberdeen, South Dakota, United States, 57401
- Conklin Regional Cancer Center
-
Rapid City, South Dakota, United States, 57701
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, United States, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, United States, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, United States, 57104
- Sanford Cancer Center-Oncology Clinic
-
-
Tennessee
-
Bristol, Tennessee, United States, 37620
- Wellmont Bristol Regional Medical Center
-
Bristol, Tennessee, United States, 37620
- Blue Ridge Medical Specialists PC
-
Chattanooga, Tennessee, United States, 37403
- Erlanger Medical Center
-
Kingsport, Tennessee, United States, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Knoxville, Tennessee, United States, 37916
- Thompson Cancer Survival Center
-
Knoxville, Tennessee, United States, 37920
- University of Tennessee - Knoxville
-
-
Texas
-
Abilene, Texas, United States, 79606
- Texas Cancer Center
-
Amarillo, Texas, United States, 79106
- Texas Oncology PA - Amarillo
-
Arlington, Texas, United States, 76014
- Texas Oncology-Arlington South
-
Beaumont, Texas, United States, 77702
- Texas Oncology PA Beaumont
-
Bedford, Texas, United States, 76022
- Texas Oncology PA - Bedford
-
Bryan, Texas, United States, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, United States, 75230
- Texas Cancer Center - Medical City Dallas
-
Dallas, Texas, United States, 75237
- Texas Oncology Methodist Charlton Cancer Center
-
Dallas, Texas, United States, 75231
- Texas Health Presbyterian Hospital Dallas
-
Dallas, Texas, United States, 75246
- Texas Oncology Pa
-
Denton, Texas, United States, 76210
- Texas Oncology-Denton South
-
El Paso, Texas, United States, 79915
- Texas Oncology-El Paso
-
Flower Mound, Texas, United States, 75028
- Texas Oncology-Flower Mound
-
Fort Worth, Texas, United States, 76104
- Texas Oncology Fort Worth at 12th Avenue
-
Garland, Texas, United States, 75042
- Texas Oncology - Garland
-
Houston, Texas, United States, 77030
- Baylor College of Medicine
-
Houston, Texas, United States, 77030
- Methodist Hospital
-
Houston, Texas, United States, 77024
- Memorial Hermann Memorial City Medical Center
-
Lewisville, Texas, United States, 75067
- Texas Oncology - Lewisville
-
Lubbock, Texas, United States, 79410
- Covenant Medical Center-Lakeside
-
Lubbock, Texas, United States, 79430
- Texas Tech University Health Sciences Center
-
McAllen, Texas, United States, 78503
- Texas Oncology-McAllen
-
Mesquite, Texas, United States, 75150
- Texas Cancer Center - Mesquite
-
Midland, Texas, United States, 79701
- Texas Oncology-Midland Allison Cancer Center
-
Paris, Texas, United States, 75460
- Texas Oncology-Paris
-
Plano, Texas, United States, 75075
- North Texas Regional Cancer Center
-
Round Rock, Texas, United States, 78681
- Texas Oncology - Round Rock Cancer Center
-
Round Rock, Texas, United States, 78665
- Scott and White Healthcare Round Rock
-
San Antonio, Texas, United States, 78229-3900
- University of Texas Health Science Center at San Antonio
-
San Antonio, Texas, United States, 78217
- Cancer Care Centers of South Texas- Northeast
-
Sherman, Texas, United States, 75090
- Texas Cancer Center-Sherman
-
Temple, Texas, United States, 76508
- Scott and White Memorial Hospital
-
The Woodlands, Texas, United States, 77380
- US Oncology Research LLC-The Woodlands
-
Tyler, Texas, United States, 75702
- Tyler Cancer Center
-
Waco, Texas, United States, 76712
- Texas Oncology Pa
-
-
Utah
-
American Fork, Utah, United States, 84003
- American Fork Hospital
-
Cedar City, Utah, United States, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, United States, 84321
- Logan Regional Hospital
-
Murray, Utah, United States, 84157
- Intermountain Medical Center
-
Ogden, Utah, United States, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, United States, 84604-3337
- Utah Valley Regional Medical Center
-
Saint George, Utah, United States, 84770
- Dixie Medical Center Regional Cancer Center
-
Salt Lake City, Utah, United States, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, United States, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, United States, 84143
- LDS Hospital
-
-
Vermont
-
Berlin, Vermont, United States, 05602
- Mountainview Medical
-
Burlington, Vermont, United States, 05401
- University of Vermont
-
Rutland, Vermont, United States, 05701
- Rutland Regional Medical Center
-
-
Virginia
-
Burke, Virginia, United States, 22015
- Kaiser Permanente-Burke Medical Center
-
Charlottesville, Virginia, United States, 22908
- University of Virginia
-
Fairfax, Virginia, United States, 22033
- Kaiser Permanente - Fair Oaks Medical Center
-
Fairfax, Virginia, United States, 22031
- Virginia Cancer Specialists-Fairfax
-
Fredericksburg, Virginia, United States, 22401
- Fredericksburg Oncology Inc
-
Fredericksburg, Virginia, United States, 22408
- Hematology Oncology Associates of Fredericksburg Inc
-
Gloucester, Virginia, United States, 23061
- Peninsula Cancer Institute-Gloucester
-
Hampton, Virginia, United States, 23666
- Virginia Oncology Associates-Hampton
-
McLean, Virginia, United States, 22102
- Kaiser Permanente Tysons Corner Medical Center
-
Newport News, Virginia, United States, 23601
- Peninsula Cancer Institute-Newport News
-
Norton, Virginia, United States, 24273
- Southwest VA Regional Cancer Center
-
Richmond, Virginia, United States, 23298
- Virginia Commonwealth University
-
Roanoke, Virginia, United States, 24014
- Oncology and Hematology Associates of Southwest Virginia
-
South Hill, Virginia, United States, 23970
- Community Memorial Health Center
-
Virginia Beach, Virginia, United States, 23454
- Peninsula Cancer Institute-Cancer Specialists of Tidewater
-
Williamsburg, Virginia, United States, 23185
- Peninsula Cancer Institute-Williamsburg
-
Winchester, Virginia, United States, 22601
- Shenandoah Oncology Associates PC
-
-
Washington
-
Anacortes, Washington, United States, 98221
- Cancer Care Center at Island Hospital
-
Auburn, Washington, United States, 98002
- Auburn Regional Medical Center
-
Bellevue, Washington, United States, 98004
- Overlake Hospital Medical Center
-
Bellingham, Washington, United States, 98225
- PeaceHealth Saint Joseph Medical Center
-
Bremerton, Washington, United States, 98310
- Harrison Medical Center
-
Bremerton, Washington, United States, 98310
- Harrison Bremerton Hematology and Oncology
-
Burien, Washington, United States, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, United States, 98531
- Providence Centralia Hospital
-
Edmonds, Washington, United States, 98026
- Swedish Medical Center-Edmonds
-
Edmonds, Washington, United States, 98026
- Puget Sound Cancer Center
-
Everett, Washington, United States, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, United States, 98003
- Saint Francis Hospital
-
Issaquah, Washington, United States, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, United States, 99336
- Columbia Basin Hematology and Oncology PLLC
-
Kirkland, Washington, United States, 98034
- Cascade Cancer Center
-
Mount Vernon, Washington, United States, 98274
- Skagit Valley Hospital
-
Mount Vernon, Washington, United States, 98274
- Skagit Valley Hospital Regional Cancer Care Center
-
Olympia, Washington, United States, 98506-5166
- Providence - Saint Peter Hospital
-
Poulsbo, Washington, United States, 98370
- Harrison Poulsbo Hematology and Oncology
-
Puyallup, Washington, United States, 98372
- Good Samaritan Community Hospital
-
Seattle, Washington, United States, 98195
- University of Washington Medical Center
-
Seattle, Washington, United States, 98109
- Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
-
Seattle, Washington, United States, 98104
- Harborview Medical Center
-
Seattle, Washington, United States, 98104
- Minor and James Medical PLLC
-
Seattle, Washington, United States, 98122-4307
- Swedish Medical Center-First Hill
-
Seattle, Washington, United States, 98112
- Group Health Cooperative
-
Seattle, Washington, United States, 98109
- Group Health
-
Sedro-Woolley, Washington, United States, 98284
- United General Hospital
-
Sequim, Washington, United States, 98384
- Olympic Medical Cancer Care Center
-
Spokane, Washington, United States, 99218
- Evergreen Hematology and Oncology PS
-
Spokane, Washington, United States, 99202
- Cancer Care Northwest - Spokane South
-
Spokane, Washington, United States, 99220
- Rockwood Clinic
-
Spokane, Washington, United States, 99218
- Cancer Care Northwest
-
Spokane, Washington, United States, 99204
- Rockwood Cancer Treatment Center
-
Tacoma, Washington, United States, 98405
- Saint Joseph Medical Center
-
Tacoma, Washington, United States, 98405
- Allenmore Hospital
-
Tacoma, Washington, United States, 98415
- Multicare Health System
-
Tacoma, Washington, United States, 98405
- Northwest CCOP
-
Tacoma, Washington, United States, 98499
- Saint Clare Hospital
-
Vancouver, Washington, United States, 98684
- Northwest Cancer Specialists
-
Vancouver, Washington, United States, 98686
- Legacy Salmon Creek Hospital
-
Vancouver, Washington, United States, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, United States, 99362
- Providence Saint Mary Regional Cancer Center
-
Wenatchee, Washington, United States, 98801
- Wenatchee Valley Medical Center
-
Yakima, Washington, United States, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
-
West Virginia
-
Charleston, West Virginia, United States, 25304
- West Virginia University Charleston
-
Huntington, West Virginia, United States, 25701
- Edwards Comprehensive Cancer Center
-
Martinsburg, West Virginia, United States, 25401
- City Hospital
-
Morgantown, West Virginia, United States, 26506
- West Virginia University
-
Princeton, West Virginia, United States, 24740
- Princeton Community Hospital
-
Wheeling, West Virginia, United States, 26003
- Wheeling Hospital
-
-
Wisconsin
-
Antigo, Wisconsin, United States, 54409
- Langlade Hospital and Cancer Center
-
Appleton, Wisconsin, United States, 54911-3496
- Fox Valley Hematology and Oncology
-
Chippewa Falls, Wisconsin, United States, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, United States, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Eau Claire, Wisconsin, United States, 54702
- Midelfort Clinic-Clairemont Campus
-
Eau Claire, Wisconsin, United States, 54703
- Mayo Clinic Health System Eau Claire Hospital - Luther Campus
-
Green Bay, Wisconsin, United States, 54301
- Bellin Memorial Hospital
-
Green Bay, Wisconsin, United States, 54301
- Saint Vincent Hospital
-
Green Bay, Wisconsin, United States, 54303
- Green Bay Oncology Limited at Saint Mary's Hospital
-
Green Bay, Wisconsin, United States, 54303
- Saint Mary's Hospital
-
Green Bay, Wisconsin, United States, 54301-3526
- Green Bay Oncology at Saint Vincent Hospital
-
Green Bay, Wisconsin, United States, 54311-6519
- Aurora BayCare Medical Center
-
Janesville, Wisconsin, United States, 53547
- Mercy Health System
-
Johnson Creek, Wisconsin, United States, 53038
- UW Cancer Center Johnson Creek
-
La Crosse, Wisconsin, United States, 54601
- Mayo Clinic Health System-Franciscan Healthcare
-
La Crosse, Wisconsin, United States, 54601
- Gundersen Lutheran
-
Madison, Wisconsin, United States, 53792
- University of Wisconsin Hospital and Clinics
-
Madison, Wisconsin, United States, 53717
- Dean Hematology and Oncology Clinic
-
Manitowoc, Wisconsin, United States, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, United States, 54143
- Bay Area Medical Center
-
Marinette, Wisconsin, United States, 54143
- Vince Lombardi Cancer Clinic-Marinette
-
Marshfield, Wisconsin, United States, 54449
- Marshfield Clinic
-
Milwaukee, Wisconsin, United States, 53226
- Froedtert and the Medical College of Wisconsin
-
Minocqua, Wisconsin, United States, 54548
- Marshfield Clinic-Minocqua Center
-
Mukwonago, Wisconsin, United States, 53149
- D N Greenwald Center
-
New Richmond, Wisconsin, United States, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, United States, 53066-3896
- Oconomowoc Memorial Hospital-ProHealth Care Inc
-
Oconto Falls, Wisconsin, United States, 54154
- Green Bay Oncology - Oconto Falls
-
Oshkosh, Wisconsin, United States, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Rhinelander, Wisconsin, United States, 54501
- Marshfield Clinic at James Beck Cancer Center
-
Rice Lake, Wisconsin, United States, 54868
- Marshfield Clinic-Rice Lake Center
-
Sheboygan, Wisconsin, United States, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, United States, 53081
- Saint Nicholas Hospital
-
Stevens Point, Wisconsin, United States, 54481
- Marshfield Clinic Cancer Care at Saint Michael's Hospital
-
Sturgeon Bay, Wisconsin, United States, 54235
- Green Bay Oncology - Sturgeon Bay
-
Summit, Wisconsin, United States, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, United States, 54241
- Vince Lombardi Cancer Clinic
-
Waukesha, Wisconsin, United States, 53188
- Waukesha Memorial Hospital - ProHealth Care
-
Wausau, Wisconsin, United States, 54401
- Aspirus Regional Cancer Center
-
Wausau, Wisconsin, United States, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, United States, 53226
- Aurora Cancer Care-Milwaukee West
-
Weston, Wisconsin, United States, 54476
- Marshfield Clinic - Weston Center
-
Wisconsin Rapids, Wisconsin, United States, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
Wisconsin Rapids, Wisconsin, United States, 54494
- Riverview Hospital
-
-
Wyoming
-
Casper, Wyoming, United States, 82609
- Rocky Mountain Oncology
-
Sheridan, Wyoming, United States, 82801
- Welch Cancer Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Female
Description
Inclusion Criteria:
- The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
- The tumor must be unilateral invasive adenocarcinoma of the breast on histologic examination.
- The breast cancer must be Human Epidermal Growth Factor Receptor 2 (HER2)-negative based on current American Society of Clinical Oncology (ASCO)/CAP Guideline Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer. If the result of the in situ hybridization testing (FISH, chromagen in situ hybridization [CISH], or other) is equivocal, the patient is eligible if there is no plan to administer HER2-targeted therapy.
All of the following staging criteria must be met according to American Joint Committee on Cancer (AJCC) criteria:
- By pathologic evaluation, primary tumor must be pT1-3;
- By pathologic evaluation, ipsilateral nodes must be pN0, pN1 (pN1mi, pN1a, pN1b, pN1c), pN2a, pN3a, or pN3b.
- If pN0, at least one of the following criteria must be met:
- ER negative and PgR negative; or
- Pathologic tumor size greater than 2.0 cm; or
- T1c (pathologic tumor size greater than 1.0 cm but less than or equal to 2.0 cm) and ER positive (PgR status may be positive or negative) and either grade 3 histology or Oncotype DX® Recurrence Score of greater than or equal to 25.
- Patients must have undergone either a total mastectomy or breast-conserving surgery (lumpectomy).
- For patients who undergo lumpectomy, the margins of the resected specimen must be histologically free of invasive tumor and ductal carcinoma in situ (DCIS) as determined by the local pathologist. If pathologic examination demonstrates tumor at the line of resection, additional operative procedures must be performed to obtain clear margins. If tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible. (Patients with margins positive for lobular carcinoma in situ [LCIS] are eligible without additional resection.)
- For patients who undergo mastectomy, margins must be histologically free of invasive tumor and DCIS.
Patients must have completed one of the following procedures for evaluation of pathologic nodal status:
- Sentinel lymphadenectomy alone if pathologic nodal staging based on sentinel lymphadenectomy is pN0, pN1mi, or pN1b;
- Sentinel lymphadenectomy alone if pathologic nodal staging based on sentinel lymphadenectomy is pN1a limited to 1 or 2 positive nodes and primary tumor is T1 or T2 by pathologic evaluation;
- Sentinel lymphadenectomy followed by removal of additional non-sentinel lymph nodes if the sentinel node (SN) is positive; or
- Axillary lymphadenectomy with or without SN isolation procedure.
- The interval between the last surgery for breast cancer (treatment or staging) and randomization must be no more than 84 days.
- Patients must have ER analysis performed on the primary tumor prior to randomization. Breast cancer must be assessed for ER status by current ASCO/CAP Guideline Recommendations for hormone receptor testing. If negative for ER, assessment of PgR must also be performed according to current ASCO/CAP Guideline Recommendations for hormone receptor testing. (Either a core biopsy or surgical resection specimen can be used for ER/PgR testing.)
The most recent postoperative blood counts, performed within 6 weeks prior to randomization, must meet the following criteria:
- absolute neutrophil count (ANC) must be greater than or equal to 1200/mm3;
- platelet count must be greater than or equal to 100,000/mm3; and
- hemoglobin must be greater than or equal to 10 g/dL.
The following criteria for evidence of adequate hepatic function must be met based on the results of the most recent postoperative tests performed within 6 weeks prior to randomization:
- total bilirubin must be less than or equal to upper limit of normal (ULN) for the lab unless the patient has a bilirubin elevation greater than ULN to 1.5 x ULN due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin; and
- alkaline phosphatase must be less than or equal to 2.5 x ULN for the lab; and
- aspartate transaminase (AST) must be less than or equal to 1.5 x ULN for the lab.
- Alkaline phosphatase and AST may not both be greater than the ULN. For example, if the alkaline phosphatase is greater than the ULN but less than or equal to 2.5 x ULN, then the AST must be less than or equal to the ULN. If the AST is greater than the ULN but less than or equal to 1.5 x ULN, then the alkaline phosphatase must be less than or equal to ULN.
- Note: If alanine aminotransferase (ALT) is performed instead of AST (per institution's standard practice), the ALT value must be less than or equal to 1.5 x ULN; if both were performed, the AST must be less than or equal to 1.5 x ULN.
- Patients with AST or alkaline phosphatase greater than ULN are eligible for inclusion in the study if liver imaging (CT, MRI, PET-CT, or PET scan performed within 90 days prior to randomization) does not demonstrate metastatic disease and the requirements for adequate hepatic function as described above are met.
- Patients with alkaline phosphatase that is greater than ULN but less than or equal to 2.5 x ULN are eligible for inclusion in the study if a bone scan, PET-CT scan, or PET scan performed within 90 days prior to randomization does not demonstrate metastatic disease.
- The most recent postoperative serum creatinine performed within 6 weeks prior to randomization must be less than or equal to ULN for the lab.
- Left ventricular ejection fraction (LVEF) assessment by 2-D echocardiogram or multigated acquisition (MUGA) scan must be performed within 90 days prior to randomization. The LVEF must be greater than or equal to 50% regardless of the facility's lower limit of normal (LLN). (If the facility performing the assessment has not reported the LVEF as a whole number, decimals reported as greater than or equal to 5 should be rounded up and decimals reported as less than 5 should be rounded down.)
Exclusion criteria:
Patients with one or more of the following conditions are ineligible for this study.
- T4 tumors including inflammatory breast cancer.
- Definitive clinical or radiologic evidence of metastatic disease. (Chest imaging [mandatory for all patients] and other imaging [if required] must have been performed within 90 days prior to randomization.)
- Synchronous or previous contralateral invasive breast cancer. (Patients with synchronous and/or previous contralateral DCIS are eligible.)
- Any history of ipsilateral invasive breast cancer or ipsilateral DCIS.
- History of non-breast malignancies within 5 years prior to randomization, except for the following: carcinoma in situ of the cervix, colorectal carcinoma in situ, melanoma in situ, and basal cell and squamous cell carcinomas of the skin.
- Previous therapy with anthracyclines or taxanes for any malignancy.
- Chemotherapy administered for the currently diagnosed breast cancer prior to randomization.
- Continued endocrine therapy such as raloxifene or tamoxifen (or other SERM) or an aromatase inhibitor. Patients are eligible if these medications are discontinued prior to randomization.
- Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy. Patients are eligible if these medications are discontinued prior to randomization.
- Known active hepatitis B or hepatitis C with abnormal liver function tests.
Cardiac disease (history of and/or active disease) that would preclude the use of the drugs included in the treatment regimens. This includes but is not confined to:
- Active cardiac disease
- angina pectoris that requires the use of anti-anginal medication;
- ventricular arrhythmias except for benign premature ventricular contractions;
- supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication;
- conduction abnormality requiring a pacemaker;
- valvular disease with documented compromise in cardiac function;
- symptomatic pericarditis.
- History of cardiac disease
- myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricular function;
- history of documented congestive heart failure (CHF);
- documented cardiomyopathy.
- Whole breast radiation therapy (RT) prior to randomization or partial breast RT that cannot be completed on or before the date of randomization.
- Intrinsic lung disease resulting in dyspnea.
- Unstable diabetes mellitus.
- Active infection or chronic infection requiring suppressive antibiotics.
- History of a major organ allograft or condition requiring chronic immunosuppression, e.g., kidney, liver, lung, heart, bone marrow transplant, or autoimmune diseases. (Patients who have received corneal transplants, cadaver skin, or bone transplants are eligible.)
- Nervous system disorder (paresthesia, peripheral motor neuropathy, or peripheral sensory neuropathy) greater than or equal to grade 2, per the NCI CTCAE v4.0.
- Conditions that would prohibit administration of corticosteroids.
- Chronic daily treatment with corticosteroids (dose of greater than or equal to 10 mg/day methylprednisolone equivalent) (excluding inhaled steroids).
- History of hypersensitivity reaction to drugs formulated with polysorbate 80.
- Pregnancy or lactation at the time of study entry. (Note: Pregnancy testing must be performed within 2 weeks prior to randomization according to institutional standards for women of childbearing potential.)
- Other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up.
- Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements.
- Use of any investigational product within 30 days prior to randomization.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Active Comparator: Arm 1: Anthracycline-based chemotherapy
4 anthracycline-based chemotherapy regimens (Regimens A, B, C, or D). Regimen A (TAC): 75 mg/m2 docetaxel (T) + 50 mg/m2 doxorubicin (A) + 500 mg/m2 cyclophosphamide (C) IV every 3 weeks for 6 cycles. Regimen B (AC then WP): 60 mg/m2 doxorubicin (A) + 600 mg/m2 cyclophosphamide (C) every 3 weeks for 4 cycles followed by weekly paclitaxel (WP) 80 mg/m2 IV every week for 12 doses. Regimen C (DD AC then WP): 60 mg/m2 doxorubicin + 600 mg/m2 cyclophosphamide every 2 weeks for 4 cycles followed by weekly paclitaxel 80 mg/m2 IV every week for 12 doses. Regimen D (DD AC then DD P): 60 mg/m2 doxorubicin + 600 mg/m2 cyclophosphamide every 2 weeks for 4 cycles followed by paclitaxel (P) 175 mg/m2 IV every 2 weeks for 4 cycles. |
Other Names:
|
|
Active Comparator: Arm 2: docetaxel + cyclophosphamide
TC: 75 mg/m2 docetaxel and 600 mg/m2 cyclophosphamide IV every 3 weeks for 6 cycles
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Invasive disease-free survival (IDFS)
Time Frame: Assessed before each cycle of chemotherapy, 3-4 weeks after completion of chemotherapy, every 6 months through 5 years and yearly years 6-10.
|
The time to local recurrence following mastectomy, invasive local recurrence in the ipsilateral breast following lumpectomy, regional recurrence, distant recurrence, invasive contralateral breast cancer, second primary cancer (other than squamous or basal cell carcinoma of the skin, melanoma in situ, carcinoma in situ of the cervix, colorectal carcinoma in situ, or lobular carcinoma in situ of the breast), or death from any cause prior to recurrence or second primary cancer.
|
Assessed before each cycle of chemotherapy, 3-4 weeks after completion of chemotherapy, every 6 months through 5 years and yearly years 6-10.
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Disease-free survival (DFS-DCIS)
Time Frame: Assessed before each cycle of chemotherapy, 3-4 weeks after completion of chemotherapy, every 6 months through 5 years and yearly years 6-10.
|
The time to local recurrence following mastectomy, local recurrence in the ipsilateral breast following lumpectomy (invasive or non-invasive), regional recurrence, distant recurrence, contralateral breast cancer (invasive or non-invasive), second primary cancer (other than squamous or basal cell carcinoma of the skin, melanoma in situ, carcinoma in situ of the cervix, colorectal carcinoma in situ, or lobular carcinoma in situ of the breast), or death from any cause prior to recurrence or second primary cancer.
|
Assessed before each cycle of chemotherapy, 3-4 weeks after completion of chemotherapy, every 6 months through 5 years and yearly years 6-10.
|
|
Overall survival (OS)
Time Frame: Assessed before each cycle of chemotherapy, 3-4 weeks after completion of chemotherapy, every 6 months through 5 years and yearly years 6-10.
|
Time from randomization until death from any cause.
|
Assessed before each cycle of chemotherapy, 3-4 weeks after completion of chemotherapy, every 6 months through 5 years and yearly years 6-10.
|
|
Recurrence-free interval (RFI)
Time Frame: Assessed before each cycle of chemotherapy, 3-4 weeks after completion of chemotherapy, every 6 months through 5 years and yearly years 6-10.
|
Time from randomization until local, regional, or distant recurrence.
|
Assessed before each cycle of chemotherapy, 3-4 weeks after completion of chemotherapy, every 6 months through 5 years and yearly years 6-10.
|
|
Toxicity of each regimen
Time Frame: Assessed before each cycle of chemotherapy, 3-4 weeks after completion of chemotherapy, every 6 months through 5 years and yearly years 6-10.
|
Frequencies of adverse events categorized using the NCI Common Terminology Criteria for Adverse Events (CTCAE) v4.0.
|
Assessed before each cycle of chemotherapy, 3-4 weeks after completion of chemotherapy, every 6 months through 5 years and yearly years 6-10.
|
|
Molecular predictors of efficacy
Time Frame: Tissue sample collected at time of surgery
|
To develop predictive markers for benefit from doxorubicin.
|
Tissue sample collected at time of surgery
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
April 1, 2012
Primary Completion (Anticipated)
May 1, 2022
Study Completion (Anticipated)
November 1, 2023
Study Registration Dates
First Submitted
March 6, 2012
First Submitted That Met QC Criteria
March 6, 2012
First Posted (Estimate)
March 8, 2012
Study Record Updates
Last Update Posted (Actual)
April 14, 2022
Last Update Submitted That Met QC Criteria
April 13, 2022
Last Verified
April 1, 2022
More Information
Terms related to this study
Keywords
- stage IIIA breast cancer
- stage II breast cancer
- stage IIIC breast cancer
- stage IA breast cancer
- stage IB breast cancer
- estrogen receptor-negative breast cancer
- estrogen receptor-positive breast cancer
- progesterone receptor-negative breast cancer
- progesterone receptor-positive breast cancer
- HER2-negative breast cancer
Additional Relevant MeSH Terms
- Skin Diseases
- Neoplasms
- Neoplasms by Site
- Breast Diseases
- Breast Neoplasms
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Enzyme Inhibitors
- Antirheumatic Agents
- Antineoplastic Agents
- Immunosuppressive Agents
- Immunologic Factors
- Tubulin Modulators
- Antimitotic Agents
- Mitosis Modulators
- Antineoplastic Agents, Alkylating
- Alkylating Agents
- Myeloablative Agonists
- Antineoplastic Agents, Phytogenic
- Topoisomerase II Inhibitors
- Topoisomerase Inhibitors
- Antibiotics, Antineoplastic
- Docetaxel
- Cyclophosphamide
- Paclitaxel
- Doxorubicin
Other Study ID Numbers
- NSABP-B-49
- NCI-2012-00701 (Registry Identifier: CTRP (Clinical Trials Reporting Program))
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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