Docetaxel og cyclophosphamid sammenlignet med antracyklin-baseret kemoterapi til behandling af kvinder med HER2-negativ brystkræft
13. april 2022 opdateret af: NSABP Foundation Inc
Et klinisk fase III-forsøg, der sammenligner kombinationen af docetaxel plus cyclophosphamid med antracyklin-baserede kemoterapiregimer til kvinder med knudepositiv eller højrisikoknude-negativ, HER2-negativ brystkræft
RATIONALE: Lægemidler, der bruges i kemoterapi, virker på forskellige måder for at stoppe væksten af brystkræftceller, enten ved at dræbe cellerne eller ved at forhindre dem i at dele sig. At give stofferne i forskellige kombinationer kan dræbe flere brystkræftceller. At give kombinationskemoterapi efter operationen kan dræbe eventuelle tumorceller, der er tilbage efter operationen.
FORMÅL: Dette randomiserede fase III-forsøg studerer forskellige kombinationskemoterapiregimer og deres bivirkninger og sammenligner, hvor godt de virker ved behandling af kvinder med ikke-metastatisk brystkræft.
Studieoversigt
Status
Aktiv, ikke rekrutterende
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
MÅL:
Primær
- For at bestemme, om docetaxel- og cyclophosphamid (TC)-regimet er ikke-underlegent i forhold til de antracyklin-baserede kemoterapi-regimer med hensyn til invasiv sygdomsfri overlevelse (DFS) ved at kombinere B-49-data med docetaxel, doxorubicin og cyclophosphamid (TAC) og TC-arme af NSABP B-46-I/US Oncology Research, Inc.(USOR) 07132 og dataene fra USOR 06-090.
Sekundær
- For at bestemme frekvensen af DFS-duktalt karcinom in situ (DCIS) for TC- og antracyklin-baserede kemoterapiregimer.
- For at bestemme rater for samlet overlevelse (OS) for TC- og antracyklin-baserede kemoterapiregimer.
- For at bestemme frekvensen af gentagelsesfrit interval (RFI) for TC- og antracyklin-baserede kemoterapiregimer.
- At evaluere toksiciteten forbundet med hver af regimerne.
- At bestemme TOP2A's rolle i prognose og forudsigelse af graden af fordel ved antracyklin-baseret kemoterapi i forhold til TC. (udforskende)
- At udvikle prædiktive markører for gavn af doxorubicin. (udforskende)
OVERSIGT: Dette er en randomiseret multicenterundersøgelse. Patienterne stratificeres efter antallet af positive noder (0 vs 1-3 vs 4-9 vs 10+) og hormon-receptor status (østrogenreceptor [ER] og/eller progesteronreceptor [PgR] positiv vs ER og PgR negativ). Patienterne randomiseres til 1 ud af 2 behandlingsarme.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
1871
Fase
- Fase 3
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Alaska
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Anchorage, Alaska, Forenede Stater, 99508
- Providence Alaska Medical Center
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Arizona
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Phoenix, Arizona, Forenede Stater, 85016
- Arizona Oncology Associates-Biltmore Cancer Center
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Scottsdale, Arizona, Forenede Stater, 85258
- Premiere Oncology of Arizona
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Sedona, Arizona, Forenede Stater, 86336
- Sedona Medical Center
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Tucson, Arizona, Forenede Stater, 85704
- Arizona Oncology Associates
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Arkansas
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Jonesboro, Arkansas, Forenede Stater, 72401
- NEA Baptist Clinic-Matthews
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California
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Anaheim, California, Forenede Stater, 92807
- Kaiser Anaheim Medical Center
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Antioch, California, Forenede Stater, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Baldwin Park, California, Forenede Stater, 91706
- Kaiser Permanente Medical Group - Baldwin Park
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Bellflower, California, Forenede Stater, 90706
- Kaiser Foundation Hospital
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Burbank, California, Forenede Stater, 91505
- Providence Saint Joseph Medical Center
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Castro Valley, California, Forenede Stater, 94546
- East Bay Radiation Oncology Center
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Castro Valley, California, Forenede Stater, 94546
- Valley Medical Oncology Consultants-Castro Valley
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Dublin, California, Forenede Stater, 94568
- Epic Care-Dublin
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Fairfield, California, Forenede Stater, 94533
- Northbay Cancer Center
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Fontana, California, Forenede Stater, 92335
- Kaiser Permanente Hospital
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Fremont, California, Forenede Stater, 94538
- Valley Medical Oncology Consultants-Fremont
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Fremont, California, Forenede Stater, 94538
- Washington Hospital
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Fremont, California, Forenede Stater, 94538
- Kaiser Permanente, Fremont
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Fresno, California, Forenede Stater, 93720
- Kaiser Permanente
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Fresno, California, Forenede Stater, 93720
- California Cancer Center - North Fresno
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Harbor City, California, Forenede Stater, 90710
- Kaiser Permanente - Harbor City
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Hayward, California, Forenede Stater, 94545
- Kaiser Permanente, Hayward
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Irvine, California, Forenede Stater, 92618
- Southern California Permanente Medical Group
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La Jolla, California, Forenede Stater, 92093
- UC San Diego Moores Cancer Center
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Long Beach, California, Forenede Stater, 90806
- Long Beach Memorial Medical Center-Todd Cancer Institute
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Los Angeles, California, Forenede Stater, 90048
- Cedars-Sinai Medical Center
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Los Angeles, California, Forenede Stater, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, Forenede Stater, 90027
- Kaiser Permanente
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Los Angeles, California, Forenede Stater, 90034
- Kaiser Permanente-West Los Angeles
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Martinez, California, Forenede Stater, 94553-3156
- Contra Costa Regional Medical Center
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Modesto, California, Forenede Stater, 95355
- Memorial Medical Center
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Modesto, California, Forenede Stater, 95356
- Kaiser Permanente-Modesto
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Monterey, California, Forenede Stater, 93940
- Community Hospital of Monterey Peninsula
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Mountain View, California, Forenede Stater, 94040
- El Camino Hospital
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Oakland, California, Forenede Stater, 94611
- Kaiser Permanente-Oakland
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Oakland, California, Forenede Stater, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, Forenede Stater, 94602
- Highland General Hospital
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Oakland, California, Forenede Stater, 94609
- Bay Area Breast Surgeons Inc
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Oakland, California, Forenede Stater, 94609
- Larry G Strieff MD Medical Corporation
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Oakland, California, Forenede Stater, 94609
- Tom K Lee Inc
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Oakland, California, Forenede Stater, 94609
- Bay Area Tumor Institute
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Oakland, California, Forenede Stater, 94612
- Epic Care-Oakland
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Palm Springs, California, Forenede Stater, 92262
- Desert Regional Medical Center
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Panorama City, California, Forenede Stater, 91402
- Kaiser Permanente - Panorama City
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Paradise, California, Forenede Stater, 95969
- Feather River Cancer Center
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Pleasant Hill, California, Forenede Stater, 94523
- East Bay Medical Oncology Hematology Medical Associates Inc-Pleasant Hill
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Pomona, California, Forenede Stater, 91767
- Pomona Valley Hospital Medical Center
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Redwood City, California, Forenede Stater, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, Forenede Stater, 94801
- Kaiser Permanente-Richmond
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Riverside, California, Forenede Stater, 92505
- Kaiser Permanente Medical Center
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Roseville, California, Forenede Stater, 95661
- Kaiser Permanente-Roseville
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Sacramento, California, Forenede Stater, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, Forenede Stater, 95825
- Kaiser Permanente - Sacramento
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Saint Helena, California, Forenede Stater, 94574
- Saint Helena Hospital
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San Diego, California, Forenede Stater, 92134
- Naval Medical Center -San Diego
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San Diego, California, Forenede Stater, 92120
- Kaiser Permanente at San Diego
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San Francisco, California, Forenede Stater, 94115
- Kaiser Permanente-San Francisco
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San Jose, California, Forenede Stater, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Jose, California, Forenede Stater, 95128
- Santa Clara Valley Medical Center
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San Marcos, California, Forenede Stater, 92069
- Kaiser Permanente Health Care
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San Pablo, California, Forenede Stater, 94806
- Doctors Medical Center- JC Robinson Regional Cancer Center
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San Rafael, California, Forenede Stater, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, Forenede Stater, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Rosa, California, Forenede Stater, 95403
- Kaiser Permanente-Santa Rosa
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South San Francisco, California, Forenede Stater, 94080
- Kaiser Permanente-South San Francisco
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Stanford, California, Forenede Stater, 94305
- Stanford University Hospitals and Clinics
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Stockton, California, Forenede Stater, 95210
- Kaiser Permanente-Stockton
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Vacaville, California, Forenede Stater, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, Forenede Stater, 94589
- Kaiser Permanente-Vallejo
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Walnut Creek, California, Forenede Stater, 94596
- Kaiser Permanente-Walnut Creek
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Whittier, California, Forenede Stater, 90602
- Presbyterian Intercommunity Hospital
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Woodland Hills, California, Forenede Stater, 91367
- Kaiser Permanente
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Colorado
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Aurora, Colorado, Forenede Stater, 80012
- The Medical Center of Aurora
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Boulder, Colorado, Forenede Stater, 80301
- Boulder Community Hospital
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Colorado Springs, Colorado, Forenede Stater, 80907
- Penrose-Saint Francis Healthcare
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Denver, Colorado, Forenede Stater, 80210
- Porter Adventist Hospital
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Denver, Colorado, Forenede Stater, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, Forenede Stater, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Forenede Stater, 80220
- Rose Medical Center
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Denver, Colorado, Forenede Stater, 80218
- Exempla Saint Joseph Hospital
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Denver, Colorado, Forenede Stater, 80224-2522
- Colorado Cancer Research Program CCOP
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Denver, Colorado, Forenede Stater, 80204
- Saint Anthony Central Hospital
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Englewood, Colorado, Forenede Stater, 80110
- Swedish Medical Center
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Fort Collins, Colorado, Forenede Stater, 80524
- Poudre Valley Hospital
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Fort Collins, Colorado, Forenede Stater, 80528
- Front Range Cancer Specialists
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Greeley, Colorado, Forenede Stater, 80631
- North Colorado Medical Center
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Lafayette, Colorado, Forenede Stater, 80026
- Kaiser Permanente-Rock Creek
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Littleton, Colorado, Forenede Stater, 80122
- Littleton Adventist Hospital
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Lone Tree, Colorado, Forenede Stater, 80124
- Sky Ridge Medical Center
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Longmont, Colorado, Forenede Stater, 80501
- Longmont United Hospital
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Loveland, Colorado, Forenede Stater, 80539
- McKee Medical Center
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Parker, Colorado, Forenede Stater, 80138
- Parker Adventist Hospital
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Pueblo, Colorado, Forenede Stater, 81004
- Saint Mary Corwin Medical Center
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Thornton, Colorado, Forenede Stater, 80229
- North Suburban Medical Center
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Wheat Ridge, Colorado, Forenede Stater, 80033
- Exempla Lutheran Medical Center
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Connecticut
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Farmington, Connecticut, Forenede Stater, 06030
- University of Connecticut
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Hartford, Connecticut, Forenede Stater, 06102
- Hartford Hospital
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Hartford, Connecticut, Forenede Stater, 06105
- Saint Francis Hospital and Medical Center
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Manchester, Connecticut, Forenede Stater, 06040
- Manchester Memorial Hospital
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Meriden, Connecticut, Forenede Stater, 06451
- Midstate Medical Center
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Middletown, Connecticut, Forenede Stater, 06457
- Middlesex Hospital
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New Britain, Connecticut, Forenede Stater, 06050
- The Hospital of Central Connecticut
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Stamford, Connecticut, Forenede Stater, 06904
- Stamford Hospital
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Delaware
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Dover, Delaware, Forenede Stater, 19901
- Bayhealth Medical Center at Kent General
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Lewes, Delaware, Forenede Stater, 19958
- Beebe Medical Center
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Newark, Delaware, Forenede Stater, 19718
- Christiana Care Health System-Christiana Hospital
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Seaford, Delaware, Forenede Stater, 19973
- Nanticoke Memorial Hospital
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District of Columbia
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Washington, District of Columbia, Forenede Stater, 20010
- Washington Hospital Center
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Washington, District of Columbia, Forenede Stater, 20057
- Lombardi Comprehensive Cancer Center at Georgetown University
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Washington, District of Columbia, Forenede Stater, 20016
- Sibley Memorial Hospital
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Washington, District of Columbia, Forenede Stater, 20002
- Kaiser Permanente-Capitol Hill Medical Center
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Washington, District of Columbia, Forenede Stater, 20037
- George Washington University Medical Center
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Florida
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Clearwater, Florida, Forenede Stater, 33756
- Morton Plant Hospital
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Fort Lauderdale, Florida, Forenede Stater, 33316
- Broward Health Medical Center
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Fort Lauderdale, Florida, Forenede Stater, 33308
- Holy Cross Hospital
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Jacksonville, Florida, Forenede Stater, 32207
- Edna Williams Cancer Center at the Baptist Cancer Institute
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Jacksonville, Florida, Forenede Stater, 32204
- Saint Vincent's Medical Center
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Jupiter, Florida, Forenede Stater, 33458
- Jupiter Medical Center
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Lakeland, Florida, Forenede Stater, 33805
- Lakeland Regional Cancer Center
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Lakeland, Florida, Forenede Stater, 33805
- The Watson Clinic
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Miami, Florida, Forenede Stater, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Miami, Florida, Forenede Stater, 33176
- Advanced Medical Specialties -North
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Miami Beach, Florida, Forenede Stater, 33140
- Mount Sinai Medical Center CCOP
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Ocala, Florida, Forenede Stater, 34471
- Ocala Oncology Center
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Orlando, Florida, Forenede Stater, 32803
- Florida Hospital
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Orlando, Florida, Forenede Stater, 32806
- M D Anderson Cancer Center- Orlando
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Pensacola, Florida, Forenede Stater, 32504
- Sacred Heart Hospital
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Pensacola, Florida, Forenede Stater, 32514
- Sacred Heart Medical Oncology Group - Davis Highway
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Georgia
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Atlanta, Georgia, Forenede Stater, 30309
- Piedmont Hospital
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Augusta, Georgia, Forenede Stater, 30901
- Augusta Oncology Associates PC-Saint Sebastian
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Columbus, Georgia, Forenede Stater, 31904
- John B Amos Cancer Center
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Decatur, Georgia, Forenede Stater, 30033
- Dekalb Medical Center
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Gainesville, Georgia, Forenede Stater, 30501
- Northeast Georgia Medical Center
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Savannah, Georgia, Forenede Stater, 31403
- Memorial Health University Medical Center
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Savannah, Georgia, Forenede Stater, 31405
- Saint Joseph's-Candler Health System
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Valdosta, Georgia, Forenede Stater, 31603
- South Georgia Medical Center
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Hawaii
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'Aiea, Hawaii, Forenede Stater, 96701
- Kapiolani Medical Center at Pali Momi
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'Aiea, Hawaii, Forenede Stater, 96701
- Oncare Hawaii Inc - Kapiolani Medical Center at Pali Momi
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Forenede Stater, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Forenede Stater, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Forenede Stater, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, Forenede Stater, 96819
- Kaiser Permanente Moanalua Medical Center
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Honolulu, Hawaii, Forenede Stater, 96813
- University of Hawaii
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Honolulu, Hawaii, Forenede Stater, 96813
- Oncare Hawaii Inc-POB II
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Honolulu, Hawaii, Forenede Stater, 96817-3169
- OnCare Hawaii-Liliha
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Honolulu, Hawaii, Forenede Stater, 96817
- Oncare Hawaii Inc-Kuakini
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Kailua, Hawaii, Forenede Stater, 96734
- Castle Medical Center
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Lihue, Hawaii, Forenede Stater, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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Idaho
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Boise, Idaho, Forenede Stater, 83712
- Saint Luke's Mountain States Tumor Institute
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Boise, Idaho, Forenede Stater, 83706
- Saint Alphonsus Regional Medical Center
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Fruitland, Idaho, Forenede Stater, 83619
- Saint Luke's Mountain States Tumor Institute - Fruitland
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Lewiston, Idaho, Forenede Stater, 83501
- Saint Joseph Regional Medical Center
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Meridian, Idaho, Forenede Stater, 83642
- Saint Luke's Mountain States Tumor Institute - Meridian
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Meridian, Idaho, Forenede Stater, 83642
- Idaho Urologic Institute PA
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Nampa, Idaho, Forenede Stater, 83686
- Saint Luke's Mountain States Tumor Institute - Nampa
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Post Falls, Idaho, Forenede Stater, 83854
- Kootenai Cancer Center
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Twin Falls, Idaho, Forenede Stater, 83301
- Saint Luke's Mountain States Tumor Institute-Twin Falls
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Illinois
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Aurora, Illinois, Forenede Stater, 60504
- Rush - Copley Medical Center
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Bloomington, Illinois, Forenede Stater, 61701
- Saint Joseph Medical Center
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Bloomington, Illinois, Forenede Stater, 61701
- Illinois CancerCare-Bloomington
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Canton, Illinois, Forenede Stater, 61520
- Illinois CancerCare-Canton
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Canton, Illinois, Forenede Stater, 61520
- Graham Hospital Association
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Carthage, Illinois, Forenede Stater, 62321
- Illinois CancerCare-Carthage
-
Carthage, Illinois, Forenede Stater, 62321
- Memorial Hospital
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Chicago, Illinois, Forenede Stater, 60611
- Northwestern University
-
Chicago, Illinois, Forenede Stater, 60612
- University of Illinois
-
Chicago, Illinois, Forenede Stater, 60608
- Mount Sinai Hospital Medical Center
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Chicago, Illinois, Forenede Stater, 60640
- Weiss Memorial Hospital
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Chicago, Illinois, Forenede Stater, 60612-3785
- John H Stroger Jr Hospital of Cook County
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Decatur, Illinois, Forenede Stater, 62526
- Decatur Memorial Hospital
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Eureka, Illinois, Forenede Stater, 61530
- Illinois CancerCare-Eureka
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Eureka, Illinois, Forenede Stater, 61530
- Eureka Hospital
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Evanston, Illinois, Forenede Stater, 60202
- Saint Francis Hospital
-
Evanston, Illinois, Forenede Stater, 60201
- Evanston CCOP-NorthShore University HealthSystem
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Freeport, Illinois, Forenede Stater, 61032
- FHN Leonard C. Ferguson Cancer Center
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Galesburg, Illinois, Forenede Stater, 61401
- Illinois CancerCare Galesburg
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Galesburg, Illinois, Forenede Stater, 61401
- Medical and Surgical Specialists
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Havana, Illinois, Forenede Stater, 62644
- Mason District Hospital
-
Havana, Illinois, Forenede Stater, 62644
- Illinois CancerCare-Havana
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Highland Park, Illinois, Forenede Stater, 60035
- Hematology Oncology Associates of Illinois-Highland Park
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Hinsdale, Illinois, Forenede Stater, 60521
- Hinsdale Hematology Oncology Associates Incorporated
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Joliet, Illinois, Forenede Stater, 60435
- Joliet Oncology-Hematology Associates Limited
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Kankakee, Illinois, Forenede Stater, 60901
- Presence Saint Mary's Hospital
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Kewanee, Illinois, Forenede Stater, 61443
- Illinois CancerCare-Kewanee Clinic
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La Grange, Illinois, Forenede Stater, 60525
- Adventist La Grange Memorial Hospital
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Libertyville, Illinois, Forenede Stater, 60048
- North Shore Hematology Oncology
-
Macomb, Illinois, Forenede Stater, 61455
- Illinois CancerCare-Macomb
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Macomb, Illinois, Forenede Stater, 61455
- Mcdonough District Hospital
-
Moline, Illinois, Forenede Stater, 61265
- Garneau, Stewart C MD (UIA Investigator)
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Moline, Illinois, Forenede Stater, 61265
- Porubcin, Michael MD (UIA Investigator)
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Moline, Illinois, Forenede Stater, 61265
- Spector, David MD (UIA Investigator)
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Moline, Illinois, Forenede Stater, 61265
- Trinity Medical Center
-
Monmouth, Illinois, Forenede Stater, 61462
- Illinois CancerCare-Monmouth
-
Monmouth, Illinois, Forenede Stater, 61462
- Holy Family Medical Center
-
Mount Vernon, Illinois, Forenede Stater, 62864
- Good Samaritan Regional Medical Center
-
Naperville, Illinois, Forenede Stater, 60540
- Hematology Oncology Consultants Limited
-
Naperville, Illinois, Forenede Stater, 60540
- Edward Hospital/Cancer Center
-
Niles, Illinois, Forenede Stater, 60714
- Illinois Cancer Specialists-Niles
-
Normal, Illinois, Forenede Stater, 61761
- Community Cancer Center Foundation
-
Normal, Illinois, Forenede Stater, 61761
- Bromenn Regional Medical Center
-
Normal, Illinois, Forenede Stater, 61761
- Illinois CancerCare-Community Cancer Center
-
Normal, Illinois, Forenede Stater, 61761
- Mid-Illinois Hematology Oncology Associates
-
Oak Lawn, Illinois, Forenede Stater, 60453-2699
- Advocate Christ Medical Center
-
Ottawa, Illinois, Forenede Stater, 61350
- Illinois CancerCare-Ottawa Clinic
-
Ottawa, Illinois, Forenede Stater, 61350
- Ottawa Regional Hospital and Healthcare Center
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Park Ridge, Illinois, Forenede Stater, 60068
- Advocate Lutheran General Hospital
-
Pekin, Illinois, Forenede Stater, 61554
- Pekin Cancer Treatment Center
-
Pekin, Illinois, Forenede Stater, 61603
- Illinois CancerCare-Pekin
-
Peoria, Illinois, Forenede Stater, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Forenede Stater, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, Forenede Stater, 61614
- Proctor Hospital
-
Peoria, Illinois, Forenede Stater, 61603
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Forenede Stater, 61615
- Illinois Oncology Research Association CCOP
-
Peru, Illinois, Forenede Stater, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Forenede Stater, 61354
- Illinois Valley Hospital
-
Princeton, Illinois, Forenede Stater, 61356
- Illinois CancerCare-Princeton
-
Princeton, Illinois, Forenede Stater, 61356
- Perry Memorial Hospital
-
River Forest, Illinois, Forenede Stater, 60305
- West Suburban Cancer Center
-
Rockford, Illinois, Forenede Stater, 61104
- Swedish American Hospital
-
Rockford, Illinois, Forenede Stater, 61107
- SwedishAmerican Regional Cancer Center/ACT
-
Skokie, Illinois, Forenede Stater, 60076
- Hematology Oncology Associates of Illinois - Skokie
-
Spring Valley, Illinois, Forenede Stater, 61362
- Illinois CancerCare-Spring Valley
-
Springfield, Illinois, Forenede Stater, 62781-0001
- Memorial Medical Center
-
Urbana, Illinois, Forenede Stater, 61801
- Carle Foundation - Carle Cancer Center
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Indiana
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Beech Grove, Indiana, Forenede Stater, 46107
- Saint Francis Hospital and Health Centers
-
Elkhart, Indiana, Forenede Stater, 46515
- Elkhart General Hospital
-
Elkhart, Indiana, Forenede Stater, 46514
- Michiana Hematology Oncology PC-Elkhart
-
Elkhart, Indiana, Forenede Stater, 46514-2098
- Elkhart Clinic
-
Fort Wayne, Indiana, Forenede Stater, 46845
- Fort Wayne Medical Oncology and Hematology Inc - State Boulevard
-
Indianapolis, Indiana, Forenede Stater, 46237
- Franciscan St. Francis Health
-
Indianapolis, Indiana, Forenede Stater, 46219
- Central Indiana Cancer Centers - Indianapolis
-
Kokomo, Indiana, Forenede Stater, 46904
- Community Howard Regional Health
-
La Porte, Indiana, Forenede Stater, 46350
- Indiana University Health La Porte Hospital
-
Lafayette, Indiana, Forenede Stater, 47904
- IU Health Arnett
-
Merrillville, Indiana, Forenede Stater, 46410
- Premier Oncology Hematology Associates
-
Michigan City, Indiana, Forenede Stater, 46360
- Saint Anthony Memorial Health Center
-
Mishawaka, Indiana, Forenede Stater, 46545-1470
- Saint Joseph Regional Medical Center-Mishawaka
-
Mishawaka, Indiana, Forenede Stater, 46545
- Cancer Care Partners LLC
-
Mishawaka, Indiana, Forenede Stater, 46545-1470
- Michiana Hematology Oncology PC-Mishawaka
-
Munster, Indiana, Forenede Stater, 46321
- The Community Hospital
-
Plymouth, Indiana, Forenede Stater, 46563
- Michiana Hematology Oncology PC-Plymouth
-
Richmond, Indiana, Forenede Stater, 47374
- Reid Hospital and Health Care Services
-
South Bend, Indiana, Forenede Stater, 46601
- Memorial Hospital of South Bend
-
South Bend, Indiana, Forenede Stater, 46601
- Michiana Hematology Oncology PC-South Bend
-
South Bend, Indiana, Forenede Stater, 46617
- South Bend Clinic
-
South Bend, Indiana, Forenede Stater, 46601
- Northern Indiana Cancer Research Consortium
-
Westville, Indiana, Forenede Stater, 46391
- Michiana Hematology Oncology-PC Westville
-
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Iowa
-
Ames, Iowa, Forenede Stater, 50010
- McFarland Clinic
-
Bettendorf, Iowa, Forenede Stater, 52722
- Constantinou, Costas L MD (UIA Investigator)
-
Bettendorf, Iowa, Forenede Stater, 52722
- Hematology Oncology Associates-Quad Cities
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Oncology Associates at Mercy Medical Center
-
Cedar Rapids, Iowa, Forenede Stater, 52402
- Saint Luke's Hospital
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Cedar Rapids Oncology Association
-
Cedar Rapids, Iowa, Forenede Stater, 52402
- Helen G Nassif Community Cancer Center
-
Clive, Iowa, Forenede Stater, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Forenede Stater, 50325
- Medical Oncology and Hematology Associates-West Des Moines
-
Davenport, Iowa, Forenede Stater, 52803
- Genesis Medical Center - East Campus
-
Des Moines, Iowa, Forenede Stater, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Forenede Stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forenede Stater, 50309
- Medical Oncology and Hematology Associates-Des Moines
-
Des Moines, Iowa, Forenede Stater, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Forenede Stater, 50309
- Iowa Oncology Research Association CCOP
-
Des Moines, Iowa, Forenede Stater, 50314
- Medical Oncology and Hematology Associates
-
Iowa City, Iowa, Forenede Stater, 52242
- University of Iowa Hospitals and Clinics
-
Mason City, Iowa, Forenede Stater, 50401
- Mercy Medical Center - North Iowa
-
Ottumwa, Iowa, Forenede Stater, 52501
- Ottumwa Regional Health Center
-
Sioux City, Iowa, Forenede Stater, 51104
- Saint Luke's Regional Medical Center
-
Sioux City, Iowa, Forenede Stater, 51101
- Siouxland Hematology Oncology Associates
-
Sioux City, Iowa, Forenede Stater, 51104
- Mercy Medical Center-Sioux City
-
Waterloo, Iowa, Forenede Stater, 50702
- Covenant Medical Center
-
West Des Moines, Iowa, Forenede Stater, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Forenede Stater, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, Forenede Stater, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, Forenede Stater, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Forenede Stater, 67042
- Cancer Center of Kansas - El Dorado
-
Emporia, Kansas, Forenede Stater, 66801
- Newman Regional Health
-
Fort Scott, Kansas, Forenede Stater, 66701
- Cancer Center of Kansas - Fort Scott
-
Great Bend, Kansas, Forenede Stater, 67530
- Saint Rose Ambulatory and Surgery Center
-
Hays, Kansas, Forenede Stater, 67601
- Hays Medical Center
-
Hutchinson, Kansas, Forenede Stater, 65702
- Promise Regional Medical Center-Hutchinson
-
Independence, Kansas, Forenede Stater, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, Forenede Stater, 66160
- University of Kansas Medical Center
-
Kansas City, Kansas, Forenede Stater, 66112
- Kansas City Cancer Center-West
-
Kingman, Kansas, Forenede Stater, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Forenede Stater, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, Forenede Stater, 67901
- Cancer Center of Kansas-Liberal
-
McPherson, Kansas, Forenede Stater, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, Forenede Stater, 67114
- Cancer Center of Kansas - Newton
-
Overland Park, Kansas, Forenede Stater, 66209
- Menorah Medical Center
-
Overland Park, Kansas, Forenede Stater, 66213
- Saint Luke's South Hospital
-
Overland Park, Kansas, Forenede Stater, 66210
- Kansas City Cancer Centers-Southwest
-
Parsons, Kansas, Forenede Stater, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, Forenede Stater, 66762
- Via Christi Hospital-Pittsburg
-
Prairie Village, Kansas, Forenede Stater, 66208
- Kansas City CCOP
-
Pratt, Kansas, Forenede Stater, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Forenede Stater, 67401
- Salina Regional Health Center
-
Salina, Kansas, Forenede Stater, 67401
- Cancer Center of Kansas - Salina
-
Shawnee Mission, Kansas, Forenede Stater, 66204
- Kansas City Cancer Center-Shawnee Mission
-
Topeka, Kansas, Forenede Stater, 66606
- Saint Francis Hospital and Medical Center - Topeka
-
Topeka, Kansas, Forenede Stater, 66604
- Stormont-Vail Regional Health Center
-
Wellington, Kansas, Forenede Stater, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, Forenede Stater, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Forenede Stater, 67208
- Associates In Womens Health
-
Wichita, Kansas, Forenede Stater, 67214
- Cancer Center of Kansas - Main Office
-
Wichita, Kansas, Forenede Stater, 67214
- Via Christi Regional Medical Center
-
Wichita, Kansas, Forenede Stater, 67214
- Wichita CCOP
-
Winfield, Kansas, Forenede Stater, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Corbin, Kentucky, Forenede Stater, 40701
- Baptist Regional Medical Center
-
Lexington, Kentucky, Forenede Stater, 40536
- University Of Kentucky
-
Lexington, Kentucky, Forenede Stater, 40503
- Baptist Health Lexington
-
Louisville, Kentucky, Forenede Stater, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Forenede Stater, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, Forenede Stater, 40202
- Norton Health Care Pavilion - Downtown
-
-
Louisiana
-
Alexandria, Louisiana, Forenede Stater, 71301
- Christus Saint Frances Cabrini Hospital
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Hematology/Oncology Clinic LLP
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Ochsner Clinic Foundation-Baton Rouge
-
Covington, Louisiana, Forenede Stater, 70433
- Ochsner North Shore Medical Center
-
New Orleans, Louisiana, Forenede Stater, 70112
- Tulane University Health Sciences Center
-
New Orleans, Louisiana, Forenede Stater, 70112
- Louisiana State University Health Science Center
-
New Orleans, Louisiana, Forenede Stater, 70112
- Interim LSU Public Hospital
-
New Orleans, Louisiana, Forenede Stater, 70115
- Ochsner Baptist Medical Center
-
New Orleans, Louisiana, Forenede Stater, 70121
- Ochsner Clinic CCOP
-
Shreveport, Louisiana, Forenede Stater, 71101
- Christus Schumpert Saint Mary's Place
-
-
Maine
-
Augusta, Maine, Forenede Stater, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, Forenede Stater, 04401
- Eastern Maine Medical Center
-
Portland, Maine, Forenede Stater, 04101
- Mercy Hospital
-
Rockport, Maine, Forenede Stater, 04856
- Penobscot Bay Medical Center
-
Scarborough, Maine, Forenede Stater, 04074
- Maine Center for Cancer Medicine and Blood Disorders-Scarborough
-
-
Maryland
-
Annapolis, Maryland, Forenede Stater, 21401
- Anne Arundel Medical Center
-
Baltimore, Maryland, Forenede Stater, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, Forenede Stater, 21229
- Saint Agnes Hospital
-
Baltimore, Maryland, Forenede Stater, 21287-8936
- Johns Hopkins University
-
Baltimore, Maryland, Forenede Stater, 21244
- Kaiser Permanente-Woodlawn Medical Center
-
Baltimore, Maryland, Forenede Stater, 21237
- Franklin Square Hospital Center
-
Baltimore, Maryland, Forenede Stater, 21218
- The Union Memorial Hospital
-
Columbia, Maryland, Forenede Stater, 21044
- Maryland Oncology Hematology PA-Columbia
-
Easton, Maryland, Forenede Stater, 21601
- The Memorial Hospital at Easton
-
Elkton, Maryland, Forenede Stater, 21921
- Union Hospital of Cecil County
-
Frederick, Maryland, Forenede Stater, 21701
- Frederick Memorial Hospital
-
Gaithersburg, Maryland, Forenede Stater, 20879
- Kaiser Permanente-Gaithersburg Medical Center
-
Largo, Maryland, Forenede Stater, 20774
- Kaiser Permanente - Largo Medical Center
-
Salisbury, Maryland, Forenede Stater, 21801
- Peninsula Regional Medical Center
-
Silver Spring, Maryland, Forenede Stater, 20910
- Holy Cross Hospital
-
-
Massachusetts
-
Beverly, Massachusetts, Forenede Stater, 01915
- Beverly Hospital
-
Boston, Massachusetts, Forenede Stater, 02111
- Tufts Medical Center
-
Boston, Massachusetts, Forenede Stater, 02118
- Boston Medical Center
-
Burlington, Massachusetts, Forenede Stater, 01805
- Lahey Hospital and Medical Center
-
Fall River, Massachusetts, Forenede Stater, 02721
- Saint Anne's Hospital
-
Gloucester, Massachusetts, Forenede Stater, 01930
- Addison Gilbert Hospital
-
Lowell, Massachusetts, Forenede Stater, 01854
- Lowell General Hospital
-
Methuen, Massachusetts, Forenede Stater, 01844
- Holy Family Hospital
-
Newton, Massachusetts, Forenede Stater, 02462
- Newton-Wellesley Hospital
-
Pittsfield, Massachusetts, Forenede Stater, 01201
- Berkshire Hematology Oncology PC
-
Plymouth, Massachusetts, Forenede Stater, 02360
- Jordan Hospital
-
Springfield, Massachusetts, Forenede Stater, 01199
- Baystate Medical Center
-
-
Michigan
-
Adrian, Michigan, Forenede Stater, 49221
- Bixby Medical Center
-
Adrian, Michigan, Forenede Stater, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, Forenede Stater, 48109
- University of Michigan
-
Ann Arbor, Michigan, Forenede Stater, 48106-0995
- Saint Joseph Mercy Hospital
-
Ann Arbor, Michigan, Forenede Stater, 48106
- Michigan Cancer Research Consortium Community Clinical Oncology Program
-
Battle Creek, Michigan, Forenede Stater, 49017
- Bronson Battle Creek
-
Bay City, Michigan, Forenede Stater, 48708
- Bay Regional Medical Center
-
Big Rapids, Michigan, Forenede Stater, 49307
- Mecosta County Medical Center
-
Clarkston, Michigan, Forenede Stater, 48346
- Great Lakes Cancer Institute
-
Dearborn, Michigan, Forenede Stater, 48124
- Oakwood Hospital
-
Detroit, Michigan, Forenede Stater, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Forenede Stater, 48236
- Saint John Hospital and Medical Center
-
Detroit, Michigan, Forenede Stater, 48202
- Wayne State University
-
Escanaba, Michigan, Forenede Stater, 49431
- Green Bay Oncology - Escanaba
-
Farmington Hills, Michigan, Forenede Stater, 48334
- Weisberg Cancer Treatment Center
-
Flint, Michigan, Forenede Stater, 48502
- Hurley Medical Center
-
Flint, Michigan, Forenede Stater, 48532
- Genesys Regional Medical Center-West Flint Campus
-
Flint, Michigan, Forenede Stater, 48532
- Singh and Arora Hematology Oncology PC
-
Flint, Michigan, Forenede Stater, 48503
- Genesys Hurley Cancer Institute
-
Flint, Michigan, Forenede Stater, 48532
- McLaren Regional Cancer Center
-
Grand Blanc, Michigan, Forenede Stater, 48439
- Genesys Regional Medical Center
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Spectrum Health at Butterworth Campus
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Grand Rapids Clinical Oncology Program
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Saint Mary's Health Care
-
Iron Mountain, Michigan, Forenede Stater, 49801
- Green Bay Oncology - Iron Mountain
-
Jackson, Michigan, Forenede Stater, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Forenede Stater, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Forenede Stater, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Forenede Stater, 49001
- Borgess Medical Center
-
Lansing, Michigan, Forenede Stater, 48912
- Sparrow Hospital
-
Lansing, Michigan, Forenede Stater, 48910
- Michigan State University - Breslin Cancer Center
-
Lapeer, Michigan, Forenede Stater, 48446
- Great Lakes Cancer Institute-Lapeer Campus
-
Livonia, Michigan, Forenede Stater, 48154
- Saint Mary Mercy Hospital
-
Marquette, Michigan, Forenede Stater, 49855
- Marquette General Hospital
-
Monroe, Michigan, Forenede Stater, 48162
- Mercy Memorial Hospital
-
Monroe, Michigan, Forenede Stater, 48162
- Community Cancer Center of Monroe
-
Mount Clemens, Michigan, Forenede Stater, 48043
- Mount Clemens Regional Medical Center
-
Muskegon, Michigan, Forenede Stater, 49444
- Mercy Health Partners-Mercy Campus
-
Owosso, Michigan, Forenede Stater, 48867
- Memorial Healthcare Center
-
Petoskey, Michigan, Forenede Stater, 49770
- Northern Michigan Regional Hospital
-
Pontiac, Michigan, Forenede Stater, 48341-2985
- Saint Joseph Mercy Oakland
-
Port Huron, Michigan, Forenede Stater, 48060
- Saint Joseph Mercy Port Huron
-
Reed City, Michigan, Forenede Stater, 49677
- Spectrum Health Reed City Hospital
-
Royal Oak, Michigan, Forenede Stater, 48073
- William Beaumont Hospital
-
Saginaw, Michigan, Forenede Stater, 48601
- Saint Mary's of Michigan
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Marie Yeager Cancer Center
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Lakeland Hospital
-
Southfield, Michigan, Forenede Stater, 48075
- Providence Hospital
-
Traverse City, Michigan, Forenede Stater, 49684
- Munson Medical Center
-
Troy, Michigan, Forenede Stater, 48098
- William Beaumont Hospital - Troy
-
Warren, Michigan, Forenede Stater, 48093
- Saint John Macomb-Oakland Hospital
-
-
Minnesota
-
Bemidji, Minnesota, Forenede Stater, 56601
- Sanford Clinic North-Bemidgi
-
Brainerd, Minnesota, Forenede Stater, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Forenede Stater, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Forenede Stater, 55433
- Mercy Hospital
-
Duluth, Minnesota, Forenede Stater, 55805
- Saint Luke's Hospital of Duluth
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Miller-Dwan Hospital
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Duluth Clinic CCOP
-
Edina, Minnesota, Forenede Stater, 55435
- Fairview-Southdale Hospital
-
Fergus Falls, Minnesota, Forenede Stater, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, Forenede Stater, 55432
- Unity Hospital
-
Hutchinson, Minnesota, Forenede Stater, 55350
- Hutchinson Area Health Care
-
Mankato, Minnesota, Forenede Stater, 56002
- Mayo Clinic Health System in Mankato
-
Maplewood, Minnesota, Forenede Stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forenede Stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forenede Stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Abbott-Northwestern Hospital
-
New Ulm, Minnesota, Forenede Stater, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, Forenede Stater, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Forenede Stater, 55905
- Mayo Clinic
-
Saint Cloud, Minnesota, Forenede Stater, 56303
- Saint Cloud Hospital
-
Saint Cloud, Minnesota, Forenede Stater, 56303
- CentraCare Clinic
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Metro-Minnesota CCOP
-
Saint Paul, Minnesota, Forenede Stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forenede Stater, 55102
- United Hospital
-
Shakopee, Minnesota, Forenede Stater, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Forenede Stater, 55082
- Lakeview Hospital
-
Waconia, Minnesota, Forenede Stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forenede Stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forenede Stater, 55125
- Minnesota Oncology and Hematology PA-Woodbury
-
-
Mississippi
-
Gulfport, Mississippi, Forenede Stater, 39502
- Gulfport Memorial Hospital
-
Hattiesburg, Mississippi, Forenede Stater, 39404
- Forest General Hospital
-
Jackson, Mississippi, Forenede Stater, 39216
- University of Mississippi Medical Center
-
Pascagoula, Mississippi, Forenede Stater, 39581
- Singing River Hospital
-
-
Missouri
-
Bolivar, Missouri, Forenede Stater, 65613
- Central Care Cancer Center-Carrie J Babb Cancer Center
-
Branson, Missouri, Forenede Stater, 65616
- CoxHealth Cancer Center
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Southeast Cancer Center
-
Chesterfield, Missouri, Forenede Stater, 63017
- Saint Luke's Hospital
-
Columbia, Missouri, Forenede Stater, 65203
- University of Missouri - Ellis Fischel
-
Jefferson City, Missouri, Forenede Stater, 65109
- Capital Region Medical Center-Goldschmidt Cancer Center
-
Joplin, Missouri, Forenede Stater, 64804
- Freeman Health System
-
Joplin, Missouri, Forenede Stater, 64804
- Saint John's Regional Medical Center
-
Kansas City, Missouri, Forenede Stater, 64116
- North Kansas City Hospital
-
Kansas City, Missouri, Forenede Stater, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, Forenede Stater, 64132
- Research Medical Center
-
Kansas City, Missouri, Forenede Stater, 64108
- Truman Medical Center
-
Kansas City, Missouri, Forenede Stater, 64118
- Heartland Hematology and Oncology Associates Incorporated
-
Kansas City, Missouri, Forenede Stater, 64111
- Saint Luke's Cancer Institute
-
Kansas City, Missouri, Forenede Stater, 64131
- Kansas City Cancer Center - South
-
Kansas City, Missouri, Forenede Stater, 64154
- Kansas City Cancer Centers - North
-
Lee's Summit, Missouri, Forenede Stater, 64086
- Saint Luke's East - Lee's Summit
-
Lee's Summit, Missouri, Forenede Stater, 64064
- Kansas City Cancer Center-Lee's Summit
-
Liberty, Missouri, Forenede Stater, 64068
- Liberty Radiation Oncology Clinic
-
Rolla, Missouri, Forenede Stater, 65401
- Phelps County Regional Medical Center
-
Rolla, Missouri, Forenede Stater, 65401
- Saint John's Clinic-Rolla-Cancer and Hematology
-
Saint Joseph, Missouri, Forenede Stater, 64506
- Heartland Regional Medical Center
-
Saint Joseph, Missouri, Forenede Stater, 64507
- Saint Joseph Oncology Inc
-
Saint Louis, Missouri, Forenede Stater, 63110
- Washington University School of Medicine
-
Saint Louis, Missouri, Forenede Stater, 63110
- Saint Louis University Hospital
-
Saint Louis, Missouri, Forenede Stater, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Saint Louis, Missouri, Forenede Stater, 63141
- Saint John's Mercy Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63141
- Saint Louis-Cape Girardeau CCOP
-
Saint Louis, Missouri, Forenede Stater, 63141
- Comprehensive Cancer Care PC
-
Springfield, Missouri, Forenede Stater, 65802
- Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield
-
Springfield, Missouri, Forenede Stater, 65807
- Cox Medical Center
-
Springfield, Missouri, Forenede Stater, 65804
- Saint John's Hospital
-
-
Montana
-
Billings, Montana, Forenede Stater, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Forenede Stater, 59101
- Montana Cancer Consortium CCOP
-
Billings, Montana, Forenede Stater, 59102
- Hematology-Oncology Centers of the Northern Rockies PC
-
Billings, Montana, Forenede Stater, 59107-7000
- Billings Clinic
-
Bozeman, Montana, Forenede Stater, 59715
- Bozeman Deaconess Hospital
-
Bozeman, Montana, Forenede Stater, 59715
- Bozeman Deaconess Cancer Center
-
Butte, Montana, Forenede Stater, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Forenede Stater, 59405
- Great Falls Clinic
-
Great Falls, Montana, Forenede Stater, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Great Falls, Montana, Forenede Stater, 59405
- Big Sky Oncology
-
Havre, Montana, Forenede Stater, 59501
- Northern Montana Hospital
-
Helena, Montana, Forenede Stater, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Forenede Stater, 59901
- Kalispell Regional Medical Center
-
Kalispell, Montana, Forenede Stater, 59901
- Glacier Oncology PLLC
-
Kalispell, Montana, Forenede Stater, 59901
- Kalispell Medical Oncology
-
Missoula, Montana, Forenede Stater, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Forenede Stater, 59802
- Montana Cancer Specialists
-
-
Nebraska
-
Kearney, Nebraska, Forenede Stater, 68847
- Good Samaritan Hospital
-
Lincoln, Nebraska, Forenede Stater, 68510
- Lincoln Medical Education Foundation Cancer Resource Center
-
Omaha, Nebraska, Forenede Stater, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, Forenede Stater, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Forenede Stater, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Forenede Stater, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Forenede Stater, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, Forenede Stater, 68106
- Missouri Valley Cancer Consortium CCOP
-
-
Nevada
-
Las Vegas, Nevada, Forenede Stater, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Forenede Stater, 89106
- Nevada Cancer Research Foundation CCOP
-
-
New Hampshire
-
Concord, New Hampshire, Forenede Stater, 03301
- New Hampshire Oncology-Hematology PA
-
Hooksett, New Hampshire, Forenede Stater, 03106
- New Hampshire Oncology Hematology Associates
-
Laconia, New Hampshire, Forenede Stater, 03246
- LRGHealthcare-Lakes Region General Hospital
-
Nashua, New Hampshire, Forenede Stater, 03060
- Saint Joseph Hospital
-
Portsmouth, New Hampshire, Forenede Stater, 03802
- Portsmouth Regional Hospital
-
-
New Jersey
-
Camden, New Jersey, Forenede Stater, 08103
- Cooper Hospital University Medical Center
-
Englewood, New Jersey, Forenede Stater, 07631
- Englewood Hospital and Medical Center
-
Flemington, New Jersey, Forenede Stater, 08822
- Hunterdon Medical Center
-
Hamilton, New Jersey, Forenede Stater, 08690
- Cancer Institute of New Jersey at Hamilton
-
Neptune, New Jersey, Forenede Stater, 07753
- Jersey Shore Medical Center
-
New Brunswick, New Jersey, Forenede Stater, 08903
- Cancer Institute of New Jersey
-
Newark, New Jersey, Forenede Stater, 07112
- Newark Beth Israel Medical Center
-
Pennington, New Jersey, Forenede Stater, 08534
- Capital Health Medical Center-Hopewell
-
Ridgewood, New Jersey, Forenede Stater, 07450
- Valley Hospital
-
Somerville, New Jersey, Forenede Stater, 08876
- Somerset Medical Center
-
Sparta, New Jersey, Forenede Stater, 07871
- Sparta Cancer Treatment Center
-
Toms River, New Jersey, Forenede Stater, 08755
- Community Medical Center
-
Vineland, New Jersey, Forenede Stater, 08360
- South Jersey Healthcare
-
-
New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87106
- University of New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87109
- New Mexico Oncology Hematology Consultants
-
Albuquerque, New Mexico, Forenede Stater, 87106
- Hematology Oncology Associates
-
Albuquerque, New Mexico, Forenede Stater, 87110
- Presbyterian Kaseman Hospital
-
Las Cruces, New Mexico, Forenede Stater, 88011
- Memorial Medical Center - Las Cruces
-
Santa Fe, New Mexico, Forenede Stater, 87505
- New Mexico Cancer Care Associates
-
-
New York
-
Albany, New York, Forenede Stater, 12208
- New York Oncology Hematology PC -Albany Medical Center
-
Albany, New York, Forenede Stater, 12206
- New York Oncology Hematology PC - Albany
-
Amsterdam, New York, Forenede Stater, 12010
- New York Oncology Hematology PC - Amsterdam
-
Bronx, New York, Forenede Stater, 10461
- Albert Einstein College of Medicine
-
Bronx, New York, Forenede Stater, 10467-2490
- Montefiore Medical Center
-
Brooklyn, New York, Forenede Stater, 11219
- Maimonides Medical Center
-
Brooklyn, New York, Forenede Stater, 11203
- Kings County Hospital
-
Brooklyn, New York, Forenede Stater, 11203
- State University of New York Downstate Medical Center
-
Buffalo, New York, Forenede Stater, 14263
- Roswell Park Cancer Institute
-
Cooperstown, New York, Forenede Stater, 13326
- Mary Imogene Bassett Hospital
-
East Syracuse, New York, Forenede Stater, 13057
- Hematology Oncology Associates of Central New York PC
-
Hudson, New York, Forenede Stater, 12534
- New York Oncology Hematology PC-Hudson
-
Johnson City, New York, Forenede Stater, 13790
- Broome Oncology LLC
-
Lake Success, New York, Forenede Stater, 11042
- Monter Cancer Center
-
Latham, New York, Forenede Stater, 12110
- New York Oncology Hematology PC - Latham
-
Manhasset, New York, Forenede Stater, 11030
- North Shore University Hospital
-
Manhasset, New York, Forenede Stater, 11030
- North Shore-LIJ Health System CCOP
-
Mineola, New York, Forenede Stater, 11501
- Winthrop University Hospital
-
New Hyde Park, New York, Forenede Stater, 11040
- Long Island Jewish Medical Center
-
New York, New York, Forenede Stater, 10032
- Columbia University Medical Center
-
New York, New York, Forenede Stater, 10029
- Mount Sinai Medical Center
-
Poughkeepsie, New York, Forenede Stater, 12601
- Vassar Brothers Medical Center
-
Poughkeepsie, New York, Forenede Stater, 12601
- Saint Francis
-
Rochester, New York, Forenede Stater, 14642
- University of Rochester
-
Staten Island, New York, Forenede Stater, 10305
- Staten Island University Hospital
-
Stony Brook, New York, Forenede Stater, 11794
- Stony Brook University Medical Center
-
-
North Carolina
-
Asheboro, North Carolina, Forenede Stater, 27203
- Randolph Hospital
-
Asheville, North Carolina, Forenede Stater, 28801
- Mission Hospitals
-
Asheville, North Carolina, Forenede Stater, 28816
- Hope Women's Cancer Centers-Asheville
-
Burlington, North Carolina, Forenede Stater, 27216
- Alamance Regional Medical Center
-
Cary, North Carolina, Forenede Stater, 27518
- Waverly Hematology Oncology
-
Charlotte, North Carolina, Forenede Stater, 28203
- Carolinas Medical Center
-
Charlotte, North Carolina, Forenede Stater, 28204
- Presbyterian Hospital
-
Concord, North Carolina, Forenede Stater, 28025
- Carolinas Medical Center - Northeast
-
Gastonia, North Carolina, Forenede Stater, 28054
- Gaston Memorial Hospital
-
Goldsboro, North Carolina, Forenede Stater, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, Forenede Stater, 27403
- Cone Health Cancer Center
-
Hendersonville, North Carolina, Forenede Stater, 28791
- Margaret R Pardee Memorial Hospital
-
Hendersonville, North Carolina, Forenede Stater, 28792
- Park Ridge Hospital Breast Health Center
-
Kinston, North Carolina, Forenede Stater, 28501
- Kinston Medical Specialists PA
-
Monroe, North Carolina, Forenede Stater, 28112
- Carolinas Medical Center-Union
-
Pinehurst, North Carolina, Forenede Stater, 28374
- FirstHealth of the Carolinas-Moore Regional Hosiptal
-
Raleigh, North Carolina, Forenede Stater, 27607
- Rex Cancer Center
-
Raleigh, North Carolina, Forenede Stater, 27614
- Rex Cancer Center of Wakefield
-
Reidsville, North Carolina, Forenede Stater, 27320
- Annie Penn Memorial Hospital
-
Rutherfordton, North Carolina, Forenede Stater, 28139
- Rutherford Hospital
-
Shelby, North Carolina, Forenede Stater, 28150
- Cleveland Regional Medical Center
-
Statesville, North Carolina, Forenede Stater, 28677
- Iredell Memorial Hospital
-
Washington, North Carolina, Forenede Stater, 27889
- Marion L Shepard Cancer Center
-
Wilmington, North Carolina, Forenede Stater, 28401
- New Hanover Regional Medical Center
-
Winston-Salem, North Carolina, Forenede Stater, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, Forenede Stater, 27103
- Forsyth Memorial Hospital
-
-
North Dakota
-
Bismarck, North Dakota, Forenede Stater, 58501
- Sanford Bismarck Medical Center
-
Bismarck, North Dakota, Forenede Stater, 58501
- Bismarck Cancer Center
-
Bismarck, North Dakota, Forenede Stater, 58501
- Mid Dakota Clinic
-
Bismarck, North Dakota, Forenede Stater, 58501
- Saint Alexius Medical Center
-
Fargo, North Dakota, Forenede Stater, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Clinic North-Fargo
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Medical Center-Fargo
-
Fargo, North Dakota, Forenede Stater, 58122
- Roger Maris Cancer Center
-
Grand Forks, North Dakota, Forenede Stater, 58201
- Altru Cancer Center
-
-
Ohio
-
Akron, Ohio, Forenede Stater, 44307
- Akron General Medical Center
-
Akron, Ohio, Forenede Stater, 44304
- Summa Akron City Hospital
-
Barberton, Ohio, Forenede Stater, 44203
- Summa Barberton Hospital
-
Beachwood, Ohio, Forenede Stater, 44122
- Cleveland Clinic Cancer Center Beachwood
-
Belpre, Ohio, Forenede Stater, 45714
- Strecker Cancer Center-Belpre
-
Bowling Green, Ohio, Forenede Stater, 43402
- Toledo Clinic Cancer Centers-Bowling Green
-
Canton, Ohio, Forenede Stater, 44710
- Aultman Health Foundation
-
Canton, Ohio, Forenede Stater, 44708
- Mercy Medical Center
-
Chillicothe, Ohio, Forenede Stater, 45601
- Adena Regional Medical Center
-
Cleveland, Ohio, Forenede Stater, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Forenede Stater, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, Forenede Stater, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Columbus, Ohio, Forenede Stater, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Forenede Stater, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Forenede Stater, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Forenede Stater, 43228
- Doctors Hospital
-
Columbus, Ohio, Forenede Stater, 43215
- Grant Medical Center
-
Columbus, Ohio, Forenede Stater, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, Forenede Stater, 43215
- Columbus CCOP
-
Dayton, Ohio, Forenede Stater, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Forenede Stater, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Forenede Stater, 45415
- Samaritan North Health Center
-
Dayton, Ohio, Forenede Stater, 45405
- Grandview Hospital
-
Dayton, Ohio, Forenede Stater, 45420
- Dayton CCOP
-
Delaware, Ohio, Forenede Stater, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Forenede Stater, 43015
- Grady Memorial Hospital
-
Elyria, Ohio, Forenede Stater, 44035
- Hematology Oncology Center Incorporated
-
Elyria, Ohio, Forenede Stater, 44035
- Community Health Partners Regional Medical Center
-
Findlay, Ohio, Forenede Stater, 45840
- Blanchard Valley Hospital
-
Franklin, Ohio, Forenede Stater, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Greenville, Ohio, Forenede Stater, 45331
- Wayne Hospital
-
Independence, Ohio, Forenede Stater, 44131
- Cleveland Clinic Cancer Center Independence
-
Kettering, Ohio, Forenede Stater, 45429
- Kettering Medical Center
-
Lancaster, Ohio, Forenede Stater, 43130
- Fairfield Medical Center
-
Lima, Ohio, Forenede Stater, 45801
- Saint Rita's Medical Center
-
Lima, Ohio, Forenede Stater, 45804
- Lima Memorial Hospital
-
Mansfield, Ohio, Forenede Stater, 44903
- Mansfield General Hospital-MedCentral Health System
-
Marietta, Ohio, Forenede Stater, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, Forenede Stater, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Maumee, Ohio, Forenede Stater, 43537-1839
- Toledo Clinic Cancer Centers-Maumee
-
Mayfield Heights, Ohio, Forenede Stater, 44124
- Hillcrest Hospital Cancer Center
-
Mount Vernon, Ohio, Forenede Stater, 43050
- Knox Community Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Licking Memorial Hospital
-
Oregon, Ohio, Forenede Stater, 43616
- Saint Charles Hospital
-
Oregon, Ohio, Forenede Stater, 43616
- Toledo Clinic Cancer Centers-Oregon
-
Parma, Ohio, Forenede Stater, 44129
- Parma Community General Hospital
-
Portsmouth, Ohio, Forenede Stater, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, Forenede Stater, 44870
- North Coast Cancer Care
-
Springfield, Ohio, Forenede Stater, 45505
- Springfield Regional Medical Center
-
Steubenville, Ohio, Forenede Stater, 43952
- Trinity's Tony Teramana Cancer Center
-
Strongsville, Ohio, Forenede Stater, 44136
- Cleveland Clinic Cancer Center-Strongsville
-
Sylvania, Ohio, Forenede Stater, 43560
- Flower Hospital
-
Tiffin, Ohio, Forenede Stater, 44883
- Mercy Hospital of Tiffin
-
Toledo, Ohio, Forenede Stater, 43608
- Saint Vincent Mercy Medical Center
-
Toledo, Ohio, Forenede Stater, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Forenede Stater, 43614
- University of Toledo
-
Toledo, Ohio, Forenede Stater, 43617
- Toledo Community Hospital Oncology Program CCOP
-
Toledo, Ohio, Forenede Stater, 43606
- The Toledo Hospital/Toledo Children's Hospital
-
Toledo, Ohio, Forenede Stater, 43623
- Mercy Cancer Center at Saint Anne Mercy Hospital
-
Troy, Ohio, Forenede Stater, 45373
- Upper Valley Medical Center
-
Wauseon, Ohio, Forenede Stater, 43567
- Fulton County Health Center
-
Westerville, Ohio, Forenede Stater, 43081
- Saint Ann's Hospital
-
Wooster, Ohio, Forenede Stater, 44691
- Cleveland Clinic Wooster Specialty Center
-
Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433-5529
- Wright-Patterson Medical Center
-
Xenia, Ohio, Forenede Stater, 45385
- Greene Memorial Hospital
-
Zanesville, Ohio, Forenede Stater, 43701
- Genesis HealthCare System
-
-
Oklahoma
-
Lawton, Oklahoma, Forenede Stater, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Norman, Oklahoma, Forenede Stater, 73071
- Cancer Care Associates-Norman
-
Oklahoma City, Oklahoma, Forenede Stater, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Forenede Stater, 73120
- Cancer Care Associates-Mercy
-
Tulsa, Oklahoma, Forenede Stater, 74136
- Natalie W Bryant Cancer Center
-
-
Oregon
-
Clackamas, Oregon, Forenede Stater, 97015
- Clackamas Radiation Oncology Center
-
Grants Pass, Oregon, Forenede Stater, 97527
- Three Rivers Community Hospital
-
Gresham, Oregon, Forenede Stater, 97030
- Legacy Mount Hood Medical Center
-
Medford, Oregon, Forenede Stater, 97504
- Asante Health System
-
Medford, Oregon, Forenede Stater, 97504
- Providence Medford Medical Center
-
Medford, Oregon, Forenede Stater, 97504
- Rogue Valley Medical Center
-
Milwaukie, Oregon, Forenede Stater, 97222
- Providence Milwaukie Hospital
-
Newberg, Oregon, Forenede Stater, 97132
- Providence Newberg Medical Center
-
Oregon City, Oregon, Forenede Stater, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, Forenede Stater, 97210
- Legacy Good Samaritan Hospital and Medical Center
-
Portland, Oregon, Forenede Stater, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Forenede Stater, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Forenede Stater, 97227
- Kaiser Permanente
-
Portland, Oregon, Forenede Stater, 97225
- Columbia River Oncology Program
-
The Dalles, Oregon, Forenede Stater, 97058
- Mid-Columbia Medical Center
-
Tualatin, Oregon, Forenede Stater, 97062
- Legacy Meridian Park Hospital
-
-
Pennsylvania
-
Abington, Pennsylvania, Forenede Stater, 19001
- Abington Memorial Hospital
-
Allentown, Pennsylvania, Forenede Stater, 18105
- Lehigh Valley Hospital
-
Bethlehem, Pennsylvania, Forenede Stater, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bryn Mawr, Pennsylvania, Forenede Stater, 19010
- Bryn Mawr Hospital
-
Danville, Pennsylvania, Forenede Stater, 17822-2001
- Geisinger Medical Center
-
Doylestown, Pennsylvania, Forenede Stater, 18901
- Doylestown Hospital
-
Ephrata, Pennsylvania, Forenede Stater, 17522
- Ephrata Cancer Center
-
Erie, Pennsylvania, Forenede Stater, 16505
- The Regional Cancer Center
-
Gettysburg, Pennsylvania, Forenede Stater, 17325
- Adams Cancer Center
-
Hanover, Pennsylvania, Forenede Stater, 17331
- Cherry Tree Cancer Center
-
Harrisburg, Pennsylvania, Forenede Stater, 17110
- PinnacleHealth Fox Chase Regional Cancer Center at Polyclinic Hospital
-
Hazleton, Pennsylvania, Forenede Stater, 18201
- Geisinger Medical Center-Cancer Center Hazelton
-
Hershey, Pennsylvania, Forenede Stater, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Kingston, Pennsylvania, Forenede Stater, 18704
- Medical Oncology Associates
-
Kittanning, Pennsylvania, Forenede Stater, 16201
- Armstrong Center for Medicine and Health
-
Media, Pennsylvania, Forenede Stater, 19063
- Riddle Hospital
-
Monroeville, Pennsylvania, Forenede Stater, 15146
- Forbes Regional Hospital
-
Natrona Heights, Pennsylvania, Forenede Stater, 15065
- Alle-Kiski Medical Center
-
Paoli, Pennsylvania, Forenede Stater, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19107
- Pennsylvania Hospital
-
Phoenixville, Pennsylvania, Forenede Stater, 19460
- Phoenixville Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15232
- University of Pittsburgh
-
Pittsburgh, Pennsylvania, Forenede Stater, 15212
- Allegheny Cancer Center at Allegheny General Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15224-1791
- Western Pennsylvania Hospital
-
Pottstown, Pennsylvania, Forenede Stater, 19464
- Pottstown Memorial Medical Center
-
Reading, Pennsylvania, Forenede Stater, 19605
- Saint Joseph Medical Center
-
Sayre, Pennsylvania, Forenede Stater, 18840
- Guthrie Clinic-Robert Packer Hospital
-
Scranton, Pennsylvania, Forenede Stater, 18510
- Scranton Hematology Oncology
-
Scranton, Pennsylvania, Forenede Stater, 18501
- Mercy Hospital
-
Scranton, Pennsylvania, Forenede Stater, 18508
- Hematology and Oncology Associates of North East Pennsylvania
-
Sellersville, Pennsylvania, Forenede Stater, 18960
- Grand View Hospital
-
State College, Pennsylvania, Forenede Stater, 16801
- Geisinger Medical Group
-
Upland, Pennsylvania, Forenede Stater, 19013
- Associates In Hematology Oncology PC-Upland
-
West Chester, Pennsylvania, Forenede Stater, 19380
- Chester County Hospital
-
West Reading, Pennsylvania, Forenede Stater, 19612
- Reading Hospital and Medical Center
-
Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
- Geisinger Wyoming Valley
-
Williamsport, Pennsylvania, Forenede Stater, 17701
- Susquehanna Cancer Center
-
Wynnewood, Pennsylvania, Forenede Stater, 19096
- Lankenau Hospital
-
Wynnewood, Pennsylvania, Forenede Stater, 19096
- Mainline Health CCOP
-
York, Pennsylvania, Forenede Stater, 17405
- York Hospital
-
-
Rhode Island
-
Providence, Rhode Island, Forenede Stater, 02903
- Rhode Island Hospital
-
Providence, Rhode Island, Forenede Stater, 02905
- Women and Infants Hospital
-
Providence, Rhode Island, Forenede Stater, 02906
- Miriam Hospital
-
Warwick, Rhode Island, Forenede Stater, 02886
- Kent County Hospital
-
-
South Carolina
-
Anderson, South Carolina, Forenede Stater, 29621
- AnMed Health Cancer Center
-
Anderson, South Carolina, Forenede Stater, 29621
- AnMed Health Hospital
-
Beaufort, South Carolina, Forenede Stater, 29902
- Beaufort Memorial Hospital
-
Charleston, South Carolina, Forenede Stater, 29425
- Medical University of South Carolina
-
Charleston, South Carolina, Forenede Stater, 29401
- Roper Hospital
-
Florence, South Carolina, Forenede Stater, 29506
- McLeod Regional Medical Center
-
Greenville, South Carolina, Forenede Stater, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, Forenede Stater, 29605
- Greenville Memorial Hospital
-
Greenville, South Carolina, Forenede Stater, 29605
- Cancer Centers of the Carolinas - Grove Commons
-
Greenville, South Carolina, Forenede Stater, 29605
- Cancer Centers of the Carolinas - Faris
-
Greenville, South Carolina, Forenede Stater, 29615
- Greenville CCOP
-
Greenwood, South Carolina, Forenede Stater, 29646
- Self Regional Healthcare
-
Greer, South Carolina, Forenede Stater, 29651
- Gibbs Cancer Center-Pelham
-
Greer, South Carolina, Forenede Stater, 29650
- Cancer Centers of the Carolinas-Greer Medical Oncology
-
Seneca, South Carolina, Forenede Stater, 29672
- Cancer Centers of the Carolinas - Seneca
-
Spartanburg, South Carolina, Forenede Stater, 29303
- Spartanburg Regional Medical Center
-
Spartanburg, South Carolina, Forenede Stater, 29303
- Upstate Carolina CCOP
-
Spartanburg, South Carolina, Forenede Stater, 29307
- Cancer Centers of the Carolinas - Spartanburg
-
-
South Dakota
-
Aberdeen, South Dakota, Forenede Stater, 57401
- Conklin Regional Cancer Center
-
Rapid City, South Dakota, Forenede Stater, 57701
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, Forenede Stater, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Forenede Stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forenede Stater, 57104
- Sanford Cancer Center-Oncology Clinic
-
-
Tennessee
-
Bristol, Tennessee, Forenede Stater, 37620
- Wellmont Bristol Regional Medical Center
-
Bristol, Tennessee, Forenede Stater, 37620
- Blue Ridge Medical Specialists PC
-
Chattanooga, Tennessee, Forenede Stater, 37403
- Erlanger Medical Center
-
Kingsport, Tennessee, Forenede Stater, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Knoxville, Tennessee, Forenede Stater, 37916
- Thompson Cancer Survival Center
-
Knoxville, Tennessee, Forenede Stater, 37920
- University of Tennessee - Knoxville
-
-
Texas
-
Abilene, Texas, Forenede Stater, 79606
- Texas Cancer Center
-
Amarillo, Texas, Forenede Stater, 79106
- Texas Oncology PA - Amarillo
-
Arlington, Texas, Forenede Stater, 76014
- Texas Oncology-Arlington South
-
Beaumont, Texas, Forenede Stater, 77702
- Texas Oncology PA Beaumont
-
Bedford, Texas, Forenede Stater, 76022
- Texas Oncology PA - Bedford
-
Bryan, Texas, Forenede Stater, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, Forenede Stater, 75230
- Texas Cancer Center - Medical City Dallas
-
Dallas, Texas, Forenede Stater, 75237
- Texas Oncology Methodist Charlton Cancer Center
-
Dallas, Texas, Forenede Stater, 75231
- Texas Health Presbyterian Hospital Dallas
-
Dallas, Texas, Forenede Stater, 75246
- Texas Oncology Pa
-
Denton, Texas, Forenede Stater, 76210
- Texas Oncology-Denton South
-
El Paso, Texas, Forenede Stater, 79915
- Texas Oncology-El Paso
-
Flower Mound, Texas, Forenede Stater, 75028
- Texas Oncology-Flower Mound
-
Fort Worth, Texas, Forenede Stater, 76104
- Texas Oncology Fort Worth at 12th Avenue
-
Garland, Texas, Forenede Stater, 75042
- Texas Oncology - Garland
-
Houston, Texas, Forenede Stater, 77030
- Baylor College of Medicine
-
Houston, Texas, Forenede Stater, 77030
- Methodist Hospital
-
Houston, Texas, Forenede Stater, 77024
- Memorial Hermann Memorial City Medical Center
-
Lewisville, Texas, Forenede Stater, 75067
- Texas Oncology - Lewisville
-
Lubbock, Texas, Forenede Stater, 79410
- Covenant Medical Center-Lakeside
-
Lubbock, Texas, Forenede Stater, 79430
- Texas Tech University Health Sciences Center
-
McAllen, Texas, Forenede Stater, 78503
- Texas Oncology-McAllen
-
Mesquite, Texas, Forenede Stater, 75150
- Texas Cancer Center - Mesquite
-
Midland, Texas, Forenede Stater, 79701
- Texas Oncology-Midland Allison Cancer Center
-
Paris, Texas, Forenede Stater, 75460
- Texas Oncology-Paris
-
Plano, Texas, Forenede Stater, 75075
- North Texas Regional Cancer Center
-
Round Rock, Texas, Forenede Stater, 78681
- Texas Oncology - Round Rock Cancer Center
-
Round Rock, Texas, Forenede Stater, 78665
- Scott and White Healthcare Round Rock
-
San Antonio, Texas, Forenede Stater, 78229-3900
- University of Texas Health Science Center at San Antonio
-
San Antonio, Texas, Forenede Stater, 78217
- Cancer Care Centers of South Texas- Northeast
-
Sherman, Texas, Forenede Stater, 75090
- Texas Cancer Center-Sherman
-
Temple, Texas, Forenede Stater, 76508
- Scott and White Memorial Hospital
-
The Woodlands, Texas, Forenede Stater, 77380
- US Oncology Research LLC-The Woodlands
-
Tyler, Texas, Forenede Stater, 75702
- Tyler Cancer Center
-
Waco, Texas, Forenede Stater, 76712
- Texas Oncology Pa
-
-
Utah
-
American Fork, Utah, Forenede Stater, 84003
- American Fork Hospital
-
Cedar City, Utah, Forenede Stater, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, Forenede Stater, 84321
- Logan Regional Hospital
-
Murray, Utah, Forenede Stater, 84157
- Intermountain Medical Center
-
Ogden, Utah, Forenede Stater, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Forenede Stater, 84604-3337
- Utah Valley Regional Medical Center
-
Saint George, Utah, Forenede Stater, 84770
- Dixie Medical Center Regional Cancer Center
-
Salt Lake City, Utah, Forenede Stater, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, Forenede Stater, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Forenede Stater, 84143
- LDS Hospital
-
-
Vermont
-
Berlin, Vermont, Forenede Stater, 05602
- Mountainview Medical
-
Burlington, Vermont, Forenede Stater, 05401
- University of Vermont
-
Rutland, Vermont, Forenede Stater, 05701
- Rutland Regional Medical Center
-
-
Virginia
-
Burke, Virginia, Forenede Stater, 22015
- Kaiser Permanente-Burke Medical Center
-
Charlottesville, Virginia, Forenede Stater, 22908
- University of Virginia
-
Fairfax, Virginia, Forenede Stater, 22033
- Kaiser Permanente - Fair Oaks Medical Center
-
Fairfax, Virginia, Forenede Stater, 22031
- Virginia Cancer Specialists-Fairfax
-
Fredericksburg, Virginia, Forenede Stater, 22401
- Fredericksburg Oncology Inc
-
Fredericksburg, Virginia, Forenede Stater, 22408
- Hematology Oncology Associates of Fredericksburg Inc
-
Gloucester, Virginia, Forenede Stater, 23061
- Peninsula Cancer Institute-Gloucester
-
Hampton, Virginia, Forenede Stater, 23666
- Virginia Oncology Associates-Hampton
-
McLean, Virginia, Forenede Stater, 22102
- Kaiser Permanente Tysons Corner Medical Center
-
Newport News, Virginia, Forenede Stater, 23601
- Peninsula Cancer Institute-Newport News
-
Norton, Virginia, Forenede Stater, 24273
- Southwest VA Regional Cancer Center
-
Richmond, Virginia, Forenede Stater, 23298
- Virginia Commonwealth University
-
Roanoke, Virginia, Forenede Stater, 24014
- Oncology and Hematology Associates of Southwest Virginia
-
South Hill, Virginia, Forenede Stater, 23970
- Community Memorial Health Center
-
Virginia Beach, Virginia, Forenede Stater, 23454
- Peninsula Cancer Institute-Cancer Specialists of Tidewater
-
Williamsburg, Virginia, Forenede Stater, 23185
- Peninsula Cancer Institute-Williamsburg
-
Winchester, Virginia, Forenede Stater, 22601
- Shenandoah Oncology Associates PC
-
-
Washington
-
Anacortes, Washington, Forenede Stater, 98221
- Cancer Care Center at Island Hospital
-
Auburn, Washington, Forenede Stater, 98002
- Auburn Regional Medical Center
-
Bellevue, Washington, Forenede Stater, 98004
- Overlake Hospital Medical Center
-
Bellingham, Washington, Forenede Stater, 98225
- PeaceHealth Saint Joseph Medical Center
-
Bremerton, Washington, Forenede Stater, 98310
- Harrison Medical Center
-
Bremerton, Washington, Forenede Stater, 98310
- Harrison Bremerton Hematology and Oncology
-
Burien, Washington, Forenede Stater, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, Forenede Stater, 98531
- Providence Centralia Hospital
-
Edmonds, Washington, Forenede Stater, 98026
- Swedish Medical Center-Edmonds
-
Edmonds, Washington, Forenede Stater, 98026
- Puget Sound Cancer Center
-
Everett, Washington, Forenede Stater, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Forenede Stater, 98003
- Saint Francis Hospital
-
Issaquah, Washington, Forenede Stater, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Forenede Stater, 99336
- Columbia Basin Hematology and Oncology PLLC
-
Kirkland, Washington, Forenede Stater, 98034
- Cascade Cancer Center
-
Mount Vernon, Washington, Forenede Stater, 98274
- Skagit Valley Hospital
-
Mount Vernon, Washington, Forenede Stater, 98274
- Skagit Valley Hospital Regional Cancer Care Center
-
Olympia, Washington, Forenede Stater, 98506-5166
- Providence - Saint Peter Hospital
-
Poulsbo, Washington, Forenede Stater, 98370
- Harrison Poulsbo Hematology and Oncology
-
Puyallup, Washington, Forenede Stater, 98372
- Good Samaritan Community Hospital
-
Seattle, Washington, Forenede Stater, 98195
- University of Washington Medical Center
-
Seattle, Washington, Forenede Stater, 98109
- Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
-
Seattle, Washington, Forenede Stater, 98104
- Harborview Medical Center
-
Seattle, Washington, Forenede Stater, 98104
- Minor and James Medical PLLC
-
Seattle, Washington, Forenede Stater, 98122-4307
- Swedish Medical Center-First Hill
-
Seattle, Washington, Forenede Stater, 98112
- Group Health Cooperative
-
Seattle, Washington, Forenede Stater, 98109
- Group Health
-
Sedro-Woolley, Washington, Forenede Stater, 98284
- United General Hospital
-
Sequim, Washington, Forenede Stater, 98384
- Olympic Medical Cancer Care Center
-
Spokane, Washington, Forenede Stater, 99218
- Evergreen Hematology and Oncology PS
-
Spokane, Washington, Forenede Stater, 99202
- Cancer Care Northwest - Spokane South
-
Spokane, Washington, Forenede Stater, 99220
- Rockwood Clinic
-
Spokane, Washington, Forenede Stater, 99218
- Cancer Care Northwest
-
Spokane, Washington, Forenede Stater, 99204
- Rockwood Cancer Treatment Center
-
Tacoma, Washington, Forenede Stater, 98405
- Saint Joseph Medical Center
-
Tacoma, Washington, Forenede Stater, 98405
- Allenmore Hospital
-
Tacoma, Washington, Forenede Stater, 98415
- Multicare Health System
-
Tacoma, Washington, Forenede Stater, 98405
- Northwest CCOP
-
Tacoma, Washington, Forenede Stater, 98499
- Saint Clare Hospital
-
Vancouver, Washington, Forenede Stater, 98684
- Northwest Cancer Specialists
-
Vancouver, Washington, Forenede Stater, 98686
- Legacy Salmon Creek Hospital
-
Vancouver, Washington, Forenede Stater, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Forenede Stater, 99362
- Providence Saint Mary Regional Cancer Center
-
Wenatchee, Washington, Forenede Stater, 98801
- Wenatchee Valley Medical Center
-
Yakima, Washington, Forenede Stater, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
-
West Virginia
-
Charleston, West Virginia, Forenede Stater, 25304
- West Virginia University Charleston
-
Huntington, West Virginia, Forenede Stater, 25701
- Edwards Comprehensive Cancer Center
-
Martinsburg, West Virginia, Forenede Stater, 25401
- City Hospital
-
Morgantown, West Virginia, Forenede Stater, 26506
- West Virginia University
-
Princeton, West Virginia, Forenede Stater, 24740
- Princeton Community Hospital
-
Wheeling, West Virginia, Forenede Stater, 26003
- Wheeling Hospital
-
-
Wisconsin
-
Antigo, Wisconsin, Forenede Stater, 54409
- Langlade Hospital and Cancer Center
-
Appleton, Wisconsin, Forenede Stater, 54911-3496
- Fox Valley Hematology and Oncology
-
Chippewa Falls, Wisconsin, Forenede Stater, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Eau Claire, Wisconsin, Forenede Stater, 54702
- Midelfort Clinic-Clairemont Campus
-
Eau Claire, Wisconsin, Forenede Stater, 54703
- Mayo Clinic Health System Eau Claire Hospital - Luther Campus
-
Green Bay, Wisconsin, Forenede Stater, 54301
- Bellin Memorial Hospital
-
Green Bay, Wisconsin, Forenede Stater, 54301
- Saint Vincent Hospital
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Green Bay Oncology Limited at Saint Mary's Hospital
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Saint Mary's Hospital
-
Green Bay, Wisconsin, Forenede Stater, 54301-3526
- Green Bay Oncology at Saint Vincent Hospital
-
Green Bay, Wisconsin, Forenede Stater, 54311-6519
- Aurora BayCare Medical Center
-
Janesville, Wisconsin, Forenede Stater, 53547
- Mercy Health System
-
Johnson Creek, Wisconsin, Forenede Stater, 53038
- UW Cancer Center Johnson Creek
-
La Crosse, Wisconsin, Forenede Stater, 54601
- Mayo Clinic Health System-Franciscan Healthcare
-
La Crosse, Wisconsin, Forenede Stater, 54601
- Gundersen Lutheran
-
Madison, Wisconsin, Forenede Stater, 53792
- University of Wisconsin Hospital and Clinics
-
Madison, Wisconsin, Forenede Stater, 53717
- Dean Hematology and Oncology Clinic
-
Manitowoc, Wisconsin, Forenede Stater, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Forenede Stater, 54143
- Bay Area Medical Center
-
Marinette, Wisconsin, Forenede Stater, 54143
- Vince Lombardi Cancer Clinic-Marinette
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Clinic
-
Milwaukee, Wisconsin, Forenede Stater, 53226
- Froedtert and the Medical College of Wisconsin
-
Minocqua, Wisconsin, Forenede Stater, 54548
- Marshfield Clinic-Minocqua Center
-
Mukwonago, Wisconsin, Forenede Stater, 53149
- D N Greenwald Center
-
New Richmond, Wisconsin, Forenede Stater, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Forenede Stater, 53066-3896
- Oconomowoc Memorial Hospital-ProHealth Care Inc
-
Oconto Falls, Wisconsin, Forenede Stater, 54154
- Green Bay Oncology - Oconto Falls
-
Oshkosh, Wisconsin, Forenede Stater, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Rhinelander, Wisconsin, Forenede Stater, 54501
- Marshfield Clinic at James Beck Cancer Center
-
Rice Lake, Wisconsin, Forenede Stater, 54868
- Marshfield Clinic-Rice Lake Center
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- Saint Nicholas Hospital
-
Stevens Point, Wisconsin, Forenede Stater, 54481
- Marshfield Clinic Cancer Care at Saint Michael's Hospital
-
Sturgeon Bay, Wisconsin, Forenede Stater, 54235
- Green Bay Oncology - Sturgeon Bay
-
Summit, Wisconsin, Forenede Stater, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Forenede Stater, 54241
- Vince Lombardi Cancer Clinic
-
Waukesha, Wisconsin, Forenede Stater, 53188
- Waukesha Memorial Hospital - ProHealth Care
-
Wausau, Wisconsin, Forenede Stater, 54401
- Aspirus Regional Cancer Center
-
Wausau, Wisconsin, Forenede Stater, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, Forenede Stater, 53226
- Aurora Cancer Care-Milwaukee West
-
Weston, Wisconsin, Forenede Stater, 54476
- Marshfield Clinic - Weston Center
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Riverview Hospital
-
-
Wyoming
-
Casper, Wyoming, Forenede Stater, 82609
- Rocky Mountain Oncology
-
Sheridan, Wyoming, Forenede Stater, 82801
- Welch Cancer Center
-
-
-
-
-
San Juan, Puerto Rico, 00936
- San Juan City Hospital
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år og ældre (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Kvinde
Beskrivelse
Inklusionskriterier:
- Patienten skal have en Eastern Cooperative Oncology Group (ECOG) præstationsstatus på 0 eller 1.
- Tumoren skal være unilateralt invasivt adenokarcinom i brystet ved histologisk undersøgelse.
- Brystkræften skal være Human Epidermal Growth Factor Receptor 2 (HER2)-negativ baseret på nuværende American Society of Clinical Oncology (ASCO)/CAP-retningslinje-anbefalinger for human epidermal vækstfaktorreceptor 2-test i brystkræft. Hvis resultatet af in situ hybridiseringstesten (FISH, chromagen in situ hybridisering [CISH] eller andet) er tvetydigt, er patienten kvalificeret, hvis der ikke er nogen plan om at administrere HER2-målrettet behandling.
Alle følgende iscenesættelseskriterier skal opfyldes i henhold til American Joint Committee on Cancer (AJCC) kriterier:
- Ved patologisk evaluering skal primær tumor være pT1-3;
- Ved patologisk evaluering skal ipsilaterale noder være pN0, pN1 (pN1mi, pN1a, pN1b, pN1c), pN2a, pN3a eller pN3b.
- Hvis pN0, skal mindst et af følgende kriterier være opfyldt:
- ER negativ og PgR negativ; eller
- Patologisk tumorstørrelse større end 2,0 cm; eller
- T1c (patologisk tumorstørrelse større end 1,0 cm, men mindre end eller lig med 2,0 cm) og ER-positiv (PgR-status kan være positiv eller negativ) og enten grad 3 histologi eller Oncotype DX®-tilbagefaldsscore på større end eller lig med 25.
- Patienterne skal have gennemgået enten total mastektomi eller brystbevarende operation (lumpektomi).
- For patienter, der gennemgår lumpektomi, skal marginerne af den resekerede prøve være histologisk fri for invasiv tumor og ductal carcinoma in situ (DCIS) som bestemt af den lokale patolog. Hvis patologisk undersøgelse viser tumor ved resektionslinjen, skal der udføres yderligere operative procedurer for at opnå klare marginer. Hvis tumor stadig er til stede ved den resekerede margin efter re-excision(er), skal patienten gennemgå total mastektomi for at være berettiget. (Patienter med marginer positive for lobulært karcinom in situ [LCIS] er kvalificerede uden yderligere resektion.)
- For patienter, der gennemgår mastektomi, skal marginerne være histologisk fri for invasiv tumor og DCIS.
Patienter skal have gennemført en af følgende procedurer til evaluering af patologisk nodalstatus:
- Sentinel lymfadenektomi alene, hvis patologisk nodal stadieinddeling baseret på sentinel lymfadenektomi er pN0, pN1mi eller pN1b;
- Sentinel-lymfadenektomi alene, hvis patologisk nodalstadieinddeling baseret på sentinel-lymfadenektomi er pN1a begrænset til 1 eller 2 positive knuder, og primær tumor er T1 eller T2 ved patologisk evaluering;
- Sentinel lymfadenektomi efterfulgt af fjernelse af yderligere non-sentinel lymfeknuder, hvis sentinel node (SN) er positiv; eller
- Aksellymfadenektomi med eller uden SN-isoleringsprocedure.
- Intervallet mellem den sidste operation for brystkræft (behandling eller stadieinddeling) og randomisering må ikke være mere end 84 dage.
- Patienter skal have udført ER-analyse på den primære tumor før randomisering. Brystkræft skal vurderes for ER-status i henhold til gældende ASCO/CAP-retningslinjer for testning af hormonreceptorer. Hvis negativ for ER, skal vurdering af PgR også udføres i henhold til gældende ASCO/CAP Guideline Recommendations for hormonreceptortestning. (Enten en kernebiopsi eller kirurgisk resektionsprøve kan bruges til ER/PgR-testning.)
De seneste postoperative blodtællinger, udført inden for 6 uger før randomisering, skal opfylde følgende kriterier:
- absolut neutrofiltal (ANC) skal være større end eller lig med 1200/mm3;
- trombocyttallet skal være større end eller lig med 100.000/mm3; og
- hæmoglobin skal være større end eller lig med 10 g/dL.
Følgende kriterier for bevis for tilstrækkelig leverfunktion skal være opfyldt baseret på resultaterne af de seneste postoperative test udført inden for 6 uger før randomisering:
- total bilirubin skal være mindre end eller lig med øvre normalgrænse (ULN) for laboratoriet, medmindre patienten har en bilirubinstigning større end ULN til 1,5 x ULN på grund af Gilberts sygdom eller lignende syndrom, der involverer langsom konjugering af bilirubin; og
- alkalisk fosfatase skal være mindre end eller lig med 2,5 x ULN for laboratoriet; og
- aspartattransaminase (AST) skal være mindre end eller lig med 1,5 x ULN for laboratoriet.
- Alkalisk fosfatase og AST må ikke begge være større end ULN. For eksempel, hvis den alkaliske fosfatase er større end ULN, men mindre end eller lig med 2,5 x ULN, skal AST være mindre end eller lig med ULN. Hvis AST er større end ULN, men mindre end eller lig med 1,5 x ULN, skal den alkaliske fosfatase være mindre end eller lig med ULN.
- Bemærk: Hvis alaninaminotransferase (ALT) udføres i stedet for AST (pr. institutions standardpraksis), skal ALT-værdien være mindre end eller lig med 1,5 x ULN; hvis begge blev udført, skal AST være mindre end eller lig med 1,5 x ULN.
- Patienter med ASAT eller alkalisk fosfatase højere end ULN er berettiget til at blive inkluderet i undersøgelsen, hvis leverbilleddannelse (CT, MRI, PET-CT eller PET-skanning udført inden for 90 dage før randomisering) ikke viser metastatisk sygdom og kravene til tilstrækkelig leverfunktion. funktion som beskrevet ovenfor er opfyldt.
- Patienter med alkalisk fosfatase, der er større end ULN, men mindre end eller lig med 2,5 x ULN, er berettiget til at blive inkluderet i undersøgelsen, hvis en knoglescanning, PET-CT-scanning eller PET-scanning udført inden for 90 dage før randomisering ikke viser metastatisk sygdom .
- Det seneste postoperative serumkreatinin udført inden for 6 uger før randomisering skal være mindre end eller lig med ULN for laboratoriet.
- Vurdering af venstre ventrikel ejektionsfraktion (LVEF) ved 2-D ekkokardiogram eller multigated acquisition (MUGA) scanning skal udføres inden for 90 dage før randomisering. LVEF skal være større end eller lig med 50 % uanset anlæggets nedre normalgrænse (LLN). (Hvis faciliteten, der udfører vurderingen, ikke har rapporteret LVEF som et helt tal, skal decimaler, der er rapporteret som større end eller lig med 5, rundes op, og decimaler, der rapporteres som mindre end 5, skal rundes ned.)
Ekskluderingskriterier:
Patienter med en eller flere af følgende tilstande er ikke kvalificerede til denne undersøgelse.
- T4-tumorer inklusive inflammatorisk brystkræft.
- Endelige kliniske eller radiologiske tegn på metastatisk sygdom. (Brystbilleddannelse [obligatorisk for alle patienter] og anden billeddannelse [hvis påkrævet] skal være udført inden for 90 dage før randomisering.)
- Synkron eller tidligere kontralateral invasiv brystkræft. (Patienter med synkrone og/eller tidligere kontralaterale DCIS er berettigede.)
- Enhver historie med ipsilateral invasiv brystkræft eller ipsilateral DCIS.
- Anamnese med ikke-brystmaligniteter inden for 5 år før randomisering, bortset fra følgende: carcinom in situ i livmoderhalsen, kolorektal carcinom in situ, melanom in situ og basalcelle- og pladecellekarcinomer i huden.
- Tidligere behandling med antracykliner eller taxaner for enhver malignitet.
- Kemoterapi administreret for den aktuelt diagnosticerede brystkræft før randomisering.
- Fortsat endokrin behandling såsom raloxifen eller tamoxifen (eller anden SERM) eller en aromatasehæmmer. Patienter er berettigede, hvis disse lægemidler seponeres før randomisering.
- Enhver kønshormonbehandling, f.eks. p-piller, hormonsubstitutionsterapi i æggestokkene. Patienter er berettigede, hvis disse lægemidler seponeres før randomisering.
- Kendt aktiv hepatitis B eller hepatitis C med unormale leverfunktionstests.
Hjertesygdom (historie af og/eller aktiv sygdom), der ville udelukke brugen af de lægemidler, der er inkluderet i behandlingsregimerne. Dette omfatter, men er ikke begrænset til:
- Aktiv hjertesygdom
- angina pectoris, der kræver brug af anti-anginal medicin;
- ventrikulære arytmier med undtagelse af benigne præmature ventrikulære kontraktioner;
- supraventrikulære og nodale arytmier, der kræver en pacemaker eller ikke kontrolleres med medicin;
- ledningsabnormitet, der kræver en pacemaker;
- klapsygdom med dokumenteret kompromittering af hjertefunktionen;
- symptomatisk perikarditis.
- Anamnese med hjertesygdom
- myokardieinfarkt dokumenteret af forhøjede hjerteenzymer eller vedvarende regionale vægabnormiteter ved vurdering af venstre ventrikelfunktion;
- historie med dokumenteret kongestiv hjertesvigt (CHF);
- dokumenteret kardiomyopati.
- Helbryststrålebehandling (RT) før randomisering eller delvis bryst-RT, der ikke kan afsluttes på eller før randomiseringsdatoen.
- Iboende lungesygdom, der resulterer i dyspnø.
- Ustabil diabetes mellitus.
- Aktiv infektion eller kronisk infektion, der kræver suppressive antibiotika.
- Anamnese med et større organallotransplantat eller tilstand, der kræver kronisk immunsuppression, f.eks. nyre-, lever-, lunge-, hjerte-, knoglemarvstransplantation eller autoimmune sygdomme. (Patienter, der har modtaget hornhindetransplantationer, kadaverhud eller knogletransplantationer er berettigede.)
- Nervesystemlidelse (paræstesi, perifer motorisk neuropati eller perifer sensorisk neuropati) større end eller lig med grad 2 ifølge NCI CTCAE v4.0.
- Forhold, der ville forbyde administration af kortikosteroider.
- Kronisk daglig behandling med kortikosteroider (dosis større end eller lig med 10 mg/dag methylprednisolonækvivalent) (eksklusive inhalerede steroider).
- Anamnese med overfølsomhedsreaktion på lægemidler formuleret med polysorbat 80.
- Graviditet eller amning på tidspunktet for studiestart. (Bemærk: Graviditetstest skal udføres inden for 2 uger før randomisering i henhold til institutionelle standarder for kvinder i den fødedygtige alder.)
- Anden ikke-malign systemisk sygdom, der ville forhindre patienten i at modtage undersøgelsesbehandling eller ville forhindre nødvendig opfølgning.
- Psykiatriske eller vanedannende lidelser eller andre tilstande, der efter undersøgerens opfattelse vil forhindre patienten i at opfylde undersøgelseskravene.
- Brug af ethvert forsøgsprodukt inden for 30 dage før randomisering.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Aktiv komparator: Arm 1: Antracyklin-baseret kemoterapi
4 antracyklin-baserede kemoterapi-regimer (regimer A, B, C eller D). Regime A (TAC): 75 mg/m2 docetaxel (T) + 50 mg/m2 doxorubicin (A) + 500 mg/m2 cyclophosphamid (C) IV hver 3. uge i 6 cyklusser. Regime B (AC derefter WP): 60 mg/m2 doxorubicin (A) + 600 mg/m2 cyclophosphamid (C) hver 3. uge i 4 cyklusser efterfulgt af ugentlig paclitaxel (WP) 80 mg/m2 IV hver uge i 12 doser. Regime C (DD AC derefter WP): 60 mg/m2 doxorubicin + 600 mg/m2 cyclophosphamid hver 2. uge i 4 cyklusser efterfulgt af ugentlig paclitaxel 80 mg/m2 IV hver uge i 12 doser. Regime D (DD AC derefter DD P): 60 mg/m2 doxorubicin + 600 mg/m2 cyclophosphamid hver 2. uge i 4 cyklusser efterfulgt af paclitaxel (P) 175 mg/m2 IV hver 2. uge i 4 cyklusser. |
Andre navne:
|
|
Aktiv komparator: Arm 2: docetaxel + cyclophosphamid
TC: 75 mg/m2 docetaxel og 600 mg/m2 cyclophosphamid IV hver 3. uge i 6 cyklusser
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Invasiv sygdomsfri overlevelse (IDFS)
Tidsramme: Vurderet før hver kemoterapicyklus, 3-4 uger efter afslutning af kemoterapi, hver 6. måned gennem 5 år og årlige år 6-10.
|
Tiden til lokalt recidiv efter mastektomi, invasivt lokalt recidiv i det ipsilaterale bryst efter lumpektomi, regionalt recidiv, fjernt recidiv, invasiv kontralateral brystkræft, anden primær cancer (bortset fra plade- eller basalcellekarcinom i huden, melanom in situ, karcinom i situ af livmoderhalsen, kolorektalt carcinom in situ eller lobulært carcinom in situ af brystet), eller død af en hvilken som helst årsag før recidiv eller anden primær cancer.
|
Vurderet før hver kemoterapicyklus, 3-4 uger efter afslutning af kemoterapi, hver 6. måned gennem 5 år og årlige år 6-10.
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Sygdomsfri overlevelse (DFS-DCIS)
Tidsramme: Vurderet før hver kemoterapicyklus, 3-4 uger efter afslutning af kemoterapi, hver 6. måned gennem 5 år og årlige år 6-10.
|
Tiden til lokalt recidiv efter mastektomi, lokalt recidiv i det ipsilaterale bryst efter lumpektomi (invasiv eller ikke-invasiv), regionalt recidiv, fjernt recidiv, kontralateral brystkræft (invasiv eller ikke-invasiv), anden primær cancer (bortset fra pladeepitel eller basal cancer) cellekarcinom i huden, melanom in situ, carcinom in situ i livmoderhalsen, kolorektal carcinom in situ eller lobular carcinom in situ i brystet), eller død af enhver årsag før tilbagefald eller anden primær cancer.
|
Vurderet før hver kemoterapicyklus, 3-4 uger efter afslutning af kemoterapi, hver 6. måned gennem 5 år og årlige år 6-10.
|
|
Samlet overlevelse (OS)
Tidsramme: Vurderet før hver kemoterapicyklus, 3-4 uger efter afslutning af kemoterapi, hver 6. måned gennem 5 år og årlige år 6-10.
|
Tid fra randomisering til død uanset årsag.
|
Vurderet før hver kemoterapicyklus, 3-4 uger efter afslutning af kemoterapi, hver 6. måned gennem 5 år og årlige år 6-10.
|
|
Gentagelsesfrit interval (RFI)
Tidsramme: Vurderet før hver kemoterapicyklus, 3-4 uger efter afslutning af kemoterapi, hver 6. måned gennem 5 år og årlige år 6-10.
|
Tid fra randomisering til lokal, regional eller fjern gentagelse.
|
Vurderet før hver kemoterapicyklus, 3-4 uger efter afslutning af kemoterapi, hver 6. måned gennem 5 år og årlige år 6-10.
|
|
Toksicitet af hver kur
Tidsramme: Vurderet før hver kemoterapicyklus, 3-4 uger efter afslutning af kemoterapi, hver 6. måned gennem 5 år og årlige år 6-10.
|
Hyppigheder af uønskede hændelser kategoriseret ved hjælp af NCI Common Terminology Criteria for Adverse Events (CTCAE) v4.0.
|
Vurderet før hver kemoterapicyklus, 3-4 uger efter afslutning af kemoterapi, hver 6. måned gennem 5 år og årlige år 6-10.
|
|
Molekylære prædiktorer for effektivitet
Tidsramme: Vævsprøve opsamlet på tidspunktet for operationen
|
At udvikle prædiktive markører for gavn af doxorubicin.
|
Vævsprøve opsamlet på tidspunktet for operationen
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. april 2012
Primær færdiggørelse (Forventet)
1. maj 2022
Studieafslutning (Forventet)
1. november 2023
Datoer for studieregistrering
Først indsendt
6. marts 2012
Først indsendt, der opfyldte QC-kriterier
6. marts 2012
Først opslået (Skøn)
8. marts 2012
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
14. april 2022
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
13. april 2022
Sidst verificeret
1. april 2022
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
- Hudsygdomme
- Neoplasmer
- Neoplasmer efter sted
- Brystsygdomme
- Brystneoplasmer
- Lægemidlers fysiologiske virkninger
- Molekylære mekanismer for farmakologisk virkning
- Enzymhæmmere
- Antirheumatiske midler
- Antineoplastiske midler
- Immunsuppressive midler
- Immunologiske faktorer
- Tubulin modulatorer
- Antimitotiske midler
- Mitose modulatorer
- Antineoplastiske midler, Alkylering
- Alkyleringsmidler
- Myeloablative agonister
- Antineoplastiske midler, fytogene
- Topoisomerase II-hæmmere
- Topoisomerasehæmmere
- Antibiotika, antineoplastisk
- Docetaxel
- Cyclofosfamid
- Paclitaxel
- Doxorubicin
Andre undersøgelses-id-numre
- NSABP-B-49
- NCI-2012-00701 (Registry Identifier: CTRP (Clinical Trials Reporting Program))
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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