Docetaxel og cyklofosfamid sammenlignet med antracyklinbasert kjemoterapi ved behandling av kvinner med HER2-negativ brystkreft
13. april 2022 oppdatert av: NSABP Foundation Inc
En fase III klinisk studie som sammenligner kombinasjonen av docetaxel pluss cyklofosfamid med antracyklinbaserte kjemoterapiregimer for kvinner med nodepositiv eller høyrisikoknute-negativ, HER2-negativ brystkreft
BAKGRUNN: Legemidler som brukes i cellegift virker på ulike måter for å stoppe veksten av brystkreftceller, enten ved å drepe cellene eller ved å hindre dem i å dele seg. Å gi stoffene i forskjellige kombinasjoner kan drepe flere brystkreftceller. Å gi kombinasjonskjemoterapi etter operasjonen kan drepe eventuelle tumorceller som er igjen etter operasjonen.
FORMÅL: Denne randomiserte fase III-studien studerer forskjellige kombinasjons-kjemoterapiregimer og deres bivirkninger og sammenligner hvor godt de fungerer i behandling av kvinner med ikke-metastatisk brystkreft.
Studieoversikt
Status
Aktiv, ikke rekrutterende
Forhold
Intervensjon / Behandling
Detaljert beskrivelse
MÅL:
Hoved
- For å avgjøre om docetaksel- og cyklofosfamid-regimet (TC) ikke er dårligere enn de antracyklinbaserte kjemoterapiregimene når det gjelder invasiv sykdomsfri overlevelse (DFS) ved å kombinere B-49-data med docetaksel, doksorubicin og cyklofosfamid (TAC) og TC-armer til NSABP B-46-I/US Oncology Research, Inc.(USOR) 07132 og dataene fra USOR 06-090.
Sekundær
- For å bestemme frekvensen av DFS-duktalt karsinom in situ (DCIS) for TC- og antracyklinbaserte kjemoterapiregimer.
- For å bestemme rater for total overlevelse (OS) for TC- og antracyklinbaserte kjemoterapiregimer.
- For å bestemme frekvensen av tilbakefallsfritt intervall (RFI) for TC- og antracyklinbaserte kjemoterapiregimer.
- For å evaluere toksisiteten knyttet til hver av regimene.
- For å bestemme rollen til TOP2A i prognose og prediksjon av grad av nytte av antracyklinbasert kjemoterapi fremfor TC. (utforskende)
- Å utvikle prediktive markører for nytte av doksorubicin. (utforskende)
OVERSIKT: Dette er en randomisert multisenterstudie. Pasientene er stratifisert etter antall positive noder (0 vs 1-3 vs 4-9 vs 10+) og hormonreseptorstatus (østrogenreseptor [ER] og/eller progesteronreseptor [PgR] positiv vs ER og PgR negativ). Pasientene er randomisert til 1 av 2 behandlingsarmer.
Studietype
Intervensjonell
Registrering (Faktiske)
1871
Fase
- Fase 3
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiesteder
-
-
Alaska
-
Anchorage, Alaska, Forente stater, 99508
- Providence Alaska Medical Center
-
-
Arizona
-
Phoenix, Arizona, Forente stater, 85016
- Arizona Oncology Associates-Biltmore Cancer Center
-
Scottsdale, Arizona, Forente stater, 85258
- Premiere Oncology of Arizona
-
Sedona, Arizona, Forente stater, 86336
- Sedona Medical Center
-
Tucson, Arizona, Forente stater, 85704
- Arizona Oncology Associates
-
-
Arkansas
-
Jonesboro, Arkansas, Forente stater, 72401
- NEA Baptist Clinic-Matthews
-
-
California
-
Anaheim, California, Forente stater, 92807
- Kaiser Anaheim Medical Center
-
Antioch, California, Forente stater, 94531
- Kaiser Permanente-Deer Valley Medical Center
-
Baldwin Park, California, Forente stater, 91706
- Kaiser Permanente Medical Group - Baldwin Park
-
Bellflower, California, Forente stater, 90706
- Kaiser Foundation Hospital
-
Burbank, California, Forente stater, 91505
- Providence Saint Joseph Medical Center
-
Castro Valley, California, Forente stater, 94546
- East Bay Radiation Oncology Center
-
Castro Valley, California, Forente stater, 94546
- Valley Medical Oncology Consultants-Castro Valley
-
Dublin, California, Forente stater, 94568
- Epic Care-Dublin
-
Fairfield, California, Forente stater, 94533
- Northbay Cancer Center
-
Fontana, California, Forente stater, 92335
- Kaiser Permanente Hospital
-
Fremont, California, Forente stater, 94538
- Valley Medical Oncology Consultants-Fremont
-
Fremont, California, Forente stater, 94538
- Washington Hospital
-
Fremont, California, Forente stater, 94538
- Kaiser Permanente, Fremont
-
Fresno, California, Forente stater, 93720
- Kaiser Permanente
-
Fresno, California, Forente stater, 93720
- California Cancer Center - North Fresno
-
Harbor City, California, Forente stater, 90710
- Kaiser Permanente - Harbor City
-
Hayward, California, Forente stater, 94545
- Kaiser Permanente, Hayward
-
Irvine, California, Forente stater, 92618
- Southern California Permanente Medical Group
-
La Jolla, California, Forente stater, 92093
- UC San Diego Moores Cancer Center
-
Long Beach, California, Forente stater, 90806
- Long Beach Memorial Medical Center-Todd Cancer Institute
-
Los Angeles, California, Forente stater, 90048
- Cedars-Sinai Medical Center
-
Los Angeles, California, Forente stater, 90027
- Kaiser Permanente Los Angeles Medical Center
-
Los Angeles, California, Forente stater, 90027
- Kaiser Permanente
-
Los Angeles, California, Forente stater, 90034
- Kaiser Permanente-West Los Angeles
-
Martinez, California, Forente stater, 94553-3156
- Contra Costa Regional Medical Center
-
Modesto, California, Forente stater, 95355
- Memorial Medical Center
-
Modesto, California, Forente stater, 95356
- Kaiser Permanente-Modesto
-
Monterey, California, Forente stater, 93940
- Community Hospital of Monterey Peninsula
-
Mountain View, California, Forente stater, 94040
- El Camino Hospital
-
Oakland, California, Forente stater, 94611
- Kaiser Permanente-Oakland
-
Oakland, California, Forente stater, 94609
- Alta Bates Summit Medical Center - Summit Campus
-
Oakland, California, Forente stater, 94602
- Highland General Hospital
-
Oakland, California, Forente stater, 94609
- Bay Area Breast Surgeons Inc
-
Oakland, California, Forente stater, 94609
- Larry G Strieff MD Medical Corporation
-
Oakland, California, Forente stater, 94609
- Tom K Lee Inc
-
Oakland, California, Forente stater, 94609
- Bay Area Tumor Institute
-
Oakland, California, Forente stater, 94612
- Epic Care-Oakland
-
Palm Springs, California, Forente stater, 92262
- Desert Regional Medical Center
-
Panorama City, California, Forente stater, 91402
- Kaiser Permanente - Panorama City
-
Paradise, California, Forente stater, 95969
- Feather River Cancer Center
-
Pleasant Hill, California, Forente stater, 94523
- East Bay Medical Oncology Hematology Medical Associates Inc-Pleasant Hill
-
Pomona, California, Forente stater, 91767
- Pomona Valley Hospital Medical Center
-
Redwood City, California, Forente stater, 94063
- Kaiser Permanente-Redwood City
-
Richmond, California, Forente stater, 94801
- Kaiser Permanente-Richmond
-
Riverside, California, Forente stater, 92505
- Kaiser Permanente Medical Center
-
Roseville, California, Forente stater, 95661
- Kaiser Permanente-Roseville
-
Sacramento, California, Forente stater, 95823
- Kaiser Permanente-South Sacramento
-
Sacramento, California, Forente stater, 95825
- Kaiser Permanente - Sacramento
-
Saint Helena, California, Forente stater, 94574
- Saint Helena Hospital
-
San Diego, California, Forente stater, 92134
- Naval Medical Center -San Diego
-
San Diego, California, Forente stater, 92120
- Kaiser Permanente at San Diego
-
San Francisco, California, Forente stater, 94115
- Kaiser Permanente-San Francisco
-
San Jose, California, Forente stater, 95119
- Kaiser Permanente-Santa Teresa-San Jose
-
San Jose, California, Forente stater, 95128
- Santa Clara Valley Medical Center
-
San Marcos, California, Forente stater, 92069
- Kaiser Permanente Health Care
-
San Pablo, California, Forente stater, 94806
- Doctors Medical Center- JC Robinson Regional Cancer Center
-
San Rafael, California, Forente stater, 94903
- Kaiser Permanente-San Rafael
-
Santa Clara, California, Forente stater, 95051
- Kaiser Permanente Medical Center - Santa Clara
-
Santa Rosa, California, Forente stater, 95403
- Kaiser Permanente-Santa Rosa
-
South San Francisco, California, Forente stater, 94080
- Kaiser Permanente-South San Francisco
-
Stanford, California, Forente stater, 94305
- Stanford University Hospitals and Clinics
-
Stockton, California, Forente stater, 95210
- Kaiser Permanente-Stockton
-
Vacaville, California, Forente stater, 95688
- Kaiser Permanente Medical Center-Vacaville
-
Vallejo, California, Forente stater, 94589
- Kaiser Permanente-Vallejo
-
Walnut Creek, California, Forente stater, 94596
- Kaiser Permanente-Walnut Creek
-
Whittier, California, Forente stater, 90602
- Presbyterian Intercommunity Hospital
-
Woodland Hills, California, Forente stater, 91367
- Kaiser Permanente
-
-
Colorado
-
Aurora, Colorado, Forente stater, 80012
- The Medical Center of Aurora
-
Boulder, Colorado, Forente stater, 80301
- Boulder Community Hospital
-
Colorado Springs, Colorado, Forente stater, 80907
- Penrose-Saint Francis Healthcare
-
Denver, Colorado, Forente stater, 80210
- Porter Adventist Hospital
-
Denver, Colorado, Forente stater, 80205
- Kaiser Permanente-Franklin
-
Denver, Colorado, Forente stater, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
-
Denver, Colorado, Forente stater, 80220
- Rose Medical Center
-
Denver, Colorado, Forente stater, 80218
- Exempla Saint Joseph Hospital
-
Denver, Colorado, Forente stater, 80224-2522
- Colorado Cancer Research Program CCOP
-
Denver, Colorado, Forente stater, 80204
- Saint Anthony Central Hospital
-
Englewood, Colorado, Forente stater, 80110
- Swedish Medical Center
-
Fort Collins, Colorado, Forente stater, 80524
- Poudre Valley Hospital
-
Fort Collins, Colorado, Forente stater, 80528
- Front Range Cancer Specialists
-
Greeley, Colorado, Forente stater, 80631
- North Colorado Medical Center
-
Lafayette, Colorado, Forente stater, 80026
- Kaiser Permanente-Rock Creek
-
Littleton, Colorado, Forente stater, 80122
- Littleton Adventist Hospital
-
Lone Tree, Colorado, Forente stater, 80124
- Sky Ridge Medical Center
-
Longmont, Colorado, Forente stater, 80501
- Longmont United Hospital
-
Loveland, Colorado, Forente stater, 80539
- McKee Medical Center
-
Parker, Colorado, Forente stater, 80138
- Parker Adventist Hospital
-
Pueblo, Colorado, Forente stater, 81004
- Saint Mary Corwin Medical Center
-
Thornton, Colorado, Forente stater, 80229
- North Suburban Medical Center
-
Wheat Ridge, Colorado, Forente stater, 80033
- Exempla Lutheran Medical Center
-
-
Connecticut
-
Farmington, Connecticut, Forente stater, 06030
- University of Connecticut
-
Hartford, Connecticut, Forente stater, 06102
- Hartford Hospital
-
Hartford, Connecticut, Forente stater, 06105
- Saint Francis Hospital and Medical Center
-
Manchester, Connecticut, Forente stater, 06040
- Manchester Memorial Hospital
-
Meriden, Connecticut, Forente stater, 06451
- Midstate Medical Center
-
Middletown, Connecticut, Forente stater, 06457
- Middlesex Hospital
-
New Britain, Connecticut, Forente stater, 06050
- The Hospital of Central Connecticut
-
Stamford, Connecticut, Forente stater, 06904
- Stamford Hospital
-
-
Delaware
-
Dover, Delaware, Forente stater, 19901
- Bayhealth Medical Center at Kent General
-
Lewes, Delaware, Forente stater, 19958
- Beebe Medical Center
-
Newark, Delaware, Forente stater, 19718
- Christiana Care Health System-Christiana Hospital
-
Seaford, Delaware, Forente stater, 19973
- Nanticoke Memorial Hospital
-
-
District of Columbia
-
Washington, District of Columbia, Forente stater, 20010
- Washington Hospital Center
-
Washington, District of Columbia, Forente stater, 20057
- Lombardi Comprehensive Cancer Center at Georgetown University
-
Washington, District of Columbia, Forente stater, 20016
- Sibley Memorial Hospital
-
Washington, District of Columbia, Forente stater, 20002
- Kaiser Permanente-Capitol Hill Medical Center
-
Washington, District of Columbia, Forente stater, 20037
- George Washington University Medical Center
-
-
Florida
-
Clearwater, Florida, Forente stater, 33756
- Morton Plant Hospital
-
Fort Lauderdale, Florida, Forente stater, 33316
- Broward Health Medical Center
-
Fort Lauderdale, Florida, Forente stater, 33308
- Holy Cross Hospital
-
Jacksonville, Florida, Forente stater, 32207
- Edna Williams Cancer Center at the Baptist Cancer Institute
-
Jacksonville, Florida, Forente stater, 32204
- Saint Vincent's Medical Center
-
Jupiter, Florida, Forente stater, 33458
- Jupiter Medical Center
-
Lakeland, Florida, Forente stater, 33805
- Lakeland Regional Cancer Center
-
Lakeland, Florida, Forente stater, 33805
- The Watson Clinic
-
Miami, Florida, Forente stater, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
-
Miami, Florida, Forente stater, 33176
- Advanced Medical Specialties -North
-
Miami Beach, Florida, Forente stater, 33140
- Mount Sinai Medical Center CCOP
-
Ocala, Florida, Forente stater, 34471
- Ocala Oncology Center
-
Orlando, Florida, Forente stater, 32803
- Florida Hospital
-
Orlando, Florida, Forente stater, 32806
- M D Anderson Cancer Center- Orlando
-
Pensacola, Florida, Forente stater, 32504
- Sacred Heart Hospital
-
Pensacola, Florida, Forente stater, 32514
- Sacred Heart Medical Oncology Group - Davis Highway
-
-
Georgia
-
Atlanta, Georgia, Forente stater, 30309
- Piedmont Hospital
-
Augusta, Georgia, Forente stater, 30901
- Augusta Oncology Associates PC-Saint Sebastian
-
Columbus, Georgia, Forente stater, 31904
- John B Amos Cancer Center
-
Decatur, Georgia, Forente stater, 30033
- Dekalb Medical Center
-
Gainesville, Georgia, Forente stater, 30501
- Northeast Georgia Medical Center
-
Savannah, Georgia, Forente stater, 31403
- Memorial Health University Medical Center
-
Savannah, Georgia, Forente stater, 31405
- Saint Joseph's-Candler Health System
-
Valdosta, Georgia, Forente stater, 31603
- South Georgia Medical Center
-
-
Hawaii
-
'Aiea, Hawaii, Forente stater, 96701
- Kapiolani Medical Center at Pali Momi
-
'Aiea, Hawaii, Forente stater, 96701
- Oncare Hawaii Inc - Kapiolani Medical Center at Pali Momi
-
Honolulu, Hawaii, Forente stater, 96813
- Queen's Medical Center
-
Honolulu, Hawaii, Forente stater, 96813
- Straub Clinic and Hospital
-
Honolulu, Hawaii, Forente stater, 96817
- Kuakini Medical Center
-
Honolulu, Hawaii, Forente stater, 96826
- Kapiolani Medical Center for Women and Children
-
Honolulu, Hawaii, Forente stater, 96819
- Kaiser Permanente Moanalua Medical Center
-
Honolulu, Hawaii, Forente stater, 96813
- University of Hawaii
-
Honolulu, Hawaii, Forente stater, 96813
- Oncare Hawaii Inc-POB II
-
Honolulu, Hawaii, Forente stater, 96817-3169
- OnCare Hawaii-Liliha
-
Honolulu, Hawaii, Forente stater, 96817
- Oncare Hawaii Inc-Kuakini
-
Kailua, Hawaii, Forente stater, 96734
- Castle Medical Center
-
Lihue, Hawaii, Forente stater, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
-
-
Idaho
-
Boise, Idaho, Forente stater, 83712
- Saint Luke's Mountain States Tumor Institute
-
Boise, Idaho, Forente stater, 83706
- Saint Alphonsus Regional Medical Center
-
Fruitland, Idaho, Forente stater, 83619
- Saint Luke's Mountain States Tumor Institute - Fruitland
-
Lewiston, Idaho, Forente stater, 83501
- Saint Joseph Regional Medical Center
-
Meridian, Idaho, Forente stater, 83642
- Saint Luke's Mountain States Tumor Institute - Meridian
-
Meridian, Idaho, Forente stater, 83642
- Idaho Urologic Institute PA
-
Nampa, Idaho, Forente stater, 83686
- Saint Luke's Mountain States Tumor Institute - Nampa
-
Post Falls, Idaho, Forente stater, 83854
- Kootenai Cancer Center
-
Twin Falls, Idaho, Forente stater, 83301
- Saint Luke's Mountain States Tumor Institute-Twin Falls
-
-
Illinois
-
Aurora, Illinois, Forente stater, 60504
- Rush - Copley Medical Center
-
Bloomington, Illinois, Forente stater, 61701
- Saint Joseph Medical Center
-
Bloomington, Illinois, Forente stater, 61701
- Illinois CancerCare-Bloomington
-
Canton, Illinois, Forente stater, 61520
- Illinois CancerCare-Canton
-
Canton, Illinois, Forente stater, 61520
- Graham Hospital Association
-
Carthage, Illinois, Forente stater, 62321
- Illinois CancerCare-Carthage
-
Carthage, Illinois, Forente stater, 62321
- Memorial Hospital
-
Chicago, Illinois, Forente stater, 60611
- Northwestern University
-
Chicago, Illinois, Forente stater, 60612
- University of Illinois
-
Chicago, Illinois, Forente stater, 60608
- Mount Sinai Hospital Medical Center
-
Chicago, Illinois, Forente stater, 60640
- Weiss Memorial Hospital
-
Chicago, Illinois, Forente stater, 60612-3785
- John H Stroger Jr Hospital of Cook County
-
Decatur, Illinois, Forente stater, 62526
- Decatur Memorial Hospital
-
Eureka, Illinois, Forente stater, 61530
- Illinois CancerCare-Eureka
-
Eureka, Illinois, Forente stater, 61530
- Eureka Hospital
-
Evanston, Illinois, Forente stater, 60202
- Saint Francis Hospital
-
Evanston, Illinois, Forente stater, 60201
- Evanston CCOP-NorthShore University HealthSystem
-
Freeport, Illinois, Forente stater, 61032
- FHN Leonard C. Ferguson Cancer Center
-
Galesburg, Illinois, Forente stater, 61401
- Illinois CancerCare Galesburg
-
Galesburg, Illinois, Forente stater, 61401
- Medical and Surgical Specialists
-
Havana, Illinois, Forente stater, 62644
- Mason District Hospital
-
Havana, Illinois, Forente stater, 62644
- Illinois CancerCare-Havana
-
Highland Park, Illinois, Forente stater, 60035
- Hematology Oncology Associates of Illinois-Highland Park
-
Hinsdale, Illinois, Forente stater, 60521
- Hinsdale Hematology Oncology Associates Incorporated
-
Joliet, Illinois, Forente stater, 60435
- Joliet Oncology-Hematology Associates Limited
-
Kankakee, Illinois, Forente stater, 60901
- Presence Saint Mary's Hospital
-
Kewanee, Illinois, Forente stater, 61443
- Illinois CancerCare-Kewanee Clinic
-
La Grange, Illinois, Forente stater, 60525
- Adventist La Grange Memorial Hospital
-
Libertyville, Illinois, Forente stater, 60048
- North Shore Hematology Oncology
-
Macomb, Illinois, Forente stater, 61455
- Illinois CancerCare-Macomb
-
Macomb, Illinois, Forente stater, 61455
- Mcdonough District Hospital
-
Moline, Illinois, Forente stater, 61265
- Garneau, Stewart C MD (UIA Investigator)
-
Moline, Illinois, Forente stater, 61265
- Porubcin, Michael MD (UIA Investigator)
-
Moline, Illinois, Forente stater, 61265
- Spector, David MD (UIA Investigator)
-
Moline, Illinois, Forente stater, 61265
- Trinity Medical Center
-
Monmouth, Illinois, Forente stater, 61462
- Illinois CancerCare-Monmouth
-
Monmouth, Illinois, Forente stater, 61462
- Holy Family Medical Center
-
Mount Vernon, Illinois, Forente stater, 62864
- Good Samaritan Regional Medical Center
-
Naperville, Illinois, Forente stater, 60540
- Hematology Oncology Consultants Limited
-
Naperville, Illinois, Forente stater, 60540
- Edward Hospital/Cancer Center
-
Niles, Illinois, Forente stater, 60714
- Illinois Cancer Specialists-Niles
-
Normal, Illinois, Forente stater, 61761
- Community Cancer Center Foundation
-
Normal, Illinois, Forente stater, 61761
- Bromenn Regional Medical Center
-
Normal, Illinois, Forente stater, 61761
- Illinois CancerCare-Community Cancer Center
-
Normal, Illinois, Forente stater, 61761
- Mid-Illinois Hematology Oncology Associates
-
Oak Lawn, Illinois, Forente stater, 60453-2699
- Advocate Christ Medical Center
-
Ottawa, Illinois, Forente stater, 61350
- Illinois CancerCare-Ottawa Clinic
-
Ottawa, Illinois, Forente stater, 61350
- Ottawa Regional Hospital and Healthcare Center
-
Park Ridge, Illinois, Forente stater, 60068
- Advocate Lutheran General Hospital
-
Pekin, Illinois, Forente stater, 61554
- Pekin Cancer Treatment Center
-
Pekin, Illinois, Forente stater, 61603
- Illinois CancerCare-Pekin
-
Peoria, Illinois, Forente stater, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Forente stater, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, Forente stater, 61614
- Proctor Hospital
-
Peoria, Illinois, Forente stater, 61603
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Forente stater, 61615
- Illinois Oncology Research Association CCOP
-
Peru, Illinois, Forente stater, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Forente stater, 61354
- Illinois Valley Hospital
-
Princeton, Illinois, Forente stater, 61356
- Illinois CancerCare-Princeton
-
Princeton, Illinois, Forente stater, 61356
- Perry Memorial Hospital
-
River Forest, Illinois, Forente stater, 60305
- West Suburban Cancer Center
-
Rockford, Illinois, Forente stater, 61104
- Swedish American Hospital
-
Rockford, Illinois, Forente stater, 61107
- SwedishAmerican Regional Cancer Center/ACT
-
Skokie, Illinois, Forente stater, 60076
- Hematology Oncology Associates of Illinois - Skokie
-
Spring Valley, Illinois, Forente stater, 61362
- Illinois CancerCare-Spring Valley
-
Springfield, Illinois, Forente stater, 62781-0001
- Memorial Medical Center
-
Urbana, Illinois, Forente stater, 61801
- Carle Foundation - Carle Cancer Center
-
-
Indiana
-
Beech Grove, Indiana, Forente stater, 46107
- Saint Francis Hospital and Health Centers
-
Elkhart, Indiana, Forente stater, 46515
- Elkhart General Hospital
-
Elkhart, Indiana, Forente stater, 46514
- Michiana Hematology Oncology PC-Elkhart
-
Elkhart, Indiana, Forente stater, 46514-2098
- Elkhart Clinic
-
Fort Wayne, Indiana, Forente stater, 46845
- Fort Wayne Medical Oncology and Hematology Inc - State Boulevard
-
Indianapolis, Indiana, Forente stater, 46237
- Franciscan St. Francis Health
-
Indianapolis, Indiana, Forente stater, 46219
- Central Indiana Cancer Centers - Indianapolis
-
Kokomo, Indiana, Forente stater, 46904
- Community Howard Regional Health
-
La Porte, Indiana, Forente stater, 46350
- Indiana University Health La Porte Hospital
-
Lafayette, Indiana, Forente stater, 47904
- IU Health Arnett
-
Merrillville, Indiana, Forente stater, 46410
- Premier Oncology Hematology Associates
-
Michigan City, Indiana, Forente stater, 46360
- Saint Anthony Memorial Health Center
-
Mishawaka, Indiana, Forente stater, 46545-1470
- Saint Joseph Regional Medical Center-Mishawaka
-
Mishawaka, Indiana, Forente stater, 46545
- Cancer Care Partners LLC
-
Mishawaka, Indiana, Forente stater, 46545-1470
- Michiana Hematology Oncology PC-Mishawaka
-
Munster, Indiana, Forente stater, 46321
- The Community Hospital
-
Plymouth, Indiana, Forente stater, 46563
- Michiana Hematology Oncology PC-Plymouth
-
Richmond, Indiana, Forente stater, 47374
- Reid Hospital and Health Care Services
-
South Bend, Indiana, Forente stater, 46601
- Memorial Hospital of South Bend
-
South Bend, Indiana, Forente stater, 46601
- Michiana Hematology Oncology PC-South Bend
-
South Bend, Indiana, Forente stater, 46617
- South Bend Clinic
-
South Bend, Indiana, Forente stater, 46601
- Northern Indiana Cancer Research Consortium
-
Westville, Indiana, Forente stater, 46391
- Michiana Hematology Oncology-PC Westville
-
-
Iowa
-
Ames, Iowa, Forente stater, 50010
- McFarland Clinic
-
Bettendorf, Iowa, Forente stater, 52722
- Constantinou, Costas L MD (UIA Investigator)
-
Bettendorf, Iowa, Forente stater, 52722
- Hematology Oncology Associates-Quad Cities
-
Cedar Rapids, Iowa, Forente stater, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Forente stater, 52403
- Oncology Associates at Mercy Medical Center
-
Cedar Rapids, Iowa, Forente stater, 52402
- Saint Luke's Hospital
-
Cedar Rapids, Iowa, Forente stater, 52403
- Cedar Rapids Oncology Association
-
Cedar Rapids, Iowa, Forente stater, 52402
- Helen G Nassif Community Cancer Center
-
Clive, Iowa, Forente stater, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Forente stater, 50325
- Medical Oncology and Hematology Associates-West Des Moines
-
Davenport, Iowa, Forente stater, 52803
- Genesis Medical Center - East Campus
-
Des Moines, Iowa, Forente stater, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Forente stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forente stater, 50309
- Medical Oncology and Hematology Associates-Des Moines
-
Des Moines, Iowa, Forente stater, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Forente stater, 50309
- Iowa Oncology Research Association CCOP
-
Des Moines, Iowa, Forente stater, 50314
- Medical Oncology and Hematology Associates
-
Iowa City, Iowa, Forente stater, 52242
- University of Iowa Hospitals and Clinics
-
Mason City, Iowa, Forente stater, 50401
- Mercy Medical Center - North Iowa
-
Ottumwa, Iowa, Forente stater, 52501
- Ottumwa Regional Health Center
-
Sioux City, Iowa, Forente stater, 51104
- Saint Luke's Regional Medical Center
-
Sioux City, Iowa, Forente stater, 51101
- Siouxland Hematology Oncology Associates
-
Sioux City, Iowa, Forente stater, 51104
- Mercy Medical Center-Sioux City
-
Waterloo, Iowa, Forente stater, 50702
- Covenant Medical Center
-
West Des Moines, Iowa, Forente stater, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Forente stater, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, Forente stater, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, Forente stater, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Forente stater, 67042
- Cancer Center of Kansas - El Dorado
-
Emporia, Kansas, Forente stater, 66801
- Newman Regional Health
-
Fort Scott, Kansas, Forente stater, 66701
- Cancer Center of Kansas - Fort Scott
-
Great Bend, Kansas, Forente stater, 67530
- Saint Rose Ambulatory and Surgery Center
-
Hays, Kansas, Forente stater, 67601
- Hays Medical Center
-
Hutchinson, Kansas, Forente stater, 65702
- Promise Regional Medical Center-Hutchinson
-
Independence, Kansas, Forente stater, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, Forente stater, 66160
- University of Kansas Medical Center
-
Kansas City, Kansas, Forente stater, 66112
- Kansas City Cancer Center-West
-
Kingman, Kansas, Forente stater, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Forente stater, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, Forente stater, 67901
- Cancer Center of Kansas-Liberal
-
McPherson, Kansas, Forente stater, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, Forente stater, 67114
- Cancer Center of Kansas - Newton
-
Overland Park, Kansas, Forente stater, 66209
- Menorah Medical Center
-
Overland Park, Kansas, Forente stater, 66213
- Saint Luke's South Hospital
-
Overland Park, Kansas, Forente stater, 66210
- Kansas City Cancer Centers-Southwest
-
Parsons, Kansas, Forente stater, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, Forente stater, 66762
- Via Christi Hospital-Pittsburg
-
Prairie Village, Kansas, Forente stater, 66208
- Kansas City CCOP
-
Pratt, Kansas, Forente stater, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Forente stater, 67401
- Salina Regional Health Center
-
Salina, Kansas, Forente stater, 67401
- Cancer Center of Kansas - Salina
-
Shawnee Mission, Kansas, Forente stater, 66204
- Kansas City Cancer Center-Shawnee Mission
-
Topeka, Kansas, Forente stater, 66606
- Saint Francis Hospital and Medical Center - Topeka
-
Topeka, Kansas, Forente stater, 66604
- Stormont-Vail Regional Health Center
-
Wellington, Kansas, Forente stater, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, Forente stater, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Forente stater, 67208
- Associates In Womens Health
-
Wichita, Kansas, Forente stater, 67214
- Cancer Center of Kansas - Main Office
-
Wichita, Kansas, Forente stater, 67214
- Via Christi Regional Medical Center
-
Wichita, Kansas, Forente stater, 67214
- Wichita CCOP
-
Winfield, Kansas, Forente stater, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Corbin, Kentucky, Forente stater, 40701
- Baptist Regional Medical Center
-
Lexington, Kentucky, Forente stater, 40536
- University Of Kentucky
-
Lexington, Kentucky, Forente stater, 40503
- Baptist Health Lexington
-
Louisville, Kentucky, Forente stater, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Forente stater, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, Forente stater, 40202
- Norton Health Care Pavilion - Downtown
-
-
Louisiana
-
Alexandria, Louisiana, Forente stater, 71301
- Christus Saint Frances Cabrini Hospital
-
Baton Rouge, Louisiana, Forente stater, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Forente stater, 70809
- Hematology/Oncology Clinic LLP
-
Baton Rouge, Louisiana, Forente stater, 70809
- Ochsner Clinic Foundation-Baton Rouge
-
Covington, Louisiana, Forente stater, 70433
- Ochsner North Shore Medical Center
-
New Orleans, Louisiana, Forente stater, 70112
- Tulane University Health Sciences Center
-
New Orleans, Louisiana, Forente stater, 70112
- Louisiana State University Health Science Center
-
New Orleans, Louisiana, Forente stater, 70112
- Interim LSU Public Hospital
-
New Orleans, Louisiana, Forente stater, 70115
- Ochsner Baptist Medical Center
-
New Orleans, Louisiana, Forente stater, 70121
- Ochsner Clinic CCOP
-
Shreveport, Louisiana, Forente stater, 71101
- Christus Schumpert Saint Mary's Place
-
-
Maine
-
Augusta, Maine, Forente stater, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, Forente stater, 04401
- Eastern Maine Medical Center
-
Portland, Maine, Forente stater, 04101
- Mercy Hospital
-
Rockport, Maine, Forente stater, 04856
- Penobscot Bay Medical Center
-
Scarborough, Maine, Forente stater, 04074
- Maine Center for Cancer Medicine and Blood Disorders-Scarborough
-
-
Maryland
-
Annapolis, Maryland, Forente stater, 21401
- Anne Arundel Medical Center
-
Baltimore, Maryland, Forente stater, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, Forente stater, 21229
- Saint Agnes Hospital
-
Baltimore, Maryland, Forente stater, 21287-8936
- Johns Hopkins University
-
Baltimore, Maryland, Forente stater, 21244
- Kaiser Permanente-Woodlawn Medical Center
-
Baltimore, Maryland, Forente stater, 21237
- Franklin Square Hospital Center
-
Baltimore, Maryland, Forente stater, 21218
- The Union Memorial Hospital
-
Columbia, Maryland, Forente stater, 21044
- Maryland Oncology Hematology PA-Columbia
-
Easton, Maryland, Forente stater, 21601
- The Memorial Hospital at Easton
-
Elkton, Maryland, Forente stater, 21921
- Union Hospital of Cecil County
-
Frederick, Maryland, Forente stater, 21701
- Frederick Memorial Hospital
-
Gaithersburg, Maryland, Forente stater, 20879
- Kaiser Permanente-Gaithersburg Medical Center
-
Largo, Maryland, Forente stater, 20774
- Kaiser Permanente - Largo Medical Center
-
Salisbury, Maryland, Forente stater, 21801
- Peninsula Regional Medical Center
-
Silver Spring, Maryland, Forente stater, 20910
- Holy Cross Hospital
-
-
Massachusetts
-
Beverly, Massachusetts, Forente stater, 01915
- Beverly Hospital
-
Boston, Massachusetts, Forente stater, 02111
- Tufts Medical Center
-
Boston, Massachusetts, Forente stater, 02118
- Boston Medical Center
-
Burlington, Massachusetts, Forente stater, 01805
- Lahey Hospital and Medical Center
-
Fall River, Massachusetts, Forente stater, 02721
- Saint Anne's Hospital
-
Gloucester, Massachusetts, Forente stater, 01930
- Addison Gilbert Hospital
-
Lowell, Massachusetts, Forente stater, 01854
- Lowell General Hospital
-
Methuen, Massachusetts, Forente stater, 01844
- Holy Family Hospital
-
Newton, Massachusetts, Forente stater, 02462
- Newton-Wellesley Hospital
-
Pittsfield, Massachusetts, Forente stater, 01201
- Berkshire Hematology Oncology PC
-
Plymouth, Massachusetts, Forente stater, 02360
- Jordan Hospital
-
Springfield, Massachusetts, Forente stater, 01199
- Baystate Medical Center
-
-
Michigan
-
Adrian, Michigan, Forente stater, 49221
- Bixby Medical Center
-
Adrian, Michigan, Forente stater, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, Forente stater, 48109
- University of Michigan
-
Ann Arbor, Michigan, Forente stater, 48106-0995
- Saint Joseph Mercy Hospital
-
Ann Arbor, Michigan, Forente stater, 48106
- Michigan Cancer Research Consortium Community Clinical Oncology Program
-
Battle Creek, Michigan, Forente stater, 49017
- Bronson Battle Creek
-
Bay City, Michigan, Forente stater, 48708
- Bay Regional Medical Center
-
Big Rapids, Michigan, Forente stater, 49307
- Mecosta County Medical Center
-
Clarkston, Michigan, Forente stater, 48346
- Great Lakes Cancer Institute
-
Dearborn, Michigan, Forente stater, 48124
- Oakwood Hospital
-
Detroit, Michigan, Forente stater, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Forente stater, 48236
- Saint John Hospital and Medical Center
-
Detroit, Michigan, Forente stater, 48202
- Wayne State University
-
Escanaba, Michigan, Forente stater, 49431
- Green Bay Oncology - Escanaba
-
Farmington Hills, Michigan, Forente stater, 48334
- Weisberg Cancer Treatment Center
-
Flint, Michigan, Forente stater, 48502
- Hurley Medical Center
-
Flint, Michigan, Forente stater, 48532
- Genesys Regional Medical Center-West Flint Campus
-
Flint, Michigan, Forente stater, 48532
- Singh and Arora Hematology Oncology PC
-
Flint, Michigan, Forente stater, 48503
- Genesys Hurley Cancer Institute
-
Flint, Michigan, Forente stater, 48532
- McLaren Regional Cancer Center
-
Grand Blanc, Michigan, Forente stater, 48439
- Genesys Regional Medical Center
-
Grand Rapids, Michigan, Forente stater, 49503
- Spectrum Health at Butterworth Campus
-
Grand Rapids, Michigan, Forente stater, 49503
- Grand Rapids Clinical Oncology Program
-
Grand Rapids, Michigan, Forente stater, 49503
- Saint Mary's Health Care
-
Iron Mountain, Michigan, Forente stater, 49801
- Green Bay Oncology - Iron Mountain
-
Jackson, Michigan, Forente stater, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Forente stater, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Forente stater, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Forente stater, 49001
- Borgess Medical Center
-
Lansing, Michigan, Forente stater, 48912
- Sparrow Hospital
-
Lansing, Michigan, Forente stater, 48910
- Michigan State University - Breslin Cancer Center
-
Lapeer, Michigan, Forente stater, 48446
- Great Lakes Cancer Institute-Lapeer Campus
-
Livonia, Michigan, Forente stater, 48154
- Saint Mary Mercy Hospital
-
Marquette, Michigan, Forente stater, 49855
- Marquette General Hospital
-
Monroe, Michigan, Forente stater, 48162
- Mercy Memorial Hospital
-
Monroe, Michigan, Forente stater, 48162
- Community Cancer Center of Monroe
-
Mount Clemens, Michigan, Forente stater, 48043
- Mount Clemens Regional Medical Center
-
Muskegon, Michigan, Forente stater, 49444
- Mercy Health Partners-Mercy Campus
-
Owosso, Michigan, Forente stater, 48867
- Memorial Healthcare Center
-
Petoskey, Michigan, Forente stater, 49770
- Northern Michigan Regional Hospital
-
Pontiac, Michigan, Forente stater, 48341-2985
- Saint Joseph Mercy Oakland
-
Port Huron, Michigan, Forente stater, 48060
- Saint Joseph Mercy Port Huron
-
Reed City, Michigan, Forente stater, 49677
- Spectrum Health Reed City Hospital
-
Royal Oak, Michigan, Forente stater, 48073
- William Beaumont Hospital
-
Saginaw, Michigan, Forente stater, 48601
- Saint Mary's of Michigan
-
Saint Joseph, Michigan, Forente stater, 49085
- Marie Yeager Cancer Center
-
Saint Joseph, Michigan, Forente stater, 49085
- Lakeland Hospital
-
Southfield, Michigan, Forente stater, 48075
- Providence Hospital
-
Traverse City, Michigan, Forente stater, 49684
- Munson Medical Center
-
Troy, Michigan, Forente stater, 48098
- William Beaumont Hospital - Troy
-
Warren, Michigan, Forente stater, 48093
- Saint John Macomb-Oakland Hospital
-
-
Minnesota
-
Bemidji, Minnesota, Forente stater, 56601
- Sanford Clinic North-Bemidgi
-
Brainerd, Minnesota, Forente stater, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Forente stater, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Forente stater, 55433
- Mercy Hospital
-
Duluth, Minnesota, Forente stater, 55805
- Saint Luke's Hospital of Duluth
-
Duluth, Minnesota, Forente stater, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Forente stater, 55805
- Miller-Dwan Hospital
-
Duluth, Minnesota, Forente stater, 55805
- Essentia Health Duluth Clinic CCOP
-
Edina, Minnesota, Forente stater, 55435
- Fairview-Southdale Hospital
-
Fergus Falls, Minnesota, Forente stater, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, Forente stater, 55432
- Unity Hospital
-
Hutchinson, Minnesota, Forente stater, 55350
- Hutchinson Area Health Care
-
Mankato, Minnesota, Forente stater, 56002
- Mayo Clinic Health System in Mankato
-
Maplewood, Minnesota, Forente stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forente stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forente stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forente stater, 55407
- Abbott-Northwestern Hospital
-
New Ulm, Minnesota, Forente stater, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, Forente stater, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Forente stater, 55905
- Mayo Clinic
-
Saint Cloud, Minnesota, Forente stater, 56303
- Saint Cloud Hospital
-
Saint Cloud, Minnesota, Forente stater, 56303
- CentraCare Clinic
-
Saint Louis Park, Minnesota, Forente stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, Forente stater, 55416
- Metro-Minnesota CCOP
-
Saint Paul, Minnesota, Forente stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forente stater, 55102
- United Hospital
-
Shakopee, Minnesota, Forente stater, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Forente stater, 55082
- Lakeview Hospital
-
Waconia, Minnesota, Forente stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forente stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forente stater, 55125
- Minnesota Oncology and Hematology PA-Woodbury
-
-
Mississippi
-
Gulfport, Mississippi, Forente stater, 39502
- Gulfport Memorial Hospital
-
Hattiesburg, Mississippi, Forente stater, 39404
- Forest General Hospital
-
Jackson, Mississippi, Forente stater, 39216
- University of Mississippi Medical Center
-
Pascagoula, Mississippi, Forente stater, 39581
- Singing River Hospital
-
-
Missouri
-
Bolivar, Missouri, Forente stater, 65613
- Central Care Cancer Center-Carrie J Babb Cancer Center
-
Branson, Missouri, Forente stater, 65616
- CoxHealth Cancer Center
-
Cape Girardeau, Missouri, Forente stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forente stater, 63703
- Southeast Cancer Center
-
Chesterfield, Missouri, Forente stater, 63017
- Saint Luke's Hospital
-
Columbia, Missouri, Forente stater, 65203
- University of Missouri - Ellis Fischel
-
Jefferson City, Missouri, Forente stater, 65109
- Capital Region Medical Center-Goldschmidt Cancer Center
-
Joplin, Missouri, Forente stater, 64804
- Freeman Health System
-
Joplin, Missouri, Forente stater, 64804
- Saint John's Regional Medical Center
-
Kansas City, Missouri, Forente stater, 64116
- North Kansas City Hospital
-
Kansas City, Missouri, Forente stater, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, Forente stater, 64132
- Research Medical Center
-
Kansas City, Missouri, Forente stater, 64108
- Truman Medical Center
-
Kansas City, Missouri, Forente stater, 64118
- Heartland Hematology and Oncology Associates Incorporated
-
Kansas City, Missouri, Forente stater, 64111
- Saint Luke's Cancer Institute
-
Kansas City, Missouri, Forente stater, 64131
- Kansas City Cancer Center - South
-
Kansas City, Missouri, Forente stater, 64154
- Kansas City Cancer Centers - North
-
Lee's Summit, Missouri, Forente stater, 64086
- Saint Luke's East - Lee's Summit
-
Lee's Summit, Missouri, Forente stater, 64064
- Kansas City Cancer Center-Lee's Summit
-
Liberty, Missouri, Forente stater, 64068
- Liberty Radiation Oncology Clinic
-
Rolla, Missouri, Forente stater, 65401
- Phelps County Regional Medical Center
-
Rolla, Missouri, Forente stater, 65401
- Saint John's Clinic-Rolla-Cancer and Hematology
-
Saint Joseph, Missouri, Forente stater, 64506
- Heartland Regional Medical Center
-
Saint Joseph, Missouri, Forente stater, 64507
- Saint Joseph Oncology Inc
-
Saint Louis, Missouri, Forente stater, 63110
- Washington University School of Medicine
-
Saint Louis, Missouri, Forente stater, 63110
- Saint Louis University Hospital
-
Saint Louis, Missouri, Forente stater, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, Forente stater, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Saint Louis, Missouri, Forente stater, 63141
- Saint John's Mercy Medical Center
-
Saint Louis, Missouri, Forente stater, 63141
- Saint Louis-Cape Girardeau CCOP
-
Saint Louis, Missouri, Forente stater, 63141
- Comprehensive Cancer Care PC
-
Springfield, Missouri, Forente stater, 65802
- Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield
-
Springfield, Missouri, Forente stater, 65807
- Cox Medical Center
-
Springfield, Missouri, Forente stater, 65804
- Saint John's Hospital
-
-
Montana
-
Billings, Montana, Forente stater, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Forente stater, 59101
- Montana Cancer Consortium CCOP
-
Billings, Montana, Forente stater, 59102
- Hematology-Oncology Centers of the Northern Rockies PC
-
Billings, Montana, Forente stater, 59107-7000
- Billings Clinic
-
Bozeman, Montana, Forente stater, 59715
- Bozeman Deaconess Hospital
-
Bozeman, Montana, Forente stater, 59715
- Bozeman Deaconess Cancer Center
-
Butte, Montana, Forente stater, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Forente stater, 59405
- Great Falls Clinic
-
Great Falls, Montana, Forente stater, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Great Falls, Montana, Forente stater, 59405
- Big Sky Oncology
-
Havre, Montana, Forente stater, 59501
- Northern Montana Hospital
-
Helena, Montana, Forente stater, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Forente stater, 59901
- Kalispell Regional Medical Center
-
Kalispell, Montana, Forente stater, 59901
- Glacier Oncology PLLC
-
Kalispell, Montana, Forente stater, 59901
- Kalispell Medical Oncology
-
Missoula, Montana, Forente stater, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Forente stater, 59802
- Montana Cancer Specialists
-
-
Nebraska
-
Kearney, Nebraska, Forente stater, 68847
- Good Samaritan Hospital
-
Lincoln, Nebraska, Forente stater, 68510
- Lincoln Medical Education Foundation Cancer Resource Center
-
Omaha, Nebraska, Forente stater, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, Forente stater, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Forente stater, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Forente stater, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Forente stater, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, Forente stater, 68106
- Missouri Valley Cancer Consortium CCOP
-
-
Nevada
-
Las Vegas, Nevada, Forente stater, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Forente stater, 89106
- Nevada Cancer Research Foundation CCOP
-
-
New Hampshire
-
Concord, New Hampshire, Forente stater, 03301
- New Hampshire Oncology-Hematology PA
-
Hooksett, New Hampshire, Forente stater, 03106
- New Hampshire Oncology Hematology Associates
-
Laconia, New Hampshire, Forente stater, 03246
- LRGHealthcare-Lakes Region General Hospital
-
Nashua, New Hampshire, Forente stater, 03060
- Saint Joseph Hospital
-
Portsmouth, New Hampshire, Forente stater, 03802
- Portsmouth Regional Hospital
-
-
New Jersey
-
Camden, New Jersey, Forente stater, 08103
- Cooper Hospital University Medical Center
-
Englewood, New Jersey, Forente stater, 07631
- Englewood Hospital and Medical Center
-
Flemington, New Jersey, Forente stater, 08822
- Hunterdon Medical Center
-
Hamilton, New Jersey, Forente stater, 08690
- Cancer Institute of New Jersey at Hamilton
-
Neptune, New Jersey, Forente stater, 07753
- Jersey Shore Medical Center
-
New Brunswick, New Jersey, Forente stater, 08903
- Cancer Institute Of New Jersey
-
Newark, New Jersey, Forente stater, 07112
- Newark Beth Israel Medical Center
-
Pennington, New Jersey, Forente stater, 08534
- Capital Health Medical Center-Hopewell
-
Ridgewood, New Jersey, Forente stater, 07450
- Valley Hospital
-
Somerville, New Jersey, Forente stater, 08876
- Somerset Medical Center
-
Sparta, New Jersey, Forente stater, 07871
- Sparta Cancer Treatment Center
-
Toms River, New Jersey, Forente stater, 08755
- Community Medical Center
-
Vineland, New Jersey, Forente stater, 08360
- South Jersey Healthcare
-
-
New Mexico
-
Albuquerque, New Mexico, Forente stater, 87106
- University of New Mexico
-
Albuquerque, New Mexico, Forente stater, 87109
- New Mexico Oncology Hematology Consultants
-
Albuquerque, New Mexico, Forente stater, 87106
- Hematology Oncology Associates
-
Albuquerque, New Mexico, Forente stater, 87110
- Presbyterian Kaseman Hospital
-
Las Cruces, New Mexico, Forente stater, 88011
- Memorial Medical Center - Las Cruces
-
Santa Fe, New Mexico, Forente stater, 87505
- New Mexico Cancer Care Associates
-
-
New York
-
Albany, New York, Forente stater, 12208
- New York Oncology Hematology PC -Albany Medical Center
-
Albany, New York, Forente stater, 12206
- New York Oncology Hematology PC - Albany
-
Amsterdam, New York, Forente stater, 12010
- New York Oncology Hematology PC - Amsterdam
-
Bronx, New York, Forente stater, 10461
- Albert Einstein College of Medicine
-
Bronx, New York, Forente stater, 10467-2490
- Montefiore Medical Center
-
Brooklyn, New York, Forente stater, 11219
- Maimonides Medical Center
-
Brooklyn, New York, Forente stater, 11203
- Kings County Hospital
-
Brooklyn, New York, Forente stater, 11203
- State University of New York Downstate Medical Center
-
Buffalo, New York, Forente stater, 14263
- Roswell Park Cancer Institute
-
Cooperstown, New York, Forente stater, 13326
- Mary Imogene Bassett Hospital
-
East Syracuse, New York, Forente stater, 13057
- Hematology Oncology Associates of Central New York PC
-
Hudson, New York, Forente stater, 12534
- New York Oncology Hematology PC-Hudson
-
Johnson City, New York, Forente stater, 13790
- Broome Oncology LLC
-
Lake Success, New York, Forente stater, 11042
- Monter Cancer Center
-
Latham, New York, Forente stater, 12110
- New York Oncology Hematology PC - Latham
-
Manhasset, New York, Forente stater, 11030
- North Shore University Hospital
-
Manhasset, New York, Forente stater, 11030
- North Shore-LIJ Health System CCOP
-
Mineola, New York, Forente stater, 11501
- Winthrop University Hospital
-
New Hyde Park, New York, Forente stater, 11040
- Long Island Jewish Medical Center
-
New York, New York, Forente stater, 10032
- Columbia University Medical Center
-
New York, New York, Forente stater, 10029
- Mount Sinai Medical Center
-
Poughkeepsie, New York, Forente stater, 12601
- Vassar Brothers Medical Center
-
Poughkeepsie, New York, Forente stater, 12601
- Saint Francis
-
Rochester, New York, Forente stater, 14642
- University of Rochester
-
Staten Island, New York, Forente stater, 10305
- Staten Island University Hospital
-
Stony Brook, New York, Forente stater, 11794
- Stony Brook University Medical Center
-
-
North Carolina
-
Asheboro, North Carolina, Forente stater, 27203
- Randolph Hospital
-
Asheville, North Carolina, Forente stater, 28801
- Mission Hospitals
-
Asheville, North Carolina, Forente stater, 28816
- Hope Women's Cancer Centers-Asheville
-
Burlington, North Carolina, Forente stater, 27216
- Alamance Regional Medical Center
-
Cary, North Carolina, Forente stater, 27518
- Waverly Hematology Oncology
-
Charlotte, North Carolina, Forente stater, 28203
- Carolinas Medical Center
-
Charlotte, North Carolina, Forente stater, 28204
- Presbyterian Hospital
-
Concord, North Carolina, Forente stater, 28025
- Carolinas Medical Center - Northeast
-
Gastonia, North Carolina, Forente stater, 28054
- Gaston Memorial Hospital
-
Goldsboro, North Carolina, Forente stater, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, Forente stater, 27403
- Cone Health Cancer Center
-
Hendersonville, North Carolina, Forente stater, 28791
- Margaret R Pardee Memorial Hospital
-
Hendersonville, North Carolina, Forente stater, 28792
- Park Ridge Hospital Breast Health Center
-
Kinston, North Carolina, Forente stater, 28501
- Kinston Medical Specialists PA
-
Monroe, North Carolina, Forente stater, 28112
- Carolinas Medical Center-Union
-
Pinehurst, North Carolina, Forente stater, 28374
- FirstHealth of the Carolinas-Moore Regional Hosiptal
-
Raleigh, North Carolina, Forente stater, 27607
- Rex Cancer Center
-
Raleigh, North Carolina, Forente stater, 27614
- Rex Cancer Center of Wakefield
-
Reidsville, North Carolina, Forente stater, 27320
- Annie Penn Memorial Hospital
-
Rutherfordton, North Carolina, Forente stater, 28139
- Rutherford Hospital
-
Shelby, North Carolina, Forente stater, 28150
- Cleveland Regional Medical Center
-
Statesville, North Carolina, Forente stater, 28677
- Iredell Memorial Hospital
-
Washington, North Carolina, Forente stater, 27889
- Marion L Shepard Cancer Center
-
Wilmington, North Carolina, Forente stater, 28401
- New Hanover Regional Medical Center
-
Winston-Salem, North Carolina, Forente stater, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, Forente stater, 27103
- Forsyth Memorial Hospital
-
-
North Dakota
-
Bismarck, North Dakota, Forente stater, 58501
- Sanford Bismarck Medical Center
-
Bismarck, North Dakota, Forente stater, 58501
- Bismarck Cancer Center
-
Bismarck, North Dakota, Forente stater, 58501
- Mid Dakota Clinic
-
Bismarck, North Dakota, Forente stater, 58501
- Saint Alexius Medical Center
-
Fargo, North Dakota, Forente stater, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Forente stater, 58122
- Sanford Clinic North-Fargo
-
Fargo, North Dakota, Forente stater, 58122
- Sanford Medical Center-Fargo
-
Fargo, North Dakota, Forente stater, 58122
- Roger Maris Cancer Center
-
Grand Forks, North Dakota, Forente stater, 58201
- Altru Cancer Center
-
-
Ohio
-
Akron, Ohio, Forente stater, 44307
- Akron General Medical Center
-
Akron, Ohio, Forente stater, 44304
- Summa Akron City Hospital
-
Barberton, Ohio, Forente stater, 44203
- Summa Barberton Hospital
-
Beachwood, Ohio, Forente stater, 44122
- Cleveland Clinic Cancer Center Beachwood
-
Belpre, Ohio, Forente stater, 45714
- Strecker Cancer Center-Belpre
-
Bowling Green, Ohio, Forente stater, 43402
- Toledo Clinic Cancer Centers-Bowling Green
-
Canton, Ohio, Forente stater, 44710
- Aultman Health Foundation
-
Canton, Ohio, Forente stater, 44708
- Mercy Medical Center
-
Chillicothe, Ohio, Forente stater, 45601
- Adena Regional Medical Center
-
Cleveland, Ohio, Forente stater, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Forente stater, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, Forente stater, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Columbus, Ohio, Forente stater, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Forente stater, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Forente stater, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Forente stater, 43228
- Doctors Hospital
-
Columbus, Ohio, Forente stater, 43215
- Grant Medical Center
-
Columbus, Ohio, Forente stater, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, Forente stater, 43215
- Columbus CCOP
-
Dayton, Ohio, Forente stater, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Forente stater, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Forente stater, 45415
- Samaritan North Health Center
-
Dayton, Ohio, Forente stater, 45405
- Grandview Hospital
-
Dayton, Ohio, Forente stater, 45420
- Dayton CCOP
-
Delaware, Ohio, Forente stater, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Forente stater, 43015
- Grady Memorial Hospital
-
Elyria, Ohio, Forente stater, 44035
- Hematology Oncology Center Incorporated
-
Elyria, Ohio, Forente stater, 44035
- Community Health Partners Regional Medical Center
-
Findlay, Ohio, Forente stater, 45840
- Blanchard Valley Hospital
-
Franklin, Ohio, Forente stater, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Greenville, Ohio, Forente stater, 45331
- Wayne Hospital
-
Independence, Ohio, Forente stater, 44131
- Cleveland Clinic Cancer Center Independence
-
Kettering, Ohio, Forente stater, 45429
- Kettering Medical Center
-
Lancaster, Ohio, Forente stater, 43130
- Fairfield Medical Center
-
Lima, Ohio, Forente stater, 45801
- Saint Rita's Medical Center
-
Lima, Ohio, Forente stater, 45804
- Lima Memorial Hospital
-
Mansfield, Ohio, Forente stater, 44903
- Mansfield General Hospital-MedCentral Health System
-
Marietta, Ohio, Forente stater, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, Forente stater, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Maumee, Ohio, Forente stater, 43537-1839
- Toledo Clinic Cancer Centers-Maumee
-
Mayfield Heights, Ohio, Forente stater, 44124
- Hillcrest Hospital Cancer Center
-
Mount Vernon, Ohio, Forente stater, 43050
- Knox Community Hospital
-
Newark, Ohio, Forente stater, 43055
- Licking Memorial Hospital
-
Oregon, Ohio, Forente stater, 43616
- Saint Charles Hospital
-
Oregon, Ohio, Forente stater, 43616
- Toledo Clinic Cancer Centers-Oregon
-
Parma, Ohio, Forente stater, 44129
- Parma Community General Hospital
-
Portsmouth, Ohio, Forente stater, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, Forente stater, 44870
- North Coast Cancer Care
-
Springfield, Ohio, Forente stater, 45505
- Springfield Regional Medical Center
-
Steubenville, Ohio, Forente stater, 43952
- Trinity's Tony Teramana Cancer Center
-
Strongsville, Ohio, Forente stater, 44136
- Cleveland Clinic Cancer Center-Strongsville
-
Sylvania, Ohio, Forente stater, 43560
- Flower Hospital
-
Tiffin, Ohio, Forente stater, 44883
- Mercy Hospital of Tiffin
-
Toledo, Ohio, Forente stater, 43608
- Saint Vincent Mercy Medical Center
-
Toledo, Ohio, Forente stater, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Forente stater, 43614
- University of Toledo
-
Toledo, Ohio, Forente stater, 43617
- Toledo Community Hospital Oncology Program CCOP
-
Toledo, Ohio, Forente stater, 43606
- The Toledo Hospital/Toledo Children's Hospital
-
Toledo, Ohio, Forente stater, 43623
- Mercy Cancer Center at Saint Anne Mercy Hospital
-
Troy, Ohio, Forente stater, 45373
- Upper Valley Medical Center
-
Wauseon, Ohio, Forente stater, 43567
- Fulton County Health Center
-
Westerville, Ohio, Forente stater, 43081
- Saint Ann's Hospital
-
Wooster, Ohio, Forente stater, 44691
- Cleveland Clinic Wooster Specialty Center
-
Wright-Patterson Air Force Base, Ohio, Forente stater, 45433-5529
- Wright-Patterson Medical Center
-
Xenia, Ohio, Forente stater, 45385
- Greene Memorial Hospital
-
Zanesville, Ohio, Forente stater, 43701
- Genesis HealthCare System
-
-
Oklahoma
-
Lawton, Oklahoma, Forente stater, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Norman, Oklahoma, Forente stater, 73071
- Cancer Care Associates-Norman
-
Oklahoma City, Oklahoma, Forente stater, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Forente stater, 73120
- Cancer Care Associates-Mercy
-
Tulsa, Oklahoma, Forente stater, 74136
- Natalie W Bryant Cancer Center
-
-
Oregon
-
Clackamas, Oregon, Forente stater, 97015
- Clackamas Radiation Oncology Center
-
Grants Pass, Oregon, Forente stater, 97527
- Three Rivers Community Hospital
-
Gresham, Oregon, Forente stater, 97030
- Legacy Mount Hood Medical Center
-
Medford, Oregon, Forente stater, 97504
- Asante Health System
-
Medford, Oregon, Forente stater, 97504
- Providence Medford Medical Center
-
Medford, Oregon, Forente stater, 97504
- Rogue Valley Medical Center
-
Milwaukie, Oregon, Forente stater, 97222
- Providence Milwaukie Hospital
-
Newberg, Oregon, Forente stater, 97132
- Providence Newberg Medical Center
-
Oregon City, Oregon, Forente stater, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, Forente stater, 97210
- Legacy Good Samaritan Hospital and Medical Center
-
Portland, Oregon, Forente stater, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Forente stater, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Forente stater, 97227
- Kaiser Permanente
-
Portland, Oregon, Forente stater, 97225
- Columbia River Oncology Program
-
The Dalles, Oregon, Forente stater, 97058
- Mid-Columbia Medical Center
-
Tualatin, Oregon, Forente stater, 97062
- Legacy Meridian Park Hospital
-
-
Pennsylvania
-
Abington, Pennsylvania, Forente stater, 19001
- Abington Memorial Hospital
-
Allentown, Pennsylvania, Forente stater, 18105
- Lehigh Valley Hospital
-
Bethlehem, Pennsylvania, Forente stater, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bryn Mawr, Pennsylvania, Forente stater, 19010
- Bryn Mawr Hospital
-
Danville, Pennsylvania, Forente stater, 17822-2001
- Geisinger Medical Center
-
Doylestown, Pennsylvania, Forente stater, 18901
- Doylestown Hospital
-
Ephrata, Pennsylvania, Forente stater, 17522
- Ephrata Cancer Center
-
Erie, Pennsylvania, Forente stater, 16505
- The Regional Cancer Center
-
Gettysburg, Pennsylvania, Forente stater, 17325
- Adams Cancer Center
-
Hanover, Pennsylvania, Forente stater, 17331
- Cherry Tree Cancer Center
-
Harrisburg, Pennsylvania, Forente stater, 17110
- PinnacleHealth Fox Chase Regional Cancer Center at Polyclinic Hospital
-
Hazleton, Pennsylvania, Forente stater, 18201
- Geisinger Medical Center-Cancer Center Hazelton
-
Hershey, Pennsylvania, Forente stater, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Kingston, Pennsylvania, Forente stater, 18704
- Medical Oncology Associates
-
Kittanning, Pennsylvania, Forente stater, 16201
- Armstrong Center for Medicine and Health
-
Media, Pennsylvania, Forente stater, 19063
- Riddle Hospital
-
Monroeville, Pennsylvania, Forente stater, 15146
- Forbes Regional Hospital
-
Natrona Heights, Pennsylvania, Forente stater, 15065
- Alle-Kiski Medical Center
-
Paoli, Pennsylvania, Forente stater, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Forente stater, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Forente stater, 19107
- Pennsylvania Hospital
-
Phoenixville, Pennsylvania, Forente stater, 19460
- Phoenixville Hospital
-
Pittsburgh, Pennsylvania, Forente stater, 15232
- University of Pittsburgh
-
Pittsburgh, Pennsylvania, Forente stater, 15212
- Allegheny Cancer Center at Allegheny General Hospital
-
Pittsburgh, Pennsylvania, Forente stater, 15224-1791
- Western Pennsylvania Hospital
-
Pottstown, Pennsylvania, Forente stater, 19464
- Pottstown Memorial Medical Center
-
Reading, Pennsylvania, Forente stater, 19605
- Saint Joseph Medical Center
-
Sayre, Pennsylvania, Forente stater, 18840
- Guthrie Clinic-Robert Packer Hospital
-
Scranton, Pennsylvania, Forente stater, 18510
- Scranton Hematology Oncology
-
Scranton, Pennsylvania, Forente stater, 18501
- Mercy Hospital
-
Scranton, Pennsylvania, Forente stater, 18508
- Hematology and Oncology Associates of North East Pennsylvania
-
Sellersville, Pennsylvania, Forente stater, 18960
- Grand View Hospital
-
State College, Pennsylvania, Forente stater, 16801
- Geisinger Medical Group
-
Upland, Pennsylvania, Forente stater, 19013
- Associates In Hematology Oncology PC-Upland
-
West Chester, Pennsylvania, Forente stater, 19380
- Chester County Hospital
-
West Reading, Pennsylvania, Forente stater, 19612
- Reading Hospital and Medical Center
-
Wilkes-Barre, Pennsylvania, Forente stater, 18711
- Geisinger Wyoming Valley
-
Williamsport, Pennsylvania, Forente stater, 17701
- Susquehanna Cancer Center
-
Wynnewood, Pennsylvania, Forente stater, 19096
- Lankenau Hospital
-
Wynnewood, Pennsylvania, Forente stater, 19096
- Mainline Health CCOP
-
York, Pennsylvania, Forente stater, 17405
- York Hospital
-
-
Rhode Island
-
Providence, Rhode Island, Forente stater, 02903
- Rhode Island Hospital
-
Providence, Rhode Island, Forente stater, 02905
- Women and Infants Hospital
-
Providence, Rhode Island, Forente stater, 02906
- Miriam Hospital
-
Warwick, Rhode Island, Forente stater, 02886
- Kent County Hospital
-
-
South Carolina
-
Anderson, South Carolina, Forente stater, 29621
- AnMed Health Cancer Center
-
Anderson, South Carolina, Forente stater, 29621
- AnMed Health Hospital
-
Beaufort, South Carolina, Forente stater, 29902
- Beaufort Memorial Hospital
-
Charleston, South Carolina, Forente stater, 29425
- Medical University of South Carolina
-
Charleston, South Carolina, Forente stater, 29401
- Roper Hospital
-
Florence, South Carolina, Forente stater, 29506
- McLeod Regional Medical Center
-
Greenville, South Carolina, Forente stater, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, Forente stater, 29605
- Greenville Memorial Hospital
-
Greenville, South Carolina, Forente stater, 29605
- Cancer Centers of the Carolinas - Grove Commons
-
Greenville, South Carolina, Forente stater, 29605
- Cancer Centers of the Carolinas - Faris
-
Greenville, South Carolina, Forente stater, 29615
- Greenville CCOP
-
Greenwood, South Carolina, Forente stater, 29646
- Self Regional Healthcare
-
Greer, South Carolina, Forente stater, 29651
- Gibbs Cancer Center-Pelham
-
Greer, South Carolina, Forente stater, 29650
- Cancer Centers of the Carolinas-Greer Medical Oncology
-
Seneca, South Carolina, Forente stater, 29672
- Cancer Centers of the Carolinas - Seneca
-
Spartanburg, South Carolina, Forente stater, 29303
- Spartanburg Regional Medical Center
-
Spartanburg, South Carolina, Forente stater, 29303
- Upstate Carolina CCOP
-
Spartanburg, South Carolina, Forente stater, 29307
- Cancer Centers of the Carolinas - Spartanburg
-
-
South Dakota
-
Aberdeen, South Dakota, Forente stater, 57401
- Conklin Regional Cancer Center
-
Rapid City, South Dakota, Forente stater, 57701
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, Forente stater, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Forente stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forente stater, 57104
- Sanford Cancer Center-Oncology Clinic
-
-
Tennessee
-
Bristol, Tennessee, Forente stater, 37620
- Wellmont Bristol Regional Medical Center
-
Bristol, Tennessee, Forente stater, 37620
- Blue Ridge Medical Specialists PC
-
Chattanooga, Tennessee, Forente stater, 37403
- Erlanger Medical Center
-
Kingsport, Tennessee, Forente stater, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Knoxville, Tennessee, Forente stater, 37916
- Thompson Cancer Survival Center
-
Knoxville, Tennessee, Forente stater, 37920
- University of Tennessee - Knoxville
-
-
Texas
-
Abilene, Texas, Forente stater, 79606
- Texas Cancer Center
-
Amarillo, Texas, Forente stater, 79106
- Texas Oncology PA - Amarillo
-
Arlington, Texas, Forente stater, 76014
- Texas Oncology-Arlington South
-
Beaumont, Texas, Forente stater, 77702
- Texas Oncology PA Beaumont
-
Bedford, Texas, Forente stater, 76022
- Texas Oncology PA - Bedford
-
Bryan, Texas, Forente stater, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, Forente stater, 75230
- Texas Cancer Center - Medical City Dallas
-
Dallas, Texas, Forente stater, 75237
- Texas Oncology Methodist Charlton Cancer Center
-
Dallas, Texas, Forente stater, 75231
- Texas Health Presbyterian Hospital Dallas
-
Dallas, Texas, Forente stater, 75246
- Texas Oncology Pa
-
Denton, Texas, Forente stater, 76210
- Texas Oncology-Denton South
-
El Paso, Texas, Forente stater, 79915
- Texas Oncology-El Paso
-
Flower Mound, Texas, Forente stater, 75028
- Texas Oncology-Flower Mound
-
Fort Worth, Texas, Forente stater, 76104
- Texas Oncology Fort Worth at 12th Avenue
-
Garland, Texas, Forente stater, 75042
- Texas Oncology - Garland
-
Houston, Texas, Forente stater, 77030
- Baylor College of Medicine
-
Houston, Texas, Forente stater, 77030
- Methodist Hospital
-
Houston, Texas, Forente stater, 77024
- Memorial Hermann Memorial City Medical Center
-
Lewisville, Texas, Forente stater, 75067
- Texas Oncology - Lewisville
-
Lubbock, Texas, Forente stater, 79410
- Covenant Medical Center-Lakeside
-
Lubbock, Texas, Forente stater, 79430
- Texas Tech University Health Sciences Center
-
McAllen, Texas, Forente stater, 78503
- Texas Oncology-McAllen
-
Mesquite, Texas, Forente stater, 75150
- Texas Cancer Center - Mesquite
-
Midland, Texas, Forente stater, 79701
- Texas Oncology-Midland Allison Cancer Center
-
Paris, Texas, Forente stater, 75460
- Texas Oncology-Paris
-
Plano, Texas, Forente stater, 75075
- North Texas Regional Cancer Center
-
Round Rock, Texas, Forente stater, 78681
- Texas Oncology - Round Rock Cancer Center
-
Round Rock, Texas, Forente stater, 78665
- Scott and White Healthcare Round Rock
-
San Antonio, Texas, Forente stater, 78229-3900
- University of Texas Health Science Center at San Antonio
-
San Antonio, Texas, Forente stater, 78217
- Cancer Care Centers of South Texas- Northeast
-
Sherman, Texas, Forente stater, 75090
- Texas Cancer Center-Sherman
-
Temple, Texas, Forente stater, 76508
- Scott and White Memorial Hospital
-
The Woodlands, Texas, Forente stater, 77380
- US Oncology Research LLC-The Woodlands
-
Tyler, Texas, Forente stater, 75702
- Tyler Cancer Center
-
Waco, Texas, Forente stater, 76712
- Texas Oncology Pa
-
-
Utah
-
American Fork, Utah, Forente stater, 84003
- American Fork Hospital
-
Cedar City, Utah, Forente stater, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, Forente stater, 84321
- Logan Regional Hospital
-
Murray, Utah, Forente stater, 84157
- Intermountain Medical Center
-
Ogden, Utah, Forente stater, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Forente stater, 84604-3337
- Utah Valley Regional Medical Center
-
Saint George, Utah, Forente stater, 84770
- Dixie Medical Center Regional Cancer Center
-
Salt Lake City, Utah, Forente stater, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, Forente stater, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Forente stater, 84143
- LDS Hospital
-
-
Vermont
-
Berlin, Vermont, Forente stater, 05602
- Mountainview Medical
-
Burlington, Vermont, Forente stater, 05401
- University of Vermont
-
Rutland, Vermont, Forente stater, 05701
- Rutland Regional Medical Center
-
-
Virginia
-
Burke, Virginia, Forente stater, 22015
- Kaiser Permanente-Burke Medical Center
-
Charlottesville, Virginia, Forente stater, 22908
- University of Virginia
-
Fairfax, Virginia, Forente stater, 22033
- Kaiser Permanente - Fair Oaks Medical Center
-
Fairfax, Virginia, Forente stater, 22031
- Virginia Cancer Specialists-Fairfax
-
Fredericksburg, Virginia, Forente stater, 22401
- Fredericksburg Oncology Inc
-
Fredericksburg, Virginia, Forente stater, 22408
- Hematology Oncology Associates of Fredericksburg Inc
-
Gloucester, Virginia, Forente stater, 23061
- Peninsula Cancer Institute-Gloucester
-
Hampton, Virginia, Forente stater, 23666
- Virginia Oncology Associates-Hampton
-
McLean, Virginia, Forente stater, 22102
- Kaiser Permanente Tysons Corner Medical Center
-
Newport News, Virginia, Forente stater, 23601
- Peninsula Cancer Institute-Newport News
-
Norton, Virginia, Forente stater, 24273
- Southwest VA Regional Cancer Center
-
Richmond, Virginia, Forente stater, 23298
- Virginia Commonwealth University
-
Roanoke, Virginia, Forente stater, 24014
- Oncology and Hematology Associates of Southwest Virginia
-
South Hill, Virginia, Forente stater, 23970
- Community Memorial Health Center
-
Virginia Beach, Virginia, Forente stater, 23454
- Peninsula Cancer Institute-Cancer Specialists of Tidewater
-
Williamsburg, Virginia, Forente stater, 23185
- Peninsula Cancer Institute-Williamsburg
-
Winchester, Virginia, Forente stater, 22601
- Shenandoah Oncology Associates PC
-
-
Washington
-
Anacortes, Washington, Forente stater, 98221
- Cancer Care Center at Island Hospital
-
Auburn, Washington, Forente stater, 98002
- Auburn Regional Medical Center
-
Bellevue, Washington, Forente stater, 98004
- Overlake Hospital Medical Center
-
Bellingham, Washington, Forente stater, 98225
- PeaceHealth Saint Joseph Medical Center
-
Bremerton, Washington, Forente stater, 98310
- Harrison Medical Center
-
Bremerton, Washington, Forente stater, 98310
- Harrison Bremerton Hematology and Oncology
-
Burien, Washington, Forente stater, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, Forente stater, 98531
- Providence Centralia Hospital
-
Edmonds, Washington, Forente stater, 98026
- Swedish Medical Center-Edmonds
-
Edmonds, Washington, Forente stater, 98026
- Puget Sound Cancer Center
-
Everett, Washington, Forente stater, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Forente stater, 98003
- Saint Francis Hospital
-
Issaquah, Washington, Forente stater, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Forente stater, 99336
- Columbia Basin Hematology and Oncology PLLC
-
Kirkland, Washington, Forente stater, 98034
- Cascade Cancer Center
-
Mount Vernon, Washington, Forente stater, 98274
- Skagit Valley Hospital
-
Mount Vernon, Washington, Forente stater, 98274
- Skagit Valley Hospital Regional Cancer Care Center
-
Olympia, Washington, Forente stater, 98506-5166
- Providence - Saint Peter Hospital
-
Poulsbo, Washington, Forente stater, 98370
- Harrison Poulsbo Hematology and Oncology
-
Puyallup, Washington, Forente stater, 98372
- Good Samaritan Community Hospital
-
Seattle, Washington, Forente stater, 98195
- University of Washington Medical Center
-
Seattle, Washington, Forente stater, 98109
- Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
-
Seattle, Washington, Forente stater, 98104
- Harborview Medical Center
-
Seattle, Washington, Forente stater, 98104
- Minor and James Medical PLLC
-
Seattle, Washington, Forente stater, 98122-4307
- Swedish Medical Center-First Hill
-
Seattle, Washington, Forente stater, 98112
- Group Health Cooperative
-
Seattle, Washington, Forente stater, 98109
- Group Health
-
Sedro-Woolley, Washington, Forente stater, 98284
- United General Hospital
-
Sequim, Washington, Forente stater, 98384
- Olympic Medical Cancer Care Center
-
Spokane, Washington, Forente stater, 99218
- Evergreen Hematology and Oncology PS
-
Spokane, Washington, Forente stater, 99202
- Cancer Care Northwest - Spokane South
-
Spokane, Washington, Forente stater, 99220
- Rockwood Clinic
-
Spokane, Washington, Forente stater, 99218
- Cancer Care Northwest
-
Spokane, Washington, Forente stater, 99204
- Rockwood Cancer Treatment Center
-
Tacoma, Washington, Forente stater, 98405
- Saint Joseph Medical Center
-
Tacoma, Washington, Forente stater, 98405
- Allenmore Hospital
-
Tacoma, Washington, Forente stater, 98415
- MultiCare Health System
-
Tacoma, Washington, Forente stater, 98405
- Northwest CCOP
-
Tacoma, Washington, Forente stater, 98499
- Saint Clare Hospital
-
Vancouver, Washington, Forente stater, 98684
- Northwest Cancer Specialists
-
Vancouver, Washington, Forente stater, 98686
- Legacy Salmon Creek Hospital
-
Vancouver, Washington, Forente stater, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Forente stater, 99362
- Providence Saint Mary Regional Cancer Center
-
Wenatchee, Washington, Forente stater, 98801
- Wenatchee Valley Medical Center
-
Yakima, Washington, Forente stater, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
-
West Virginia
-
Charleston, West Virginia, Forente stater, 25304
- West Virginia University Charleston
-
Huntington, West Virginia, Forente stater, 25701
- Edwards Comprehensive Cancer Center
-
Martinsburg, West Virginia, Forente stater, 25401
- City Hospital
-
Morgantown, West Virginia, Forente stater, 26506
- West Virginia University
-
Princeton, West Virginia, Forente stater, 24740
- Princeton Community Hospital
-
Wheeling, West Virginia, Forente stater, 26003
- Wheeling Hospital
-
-
Wisconsin
-
Antigo, Wisconsin, Forente stater, 54409
- Langlade Hospital and Cancer Center
-
Appleton, Wisconsin, Forente stater, 54911-3496
- Fox Valley Hematology and Oncology
-
Chippewa Falls, Wisconsin, Forente stater, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, Forente stater, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Eau Claire, Wisconsin, Forente stater, 54702
- Midelfort Clinic-Clairemont Campus
-
Eau Claire, Wisconsin, Forente stater, 54703
- Mayo Clinic Health System Eau Claire Hospital - Luther Campus
-
Green Bay, Wisconsin, Forente stater, 54301
- Bellin Memorial Hospital
-
Green Bay, Wisconsin, Forente stater, 54301
- Saint Vincent Hospital
-
Green Bay, Wisconsin, Forente stater, 54303
- Green Bay Oncology Limited at Saint Mary's Hospital
-
Green Bay, Wisconsin, Forente stater, 54303
- Saint Mary's Hospital
-
Green Bay, Wisconsin, Forente stater, 54301-3526
- Green Bay Oncology at Saint Vincent Hospital
-
Green Bay, Wisconsin, Forente stater, 54311-6519
- Aurora BayCare Medical Center
-
Janesville, Wisconsin, Forente stater, 53547
- Mercy Health System
-
Johnson Creek, Wisconsin, Forente stater, 53038
- UW Cancer Center Johnson Creek
-
La Crosse, Wisconsin, Forente stater, 54601
- Mayo Clinic Health System-Franciscan Healthcare
-
La Crosse, Wisconsin, Forente stater, 54601
- Gundersen Lutheran
-
Madison, Wisconsin, Forente stater, 53792
- University of Wisconsin Hospital and Clinics
-
Madison, Wisconsin, Forente stater, 53717
- Dean Hematology and Oncology Clinic
-
Manitowoc, Wisconsin, Forente stater, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Forente stater, 54143
- Bay Area Medical Center
-
Marinette, Wisconsin, Forente stater, 54143
- Vince Lombardi Cancer Clinic-Marinette
-
Marshfield, Wisconsin, Forente stater, 54449
- Marshfield Clinic
-
Milwaukee, Wisconsin, Forente stater, 53226
- Froedtert and the Medical College of Wisconsin
-
Minocqua, Wisconsin, Forente stater, 54548
- Marshfield Clinic-Minocqua Center
-
Mukwonago, Wisconsin, Forente stater, 53149
- D N Greenwald Center
-
New Richmond, Wisconsin, Forente stater, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Forente stater, 53066-3896
- Oconomowoc Memorial Hospital-ProHealth Care Inc
-
Oconto Falls, Wisconsin, Forente stater, 54154
- Green Bay Oncology - Oconto Falls
-
Oshkosh, Wisconsin, Forente stater, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Rhinelander, Wisconsin, Forente stater, 54501
- Marshfield Clinic at James Beck Cancer Center
-
Rice Lake, Wisconsin, Forente stater, 54868
- Marshfield Clinic-Rice Lake Center
-
Sheboygan, Wisconsin, Forente stater, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, Forente stater, 53081
- Saint Nicholas Hospital
-
Stevens Point, Wisconsin, Forente stater, 54481
- Marshfield Clinic Cancer Care at Saint Michael's Hospital
-
Sturgeon Bay, Wisconsin, Forente stater, 54235
- Green Bay Oncology - Sturgeon Bay
-
Summit, Wisconsin, Forente stater, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Forente stater, 54241
- Vince Lombardi Cancer Clinic
-
Waukesha, Wisconsin, Forente stater, 53188
- Waukesha Memorial Hospital - ProHealth Care
-
Wausau, Wisconsin, Forente stater, 54401
- Aspirus Regional Cancer Center
-
Wausau, Wisconsin, Forente stater, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, Forente stater, 53226
- Aurora Cancer Care-Milwaukee West
-
Weston, Wisconsin, Forente stater, 54476
- Marshfield Clinic - Weston Center
-
Wisconsin Rapids, Wisconsin, Forente stater, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
Wisconsin Rapids, Wisconsin, Forente stater, 54494
- Riverview Hospital
-
-
Wyoming
-
Casper, Wyoming, Forente stater, 82609
- Rocky Mountain Oncology
-
Sheridan, Wyoming, Forente stater, 82801
- Welch Cancer Center
-
-
-
-
-
San Juan, Puerto Rico, 00936
- San Juan City Hospital
-
-
Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
18 år og eldre (Voksen, Eldre voksen)
Tar imot friske frivillige
Nei
Kjønn som er kvalifisert for studier
Hunn
Beskrivelse
Inklusjonskriterier:
- Pasienten må ha ytelsesstatus for Eastern Cooperative Oncology Group (ECOG) på 0 eller 1.
- Svulsten må være unilateralt invasivt adenokarsinom i brystet ved histologisk undersøkelse.
- Brystkreften må være Human Epidermal Growth Factor Receptor 2 (HER2)-negativ basert på gjeldende American Society of Clinical Oncology (ASCO)/CAP-retningslinjeanbefalinger for Human Epidermal Growth Factor Receptor 2-testing i brystkreft. Hvis resultatet av in situ hybridiseringstestingen (FISH, kromagen in situ hybridisering [CISH] eller annet) er tvetydig, er pasienten kvalifisert dersom det ikke er noen plan for å administrere HER2-målrettet behandling.
Alle følgende iscenesettelseskriterier må oppfylles i henhold til American Joint Committee on Cancer (AJCC) kriterier:
- Ved patologisk evaluering må primærtumor være pT1-3;
- Ved patologisk evaluering må ipsilaterale noder være pN0, pN1 (pN1mi, pN1a, pN1b, pN1c), pN2a, pN3a eller pN3b.
- Hvis pN0, må minst ett av følgende kriterier være oppfylt:
- ER negativ og PgR negativ; eller
- Patologisk tumorstørrelse større enn 2,0 cm; eller
- T1c (patologisk tumorstørrelse større enn 1,0 cm, men mindre enn eller lik 2,0 cm) og ER-positiv (PgR-status kan være positiv eller negativ) og enten grad 3 histologi eller Oncotype DX®-residivscore på større enn eller lik 25.
- Pasienter må ha gjennomgått enten total mastektomi eller brystbevarende kirurgi (lumpektomi).
- For pasienter som gjennomgår lumpektomi, må marginene til den resekerte prøven være histologisk fri for invasiv tumor og ductal carcinoma in situ (DCIS) som bestemt av den lokale patologen. Hvis patologisk undersøkelse viser tumor ved reseksjonslinjen, må ytterligere operative prosedyrer utføres for å oppnå klare marginer. Hvis svulsten fortsatt er tilstede ved den resekerte marginen etter re-eksisjon(er), må pasienten gjennomgå total mastektomi for å være kvalifisert. (Pasienter med marginer positive for lobulært karsinom in situ [LCIS] er kvalifisert uten ytterligere reseksjon.)
- For pasienter som gjennomgår mastektomi, må marginene være histologisk fri for invasiv tumor og DCIS.
Pasienter må ha fullført en av følgende prosedyrer for evaluering av patologisk nodalstatus:
- Sentinel lymfadenektomi alene hvis patologisk nodal staging basert på sentinel lymfadenektomi er pN0, pN1mi eller pN1b;
- Sentinel lymfadenektomi alene hvis patologisk nodal stadie basert på sentinel lymfadenektomi er pN1a begrenset til 1 eller 2 positive noder og primærtumor er T1 eller T2 ved patologisk evaluering;
- Sentinel lymfadenektomi etterfulgt av fjerning av ytterligere non-sentinel lymfeknuter hvis sentinel node (SN) er positiv; eller
- Aksellær lymfadenektomi med eller uten SN-isoleringsprosedyre.
- Intervallet mellom siste operasjon for brystkreft (behandling eller stadieinndeling) og randomisering må ikke være mer enn 84 dager.
- Pasienter må få utført ER-analyse på primærtumoren før randomisering. Brystkreft må vurderes for ER-status i henhold til gjeldende ASCO/CAP Guideline Recommendations for hormonreseptortesting. Hvis negativ for ER, må vurdering av PgR også utføres i henhold til gjeldende ASCO/CAP Guideline Recommendations for hormonreseptortesting. (Enten en kjernebiopsi eller kirurgisk reseksjonsprøve kan brukes til ER/PgR-testing.)
De siste postoperative blodtellingene, utført innen 6 uker før randomisering, må oppfylle følgende kriterier:
- absolutt nøytrofiltall (ANC) må være større enn eller lik 1200/mm3;
- antall blodplater må være større enn eller lik 100 000/mm3; og
- hemoglobin må være større enn eller lik 10 g/dL.
Følgende kriterier for bevis på adekvat leverfunksjon må oppfylles basert på resultatene av de siste postoperative testene utført innen 6 uker før randomisering:
- total bilirubin må være mindre enn eller lik øvre normalgrense (ULN) for laboratoriet med mindre pasienten har en bilirubinøkning større enn ULN til 1,5 x ULN på grunn av Gilberts sykdom eller lignende syndrom som involverer langsom konjugering av bilirubin; og
- alkalisk fosfatase må være mindre enn eller lik 2,5 x ULN for laboratoriet; og
- aspartattransaminase (AST) må være mindre enn eller lik 1,5 x ULN for laboratoriet.
- Alkalisk fosfatase og AST kan ikke begge være høyere enn ULN. For eksempel, hvis den alkaliske fosfatasen er større enn ULN, men mindre enn eller lik 2,5 x ULN, må AST være mindre enn eller lik ULN. Hvis AST er større enn ULN, men mindre enn eller lik 1,5 x ULN, må den alkaliske fosfatasen være mindre enn eller lik ULN.
- Merk: Hvis alaninaminotransferase (ALT) utføres i stedet for AST (per institusjonens standardpraksis), må ALT-verdien være mindre enn eller lik 1,5 x ULN; hvis begge ble utført, må AST være mindre enn eller lik 1,5 x ULN.
- Pasienter med ASAT eller alkalisk fosfatase høyere enn ULN er kvalifisert for inkludering i studien hvis leveravbildning (CT, MR, PET-CT eller PET-skanning utført innen 90 dager før randomisering) ikke viser metastatisk sykdom og kravene til tilstrekkelig leverfunksjon. funksjon som beskrevet ovenfor er oppfylt.
- Pasienter med alkalisk fosfatase som er høyere enn ULN, men mindre enn eller lik 2,5 x ULN er kvalifisert for inkludering i studien hvis en beinskanning, PET-CT-skanning eller PET-skanning utført innen 90 dager før randomisering ikke viser metastatisk sykdom .
- Det siste postoperative serumkreatinin utført innen 6 uker før randomisering må være mindre enn eller lik ULN for laboratoriet.
- Vurdering av venstre ventrikkel ejeksjonsfraksjon (LVEF) med 2-D ekkokardiogram eller multigated acquisition (MUGA) skanning må utføres innen 90 dager før randomisering. LVEF må være større enn eller lik 50 % uavhengig av anleggets nedre normalgrense (LLN). (Hvis anlegget som utfører vurderingen ikke har rapportert LVEF som et helt tall, skal desimaler rapportert som større enn eller lik 5 rundes opp og desimaler rapportert som mindre enn 5 skal rundes ned.)
Ekskluderingskriterier:
Pasienter med en eller flere av følgende tilstander er ikke kvalifisert for denne studien.
- T4-svulster inkludert inflammatorisk brystkreft.
- Definitiv klinisk eller radiologisk bevis på metastatisk sykdom. (Brystavbildning [obligatorisk for alle pasienter] og annen bildebehandling [hvis nødvendig] må ha blitt utført innen 90 dager før randomisering.)
- Synkron eller tidligere kontralateral invasiv brystkreft. (Pasienter med synkron og/eller tidligere kontralateral DCIS er kvalifisert.)
- Enhver historie med ipsilateral invasiv brystkreft eller ipsilateral DCIS.
- Anamnese med ikke-brystmaligniteter innen 5 år før randomisering, bortsett fra følgende: karsinom in situ i livmorhalsen, kolorektal karsinom in situ, melanom in situ og basalcelle- og plateepitelkarsinomer i huden.
- Tidligere terapi med antracykliner eller taxaner for enhver malignitet.
- Kjemoterapi gitt for den nåværende diagnostiserte brystkreften før randomisering.
- Fortsatt endokrin terapi som raloxifen eller tamoxifen (eller annen SERM) eller en aromatasehemmer. Pasienter er kvalifisert hvis disse medisinene seponeres før randomisering.
- Enhver kjønnshormonell terapi, for eksempel p-piller, ovariehormonerstatningsterapi. Pasienter er kvalifisert hvis disse medisinene seponeres før randomisering.
- Kjent aktiv hepatitt B eller hepatitt C med unormale leverfunksjonstester.
Hjertesykdom (historie med og/eller aktiv sykdom) som vil utelukke bruk av legemidlene som inngår i behandlingsregimene. Dette inkluderer, men er ikke begrenset til:
- Aktiv hjertesykdom
- angina pectoris som krever bruk av anti-anginal medisin;
- ventrikulære arytmier bortsett fra benigne premature ventrikulære sammentrekninger;
- supraventrikulære og nodale arytmier som krever pacemaker eller ikke kontrolleres med medisiner;
- ledningsavvik som krever pacemaker;
- klaffesykdom med dokumentert kompromiss i hjertefunksjon;
- symptomatisk perikarditt.
- Historie med hjertesykdom
- hjerteinfarkt dokumentert av forhøyede hjerteenzymer eller vedvarende regionale veggavvik ved vurdering av venstre ventrikkelfunksjon;
- historie med dokumentert kongestiv hjertesvikt (CHF);
- dokumentert kardiomyopati.
- Helbryststrålebehandling (RT) før randomisering eller delvis bryst-RT som ikke kan fullføres på eller før randomiseringsdatoen.
- Iboende lungesykdom som resulterer i dyspné.
- Ustabil diabetes mellitus.
- Aktiv infeksjon eller kronisk infeksjon som krever undertrykkende antibiotika.
- Anamnese med en større organallograft eller tilstand som krever kronisk immunsuppresjon, f.eks. nyre, lever, lunge, hjerte, benmargstransplantasjon eller autoimmune sykdommer. (Pasienter som har mottatt hornhinnetransplantasjoner, kadaverhud eller beintransplantasjoner er kvalifisert.)
- Nervesystemlidelse (parestesi, perifer motorisk nevropati eller perifer sensorisk nevropati) større enn eller lik grad 2, i henhold til NCI CTCAE v4.0.
- Tilstander som forbyr administrering av kortikosteroider.
- Kronisk daglig behandling med kortikosteroider (dose større enn eller lik 10 mg/dag metylprednisolonekvivalent) (unntatt inhalasjonssteroider).
- Anamnese med overfølsomhetsreaksjon på legemidler formulert med polysorbat 80.
- Graviditet eller amming ved studiestart. (Merk: Graviditetstesting må utføres innen 2 uker før randomisering i henhold til institusjonelle standarder for kvinner i fertil alder.)
- Annen ikke-malign systemisk sykdom som ville utelukke pasienten fra å motta studiebehandling eller ville forhindre nødvendig oppfølging.
- Psykiatriske eller vanedannende lidelser eller andre tilstander som etter utrederens oppfatning vil hindre pasienten i å oppfylle studiekravene.
- Bruk av ethvert undersøkelsesprodukt innen 30 dager før randomisering.
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Aktiv komparator: Arm 1: Antracyklinbasert kjemoterapi
4 antracyklinbaserte kjemoterapiregimer (regimer A, B, C eller D). Regim A (TAC): 75 mg/m2 docetaksel (T) + 50 mg/m2 doksorubicin (A) + 500 mg/m2 cyklofosfamid (C) IV hver 3. uke i 6 sykluser. Regime B (AC deretter WP): 60 mg/m2 doksorubicin (A) + 600 mg/m2 cyklofosfamid (C) hver 3. uke i 4 sykluser etterfulgt av ukentlig paklitaksel (WP) 80 mg/m2 IV hver uke i 12 doser. Regim C (DD AC deretter WP): 60 mg/m2 doksorubicin + 600 mg/m2 cyklofosfamid hver 2. uke i 4 sykluser etterfulgt av ukentlig paklitaksel 80 mg/m2 IV hver uke i 12 doser. Regim D (DD AC deretter DD P): 60 mg/m2 doksorubicin + 600 mg/m2 cyklofosfamid hver 2. uke i 4 sykluser etterfulgt av paklitaksel (P) 175 mg/m2 IV hver 2. uke i 4 sykluser. |
Andre navn:
|
|
Aktiv komparator: Arm 2: docetaksel + cyklofosfamid
TC: 75 mg/m2 docetaxel og 600 mg/m2 cyklofosfamid IV hver 3. uke i 6 sykluser
|
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Invasiv sykdomsfri overlevelse (IDFS)
Tidsramme: Vurderes før hver syklus med kjemoterapi, 3-4 uker etter fullført kjemoterapi, hver 6. måned gjennom 5 år og årlig 6-10.
|
Tiden til lokalt residiv etter mastektomi, invasivt lokalt residiv i det ipsilaterale brystet etter lumpektomi, regionalt residiv, fjernt residiv, invasiv kontralateral brystkreft, andre primære kreft (annet enn plateepitel- eller basalcellekarsinom i huden, melanom in situ, karsinom i situ av livmorhalsen, kolorektalt karsinom in situ eller lobulært karsinom in situ i brystet), eller død av en hvilken som helst årsak før tilbakefall eller andre primære kreft.
|
Vurderes før hver syklus med kjemoterapi, 3-4 uker etter fullført kjemoterapi, hver 6. måned gjennom 5 år og årlig 6-10.
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Sykdomsfri overlevelse (DFS-DCIS)
Tidsramme: Vurderes før hver syklus med kjemoterapi, 3-4 uker etter fullført kjemoterapi, hver 6. måned gjennom 5 år og årlig 6-10.
|
Tiden til lokalt residiv etter mastektomi, lokalt residiv i det ipsilaterale brystet etter lumpektomi (invasiv eller ikke-invasiv), regionalt residiv, fjernt residiv, kontralateral brystkreft (invasiv eller ikke-invasiv), andre primærkreft (annet enn plateepitelkreft eller basalkreft) cellekarsinom i huden, melanom in situ, karsinom in situ i livmorhalsen, kolorektalt karsinom in situ eller lobulært karsinom in situ i brystet), eller død av en hvilken som helst årsak før tilbakefall eller andre primære kreft.
|
Vurderes før hver syklus med kjemoterapi, 3-4 uker etter fullført kjemoterapi, hver 6. måned gjennom 5 år og årlig 6-10.
|
|
Total overlevelse (OS)
Tidsramme: Vurderes før hver syklus med kjemoterapi, 3-4 uker etter fullført kjemoterapi, hver 6. måned gjennom 5 år og årlig 6-10.
|
Tid fra randomisering til død uansett årsak.
|
Vurderes før hver syklus med kjemoterapi, 3-4 uker etter fullført kjemoterapi, hver 6. måned gjennom 5 år og årlig 6-10.
|
|
Gjentaksfritt intervall (RFI)
Tidsramme: Vurderes før hver syklus med kjemoterapi, 3-4 uker etter fullført kjemoterapi, hver 6. måned gjennom 5 år og årlig 6-10.
|
Tid fra randomisering til lokal, regional eller fjern gjentakelse.
|
Vurderes før hver syklus med kjemoterapi, 3-4 uker etter fullført kjemoterapi, hver 6. måned gjennom 5 år og årlig 6-10.
|
|
Toksisitet av hver diett
Tidsramme: Vurderes før hver syklus med kjemoterapi, 3-4 uker etter fullført kjemoterapi, hver 6. måned gjennom 5 år og årlig 6-10.
|
Frekvenser av uønskede hendelser kategorisert ved hjelp av NCI Common Terminology Criteria for Adverse Events (CTCAE) v4.0.
|
Vurderes før hver syklus med kjemoterapi, 3-4 uker etter fullført kjemoterapi, hver 6. måned gjennom 5 år og årlig 6-10.
|
|
Molekylære prediktorer for effekt
Tidsramme: Vevsprøve tatt ved operasjonstidspunktet
|
Å utvikle prediktive markører for nytte av doksorubicin.
|
Vevsprøve tatt ved operasjonstidspunktet
|
Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Samarbeidspartnere
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart
1. april 2012
Primær fullføring (Forventet)
1. mai 2022
Studiet fullført (Forventet)
1. november 2023
Datoer for studieregistrering
Først innsendt
6. mars 2012
Først innsendt som oppfylte QC-kriteriene
6. mars 2012
Først lagt ut (Anslag)
8. mars 2012
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
14. april 2022
Siste oppdatering sendt inn som oppfylte QC-kriteriene
13. april 2022
Sist bekreftet
1. april 2022
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Ytterligere relevante MeSH-vilkår
- Hudsykdommer
- Neoplasmer
- Neoplasmer etter nettsted
- Bryst sykdommer
- Brystneoplasmer
- Fysiologiske effekter av legemidler
- Molekylære mekanismer for farmakologisk virkning
- Enzymhemmere
- Antirevmatiske midler
- Antineoplastiske midler
- Immunsuppressive midler
- Immunologiske faktorer
- Tubulin modulatorer
- Antimitotiske midler
- Mitosemodulatorer
- Antineoplastiske midler, Alkylering
- Alkyleringsmidler
- Myeloablative agonister
- Antineoplastiske midler, fytogene
- Topoisomerase II-hemmere
- Topoisomerasehemmere
- Antibiotika, antineoplastisk
- Docetaxel
- Cyklofosfamid
- Paklitaksel
- Doxorubicin
Andre studie-ID-numre
- NSABP-B-49
- NCI-2012-00701 (Registeridentifikator: CTRP (Clinical Trials Reporting Program))
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .
Kliniske studier på Brystkreft
-
Tianjin Medical University Cancer Institute and...Guangxi Medical University; Sun Yat-sen University; Chinese PLA General Hospital og andre samarbeidspartnereFullførtThe Clinical Application Guide of Conebeam Breast CTKina
-
Novartis PharmaceuticalsFullførtMetastatisk brystkreft (MBC) | Locally Advance Breast Cancer (LABC)Storbritannia, Spania
-
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.UkjentHR-positiv, HER2-negativ og PIK3CA Mutation Advanced Breast CancerKina
-
Cancer Institute and Hospital, Chinese Academy...Har ikke rekruttert ennå
-
Emory UniversityNational Cancer Institute (NCI)TilbaketrukketPrognostisk stadium IV brystkreft AJCC v8 | Metastatisk malign neoplasma i hjernen | Metastatisk brystkarsinom | Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8
-
NRG OncologyNational Cancer Institute (NCI)FullførtAnatomisk stadium IV brystkreft AJCC v8 | Prognostisk stadium IV brystkreft AJCC v8 | Metastatisk malign neoplasma i beinet | Metastatisk malign neoplasma i lymfeknutene | Metastatisk malign neoplasma i leveren | Metastatisk brystkarsinom | Metastatisk malign neoplasma i lungen | Metastatisk malign neoplasma... og andre forholdForente stater, Canada, Saudi-Arabia, Sør -Korea
-
Fondazione IRCCS Istituto Nazionale dei Tumori,...Fondazione Policlinico Universitario Agostino Gemelli IRCCS; Fondazione... og andre samarbeidspartnereRekrutteringBrystkreft | Brystneoplasmer | Bryst sykdommer | Neoplasma i brystet | Brystsvulster | Brystkarsinom | Brystneoplasmer, mannlige | Brystkreft stadium IV | Hormonreseptorpositiv ondartet neoplasma i brystet | HR-positiv brystkreft | Hormonreseptorpositivt brystkarsinom | Hormonreseptor (HR)-positiv brystkreft | Hormonreseptorpositiv... og andre forholdItalia
-
University of California, DavisNational Cancer Institute (NCI)RekrutteringAnatomisk stadium III brystkreft AJCC v8 | Avansert malignt solid neoplasma | Stadium III lungekreft AJCC v8 | Stadium IV lungekreft AJCC v8 | Stadium III nyrecellekreft AJCC v8 | Stadium IV nyrecellekreft AJCC v8 | Klinisk stadium III kutant melanom AJCC v8 | Trinn IV tykktarmskreft AJCC v8 | Klinisk stadium... og andre forholdForente stater
Kliniske studier på Docetaxel
-
Tianjin Medical University Cancer Institute and...Rekruttering
-
Optimal Health ResearchFullførtBrystkreft | Lungekreft | ProstatakreftForente stater
-
Instituto do Cancer do Estado de São PauloHar ikke rekruttert ennå
-
Zhuhai Beihai Biotech Co., LtdFullførtSolide svulster | Bioekvivalens | DocetaxelIndia
-
Jiangsu HengRui Medicine Co., Ltd.Shanghai Pulmonary Hospital, Shanghai, ChinaFullførtIkke-småcellet lungekreft (NSCLC)Kina
-
AkesoRekrutteringIkke-småcellet lungekreftKina
-
Fudan UniversityHar ikke rekruttert ennåAvansert ikke-småcellet lungekreft
-
Jiangsu HengRui Medicine Co., Ltd.Shanghai Pulmonary Hospital, Shanghai, ChinaAvsluttetIkke plateepitel, ikke småcellet lungeKina
-
Hunan Cancer HospitalChia Tai Tianqing Pharmaceutical Group Co., Ltd.; Hunan Provincial People...UkjentIkke-småcellet lungekreftKina