Impact of Cooking Process on Meat Protein Digestion and Metabolism

September 11, 2012 updated by: Robert Benamouzig, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Few is known on meat protein digestibility in humans and the impact of cooking process, while excessive intake of processed meat has been suggested to increase the risk of colorectal cancer.

This study aims to measure in vivo in humans the real digestibility of beef meat proteins depending 2 cooking processes, using ileal tubes and stable isotopes.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Anticipated)

48

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Bobigny, France, 93
        • Recruiting
        • Centre de Recherche sur Volontaires
        • Contact:
        • Principal Investigator:
          • Robert Benamouzig, MD, PhD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 45 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Healthy
  • BMI between 18 an 27
  • Age between 18 and 45 years

Exclusion Criteria:

  • Gastrointestinal or liver pathology
  • Diabetes
  • Pregnancy
  • Vegetarian

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: intense cooking process
Test meal: 150g of beef cooked at intense temperature. Beef proteins are intrinsically labelled with 15 N protein
Dietary supplement: Test meal
test meal is 150 g of beef cooked either at moderate or high intensity. Proteins are intrinsically labelled with 15N.
Experimental: mild cooking process
Test meal: 150 g of beef cooked at moderate intensity. Beef proteins are intrinsically labeled with 15N.
Dietary supplement: Test meal
test meal is 150 g of beef cooked either at moderate or high intensity. Proteins are intrinsically labelled with 15N.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
protein digestibility
Time Frame: single measure
From ileal recovery of the ingested tracer during 8 h after the meal
single measure

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
nitrogen metabolism
Time Frame: single measure
Distribution of dietary nitrogen throug metabolic pools
single measure

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Collaborators

National Research Agency, France

Investigators

  • Study Director: Claire Gaudichon, PhD, INRA AgroParisTech

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

February 1, 2012

Primary Completion (Actual)

September 1, 2012

Study Registration Dates

First Submitted

March 21, 2012

First Submitted That Met QC Criteria

September 11, 2012

First Posted (Estimate)

September 14, 2012

Study Record Updates

Last Update Posted (Estimate)

September 14, 2012

Last Update Submitted That Met QC Criteria

September 11, 2012

Last Verified

September 1, 2012

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • PRONUTRIAL

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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