Is There a Relationship Between Previous Exposure to General Anesthesia and the Development of Alzheimer´s Disease? (DEMA)

March 24, 2016 updated by: Anna-Karin Strand, MD, University Hospital, Linkoeping

A Case-control Study of Exposure to General Anesthesia and a Diagnosis of Alzheimer´s Disease Later in Life.

The purpose of this study is to compare exposure to general anesthesia between cases with a diagnosis of Alzheimer´s disease and controls without diagnosis, through studies of medical records. The investigators wish to explore if there is a relationship between exposure to general anesthesia and the development of Alzheimer´s disease.

Study Overview

Status

Unknown

Study Type

Observational

Enrollment (Actual)

877

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

      • Linkoping, Sweden, 58185
        • University Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • ADULT
  • OLDER_ADULT
  • CHILD

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Cases from a regional Alzheimer´s disease record. Matched controls from the national population register.

Description

Inclusion Criteria:

  • Clinical diagnosis of Alzheimer´s disease
  • Previous exposure to anesthesia

Exclusion Criteria:

  • Inability to retrieve medical records

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Exposure to general anesthesia
Time Frame: Up to 20 years in retrospect
Up to 20 years in retrospect

Secondary Outcome Measures

Outcome Measure
Time Frame
Exposure to inhaled anesthetics
Time Frame: Up to 20 years in retrospect
Up to 20 years in retrospect

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Investigators

  • Study Chair: Christina Eintrei, professor, University Hospital Linköping

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2012

Primary Completion (ANTICIPATED)

July 1, 2016

Study Completion (ANTICIPATED)

July 1, 2016

Study Registration Dates

First Submitted

September 27, 2012

First Submitted That Met QC Criteria

September 27, 2012

First Posted (ESTIMATE)

September 28, 2012

Study Record Updates

Last Update Posted (ESTIMATE)

March 25, 2016

Last Update Submitted That Met QC Criteria

March 24, 2016

Last Verified

March 1, 2016

More Information

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on General Anesthesia

3
Subscribe