- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01707017
The Effects of Low- and High-intensity Resistance Exercise on Force-velocity Characteristics in Older Adults
February 19, 2013 updated by: Universitaire Ziekenhuizen KU Leuven
The purpose of this study is to compare the impact of high- and low-intensity resistance exercise on force-velocity characteristics, muscle mass and inflammatory processes in older adults.
As all training protocols are designed to end with maximal effort, effects are expected to be similar between groups.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
56
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Leuven, Belgium, 3001
- Faculty of Kinesiology and Rehabilitation Sciences
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
60 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- age 60 to 80 years
Exclusion Criteria:
- Knee or hip prothesis
- Systematic training
- Cardiovascular disease
- Acute lower back pain
- Dementia
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Active Comparator: High-load strength training
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Active Comparator: Low-load strength training
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Active Comparator: Low-load + moderate-load strength training
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
|---|---|
|
Change in force-velocity characteristics of knee extensors
Time Frame: Baseline, 12weeks, 6 months
|
Baseline, 12weeks, 6 months
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Change in muscle volume
Time Frame: Baseline, 12weeks, 6 months
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Baseline, 12weeks, 6 months
|
|
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Change in maximal strength (one repetition maximum)
Time Frame: Baseline, 4weeks, 8weeks, 12weeks, 6 months
|
Strength is measured as the maximum weight on the training equipment that can be lifted only one time (= one repetition maximum).
|
Baseline, 4weeks, 8weeks, 12weeks, 6 months
|
|
Change in motivation
Time Frame: Baseline, every week for 12 weeks, 6 months
|
Baseline, every week for 12 weeks, 6 months
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|
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Change in physical activity
Time Frame: Baseline, 12weeks, 6 months
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Baseline, 12weeks, 6 months
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|
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Change in inflammatory markers in blood
Time Frame: Baseline, 12weeks, 6 months
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Baseline, 12weeks, 6 months
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Van Roie E, Walker S, Van Driessche S, Baggen R, Coudyzer W, Bautmans I, Delecluse C. Training load does not affect detraining's effect on muscle volume, muscle strength and functional capacity among older adults. Exp Gerontol. 2017 Nov;98:30-37. doi: 10.1016/j.exger.2017.07.017. Epub 2017 Aug 1.
- Nuvagah Forti L, Van Roie E, Njemini R, Coudyzer W, Beyer I, Delecluse C, Bautmans I. High Versus Low Load Resistance Training: The Effect of 24 Weeks Detraining on Serum Brain Derived-Neurotrophic Factor (BDNF) in Older Adults. J Frailty Aging. 2017;6(1):53-58. doi: 10.14283/jfa.2017.2.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2012
Primary Completion (Actual)
December 1, 2012
Study Registration Dates
First Submitted
October 2, 2012
First Submitted That Met QC Criteria
October 12, 2012
First Posted (Estimate)
October 15, 2012
Study Record Updates
Last Update Posted (Estimate)
February 20, 2013
Last Update Submitted That Met QC Criteria
February 19, 2013
Last Verified
November 1, 2011
More Information
Terms related to this study
Other Study ID Numbers
- S53709
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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