- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01709110
VERtebral Fracture Treatment Comparisons in Osteoporotic Women (VERO)
Teriparatide and Risedronate in the Treatment of Patients With Severe Postmenopausal Osteoporosis: Comparative Effects on Vertebral Fractures
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Phase 4
Contacts and Locations
Study Locations
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Buenos Aires, Argentina, C1128AAF
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Caba, Argentina, C1425AGC
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Mar Del Plata, Argentina, B7600DHK
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Graz, Austria, 8036
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Hohenems, Austria, 6845
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Linz, Austria, 4020
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Vienna, Austria, A-1060
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Brussels, Belgium, 1070
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Genk, Belgium, 3600
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Gent, Belgium, 9000
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Gilly, Belgium, 6060
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Laken, Belgium, 1020
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Leuven, Belgium, 3000
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Liège, Belgium, 4020
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Merksem, Belgium, 2170
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Mons, Belgium, 7000
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Brasilia, Brazil, 71625-009
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Rio De Janeiro, Brazil, 22271-100
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São Paulo, Brazil, 05437-010
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British Columbia
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Kelowna, British Columbia, Canada, V1Y3G5
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Vancouver, British Columbia, Canada, V5Z 4E1
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Nova Scotia
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Halifax, Nova Scotia, Canada, B3H 1V7
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Ontario
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Hamilton, Ontario, Canada, L8N 1Y2
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Toronto, Ontario, Canada, M5G 2C4
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Quebec
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Montreal, Quebec, Canada, H3T 1E2
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Sainte-Foy, Quebec, Canada, G1V 3M7
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Trois-Rivieres, Quebec, Canada, G8Z 1Y2
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Saskatchewan
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Saskatoon, Saskatchewan, Canada, S7K 0H6
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Ceske Budejovice, Czechia, 37005
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Klatovy, Czechia, 33938
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Prague, Czechia, 128 08
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Uherske Hradiste, Czechia, 686 01
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Caen, France, 14033
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La Crau, France, 83260
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Lyon, France, 69003
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Orleans, France, 45032
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Saint-Etienne, France, 42055
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Toulouse, France, 31059
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Dresden, Germany, 01067
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Frankfurt, Germany, 60528
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Hamburg, Germany, 22415
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Leipzig, Germany, 04103
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Magdeburg, Germany, 39110
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Marburg, Germany, 35043
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Athens, Greece, 10676
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Kifissia, Greece, 14561
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Patras, Greece, 26500
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Thessaloniki, Greece, 54642
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Budapest, Hungary, 1094
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Debrecen, Hungary, 4043
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Eger, Hungary, 3300
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Kaposvar, Hungary, 7400
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Szeged, Hungary, 6720
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Firenze, Italy, 50134
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Genova-Nervi, Italy, 16167
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Orbassano, Italy, 10043
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Padova, Italy, 35128
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Rome, Italy, 00161
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Torino, Italy, 10126
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Valeggio Sul Mincio, Italy, 37067
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Bialystok, Poland, 15-351
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Elblag, Poland, 82-300
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Lublin, Poland, 20-582
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Poznan, Poland, 60-218
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Swidnik, Poland, 21-040
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Warsaw, Poland, 02-118
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San Juan, Puerto Rico, 00918
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Alcira, Spain, 46600
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Barcelona, Spain, 08025
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Cadiz, Spain, 11009
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Madrid, Spain, 28046
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Sabadell, Spain, 08208
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Valencia, Spain, 46026
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Alabama
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Birmingham, Alabama, United States, 35294
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California
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Concord, California, United States, 94520
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Fresno, California, United States, 93720
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Laguna Hills, California, United States, 92653
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Lancaster, California, United States, 93534
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Tustin, California, United States, 92780
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Colorado
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Lakewood, Colorado, United States, 80227
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Connecticut
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Danbury, Connecticut, United States, 06810
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Florida
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Orlando, Florida, United States, 32804
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Georgia
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Gainesville, Georgia, United States, 30501
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Indiana
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Evansville, Indiana, United States, 47714
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Indianapolis, Indiana, United States, 46202
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Kansas
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Topeka, Kansas, United States, 66606
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Maryland
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Bethesda, Maryland, United States, 20817
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Michigan
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Detroit, Michigan, United States, 48202
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Nebraska
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Omaha, Nebraska, United States, 68131
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New Jersey
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Clifton, New Jersey, United States, 07012
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Freehold, New Jersey, United States, 07728
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New Mexico
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Albuquerque, New Mexico, United States, 87106
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North Carolina
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Asheville, North Carolina, United States, 28803
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Greensboro, North Carolina, United States, 27408
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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North Dakota
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Fargo, North Dakota, United States, 58103
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Oregon
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Bend, Oregon, United States, 97701
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Pennsylvania
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Duncansville, Pennsylvania, United States, 16635
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Pittsburgh, Pennsylvania, United States, 15213
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Wyomissing, Pennsylvania, United States, 19610
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Texas
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Dallas, Texas, United States, 75231
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Washington
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Seattle, Washington, United States, 98122
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Spokane, Washington, United States, 99204
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Wisconsin
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Madison, Wisconsin, United States, 53705
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Postmenopausal women with osteoporosis, as defined by low bone mineral density (BMD), i.e. anterior-posterior lumbar spine, total hip or femoral neck BMD ≥1.5 standard deviations below the average BMD for young, healthy, non-Hispanic, Caucasian women
- A minimum of 2 moderate or 1 severe vertebral fragility fractures (confirmed by central reader) were required
Exclusion Criteria:
- Increased risk of osteosarcoma
- History of unresolved skeletal diseases that affect bone metabolism
- History of atypical subtrochanteric or diaphyseal femoral fractures
- Abnormally high or low calcium levels
- Abnormally high parathyroid hormone (PTH) levels
- Severe vitamin D deficiency
- Abnormal thyroid function not corrected by therapy
- History of malignant neoplasms in the last 5 years
- Active liver disease, clinical jaundice
- Significant impairment of hepatic or renal function
- History of nephro- or urolithiasis
- Previous or planned kypho- or vertebroplasty
- Active or risk for osteonecrosis of the jaw
- Active or recent history of upper gastrointestinal disorders
- Unable to stand or sit in the upright position for at least 30 minutes
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Teriparatide
Teriparatide 20 microgram (µg) administered by subcutaneous (SC) injection once daily for 24 months. Placebo given orally once weekly for 24 months. Elemental Calcium 500 to 1000 milligram per day and Vitamin D 400 to 800 International Units per day, both administered orally once daily while receiving treatment. |
Administered SC
Other Names:
Administered orally
Teriparatide arm placebo administered orally. Risedronate arm placebo administered SC.
Administered orally
|
Active Comparator: Risedronate
Risedronate 35 milligram (mg) administered orally once weekly for 24 months. Placebo given by SC injection once daily for 24 months. Elemental Calcium 500 to 1000 milligram per day and Vitamin D 400 to 800 International Units per day, both administered orally once daily while receiving treatment. |
Administered orally
Administered orally
Teriparatide arm placebo administered orally. Risedronate arm placebo administered SC.
Administered orally
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Proportion of Participants With New Vertebral Fractures
Time Frame: Baseline through 24 Months
|
The incidence of new vertebral fractures was assessed by quantitative vertebral morphometry measurements (QM) with qualitative visual semiquantitative grading (SQ) confirmation. A new vertebral fracture was diagnosed in a vertebra that was non-fractured at the baseline radiological examination. It was defined as a loss of vertebral body height of at least 20% and 4 mm from the baseline radiograph by vertebral QM, based upon placement of six points by a trained, central reader. Any fractures identified by QM were confirmed using SQ: if the vertebral body also had an increase of one or more severity grade, it was considered an incident vertebral fracture. |
Baseline through 24 Months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Proportion of Participants With Pooled New and Worsening Vertebral Fractures
Time Frame: Baseline through 24 Months
|
Worsening of a pre-existing fracture was considered if the decrease in vertebral height was at least one severity grade in the semi-quantitative assessment, confirmed by a trained central reader, where vertebrae were graded as normal (SQ0) or as with mild (SQ1), moderate (SQ2), or severe (SQ3) fractures, defined as ~20 to 25% (mild), ~25 to 40% (moderate) or ~40% or more (severe) decrease in anterior, central, or posterior vertebral height (T4 to L4).
|
Baseline through 24 Months
|
Proportion of Participants With Pooled Clinical Vertebral and Non-Vertebral Fragility Fractures
Time Frame: Baseline through 24 Months
|
A clinical vertebral fracture was defined as a new or worsening vertebral fracture, confirmed by radiography, that was associated with signs and symptoms highly suggestive of a vertebral fracture. All non-vertebral fractures that occurred and were diagnosed between visits required the confirmation by the site investigators after evaluating the original x-ray film(s), the radiology or surgical report. For clinical vertebral fractures, the final confirmation of the diagnosis required the centralized evaluation by a trained, independent reader. |
Baseline through 24 Months
|
Proportion of Participants With Non-Vertebral Fragility Fractures
Time Frame: Baseline through 24 Months
|
A non-vertebral fracture is a fracture at any of the following non-vertebral sites: clavicle, scapula, ribs, sternum, sacrum, coccyx, humerus, radius, ulna, carpus, pelvis, hip, femur, patella, tibia, fibula, ankle, calcaneus, tarsus, and metatarsal.
Non-vertebral fractures were determined by direct questioning at each visit, and confirmed by the site investigators by x-ray, radiology or surgical report.
Fractures resulting from a severe trauma such as a traffic collision, a beating, or having been struck by a falling or moving object were not considered fragility fractures but traumatic fractures.
|
Baseline through 24 Months
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Proportion of Participants With Major Non-Vertebral Fragility Fractures
Time Frame: Baseline through 24 Months
|
A major non-vertebral fracture is a fracture at any of the following non-vertebral sites hip, radius, humerus, ribs, pelvis, tibia and femur.
Non-vertebral fractures were determined by direct questioning at each visit, and confirmed by the site investigators by x-ray, radiology or surgical report.
Fractures resulting from a severe trauma such as a traffic collision, a beating, or having been struck by a falling or moving.
|
Baseline through 24 Months
|
Proportion of Participants With New Moderate and/or Severe Vertebral Fractures
Time Frame: Baseline through 24 Months
|
Vertebrae were graded as moderate (SQ2), or severe (SQ3) fractures, based on ~25 to 40% (moderate) or ~40% or more (severe) decrease in anterior, central, or posterior vertebral height (T4 through L4).
|
Baseline through 24 Months
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Proportion of Participants With New Multiple (2 or More) Vertebral Fractures
Time Frame: Baseline through 24 Months
|
Baseline through 24 Months
|
|
Proportion of Participants With Pooled Fragility and Traumatic Non-Vertebral Fractures
Time Frame: Baseline through 24 Months
|
Traumatic fractures were considered if resulting from a severe trauma such as a traffic collision, a beating, or having been struck by a falling or moving object.
|
Baseline through 24 Months
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Change From Baseline to 24 Months Endpoint in Height
Time Frame: Baseline, 24 Months
|
Baseline, 24 Months
|
|
Change From Baseline to 24 Months Endpoint in Back Pain Using an 11-point Numerical Pain Rating Scale
Time Frame: Baseline, 24 Months
|
Participants rated the worst back pain during the 24 hours preceding the visit at baseline and each post-baseline visit.
An 11-point numerical back pain rating scale (rated from 0 = no back pain to 10 = worst possible back pain) was used.
|
Baseline, 24 Months
|
Change From Baseline to 24 Months Endpoint in the European Quality of Life Questionnaire [EQ-5D-5L] (UK)
Time Frame: Baseline, 24 Months
|
The EQ-5D-5L is a generic, multidimensional, health-related, quality-of-life instrument completed on five dimensions to measure health-related quality of life.
The profile allowed participants to rate their health state in five health domains: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression using a five level scale (no problems, slight problems, moderate problems, severe problems, and unable to/extreme problems).
The responses are used to derive the health state index scores using the United Kingdom (UK) algorithm, with scores ranging from -0.59 to 1.0.
A higher score indicates better health state.
|
Baseline, 24 Months
|
Change From Baseline to 24 Months Endpoint in the European Quality of Life Questionnaire [EQ-5D-5L] (US)
Time Frame: Baseline, 24 Months
|
The EQ-5D-5L is a generic, multidimensional, health-related, quality-of-life instrument completed on five dimensions to measure health-related quality of life.
The profile allowed participants to rate their health state in five health domains: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression using a five level scale (no problems, slight problems, moderate problems, severe problems, and unable to/extreme problems).
The responses are used to derive the health state index scores using the United States (US) cross walk algorithm, with scores ranging from -0.11 to 1.0.
A higher score indicates better health state.
|
Baseline, 24 Months
|
Collaborators and Investigators
Sponsor
Publications and helpful links
General Publications
- Body JJ, Marin F, Kendler DL, Zerbini CAF, Lopez-Romero P, Moricke R, Casado E, Fahrleitner-Pammer A, Stepan JJ, Lespessailles E, Minisola S, Geusens P. Efficacy of teriparatide compared with risedronate on FRAX(R)-defined major osteoporotic fractures: results of the VERO clinical trial. Osteoporos Int. 2020 Oct;31(10):1935-1942. doi: 10.1007/s00198-020-05463-4. Epub 2020 May 30.
- Geusens P, Kendler DL, Fahrleitner-Pammer A, Lopez-Romero P, Marin F. Distribution of Prevalent and Incident Vertebral Fractures and Their Association with Bone Mineral Density in Postmenopausal Women in the Teriparatide Versus Risedronate VERO Clinical Trial. Calcif Tissue Int. 2020 Jun;106(6):646-654. doi: 10.1007/s00223-020-00683-6. Epub 2020 Mar 10.
- Minisola S, Marin F, Kendler DL, Geusens P, Zerbini CAF, Russo LA, Casado E, Fahrleitner-Pammer A, Stepan JJ, Lespessailles E, Moericke R, Bagur A, Lakatos P, Lopez-Romero P, Body JJ. Serum 25-hydroxy-vitamin D and the risk of fractures in the teriparatide versus risedronate VERO clinical trial. Arch Osteoporos. 2019 Jan 18;14(1):10. doi: 10.1007/s11657-019-0561-x.
- Geusens P, Marin F, Kendler DL, Russo LA, Zerbini CA, Minisola S, Body JJ, Lespessailles E, Greenspan SL, Bagur A, Stepan JJ, Lakatos P, Casado E, Moericke R, Lopez-Romero P, Fahrleitner-Pammer A. Effects of Teriparatide Compared with Risedronate on the Risk of Fractures in Subgroups of Postmenopausal Women with Severe Osteoporosis: The VERO Trial. J Bone Miner Res. 2018 May;33(5):783-794. doi: 10.1002/jbmr.3384. Epub 2018 Feb 9.
- Kendler DL, Marin F, Zerbini CAF, Russo LA, Greenspan SL, Zikan V, Bagur A, Malouf-Sierra J, Lakatos P, Fahrleitner-Pammer A, Lespessailles E, Minisola S, Body JJ, Geusens P, Moricke R, Lopez-Romero P. Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial. Lancet. 2018 Jan 20;391(10117):230-240. doi: 10.1016/S0140-6736(17)32137-2. Epub 2017 Nov 9. Erratum In: Lancet. 2017 Nov 30;: Lancet. 2018 Dec 1;392(10162):2352.
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Metabolic Diseases
- Fractures, Bone
- Wounds and Injuries
- Musculoskeletal Diseases
- Bone Diseases
- Bone Diseases, Metabolic
- Spinal Injuries
- Back Injuries
- Osteoporosis
- Osteoporosis, Postmenopausal
- Spinal Fractures
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Micronutrients
- Membrane Transport Modulators
- Vitamins
- Bone Density Conservation Agents
- Calcium-Regulating Hormones and Agents
- Calcium Channel Blockers
- Vitamin D
- Calcium
- Teriparatide
- Risedronic Acid
Other Study ID Numbers
- 14536
- B3D-EW-GHDW (Other Identifier: Eli Lilly and Company)
- 2012-000123-41 (EudraCT Number)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
IPD Sharing Time Frame
IPD Sharing Access Criteria
IPD Sharing Supporting Information Type
- STUDY_PROTOCOL
- SAP
- CSR
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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