Prevalence of Toxoplasma Gondii and Toxocara Canis Among Patients With Uveitis

April 17, 2013 updated by: Lim, Su Jin, National Institute of Health, Korea

Investigate the prevalence of Toxoplasma gondii and Toxocara canis in Uveitis

  • serum antibody to T. gondii and T. canis
  • PCR with peripheral blood for T. gondii and T. canis
  • PCR with aqueous humor for T. gondii and T. canis
  • Clinical manifestation of patient with uveitis

Study Overview

Status

Completed

Conditions

Detailed Description

Consecutive patients with uveitis are enrolled in Nune Eye Hospital.

Serum ELISA

  • IgM,IgG antibody to Toxoplasma gondii
  • IgG antibody to Toxocara canis

PCR

  • PCR with serum and aqueous humor to Toxoplasma gondii
  • PCR with serum and aqueous humor to Toxocara canis Clinical characteristics
  • visual acuity
  • intraocular pressure (IOP)
  • location and degree of inflammation
  • other fundus findings were recorded

questionnaire

  • environment, occupation
  • pet ownership, exposure to animal
  • history of eating raw liver of animal, raw beef or any other raw flesh of animal.

Study Type

Observational

Enrollment (Actual)

98

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

patient with uveitis

Description

Inclusion Criteria:

  • patients with uveitis

Exclusion Criteria:

  • Patients with history of major ophthalmic surgery within 6 months
  • antiviral, antifungal or antiparasitic therapy within 6 months

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Number of patients with positive result for serum antibody to Toxoplasma gondii and Toxocara canis
Time Frame: at baseline
proportion of patients with seropositive for Toxoplasma gondii and Toxocara canis among patients
at baseline

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Number of patients with positive PCR with peripheral blood and aqueous humor to Toxoplasma gondii and Toxocara canis
Time Frame: at baseline
Proportion of patient with positive PCR to Toxoplasma gondii and Toxocara canis
at baseline

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
location of inflammation and fundus finding
Time Frame: at baseline

location of inflammation

  • anterior or posterior or panuveitis

fundus finding

  • granuloma in macular or periphery retina
  • pigmentation
at baseline
Demographic characteristics
Time Frame: at baseline
  • Gender
  • Residence
  • Pet ownership
  • Habit of eating uncooked meat
at baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

National Institute of Health, Korea

Investigators

  • Principal Investigator: Su Jin Lim, MD, Nune Eye Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2011

Primary Completion (Actual)

February 1, 2012

Study Completion (Actual)

February 1, 2012

Study Registration Dates

First Submitted

April 12, 2013

First Submitted That Met QC Criteria

April 17, 2013

First Posted (Estimate)

April 22, 2013

Study Record Updates

Last Update Posted (Estimate)

April 22, 2013

Last Update Submitted That Met QC Criteria

April 17, 2013

Last Verified

April 1, 2013

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Nuneuveitis

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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