Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis

January 25, 2021 updated by: CHU de Quebec-Universite Laval
This study investigates the variations in the retinal nerve fiber layer (RNFL) thickness during uncomplicated anterior and intermediate uveitis, respectively. The objectives are to 1 ) confirm the RNFL thickening during an uncomplicated anterior uveitis as described in the literature, 2) measure the RNFL thickness during an uncomplicated intermediate uveitis specifically and 3) describe the variation in time of RNFL thickness during the two types of uveitis.

Study Overview

Status

Completed

Conditions

Detailed Description

Thirty six individuals (18 with anterior uveitis and 18 with intermediate uveitis) will be recruited at the Centre universitaire d'ophtalmologie du CHU de Québec. RNFL thickness will be measured with optical coherence tomography at 3 times. For anterior uveitis, the RNFL thickness will be measured at presentation, 1 week and 4 to 6 weeks. For intermediate uveitis, the RNFL thickness will be measured at presentation, 4 to 6 weeks and 4 months. The initial thickness will be studied for each type of uveitis and progression over time will be studied also for each type of uveitis.

Study Type

Observational

Enrollment (Actual)

36

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Canada
      • Québec, Canada, G1S 4LB
        • Centre universitaire d'ophtalmologie, Hôpital du Saint-Sacrement. CHU de Québec

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Adult of 18 years old or more with anterior or intermediate uncomplicated uveitis

Description

Inclusion Criteria:

  • 18 years old or more
  • anterior uncomplicated uveitis or intermediate uncomplicated uveitis

Exclusion Criteria:

  • history of uveitis in the past, other than the actual uveitis
  • history of ophthalmologic pathology with potential impact on retinal nerve fiber layer thickness
  • optic nerve or macular clinically apparent edema
  • history of glaucoma or other optic neuropathy
  • suspected or confirmed multiple sclerosis
  • ocular hypertension (intraocular pressure more than 22 mmHg)
  • reduced optical coherence tomography signal (lower than 7) on the Cirrus HD-OCT

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Retinal Nerve Fiber Layer Thickness in anterior uveitis
Time Frame: At time 0
At time 0
Retinal Nerve Fiber Layer Thickness in intermediate uveitis
Time Frame: At time 0
At time 0
Change from Baseline Retinal Nerve Fiber Layer Thickness in anterior uveitis
Time Frame: at 4 to 6 weeks
at 4 to 6 weeks
Change from Baseline Retinal Nerve Fiber Layer Thickness in intermediate uveitis
Time Frame: at 4 months
at 4 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

CHU de Quebec-Universite Laval

Investigators

  • Principal Investigator: Simon Couture, Doctor, Centre de recherche du CHU de Québec : Université Laval

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ACTUAL)

August 1, 2016

Primary Completion (ACTUAL)

December 1, 2020

Study Completion (ACTUAL)

December 1, 2020

Study Registration Dates

First Submitted

August 4, 2016

First Submitted That Met QC Criteria

August 22, 2016

First Posted (ESTIMATE)

August 25, 2016

Study Record Updates

Last Update Posted (ACTUAL)

January 27, 2021

Last Update Submitted That Met QC Criteria

January 25, 2021

Last Verified

January 1, 2021

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2017-3170

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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