Urine pH and Diet Net Acid Load

July 25, 2017 updated by: University of California, San Francisco

Alterations in Urine pH With Differing Diet Net Acid Loads

Presently, the gold standard for testing diet acid intake is a urine collection done for many hours, usually 24 hours, which must be analyzed in a research lab for "net acid excretion". So, getting information about diet acid intake is difficult. Many people have suggested doing a much simpler test, which is checking the pH of the urine when you wake up. But, no one has studied if this simpler method is a valid method for estimating the 24 hour net acid excretion. Diet acid load may be important in many diseases associated with aging, such as loss of bone and muscle, and the development of kidney disease.

Study Overview

Status

Withdrawn

Conditions

Intervention / Treatment

Detailed Description

the primary outcome variable is morning urine pH and 24 hour urine net acid excretion

Study Type

Interventional

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • California
      • San Francisco, California, United States, 94143
        • UCSF

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 65 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • no medical or psychological problems
  • able to come to UCSF for study

Exclusion Criteria:

  • pregnant or trying to become pregnant
  • Hg < 10
  • abnormal screening labs
  • anyone unable to follow study directions

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Diagnostic
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: feeding a high acid diet x 24 hrs
2 diets, one low and one high net acid loads
Other: high or low acid diet
high or low acid diets
Active Comparator: low acid diet
Other: high or low acid diet
high or low acid diets

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
high acid diet
Time Frame: 6 months
correlation between first morning urine pH and 24 hour net acid excretion
6 months
low acid diet
Time Frame: 6 months
correlation between first morning urine pH and 24 hour net acid excretion
6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of California, San Francisco

Collaborators

optimal wellness labs

Investigators

  • Principal Investigator: lynda frassetto, md, University of California, San Francisco

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2015

Primary Completion (Actual)

June 1, 2015

Study Completion (Actual)

May 1, 2016

Study Registration Dates

First Submitted

April 15, 2014

First Submitted That Met QC Criteria

April 16, 2014

First Posted (Estimate)

April 17, 2014

Study Record Updates

Last Update Posted (Actual)

July 27, 2017

Last Update Submitted That Met QC Criteria

July 25, 2017

Last Verified

July 1, 2017

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • UPH&DNAE

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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