The National Myelodysplastic Syndromes (MDS) Study (MDS)

April 11, 2024 updated by: National Heart, Lung, and Blood Institute (NHLBI)

The National Myelodysplastic Syndromes Natural History Study

Multi-center study enrolling patients suspected or newly diagnosed with myelodysplastic syndromes (MDS), myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) overlap disorder, or idiopathic cytopenia of undetermined significance (ICUS). Participants will be followed long term. Clinical data, blood, and tissue samples will be collected to establish a biorepository to facilitate the study of the natural history of MDS.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

Multi-center, prospective cohort study enrolling patients from centers in the National Cancer Institute (NCI) National Clinical Trials Network (NCTN) and NCI Community Oncology Research Program (NCORP). The accrual period is 5+ years. After central pathology review of registered participants, approximately 2,000 cases of MDS or MDS/MPN overlap disorders, and 500 cases of ICUS will be identified for the longitudinal study cohort and up to 1000 cases will be identified for the cross-sectional cohort. No more than 3500 total participants will be registered. Participants in the longitudinal cohort may be followed for life.

The goal of the National MDS Study is to establish a publicly available resource to facilitate the study of MDS natural history. This will be accomplished through: 1) Creation of a multi-institutional, longitudinal collection of consistently processed and clinically well-annotated blood and tissue specimens collected prospectively from participants with MDS and participants with idiopathic cytopenia of undetermined significance (ICUS); and 2) Support for investigator-initiated studies of MDS that will have high-impact for MDS patients, including basic science, clinical, health outcomes and epidemiological research.

Study Type

Observational

Enrollment (Estimated)

3500

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • Israel
      • Jerusalem, Israel, 9103102
        • Recruiting
        • Shaare Zedek Medical Center
        • Contact:
        • Principal Investigator:
          • Jacob Michael Rowe, MD
  • United States
    • California
      • Anaheim, California, United States, 92806
        • Recruiting
        • Kaiser Permanente-Anaheim
        • Contact:
        • Principal Investigator:
          • Louis Fehrenbacher, MD
      • Baldwin Park, California, United States, 91706
        • Recruiting
        • Kaiser Permanente-Baldwin Park
        • Contact:
        • Principal Investigator:
          • Louis Fehrenbacher, MD
      • Bellflower, California, United States, 90706
        • Recruiting
        • Kaiser Permanente-Bellflower
        • Contact:
        • Principal Investigator:
          • Louis Fehrenbacher, MD
      • Fontana, California, United States, 92335
        • Recruiting
        • Kaiser Permanente-Fontana
        • Contact:
        • Principal Investigator:
          • Louis Fehrenbacher, MD
      • Harbor City, California, United States, 90710
        • Recruiting
        • Kaiser Permanente - South Bay
        • Contact:
        • Principal Investigator:
          • Louis Fehrenbacher, MD
      • Irvine, California, United States, 92618
        • Recruiting
        • Kaiser Permanente-Irvine
        • Contact:
        • Principal Investigator:
          • Louis Fehrenbacher, MD
      • Long Beach, California, United States, 90822
        • Recruiting
        • Tibor Rubin VA Medical Center
        • Principal Investigator:
          • Steve Lee
      • Los Angeles, California, United States, 90027
        • Recruiting
        • Kaiser Permanente Los Angeles Medical Center
        • Principal Investigator:
          • Louis Fehrenbacher, MD
        • Contact:
      • Los Angeles, California, United States, 90034
        • Recruiting
        • Kaiser Permanente-Cadillac
        • Contact:
        • Principal Investigator:
          • Louis Fehrenbacher, MD
      • Palo Alto, California, United States, 94304
        • Recruiting
        • VA Palo Alto Health Care System
      • Panorama City, California, United States, 91402
        • Recruiting
        • Kaiser Permanente - Panorama City
        • Principal Investigator:
          • Louis Fehrenbacher, MD
        • Contact:
      • Rancho Mirage, California, United States, 92270
        • Recruiting
        • Eisenhower Medical Center
        • Contact:
        • Principal Investigator:
          • Luke Dreisbach, MD
      • Riverside, California, United States, 92505
        • Recruiting
        • Kaiser Permanente-Riverside
        • Contact:
        • Principal Investigator:
          • Louis Fehrenbacher, MD
      • San Diego, California, United States, 92120
        • Recruiting
        • Kaiser Permanente-San Diego Zion
        • Contact:
        • Principal Investigator:
          • Louis Fehrenbacher, MD
      • San Francisco, California, United States, 94121
        • Recruiting
        • Veterans Affairs Medical Center - San Francisco
      • San Marcos, California, United States, 92078
        • Recruiting
        • Kaiser Permanente-San Marcos
        • Contact:
        • Principal Investigator:
          • Louis Fehrenbacher, MD
      • Woodland Hills, California, United States, 91367
        • Recruiting
        • Kaiser Permanente-Woodland Hills
        • Principal Investigator:
          • Louis Fehrenbacher, MD
        • Contact:
    • Colorado
      • Aurora, Colorado, United States, 80045
        • Recruiting
        • Rocky Mountain Regional VA Medical Center
    • Connecticut
      • New Haven, Connecticut, United States, 06520
        • Recruiting
        • Yale University
        • Contact:
        • Principal Investigator:
          • Steven Gore, MD
      • New Haven, Connecticut, United States, 06511
        • Recruiting
        • Smilow Cancer Center/Yale-New Haven Hospital
        • Contact:
        • Principal Investigator:
          • Steven Gore, MD
      • West Haven, Connecticut, United States, 06516
        • Recruiting
        • Veterans Affairs Connecticut Healthcare System-West Haven Campus
        • Contact:
        • Principal Investigator:
          • Michael Rose, MD
    • Delaware
      • Newark, Delaware, United States, 19713
        • Recruiting
        • Helen F Graham Cancer Center
        • Contact:
        • Principal Investigator:
          • Gregory Andrew Masters, MD
      • Newark, Delaware, United States, 19713
        • Recruiting
        • Medical Oncology Hematology Consultants PA
        • Contact:
        • Principal Investigator:
          • Gregory A Masters, MD
      • Newark, Delaware, United States, 19718
        • Recruiting
        • Christiana Care Health System-Christiana Hospital
        • Contact:
        • Principal Investigator:
          • Gregory Masters, MD
      • Newark, Delaware, United States, 19713
        • Terminated
        • Regional Hematology and Oncology PA
    • Florida
      • Jacksonville, Florida, United States, 32224
        • Recruiting
        • Mayo Clinic in Florida
        • Contact:
        • Principal Investigator:
          • Thomas Habermann, MD
      • Jacksonville, Florida, United States, 32207
        • Recruiting
        • Baptist MD Anderson Cancer Center
        • Contact:
        • Principal Investigator:
          • Edward Gorak, DO, MS, MBA
      • Lakeland, Florida, United States, 33805
        • Recruiting
        • Lakeland Regional Health Hollis Cancer Center
        • Principal Investigator:
          • Madhavi Venigalla, MD
        • Contact:
      • Tampa, Florida, United States, 33612
        • Recruiting
        • Moffitt Cancer Center
      • Vero Beach, Florida, United States, 32960
        • Terminated
        • Indian River Medical Center
    • Georgia
      • Atlanta, Georgia, United States, 30342
        • Recruiting
        • Northside Hospital
        • Contact:
        • Principal Investigator:
          • Amielia Zelnak, MD
      • Augusta, Georgia, United States, 30912
        • Recruiting
        • Augusta University Medical Center
        • Contact:
        • Principal Investigator:
          • Vamsi Kota, MD
      • Decatur, Georgia, United States, 30033
        • Recruiting
        • Atlanta VA Medical Center
        • Contact:
        • Principal Investigator:
          • Maria Jose Ribeiro, MD
      • Duluth, Georgia, United States, 30096
        • Recruiting
        • Northside Hospital - Duluth
        • Contact:
        • Principal Investigator:
          • Daniel P Barboriak, MD
      • Gainesville, Georgia, United States, 30501
        • Recruiting
        • Northeast Georgia Medical Center-Gainesville
        • Contact:
        • Principal Investigator:
          • Charles Nash, MD
      • Lawrenceville, Georgia, United States, 30046
        • Recruiting
        • Northside Hospital - Gwinnett
        • Contact:
        • Principal Investigator:
          • Aldemar Montero, MD
      • Savannah, Georgia, United States, 31405
        • Recruiting
        • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
        • Contact:
        • Principal Investigator:
          • Howard Zaren, MD, FACS
      • Snellville, Georgia, United States, 30078
        • Recruiting
        • Suburban Hematology Oncology Associates - Snellville
        • Contact:
        • Principal Investigator:
          • Daniel P Barboriak, MD
    • Hawaii
      • 'Aiea, Hawaii, United States, 96701
        • Recruiting
        • Pali Momi Medical Center
        • Contact:
        • Principal Investigator:
          • Jeffrey Berenberg, MD
      • 'Aiea, Hawaii, United States, 96701
        • Recruiting
        • Queen's Cancer Center - Pearlridge
        • Contact:
        • Principal Investigator:
          • Jeffrey L. Berenberg, MD
      • Honolulu, Hawaii, United States, 96826
        • Recruiting
        • Kapiolani Medical Center for Women and Children
        • Contact:
        • Principal Investigator:
          • Jeffrey L Berenberg, MD
      • Honolulu, Hawaii, United States, 96813
        • Recruiting
        • Queen's Medical Center
        • Principal Investigator:
          • Jeffrey L Berenberg, MD
        • Contact:
      • Honolulu, Hawaii, United States, 96813
        • Recruiting
        • Straub Clinic and Hospital
        • Principal Investigator:
          • Jeffrey Berenberg, MD
        • Contact:
      • Honolulu, Hawaii, United States, 96813
        • Recruiting
        • University of Hawaii Cancer Center
        • Principal Investigator:
          • Jeffrey L Berenberg, MD
        • Contact:
      • Honolulu, Hawaii, United States, 96817
        • Recruiting
        • Queen's Cancer Center - Kuakini
        • Principal Investigator:
          • Jeffrey L Berenberg, MD
        • Contact:
      • Honolulu, Hawaii, United States, 96813
        • Recruiting
        • Queen's Cancer Center - POB I
        • Contact:
        • Principal Investigator:
          • Jeffrey L Berenberg, MD
      • Honolulu, Hawaii, United States, 96817
        • Recruiting
        • Hawaii Cancer Care Inc-POB II
        • Principal Investigator:
          • Jeffrey L Berenberg, MD
        • Contact:
      • Honolulu, Hawaii, United States, 96817
        • Recruiting
        • OnCare Hawaii - Liliha
        • Principal Investigator:
          • Jeffrey L. Berenberg, MD
        • Contact:
    • Idaho
      • Coeur d'Alene, Idaho, United States, 83814
        • Recruiting
        • Kootenai Medical Center
        • Contact:
        • Principal Investigator:
          • Benjamin Marchello, MD
      • Post Falls, Idaho, United States, 83854
        • Recruiting
        • Kootenai Cancer Center
        • Contact:
        • Principal Investigator:
          • Benjamin Marchello, MD
      • Sandpoint, Idaho, United States, 83864
        • Recruiting
        • Kootenai Cancer Clinic
        • Contact:
        • Principal Investigator:
          • Benjamin Marchello, MD
    • Illinois
      • Bloomington, Illinois, United States, 61704
        • Recruiting
        • Illinois CancerCare - Bloomington
        • Contact:
        • Principal Investigator:
          • James Lloyd Wade, Md, FACP, FASCO
      • Carbondale, Illinois, United States, 62901
        • Recruiting
        • Memorial Hospital of Carbondale
        • Contact:
        • Principal Investigator:
          • James Lloyd Wade, MD
      • Carterville, Illinois, United States, 62918
        • Recruiting
        • SIH Cancer Institute
        • Contact:
        • Principal Investigator:
          • James Lloyd Wade, MD, FACP
      • Centralia, Illinois, United States, 62801
        • Recruiting
        • Centralia Oncology Clinic
        • Contact:
        • Principal Investigator:
          • James Lloyd Wade, MD
      • Danville, Illinois, United States, 61832
        • Recruiting
        • Carle on Vermilion
        • Principal Investigator:
          • Kendrith Rowland, MD
        • Contact:
      • Decatur, Illinois, United States, 62522
        • Recruiting
        • Decatur Memorial Hospital
        • Contact:
        • Principal Investigator:
          • James Lloyd Wade, MD
      • Decatur, Illinois, United States, 62568
        • Recruiting
        • Cancer Care Specialists of Central Illinois - Decatur
        • Contact:
        • Principal Investigator:
          • James Lloyd Wade, MD
      • Effingham, Illinois, United States, 62401
        • Recruiting
        • Carle Physician Group-Effingham
        • Principal Investigator:
          • Kendrith Rowland, MD
        • Contact:
      • Effingham, Illinois, United States, 62401
        • Recruiting
        • Crossroads Cancer Center
        • Contact:
        • Principal Investigator:
          • James Lloyd Wade, MD
      • Elk Grove Village, Illinois, United States, 60007
        • Recruiting
        • AMITA Health Alexian Brothers Medical Center
        • Contact:
        • Principal Investigator:
          • Bruce Bank, MD
      • Galesburg, Illinois, United States, 61401
        • Recruiting
        • Illinois CancerCare - Galesburg
        • Contact:
        • Principal Investigator:
          • James Lloyd Wade, Md, FACP, FASCO
      • Hinsdale, Illinois, United States, 60521
        • Recruiting
        • AMITA Health Cancer Institute and Outpatient Center
        • Contact:
        • Principal Investigator:
          • Donald Sweet, MD
      • Kankakee, Illinois, United States, 60901
        • Recruiting
        • Presence Saint Mary's Hospital
        • Contact:
        • Principal Investigator:
          • Sylvia Velinova Falls, MD
      • Mattoon, Illinois, United States, 61938
        • Recruiting
        • Carle Physician Group-Mattoon/Charleston
        • Principal Investigator:
          • Kendrith Rowland, MD
        • Contact:
      • O'Fallon, Illinois, United States, 62269
        • Recruiting
        • Cancer Care Specialists of O'Fallon
        • Contact:
        • Principal Investigator:
          • Bryan A Faller, MD
      • Peoria, Illinois, United States, 61615
        • Recruiting
        • Illinois CancerCare - Peoria
        • Contact:
        • Principal Investigator:
          • James Lloyd Wade, Md, FACP, FASCO
      • Urbana, Illinois, United States, 61801
        • Recruiting
        • Carle Cancer Center
        • Principal Investigator:
          • Kendrith Rowland, MD
        • Contact:
    • Iowa
      • Cedar Rapids, Iowa, United States, 52403
        • Recruiting
        • Mercy Hospital
        • Principal Investigator:
          • Deborah Wilbur, MD
        • Contact:
      • Cedar Rapids, Iowa, United States, 52403
        • Recruiting
        • Oncology Associates at Mercy Medical Center
        • Contact:
        • Principal Investigator:
          • Deborah W Wilbur, MD
      • Clive, Iowa, United States, 50325
        • Recruiting
        • Medical Oncology and Hematology Associates-West Des Moines
        • Contact:
        • Principal Investigator:
          • Mehmet Sitki Copur, MD
      • Clive, Iowa, United States, 50325
        • Recruiting
        • Mercy Cancer Center-West Lakes
        • Contact:
        • Principal Investigator:
          • Mehmet Sitki Copur, MD
      • Creston, Iowa, United States, 50801
        • Recruiting
        • Greater Regional Medical Center
        • Contact:
        • Principal Investigator:
          • Mehmet Sitki Copur, MD
      • Des Moines, Iowa, United States, 50314
        • Recruiting
        • Mercy Medical Center - Des Moines
        • Contact:
        • Principal Investigator:
          • Mehmet Sitki Copur, MD
      • Des Moines, Iowa, United States, 50309
        • Recruiting
        • Iowa Methodist Medical Center
        • Contact:
        • Principal Investigator:
          • Robert J Behrens, MD
      • Des Moines, Iowa, United States, 50314
        • Recruiting
        • Medical Oncology and Hematology Associates-Laurel
        • Contact:
        • Principal Investigator:
          • Mehmet Sitki Copur, MD
      • Des Moines, Iowa, United States, 50314
        • Recruiting
        • Medical Oncology and Hematology Associates-Des Moines
        • Contact:
        • Principal Investigator:
          • Robert J Behrens, MD
      • West Des Moines, Iowa, United States, 50266
        • Recruiting
        • Mercy Medical Center-West Lakes
        • Contact:
        • Principal Investigator:
          • Mehmet Sitki Copur, MD
    • Kansas
      • Chanute, Kansas, United States, 66720
      • Dodge City, Kansas, United States, 67801
        • Recruiting
        • Cancer Center of Kansas - Dodge City
        • Principal Investigator:
          • Shaker Dakhil, MD
        • Contact:
      • Fort Scott, Kansas, United States, 66701
        • Recruiting
        • Cancer Center of Kansas - Fort Scott
        • Principal Investigator:
          • Shaker Dakhil, MD
        • Contact:
      • Independence, Kansas, United States, 67301
        • Recruiting
        • Cancer Center of Kansas-Independence
        • Contact:
        • Principal Investigator:
          • Shaker R Dakhil, MD
      • Kingman, Kansas, United States, 67068
        • Recruiting
        • Cancer Center of Kansas-Kingman
        • Contact:
        • Principal Investigator:
          • Shaker R Dakhil, MD
      • Lawrence, Kansas, United States, 66044
      • Lenexa, Kansas, United States, 66219
        • Recruiting
        • Kansas Institute of Medicine Cancer and Blood Center
        • Contact:
        • Principal Investigator:
          • Rakesh Gaur, MD
      • Liberal, Kansas, United States, 67901
      • Newton, Kansas, United States, 67114
      • Parsons, Kansas, United States, 67357
      • Pratt, Kansas, United States, 67124
      • Salina, Kansas, United States, 67401
      • Wellington, Kansas, United States, 67152
        • Recruiting
        • Cancer Center of Kansas - Wellington
        • Principal Investigator:
          • Shaker Dakhil, MD
        • Contact:
      • Wichita, Kansas, United States, 67208
      • Wichita, Kansas, United States, 67208
        • Recruiting
        • Cancer Center of Kansas - Wichita Medical Arts Tower
        • Principal Investigator:
          • Shaker Dakhil, MD
        • Contact:
      • Wichita, Kansas, United States, 67208
      • Wichita, Kansas, United States, 67218
        • Recruiting
        • Ascension Via Christi Hospitals Wichita
        • Principal Investigator:
          • Shaker Dakhil, MD
        • Contact:
      • Winfield, Kansas, United States, 67156
    • Maine
      • Augusta, Maine, United States, 04330
        • Recruiting
        • Harold Alfond Center for Cancer Care
      • Belfast, Maine, United States, 04915
        • Recruiting
        • Waldo County General Hospital
      • Biddeford, Maine, United States, 04005
        • Recruiting
        • MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
      • Norway, Maine, United States, 04268
        • Recruiting
        • Stephens Memorial Hospital
      • Rockport, Maine, United States, 04856
        • Recruiting
        • Penobscot Bay Medical Center
      • Sanford, Maine, United States, 04073
        • Recruiting
        • MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
      • South Portland, Maine, United States, 01406
        • Recruiting
        • Maine Medical Partners-South Portland
      • York, Maine, United States, 03909
        • Recruiting
        • York Hospital
        • Principal Investigator:
          • Marilyn McLaughlin, MD
        • Contact:
    • Maryland
      • Baltimore, Maryland, United States, 21231
        • Recruiting
        • Johns Hopkins University/Sidney Kimmel Cancer Center
        • Principal Investigator:
          • Amy DeZern, MD
        • Contact:
      • Bel Air, Maryland, United States, 21014
        • Recruiting
        • UM Upper Chesapeake Medical Center
        • Contact:
        • Principal Investigator:
          • Ashkan Bahrani, MD
      • Bethesda, Maryland, United States, 20889
        • Recruiting
        • Walter Reed National Military Medical Center
        • Contact:
        • Principal Investigator:
          • Karen Zeman, MD
    • Massachusetts
      • Worcester, Massachusetts, United States, 01655
        • Recruiting
        • UMass Memorial Medical Center - University Campus
        • Contact:
        • Principal Investigator:
          • Joseph Leach, MD
    • Michigan
      • Ann Arbor, Michigan, United States, 48106
      • Brighton, Michigan, United States, 48114
      • Brighton, Michigan, United States, 48114
        • Recruiting
        • IHA Hematology Oncology Consultants-Brighton
        • Principal Investigator:
          • Philip Stella, MD
        • Contact:
      • Canton, Michigan, United States, 48188
      • Canton, Michigan, United States, 48188
        • Recruiting
        • IHA Hematology Oncology Consultants-Canton
        • Principal Investigator:
          • Philip Stella, MD
        • Contact:
      • Chelsea, Michigan, United States, 48118
      • Chelsea, Michigan, United States, 48118
        • Recruiting
        • IHA Hematology Oncology Consultants-Chelsea
        • Principal Investigator:
          • Philip Stella, MD
        • Contact:
      • Dearborn, Michigan, United States, 48124
      • East Lansing, Michigan, United States, 48824
        • Recruiting
        • Michigan State University Clinical Center
      • Grand Rapids, Michigan, United States, 49503
        • Recruiting
        • Spectrum Health at Butterworth Campus
        • Principal Investigator:
          • Kathleen Yost, MD
        • Contact:
      • Kalamazoo, Michigan, United States, 22787
        • Recruiting
        • West Michigan Cancer Center
        • Principal Investigator:
          • Kathleen Yost, MD
        • Contact:
      • Reed City, Michigan, United States, 49677
        • Recruiting
        • Spectrum Health Reed City Hospital
        • Principal Investigator:
          • Kathleen Yost, MD
        • Contact:
      • Royal Oak, Michigan, United States, 48073
        • Recruiting
        • William Beaumont Hospital-Royal Oak
        • Contact:
        • Principal Investigator:
          • John Robertson, MD
      • Saginaw, Michigan, United States, 48601
      • Southfield, Michigan, United States, 48075
        • Recruiting
        • Ascension Providence Hospitals - Southfield
      • Troy, Michigan, United States, 48073
        • Recruiting
        • William Beaumont Hospital - Troy
        • Contact:
        • Principal Investigator:
          • John Robertson, MD
      • Wyoming, Michigan, United States, 49519
        • Recruiting
        • Metro Health Hospital
        • Principal Investigator:
          • Kathleen Yost, MD
        • Contact:
      • Ypsilanti, Michigan, United States, 48197
        • Recruiting
        • IHA Hematology Oncology Consultants-Ann Arbor
        • Principal Investigator:
          • Philip Stella, MD
        • Contact:
    • Minnesota
      • Bemidji, Minnesota, United States, 56601
        • Recruiting
        • Sanford Joe Lueken Cancer Center
        • Contact:
        • Principal Investigator:
          • Preston D Steen, MD
      • Coon Rapids, Minnesota, United States, 55433
      • Duluth, Minnesota, United States, 55805
      • Duluth, Minnesota, United States, 55805
        • Recruiting
        • Essentia Health Saint Mary's Medical Center
        • Contact:
        • Principal Investigator:
          • Bret E.B. Friday, MD, PhD
      • Duluth, Minnesota, United States, 55805
      • Duluth, Minnesota, United States, 55802
        • Recruiting
        • Saint Luke's Hospital of Duluth
        • Contact:
        • Principal Investigator:
          • Basem Said Goueli, MD, PhD
      • Edina, Minnesota, United States, 55435
      • Fridley, Minnesota, United States, 55432
      • Minneapolis, Minnesota, United States, 55407
      • Minneapolis, Minnesota, United States, 55417
        • Recruiting
        • Minneapolis VA Medical Center
        • Contact:
        • Principal Investigator:
          • Sharon Luikart, MD
      • Saint Louis Park, Minnesota, United States, 55416
        • Recruiting
        • Park Nicollet Clinic - Saint Louis Park
        • Principal Investigator:
          • David King, MD
        • Contact:
      • Saint Paul, Minnesota, United States, 55102
      • Shakopee, Minnesota, United States, 55739
        • Recruiting
        • Saint Francis Regional Medical Center
        • Principal Investigator:
          • David King, MD
        • Contact:
    • Missouri
      • Cape Girardeau, Missouri, United States, 63703
        • Recruiting
        • Saint Francis Medical Center
        • Contact:
        • Principal Investigator:
          • James Lloyd Wade, MD
      • Jefferson City, Missouri, United States, 65109
        • Recruiting
        • Capital Region Southwest Campus
        • Principal Investigator:
          • James Wade, MD
        • Contact:
      • Kansas City, Missouri, United States, 64128
        • Recruiting
        • Kansas City Veterans Affairs Medical Center
        • Principal Investigator:
          • Suman Kambhampati, MD
        • Contact:
      • Rolla, Missouri, United States, 65401
        • Recruiting
        • Delbert Day Cancer Institute at PCRMC
        • Contact:
        • Principal Investigator:
          • James Carlson, MD
      • Rolla, Missouri, United States, 65401
        • Recruiting
        • Mercy Clinic - Rolla - Cancer and Hematology
        • Contact:
        • Principal Investigator:
          • James Lloyd Carlson, MD
      • Saint Joseph, Missouri, United States, 64506
        • Recruiting
        • Heartland Regional Medical Center
        • Contact:
        • Principal Investigator:
          • Rakesh Gaur, MD
      • Springfield, Missouri, United States, 65804
        • Recruiting
        • Mercy Hospital Springfield
        • Contact:
        • Principal Investigator:
          • James Lloyd Carlson, MD
      • Springfield, Missouri, United States, 65807
        • Recruiting
        • CoxHealth South Hospital
        • Contact:
        • Principal Investigator:
          • Carlson James Lloyd, MD
    • Montana
      • Anaconda, Montana, United States, 59711
        • Recruiting
        • Community Hospital of Anaconda
        • Contact:
        • Principal Investigator:
          • Benjamin T Marchello, MD
      • Bozeman, Montana, United States, 59715
        • Recruiting
        • Bozeman Deaconess Hospital
        • Contact:
        • Principal Investigator:
          • Benjamin Marchello, MD
      • Great Falls, Montana, United States, 59406
        • Recruiting
        • Benefis Healthcare-Sletten Cancer Institute
        • Contact:
        • Principal Investigator:
          • Benjamin Marchello, MD
    • Nebraska
      • Grand Island, Nebraska, United States, 68803
    • Nevada
      • Henderson, Nevada, United States, 89052
        • Recruiting
        • OptumCare Cancer Care at Seven Hills
        • Principal Investigator:
          • John Ellerton, MD
        • Contact:
      • Las Vegas, Nevada, United States, 89103
        • Recruiting
        • Hope Cancer Care of Nevada
        • Principal Investigator:
          • John Ellerton, MD
        • Contact:
      • Las Vegas, Nevada, United States, 89128
        • Recruiting
        • OptumCare Cancer Care at MountainView
        • Principal Investigator:
          • John Ellerton, MD
        • Contact:
      • Las Vegas, Nevada, United States, 89135
        • Recruiting
        • Alliance for Childhood Diseases/Cure 4 the Kids Foundation
        • Principal Investigator:
          • John Ellerton, MD
        • Contact:
      • Las Vegas, Nevada, United States, 89148
        • Recruiting
        • OptumCare Cancer Care at Fort Apache
        • Principal Investigator:
          • John Ellerton, MD
        • Contact:
      • Las Vegas, Nevada, United States, 89102
        • Recruiting
        • OptumCare Cancer Care at Oakey
        • Principal Investigator:
          • John Ellerton, MD
        • Contact:
        • Contact:
          • J
    • New Jersey
      • East Orange, New Jersey, United States, 07018-1095
        • Recruiting
        • Veterans Administration New Jersey Health Care System
        • Contact:
        • Principal Investigator:
          • Victor Chang, MD
      • Woodbury, New Jersey, United States, 08096
        • Recruiting
        • Inspira Medical Center Woodbury
        • Contact:
        • Principal Investigator:
          • Carl Minniti, MD
    • New Mexico
      • Albuquerque, New Mexico, United States, 87106
        • Recruiting
        • University of New Mexico Cancer Center
        • Contact:
        • Principal Investigator:
          • Steven Eberhardt, MD
      • Las Cruces, New Mexico, United States, 88011
        • Recruiting
        • Memorial Medical Center-Las Cruces
    • New York
      • Bronx, New York, United States, 10467
        • Recruiting
        • Montefiore Medical Center - Moses Campus
        • Contact:
        • Principal Investigator:
          • Joseph Sparano, MD
      • Bronx, New York, United States, 10468
        • Recruiting
        • James J Peters VA Medical Center
        • Principal Investigator:
          • Gary Schwartz, MD
        • Contact:
      • Bronx, New York, United States, 10461
        • Terminated
        • Montefiore Medical Center - Einstein Campus
      • Brooklyn, New York, United States, 11219
        • Recruiting
        • Maimonides Medical Center
      • Buffalo, New York, United States, 14263
        • Recruiting
        • Roswell Park Cancer Institute
        • Principal Investigator:
          • James Thompson, MD
        • Contact:
      • Elmira, New York, United States, 14905
        • Recruiting
        • Arnot Ogden Medical Center/Falck Cancer Center
        • Contact:
        • Principal Investigator:
          • William T Muuse, MD, FACP
      • Glens Falls, New York, United States, 12801
        • Recruiting
        • Glens Falls Hospital
      • Lake Success, New York, United States, 11042
        • Recruiting
        • Northwell Health/Center for Advanced Medicine
        • Contact:
        • Principal Investigator:
          • Vincent Vinciguerra, MD
      • Lake Success, New York, United States, 11042
        • Recruiting
        • North Shore University Hospital
        • Contact:
        • Principal Investigator:
          • Vincent Vinciguerra, MD
      • New Hyde Park, New York, United States, 11040
        • Recruiting
        • Long Island Jewish Medical Center
        • Contact:
        • Principal Investigator:
          • Vincent Vinciguerra, MD
      • Sleepy Hollow, New York, United States, 10591
        • Recruiting
        • Phelps Memorial Hospital Center
    • North Carolina
      • Asheville, North Carolina, United States, 28801
      • Durham, North Carolina, United States, 27705
        • Recruiting
        • Durham VA Medical Center
    • North Dakota
      • Bismarck, North Dakota, United States, 58501
      • Fargo, North Dakota, United States, 58122
        • Recruiting
        • Sanford Broadway Medical Center
        • Contact:
        • Principal Investigator:
          • Preston D Steen, MD
      • Fargo, North Dakota, United States, 58122
        • Recruiting
        • Sanford Roger Maris Cancer Center
        • Contact:
        • Principal Investigator:
          • Preston D Steen, MD
      • Fargo, North Dakota, United States, 58102
    • Ohio
      • Akron, Ohio, United States, 44307
        • Recruiting
        • Cleveland Clinic Akron General
        • Contact:
        • Principal Investigator:
          • Esther Hoogland Rehmus, MD
      • Cleveland, Ohio, United States, 44195
        • Recruiting
        • Cleveland Clinic Foundation
        • Principal Investigator:
          • Herbert Wiedemann, MD
      • Cleveland, Ohio, United States, 44109
        • Recruiting
        • MetroHealth Medical Center
        • Contact:
        • Principal Investigator:
          • Bruce J Averbook, MD
      • Fairview, Ohio, United States, 44111
        • Recruiting
        • Cleveland Clinic Cancer Center/Fairview Hospital
        • Principal Investigator:
          • Bruce J Averbook, MD
        • Contact:
      • Independence, Ohio, United States, 44131
        • Recruiting
        • Cleveland Clinic Cancer Center Independence
        • Principal Investigator:
          • Bruce J Averbook, MD
        • Contact:
      • Mansfield, Ohio, United States, 44906
        • Recruiting
        • Cleveland Clinic Cancer Center Mansfield
        • Principal Investigator:
          • Bruce J Averbook, MD
        • Contact:
      • Mayfield Heights, Ohio, United States, 44124
        • Recruiting
        • Hillcrest Hospital Cancer Center
        • Principal Investigator:
          • Bruce J Averbook, MD
        • Contact:
      • Sandusky, Ohio, United States, 44870
        • Recruiting
        • North Coast Cancer Care
        • Principal Investigator:
          • Bruce J Averbook, MD
        • Contact:
      • Wooster, Ohio, United States, 44691
        • Recruiting
        • Cleveland Clinic Wooster Family Health and Surgery Center
        • Principal Investigator:
          • Bruce J Averbook, MD
        • Contact:
    • Oklahoma
      • Lawton, Oklahoma, United States, 73505
        • Recruiting
        • Cancer Centers of Southwest Oklahoma Research
        • Contact:
        • Principal Investigator:
          • Adam Asch, MD
      • Oklahoma City, Oklahoma, United States, 73104
        • Recruiting
        • University of Oklahoma Health Sciences Center
        • Contact:
        • Principal Investigator:
          • Adam Asch, MD
      • Oklahoma City, Oklahoma, United States, 73120
        • Recruiting
        • Mercy Hospital Oklahoma City
        • Principal Investigator:
          • James Carlson, MD
        • Contact:
    • Oregon
      • Portland, Oregon, United States, 97239
        • Recruiting
        • Oregon Health & Science University
        • Contact:
        • Principal Investigator:
          • Kim-Hien Dao, Do, PhD
      • Portland, Oregon, United States, 97227
    • Pennsylvania
      • Allentown, Pennsylvania, United States, 18103
      • Bethlehem, Pennsylvania, United States, 18017
      • Danville, Pennsylvania, United States, 17821
        • Recruiting
        • Geisinger Medical Center
        • Contact:
        • Principal Investigator:
          • Joseph Joe Lukose Vadakara, MD
      • Easton, Pennsylvania, United States, 18042
      • Ephrata, Pennsylvania, United States, 17522
        • Recruiting
        • Ephrata Cancer Center
        • Contact:
        • Principal Investigator:
          • Amir Tabatabai, MD
      • Gettysburg, Pennsylvania, United States, 17325
        • Recruiting
        • Adams Cancer Center
        • Contact:
        • Principal Investigator:
          • Amir Tabatabai, MD
      • Hazleton, Pennsylvania, United States, 18201
        • Recruiting
        • Geisinger Medical Center - Cancer Center Hazleton
        • Contact:
        • Principal Investigator:
          • Joseph Joe Lukose Vadakara, MD
      • Lebanon, Pennsylvania, United States, 17042
        • Recruiting
        • Sechler Family Cancer Center
        • Contact:
        • Principal Investigator:
          • Amir Tabatabai, MD
      • Lewisburg, Pennsylvania, United States, 17837
        • Recruiting
        • Geisinger Medical Oncology - Lewisburg
        • Contact:
        • Principal Investigator:
          • Joseph Joe Lukose Vadakara, MD
      • Philadelphia, Pennsylvania, United States, 19104
        • Recruiting
        • University of Pennsylvania/Abramson Cancer Center
        • Contact:
        • Principal Investigator:
          • Selina Luger, MD
      • Phoenixville, Pennsylvania, United States, 19460
        • Recruiting
        • Phoenixville Hospital
        • Contact:
        • Principal Investigator:
          • Carl W Sharer, MD
      • Pottstown, Pennsylvania, United States, 19464
      • Pottsville, Pennsylvania, United States, 17901
        • Recruiting
        • Geisinger Cancer Services - Pottsville
        • Contact:
        • Principal Investigator:
          • Joseph Joe Lukose Vadakara, MD
      • Reading, Pennsylvania, United States, 19605
        • Recruiting
        • Penn State Health Saint Joseph Medical Center
        • Contact:
        • Principal Investigator:
          • Mark A Rovito, MD, FACS
      • Wilkes-Barre, Pennsylvania, United States, 18711
        • Recruiting
        • Geisinger Wyoming Valley/Henry Cancer Center
        • Contact:
        • Principal Investigator:
          • Joseph Joe Lukose Vadakara, MD
      • Williamsport, Pennsylvania, United States, 17701
      • York, Pennsylvania, United States, 17401
        • Recruiting
        • WellSpan Health-York Hospital
        • Contact:
        • Principal Investigator:
          • Amir Tabatabai, MD
    • South Carolina
      • Charleston, South Carolina, United States, 29401
        • Recruiting
        • Ralph H Johnson VA Medical Center
        • Contact:
        • Principal Investigator:
          • Rinah I Shopnick, DO
      • Easley, South Carolina, United States, 29640
        • Recruiting
        • Prisma Health Cancer Institute - Easley
        • Contact:
        • Principal Investigator:
          • Jeffrey K Giguere, MD
      • Greenville, South Carolina, United States, 29601
      • Greenville, South Carolina, United States, 29607
      • Greenville, South Carolina, United States, 29605
        • Recruiting
        • Prisma Health System Cancer Institute - Eastside
        • Contact:
        • Principal Investigator:
          • Jeffrey Giguere, MD
      • Greenville, South Carolina, United States, 29605
        • Recruiting
        • Prisma Health System Cancer Institute - Faris
        • Contact:
        • Principal Investigator:
          • Jeffrey Giguere, MD
      • Greenwood, South Carolina, United States, 29646
        • Recruiting
        • Self Regional Healthcare
        • Contact:
        • Principal Investigator:
          • Joanna Metzner-Sadurski, MD
      • Greer, South Carolina, United States, 29650
        • Recruiting
        • Prisma Health System Cancer Institute - Greer
        • Contact:
        • Principal Investigator:
          • Jeffrey Giguere, MD
      • Reidville, South Carolina, United States, 29605
        • Recruiting
        • Prisma Health System Cancer Institute - Butternut
        • Contact:
        • Principal Investigator:
          • Jeffrey K Giguere, MD
      • Seneca, South Carolina, United States, 29672
        • Recruiting
        • Prisma Health System Cancer Institute - Seneca
        • Contact:
        • Principal Investigator:
          • Jeffrey Giguere, MD
      • Spartanburg, South Carolina, United States, 29303
      • Spartanburg, South Carolina, United States, 29307
        • Recruiting
        • Prisma Health System Cancer Institute - Spartanburg
        • Contact:
        • Principal Investigator:
          • Jeffrey Giguere, MD
    • South Dakota
      • Aberdeen, South Dakota, United States, 57401
        • Recruiting
        • Avera Cancer Institute-Aberdeen
        • Contact:
        • Principal Investigator:
          • Vinod Parameswaran, MD
      • Rapid City, South Dakota, United States, 57701
        • Recruiting
        • Monument Health Rapid City Hospital
        • Contact:
        • Principal Investigator:
          • Preston D Steen, MD
      • Sioux Falls, South Dakota, United States, 57104
        • Recruiting
        • Sanford Cancer Center Oncology Clinic
        • Principal Investigator:
          • Preston Steen, MD
        • Contact:
      • Sioux Falls, South Dakota, United States, 57105
        • Recruiting
        • Avera Cancer Institute
        • Contact:
        • Principal Investigator:
          • Vinod Parameswaran, MD
      • Sioux Falls, South Dakota, United States, 57117
        • Recruiting
        • Sanford USD Medical Center - Sioux Falls
        • Principal Investigator:
          • Preston Steen, MD
        • Contact:
    • Tennessee
      • Memphis, Tennessee, United States, 38120
        • Recruiting
        • Baptist Memorial Hospital and Cancer Center-Memphis
        • Contact:
        • Principal Investigator:
          • Salil Goorha, MD
      • Nashville, Tennessee, United States, 37208
        • Recruiting
        • Meharry Medical College
        • Contact:
        • Principal Investigator:
          • Salil Goorha, MD
    • Texas
      • Austin, Texas, United States, 78701
        • Recruiting
        • Dell Seton Medical Center at The University of Texas
        • Contact:
        • Principal Investigator:
          • Alka Mallik, MD
      • Dallas, Texas, United States, 75390
        • Recruiting
        • UT Southwestern/Simmons Cancer Center-Dallas
        • Principal Investigator:
          • David Gerber, MD
        • Contact:
      • Richardson, Texas, United States, 75080
        • Recruiting
        • UT Southwestern Clinical Center at Richardson/Plano
        • Contact:
        • Principal Investigator:
          • Suzanne Marie Cole, MD
      • San Antonio, Texas, United States, 78229
        • Recruiting
        • University of Texas Health Science Center at San Antonio
        • Contact:
        • Principal Investigator:
          • Anand Karnad, MD
    • Virginia
      • Fishersville, Virginia, United States, 22939
        • Recruiting
        • Augusta Health Center for Cancer and Blood Disorders
        • Contact:
        • Principal Investigator:
          • Kelvin Raybon, MD
    • Washington
      • Auburn, Washington, United States, 98001
        • Recruiting
        • MultiCare Auburn Medical Center
        • Contact:
        • Principal Investigator:
          • John A Keech, DO
      • Bremerton, Washington, United States, 98310
        • Recruiting
        • Harrison HealthPartners Hematology and Oncology-Bremerton
        • Principal Investigator:
          • Mehmet Sitki Copur, MD
        • Contact:
      • Bremerton, Washington, United States, 98310
      • Gig Harbor, Washington, United States, 98335
        • Recruiting
        • MultiCare Gig Harbor Medical Park
        • Contact:
        • Principal Investigator:
          • John A Keech, DO
      • Poulsbo, Washington, United States, 98370
        • Recruiting
        • Harrison HealthPartners Hematology and Oncology-Poulsbo
        • Principal Investigator:
          • Mehmet Sitki Copur, MD
        • Contact:
      • Puyallup, Washington, United States, 98372
        • Recruiting
        • MultiCare Good Samaritan Hospital
        • Contact:
        • Principal Investigator:
          • John A Keech, DO
      • Seattle, Washington, United States, 98109
        • Recruiting
        • Fred Hutchinson Cancer Research Center
        • Contact:
        • Principal Investigator:
          • Frederick Applebaum, MD
      • Seattle, Washington, United States, 98109
        • Recruiting
        • Seattle Cancer Care Alliance
        • Contact:
        • Principal Investigator:
          • Frederick Applebaum, MD
      • Seattle, Washington, United States, 98115
        • Recruiting
        • University of Washington Medical Center
        • Contact:
        • Principal Investigator:
          • Frederick Applebaum, MD
      • Tacoma, Washington, United States, 98405
        • Recruiting
        • MultiCare Tacoma General Hospital
        • Contact:
        • Principal Investigator:
          • John A Keech, DO
    • West Virginia
      • Charleston, West Virginia, United States, 25304
        • Recruiting
        • West Virginia University Charleston Division
        • Contact:
        • Principal Investigator:
          • Steven James Jubelirer, MD
    • Wisconsin
      • Brookfield, Wisconsin, United States, 53045
        • Recruiting
        • Ascension Southeast Wisconsin Hospital-Elmbrook Campus
      • Burlington, Wisconsin, United States, 53105
        • Recruiting
        • Aurora Cancer Care-Southern Lakes VLCC
        • Contact:
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
      • Eau Claire, Wisconsin, United States, 54701
      • Fontana, Wisconsin, United States, 54937
        • Recruiting
        • Aurora Health Center-Fond du Lac
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
        • Contact:
      • Franklin, Wisconsin, United States, 53132
        • Recruiting
        • Ascension Saint Francis-Reiman Cancer Center
      • Germantown, Wisconsin, United States, 53022
        • Recruiting
        • Aurora Health Care Germantown Health Center
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
        • Contact:
      • Grafton, Wisconsin, United States, 53024
        • Recruiting
        • Aurora Cancer Care-Grafton
        • Contact:
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
      • Green Bay, Wisconsin, United States, 54311
        • Recruiting
        • Aurora BayCare Medical Center
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
        • Contact:
      • Green Bay, Wisconsin, United States, 54301
        • Recruiting
        • Saint Vincent Hospital Cancer Center Green Bay
        • Contact:
        • Principal Investigator:
          • Brian L Burnette, MD
      • Green Bay, Wisconsin, United States, 53715
        • Recruiting
        • Saint Vincent Hospital Cancer Center at Saint Mary's
        • Contact:
        • Principal Investigator:
          • Brian L Burnette, MD
      • Kenosha, Wisconsin, United States, 53412
        • Recruiting
        • Aurora Cancer Care-Kenosha South
        • Contact:
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
      • La Crosse, Wisconsin, United States, 54601
        • Recruiting
        • Gundersen Lutheran Medical Center
        • Principal Investigator:
          • Brian Burnette, MD
        • Contact:
      • La Crosse, Wisconsin, United States, 54601
        • Recruiting
        • Mayo Clinic Health System-Franciscan Healthcare
        • Principal Investigator:
          • Thomas Habermann, MD
        • Contact:
      • Madison, Wisconsin, United States, 53705
        • Recruiting
        • William S Middleton VA Medical Center
        • Contact:
        • Principal Investigator:
          • Mark Richard Albertini, MD
      • Madison, Wisconsin, United States, 53792
        • Recruiting
        • University of Wisconsin Hospital and Clinics
        • Contact:
        • Principal Investigator:
          • Preston Steen, MD
      • Manitowoc, Wisconsin, United States, 54220
        • Recruiting
        • Holy Family Memorial Hospital
        • Contact:
        • Principal Investigator:
          • Brian L. Burnette, MD
      • Marinette, Wisconsin, United States, 54143
        • Recruiting
        • Aurora Bay Area Medical Group-Marinette
        • Contact:
        • Principal Investigator:
          • Thomas Saphner, MD
      • Marinette, Wisconsin, United States, 54143
        • Recruiting
        • Vince Lombardi Cancer Clinic-Marinette
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
        • Contact:
      • Marshfield, Wisconsin, United States, 54449
        • Recruiting
        • Marshfield Medical Center - Marshfield
        • Contact:
        • Principal Investigator:
          • Brian Leslie Burnette, MD
      • Milwaukee, Wisconsin, United States, 53215
        • Recruiting
        • Aurora Saint Luke's Medical Center
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
        • Contact:
      • Milwaukee, Wisconsin, United States, 53233
        • Recruiting
        • Aurora Sinai Medical Center
        • Contact:
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
      • Milwaukee, Wisconsin, United States, 53226
        • Recruiting
        • Aurora Cancer Care-Milwaukee
        • Contact:
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
      • Minocqua, Wisconsin, United States, 54548
        • Recruiting
        • Marshfield Clinic-Minocqua Center
        • Principal Investigator:
          • Brian Leslie Burnette, MD
        • Contact:
      • Oshkosh, Wisconsin, United States, 54904
        • Recruiting
        • Vince Lombardi Cancer Clinic - Oshkosh
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
        • Contact:
      • Oshkosh, Wisconsin, United States, 54904
        • Recruiting
        • Ascension Mercy Hospital
      • Racine, Wisconsin, United States, 53406
        • Recruiting
        • Aurora Cancer Care-Racine
        • Contact:
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
      • Racine, Wisconsin, United States, 53405
        • Recruiting
        • Ascension All Saints Hospital
      • Rice Lake, Wisconsin, United States, 54868
        • Recruiting
        • Marshfield Medical Center - Rice Lake
        • Contact:
        • Principal Investigator:
          • Brian Leslie Burnette, MD
      • Sheboygan, Wisconsin, United States, 53081
        • Recruiting
        • Vince Lombardi Cancer Clinic-Sheboygan
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
        • Contact:
      • Stevens Point, Wisconsin, United States, 54482
      • Summit, Wisconsin, United States, 53066
        • Recruiting
        • Aurora Medical Center in Summit
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
        • Contact:
      • Two Rivers, Wisconsin, United States, 54241
        • Recruiting
        • Vince Lombardi Cancer Clinic-Two Rivers
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
        • Contact:
      • Wauwatosa, Wisconsin, United States, 53226
        • Recruiting
        • Aurora Cancer Care-Milwaukee West
        • Contact:
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
      • Wauwatosa, Wisconsin, United States, 53226
        • Recruiting
        • Ascension Medical Group Southeast Wisconsin-Mayfair Road
      • West Allis, Wisconsin, United States, 53227
        • Recruiting
        • Aurora West Allis Medical Center
        • Contact:
        • Principal Investigator:
          • Thomas Saphner, MD, FACP
      • Weston, Wisconsin, United States, 54476
        • Recruiting
        • Marshfield Clinic-Weston Center
        • Contact:
        • Principal Investigator:
          • Brian Leslie Burnette, MD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

16 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Patients with suspected MDS or MDS/MPN overlap disorder who are undergoing diagnostic workup and bone marrow assessments, and patients diagnosed with MDS within 6-months of enrollment and undergoing clinical evaluation and bone marrow assessments to confirm MDS or evaluate disease status

Description

Inclusion Criteria:

  • Suspected (e.g., persistent unexplained cytopenia, circulating peripheral blasts etc.) MDS or MDS/MPN overlap disorders and undergoing diagnostic work-up with planned bone marrow assessments, or diagnosed with de novo or therapy-related MDS within 12 months of enrollment per the World Health Organization (WHO) criteria1 and undergoing clinical evaluation and planned bone marrow assessments to confirm MDS or to evaluate disease status
  • Bone marrow aspirate expected to be performed within 1 week of registration, and in all cases must be performed no later than 4 weeks after enrollment
  • Age 18 or older
  • If anemic without prior MDS diagnosis, B12 level, serum folate, mean corpuscular volume (MCV), red cell distribution width (RDW), ferritin, and iron studies (Iron, total iron-binding capacity (TIBC) test, and percent saturation) must be performed within prior 6 months.

Exclusion Criteria:

  • Prior treatment for MDS at entry and through the time of the entry bone marrow aspirate
  • Treatment with hematopoietic growth factors in prior 6 months
  • Diagnosis of a solid tumor or hematologic malignancy within two years prior to enrollment except for in situ cancer of the skin (basal or squamous cell), cervix, bladder, breast, or prostate
  • Treatment with radiation therapy in the two years prior to registration
  • Non-hormonal treatment for malignancy within the two years prior to registration
  • Established hereditary bone marrow failure syndrome
  • Known primary diagnosis of aplastic anemia, classical paroxysmal nocturnal hemoglobinuria, amegakaryocytic thrombocytopenic purpura, or large granular lymphocyte leukemia
  • Enrolled in the Connect® MDS/AML Disease Registry (NCT01688011)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Prospective

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Longitudinal
Participants with MDS, MDS/MPN overlap disorder, AML <30% blasts without core binding factor or acute promyelocytic leukemia, ICUS, or at risk based on select karyotypic or genetic abnormalities
Other: Therapeutic
Observational Study
Cross-sectional
Participants who do not have MDS, MDS/MPN overlap disorder, or ICUS and have the baseline visit only
Other: Therapeutic
Observational Study

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Number of patients dying
Time Frame: Through study completion, an average of 3 years
Deaths will be reported on study case report forms
Through study completion, an average of 3 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Number of participants progressing to Acute Myeloid Leukemia (AML)
Time Frame: Through study completion, an average of 3 years
Progression to AML will be reported on study case report forms
Through study completion, an average of 3 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Collaborators

National Cancer Institute (NCI)

Investigators

  • Study Chair: Mikkael Sekeres, MD, MS, University of Miami
  • Study Chair: Amy DeZern, MD, MHS, Johns Hopkins University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 13, 2016

Primary Completion (Estimated)

March 31, 2025

Study Completion (Estimated)

March 31, 2025

Study Registration Dates

First Submitted

May 2, 2016

First Submitted That Met QC Criteria

May 16, 2016

First Posted (Estimated)

May 17, 2016

Study Record Updates

Last Update Posted (Actual)

April 12, 2024

Last Update Submitted That Met QC Criteria

April 11, 2024

Last Verified

April 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • NHLBI-MDS

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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