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National Myelodysplastic Syndromes (MDS) undersøgelse (MDS)

30. januar 2026 opdateret af: National Heart, Lung, and Blood Institute (NHLBI)

National Myelodysplastic Syndromes Natural History Study

Multicenterundersøgelse, der indskriver patienter, der mistænkes for eller er nydiagnosticeret med myelodysplastiske syndromer (MDS), myelodysplastiske syndromer/myeloproliferative neoplasmer (MDS/MPN) overlapningslidelse eller idiopatisk cytopeni af ubestemt betydning (ICUS). Deltagerne vil blive fulgt i længere tid. Kliniske data, blod- og vævsprøver vil blive indsamlet for at etablere et biodepot for at lette studiet af MDS's naturlige historie.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Multicenter, prospektiv kohorteundersøgelse, der indskriver patienter fra centre i National Cancer Institute (NCI) National Clinical Trials Network (NCTN) og NCI Community Oncology Research Program (NCORP). Optjeningsperioden er 5+ år. Efter central patologigennemgang af registrerede deltagere vil ca. 2.000 tilfælde af MDS eller MDS/MPN overlapningslidelser og 500 tilfælde af ICUS blive identificeret for den longitudinelle undersøgelseskohorte, og op til 1000 tilfælde vil blive identificeret for tværsnitskohorten. Der vil ikke blive tilmeldt mere end 3500 deltagere i alt. Deltagere i den langsgående kohorte kan følges hele livet.

Målet med den nationale MDS-undersøgelse er at etablere en offentligt tilgængelig ressource for at lette studiet af MDS naturhistorie. Dette vil blive opnået gennem: 1) Oprettelse af en multi-institutionel, longitudinel samling af konsekvent behandlede og klinisk velannoterede blod- og vævsprøver indsamlet prospektivt fra deltagere med MDS og deltagere med idiopatisk cytopeni af ubestemt betydning (ICUS); og 2) Støtte til investigator-initierede undersøgelser af MDS, som vil have stor indvirkning på MDS-patienter, herunder grundlæggende videnskab, kliniske, sundhedsmæssige resultater og epidemiologisk forskning.

Undersøgelsestype

Observationel

Tilmelding (Faktiske)

2115

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Forenede Stater
    • California
      • Anaheim, California, Forenede Stater, 92806
        • Kaiser Permanente-Anaheim
      • Baldwin Park, California, Forenede Stater, 91706
        • Kaiser Permanente-Baldwin Park
      • Bellflower, California, Forenede Stater, 90706
        • Kaiser Permanente-Bellflower
      • Fontana, California, Forenede Stater, 92335
        • Kaiser Permanente-Fontana
      • Harbor City, California, Forenede Stater, 90710
        • Kaiser Permanente - South Bay
      • Irvine, California, Forenede Stater, 92618
        • Kaiser Permanente-Irvine
      • Long Beach, California, Forenede Stater, 90822
        • Tibor Rubin VA Medical Center
      • Los Angeles, California, Forenede Stater, 90027
        • Kaiser Permanente Los Angeles Medical Center
      • Los Angeles, California, Forenede Stater, 90034
        • Kaiser Permanente-Cadillac
      • Palo Alto, California, Forenede Stater, 94304
        • VA Palo Alto Health Care System
      • Panorama City, California, Forenede Stater, 91402
        • Kaiser Permanente - Panorama City
      • Rancho Mirage, California, Forenede Stater, 92270
        • Eisenhower Medical Center
      • Riverside, California, Forenede Stater, 92505
        • Kaiser Permanente-Riverside
      • San Diego, California, Forenede Stater, 92120
        • Kaiser Permanente-San Diego Zion
      • San Francisco, California, Forenede Stater, 94121
        • Veterans Affairs Medical Center - San Francisco
      • San Marcos, California, Forenede Stater, 92078
        • Kaiser Permanente-San Marcos
      • Woodland Hills, California, Forenede Stater, 91367
        • Kaiser Permanente-Woodland Hills
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80045
        • Rocky Mountain Regional VA Medical Center
    • Connecticut
      • New Haven, Connecticut, Forenede Stater, 06520
        • Yale University
      • New Haven, Connecticut, Forenede Stater, 06511
        • Smilow Cancer Center/Yale-New Haven Hospital
      • West Haven, Connecticut, Forenede Stater, 06516
        • Veterans Affairs Connecticut Healthcare System-West Haven Campus
    • Delaware
      • Newark, Delaware, Forenede Stater, 19713
        • Helen F Graham Cancer Center
      • Newark, Delaware, Forenede Stater, 19713
        • Medical Oncology Hematology Consultants PA
      • Newark, Delaware, Forenede Stater, 19718
        • Christiana Care Health System-Christiana Hospital
      • Newark, Delaware, Forenede Stater, 19713
        • Regional Hematology and Oncology PA
    • Florida
      • Jacksonville, Florida, Forenede Stater, 32207
        • Baptist MD Anderson Cancer Center
      • Jacksonville, Florida, Forenede Stater, 32224
        • Mayo Clinic in Florida
      • Lakeland, Florida, Forenede Stater, 33805
        • Lakeland Regional Health Hollis Cancer Center
      • Tampa, Florida, Forenede Stater, 33612
        • Moffitt Cancer Center
      • Vero Beach, Florida, Forenede Stater, 32960
        • Indian River Medical Center
    • Georgia
      • Atlanta, Georgia, Forenede Stater, 30342
        • Northside Hospital
      • Augusta, Georgia, Forenede Stater, 30912
        • Augusta University Medical Center
      • Decatur, Georgia, Forenede Stater, 30033
        • Atlanta VA Medical Center
      • Duluth, Georgia, Forenede Stater, 30096
        • Northside Hospital - Duluth
      • Gainesville, Georgia, Forenede Stater, 30501
        • Northeast Georgia Medical Center-Gainesville
      • Lawrenceville, Georgia, Forenede Stater, 30046
        • Northside Hospital - Gwinnett
      • Savannah, Georgia, Forenede Stater, 31405
        • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
      • Snellville, Georgia, Forenede Stater, 30078
        • Suburban Hematology Oncology Associates - Snellville
    • Hawaii
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Queen's Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Straub Clinic and Hospital
      • Honolulu, Hawaii, Forenede Stater, 96813
        • University of Hawaii Cancer Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Queen's Cancer Center - Kuakini
      • Honolulu, Hawaii, Forenede Stater, 96826
        • Kapiolani Medical Center for Women and Children
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Queen's Cancer Center - POB I
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Hawaii Cancer Care Inc-POB II
      • Honolulu, Hawaii, Forenede Stater, 96817
        • OnCare Hawaii - Liliha
      • ‘Aiea, Hawaii, Forenede Stater, 96701
        • Pali Momi Medical Center
      • ‘Aiea, Hawaii, Forenede Stater, 96701
        • Queen's Cancer Center - Pearlridge
    • Idaho
      • Coeur d'Alene, Idaho, Forenede Stater, 83814
        • Kootenai Medical Center
      • Post Falls, Idaho, Forenede Stater, 83854
        • Kootenai Cancer Center
      • Sandpoint, Idaho, Forenede Stater, 83864
        • Kootenai Cancer Clinic
    • Illinois
      • Bloomington, Illinois, Forenede Stater, 61704
        • Illinois CancerCare - Bloomington
      • Carbondale, Illinois, Forenede Stater, 62901
        • Memorial Hospital of Carbondale
      • Carterville, Illinois, Forenede Stater, 62918
        • SIH Cancer Institute
      • Centralia, Illinois, Forenede Stater, 62801
        • Centralia Oncology Clinic
      • Danville, Illinois, Forenede Stater, 61832
        • Carle on Vermilion
      • Decatur, Illinois, Forenede Stater, 62522
        • Decatur Memorial Hospital
      • Decatur, Illinois, Forenede Stater, 62568
        • Cancer Care Specialists of Central Illinois - Decatur
      • Effingham, Illinois, Forenede Stater, 62401
        • Crossroads Cancer Center
      • Effingham, Illinois, Forenede Stater, 62401
        • Carle Physician Group-Effingham
      • Elk Grove Village, Illinois, Forenede Stater, 60007
        • AMITA Health Alexian Brothers Medical Center
      • Galesburg, Illinois, Forenede Stater, 61401
        • Illinois CancerCare - Galesburg
      • Hinsdale, Illinois, Forenede Stater, 60521
        • AMITA Health Cancer Institute and Outpatient Center
      • Kankakee, Illinois, Forenede Stater, 60901
        • Presence Saint Mary's Hospital
      • Mattoon, Illinois, Forenede Stater, 61938
        • Carle Physician Group-Mattoon/Charleston
      • O'Fallon, Illinois, Forenede Stater, 62269
        • Cancer Care Specialists of O'Fallon
      • Peoria, Illinois, Forenede Stater, 61615
        • Illinois CancerCare - Peoria
      • Urbana, Illinois, Forenede Stater, 61801
        • Carle Cancer Center
    • Iowa
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Mercy Hospital
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Oncology Associates at Mercy Medical Center
      • Clive, Iowa, Forenede Stater, 50325
        • Mercy Cancer Center-West Lakes
      • Clive, Iowa, Forenede Stater, 50325
        • Medical Oncology and Hematology Associates-West Des Moines
      • Creston, Iowa, Forenede Stater, 50801
        • Greater Regional Medical Center
      • Des Moines, Iowa, Forenede Stater, 50309
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, Forenede Stater, 50314
        • Mercy Medical Center - Des Moines
      • Des Moines, Iowa, Forenede Stater, 50314
        • Medical Oncology and Hematology Associates-Laurel
      • Des Moines, Iowa, Forenede Stater, 50314
        • Medical Oncology and Hematology Associates-Des Moines
      • West Des Moines, Iowa, Forenede Stater, 50266
        • Mercy Medical Center-West Lakes
    • Kansas
      • Chanute, Kansas, Forenede Stater, 66720
        • Cancer Center of Kansas - Chanute
      • Dodge City, Kansas, Forenede Stater, 67801
        • Cancer Center of Kansas - Dodge City
      • Fort Scott, Kansas, Forenede Stater, 66701
        • Cancer Center of Kansas - Fort Scott
      • Independence, Kansas, Forenede Stater, 67301
        • Cancer Center of Kansas-Independence
      • Kingman, Kansas, Forenede Stater, 67068
        • Cancer Center of Kansas-Kingman
      • Lawrence, Kansas, Forenede Stater, 66044
        • Lawrence Memorial Hospital
      • Lenexa, Kansas, Forenede Stater, 66219
        • Kansas Institute of Medicine Cancer and Blood Center
      • Liberal, Kansas, Forenede Stater, 67901
        • Cancer Center of Kansas - Liberal
      • Newton, Kansas, Forenede Stater, 67114
        • Cancer Center of Kansas - Newton
      • Parsons, Kansas, Forenede Stater, 67357
        • Cancer Center of Kansas - Parsons
      • Pratt, Kansas, Forenede Stater, 67124
        • Cancer Center of Kansas - Pratt
      • Salina, Kansas, Forenede Stater, 67401
        • Cancer Center of Kansas - Salina
      • Wellington, Kansas, Forenede Stater, 67152
        • Cancer Center of Kansas - Wellington
      • Wichita, Kansas, Forenede Stater, 67208
        • Associates In Womens Health
      • Wichita, Kansas, Forenede Stater, 67208
        • Cancer Center of Kansas - Wichita Medical Arts Tower
      • Wichita, Kansas, Forenede Stater, 67208
        • Cancer Center of Kansas - Wichita
      • Wichita, Kansas, Forenede Stater, 67218
        • Ascension Via Christi Hospitals Wichita
      • Winfield, Kansas, Forenede Stater, 67156
        • Cancer Center of Kansas - Winfield
    • Maine
      • Augusta, Maine, Forenede Stater, 04330
        • Harold Alfond Center for Cancer Care
      • Belfast, Maine, Forenede Stater, 04915
        • Waldo County General Hospital
      • Biddeford, Maine, Forenede Stater, 04005
        • MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
      • Norway, Maine, Forenede Stater, 04268
        • Stephens Memorial Hospital
      • Rockport, Maine, Forenede Stater, 04856
        • Penobscot Bay Medical Center
      • Sanford, Maine, Forenede Stater, 04073
        • MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
      • South Portland, Maine, Forenede Stater, 01406
        • Maine Medical Partners-South Portland
      • York Village, Maine, Forenede Stater, 03909
        • York Hospital
    • Maryland
      • Baltimore, Maryland, Forenede Stater, 21231
        • Johns Hopkins University/Sidney Kimmel Cancer Center
      • Bel Air, Maryland, Forenede Stater, 21014
        • UM Upper Chesapeake Medical Center
      • Bethesda, Maryland, Forenede Stater, 20889
        • Walter Reed National Military Medical Center
    • Massachusetts
      • Worcester, Massachusetts, Forenede Stater, 01655
        • UMass Memorial Medical Center - University Campus
    • Michigan
      • Ann Arbor, Michigan, Forenede Stater, 48106
        • Saint Joseph Mercy Hospital
      • Brighton, Michigan, Forenede Stater, 48114
        • Saint Joseph Mercy Brighton
      • Brighton, Michigan, Forenede Stater, 48114
        • IHA Hematology Oncology Consultants-Brighton
      • Canton, Michigan, Forenede Stater, 48188
        • Saint Joseph Mercy Canton
      • Canton, Michigan, Forenede Stater, 48188
        • IHA Hematology Oncology Consultants-Canton
      • Chelsea, Michigan, Forenede Stater, 48118
        • Saint Joseph Mercy Chelsea
      • Chelsea, Michigan, Forenede Stater, 48118
        • IHA Hematology Oncology Consultants-Chelsea
      • Dearborn, Michigan, Forenede Stater, 48124
        • Beaumont Hospital - Dearborn
      • East Lansing, Michigan, Forenede Stater, 48824
        • Michigan State University Clinical Center
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Spectrum Health at Butterworth Campus
      • Kalamazoo, Michigan, Forenede Stater, 22787
        • West Michigan Cancer Center
      • Reed City, Michigan, Forenede Stater, 49677
        • Spectrum Health Reed City Hospital
      • Royal Oak, Michigan, Forenede Stater, 48073
        • William Beaumont Hospital-Royal Oak
      • Saginaw, Michigan, Forenede Stater, 48601
        • Ascension Saint Mary's Hospital
      • Southfield, Michigan, Forenede Stater, 48075
        • Ascension Providence Hospitals - Southfield
      • Troy, Michigan, Forenede Stater, 48073
        • William Beaumont Hospital - Troy
      • Wyoming, Michigan, Forenede Stater, 49519
        • Metro Health Hospital
      • Ypsilanti, Michigan, Forenede Stater, 48197
        • IHA Hematology Oncology Consultants-Ann Arbor
    • Minnesota
      • Bemidji, Minnesota, Forenede Stater, 56601
        • Sanford Joe Lueken Cancer Center
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Mercy Hospital
      • Duluth, Minnesota, Forenede Stater, 55805
        • Essentia Health Cancer Center
      • Duluth, Minnesota, Forenede Stater, 55805
        • Essentia Health Saint Mary's Medical Center
      • Duluth, Minnesota, Forenede Stater, 55805
        • Miller-Dwan Hospital
      • Duluth, Minnesota, Forenede Stater, 55802
        • Saint Luke's Hospital of Duluth
      • Edina, Minnesota, Forenede Stater, 55435
        • Fairview Southdale Hospital
      • Fridley, Minnesota, Forenede Stater, 55432
        • Unity Hospital
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, Forenede Stater, 55417
        • Minneapolis VA Medical Center
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • United Hospital
      • Shakopee, Minnesota, Forenede Stater, 55739
        • Saint Francis Regional Medical Center
    • Missouri
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Saint Francis Medical Center
      • Jefferson City, Missouri, Forenede Stater, 65109
        • Capital Region Southwest Campus
      • Kansas City, Missouri, Forenede Stater, 64128
        • Kansas City Veterans Affairs Medical Center
      • Rolla, Missouri, Forenede Stater, 65401
        • Delbert Day Cancer Institute at PCRMC
      • Rolla, Missouri, Forenede Stater, 65401
        • Mercy Clinic - Rolla - Cancer and Hematology
      • Saint Joseph, Missouri, Forenede Stater, 64506
        • Heartland Regional Medical Center
      • Springfield, Missouri, Forenede Stater, 65807
        • CoxHealth South Hospital
      • Springfield, Missouri, Forenede Stater, 65804
        • Mercy Hospital Springfield
    • Montana
      • Anaconda, Montana, Forenede Stater, 59711
        • Community Hospital of Anaconda
      • Bozeman, Montana, Forenede Stater, 59715
        • Bozeman Deaconess Hospital
      • Great Falls, Montana, Forenede Stater, 59406
        • Benefis Healthcare-Sletten Cancer Institute
    • Nebraska
      • Grand Island, Nebraska, Forenede Stater, 68803
        • CHI Health Saint Francis
    • Nevada
      • Henderson, Nevada, Forenede Stater, 89052
        • OptumCare Cancer Care at Seven Hills
      • Las Vegas, Nevada, Forenede Stater, 89128
        • OptumCare Cancer Care at MountainView
      • Las Vegas, Nevada, Forenede Stater, 89135
        • Alliance for Childhood Diseases/Cure 4 the Kids Foundation
      • Las Vegas, Nevada, Forenede Stater, 89148
        • OptumCare Cancer Care at Fort Apache
      • Las Vegas, Nevada, Forenede Stater, 89102
        • OptumCare Cancer Care at Oakey
      • Las Vegas, Nevada, Forenede Stater, 89103
        • Hope Cancer Care of Nevada
    • New Jersey
      • East Orange, New Jersey, Forenede Stater, 07018-1095
        • Veterans Administration New Jersey Health Care System
      • Woodbury, New Jersey, Forenede Stater, 08096
        • Inspira Medical Center Woodbury
    • New Mexico
      • Albuquerque, New Mexico, Forenede Stater, 87106
        • University of New Mexico Cancer Center
      • Las Cruces, New Mexico, Forenede Stater, 88011
        • Memorial Medical Center-Las Cruces
    • New York
      • Brooklyn, New York, Forenede Stater, 11219
        • Maimonides Medical Center
      • Buffalo, New York, Forenede Stater, 14263
        • Roswell Park Cancer Institute
      • Elmira, New York, Forenede Stater, 14905
        • Arnot Ogden Medical Center/Falck Cancer Center
      • Glens Falls, New York, Forenede Stater, 12801
        • Glens Falls Hospital
      • Lake Success, New York, Forenede Stater, 11042
        • Northwell Health/Center for Advanced Medicine
      • Lake Success, New York, Forenede Stater, 11042
        • North Shore University Hospital
      • New Hyde Park, New York, Forenede Stater, 11040
        • Long Island Jewish Medical Center
      • Sleepy Hollow, New York, Forenede Stater, 10591
        • Phelps Memorial Hospital Center
      • The Bronx, New York, Forenede Stater, 10467
        • Montefiore Medical Center - Moses Campus
      • The Bronx, New York, Forenede Stater, 10468
        • James J Peters VA Medical Center
      • The Bronx, New York, Forenede Stater, 10461
        • Montefiore Medical Center - Einstein Campus
    • North Carolina
      • Asheville, North Carolina, Forenede Stater, 28801
        • Mission Hospital
      • Durham, North Carolina, Forenede Stater, 27705
        • Durham VA Medical Center
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Sanford Bismarck Medical Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Roger Maris Cancer Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Broadway Medical Center
      • Fargo, North Dakota, Forenede Stater, 58102
        • Sanford Clinic North-Fargo
    • Ohio
      • Akron, Ohio, Forenede Stater, 44307
        • Cleveland Clinic Akron General
      • Cleveland, Ohio, Forenede Stater, 44109
        • MetroHealth Medical Center
      • Cleveland, Ohio, Forenede Stater, 44195
        • Cleveland Clinic Foundation
      • Fairview, Ohio, Forenede Stater, 44111
        • Cleveland Clinic Cancer Center/Fairview Hospital
      • Independence, Ohio, Forenede Stater, 44131
        • Cleveland Clinic Cancer Center Independence
      • Mansfield, Ohio, Forenede Stater, 44906
        • Cleveland Clinic Cancer Center Mansfield
      • Mayfield Heights, Ohio, Forenede Stater, 44124
        • Hillcrest Hospital Cancer Center
      • Sandusky, Ohio, Forenede Stater, 44870
        • North Coast Cancer Care
      • Wooster, Ohio, Forenede Stater, 44691
        • Cleveland Clinic Wooster Family Health and Surgery Center
    • Oklahoma
      • Lawton, Oklahoma, Forenede Stater, 73505
        • Cancer Centers of Southwest Oklahoma Research
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • University of Oklahoma Health Sciences Center
      • Oklahoma City, Oklahoma, Forenede Stater, 73120
        • Mercy Hospital Oklahoma City
    • Oregon
      • Portland, Oregon, Forenede Stater, 97239
        • Oregon Health & Science University
      • Portland, Oregon, Forenede Stater, 97227
        • Kaiser Permanente Northwest
    • Pennsylvania
      • Allentown, Pennsylvania, Forenede Stater, 18103
        • Lehigh Valley Hospital-Cedar Crest
      • Bethlehem, Pennsylvania, Forenede Stater, 18017
        • Lehigh Valley Hospital-Muhlenberg
      • Danville, Pennsylvania, Forenede Stater, 17821
        • Geisinger Medical Center
      • Easton, Pennsylvania, Forenede Stater, 18042
        • Easton Hospital
      • Ephrata, Pennsylvania, Forenede Stater, 17522
        • Ephrata Cancer Center
      • Gettysburg, Pennsylvania, Forenede Stater, 17325
        • Adams Cancer Center
      • Hazleton, Pennsylvania, Forenede Stater, 18201
        • Geisinger Medical Center - Cancer Center Hazleton
      • Lebanon, Pennsylvania, Forenede Stater, 17042
        • Sechler Family Cancer Center
      • Lewisburg, Pennsylvania, Forenede Stater, 17837
        • Geisinger Medical Oncology - Lewisburg
      • Philadelphia, Pennsylvania, Forenede Stater, 19104
        • University of Pennsylvania/Abramson Cancer Center
      • Phoenixville, Pennsylvania, Forenede Stater, 19460
        • Phoenixville Hospital
      • Pottstown, Pennsylvania, Forenede Stater, 19464
        • Pottstown Hospital
      • Pottsville, Pennsylvania, Forenede Stater, 17901
        • Geisinger Cancer Services - Pottsville
      • Reading, Pennsylvania, Forenede Stater, 19605
        • Penn State Health Saint Joseph Medical Center
      • Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
        • Geisinger Wyoming Valley/Henry Cancer Center
      • Williamsport, Pennsylvania, Forenede Stater, 17701
        • UPMC Susquehanna
      • York, Pennsylvania, Forenede Stater, 17401
        • WellSpan Health-York Hospital
    • South Carolina
      • Charleston, South Carolina, Forenede Stater, 29401
        • Ralph H Johnson VA Medical Center
      • Easley, South Carolina, Forenede Stater, 29640
        • Prisma Health Cancer Institute - Easley
      • Greenville, South Carolina, Forenede Stater, 29607
        • Saint Francis Cancer Center
      • Greenville, South Carolina, Forenede Stater, 29601
        • Saint Francis Hospital
      • Greenville, South Carolina, Forenede Stater, 29605
        • Prisma Health System Cancer Institute - Eastside
      • Greenville, South Carolina, Forenede Stater, 29605
        • Prisma Health System Cancer Institute - Faris
      • Greenwood, South Carolina, Forenede Stater, 29646
        • Self Regional Healthcare
      • Greer, South Carolina, Forenede Stater, 29650
        • Prisma Health System Cancer Institute - Greer
      • Reidville, South Carolina, Forenede Stater, 29605
        • Prisma Health System Cancer Institute - Butternut
      • Seneca, South Carolina, Forenede Stater, 29672
        • Prisma Health System Cancer Institute - Seneca
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • Spartanburg Medical Center
      • Spartanburg, South Carolina, Forenede Stater, 29307
        • Prisma Health System Cancer Institute - Spartanburg
    • South Dakota
      • Aberdeen, South Dakota, Forenede Stater, 57401
        • Avera Cancer Institute-Aberdeen
      • Rapid City, South Dakota, Forenede Stater, 57701
        • Monument Health Rapid City Hospital
      • Sioux Falls, South Dakota, Forenede Stater, 57105
        • Avera Cancer Institute
      • Sioux Falls, South Dakota, Forenede Stater, 57104
        • Sanford Cancer Center Oncology Clinic
      • Sioux Falls, South Dakota, Forenede Stater, 57117
        • Sanford USD Medical Center - Sioux Falls
    • Tennessee
      • Memphis, Tennessee, Forenede Stater, 38120
        • Baptist Memorial Hospital and Cancer Center-Memphis
      • Nashville, Tennessee, Forenede Stater, 37208
        • Meharry Medical College
    • Texas
      • Austin, Texas, Forenede Stater, 78701
        • Dell Seton Medical Center at The University of Texas
      • Dallas, Texas, Forenede Stater, 75390
        • UT Southwestern/Simmons Cancer Center-Dallas
      • Richardson, Texas, Forenede Stater, 75080
        • UT Southwestern Clinical Center at Richardson/Plano
      • San Antonio, Texas, Forenede Stater, 78229
        • University of Texas Health Science Center at San Antonio
    • Virginia
      • Fishersville, Virginia, Forenede Stater, 22939
        • Augusta Health Center for Cancer and Blood Disorders
    • Washington
      • Auburn, Washington, Forenede Stater, 98001
        • MultiCare Auburn Medical Center
      • Bremerton, Washington, Forenede Stater, 98310
        • Harrison HealthPartners Hematology and Oncology-Bremerton
      • Bremerton, Washington, Forenede Stater, 98310
        • Harrison Medical Center
      • Gig Harbor, Washington, Forenede Stater, 98335
        • MultiCare Gig Harbor Medical Park
      • Poulsbo, Washington, Forenede Stater, 98370
        • Harrison HealthPartners Hematology and Oncology-Poulsbo
      • Puyallup, Washington, Forenede Stater, 98372
        • MultiCare Good Samaritan Hospital
      • Seattle, Washington, Forenede Stater, 98109
        • Fred Hutchinson Cancer Research Center
      • Seattle, Washington, Forenede Stater, 98109
        • Seattle Cancer Care Alliance
      • Seattle, Washington, Forenede Stater, 98115
        • University of Washington Medical Center
      • Tacoma, Washington, Forenede Stater, 98405
        • MultiCare Tacoma General Hospital
    • West Virginia
      • Charleston, West Virginia, Forenede Stater, 25304
        • West Virginia University Charleston Division
    • Wisconsin
      • Brookfield, Wisconsin, Forenede Stater, 53045
        • Ascension Southeast Wisconsin Hospital-Elmbrook Campus
      • Burlington, Wisconsin, Forenede Stater, 53105
        • Aurora Cancer Care-Southern Lakes VLCC
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Marshfield Medical Center - EC Cancer Center
      • Fontana, Wisconsin, Forenede Stater, 54937
        • Aurora Health Center-Fond du Lac
      • Franklin, Wisconsin, Forenede Stater, 53132
        • Ascension Saint Francis-Reiman Cancer Center
      • Germantown, Wisconsin, Forenede Stater, 53022
        • Aurora Health Care Germantown Health Center
      • Grafton, Wisconsin, Forenede Stater, 53024
        • Aurora Cancer Care-Grafton
      • Green Bay, Wisconsin, Forenede Stater, 54311
        • Aurora BayCare Medical Center
      • Green Bay, Wisconsin, Forenede Stater, 54301
        • Saint Vincent Hospital Cancer Center Green Bay
      • Green Bay, Wisconsin, Forenede Stater, 53715
        • Saint Vincent Hospital Cancer Center at Saint Mary's
      • Kenosha, Wisconsin, Forenede Stater, 53412
        • Aurora Cancer Care-Kenosha South
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Gundersen Lutheran Medical Center
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Mayo Clinic Health System-Franciscan Healthcare
      • Madison, Wisconsin, Forenede Stater, 53792
        • University of Wisconsin Hospital and Clinics
      • Madison, Wisconsin, Forenede Stater, 53705
        • William S Middleton VA Medical Center
      • Manitowoc, Wisconsin, Forenede Stater, 54220
        • Holy Family Memorial Hospital
      • Marinette, Wisconsin, Forenede Stater, 54143
        • Aurora Bay Area Medical Group-Marinette
      • Marinette, Wisconsin, Forenede Stater, 54143
        • Vince Lombardi Cancer Clinic-Marinette
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Marshfield Medical Center - Marshfield
      • Milwaukee, Wisconsin, Forenede Stater, 53215
        • Aurora Saint Luke's Medical Center
      • Milwaukee, Wisconsin, Forenede Stater, 53233
        • Aurora Sinai Medical Center
      • Milwaukee, Wisconsin, Forenede Stater, 53226
        • Aurora Cancer Care-Milwaukee
      • Minocqua, Wisconsin, Forenede Stater, 54548
        • Marshfield Clinic-Minocqua Center
      • Oshkosh, Wisconsin, Forenede Stater, 54904
        • Ascension Mercy Hospital
      • Oshkosh, Wisconsin, Forenede Stater, 54904
        • Vince Lombardi Cancer Clinic - Oshkosh
      • Racine, Wisconsin, Forenede Stater, 53406
        • Aurora Cancer Care-Racine
      • Racine, Wisconsin, Forenede Stater, 53405
        • Ascension All Saints Hospital
      • Rice Lake, Wisconsin, Forenede Stater, 54868
        • Marshfield Medical Center - Rice Lake
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • Vince Lombardi Cancer Clinic-Sheboygan
      • Stevens Point, Wisconsin, Forenede Stater, 54482
        • Marshfield Clinic Stevens Point Center
      • Summit, Wisconsin, Forenede Stater, 53066
        • Aurora Medical Center in Summit
      • Two Rivers, Wisconsin, Forenede Stater, 54241
        • Vince Lombardi Cancer Clinic-Two Rivers
      • Wauwatosa, Wisconsin, Forenede Stater, 53226
        • Aurora Cancer Care-Milwaukee West
      • Wauwatosa, Wisconsin, Forenede Stater, 53226
        • Ascension Medical Group Southeast Wisconsin-Mayfair Road
      • West Allis, Wisconsin, Forenede Stater, 53227
        • Aurora West Allis Medical Center
      • Weston, Wisconsin, Forenede Stater, 54476
        • Marshfield Clinic-Weston Center
  • Israel
      • Jerusalem, Israel, 9103102
        • Shaare Zedek Medical Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

14 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

Patienter med mistanke om MDS eller MDS/MPN overlapningslidelse, som gennemgår diagnostisk oparbejdning og knoglemarvsvurderinger, og patienter diagnosticeret med MDS inden for 6 måneder efter indskrivning og gennemgår klinisk evaluering og knoglemarvsvurderinger for at bekræfte MDS eller evaluere sygdomsstatus

Beskrivelse

Inklusionskriterier:

  • Mistænkt (f.eks. vedvarende uforklarlig cytopeni, cirkulerende perifere blaster osv.) MDS eller MDS/MPN overlapningslidelser og gennemgår diagnostisk oparbejdning med planlagte knoglemarvsvurderinger eller diagnosticeret med de novo eller terapirelateret MDS inden for 12 måneder efter tilmelding pr. Verdenssundhedsorganisationens (WHO) kriterier1 og gennemgår klinisk evaluering og planlagte knoglemarvsvurderinger for at bekræfte MDS eller for at evaluere sygdomsstatus
  • Knoglemarvsaspiration forventes udført inden for 1 uge efter registrering, og skal i alle tilfælde udføres senest 4 uger efter indskrivning
  • Alder 18 eller ældre
  • Hvis anæmi uden forudgående MDS-diagnose, B12-niveau, serumfolat, middel korpuskulært volumen (MCV), røde blodlegemers distributionsbredde (RDW), ferritin- og jernundersøgelser (jern, total jernbindingskapacitet (TIBC) test og procent mætning) skal udføres inden for 6 måneder.

Ekskluderingskriterier:

  • Forudgående behandling for MDS ved indtræden og gennem tidspunktet for indtræden af ​​knoglemarvsaspirationen
  • Behandling med hæmatopoietiske vækstfaktorer i de foregående 6 måneder
  • Diagnose af en solid tumor eller hæmatologisk malignitet inden for to år før indskrivning, bortset fra in situ kræft i huden (basal eller pladecelle), livmoderhals, blære, bryst eller prostata
  • Behandling med strålebehandling i de to år forud for registrering
  • Ikke-hormonel behandling for malignitet inden for de to år forud for registrering
  • Etableret arveligt knoglemarvssvigtsyndrom
  • Kendt primær diagnose af aplastisk anæmi, klassisk paroxysmal natlig hæmoglobinuri, amegakaryocytisk trombocytopenisk purpura eller stor granulær lymfocytleukæmi
  • Tilmeldt Connect® MDS/AML Disease Registry (NCT01688011)

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Observationsmodeller: Kohorte
  • Tidsperspektiver: Fremadrettet

Kohorter og interventioner

Gruppe / kohorte
Intervention / Behandling
Langsgående
Deltagere med MDS, MDS/MPN overlapsforstyrrelse, AML
Andet: Terapeutisk
Observationsstudie
Tværsnit
Deltagere, der ikke har MDS, MDS/MPN overlapsforstyrrelse eller ICUS og kun har baseline-besøget
Andet: Terapeutisk
Observationsstudie

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Antal døende patienter
Tidsramme: Gennem studieafslutning i gennemsnit 3 år
Dødsfald vil blive rapporteret på skemaer til undersøgelsescaserapporter
Gennem studieafslutning i gennemsnit 3 år

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Antal deltagere, der udvikler sig til akut myeloid leukæmi (AML)
Tidsramme: Gennem studieafslutning i gennemsnit 3 år
Progression til AML vil blive rapporteret på undersøgelsescaserapportskemaer
Gennem studieafslutning i gennemsnit 3 år

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Samarbejdspartnere

National Cancer Institute (NCI)

Efterforskere

  • Studiestol: Mikkael Sekeres, MD, MS, University of Miami
  • Studiestol: Amy DeZern, MD, MHS, Johns Hopkins University

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Hjælpsomme links

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

13. juni 2016

Primær færdiggørelse (Faktiske)

31. juli 2025

Studieafslutning (Faktiske)

31. december 2025

Datoer for studieregistrering

Først indsendt

2. maj 2016

Først indsendt, der opfyldte QC-kriterier

16. maj 2016

Først opslået (Anslået)

17. maj 2016

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

3. februar 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

30. januar 2026

Sidst verificeret

1. november 2025

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • NHLBI-MDS

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

produkt fremstillet i og eksporteret fra U.S.A.

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Abonner