- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02775513
Metabolism of Patients With Genetically Caused Cardiac Arrhythmia
Study Overview
Status
Conditions
Detailed Description
Loss-of-function mutations in voltage-gated potassium channels cause long QT syndrome (LQTS) due to a prolonged cardiac repolarisation phase.
Voltage-gated potassium (Kv-) channels are known for their relation to malignant cardiac arrhythmias, but also play a role in pancreatic alpha- and beta cell hormone secretion, and possibly in incretin hormone secretion. We hypothesised that patients with loss-of-function mutations also exhibit altered hormone release upon glucose ingestion.
Study Type
Enrollment (Anticipated)
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
LQTS Gain of function Matched healthy controls
Exclusion criteria:
none
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
---|
Mutation
Patients with functional mutation in ion channels
|
Control
Matched control
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
glucose homeostasis
Time Frame: 6 hours
|
measured by glucose, insulin, glucagon, GLP-1 and GIP response to glucose (OGTT)
|
6 hours
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
QT
Time Frame: 6 hours
|
cardiac repolarisation
|
6 hours
|
Collaborators and Investigators
Sponsor
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- LQTS
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Long QT Syndrome
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-
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-
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-
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-
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-
KU LeuvenAgentschap voor Innovatie door Wetenschap en TechnologieCompleted
-
KU LeuvenAgentschap voor Innovatie door Wetenschap en TechnologieCompleted
-
NorthShore University HealthSystemUnknownEKG-QT ProlongationUnited States