Prevalence and Consequences of Vitamin D Deficiency in Pregnant Women in Switzerland (PCVDDPWS)

The purpose of this study is to determine the prevalence of vitamin D deficiency among the population of pregnant women receiving prenatal care and giving birth at the investigators' clinic. The further purposes are to identify the population at risk for vitamin D deficiency and to analyse whether vitamin D deficiency is associated with pregnancy complications.

Study Overview

• Status: Completed
• Conditions: Vitamin D Deficiency

• Study Type: Observational
• Enrollment (Actual): 1199

Contacts and Locations

Study Locations

• Switzerland
  • Bern, Switzerland, 3010
    • University Hospital Bern

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

• Sampling Method: Non-Probability Sample

Study Population

All the pregnant women attending prenatal care and giving birth at birth at our clinic

Description

Inclusion Criteria:

• Pregnant women attending prenatal care at our clinic who had a vitamin D blood-testing at admission

Exclusion Criteria:

• Pregnant women lost to follow-up, Birth outside our clinic

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Cross-Sectional

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Prevalence of vitamin D deficiency	Number of patients with vitamin D deficiency after testing of vitamin D blood level at admission for prenatal care in our clinic	Between the 1th and the 36th week of pregnancy

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
BMI as a risk factor for vitamin D deficiency	Presence of an association between the patient's BMI and their vitamin D blood level?	Between the 1th and the 36th week of pregnancy
Ethnicity as a risk factor for vitamin D deficiency	Presence of an association between the patient's ethnicity and their vitamin D blood level?	Between the 1th and the 36th week of pregnancy
Age as risk factor for vitamin D deficiency	Presence of an association between the patient's age and their vitamin D blood level ?	Between the 1th and the 36th week of pregnancy
Period of the year as risk factor for vitamin D deficiency	Presence of an association between the period of the year at the time of the blood testing and the vitamin D blood level?	Between the 1th and the 36th week of pregnancy
Smoking Status as risk factor for vitamin D deficiency	Presence of an association between the patient's smoking status and the vitamin D blood level ?	Between the 1th and the 36th week of pregnancy
Association between vitamin D blood level and gestational diabetes mellitus	Presence of an association between the vitamin D blood level and the occurrence of gestational diabetes mellitus?	Between the 1th and the 36th week of pregnancy
Association between vitamin D blood level and gestational hypertension and preeclampsia	Presence of an association between the vitamin D blood level and the occurrence of gestational hypertension and preeclampsia ?	Between the 1th and the 36th week of pregnancy

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Association between vitamin D blood level and the mode of delivery at birth	Presence of an association between the vitamin D blood level and the mode of delivery (Vaginal delivery, instrumentalized delivery, primary and secondary cesarean)?	At delivery time
Association between vitamin D blood level and the gestational age at delivery	Presence of an association between the vitamin D blood level and the gestational age at delivery? Occurrence of preterm birth (before 37W) or postterm birth (after 40W)?	At delivery time
Association between vitamin D blood level and newborn growth	Presence of an association between vitamin D blood level and the occurrence of intrauterin growth retardation or small-for-gestational age child? With assessment of measure like length, weight, head perimeter.	From week 1 until birth

Collaborators and Investigators

• Sponsor: University Hospital Inselspital, Berne
• Collaborators: Significantis GmbH
• Investigators: Study Director: Daniel Surbek, Professor, University Hospital Inselspital, Berne

Publications and helpful links

General Publications

• Christoph P, Challande P, Raio L, Surbek D. High prevalence of severe vitamin D deficiency during the first trimester in pregnant women in Switzerland and its potential contributions to adverse outcomes in the pregnancy. Swiss Med Wkly. 2020 May 28;150:w20238. doi: 10.4414/smw.2020.20238. eCollection 2020 May 18.

Study record dates

Study Major Dates

• Study Start: October 1, 2015
• Primary Completion (Actual): February 1, 2016
• Study Completion (Actual): February 1, 2016

Study Registration Dates

• First Submitted: September 8, 2016
• First Submitted That Met QC Criteria: September 13, 2016
• First Posted (Estimate): September 19, 2016

Study Record Updates

• Last Update Posted (Estimate): September 19, 2016
• Last Update Submitted That Met QC Criteria: September 13, 2016
• Last Verified: September 1, 2016

More Information

Terms related to this study

• Keywords: Vitamin D; Pregnancy
• Additional Relevant MeSH Terms: Nutrition Disorders; Avitaminosis; Deficiency Diseases; Malnutrition; Vitamin D Deficiency
• Other Study ID Numbers: 2015-00063

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No