Clinical Trials Sponsored by Significantis GmbH

Total 3269 results

University Hospital Inselspital, Berne
Significantis GmbH

Completed

Prevalence and Consequences of Vitamin D Deficiency in Pregnant Women in Switzerland (PCVDDPWS)

Vitamin D Deficiency

Switzerland
AIO-Studien-gGmbH
Servier Deutschland GmbH; Crolll Gmbh

Active, not recruiting

2nd-line Therapy With Nal-IRI After Gem/Nab-pac in Advanced Pancreatic Cancer - Predictive Role of 1st-line Therapy (PREDICT)

Metastatic Pancreatic Cancer | Locally Advanced Pancreatic Cancer

Germany
VisionHealth GmbH
Thoraxklinik-Heidelberg gGmbH

Recruiting

Effects of the Kata® Inhalations-App on Inhaler Handling Errors, Adherence, and Asthma Control in Patients With Asthma.

Asthma

Germany
AIO-Studien-gGmbH
Pfizer; Crolll Gmbh

Recruiting

Role of PRoactivE Coaching on PAtient REported Outcome in Advanced or Metastatic RCC Treated With Sunitinib or a Combination of Pembrolizumab + Axitinib or Avelumab + Axitinib in First Line Therapy (PREPARE)

Renal Cell Carcinoma, Metastatic | Renal Cell Cancer, Recurrent

Germany
AIO-Studien-gGmbH
Celgene; ClinAssess GmbH

Completed

Neoadjuvant Plus Adjuvant or Only Adjuvant Nab- Paclitaxel Plus Gemcitabine for Resectable Pancreatic Cancer (NEONAX)

Resectable Pancreatic Cancer | Ductal Adenocarcinoma of the Pancreas

Germany
Thoraxklinik-Heidelberg gGmbH
Erbe Elektromedizin GmbH

Completed

EBUS Guided Cryobiopsies With Ultrathin Cryoprobe in Patients With Peripheral Pulmonary Nodules - a Feasibility Study

Transbronchial Cryobiopsy

Germany
AIO-Studien-gGmbH
Sanofi; ClinAssess GmbH

Terminated

A Study of Cabazitaxel for Patients With Breast or Lung Cancer and Recurrent or Progressive Brain Metastases - Cabazitaxel for Brain Metastases (CaBaMet) (CaBaMet)

Breast Cancer | Lung Cancer | Recurrent Brain Metastases | Progressive Brain Metastases

Germany
AIO-Studien-gGmbH
Amgen; ClinAssess GmbH

Completed

FOLFOXIRI With or Without Panitumumab in Metastatic Colorectal Cancer (VOLFI) (VOLFI)

Metastatic Colorectal Cancer

Germany
AIO-Studien-gGmbH
Amgen; ClinAssess GmbH

Completed

Maintenance Therapy With 5-FU/FA Plus Panitumumab vs. 5-FU/FA Alone After Prior Induction and Re-induction After Progress for 1st-line Treatment of Metastatic Colorectal Cancer (PanaMa)

Metastatic Colorectal Cancer

Germany
WiSP Wissenschaftlicher Service Pharma GmbH
Mundipharma Research GmbH & Co KG; Klinikum Leverkusen gGmbH; ribosepharm GmbH

Completed

Bendamustine Versus Fludarabine in Chronic Lymphocytic Leukemia (CLL)

Chronic Lymphocytic Leukemia

Germany
AIO-Studien-gGmbH
Celgene Corporation; ClinAssess GmbH

Completed

First-line Treatment of Metastatic Pancreatic Cancer With Nab-paclitaxel and Gemcitabine (ALPACA)

Adenocarcinoma of the Pancreas | Metastatic Pancreatic Cancer

Germany
AIO-Studien-gGmbH
Merck Serono GmbH, Germany

Terminated

Neoadjuvant Bintrafusp Alfa in Patients With Resectable Biliary Tract Cancer (NEOBIL)

Cholangiocarcinoma | Biliary Tract Cancer

Germany
AIO-Studien-gGmbH
Celgene Corporation; ClinAssess GmbH

Completed

Trial to Investigate Intensified Neoadjuvant Chemotherapy in Locally Advanced Pancreatic Cancer (NEOLAP)

Ductal Adenocarcinoma of the Pancreas

Germany
Infectopharm Arzneimittel GmbH
Gesellschaft für Therapieforschung mbH

Recruiting

Moisturizer Mediated Prevention of Symptoms of Atopic Dermatitis in Early Childhood (MOPAD)

Atopic Dermatitis | Infant, Newborn

Germany
Infectopharm Arzneimittel GmbH
Gesellschaft für Therapieforschung mbH

Completed

5% KOH Solution vs. Placebo and Diclofenac Gel for the Treatment of Actinic Keratosis (KOHDIAK)

Actinic Keratosis

Germany
Infectopharm Arzneimittel GmbH
Gesellschaft für Therapieforschung mbH

Completed

Treatment of Actinic Keratosis With 5% KOH Solution (TAKKOH)

Actinic Keratoses

Germany
AIO-Studien-gGmbH
Universitätsklinikum Hamburg-Eppendorf; Merck Serono GmbH, Germany; Pierre Fabre...

Recruiting

Neoadjuvant Encorafenib, Binimetinib and Cetuximab for Patients With BRAF V600E Mutated/pMMR Localized Colorectal Cancer (NeoBRAF)

Colorectal Cancer | Colon Cancer | BRAF V600 Mutation | BRAF V600E | Localized Cancer

Germany
AIO-Studien-gGmbH
Amgen; Assign Data Management and Biostatistics GmbH; Assign Clinical Research...

Terminated

Cisplatin and 5-FU +/- Panitumumab for Patients With Nonresectable,Advanced or Metastatic Esophageal Squamous Cell Cancer (POWER)

Esophageal Squamous Cell Cancer

Germany
afreeze GmbH
Raffeiner GmbH

Recruiting

Treatment Success With the CoolLoop Cryoablation System

Heart Diseases | Cardiovascular Diseases | Atrial Fibrillation | Arrhythmias, Cardiac | Paroxysmal Atrial Fibrillation | Persistent Atrial Fibrillation

Austria, Germany
Nano4Imaging GmbH
CERES GmbH

Completed

Post-market Clinical Follow-up Study With Magnetic Resonance Imaging Conditional Guide Wire (MRWIREPMCF)

Congenital Heart Defect

Germany, United Kingdom
neuroloop GmbH
MAXIS GmbH

Terminated

The Baroloop Study

Hypertension

Netherlands
cortEXplore GmbH
Raffeiner GmbH

Completed

Navigation Support With Mixed Reality With CORTEXPLORER MED (CXmed)

Cranial Aneurysm

Austria
CytoSorbents Europe GmbH
BRAHMS GmbH; MedInnovation GmbH

Recruiting

A RCT to Assess the Performance of CytoSorb for Shock Reversal in Patients With Vasoplegic Septic Shock (PROCYSS)

Septic Shock

Germany
Infectopharm Arzneimittel GmbH
GKM Gesellschaft für Therapieforschung mbH

Not yet recruiting

Prophylaxis of COVID-19 Disease With Ivermectin in COVID-19 Contact Persons [German: Prophylaxe Der COVID-19-Erkrankung Mit Ivermectin Bei COVID-19 Kontaktpersonen]

Covid19
afreeze GmbH
Accovion GmbH

Terminated

CoolLoop Paroxysmal Atrial Fibrillation (CoolLoop PAF)

Pathologic Processes | Heart Diseases | Cardiovascular Diseases | Arrhythmias, Cardiac | Atrial Fibrillation (Paroxysmal)

Austria, Germany, Switzerland
AdvanceCor GmbH
Procorde GmbH

Completed

Safety, Pharmacokinetic and -Dynamic Study of PR-15, an Inhibitor of Platelet Adhesion (PR-15/01)

Myocardial Infarction | Stroke | Thrombosis | Acute Coronary Syndrome

Germany
Institut fur Diabetes Karlsburg GmbH
Aktivmed GmbH; Beurer GmbH; IME-DC GmbH; Medisana GmbH

Completed

System Accuracy of 12 Bloog Glucose Monitoring Systems

Diabetes Mellitus

Germany
AIO-Studien-gGmbH
Amgen; WiSP Wissenschaftlicher Service Pharma GmbH

Completed

ECX + Panitumumab vs. ECX Alone in Locally Advanced Gastric Cancer or Cancer of the Gastroesophageal Junction (NEOPECX)

Stomach Neoplasms | Gastroesophageal Junction Neoplasms

Germany
GWT-TUD GmbH
ClinStat GmbH

Completed

Factor XA - Inhibition in RENal Patients With Non-valvular Atrial Fibrillation - Observational Registry (XARENO)

Chronic Kidney Disease (CKD) | Non-valvular Atrial Fibrillation (NVAF)

Germany, Austria, France, Belgium, Switzerland
Onkovis GmbH
AKP Freiburg GmbH

Completed

A Non Interventional Study With Paclitaxel Onkovis (Paclitaxel) Utilized for the Treatment of Cancer

Carcinoma

Germany
Biofrontera Bioscience GmbH
Accovion GmbH

Completed

Evaluation of Safety and Efficacy of BF-200 ALA for the Treatment of Actinic Keratosis With Photodynamic Therapy

Actinic Keratosis
Onkovis GmbH
AKP Freiburg GmbH

Completed

A Non Interventional Study With Doce Onkovis (Docetaxel) Utilized for the Treatment of Cancer

Carcinoma

Germany
Biolux Technology GmbH
medXteam GmbH

Recruiting

Study of the Use of Orthopulse Photobiomodulation

Orthodontics

United States
Croma-Pharma GmbH
Proinnovera GmbH

Completed

THIODERM STRONG Compared to Juvéderm® VOLUMA® Lidocaine for the Treatment of Midface Volume Deficit (TIMI)

Mid Face Volume Deficit

Austria
Biofrontera Bioscience GmbH
Accovion GmbH

Completed

Safety and Efficacy Study for the Treatment of Non-Aggressive Basal Cell Carcinoma With Photodynamic Therapy

Basal Cell Carcinoma (BCC)

Germany
Glycotope GmbH
Glycotope Biotechnology GmbH

Completed

Single Dose FSH-GEX™ in Healthy Volunteers

Female Infertility

Netherlands
Glycotope GmbH
Glycotope Biotechnology GmbH

Completed

Multiple Dose FSH-GEX(TM) in Healthy Volunteers

Female Infertility

Netherlands
Herrmann Apparatebau GmbH
CERES GmbH

Unknown

Evaluation of Performance and Safety of Colonic Irrigation With the Colon Hydromat as a Non-oral Bowel Preparation for Colonoscopy

Colonic Irrigation

Germany
Onkovis GmbH
AKP Freiburg GmbH

Completed

A Non Interventional Study With Oxaliplatin Onkovis (Oxaliplatin) Utilized for the Treatment of Cancer

Carcinoma

Germany
Onkovis GmbH
AKP Freiburg GmbH

Completed

A Non Interventional Study With Irinotecan Onkovis (Irinotecan) Utilized for the Treatment of Cancer

Carcinoma

Germany
GWT-TUD GmbH
Ardeypharm GmbH

Completed

Investigation of the Effect of E.-Coli-Nissle as Supporting Therapy to Standard Care of Diabetes Mellitus Type II (PUNiDIA)

Diabetes Mellitus Type II

Germany
Johnson & Johnson GmbH
Anfomed GmbH

Completed

"EASY EFFECTIVE SMOKELESS" With NICORETTE®

Tobacco Smoking Behavior | Stereotyped Behavior

Germany
Croma-Pharma GmbH
Proinnovera GmbH

Not yet recruiting

THIODERM ELATE for Volume Augmentation in Lips (TIVOLI)

Lip; Anomaly

Austria
Croma-Pharma GmbH
Proinnovera GmbH

Active, not recruiting

THIODERM ELATE for Augmentation of Very Thin, Thin, and Moderately Thick Lips (TILI)

Lip Abnormality

Austria
BSN Medical GmbH
proDERM GmbH

Completed

Feasibility Study Focusing on Fit of Made-to-measure Compression Garments in Healthy Subjects II

Product Use Issue

Germany
Glycotope GmbH
Glycotope Biotechnology GmbH

Completed

TrasGEX™: Phase 1 Study in Cancer Patients

Solid Tumors

Austria, Germany, Italy, Switzerland
Vasopharm GmbH
Winicker Norimed GmbH

Completed

Effects of the NO-synthase Inhibitor VAS203 on Renal Function in Healthy Volunteers

Renal Function Impairment in Healthy Volunteers

Germany
bene-Arzneimittel GmbH
Medaimun GmbH

Completed

Mucolytic Effectiveness of Tacholiquine ® in Chronic Bronchitis (Tacho-COPD)

Pulmonary Disease, Chronic Obstructive | Bronchitis, Chronic

Germany
Infectopharm Arzneimittel GmbH
INPADS GmbH; Dr. Oestreich + Partner GmbH

Recruiting

Fosfomycin i.v. for Treatment of Severely Infected Patients (FORTRESS)

Respiratory Tract Infections | Sepsis | Encephalitis | Bacterial Infections | Intraabdominal Infections | Bacteremia | Skin Diseases, Bacterial | Pneumonia, Bacterial | Urinary Tract Infections | Meningitis, Bacterial | Central Nervous System Bacterial Infections | Soft Tissue Infections | Endocarditis, Bacterial | Bone Diseases, Infectious and other conditions

Germany, Austria, Greece, Italy, United Kingdom
ikfe-CRO GmbH
MLM Medical Labs GmbH; Ikfe GmbH

Completed

Effects of Linagliptin on Endothelial- , Renal-, and Retinal Function in Patients With Hypertension and Albuminuria

Albuminuria | Arterial Hypertension

Germany

Clinical Trials Sponsored by Significantis GmbH

Sponsors and Collaborators

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CROs in Panama

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