Abnormal Placenta Plant Disease Early Diagnosis and Individualized Treatment Research

As the "two-child" policy implementation, caesarean women's clinical pregnancy is a huge problem again, Especially the placenta planting abnormal disease is a serious threat to the maternal health and life. Through this research, the investigators can obtain relevant epidemiological data and provide objective data for the department of public health policy; Predicting an placenta abnormal planting early diagnosis model was constructed, it will fill the blank in this field, and high-risk groups in the early stages of pregnancy will be taken proper disposal, the related complications will be reduced to ensure the safety of maternal.

Study Overview

• Status: Unknown
• Conditions: Scarred Uterus

Detailed Description

This study focus on four hands: (1) to investigate different types of gestational sac implantation for pregnancy in caesarean women of childbearing age;(2) to explore the relationship between abnormal placenta planting disease in middle-late pregnancy and the different types of scar pregnancy (3) to explore the the value of ultrasound and serological markers for early diagnosis of placenta planting disease from scar pregnancy; (4) to compare the end and the influence of health economy of different termination method on scar pregnancy.

• Study Type: Observational
• Enrollment (Anticipated): 3000

Contacts and Locations

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

• Sampling Method: Probability Sample

Study Population

pregnant women with scar uterus

Description

Inclusion Criteria:

• Single pregnancies with once cesarean section history
• see a doctor before gestational 8 weeks in our study center
• will continue to pregnancy, high patient compliance

Exclusion Criteria:

• twins or multiple pregnancies
• hysteromyoma or adenomyoma stripping history
• history of intrauterine adhesions

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

Number of groups / cohorts

4

Cohorts and Interventions

Group / Cohort
Shanghai First Maternity and Infant Hospital
the Putuo District Maternity and Child Health Care Hospital
the Xinhua hospital affiliated to Shanghai jiaotong University
The Sixth people's hospital of Shanghai

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Placenta implanted	up to 37 gestational weeks

Secondary Outcome Measures

Outcome Measure	Time Frame
Placenta previa	up to 37 gestational weeks

Collaborators and Investigators

• Sponsor: Shanghai First Maternity and Infant Hospital
• Investigators: Principal Investigator: Hao Ying, PHD, Shanghai First Maternity and Infant Hospital

Study record dates

Study Major Dates

• Study Start: December 1, 2016
• Primary Completion (Anticipated): December 1, 2018
• Study Completion (Anticipated): December 1, 2018

Study Registration Dates

• First Submitted: October 22, 2016
• First Submitted That Met QC Criteria: October 25, 2016
• First Posted (Estimate): October 27, 2016

Study Record Updates

• Last Update Posted (Actual): August 1, 2017
• Last Update Submitted That Met QC Criteria: July 30, 2017
• Last Verified: July 1, 2017

More Information

Terms related to this study

• Keywords: Early diagnosis; Scar pregnancy; Placenta planting abnormal disease; Individualized treatment
• Additional Relevant MeSH Terms: Pathologic Processes; Disease
• Other Study ID Numbers: Yinghao

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: Undecided
• IPD Plan Description: There are 6 hospitals participated this study, we need get their agreement to share data.