Correspondence of Folate Dietary Intake and Biomarker Data

Correspondence of Dietary Intake and Biomarker Data

This NHANES analysis compares self-reported dietary folate with serum and red blood cell folate status in U.S. adults.

Study Overview

• Status: Completed
• Conditions: Folate Deficiency
• Intervention / Treatment: Other: No intervention

Detailed Description

Background: Public health concerns of both low and high folate status exist in the U.S. Recent publications have questioned the utility of self-reported dietary intake data in research and monitoring.

Objective: The purpose of this analysis was to examine the relationship between self-reported folate intakes and folate status biomarkers, and to evaluate their usefulness for several types of applications.

Design: Usual dietary intakes of folate were examined using the National Cancer Institute (NCI) method to adjust 2, 24-hour dietary recalls (including dietary supplements) for within-person variation and compared these intakes with serum and red blood cell (RBC) folate among 4,878 non-pregnant, non-lactating participants ≥19y in NHANES 2011-2012, a nationally representative, cross-sectional survey, with respect to consistency across prevalence estimates and rank order comparisons.

• Study Type: Observational
• Enrollment (Actual): 4878

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 19 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

NHANES is a nationally-representative, cross-sectional study of nutrition and health for individuals residing in the U.S.

Description

Inclusion Criteria:

• adults, ages 19+ years

Exclusion Criteria:

• missing data
• non-pregnant
• non-lactating

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Folate status	Comparison of folate in diet and blood	Up to 24 months

Collaborators and Investigators

• Sponsor: National Institute of Health and Nutrition

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2011
• Primary Completion (Actual): December 31, 2012
• Study Completion (Actual): December 31, 2012

Study Registration Dates

• First Submitted: March 14, 2017
• First Submitted That Met QC Criteria: March 23, 2017
• First Posted (Actual): March 24, 2017

Study Record Updates

• Last Update Posted (Actual): March 24, 2017
• Last Update Submitted That Met QC Criteria: March 23, 2017
• Last Verified: March 1, 2017

More Information

Terms related to this study

• Keywords: Folic Acid; Folate; NHANES
• Additional Relevant MeSH Terms: Nutrition Disorders; Avitaminosis; Deficiency Diseases; Malnutrition; Vitamin B Deficiency; Folic Acid Deficiency
• Other Study ID Numbers: ODS2015_1

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No