Partial hepatectomy in Hepatocellular Carcinoma and Rupture, Spontaneous and Rupture Liver - Clinical Trials Registry

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Procedure: Partial hepatectomy

Detailed Description

To investigate the best treatment for hepatocellular carcinoma rupture, transcatheter arterial embolization or partial hepatectomy. Furthermore, to discuss the choice of emergency or staged hepatectomy.

Study Type

Observational

Enrollment (Actual)

216

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

15 years to 76 years (Child, Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

From January 2005 to June 2015, all patients complied with the criteria mentioned above who received partial hepatectomy or non-surgical at our center were included in this study.

Description

Inclusion Criteria:

Being diagnosed as hepatocellular carcinoma with tumor rupture; with complete data and without loss of follow-up

Exclusion Criteria:

Without complete data; with loss of follow-up; not hepatocellular carcinoma based on pathological diagnosis

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Overall survival of all patients Time Frame: 5 years	Overall survival difference between the partial hepatectomy group and the non-surgical group	5 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Postoperative peritoneal dissemination Time Frame: 5 years	Postoperative peritoneal dissemination diagnosed by imaging examination	5 years
Recurrence-free survival of all patients Time Frame: 5 years	Recurrence-free survival difference between the partial hepatectomy group and the non-surgical group	5 years
Overall survival of partial hepatectomy patients Time Frame: 5 years	Overall survival difference between the emergency partial hepatectomy group and the staged partial hepatectomy group	5 years
Recurrence-free survival of partial hepatectomy patients Time Frame: 5 years	Recurrence-free survival difference between the emergency partial hepatectomy group and the staged partial hepatectomy group	5 years
Overall survival of staged partial hepatectomy patients Time Frame: 5 years	Overall survival difference between the staged early partial hepatectomy group and the staged late partial hepatectomy group	5 years
Recurrence-free of staged partial hepatectomy patients Time Frame: 5 years	Recurrence-free survival difference between the staged early partial hepatectomy group and the staged late partial hepatectomy group	5 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Huazhong University of Science and Technology

Investigators

Study Chair: Xiao-ping Chen, PHD, Huazhong University of Science and Technology

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2005

Primary Completion (Actual)

June 1, 2015

Study Completion (Actual)

December 1, 2017

Study Registration Dates

First Submitted

April 4, 2018

First Submitted That Met QC Criteria

May 3, 2018

First Posted (Actual)

May 4, 2018

Study Record Updates

Last Update Posted (Actual)