Lithuanian Atletes' Aortic Diameter
August 31, 2018 updated by: Agne Slapsinskaite
Lithuanian Athletes' Aortic Root Diameter
Recent developments in football have seen the sudden death of young football player due to aortic rupture hence reinforcing the controversy of football as a field with substantial risk for sudden cardiac arrest and death.
Moreover, there is an argument that aortic dilatation and the subsequent event of thoracic aortic aneurysm may be an occupational disease due to the nature of some vocations (i.e., military and security personnel, blue collar workers, weightlifters, athletes etc.).
Of particular importance, there is some evidence that elite athletic training is associated with small but significantly larger aortic root diameter.
The purpose of this study was to investigate aortic root adaptation to physical workload and to determine if aortic root's and left ventricle sizes are contingent upon the physical workload
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
A preliminary data was collected from a total of 944 subjects in Kaunas Sports Medicine Centre during the recruiting period in 2014-2015. Final data analysis consisted of 151 Caucasian subjects who met the inclusion criteria.
All subjects underwent two-dimensional (2D) transthoracic echocardiography (TTE) procedure. Prior to performing 2D TTE, subjects' arterial blood pressure, heart rate, height, weight, and self-reported physical activity levels were measured.
The Ultrasound system CX50 (Philips Ultrasound, Philips Healthcare, Philips Medical Systems Nederland, USA) - with transducer S5-1 was used in this study. Two physicians performed 2D TTE and averages for all variables of interest were computed. The measurements of aortic root and the left ventricle were drawn upon the guidelines of the American Society of Echocardiography and the European Association of Cardiovascular Imaging.
The maximal diameter of the sinuses of Valsalva was measured at end-diastole, in a strictly perpendicular plane to that of the long axis of the aorta using the edge to leading edge (L-L) convention. The aortic annulus was measured at midsystole from inner edge to inner edge (I-I). This was done in order to obtain the rounder shape and bigger diameter of aortic annulus.
Study Type
Observational
Enrollment (Actual)
151
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
16 years to 35 years (ADULT, CHILD)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
The subjects were divided into groups according to gender (i.e., female, male), physical activity (i.e., athletes, non-athletes) and physical activity type (i.e., strength and endurance sports).
Of the 151 subjects, 122 were athletes (41 females and 81 males) and 29 were non-athletes (14 females and 15 males).
Of the 41 female athletes, 32 were endurance athletes, and 9 strength athletes.
From 81 male athletes, 56 were endurance athletes, and 25 were strength athletes.
Description
Inclusion Criteria:
- A total of 2D transthoracic echocardiography performed in Kaunas Sports Medicine Centre 2014-2015.
- Age range 16- 35 years, given the literature definition of 'young' and 'old' athletes as < 35 and > 35 years.
- Physical activity levels (athletes or non-athletes). Individuals who participated in sports for more than 4 years and 4.5 hours per week were included in the group of athletes. Individual who were active for less than 4 years and/or 4.5 hours per week were classified as non-athletes.
- Physical activity type (endurance and strength sports).
- No current or previous history cardiovascular diseases.
- No activity on the test day.
- Consent to participate in the study.
Exclusion Criteria:
- No 2D transthoracic echocardiography.
- Age below 16 or over 35.
- Involvement in sports for less than 4 years and 4.5 hours per week.
- Sports branches not included in the list of endurance or strength sports (i.e., sprint, high jump, etc.).
- Cardiovascular disease (i.e., hypertonic disease, Marfan syndrome, bicuspid aortic valve, detected cardiomyopathy, etc.).
- Physical activity on the echocardiography test day.
- No content to participate in the study.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
|---|---|
|
Athletes
122 were athletes (41 females and 81 males).
Of the 41 female athletes, 32 were endurance athletes, and 9 strength athletes.
From 81 male athletes, 56 were endurance athletes, and 25 were strength athletes.
|
The impact of training on cardiac structure and function depends on the type, intensity and duration of the activity, as well as previous physical activity engagement, genetics and gender type.
More knowledge about cardiac pathophysiologic training adaptation is needed.
|
|
Non-athletes
29 were non-athletes (14 females and 15 males)
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Measurement of aortic root at aortic valve annulus (AA)
Time Frame: Long-term adaptation more when 4 years of physical activity with 4.5 hours per week training sessions
|
Changes in aortic root at aortic valve annulus (AA) and at individuals.
|
Long-term adaptation more when 4 years of physical activity with 4.5 hours per week training sessions
|
|
Measurement of aortic root at sinus of Valsalva (VS)
Time Frame: Long-term adaptation more when 4 years of physical activity with 4.5 hours per week training sessions
|
Changes in aortic root at sinus of Valsalva (VS) individuals.
|
Long-term adaptation more when 4 years of physical activity with 4.5 hours per week training sessions
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Measurement of values of the left ventricle (LV): LV end-diastolic diameter (LVEDD)
Time Frame: Long-term adaptation more when 4 years of physical activity with 4.5 hours per week training sessions
|
Changes values of the left ventricle (LV): LV end-diastolic diameter (LVEDD)
|
Long-term adaptation more when 4 years of physical activity with 4.5 hours per week training sessions
|
|
Measurement of values of interventricular septum thickness in diastole (IVSTd)
Time Frame: Long-term adaptation more when 4 years of physical activity with 4.5 hours per week training sessions
|
Changes values of interventricular septum thickness in diastole (IVSTd)
|
Long-term adaptation more when 4 years of physical activity with 4.5 hours per week training sessions
|
|
LV posterior wall thickness in diastole (LVPWTd)
Time Frame: Long-term adaptation more when 4 years of physical activity with 4.5 hours per week training sessions
|
Changes values of LV posterior wall thickness in diastole (LVPWTd)
|
Long-term adaptation more when 4 years of physical activity with 4.5 hours per week training sessions
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
September 1, 2014
Primary Completion (ACTUAL)
September 30, 2015
Study Completion (ACTUAL)
September 30, 2015
Study Registration Dates
First Submitted
August 29, 2018
First Submitted That Met QC Criteria
August 30, 2018
First Posted (ACTUAL)
September 4, 2018
Study Record Updates
Last Update Posted (ACTUAL)
September 5, 2018
Last Update Submitted That Met QC Criteria
August 31, 2018
Last Verified
August 1, 2018
More Information
Terms related to this study
Other Study ID Numbers
- Kaunas Sport Medicine Centre
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.