Chronic Infections on Articular Prostheses With C. Acnes Diagnosed by Specific PCR

Chronic Infections on Articular Prostheses With C. Acnes Diagnosed by Specific PCR : Descriptive Study of 6 Patients

Osteaoarticular infection due to C. acnes are known to be of late onset, causing chronic infection possibly pauci-symptomatic. Osteaoarticular infection due to C. acnes represents a diagnostic challenge, since C. acnes is slow and difficult to grow, and can also be considered a contaminant.A 16S universal PCR bacteriological diagnosis has been proposed but is lacking of sensitivity. A specific C. acnes PCR was developed in 2010, but is not used routinely.

Study Overview

• Status: Completed
• Conditions: Bone and Joint Infection
• Intervention / Treatment: Other: Prosthetic joint infection with Cutibacterium acnes

• Study Type: Observational
• Enrollment (Actual): 6

Contacts and Locations

Study Locations

• France
  • Lyon, France, 69004
    • Hospices Civils de Lyon

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 100 years (Adult, Older Adult)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

patients having had infection prothesis vith C. acnes identified by PCR and managed at the croix rousse hospital

Description

Inclusion Criteria:

• patients having had infection prothesis vith C. acnes identified by PCR

Exclusion Criteria:

• none

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Retrospective

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Prosthetic joint infection with Cutibacterium acnes; Chronic infections on articular prostheses with Cutibacterium acnes diagnosed by specific PCR	Other: Prosthetic joint infection with Cutibacterium acnes; patients having a prosthesis infection with C.acnes identified by specific PCR

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Rate of diagnostic delay	time between surgery and detection of C. acnes by PCR	Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
rate of radiologic signs	prosthesis loosening or not	Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
rate of duration of antibiotherapy	measures of duration of the antibiotherapy	Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
rate of use of this diagnostic	descriptions of patients managed with this diagnostic	Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption

Collaborators and Investigators

• Sponsor: Hospices Civils de Lyon
• Investigators: Study Director: Tristan Ferry, Md,PhD, HCL

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2016
• Primary Completion (Actual): March 1, 2017
• Study Completion (Actual): February 1, 2018

Study Registration Dates

• First Submitted: February 20, 2019
• First Submitted That Met QC Criteria: February 20, 2019
• First Posted (Actual): February 22, 2019

Study Record Updates

• Last Update Posted (Actual): February 22, 2019
• Last Update Submitted That Met QC Criteria: February 20, 2019
• Last Verified: February 1, 2019

More Information

Terms related to this study

• Keywords: Propionibacterium acnes; bone and joint infection; Cutibacterium acnes
• Additional Relevant MeSH Terms: Pathologic Processes; Disease Attributes; Infections; Communicable Diseases
• Other Study ID Numbers: 18-031

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: Undecided

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No