- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04081285
Epigenetic Biomarkers for Alzheimer's Disease
Identification of Epigenetic Biomarkers for Alzheimer's Disease in Blood Using Epigenome-wide Analysis
Alzheimer's disease (AD) is a neurodegenerative disorder with no know cure. The pathogenesis of late onset AD (LOAD) is complex and multifactorial in nature, with multiple susceptibility genes and environmental factors at interplay.
The objective of this study is to improve our understanding of the risk factors of LOAD by conducting an epigenome wide study within patients of LOAD contrasted against their cognitively normal siblings.
Study Overview
Status
Conditions
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Timothy Kwok, MD
- Phone Number: 35053145
- Email: tkwok@cuhk.edu.hk
Study Contact Backup
- Name: Joanna Cheng
- Phone Number: 35053990
- Email: chengoiyue@cuhk.edu.hk
Study Locations
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-
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Hong Kong, Hong Kong
- Recruiting
- The Chinese University of Hong Kong
-
Contact:
- Timothy Kwok
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Sub-Investigator:
- Nancy IP, MD
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Sufficient Cantonese competency for cognitive test
- Written informed consent given
- Have at least one gender-matched cognitively normal sibling
Exclusion Criteria:
- Subjects who refuse blood taking procedure
- Do not have a reliable family/caregiver informant (personal contact at least once a month)
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Cross-Sectional
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
DNA methylation
Time Frame: 5 years
|
5 years
|
RNA-seq microbiome
Time Frame: 5 years
|
5 years
|
Alzheimer's disease Assessment Scale-cognitive subscale (Adas-Cog)
Time Frame: 5 years
|
5 years
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Timothy Kwok, Chinese University of Hong Kong
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2018.441
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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