Chinese Research Group of Gallbladder Cancer (CRGGC)

The Chinese Research Group of Gallbladder Cancer (CRGGC) is a retrospective multicenter registry cohort, collecting electronic medical records of patients diagnosed with gallbladder cancer from hospitals in collaboration.

Study Overview

• Status: Recruiting
• Conditions: Gallbladder Neoplasms

Detailed Description

The objectives of the CRGGC are as follows:

1. To study the current diagnosis and treatment of gallbladder cancer in China.
2. To clarify the prognostic role of debated risk factors associated with gallbladder cancer.
3. To improve the accurate staging of gallbladder cancer.
4. To standardize the treatment with gallbladder cancer.

• Study Type: Observational
• Enrollment (Anticipated): 10000

Contacts and Locations

• Study Contact: Name: Yingbin Liu, MD, PhD; Phone Number: +8613918803900; Email: laoniulyb@163.com

Study Locations

• China
  • Anhui
    • Bengbu, Anhui, China, 233004
      • Recruiting
      • The First affiliated hospital of bengbu medical college
      • Contact: Jianguang Jia, MD
    • Hefei, Anhui, China, 230022
      • Recruiting
      • The First Affiliated Hospital of Anhui Medical University
      • Contact: Yeben Qian, MD
    • Hefei, Anhui, China, 230001
      • Recruiting
      • Anhui Provincial Hospital
      • Contact: Lianxin Liu, MD
  • Heilongjiang
    • Harbin, Heilongjiang, China, 150081
      • Recruiting
      • Harbin Medical University Cancer Hospital
      • Contact: Bing Li, 150081
    • Harbin, Heilongjiang, China, 150086
      • Recruiting
      • The Second Affiliated Hospital of Harbin Medical University
      • Contact: Yunfu Cui, MD
    • Harbin, Heilongjiang, China, 150009
      • Recruiting
      • The First Affiliated Hospital Of Harbin Medical University
      • Contact: Bei Sun, MD
  • Henan
    • Zhengzhou, Henan, China, 450052
      • Recruiting
      • The fifth Affiliated Hospital of Zhengzhou University
      • Contact: Xiaoyong Li, MD
    • Zhengzhou, Henan, China, 450003
      • Recruiting
      • Henan Cancer Hospital
      • Contact: Yawei Hua, MD
  • Hunan
    • Changsha, Hunan, China, 410001
      • Recruiting
      • People's Hospital of Hunan Province
      • Contact: Changjun Liu, MD
  • Inner Mongolia
    • Baotou, Inner Mongolia, China, 014040
      • Recruiting
      • Baotou City Central Hospital
      • Contact: Mingzhang Li, MD
  • Jiangsu
    • Changshu, Jiangsu, China, 215500
      • Recruiting
      • Changshu No.1 People's Hospital
      • Contact: Jianfeng Gu, MD
    • Changzhou, Jiangsu, China, 213003
      • Recruiting
      • Changzhou No.2 People's Hospital
      • Contact: Chunfu Zhu, MD
    • Nanjing, Jiangsu, China, 210008
      • Recruiting
      • Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
      • Contact: Yudong Qiu, MD
    • Nantong, Jiangsu, China, 226001
      • Recruiting
      • The First People's Hospital of Nantong
      • Contact: Hong Zang, MD
    • Nantong, Jiangsu, China, 226021
      • Recruiting
      • Affiliated Hospital of Nantong University
      • Contact: Peng Wang, MD
    • Nantong, Jiangsu, China, 226361
      • Recruiting
      • Nantong Tumor Hospital
      • Contact: Hongyu Cai, MD
    • Suzhou, Jiangsu, China, 215004
      • Recruiting
      • The Second Affiliated Hospital of Suzhou University
      • Contact: Xiaoming Ma, MD
    • Taicang, Jiangsu, China, 215400
      • Recruiting
      • The First People's Hospital of Taicang
      • Contact: Yi Wang, MD
    • Wuxi, Jiangsu, China, 214002
      • Recruiting
      • Wuxi Second People's Hospital
      • Contact: Lei Wang, MD
    • Xuzhou, Jiangsu, China, 221006
      • Recruiting
      • The Affiliated Hospital Of XuZhou Medical University
      • Contact: Jian Hong, MD
    • Xuzhou, Jiangsu, China, 221009
      • Recruiting
      • XuZhou Central Hospital
      • Contact: Yuzhen Xu, MD
  • Jiangxi
    • Nanchang, Jiangxi, China, 330006
      • Recruiting
      • Jiangxi Provincial People's Hospital
      • Contact: Xiaoliang Chen, MD
    • Nanchang, Jiangxi, China, 330008
      • Recruiting
      • The Second Affiliated Hospital Of NanChang University
      • Contact: Lu Fang, MD
    • Nanchang, Jiangxi, China, 330019
      • Recruiting
      • The First Affiliated Hospital Of NanChang University
      • Contact: Linhui Zheng, MD
  • Jilin
    • Changchun, Jilin, China, 130021
      • Recruiting
      • The First Bethune Hospital of Jilin University
      • Contact: Yajun Geng, MD
    • Changchun, Jilin, China, 130041
      • Recruiting
      • The Second Hospital of Jilin University
      • Contact: Xuewen Zhang, MD
    • Changchun, Jilin, China, 130033
      • Recruiting
      • China-Japan Union Hospital of Jilin University
      • Contact: Hong Cao, MD
  • Lanzhou
    • Gansu, Lanzhou, China, 730000
      • Recruiting
      • The First Hospital of Lanzhou University
      • Contact: Xun Li, MD
  • Liaoning
    • Shenyang, Liaoning, China, 110004
      • Recruiting
      • ShengJing Hospital Of China Medical University
      • Contact: Chaoliu Dai, MD
  • Qinghai
    • Xining, Qinghai, China, 810007
      • Recruiting
      • Qinghai Provincial People's Hospital
      • Contact: Haihong Zhu, MD
  • Shaanxi
    • Xi'an, Shaanxi, China, 710061
      • Recruiting
      • The First Affiliated Hospital of Xi'an Jiaotong University
      • Contact: Chang Liu, MD
  • Shanghai
    • Shanghai, Shanghai, China, 200092
      • Recruiting
      • Xinhua Hospital
    • Shanghai, Shanghai, China, 200032
      • Recruiting
      • Zhongshan hospital
    • Shanghai, Shanghai, China, 200080
      • Recruiting
      • Shanghai General Hospital
      • Contact: Junmin Xu, MD
    • Shanghai, Shanghai, China, 200438
      • Recruiting
      • Eastern Hepatobiliary Surgery Hospital
      • Contact: Xiaoqing Jiang
    • Shanghai, Shanghai, China, 200062
      • Recruiting
      • Putuo District People's Hospital of Shanghai
      • Contact: Jiahua Yang, MD
    • Shanghai, Shanghai, China, 201100
      • Recruiting
      • Central Hospital of Minhang District
      • Contact: Longhua Rao, MD
    • Shanghai, Shanghai, China, 201399
      • Recruiting
      • Shanghai Pudong Hospital
      • Contact: Xiaoping Yang, MD
    • Shanghai, Shanghai, China, 201499
      • Recruiting
      • Shanghai Fengxian District Central Hospital
      • Contact: Xueli Zhang, MD
    • Shanghai, Shanghai, China, 202150
      • Recruiting
      • Xinhua (Chongming) Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
      • Contact: Zhewei Fei, MD
  • Shanxi
    • Changzhi, Shanxi, China, 046000
      • Recruiting
      • Heping Hospital Affiliated to Changzhi Medical College
      • Contact: Buqiang Wu, MD
    • Taiyuan, Shanxi, China, 030001
      • Recruiting
      • First Hospital Of ShanXi Medical University
      • Contact: Jiansheng Liu, MD
    • Taiyuan, Shanxi, China, 030013
      • Recruiting
      • Shanxi Provincial Cancer Hospital
      • Contact: Xueyi Dang, MD
  • Tianjin
    • Tianjin, Tianjin, China, 300060
      • Recruiting
      • Tianjin Medical University Cancer Hospital
      • Contact: Jihui Hao, MD
  • Xinjiang
    • Ürümqi, Xinjiang, China, 830054
      • Recruiting
      • The First Affiliated Hospital of Xinjiang Medical University
      • Contact: Wei Han, MD
  • Yunnan
    • Kunming, Yunnan, China, 650031
      • Recruiting
      • The First Affiliated Hospital of Kunming Medical University
      • Contact: Kunhua Wang, MD
  • Zhejiang
    • Hangzhou, Zhejiang, China, 310022
      • Recruiting
      • Zhejiang Cancer hospital
    • Hangzhou, Zhejiang, China, 310009
      • Recruiting
      • The Second Affiliated Hospital of Zhejiang University School of Medicine
      • Contact: Jinhui Zhu, MD
    • Hangzhou, Zhejiang, China, 310020
      • Recruiting
      • Sir Run Run Shaw Hospital
      • Contact: Defei Hong, MD
    • Huzhou, Zhejiang, China, 313000
      • Recruiting
      • Huzhou Central Hospital
      • Contact: Weilong Cai, MD
    • Ningbo, Zhejiang, China, 315010
      • Recruiting
      • Ningbo First Hospital
      • Contact: Zhiping Zhang, MD
    • Ningbo, Zhejiang, China, 315040
      • Recruiting
      • Yinzhou Hospital Affiliated to Medical School of Ningbo University
      • Contact: Kejun Hua, MD
    • Shaoxing, Zhejiang, China, 312000
      • Recruiting
      • Shaoxing People's Hospital
      • Contact: Feng Tao, MD
    • Shaoxing, Zhejiang, China, 312000
      • Recruiting
      • Shaoxing Second Hospital
      • Contact: Zaiyang Zhang, MD
    • Wenzhou, Zhejiang, China, 325015
      • Recruiting
      • The First Affiliated Hospital of Wenzhou Medical University
      • Contact: Mengtao Zhou, MD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients from 2008 to 2020 diagnosed with gallbladder cancer in collaborated hospitals in China.

Description

Inclusion Criteria:

• Patients with at least clinical diagnosis of gallbladder cancer, including C23.9 and part of C24.0 (cystic duct cancer).
• Patients with accessible electronic medical record

Exclusion Criteria:

• Patients with undetermined primary site of cancer.

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Cross-Sectional

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Overall Survival	The overall survival data were defined by (date of death) - (date of first diagnosis). The survival status of patients were retrieved from follow-up.	5 years

Collaborators and Investigators

• Sponsor: Shanghai Jiao Tong University School of Medicine
• Collaborators: Tianjin Medical University Cancer Hospital; Zhejiang Cancer Hospital; Xijing Hospital; The First Affiliated Hospital of Anhui Medical University; The First Affiliated Hospital of Nanchang University; LanZhou University; Shanghai Zhongshan Hospital; Henan Cancer Hospital; Qilu Hospital of Shandong University; Second Affiliated Hospital, School of Medicine, Zhejiang University; Shengjing Hospital; First Affiliated Hospital Xi'an Jiaotong University; The Affiliated Hospital of Qingdao University; The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School; Shandong Provincial Hospital; The First Affiliated Hospital of Zhengzhou University; Jiangxi Provincial Cancer Hospital; Shanxi Provincial Cancer Hospital; The First Hospital of Jilin University; Eastern Hepatobiliary Surgery Hospital; Xuzhou Central Hospital; Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; The First Affiliated Hospital of Kunming Medical College; Sir Run Run Shaw Hospital; First Affiliated Hospital of Wenzhou Medical University; Shaoxing People's Hospital; The Second Affiliated Hospital of Harbin Medical University; Qinghai People's Hospital; The First Affiliated Hospital of Shanxi Medical University; Shaoxing Second Hospital; First Affiliated Hospital of Xinjiang Medical University; Ningbo No. 1 Hospital; Huizhou Municipal Central Hospital; First Affiliated Hospital Bengbu Medical College; Second Affiliated Hospital of Nanchang University; Harbin Medical University; Changzhi Medical College; Second Hospital of Jilin University; The Affiliated Hospital of Xuzhou Medical University; China-Japan Union Hospital, Jilin University; First Affiliated Hospital of Harbin Medical University; Anhui Provincial Hospital; Shanghai Pudong Hospital; Second Affiliated Hospital of Suzhou University; The First People's Hospital of Changzhou; Hainan People's Hospital; Affiliated Hospital of Nantong University; Jiangxi Provincial People's Hopital; Changzhou No.2 People's Hospital; The Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu Province, China; The First People's Hospital of Taicang; Wuxi Second People's Hospital; The First People's Hospital of Nantong; Baotou Central Hospital; Shanghai Fengxian District Central Hospital; Central Hospital of Minhang District, Shanghai; Putuo District People's Hospital of Shanghai; Xinhua (Chongming) Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Yinzhou Hospital Affiliated to Medical School of Ningbo University; People's Hospital of Hunan Province; Taizhou Municipal Hospital; Xinghua City People's Hospital; Tongliao City Hospital
• Investigators: Principal Investigator: Yingbin Liu, MD, PhD, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Publications and helpful links

General Publications

• Li L, Ren T, Liu K, Li ML, Geng YJ, Yang Y, Li HF, Li XC, Bao RF, Shu YJ, Weng H, Gong W, Lau WY, Wu XS, Liu YB. Development and Validation of a Prognostic Nomogram Based on the Systemic Immune-Inflammation Index for Resectable Gallbladder Cancer to Predict Survival and Chemotherapy Benefit. Front Oncol. 2021 Jun 29;11:692647. doi: 10.3389/fonc.2021.692647. eCollection 2021.
• Ren T, Li Y, Zhang X, Geng Y, Shao Z, Li M, Wu X, Wang XA, Liu F, Wu W, Shu Y, Bao R, Gong W, Dong P, Dang X, Liu C, Liu C, Sun B, Liu J, Wang L, Hong D, Qin R, Jiang X, Zhang X, Xu J, Jia J, Yang B, Li B, Dai C, Cao J, Cao H, Tao F, Zhang Z, Wang Y, Jin H, Cai H, Fei Z, Gu J, Han W, Feng X, Fang L, Zheng L, Zhu C, Wang K, Zhang X, Li X, Jin C, Qian Y, Cui Y, Xu Y, Wang X, Liu H, Hua Y, Liu C, Hao J, Wang C, Li Q, Li X, Liu J, Li M, Qiu Y, Wu B, Zheng J, Chen X, Zhu H, Hua K, Yan M, Wang P, Zang H, Ma X, Hong J, Liu Y. Protocol for a gallbladder cancer registry study in China: the Chinese Research Group of Gallbladder Cancer (CRGGC) study. BMJ Open. 2021 Feb 16;11(2):e038634. doi: 10.1136/bmjopen-2020-038634.

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2008
• Primary Completion (Anticipated): December 31, 2022
• Study Completion (Anticipated): December 31, 2025

Study Registration Dates

• First Submitted: October 24, 2019
• First Submitted That Met QC Criteria: October 24, 2019
• First Posted (Actual): October 28, 2019

Study Record Updates

• Last Update Posted (Actual): June 30, 2021
• Last Update Submitted That Met QC Criteria: June 29, 2021
• Last Verified: June 1, 2021

More Information

Terms related to this study

• Keywords: gallbladder cancer; gallbladder neoplasms
• Additional Relevant MeSH Terms: Digestive System Diseases; Neoplasms; Neoplasms by Site; Digestive System Neoplasms; Gallbladder Diseases; Biliary Tract Diseases; Biliary Tract Neoplasms; Gallbladder Neoplasms
• Other Study ID Numbers: CRGGC_LYB_2019

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No
• IPD Plan Description: No plan for IPD access is scheduled.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No