Selatogrel Outcome Study in Suspected Acute Myocardial Infarction (SOS-AMI)

Multi-center, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of Self-administered Subcutaneous Selatogrel for Prevention of All-cause Death and Treatment of Acute Myocardial Infarction in Subjects With a Recent History of Acute Myocardial Infarction

This study will randomize patients recently discharged from the hospital with a confirmed diagnosis of type 1 acute myocardial infarction (Thygesen et al. 2018) and having additional cardiovascular risk factors.

Study Overview

• Status: Enrolling by invitation
• Conditions: Acute Myocardial Infarction
• Intervention / Treatment: Combination product: Selatogrel; Combination product: Placebo

Detailed Description

The purpose of this study is to assess the clinical efficacy of selatogrel when self-administered upon occurrence of symptoms suggestive of an acute myocardial infarction (AMI) in participants at risk of having a recurrent AMI.

• Study Type: Interventional
• Enrollment (Estimated): 25000
• Phase: Phase 3

Contacts and Locations

Study Locations

• Australia
  • Adelaide, Australia, 5000
    • Royal Adelaide Hospital/ CNARTS
  • Ballarat, Australia, 3350
    • Grampians Health
  • Chermside, Australia, 4032
    • The Prince Charles Hospital
  • Clayton, Australia, 3168
    • Monash Health
  • Concord, Australia, 2139
    • Concord Repatriation General Hospital (CRGH) (Concord Hospital)
  • Epping, Australia, 3076
    • The Cardiologists Pty. Ltd
  • Garran, Australia, 2605
    • The Canberra Hospital
  • Gosford, Australia, 2250
    • Gosford Hospital
  • Hobart, Australia, 7000
    • Tasmanian Health at Royal Hobart Hospital
  • Melbourne, Australia, 3004
    • The Alfred Hospital
  • Melbourne, Australia, 3050
    • The Royal Melbourne Hospitals
  • St Albans, Australia, 3021
    • Western Health - Sunshine Hospital
  • Wollongong, Australia, 2500
    • Wollongong Hospital - Illawarra Shoalhaven Local Health District
  • Woodville South, Australia, 5011
    • The Queen Elizabeth Hospital
• Austria
  • Graz, Austria, 8036
    • LKH Universitätsklinikum Graz
  • Klagenfurt, Austria, 9020
    • Klinikum Klagenfurt am Woerthersse
  • Sankt Pölten, Austria, 3100
    • Universitätsklinikum St. Pölten
  • Vienna, Austria, 1160
    • Klinik Ottakring
  • Vienna, Austria, 1210
    • Karl Landsteiner Institut für Kardiovaskuläre und Intensivmedizinische Forschung
• Belgium
  • Aalst, Belgium, 9300
    • OLV Aalst
  • Genk, Belgium, 3600
    • Hospital Oost-Limburg (ZOL)
  • Ghent, Belgium, 9000
    • AZ Sint-Lucas
  • Leuven, Belgium, 3000
    • University Hospital Leuven (UZ Leuven)
  • Roeselare, Belgium, 8800
    • AZ Delta Campus Rumbeke
• Brazil
  • Barretos, Brazil, 14784-400
    • Hospital de Amor Barretos - Fundação PIO XII
  • Belo Horizonte, Brazil, 30150-221
    • Santa Casa de Misericórdia de Belo Horizonte
  • Belo Horizonte, Brazil, 30150-274
    • CARDRESEARCH - Cardiologia Assistencial e de Pesquisa
  • Campina Grande do Sul, Brazil, 83430-000
    • Sociedade Hospitalar Angelina Caron
  • Campinas, Brazil, 13060-080
    • IPECC - Instituto de Pesquisa Clinica de Campinas
  • Campo Grande, Brazil, 79080-190
    • Hospital Universitario Maria Aparecida Pedrossian
  • Juiz de Fora, Brazil, 36033-318
    • Galileo Medical Research Ltda
  • Porto Alegre, Brazil, 90050-170
    • Irmandade da Santa Casa de Misericordia de Porto Alegre
  • Porto Alegre, Brazil, 90160-093
    • Hospital Ernesto Dornelles
  • Porto Alegre, Brazil, 90620001
    • Instituto de Cardiologia do Rio Grande do Sul/ Fundação Universitária de Cardiologia
  • Porto Alegre, Brazil, 90840-440
    • CoraCentro Pesquisa Clinica
  • Porto Alegre, Brazil, 91350-280
    • Hospital Nossa Senhora da Conceição / FZ Cardiologia
  • Rio de Janeiro, Brazil, 22.280-020
    • Esho Empresa de Serviços Hospitalares- HOSPITAL PRÓ CARDIACO
  • Salvador, Brazil, 40050-410
    • Hospital Santa Izabel - Santa Casa de Misericórdia da Bahia
  • Salvador, Brazil, 40.323-010
    • Hospital e Maternidade Anna Nery
  • São Paulo, Brazil, 05403-000
    • Instituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo
  • São Paulo, Brazil, 01409-902
    • Hospital Nove de Julho - Ímpar Serviços Hospitalares S.A
  • Uberlândia, Brazil, 38402-028
    • Ebserh Hospital de Clínicas da Universidade Federal de Uberlândia-HC-UFU
• Bulgaria
  • Blagoevgrad, Bulgaria, 2700
    • Mbal Puls
  • Burgas, Bulgaria, 8127
    • UMHAT Deva Maria
  • Burgas, Bulgaria, 8000
    • MHAT Heart and Brain - Burgas
  • Gabrovo, Bulgaria, 5300
    • MHAT "Dr. Tota Venkova", AD
  • Gotse Delchev, Bulgaria, 2900
    • MHAT Ivan Skenderov EOOD
  • Kardzhali, Bulgaria, 6600
    • Medical Centre Avitzena
  • Lovech, Bulgaria, 5500
    • MHAT Cardiolife OOD
  • Panagyurishte, Bulgaria, 4500
    • MHAT Uni Hospital
  • Pernik, Bulgaria, 2300
    • SHATC Sveti Georgi
  • Pleven, Bulgaria, 5800
    • UMHAT 'Dr. Georgi Stranski', EAD
  • Pleven, Bulgaria, 5800
    • MHAT Heart and Brain - Pleven
  • Plovdiv, Bulgaria, 4003
    • UMHAT-Plovdiv AD
  • Plovdiv, Bulgaria, 4002
    • UMHAT "Sv. Georgi", EAD
  • Plovdiv, Bulgaria, 4004
    • MHAT "Sv. Karidad", EAD
  • Plovdiv, Bulgaria, 4003
    • Medical Center Sveti Ivan Rilski Chudotvorets-2010" EOOD
  • Sandanski, Bulgaria, 2802
    • MHAT South-West Hospital, Cardiology Department
  • Sofia, Bulgaria, 1202
    • Second MHAT - Sofia AD
  • Sofia, Bulgaria, 1431
    • UMHAT "Alexandrovska" EAD
  • Sofia, Bulgaria, 1606
    • UMHATEM N I Pirogov EAD
  • Sofia, Bulgaria, 1407
    • MHAT "Lozenets"
  • Sofia, Bulgaria, 1431
    • UMHAT "Sveta Ekaterina"
  • Stara Zagora, Bulgaria, 6000
    • UMHAT Prof. Dr. Stoyan Kirkovich AD
  • Stara Zagora, Bulgaria, 6002
    • MHAT-Medical Complex Sveti Ivan Rilski EOOD-branch Stara Zagora
  • Veliko Tarnovo, Bulgaria, 5000
    • MDHAT 'Dr. Stefan Cherkezov', AD
  • Yambol, Bulgaria, 8600
    • MHAT "Sv. Panteleymon" - Yambol, AD
• Canada
  • Montreal, Canada, H4J 1C5
    • Hopital Du Sacre-Coeur de Montreal
  • Ottawa, Canada, K1Y 4W7
    • University of Ottawa Heart Institute
  • Trois-Rivières, Canada, G9A 4P3
    • Diex Research, Inc.
  • Winnipeg, Canada, R2H 2A6
    • St. Boniface Hospital
  • Alberta
    • Calgary, Alberta, Canada, T2N 4Z6
      • University of Calgary Foothills Medical Centre
    • Edmonton, Alberta, Canada, T6G 2B7
      • University of Alberta Hospital
    • Edmonton, Alberta, Canada, T5H 3V9
      • Royal Alexandra Hospital
    • Edmonton, Alberta, Canada, T6L 5X8
      • Grey Nuns Community Hospital
  • Nova Scotia
    • Halifax, Nova Scotia, Canada, B3H3A7
      • Queen Elizabeth II Health Sciences Centre
  • Ontario
    • Brampton, Ontario, Canada, L6R 3J7
      • Wiliam Osler Health System
    • Cambridge, Ontario, Canada, N1R 6V6
      • Cambridge Cardiac Care Center
    • Newmarket, Ontario, Canada, L3Y 2P7
      • York PCI Group, Inc.
    • Peterborough, Ontario, Canada, K9J 0B2
      • Kawartha Cardiology Clinical Trials
    • Toronto, Ontario, Canada, M5B1W8
      • St. Michael's Hospital
  • Quebec
    • Lévis, Quebec, Canada, G6V 4Z5
      • Clinique de Cardiologie de Lévis
    • Montreal, Quebec, Canada, H1T 1C8
      • Montreal Heart Institute
    • Montreal, Quebec, Canada, H4J1C5
      • Hopital Du Sacre-Coeur de Montreal
    • Montreal, Quebec, Canada, H2X 0A9
      • CHUM - Centre hospitalier de l'Universite de Montreal"
    • Trois-Rivières, Quebec, Canada, G9A 5C5
      • Centre Intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec
• Chile
  • Santiago, Chile, 7500000
    • Cec-Suecia
  • Santiago, Chile, 8330034
    • Pontificia Universidad Catolica de Chile
  • Santiago, Chile, 8380465
    • Clinica Ensenada
  • Victoria, Chile, 4720000
    • Hospital San Jose de Victoria
• China
  • Baotou, China, 14040
    • Baotou Central Hospital
  • Beijing, China, 100029
    • Beijing AnZhen Hospital, Capital Medical University
  • Beijing, China, 101200
    • Beijing Pinggu Hospital
  • Beijing, China, 101199
    • Beijing Luhe Hospital, Capital Medical University
  • Cangzhou, China, 061001
    • Cangzhou Central Hospital
  • Changchun, China, 130041
    • The Second Hospital of Jilin University
  • Changchun, China, 130021
    • The First Bethune Hospital of Jilin University
  • Changsha, China, 410013
    • The Third Xiangya Hospital of Central South University
  • Changsha, China, 410008
    • Xiangya Hospital Central South University
  • Changsha, China, 410012
    • The Second Xiangya Hospital of Central South University
  • Chengdu, China, 610017
    • Chengdu Second People's Hospital
  • Chengdu, China, 610044
    • West China Hospital of Sichuan University
  • Chongqing, China, 400016
    • The First Affiliated Hospital of Chongqing Medical University
  • Dalian, China, 116027
    • The Second Hospital of Dalian Medical University
  • Daqing, China, 163001
    • Daqing Oilfield General Hospital
  • Datong, China, 37001
    • Sinopharm Coal General Hospital
  • Dongcheng, China, 100730
    • Beijing Hospital
  • Dongguan, China, 523059
    • Dongguan People's Hospital
  • Dongying, China, 257091
    • Dongying People's Hospital
  • Fuzhou, China, 350013
    • Fujian Provincial Hospital
  • Gaozhou, China, 525299
    • Gaozhou People 's Hospital
  • Guangdong, China, 515041
    • The First Affiliated Hospital of Shantou University Medical College
  • Guangzhou, China, 510080
    • Guangdong Provincial People's Hospital
  • Guangzhou, China, 510000
    • Sun Yat-sen Memorial Hospital, Sun Yat-sen University
  • Hangzhou, China, 310013
    • Zhejiang Hospital
  • Hangzhou, China, 310003
    • The First Affiliated Hospital, Zhejiang University School of Medicine
  • Hangzhou, China, 310016
    • Sir Run Run Shaw Hospital (SRRSH), affiliated with the Zhejiang University School of Medicine
  • Hangzhou, China, 310050
    • The Second Affiliated Hospital of Zhejiang University School of Medicine
  • Hangzhou, China, 310014
    • Zhejiang Provincial Peoples Hospital
  • Harbin, China, 150036
    • Heilongjiang Provincial Hospital
  • Harbin, China, 150001
    • The First Affiliated Hospital of Harbin Medical University
  • Hefei, China, 230001
    • The First Affiliated Hospital of USTC(Anhui Provincial Hospital)
  • Jiaozuo, China, 454800
    • Jiaozuo People's Hospital
  • Jieyang, China, 522000
    • Jieyang People's Hospital
  • Jinan, China, 250013
    • Jinan Central Hospital
  • Jinan, China, 250033
    • The Second Hospital of Shandong University
  • Jinan, China, 250011
    • Shandong University Qilu Hospital
  • Jinan, China, 250014
    • The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital)
  • Jining, China, 272073
    • Jining No.1 People's Hospital
  • Kunming, China, 650051
    • Yan'an Hospital Affiliated to Kunming Medical University
  • Lanzhou, China, 730000
    • Gansu Provincial Hospital
  • Lianyungang, China, 222002
    • Lianyungang First People's Hospital
  • Liaocheng, China, 252000
    • Liaocheng People's Hospital
  • Linyi, China, 276007
    • Linyi people's hospital
  • Liuzhou, China, 545006
    • Liuzhou People's Hospital
  • Luoyang, China, 471003
    • Henan University of Science and Technology (HUST) - The First Affiliated Hospital
  • Nanchang, China, 330006
    • The Second Affiliated Hospital of Nanchang University
  • Nanchong, China, 637000
    • Beijing Anzhen Nanchong Hospital, Capital Medical University & Nanchong Central Hospital
  • Nanjing, China, 210009
    • Zhongda Hospital Southeast University
  • Nanjing, China, 211100
    • Nanjing Jiangning Hospital
  • Nanyang, China, 473000
    • Nanyang Central Hospital
  • Nanyang, China, 473001
    • Nanyang Second People's Hospital
  • Ningbo, China, 315010
    • The First Affiliated Hospital of Ningbo University
  • Ningbo, China, 315040
    • Ningbo Medical Center Lihuili Hospital
  • Pingxiang, China, 337055
    • Pingxiang People's Hospital
  • Qingdao, China, 266011
    • Qingdao Municipal Hospital
  • Rui’an, China, 355250
    • Ruian Peoples Hospital
  • Shanghai, China, 200080
    • Shanghai General Hospital
  • Shanghai, China, 200011
    • Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
  • Shanghai, China, 200127
    • Renji Hospital, Shanghai Jiaotong University School of Medicine
  • Shanghai, China, 200030
    • Shanghai Chest Hospital ,Shanghai Jiao Tong University School of Medicine
  • Shanghai, China, 201800
    • Shanghai Jiading Central Hospital
  • Shanghai, China, 200072
    • Shanghai Tenth People 's Hospital
  • Shanghai, China, 200120
    • Shanghai East Hospital (Tongji University East Hospital)
  • Shaoguan, China, 512026
    • Yuebei People's Hospital
  • Shaoxing, China, 311899
    • Zhuji People's Hospital
  • Shenyang, China, 110067
    • The People's Hospital of Liaoning Province
  • Shenyang, China, 110000
    • The fourth Affiliated Hospital of China Medical University
  • Shijiazhuang, China, 050031
    • The First Hospital of Hebei Medical University
  • Shijiazhuang, China, 50011
    • The Second Hospital of Hebei Medical University
  • Shijiazhuang, China, 50000
    • The Third Hospital of Shijiazhuang
  • Suzhou, China, 215000
    • The Fourth Affiliated Hospital of Soochow University
  • Suzhou, China, 215006
    • The first Affiliated Hospital of Soochow
  • Taiyuan, China, 30024
    • Shanxi Cardiovascular Hospital
  • Tangshan, China, 63000
    • Tangshan Central Hospital
  • Tianjin, China, 300052
    • Tianjin Medical University General Hospital
  • Tianjin, China, 300457
    • Teda International Cardiovascular Hospital
  • Tianjin, China, 300222
    • Tianjin Chest Hospital
  • Tianjin, China, 300142
    • Tianjin Fourth Central Hospital
  • Wenzhou, China, 325000
    • Wenzhou People's Hospital
  • Wenzhou, China, 325000
    • Wenzhou Medical University (WMU) - The First Affiliated Hospital
  • Wuhan, China, 430014
    • The Central Hospital of Wuhan
  • Wuhan, China, 430022
    • Wuhan Asia Heart Hospital
  • Wuhan, China, 430060
    • Renmin Hospital of Wuhan University
  • Wuxi, China, 214023
    • The People's Hospital of Wuxi
  • Xi'an, China, 710061
    • The First Affiliated Hospital of Xi'an Jiaotong University
  • Xi'an, China, 710114
    • The Second Affiliated Hospital of Xi'an Jiaotong University
  • Xinjiang, China, 830011
    • The First Affiliated Hospital of Xinjiang Medical University
  • Xinxiang, China, 453001
    • Xinxiang Central Hospital
  • Xuzhou, China, 221004
    • Xuzhou Medical University Affiliated Hospital
  • Yangzhou, China, 225000
    • Northern Jiangsu People's Hospital
  • Yanji, China, 133099
    • Yanbian University Affiliated Hospital
  • Yinchuan, China, 750003
    • General Hospital of Ningxia Medical University
  • Yiyang, China, 413000
    • Yiyang Central Hospital
  • Zhanjiang, China, 524001
    • Affiliated Hospital of Guangdong Medical University
  • Zhanjiang, China, 524045
    • Zhanjiang Central People 's Hospital
  • Zhengzhou, China, 450052
    • the First Affiliated Hospital of Zhengzhou University
  • Zhengzhou, China, 450016
    • The 7th People's Hospital of Zhengzhou
  • Zibo, China, 255036
    • Zibo Central Hospital
• Czechia
  • Brno, Czechia, 62500
    • University Hospital Brno
  • Brno, Czechia, 60200
    • ICRC St. Anne University Hospital
  • Bruntál, Czechia, 79201
    • Kardiologie Bruntál CorMedico s.r.o
  • Hradec Králové, Czechia, 50005
    • University hospital Hradec Králové
  • Jihlava, Czechia, 586 01
    • Regional Hospital Jihlava
  • Liberec, Czechia, 46063
    • Regional Hospital Liberec
  • Ostrava - Poruba, Czechia, 708 00
    • KARDIOKRI s.r.o
  • Pardubice, Czechia, 53203
    • Nemocnice Pardubickeho kraje, a.s. - Pardubicka nemocnice
  • Pilsen, Czechia, 30460
    • Fakultni Nemocnice Plzen
  • Prague, Czechia, 10034
    • Univ. Hospital Vinohrady
  • Prague, Czechia, 140 21
    • Institutu Klinicke a Experimentalni Mediciny (IKEM) (Institute for Clinical and Experimental Medicine)
  • Prague, Czechia, 12808
    • Vseobecna Fakultni Nemocnice
  • Prague, Czechia, 10100
    • Kardiologie Praha s.r.o.
  • Prague, Czechia, 12000
    • General Faculty Hospital
  • Praha 1 - Nové Mesto, Czechia, 11000
    • Kardiologie Vinohrady s.r.o.
  • Prostějov, Czechia, 79601
    • Olomuc Cardiology
  • Ústí nad Labem, Czechia, 40013
    • University Hospital Ústí nad Labem
  • České Budějovice, Czechia, 37001
    • Regional Hospital Ceské Budejovice
• Denmark
  • Aarhus, Denmark, 8200
    • Aarhus University Hospital
  • Esbjerg, Denmark, 6700
    • Esbjerg Hospital
  • Gistrup, Denmark, 9260
    • Aalborg University Hospital Cardiology
  • Hellerup, Denmark, 2900
    • Rigshospitalet
  • Herning, Denmark, 7400
    • Herning Hospital
  • Herning, Denmark, 7400
    • Goedstrup Region Hospital
  • Odense, Denmark, 5000
    • Odense Universitetshospital
  • Roskilde, Denmark, 4000
    • Zealand University Hospital
  • Svendborg, Denmark, 5700
    • Svendborg Hospital
  • Viborg, Denmark, 8800
    • Viborg Hospital
• Estonia
  • Tallinn, Estonia, 13419
    • The North Estonia Medical Centre
  • Tartu, Estonia, 50406
    • Heart Clinic, Tartu University Hospital
• Finland
  • Espoo, Finland, 02740
    • Jorvi Hospital, Helsinki University Hospital
  • Helsinki, Finland, 00290
    • Heart and Lung Center, Helsinki University Hospital
  • Joensuu, Finland, 80210
    • North Karelian Central Hospital
  • Jyväskylä, Finland, 40620
    • StudyCor
  • Kokkola, Finland, 67200
    • Kokkola Central Hospital
  • Kuopio, Finland, 70210
    • Kuopio University Hospital
  • Oulu, Finland, 90220
    • Oulu University Hospital
  • Seinäjoki, Finland, 60220
    • Seinäjoki Central Hospital
  • Tampere, Finland, 335200
    • TAYS Tutkimusvastaanotto / TAYS Research Center
  • Tampere, Finland, 33520
    • TAYS Sydänkeskus Oy (Heart Hospital Tampere University Hospital)
  • Turku, Finland, 20520
    • Heart Center, Turku University Hospital
• France
  • Brest, France, 29200
    • CHRU Brest - Cavale Blanche
  • Caen, France, 14033
    • CHU Caen · Unité Cardiologie et Pathologie Vasculaire
  • La Roche-sur-Yon, France, 85925
    • Hospital Center Departmental Vendée
  • Le Coudray, France, 28630
    • CH Chartres
  • Marseille, France, 13005
    • CHU Timone 2
  • Montpellier, France, 34295
    • Hopital Arnaud de Villeneuve
  • Montpellier, France, 34680
    • Clinique du Millénaire
  • Nîmes, France, 30000
    • Univ Hosp de Nimes Carémeau
  • Paris, France, 75013
    • University Hospitals Pitié Salpêtrière
  • Paris, France, 75018
    • Bichat-Claude Bernard Hospital
  • Toulouse, France, 31059
    • Hosp Rangueil - Cardiology A Dept
  • Vandœuvre-lès-Nancy, France, 54500
    • CHRU Nancy
  • Gironde
    • Pessac, Gironde, France, 33604
      • Hopital Cardiologique CHU Bordeaux
• Georgia
  • Batumi, Georgia, 6000
    • LTD High Technology Hospital Medcenter
  • Gurjaani, Georgia, 1500
    • LLC " Geo Hospitals"
  • Kutaisi, Georgia, 4600
    • LTD West Georgia Medical Center
  • Kutaisi, Georgia, 4600
    • LTD"West Regional Center of the Modern Medical Technologies
  • Tbilisi, Georgia, 159
    • Acad. G. Chapidze Emergency Cardiology Center
  • Tbilisi, Georgia, 159
    • Tbilisi Heart and Vascular Clinic Ltd.
  • Tbilisi, Georgia, 160
    • TIM Hospital
  • Tbilisi, Georgia, 186
    • LTD "Tbilisi Heart Center"
  • Tbilisi, Georgia, 137
    • JSC Viani
  • Tbilisi, Georgia, 144
    • LLC Geo Hospitals
  • Tbilisi, Georgia, 144
    • Ltd Cardiology Clinic "Guli"
  • Tbilisi, Georgia, 172
    • Georgian-Dutch hospital
  • Tbilisi, Georgia, 159
    • Bokhua Memorial CardioVascular Center LTD
  • Tbilisi, Georgia, 102
    • Aleksandere Aladashvili Clinic Ltd
• Germany
  • Bad Krozingen, Germany, 79189
    • Universitätsklinikum Freiburg; Universitäts-Herzzentrum Freiburg-Bad Krozingen
  • Bad Oeynhausen, Germany, 32545
    • Herz- und Diabeteszentrum NRW
  • Berlin, Germany, 13585
    • Vivantes Klinikum Spandau
  • Berlin, Germany, 13509
    • Vivantes Netzwerk für Gesundheit GmbH
  • Berlin, Germany, 13347
    • MedicTRials STUG - Praxis Dr. Toursarkissian
  • Bonn, Germany, 53127
    • UKB University Hospital Bonn
  • Cologne, Germany, 50678
    • Krankenhaus der Augustinerinnen Köln gGmbH
  • Dortmund, Germany, 44137
    • St. Johannes Hospital Dortmund
  • Dresden, Germany, 01307
    • Herzzentrum Dresden GmbH; Universitätsklinik an der Technischen Universität Dresden
  • Hamburg, Germany, 20246
    • Universitatsklinikum Hamburg Eppendorf
  • Karlsbad, Germany, 76307
    • SRH Klinikum Karlsbad-Langensteinbach GmbH
  • Leipzig, Germany, 04289
    • Herzzentrum Leipzig GmbH
  • Ludwigshafen, Germany, 67063
    • Gesellschaft für Klinische Forschung mbH Ludwigshafen
  • Magdeburg, Germany, 39120
    • Uniklinikum Magdeburg A. ö. R.
  • Mannheim, Germany, 68167
    • Universitätsmedizin Mannheim
  • München, Germany, 81737
    • München Klinik Neuperlach
  • Regensburg, Germany, 93053
    • Studienzentrum Innere Med. II Kardiologie, Universitätsklinikum Regensburg
  • Stuttgart, Germany, 70376
    • Robert-Bosch Krankenhaus Stuttgart
  • Trier, Germany, 54292
    • Krankenhaus der Barmherzigen Brüder
  • Tübingen, Germany, 72076
    • Universitätsklinikum Tübingen, Medizinische Klinik Innere Medizin III Kardiologie und Angiologie
  • Völklingen, Germany, 66333
    • Siteworks GmbH Prüfzentrum Völklingen
  • Wuppertal, Germany, 42117
    • Helios Universitätsklinikum Wuppertal
• Greece
  • Alexandroupoli, Greece, 68100
    • University General Hospital of Alexandroupolis
  • Athens, Greece, 10676
    • Evaggelismos Hospital
  • Athens, Greece, 11527
    • Laiko General Hospital of Athens
  • Athens, Greece, 11527
    • Ippokrateio (Hyppokration) General Hospital of Athens
  • Athens, Greece, 124 62
    • University General Hospital Attikon General Hospital Of West Attica H Agia Varvara
  • Athens, Greece, 11522
    • General Hospital of Athens "Elpis"
  • Athens, Greece, 14561
    • General Hospital of Athens "KAT"
  • Heraklion, Greece, 71500
    • University Hospital of Heraklion
  • Ioannina, Greece, 454 45
    • G. Hatzsikosta General Hospital of Ioannina
  • Magoula, Greece, 19600
    • Thriasio General Hospital
  • Marousi, Greece, 15123
    • Hygeia Hospital
  • Marousi, Greece, 15126
    • Sismanoglio Hospital of GNA "Sismanoglio - Amalia Fleming
  • Nea Ionia, Greece, 14233
    • Konstantopouleio - Patision General Hospital of Nea Ionia
  • Piraeus, Greece, 18536
    • Tzaneio Hospital
  • Pátrai, Greece, 26504
    • University Hospital of Patras
  • Pátrai, Greece, 263 32
    • General Hospital of Patras '"O Agios Andreas"
  • Thessaloniki, Greece, 54636
    • Aristotle University of Thessaloniki (AUTH) - University General Hospital of Thessaloniki (AHEPA)
  • Thessaloniki, Greece, 57010
    • General Hospital of Thessaloniki G.Papanikolaou
  • Voula, Greece, 16673
    • Asklepeion General Hospital, Voula
• Hungary
  • Baja, Hungary, 6500
    • Euréka-Center Bt.
  • Balatonfüred, Hungary, 8230
    • Állami Szívkorhaz
  • Budapest, Hungary, 1145
    • Uzsoki Utcai Kórház
  • Budapest, Hungary, 1134
    • Magyar Honvédség Egészségügyi Központ
  • Budapest, Hungary, 1023
    • Betegápoló Irgalmasrend Budai Irgalmasrendi Kórház, Kardiológia
  • Budapest, Hungary, 1122
    • Semmelweis Egyetem Városmajori Szív- és Érgyógyászati Klinika Kardiológia
  • Budapest, Hungary, 1106
    • Budapesti Bajcsy-Zsilinszky Hospital
  • Debrecen, Hungary, 4032
    • Debreceni Egyetem Klinikai Központ Kardiológiai és Szívsebészeti Klinika
  • Kecskemét, Hungary, 6000
    • Bács-Kiskun Megyei Kórház a Szegedi Tudományegyetem Általános Orvostudományi Kar Oktató Kórháza
  • Nyíregyháza, Hungary, 4400
    • SzSzBV Egyetemi Oktatókórház, Nyíregyházi Jósa András Tagkórház, Kardiológia
  • Pécs, Hungary, 7624
    • Pécsi Tudományegyetem, ÁOK
  • Pécs, Hungary, 7635
    • DaVinci Maganklinika
  • Szolnok, Hungary, 5000
    • Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház-Rendelőintézet
• India
  • Ahmedabad, India, 380060
    • Care Institute of Medical Sciences
  • Ahmedabad, India, 380025
    • GCS Medical College, Hospital & Research Centre
  • Ahmedabad, India, 380054
    • Epic Hospital
  • Aligarh, India, 202001
    • Jawaharlal Nehru Medical College and Hospital - AMU
  • Aurangabad, India, 431010
    • Kamal Nayan Bajaj Hospital
  • Aurangabad, India, 431003
    • MGM Hospital and Medical College
  • Bangalore, India, 560099
    • Narayana Health - Institute of Cardiac Sciences
  • Bangalore, India, 560069
    • Sri Jayadeva Institute of Cardiology
  • Bathinda, India, 151001
    • All India Institute of Medical Sciences Bathinda
  • Belagavi, India, 590016
    • BHS Lakeview Hospital
  • Belagavi, India, 590010
    • K.L.E. Society's Dr. Prabhakar Kore Hospital and Medical Research Centre
  • Bhubaneswar, India, 751019
    • All India Institute of Medical Sciences
  • Bikaner, India, 334003
    • S. P. Medical College & Associated Group of Hospitals
  • Chennai, India, 600037
    • The Madras Medical Mission
  • Chennai, India, 600116
    • Sri Ramachandra Medical Center
  • Coimbatore, India, 641018
    • K.G. Hospital and PG Medical Institute
  • Dehradun, India, 248011
    • Sgrrih & Ms
  • Delhi, India, 110062
    • Batra Hospital and Medical Research Centre
  • Deralakatte, India, 575018
    • Justice K. S. Hegde Charitable Hospsital
  • Faridabad, India, 121006
    • Sarvodaya Hospital
  • Faridabad, India, 121001
    • ESIC Medical College and Hospital
  • Ghaziabad, India, 201012
    • Max Super Speciality Hospital Vaishali
  • Guntur, India, 522001
    • Lalitha Super Speciality Hospital
  • Hyderabad, India, 500012
    • Osmania General Hospital
  • Hyderabad, India, 500090
    • Sri Sri Holistic Hospitals
  • Hyderabad, India, 500042
    • Malla Reddy Narayana Multispecialty hospital
  • Hyderabad, India, 500034
    • TX Hospitals
  • Hyderabad, India, 500049
    • Pulse Heart Super Speciality Hospital
  • Hyderabad, India, 500081
    • Medicover Hospitals
  • Jaipur, India, 302017
    • Apex Hospital Pvt. Ltd.
  • Kattankulathur, India, 603203
    • SRM Medical College Hospital and Research Centre
  • Kochi, India, 682040
    • Lakeshore Hospital and Research Centre Ltd.
  • Kochi, India, 682041
    • Amrita Institute of Medical Sciences and Research Centre
  • Kochi, India, 682 018
    • Lisie Hospital
  • Kolhāpur, India, 416008
    • Sri Sai Cardiac Centre Unit of Mahalaxmi Hrudayalaya Pvt. Ltd
  • Kolkata, India, 700020
    • IPGMER and SSKM Hospital
  • Kozhikode, India, 673008
    • Government Medical College
  • Kurnool, India, 518001
    • Government General Hospital
  • Lucknow, India, 226003
    • King George's Medical University
  • Lucknow, India, 226010
    • Dr. Ram Manohar Lohia Institute of Medical Sciences
  • Madurai, India, 625107
    • Meenakshi Mission Hospital & Research Centre
  • Mumbai, India, 400012
    • Seth G. S. Medical College and KEM Hospital
  • Mumbai, India, 400008
    • B. Y. L. Nair Charitable Hospital & Topiwala National Medical College
  • Nagpur, India, 440010
    • Arneja Heart Institute
  • Nagpur, India, 440015
    • Central India Cardiology Hospital and Research Institute
  • Nagpur, India, 440015
    • Swasthyam Superspeciality Hospital
  • Nagpur, India, 440012
    • Crescent Hospital & Heart Centre
  • Nagpur, India, 440025
    • NKP Salve Institute of Medical Sciences
  • Nashik, India, 422005
    • Chopda Medicare & Research Centre
  • Nashik, India, 422005
    • Vijan Cardiac and Critical Care
  • New Delhi, India, 110029
    • All India Institute of Medical Sciences
  • New Delhi, India, 110060
    • Sir Ganga Ram Hospital
  • New Delhi, India, 110017
    • Max Super Speciality Hospital
  • New Delhi, India, 110025
    • Fortis Escorts Heart Institute and Research Centre
  • New Delhi, India, 110025
    • Medanta The Medicity
  • New Delhi, India, 110 002
    • G B Pant Hospital
  • New Delhi, India, 110065
    • National Heart Institute
  • Ongole, India, 523001
    • Government Medical College and Hospital Ongole
  • Patna, India, 800014
    • Indira Gandhi Institute of Medical Sciences
  • Prayagraj, India, 211002
    • Moti Lal Nehru Medical College
  • Pune, India, 411001
    • Ruby Hall Clinic
  • Pune, India, 411028
    • Villoo Poonawalla Memorial Hospital
  • Pune, India, 411006
    • Sahyadri Super Speciality Hospital
  • Pune, India, 411040
    • Crescent India Medical Education Trust's Inamdar Hopital
  • Pune, India, 411011
    • KEM Hospital Research Center
  • Pune, India, 411043
    • Bharati Vidyapeeth Medical College
  • Raipur, India, 492001
    • SMC Heart Institute and IVF Research Centre
  • Rajkot, India, 360007
    • Sterling Hospital
  • Secunderabad, India, 500003
    • Krishna Institute of Medical Sciences
  • Shimla, India, 171006
    • Atal Institute of Medical Super Specialities Shimla
  • Surat, India, 395002
    • Nirmal Hospital Private Limited
  • Surat, India, 395002
    • Unicare Heart Institute
  • Ulhasnagar, India, 421004
    • Aashirwad Hospital
  • Vadodara, India, 390022
    • Rhythm Heart Institute
  • Vadodara, India, 390012
    • Jupiter Hospital
  • Vijayawada, India, 520008
    • Government Siddhartha Medical College
  • Visakhapatnam, India, 530002
    • King George Hospital
• Israel
  • Beersheba, Israel, 84100
    • Soroka University Medical Center
  • Hadera, Israel, 3810101
    • Hillel Yaffee Medical Center, Cardiology Department
  • Haifa, Israel, 3109601
    • Rambam Health Care Campus
  • Haifa, Israel, 3339419
    • Bnai Zion Medical Center, Cardiology
  • Holon, Israel, 5822012
    • Edith Wolfson Medical Center
  • Jerusalem, Israel, 9103102
    • Shaare Zedek Medical Center, Cardiology Department
  • Jerusalem, Israel, 9765422
    • Hadassah Hospital on Mount Scopus
  • Kfar Saba, Israel, 4428164
    • Meir Medical Center
  • Nahariya, Israel, 2210001
    • Galilee Medical Center
  • Petah Tikva, Israel, 49100
    • Rabin Medical Center
  • Rehovot, Israel, 76100
    • Kaplan Medical Center, Intensive Cardiac Care Unit
  • Safed, Israel, 13100
    • Ziv Medical Center
  • Tel Aviv, Israel, 6423906
    • Tel-Aviv Sourasky Medical Center
  • Tel Litwinsky, Israel, 5265601
    • Leviev Heart Center, Sheba Medical Center
  • Tiberias, Israel, 1528001
    • Health Corporation of Tzafon Medical Center
  • Ẕerifin, Israel, 6093000
    • Shamir Medical Center (Assaf Harofeh)
• Italy
  • Arezzo, Italy, 52100
    • San Donato Hospital, U.O.C. Cardiology
  • Bologna, Italy, 40133
    • Ospedale Maggiore Bologna - Dept. Cardiology
  • Caserta, Italy, 81100
    • AORN "Sant'Anna e San Sebastiano"
  • Catania, Italy, 95100
    • Azienda Ospedaliero-Universitaria Policlinico ""G. Rodolico - San Marco
  • Catania, Italy, 95123
    • Azienda Ospedaliero-Universitaria Policlinico "G. Rodolico - San Marco"
  • Catanzaro, Italy, 88100
    • AOU Mater Domini
  • Cona, Italy, 44124
    • University Hospital of Ferrara, Cardiology Unit
  • Florence, Italy, 50134
    • "SOD Cardiologia Interventistica Strutturale, AOU Careggi
  • Messina, Italy, 98124
    • A.O.U. Policlinico Gaetano Martino
  • Orbassano, Italy, 10043
    • AOU San Luigi Gonzaga Hospital
  • Perugia, Italy, 06129
    • Azienda Ospedaliera di Perugia
  • Perugia, Italy, 6129
    • Azienda Ospedaliera di Perugia
  • Torino, Italy, 10126
    • A.O.U.Città della Salute e della Scienza di Torino
  • Trento, Italy, 338122
    • Cardiology Department - Santa Chiara Hospital
  • Trento, Italy, 38122
    • Cardiology Department - Santa Chiara Hospital
  • Turin, Italy, 10098
    • Infermi Hospital in Rivoli (Turin)
• Japan
  • Akishima-shi, Japan, 196-0003
    • Tokushukai Tokyo-Nishi Tokushukai Hospital
  • Amagasaki-shi, Japan, 660-8550
    • Hyogo Prefectural Amagasaki General Medical Center
  • Asahi-shi, Japan, 289-2511
    • Asahi General Hospital
  • Bunkyō City, Japan, 113-8603
    • Nippon Medical School Hospital
  • Bunkyō City, Japan, 113-8510
    • Institute of Science Tokyo Hospital
  • Chiba, Japan, 260-8677
    • Chiba University Hospital
  • Chikushino-shi, Japan, 818-8516
    • Fukuokaken Saiseikai Futsukaichi Hospital
  • Chūō, Japan, 104-8560
    • St. Luke's International Hospital
  • Daito-shi, Japan, 574-0074
    • Tokushukai Nozaki Tokushukai Hospital
  • Fujieda, Japan, 426-8677
    • Fujieda Municipal General Hospital
  • Fukuoka, Japan, 811-0213
    • Chiyukai Fukuoka Wajiro Hospital
  • Hachioji-shi, Japan, 192-0918
    • Kenshinkai Minamino Cardiovascular Hospital
  • Hakodate-shi, Japan, 041-8680
    • Hakodate Municipal Hospital
  • Hamamatsu, Japan, 430-8558
    • Seirei Hamamatsu General Hospital
  • Himeji-shi, Japan, 670-8560
    • Hyogo Prefectural Harima-Himeji General Medical Center
  • Hiratsuka-shi, Japan, 254-8502
    • Hiratsuka Kyosai Hospital
  • Hirosaki, Japan, 036-8563
    • Hirosaki University Hospital
  • Izunokuni-shi, Japan, 410-2295
    • Juntendo University Shizuoka Hospital
  • Kamakura-shi, Japan, 247-8533
    • Tokushukai Shonan Kamakura General Hospital
  • Kasama-shi, Japan, 310-0021
    • Ibaraki Prefectural Central Hospital
  • Kasugai-shi, Japan, 486-8510
    • Kasugai Municipal Hospital
  • Kawaguchi, Japan, 332-8558
    • Saiseikai Kawaguchi General Hospital
  • Kawasaki-shi, Japan, 215-0026
    • Shin-yurigaoka General Hospital
  • Kisarazu-shi, Japan, 292-8535
    • Kimitsu Chuo Hospital
  • Kita-gun, Japan, 761-0793
    • Kagawa University Hospital
  • Kobe, Japan, 654-0026
    • Sakurakai Takahashi Hospital
  • Koga-shi, Japan, 811-3195
    • NHO Fukuoka Higashi Medical Center
  • Kukichūō, Japan, 346-8530
    • Shin-Kuki General Hospital
  • Kumamoto, Japan, 861-4193
    • Saiseikai Kumamoto Hospital
  • Kumamoto, Japan, 861-8520
    • Japanese Red Cross Kumamoto Hospital
  • Kusatsu-shi, Japan, 525-8585
    • Omi Medical Center
  • Kuwana, Japan, 511-0061
    • Kuwana City Medical Center
  • Kyoto, Japan, 602-8566
    • University Hospital, Kyoto Prefectural University of Medicine
  • Kōtoku, Japan, 135-8577
    • Showa Medical University Koto Toyosu Hospital
  • Matsumoto, Japan, 390-8621
    • Shinshu University Hospital
  • Meguro-ku, Japan, 153-8515
    • Toho University Ohashi Medical Center
  • Meguro-ku, Japan, 152-8902
    • NHO Tokyo Medical Center
  • Minatoku, Japan, 105-8470
    • Toranomon Hospital
  • Musashino-shi, Japan, 180-8610
    • Japanese Red Cross Musashino Hospital
  • Nagasaki, Japan, 850-8555
    • Nagasaki Harbor Medical Center
  • Nagoya, Japan, 466-8650
    • Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital
  • Okayama, Japan, 700-8558
    • Okayama University Hospital
  • Okayama, Japan, 701-1192
    • NHO Okayama Medical Center
  • Ome-shi, Japan, 198-0042
    • Ome Medical Center
  • Omura-shi, Japan, 856-8562
    • NHO Nagasaki Medical Center
  • Osaka, Japan, 540-0006
    • NHO Osaka National Hospital
  • Osaka, Japan, 558-8558
    • Osaka General Medical Center (Kyuseiki Sogo Iryo C)
  • Saga, Japan, 840-8571
    • Saga-ken Medical Centre Koseikan
  • Sagamihara-shi, Japan, 252-0375
    • Kitasato University Hospital
  • Saitama-shi, Japan, 339-0033
    • Kosekai Iwatsuki-minami Hospital
  • Sakyo-ku, Japan, 606-8507
    • Kyoto University Hospital
  • Sapporo, Japan, 065-0033
    • Tokushukai Sapporo Higashi Tokushukai Hospital
  • Shibuya-ku, Japan, 150-0013
    • Tokyo Metropolitan Hiroo Hospital
  • Shiroyamachō, Japan, 892-0853
    • NHO Kagoshima Medical Center
  • Shōwaku, Japan, 466-8560
    • Nagoya University Hospital
  • Tanabe-shi, Japan, 646-8558
    • NHO Minami Wakayama Medical Center
  • Tsu, Japan, 514-8507
    • Mie University Hospital
  • Ube-shi, Japan, 755-8505
    • Yamaguchi University Hospital
  • Urayasu-shi, Japan, 279-0001
    • Tokyobay Urayasu Ichikawa Medical Center
  • Yokohama, Japan, 221-0855
    • Yokohama Municipal Citizen's Hospital
  • Yokohama, Japan, 236-0051
    • Kanagawa Cardiovascular and Respiratory Center
  • Yokohama, Japan, 247-8581
    • Yokohama Sakae Kyosai Hospital
  • tabashi City, Japan, 173-8606
    • Teikyo University Hospital
  • tabashi City, Japan, 173-8610
    • Nihon University Itabashi Hospital
  • Ōita, Japan, 870-0263
    • NHO Oita Medical Center
• Latvia
  • Liepāja, Latvia, LV- 3401
    • D.Saulites-Kandevicas Private Practice
  • Riga, Latvia, LV 1002
    • Pauls Stradins Clinical University Hospital
• Lithuania
  • Kaunas, Lithuania, 50161
    • Hospital of Lithuanian University of Health Sciences Kauno Klinikos
  • Klaipėda, Lithuania, 92288
    • Klaipeda Seamen's Hospital
  • Panevezys, Lithuania, 35144
    • Republican Panevezys Hospital
  • Vilnius, Lithuania, 08661
    • Vilnius University Hospital Santaros Klinikos
• Malaysia
  • Alor Star, Malaysia, 5460
    • Hospital Sultanah Bahiyah
  • Ipoh, Malaysia, 30450
    • Hospital Raja Permaisuri Bainun
  • Kota Bharu, Malaysia, 15586
    • Hospital Raja Perempuan Zainab Ii
  • Kota Kinabalu, Malaysia, 88300
    • Hospital Queen Elizabeth II
  • Kuala Lumpur, Malaysia, 59100
    • Universiti Malaya Medical Centre
  • Kuala Lumpur, Malaysia, 50450
    • Prince Court Medical Centre
  • Kuantan, Malaysia, 25100
    • Hospital Tengku Ampuan Afzan
  • Miri, Malaysia, 98000
    • Hospital Miri
  • Perai, Malaysia, 13700
    • Sunway Medical Centre Penang
  • Sungai Buloh, Malaysia, 47000
    • Hospital UiTM Sungai Buloh
• Netherlands
  • 's-Hertogenbosch, Netherlands, 5223 GZ
    • Jeroen Bosch Ziekenhuis
  • Alkmaar, Netherlands, 1815 JD
    • Noordwest Ziekenhuisgroep
  • Amersfoort, Netherlands, 3813TZ
    • Meander Medisch Centrum
  • Amsterdam, Netherlands, 1105 AZ
    • Amsterdam UMC
  • Amsterdam, Netherlands, 1091 AC
    • Onze Lieve Vrouwe Gasthuis, locatie Oost
  • Apeldoorn, Netherlands, 7334 DZ
    • Gelre Ziekenhuis Apeldoorn
  • Arnhem, Netherlands, 6815 AD
    • Rijnstate Ziekenhuis
  • Breda, Netherlands, 4818 CK
    • Amphia Ziekenhuis
  • Deventer, Netherlands, 7416SE
    • Deventer Ziekenhuis
  • Dordrecht, Netherlands, 3318AT
    • Albert Schweitzer Ziekenhuis
  • Ede, Netherlands, 6716 RP
    • Gelderse Vallei Ziekenhuis
  • Eindhoven, Netherlands, 5623 EJ
    • Catharina Hospital
  • Goes, Netherlands, 4462RA
    • Admiraal de Ruyter Ziekenhuis
  • Groningen, Netherlands, 9700 RB
    • UMC Groningen
  • Heerlen, Netherlands, 6419 PC
    • Zuyderland Medical Center
  • Hilversum, Netherlands, 1212VG
    • Tergooi Mc
  • Hoorn, Netherlands, 1624 NP
    • Vasculair Onderzoek Centrum Hoorn
  • Leeuwarden, Netherlands, 8934 AD
    • Frisius Medisch Centrum
  • Nijmegen, Netherlands, 6525GA
    • Radboud UMC
  • Nijmegen, Netherlands, 6532SZ
    • Canisius-Wilhelmina Ziekenhuis
  • Roosendaal, Netherlands, 4708AE
    • Bravis Ziekenhuis
  • Tiel, Netherlands, 4002WP
    • Ziekenhuis Rivierenland
  • Tilburg, Netherlands, 5042AD
    • Elisabeth-TweeSteden Ziekenhuis
  • Utrecht, Netherlands, 3582KE
    • Diakonessenhuis Utrecht
  • Veldhoven, Netherlands, 5504DB
    • Maxima Medisch Centrum
• New Zealand
  • Hamilton, New Zealand, 3240
    • Waikato Hospital
  • New Plymouth, New Zealand, 4342
    • Taranaki Base Hospital
  • Rotorua, New Zealand, 3010
    • Health New Zealand Te Whatu Ora Lakes
  • Tauranga, New Zealand, 3112
    • Bay of Plenty Clinical School Charitable Trust
• Norway
  • Arendal, Norway, 4809
    • Sørlandet Hospital Arendal
  • Bodø, Norway, 8005
    • Nordland Hospital Trust
  • Lørenskog, Norway, 1478
    • Akershus University Hospital
  • Oslo, Norway, 0372
    • Oslo University Hospital Rikshospitalet
  • Oslo, Norway, 0370
    • Diakonhjemmet Hospital
  • Oslo, Norway, 0450
    • Oslo University Hospital, Ullevål hospital
  • Sarpsborg, Norway, 1714
    • Sykehuset Østfold Kalnes (Trust)
  • Stavanger, Norway, 4011
    • Stavanger University Hospital
  • Tønsberg, Norway, 3103
    • Vestfold Hospital
  • Ålesund, Norway, 6017
    • Ålesund Hospital
• Philippines
  • Dasmariñas, Philippines, 4114
    • CARE CT Group Inc.
  • Iloilo City Proper, Philippines, 5000
    • St. Paul's Hospital of Iloilo, Inc
  • Lipa, Philippines, 4217
    • Mary Mediatrix Medical Center
  • Mandaluyong, Philippines, 1552
    • Dr. William Chua Center for Clinical Research, Health Cube Medical Clinics
  • San Fernando City, Philippines, 2500
    • Lorma Medical Center
• Poland
  • Bialystok, Poland, 15-276
    • Invasive Cardiology Department, University Teaching Hospital in Białystok
  • Bielsk Podlaski, Poland, 17-100
    • Centrum Kardiologii Scanmed w Bielsku Podlaskim
  • Bielsko-Biala, Poland, 43-316
    • Polsko-Amerykanskie Kliniki Serca
  • Bydgoszcz, Poland, 85-095
    • Specjalistyczna Praktyka Lekarska Paweł Grzelakowski Centrum Kardiologii Paewł Grzelakowski
  • Bydgoszcz, Poland, 85-092
    • Centrum Medyczne Hipokrates S C Elzbieta I Grzegorz Grzesk
  • Gdansk, Poland, 80-214
    • Uniwersyteckie Centrum Kliniczne
  • Katowice, Poland, 40-635
    • Górnośląskie Centrum Medyczne w Katowicach, III Oddział Kardiologii
  • Katowice, Poland, 40-156
    • Clinical Medical Research Sp. z o.o.
  • Katowice, Poland, 40-600
    • Gyncentrum sp. z o.o.
  • Krakow, Poland, 30-688
    • Szpital Uniwersytecki w Krakowie, Oddział Kliniczny Kardiologii oraz Interwencji Sercowo-Naczyniowych
  • Krakow, Poland, 30-721
    • Linden Sp. z o.o. sp.k.
  • Krosno, Poland, 38-400
    • Centrum Kardiologii Inwazyjnej Elektroterapii i Angiologii w Krośnie
  • Legnica, Poland, 59-220
    • Wojewodzki Szpital Specjalistyczny
  • Lodz, Poland, 91-002
    • Nzoz Salusmed Jan Zbigniew Peruga Pphu Salus Poradnia Kardiologiczna
  • Lodz, Poland, 91-034
    • Centrum Medyczne Med-GASTR SP. Z O.O
  • Lublin, Poland, 59-301
    • Miedziowe Centrum Zdrowia Regionalny, Ośrodek Kardiologiczny, Pracownia Angiografii i Hemodynamiki
  • Lublin, Poland, 20-601
    • Zanamed Medical Clinic sp z o o
  • LÓDZ, Poland, 93-487
    • Wojewodzki Szpital Specj im.W Bieganskiego
  • Olsztyn, Poland, 10-561
    • Wojewódzki Szpital Specjalistyczny w Olsztynie, Oddział Kardiologii
  • Poznan, Poland, 61-853
    • NZOZ Neuro-Kard Ilkowski i Partnerzy Spółka Partnerska Lekarzy
  • Poznan, Poland, 60-254
    • INKARD Sp. Z O.O. Sp. JAWNA
  • Poznan, Poland, 61-848
    • Szpital Kliniczny im. Heliodora Swiecickiego Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu
  • Przemyśl, Poland, 37-700
    • Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu
  • Torun, Poland, 87-100
    • Oddzial Kardiologii i intensywnej Terapii Kardiologicznej
  • Warsaw, Poland, 02-097
    • Pracownia Kardiologii Inwazyjnej I Katedry i Kliniki Kardiologii Uniwersyteckiego Centrum Klinicznego Warszawskiego Uniwersytetu Medycznego
  • Warsaw, Poland, 04-628
    • Narodowy Instytut Kardiologii
  • Warsaw, Poland, 02-677
    • ETG Warszawa Sp z o.o.
  • Weigla, Poland, 53-114
    • 4 Wojskowy Szpital Kliniczny z Poliklinika SP ZOZ
  • Wroclaw, Poland, 54-049
    • Dolnoslaski Szpital Specjalistyczny im. T.Marciniaka - Centrum Medycyny Ratunkowej
  • Wroclaw, Poland, 50-556
    • Uniwersytecki Szpital Kliniczny we Wroclawiu
  • Zabrze, Poland, 41-800
    • SCCS Zabrze I i II Oddział Kardiologii i Angiologii
• Portugal
  • Aveiro, Portugal, 3814-501
    • Unidade Local de Saúde da Região de Aveiro, E.P.E.
  • Coimbra, Portugal, 3000 075
    • Unidade Local de Saude de Coimbra EPE
  • Leiria, Portugal, 2410-197
    • Unidade Local de Saúde da Região de Leiria, E.P.E.
  • Lisbon, Portugal, 1649-035
    • Unidade Local de Saúde de Santa Maria, E.P.E.
• Romania
  • Baia Mare, Romania, 430031
    • Spitalul Judetean de Urgenta "Dr. Constantin Opris" Baia Mare
  • Brasov, Romania, 500091
    • Centrul Medical Unirea S.R.L
  • Bucharest, Romania, 41915
    • Spitalul Clinic de Urgenta "Bagdasar-Arseni"
  • Bucharest, Romania, 14461
    • Spitalul Clinic de Urgenta Bucuresti
  • Bucharest, Romania, 14142
    • Delta Health Care SRL
  • Bucharest, Romania, 10242
    • Spitalul Universitar de Urgenta Militar Central "Dr. Carol Davila"
  • Cluj-Napoca, Romania, 400006
    • Spitalul Clinic Judetean de Urgenta Cluj Napoca
  • Cluj-Napoca, Romania, 400001
    • Institutul Inimii de Urgență pentru Boli Cardiovasculare "Niculae Stăncioiu"
  • Craiova, Romania, 200642
    • Spitalul Clinic Judetean De Urgenta Craiova
  • Oradea, Romania, 410169
    • Spitalul Clinic Judetean de Urgenta Bihor
  • Satu Mare, Romania, 440192
    • Spitalul Județean de Urgență Satu Mare
  • Timișoara, Romania, 300310
    • Institute of Cardiovascular Diseases Timisoara
  • Timișoara, Romania, 300079
    • Spitalul Clinic Municipal de Urgenta Timisoara
  • Timișoara, Romania, 300362
    • S.C Medicali's S.R.L
  • Târgu Mureş, Romania, 540136
    • County Clinical Emergency Hospital Targu Mures
  • Târgu Mureş, Romania, 540143
    • Podoleanu G. Cristian-Gheorghe-Calin - Cabinet Medical De Cardiologie
  • Târgu Mureş, Romania, 540136
    • Institutul de Urgenta pentru Boli Cardiovasculare si Transplant Targu Mures
• Serbia
  • Belgrade, Serbia, 11000
    • Kliničko bolnički centar "Zvezdara"
  • Belgrade, Serbia, 11080
    • Department of Cardiology, Clinical Hospital Center Zemun
  • Belgrade, Serbia, 11080
    • Klinicko bolnicki centar, Bežanijska kosa
  • Belgrade, Serbia, 11080
    • Kliničko Bolnički Centar Bežanijska Kosa
  • Belgrade, Serbia, 11080
    • Clin Hosp Ctr Zemun - Cardiology Dept
  • Belgrade, Serbia, 11000
    • University Clinical Center of Serbia (Department for Cardiovascular Disease Cardiology Clinic)
  • Belgrade, Serbia, 11000
    • University Clinical Center of Serbia (Diagnostic and Catheterization Lab)
  • Belgrade, Serbia, 11000
    • University Clinical Center of Serbia (Emergency Cardiology Services)
  • Belgrade, Serbia, 11040
    • University Hospital Centre Dr Dragiša Mišovic - Dedinje
  • Kamenitz, Serbia, 21204
    • Institute of Cardiovascular Diseases, Vojvodina
  • Kragujevac, Serbia, 34000
    • Klinički centar Kragujevac
  • Leskovac, Serbia, 16000
    • Opšta bolnica Leskovac
  • Niš, Serbia, 18000
    • Klinički Centar Niš
  • Novi Pazar, Serbia, 36300
    • Opsta bolnica Novi Pazar
  • Subotica, Serbia, 24000
    • Opsta bolnica Subotica
  • Užice, Serbia, 31000
    • Opšta bolnica Užice
  • Zaječar, Serbia, 19000
    • Zdravstveni Centar Zajecar
• Slovakia
  • Banská Bystrica, Slovakia, 97401
    • Central Slovak Institute of Cardiovascular Diseases
  • Bratislava, Slovakia, 811 02
    • Premedix Clinic
  • Bratislava, Slovakia, 813 69
    • University Hospital Bratislava
  • Bratislava, Slovakia, 851 05
    • Cardiocentre CINRE
  • Košice, Slovakia, 04011
    • Východoslovenský ústav srdcových a cievnych chorôb
  • Nitra, Slovakia, 94901
    • Kardiocentrum Nitra
• South Africa
  • Bloemfontein, South Africa, 9301
    • Iatros International
  • Bloemfontein, South Africa, 9301
    • Josha Research
  • Cape Town, South Africa, 7500
    • TREAD Research
  • East London, South Africa, 5241
    • Synergy Biomed Research Institute (SBRI)
  • Johannesburg, South Africa, 2192
    • Futurex Clinical
  • Mossel Bay, South Africa, 6500
    • Eden Heart
  • Paarl, South Africa, 7646
    • Paarl Research Centre
  • Somerset West, South Africa, 7130
    • Dr JM Engelbrecht Trial Site
• South Korea
  • Bucheon-si, South Korea, 14647
    • The Catholic University of Korea, Bucheon, St. Mary's Hospital
  • Busan, South Korea, 49201
    • Dong-A University Hospital
  • Cheongju-si, South Korea, 28644
    • Chungbuk National University Hospital
  • Daegu, South Korea, 42601
    • Keimyung University Dongsan Hospital
  • Daegu, South Korea, 42472
    • Daegu Catholic University Medical Center
  • Daejeon, South Korea, 35015
    • Chungnam National University Hospital
  • Gangseo-gu, South Korea, 7804
    • Ewha Womans University Seoul Hospital
  • Goyang-si, South Korea, 10475
    • Myongji Hospital
  • Incheon, South Korea, 21565
    • Gachon University Gil Medical Center
  • Seoul, South Korea, 6273
    • Gangnam Severance Hospital, Yonsei University Health System
  • Seoul, South Korea, 5505
    • Asan Medical Center
  • Seoul, South Korea, 5278
    • Kyung Hee University Hospital at Gangdong
  • Seoul, South Korea, 2841
    • Korea University Anam Hospital
  • Seoul, South Korea, 8308
    • Korea University Guro Hospital
  • Seoul, South Korea, 2447
    • Kyung Hee University Hospital
• Spain
  • Badalona, Spain, 08916
    • Hospital Universitari Germans Trias i Pujol
  • Barcelona, Spain, 08025
    • Hospital De La Santa Creu I Sant Pau
  • Barcelona, Spain, 08036
    • Hospital Clinic. Barcelona
  • Córdoba, Spain, 14004
    • Hospital Universitario Reina Sofia
  • El Palmar, Spain, 30120
    • Hospital Universitario Virgen de la Arrixaca
  • Fuencarral-El Pardo, Spain, 28046
    • Hospital Universitario La Paz
  • Huelva, Spain, 21005
    • Hospital Universitario Juan Ramón Jiménez
  • L'Hospitalet de Llobregat, Spain, 08907
    • Hospital Universitari de Bellvitge
  • Madrid, Spain, 28034
    • Hospital Universitario Ramon y Cajal
  • Madrid, Spain, 28040
    • Hospital Clinico San Carlos
  • Madrid, Spain, 28041
    • Hospital Universitario 12 de Octubre
  • Madrid, Spain, 28006
    • Hospital Universitario de la Princesa
  • Málaga, Spain, 29004
    • Hospital Quironsalud Malaga
  • Pamplona, Spain, 31008
    • Complejo Hospitalario de Navarra
  • Santiago de Compostela, Spain, 15706
    • Hospital Clinico Universitario de Santiago
  • Seville, Spain, 41013
    • Hospital Universitario Virgen del Rocio
  • Valencia, Spain, 46010
    • Hospital Clinico Valencia
  • Vigo, Spain, 36312
    • Hospital Alvaro Cunqueiro, Cardiovascular Unit
• Sweden
  • Falun, Sweden, 79182
    • Falu Lasarett
  • Gothenburg, Sweden, 41345
    • Sahlgrenska Universitetssjukhuset
  • Jönköping, Sweden, 551 85
    • Länssjukhuset Ryhov
  • Linköping, Sweden, 58185
    • Linköpings University Hospital
  • Malmö, Sweden, 20502
    • Skåne Universitetssjukhus
  • Norrköping, Sweden, 60379
    • Vrinnevisjukhuset
  • Västerås, Sweden, 72189
    • Västmanlands sjukhus
  • Örebro, Sweden, 70185
    • Universitetssjukhuset Örebro
• Switzerland
  • Basel, Switzerland, 4031
    • Universitätsspital Basel; Universitäres Herzzentrum
  • Bern, Switzerland, 3010
    • Inselspital, Universitäatspital Bern, Universitäatklinik für Kardiologie
  • Lugano, Switzerland, 6900
    • Istituto Cardiocentro Ticino
  • Sankt Gallen, Switzerland, 9007
    • HOCH Health Ostschweiz, Kantonsspital St. Gallen
• Taiwan
  • Changhua, Taiwan, 500209
    • Changhua Christian Hospital
  • Hualien City, Taiwan, 970
    • Hualien Tzu Chi Hospital
  • Kaohsiung City, Taiwan, 807
    • Kaohsiung Medical University Chung-Ho Memorial Hospital
  • Kaohsiung City, Taiwan, 813414
    • Kaohsiung Veterans General Hospital
  • Kaohsiung City, Taiwan, 833401
    • Chang Gung Medical Foundation-Kaohsiung
  • New Taipei City, Taiwan, 251404
    • Mackay Memorial Hospital Tamsui
  • Taichung, Taiwan, 40201
    • Chung Shan Medical University Hospital, Taichung
  • Tainan, Taiwan, 71004
    • Chi Mei Medical Center
  • Taipei, Taiwan, 11217
    • Taipei Veterans General Hospital
  • Taipei, Taiwan, 100225
    • National Taiwan University Hospital
  • Taipei, Taiwan, 114202
    • Tri-Service General Hospital
  • Taitung, Taiwan, 950408
    • Taitung MacKay Memorial Hospital
  • Taoyuan City, Taiwan, 333423
    • Linkou Chang Gung Memorial Hospital
• Thailand
  • Bangkok, Thailand, 10700
    • Siriraj Hospital
  • Bangkok, Thailand, 10220
    • Bhumibol Adulyadej Hospital
  • Chiang Mai, Thailand, 50200
    • Faculty of Medicine, Chiang Mai University
  • Chiang Rai, Thailand, 57000
    • Chiangrai Prachanukroh Hospital
  • Khon Kaen, Thailand, 40002
    • Srinagarind Hospital, Khon Kaen University
  • Pathum Thani, Thailand, 12120
    • Thammasat University Hospital
  • Phitsanulok, Thailand, 65000
    • Buddhachinaraj Phitsanulok Hospital
  • Samut Sakhon, Thailand, 74120
    • Banphaeo General Hospital
  • Songkhla, Thailand, 90110
    • Songklanagarind Hospital
  • Ubon Ratchathani, Thailand, 34190
    • Fort Sanpasitthiprasong Hospital
• United Kingdom
  • Bradford, United Kingdom, BD9 6RJ
    • Bradford Teaching Hospitals NHS Foundation Trust
  • Cambridge, United Kingdom, CB2 0AY
    • Royal Papworth Hospital NHS Foundation Trust
  • London, United Kingdom, EC1A 7BE
    • Barts Health NHS Trust
  • Londonderry, United Kingdom, BT47 65B
    • Altnagelvin Area Hospital (WHSCT)
  • North Shields, United Kingdom, NE29 8NH
    • North Tyneside General Hospital, Northumbria Healthcare
  • Portadown, United Kingdom, BT63 5QQ
    • Southern Health & Social Care Trust
  • Sheffield, United Kingdom, S5 7AU
    • Northern General Hospital
  • Stevenage, United Kingdom, SG1 4AB
    • Lister Hospital East and North Hertfordshire NHS Trust
  • Worcester, United Kingdom, WR5 1DD
    • Worcestershire Acute Hospital NHS Trust
• United States
  • Alabama
    • Alexander City, Alabama, United States, 35010
      • Advanced Cardiovascular, LLC
    • Birmingham, Alabama, United States, 35243
      • Cardiovascular Associates of the Southeast
    • Birmingham, Alabama, United States, 35233
      • Birmingham VA Health Care System
    • Birmingham, Alabama, United States, 35243
      • Grandview Medical Center and Affinity Cardiovascular Specialists, LCC
    • Huntsville, Alabama, United States, 35801
      • Heart Center Research, LLC
  • Arizona
    • Gilbert, Arizona, United States, 85297
      • Dignity Health Mercy Gilbert Medical Center
    • Phoenix, Arizona, United States, 85054
      • Mayo Clinic Arizona
    • Tucson, Arizona, United States, 85724
      • University of Arizona - Sarver Heart Center
  • California
    • Anaheim, California, United States, 92801
      • Amicis Research Center.
    • Concord, California, United States, 94520
      • John Muir Health
    • La Jolla, California, United States, 92037
      • Profound Research LLC at San Diego Cardiovascular Associates
    • San Francisco, California, United States, 94121
      • San Francisco VA Health Care System"
    • Santa Maria, California, United States, 93454
      • Fomat Medical Research
    • Torrance, California, United States, 90502
      • Lundquist Institute for Biomedical Innovation at Harbor - UCLA Medical Center
    • Van Nuys, California, United States, 91405
      • InvivoCure
    • West Hills, California, United States, 91307
      • Interventional Cardiology Medical Group
  • Colorado
    • Golden, Colorado, United States, 80401
      • Colorado Heart and Vascular PC
    • Littleton, Colorado, United States, 80120
      • South Denver Cardiology Associates, PC
  • Delaware
    • Newark, Delaware, United States, 19718
      • Christiana Care Health Services, Inc.
  • District of Columbia
    • Washington D.C., District of Columbia, United States, 20010
      • Medstar Washington Hospital Center
  • Florida
    • Boca Raton, Florida, United States, 33486
      • FWD Clinical Research
    • Brandon, Florida, United States, 33511
      • Bay Area Cardiology Associates, P.A.
    • Clearwater, Florida, United States, 33756
      • Clearwater Cardiovascular Consultants
    • Coral Gables, Florida, United States, 33134
      • Pioneer Clinical Studies (PCS)
    • Jacksonville, Florida, United States, 32209
      • University of Florida Health Science Center at Jacksonville
    • Pensacola, Florida, United States, 32504
      • Ascension Sacred Heart
    • Pensacola, Florida, United States, 32503
      • Baptist Health Care, Inc. d/b/a Baptist Hospital Cardiology
    • Safety Harbor, Florida, United States, 34695
      • Clearwater Cardiovascular Consultants
    • Saint Augustine, Florida, United States, 32086
      • St. Johns Center for Clinical Research
  • Georgia
    • Columbus, Georgia, United States, 31904
      • Centricity Research Columbus Georgia Multispecialty
    • Decatur, Georgia, United States, 30033
      • Atlanta VA Medical Center
  • Illinois
    • Glenview, Illinois, United States, 60026
      • Endeavor Health
    • Peoria, Illinois, United States, 61614
      • OSF HealthCare Cardiovascular Institute
  • Indiana
    • Indianapolis, Indiana, United States, 46202
      • Indiana University School of Medicine
    • Muncie, Indiana, United States, 47304
      • Indiana University Health Ball Memorial Hospital
    • Richmond, Indiana, United States, 47374
      • Reid Physician Associates
  • Kentucky
    • Edgewood, Kentucky, United States, 41017
      • St. Elizabeth Healthcare
    • Louisville, Kentucky, United States, 40202
      • University of Louisville
  • Louisiana
    • Bossier City, Louisiana, United States, 71111
      • Grace Research, LLC
    • Hammond, Louisiana, United States, 70403
      • Heart Clinic of Hammond
  • Maine
    • Bangor, Maine, United States, 04401
      • Northern Light Eastern Maine Medical Center
  • Maryland
    • Baltimore, Maryland, United States, 21215
      • Sinai Hospital Baltimore, LifeBridge Health
    • Silver Spring, Maryland, United States, 20904
      • Adventist Healthcare White Oak Medical Center
  • Michigan
    • Farmington Hills, Michigan, United States, 48334
      • Profound Research LLC at Millenium Cardiology
    • Midland, Michigan, United States, 48670
      • MyMichigan Medical Center - Midland
  • Minnesota
    • Saint Paul, Minnesota, United States, 55101
      • Regions Hospital
  • Mississippi
    • Tupelo, Mississippi, United States, 38801
      • Cardiology Associates Research
  • Missouri
    • Columbia, Missouri, United States, 65212
      • University of Missouri Healthcare
  • New Jersey
    • Bridgewater, New Jersey, United States, 08807
      • Advanced Heart Care, LLC
    • Jersey City, New Jersey, United States, 07306
      • Garden State Advanced Medical Group
    • Newark, New Jersey, United States, 07102
      • Saint Michael's Medical Center
    • Newark, New Jersey, United States, 07103
      • Rutgers New Jersey Medical School
    • Pomona, New Jersey, United States, 08240
      • AtlantiCare Regional Medical Center
  • New York
    • Cooperstown, New York, United States, 13326
      • Bassett Medical Center
    • Liverpool, New York, United States, 13088
      • St. Joseph's Hospital Cardiology
    • New York, New York, United States, 10010
      • VA NY Harbor Healthcare System
    • Rochester, New York, United States, 14642
      • University of Rochester - PARENT
  • North Carolina
    • Charlotte, North Carolina, United States, 28173
      • Mecklenburg Heart Specialists
    • Durham, North Carolina, United States, 27710
      • Duke University Medical Center
    • Greensboro, North Carolina, United States, 27401
      • Moses H. Cone Memorial Hospital Operation Corporation d/b/a Cone Health
  • Ohio
    • Cleveland, Ohio, United States, 44106
      • University Hospitals Cleveland Medical Center
  • Oklahoma
    • Oklahoma City, Oklahoma, United States, 73104
      • University of Oklahoma Health Sciences Center
  • Pennsylvania
    • Chambersburg, Pennsylvania, United States, 17201
      • Wellspan Chambersburg Hospital
    • Hershey, Pennsylvania, United States, 17033
      • Penn State Health Milton S. Hershey Medical Center
    • Sayre, Pennsylvania, United States, 18840
      • Donald Guthrie Foundation
    • Wyomissing, Pennsylvania, United States, 19160
      • Penn State Health Medical Group - Berks Cardiology
  • South Carolina
    • Greenville, South Carolina, United States, 29605
      • Prisma Health - Upstate
  • South Dakota
    • Rapid City, South Dakota, United States, 57701
      • Monument Health Clinical Research, Monument Health Rapid City Hospital Inc.
  • Tennessee
    • Chattanooga, Tennessee, United States, 37404
      • CHI Institute for Research and Innovation
    • Memphis, Tennessee, United States, 38120
      • Baptist Clinical Research Institute
    • Nashville, Tennessee, United States, 27232
      • Vanderbilt University Medical Center
    • Oak Ridge, Tennessee, United States, 37830
      • Covenant Medical Group d/b/a Parkway Cardiology Associates
    • Powell, Tennessee, United States, 37849
      • Cardiovascular Research of Knoxville
  • Texas
    • Amarillo, Texas, United States, 79106
      • Amarillo Heart Clinical Research Institute Inc.
    • Amarillo, Texas, United States, 79106
      • PharmaTex Research
    • McKinney, Texas, United States, 75071
      • North Texas Research Associates
  • Virginia
    • Charlottesville, Virginia, United States, 22908
      • UVA University Hospital
    • Falls Church, Virginia, United States, 22042
      • Virginia Heart
    • Falls Church, Virginia, United States, 22042
      • Inova Heart & Vascular Institute
    • Richmond, Virginia, United States, 23226
      • Bon Secours St. Mary's Hospital of Richmond, LLC
  • Wisconsin
    • Milwaukee, Wisconsin, United States, 53215
      • Aurora St. Luke's Medical Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Main Inclusion Criteria:

• Confirmed diagnosis of symptomatic type 1 acute myocardial infarction (AMI) ST-Elevation Myocardial Infarction (STEMI) or Non-ST-Elevation Myocardial Infarction (NSTEMI), no longer than 4 weeks prior to randomization.

• Diagnosis of multivessel coronary artery disease defined as ≥ 50% stenosis on 2 or more coronary artery territories, during a prior cardiac catheterization or cardiac catheterization during the qualifying AMI event and presence of at least 1 of the following risk factors:

  • Second prior AMI,
  • Diabetes mellitus defined by ongoing glucose lowering treatment,
  • Chronic kidney disease defined as estimated glomerular filtration rate less than 60 mL/min/1.73 m2 and either known history of chronic kidney disease or a biomarker of chronic kidney damage,
  • Peripheral artery disease at any time prior to randomization,
  • Absence of, or unsuccessful coronary revascularization of the qualifying AMI.
• Successful self-administered placebo according to the autoinjector instruction for use training during screening.

Main Exclusion Criteria:

• Increased risk of serious bleeding including any of the following:

  • History of intracranial bleed at any time.
  • Known uncorrected intracranial vascular abnormality.
  • Gastrointestinal bleed requiring hospitalization or transfusion within 1 year prior to screening.
  • Already on oral triple antithrombotic therapy (i.e., Dual antiplatelet therapy and oral anticoagulant).
  • Known liver impairment significantly affecting the hepatic function.
  • Current dialysis.
  • Ischemic stroke or transient ischemic attack within 3 months of screening.
• Chronic anemia with hemoglobin < 10 g/dL.
• Chronic thrombocytopenia with platelet count < 100,000/mm3.
• Known hypersensitivity to selatogrel, any of its excipients, or drugs of the P2Y12 class.
• Previous exposure to an investigational drug within 3 months prior to randomization.
• Participation in another clinical trial with an investigational product or device within 3 months prior to randomization.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Triple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Selatogrel; Study treatment administration may occur at any time between the randomization visit and the final study visit when the participant experiences symptoms suggestive of an acute myocardial infarction. Study treatment administration triggers protocol pre-defined assessments or visits.	Combination product: Selatogrel; Selatogrel is a reversible P2Y12 receptor antagonist for subcutaneous administration. Selatogrel will be administered as a liquid formulation in a sealed prefilled syringe in an autoinjector forming an integral ready-to-use, single-dose drug delivery system. Participants will self-administer 16 mg of selatogrel subcutaneously with the autoinjector upon occurrence of symptoms suggestive of an acute myocardial infarction. Self-administration encompasses the use of the autoinjector by another person (e.g., partner, close relative, friend, caregiver) who may be called for help during the emergency situation of a suspected AMI.; Other Names: ACT-246475
Placebo Comparator: Placebo; Study treatment administration may occur at any time between the randomization visit and the final study visit when the participant experiences symptoms suggestive of an acute myocardial infarction. Study treatment administration triggers protocol pre-defined assessments or visits.	Combination product: Placebo; Placebo will be administered as a liquid formulation in a sealed prefilled syringe in an autoinjector forming an integral ready-to-use, single-dose drug delivery system. Participants will self-administer placebo subcutaneously with the autoinjector upon occurrence of symptoms suggestive of an acute myocardial infarction. Self-administration encompasses the use of the autoinjector by another person (e.g., partner, close relative, friend, caregiver) who may be called for help during the emergency situation of a suspected AMI.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Clinical status as assessed by a 6-point ordinal scale	The clinical status will be assessed using a 6-point ordinal scale after any study treatment self-administration. Only the worst clinical outcome will be retained as the primary efficacy outcome. The 6 mutually exclusive outcomes ranked from worst to best are: Death (all causes), within 7 days after study treatment administration.; Acute myocardial infarction with compromised electro-hemodynamics, within 2 days after study treatment administration.; ST-Elevation Myocardial Infarction (STEMI), within 2 days after study treatment administration.; High-risk Non-ST-Elevation Myocardial Infarction (NSTEMI), within 2 days after study treatment administration.; NSTEMI with peak cardiac troponin greater than 10 times upper limit of normal, within 2 days after study drug administration.; None of the above	Total duration: up to 7 days
Occurrence of Type 3 or 5 treatment-emergent bleeding events according to the Bleeding Academic Research Consortium (BARC) definition	The number of: Type 3 treatment-emergent bleeding events and; Type 5 treatment-emergent bleeding events will be assessed according to the Bleeding Academic Research Consortium (BARC) definition (Mehran et al. 2011), within 2 days after study treatment administration. The Bleeding Academic Research Consortium (BARC) definitions are: Type 3, bleeding is divided into 3 categories, a through c, and includes clinical, laboratory, and/or imaging evidence of bleeding with specific healthcare provider responses.; Type 5, bleeding is fatal.	Total duration: up to 2 days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Occurrence of death, non-fatal acute myocardial infarction, hospitalization or unplanned emergency department visit for heart failure (Composite endpoint)	Occurrence death, non-fatal acute myocardial infarction, hospitalization or unplanned emergency department visit for heart failure within 30 days after any self-administration.	Total duration: up to 30 days

Collaborators and Investigators

• Sponsor: Viatris Innovation GmbH
• Investigators: Study Director: Clinical Trials, Viatris Innovation GmbH

Publications and helpful links

General Publications

• Mehran R, Rao SV, Bhatt DL, Gibson CM, Caixeta A, Eikelboom J, Kaul S, Wiviott SD, Menon V, Nikolsky E, Serebruany V, Valgimigli M, Vranckx P, Taggart D, Sabik JF, Cutlip DE, Krucoff MW, Ohman EM, Steg PG, White H. Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium. Circulation. 2011 Jun 14;123(23):2736-47. doi: 10.1161/CIRCULATIONAHA.110.009449. No abstract available.
• Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction. Fourth Universal Definition of Myocardial Infarction (2018). J Am Coll Cardiol. 2018 Oct 30;72(18):2231-2264. doi: 10.1016/j.jacc.2018.08.1038. Epub 2018 Aug 25. No abstract available.

Study record dates

Study Major Dates

• Study Start (Actual): August 14, 2021
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026

Study Registration Dates

• First Submitted: June 28, 2021
• First Submitted That Met QC Criteria: July 7, 2021
• First Posted (Actual): July 12, 2021

Study Record Updates

• Last Update Posted (Actual): May 22, 2026
• Last Update Submitted That Met QC Criteria: May 19, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Keywords: Platelet Aggregation Inhibitors
• Additional Relevant MeSH Terms: Vascular Diseases; Cardiovascular Diseases; Pathologic Processes; Heart Diseases; Necrosis; Myocardial Ischemia; Ischemia; Myocardial Infarction; Infarction; selatogrel
• Other Study ID Numbers: ID-076A301; 2020-000983-41 (EudraCT Number); 2023-505438-85-00 (Ctis)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: Yes
• Studies a U.S. FDA-regulated device product: Yes
• product manufactured in and exported from the U.S.: No