- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05256225
Testing the Addition of Trastuzumab or Trastuzumab/Pertuzumab to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma
A Phase II/III Study of Paclitaxel/Carboplatin Alone or Combined With Either Trastuzumab and Hyaluronidase-oysk (HERCEPTIN HYLECTA) or Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf (PHESGO) in HER2 Positive, Stage I-IV Endometrial Serous Carcinoma or Carcinosarcoma
Study Overview
Status
Detailed Description
PRIMARY OBJECTIVES:
I. To evaluate the efficacy of trastuzumab and hyaluronidase-oysk (HERCEPTIN HYLECTA) and pertuzumab, trastuzumab, and hyaluronidase-zzxf (PHESGO) in combination with paclitaxel/carboplatin in patients with HER2 positive endometrial serous carcinoma or carcinosarcoma. (Phase II) II. To evaluate the efficacy of trastuzumab and hyaluronidase-oysk (HERCEPTIN HYLECTA) and pertuzumab, trastuzumab, and hyaluronidase-zzxf (PHESGO) in combination with paclitaxel/carboplatin in patients with HER2 positive endometrial serous carcinoma or carcinosarcoma. (Phase III)
SECONDARY OBJECTIVES:
I. To evaluate the overall response rate (ORR) in patients with measurable disease.
II. To evaluate the duration of objective response in patients with measurable disease as assessed by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1.
III. To determine the nature, frequency and degree of toxicity as assessed by Common Terminology Criteria for Adverse Events (CTCAE) version (v.) 5.0 for each treatment arm.
IV. To compare quality of life (QOL), as measured by Functional Assessment of Cancer Therapy - Endometrial Trial Outcome Index (FACT-En-TOI), in the experimental versus control arms.
V. To compare patient-reported treatment-associated symptoms (diarrhea and rash) as measured with the Patient Reported Outcomes (PRO) - CTCAE, patient-reported fatigue as measured with the Patient Reported Outcomes Measurement Information System (PROMIS)-Fatigue short form, and other concerning side effects of treatment as measured by the item 'bothered by side effect', in the FACT-En TOI, respectively, in the experimental and control arms.
VI. To assess the correlation of HER2 immunohistochemistry (IHC) expression and in situ hybridization (ISH) amplification with clinical outcome and response to HER2 targeted therapies.
EXPLORATORY OBJECTIVE:
I. To explore time to sustained deterioration in quality of life, as measured by a drop in the FACT-En-TOI by 6 or more points lasting for more than one PRO time point, in the experimental and control arms.
OUTLINE: Patients are randomized to 1 of 3 arms.
ARM I: Patients receive paclitaxel intravenously (IV) over 3 hours and carboplatin IV over 30-60 minutes on day 1 of each cycle. Treatment repeats every 3 weeks for 6 cycles in the absence of disease progression or unacceptable toxicity. Patients with stable disease (SD) or partial response (PR) who still have measurable disease after completion of cycle 6 may receive 4 additional cycles of this treatment at the discretion of the treating physician.
ARM II: Patients receive paclitaxel IV over 3 hours, carboplatin IV over 30-60 minutes, and trastuzumab/hyaluronidase-oysk subcutaneously (SC) over 2-5 minutes on day 1 of each cycle. Treatment repeats every 3 weeks for 6 cycles in the absence of disease progression or unacceptable toxicity. Patients with SD or PR who still have measurable disease after completion of cycle 6 may receive 4 additional cycles of this treatment at the discretion of the treating physician.
MAINTENANCE: Patients receive trastuzumab/hyaluronidase-oysk SC over 2-5 minutes on day 1 of each cycle. Cycles repeat every 3 weeks for up to 1 year in the absence of disease progression or unacceptable toxicity. Patients with SD or PR may continue maintenance therapy for up to 3 years from the start of treatment.
ARM III: Patients receive paclitaxel IV over 3 hours, carboplatin IV over 30-60 minutes, and pertuzumab/trastuzumab/hyaluronidase-zzxf SC over 5-8 minutes on day 1 of each cycle. Treatment repeats every 3 weeks for 6 cycles in the absence of disease progression or unacceptable toxicity. Patients with SD or PR who still have measurable disease after completion of cycle 6 may receive 4 additional cycles of this treatment at the discretion of the treating physician.
MAINTENANCE: Patients receive pertuzumab/trastuzumab/ hyaluronidase-zzxf SC over 5 minutes on day 1. Cycles repeat every 3 weeks for up to 1 year in absence of disease progression or unacceptable toxicity. Patients with SD or PR may continue maintenance for up to 3 years from the start of treatment.
Patients undergo echocardiogram (ECHO) or multigated acquisition scan (MUGA) scan at end of treatment and every 6 months for 2 years.
After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.
Study Type
Enrollment (Estimated)
Phase
- Phase 2
- Phase 3
Contacts and Locations
Study Locations
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San Juan, Puerto Rico, 00927
- Recruiting
- Centro Comprensivo de Cancer de UPR
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Principal Investigator:
- Luis J. Santos Reyes
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Contact:
- Site Public Contact
- Phone Number: 412-339-5294
- Email: Roster@nrgoncology.org
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Alabama
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Birmingham, Alabama, United States, 35233
- Recruiting
- University of Alabama at Birmingham Cancer Center
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Contact:
- Site Public Contact
- Phone Number: 205-934-0220
- Email: tmyrick@uab.edu
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Principal Investigator:
- Michael D. Toboni
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Arizona
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Tucson, Arizona, United States, 85719
- Recruiting
- Banner University Medical Center - Tucson
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Principal Investigator:
- Setsuko K. Chambers
-
Contact:
- Site Public Contact
- Email: UACC-IIT@uacc.arizona.edu
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Tucson, Arizona, United States, 85719
- Recruiting
- University of Arizona Cancer Center-North Campus
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Principal Investigator:
- Setsuko K. Chambers
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Contact:
- Site Public Contact
- Email: UACC-IIT@uacc.arizona.edu
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Arkansas
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Little Rock, Arkansas, United States, 72205
- Recruiting
- University of Arkansas for Medical Sciences
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Contact:
- Site Public Contact
- Phone Number: 501-686-8274
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Principal Investigator:
- Heather R. Williams
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California
-
Auburn, California, United States, 95602
- Recruiting
- Sutter Auburn Faith Hospital
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Principal Investigator:
- John K. Chan
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Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
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Berkeley, California, United States, 94704
- Recruiting
- Alta Bates Summit Medical Center-Herrick Campus
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Principal Investigator:
- John K. Chan
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
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Concord, California, United States, 94520
- Recruiting
- John Muir Medical Center-Concord Campus
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Principal Investigator:
- Babak Edraki
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Contact:
- Site Public Contact
- Phone Number: 925-674-2580
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Duarte, California, United States, 91010
- Recruiting
- City of Hope Comprehensive Cancer Center
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Contact:
- Site Public Contact
- Phone Number: 800-826-4673
- Email: becomingapatient@coh.org
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Principal Investigator:
- Joshua G. Cohen
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Huntington Beach, California, United States, 92648
- Recruiting
- City of Hope at Huntington Beach
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Contact:
- Site Public Contact
- Phone Number: 877-467-3411
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Principal Investigator:
- Joshua G. Cohen
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Irvine, California, United States, 92618
- Recruiting
- Kaiser Permanente-Irvine
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Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
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Principal Investigator:
- Scott E. Lentz
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Irvine, California, United States, 92618
- Recruiting
- City of Hope at Irvine Lennar
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Contact:
- Site Public Contact
- Phone Number: 877-467-3411
-
Principal Investigator:
- Joshua G. Cohen
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Long Beach, California, United States, 90813
- Recruiting
- City of Hope at Long Beach Elm
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Contact:
- Site Public Contact
- Phone Number: 877-467-3411
-
Principal Investigator:
- Joshua G. Cohen
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Los Angeles, California, United States, 90027
- Recruiting
- Kaiser Permanente Los Angeles Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
-
Principal Investigator:
- Scott E. Lentz
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Modesto, California, United States, 95355
- Recruiting
- Memorial Medical Center
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Principal Investigator:
- John K. Chan
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
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Mountain View, California, United States, 94040
- Recruiting
- Palo Alto Medical Foundation-Gynecologic Oncology
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Principal Investigator:
- John K. Chan
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
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Riverside, California, United States, 92505
- Recruiting
- Kaiser Permanente-Riverside
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Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
-
Principal Investigator:
- Scott E. Lentz
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Roseville, California, United States, 95661
- Recruiting
- Sutter Roseville Medical Center
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Principal Investigator:
- John K. Chan
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
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Sacramento, California, United States, 95817
- Recruiting
- University of California Davis Comprehensive Cancer Center
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Contact:
- Site Public Contact
- Phone Number: 916-734-3089
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Principal Investigator:
- Rebecca A. Brooks
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San Francisco, California, United States, 94115
- Recruiting
- California Pacific Medical Center-Pacific Campus
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Principal Investigator:
- John K. Chan
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
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Sunnyvale, California, United States, 94086
- Recruiting
- Palo Alto Medical Foundation-Sunnyvale
-
Principal Investigator:
- John K. Chan
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
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Upland, California, United States, 91786
- Recruiting
- City of Hope Upland
-
Contact:
- Site Public Contact
- Phone Number: 800-826-4673
- Email: becomingapatient@coh.org
-
Principal Investigator:
- Joshua G. Cohen
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Walnut Creek, California, United States, 94598
- Recruiting
- John Muir Medical Center-Walnut Creek
-
Principal Investigator:
- Babak Edraki
-
Contact:
- Site Public Contact
- Phone Number: 925-941-4246
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Colorado
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Aurora, Colorado, United States, 80045
- Recruiting
- UCHealth University of Colorado Hospital
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Principal Investigator:
- Marisa R. Moroney
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Contact:
- Site Public Contact
- Phone Number: 720-848-0650
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Denver, Colorado, United States, 80206
- Recruiting
- UCHealth - Cherry Creek
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Principal Investigator:
- Marisa R. Moroney
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Contact:
- Site Public Contact
- Phone Number: 412-339-5294
- Email: Roster@nrgoncology.org
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Greeley, Colorado, United States, 80631
- Recruiting
- North Colorado Medical Center
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Principal Investigator:
- Robin A. Lacour
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Contact:
- Site Public Contact
- Phone Number: 970-810-3046
- Email: BMDACCResearchCOMailbox@bannerhealth.com
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Highlands Ranch, Colorado, United States, 80129
- Recruiting
- UCHealth Highlands Ranch Hospital
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Principal Investigator:
- Marisa R. Moroney
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Contact:
- Site Public Contact
- Phone Number: 720-848-0650
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Loveland, Colorado, United States, 80539
- Recruiting
- McKee Medical Center
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Principal Investigator:
- Robin A. Lacour
-
Contact:
- Site Public Contact
- Phone Number: 970-810-3046
- Email: BMDACCResearchCOMailbox@bannerhealth.com
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Connecticut
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Danbury, Connecticut, United States, 06810
- Recruiting
- Danbury Hospital
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Contact:
- Site Public Contact
- Phone Number: 203-739-8074
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Principal Investigator:
- Wenli Gao
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Derby, Connecticut, United States, 06418
- Recruiting
- Smilow Cancer Hospital-Derby Care Center
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Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Alessandro D. Santin
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Fairfield, Connecticut, United States, 06824
- Recruiting
- Smilow Cancer Hospital Care Center-Fairfield
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Alessandro D. Santin
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Glastonbury, Connecticut, United States, 06033
- Recruiting
- Smilow Cancer Hospital Care Center at Glastonbury
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Alessandro D. Santin
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Greenwich, Connecticut, United States, 06830
- Recruiting
- Smilow Cancer Hospital Care Center at Greenwich
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Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Alessandro D. Santin
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Guilford, Connecticut, United States, 06437
- Recruiting
- Smilow Cancer Hospital Care Center - Guilford
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Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Alessandro D. Santin
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Hartford, Connecticut, United States, 06105
- Recruiting
- Smilow Cancer Hospital Care Center at Saint Francis
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Alessandro D. Santin
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New Haven, Connecticut, United States, 06520
- Recruiting
- Yale University
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
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Principal Investigator:
- Alessandro D. Santin
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North Haven, Connecticut, United States, 06473
- Recruiting
- Yale-New Haven Hospital North Haven Medical Center
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Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
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Principal Investigator:
- Alessandro D. Santin
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Norwalk, Connecticut, United States, 06856
- Recruiting
- Norwalk Hospital
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Contact:
- Site Public Contact
- Phone Number: 203-852-2996
- Email: jennifer.long@norwalkhealth.org
-
Principal Investigator:
- Richard C. Frank
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Stamford, Connecticut, United States, 06902
- Recruiting
- Smilow Cancer Hospital Care Center at Long Ridge
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Alessandro D. Santin
-
Torrington, Connecticut, United States, 06790
- Recruiting
- Smilow Cancer Hospital-Torrington Care Center
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Alessandro D. Santin
-
Trumbull, Connecticut, United States, 06611
- Recruiting
- Smilow Cancer Hospital Care Center-Trumbull
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Alessandro D. Santin
-
Waterbury, Connecticut, United States, 06708
- Recruiting
- Smilow Cancer Hospital-Waterbury Care Center
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Alessandro D. Santin
-
Waterford, Connecticut, United States, 06385
- Recruiting
- Smilow Cancer Hospital Care Center - Waterford
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Alessandro D. Santin
-
-
Delaware
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Newark, Delaware, United States, 19713
- Recruiting
- Helen F Graham Cancer Center
-
Principal Investigator:
- Gregory A. Masters
-
Contact:
- Site Public Contact
- Phone Number: 302-623-4450
- Email: lbarone@christianacare.org
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Newark, Delaware, United States, 19713
- Recruiting
- Medical Oncology Hematology Consultants PA
-
Principal Investigator:
- Gregory A. Masters
-
Contact:
- Site Public Contact
- Phone Number: 302-623-4450
- Email: lbarone@christianacare.org
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-
District of Columbia
-
Washington, District of Columbia, United States, 20016
- Recruiting
- Sibley Memorial Hospital
-
Contact:
- Site Public Contact
- Phone Number: 202-243-2373
- Email: jquiver1@jhmi.edu
-
Principal Investigator:
- Amanda N. Fader
-
Washington, District of Columbia, United States, 20037
- Recruiting
- George Washington University Medical Center
-
Principal Investigator:
- Nicole P. Chappell
-
Contact:
- Site Public Contact
- Phone Number: 202-741-2981
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-
Florida
-
Orlando, Florida, United States, 32803
- Recruiting
- AdventHealth Orlando
-
Contact:
- Site Public Contact
- Phone Number: 407-303-2090
- Email: FH.Cancer.Research@flhosp.org
-
Principal Investigator:
- Nathalie D. McKenzie
-
Sarasota, Florida, United States, 34236
- Recruiting
- Florida Cancer Specialists - Sarasota Downtown
-
Principal Investigator:
- Beverly Long
-
Contact:
- Site Public Contact
- Phone Number: 941-957-1000
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Sarasota, Florida, United States, 34239
- Recruiting
- Sarasota Memorial Hospital
-
Principal Investigator:
- Beverly Long
-
Contact:
- Site Public Contact
- Phone Number: 941-917-2225
-
Sarasota, Florida, United States, 34239
- Recruiting
- First Physicians Group-Sarasota
-
Principal Investigator:
- Beverly Long
-
Contact:
- Site Public Contact
- Phone Number: 941-917-8383
-
Venice, Florida, United States, 34292
- Recruiting
- Florida Cancer Specialists - Venice Healthpark
-
Contact:
- Site Public Contact
- Phone Number: 412-339-5294
- Email: Roster@nrgoncology.org
-
Principal Investigator:
- Beverly Long
-
-
Georgia
-
Atlanta, Georgia, United States, 30322
- Recruiting
- Emory University Hospital/Winship Cancer Institute
-
Contact:
- Site Public Contact
- Phone Number: 404-778-1868
-
Principal Investigator:
- Namita Khanna
-
Atlanta, Georgia, United States, 30303
- Recruiting
- Grady Health System
-
Contact:
- Site Public Contact
- Phone Number: 404-489-9164
-
Principal Investigator:
- Namita Khanna
-
Atlanta, Georgia, United States, 30308
- Recruiting
- Emory University Hospital Midtown
-
Contact:
- Site Public Contact
- Phone Number: 888-946-7447
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Principal Investigator:
- Namita Khanna
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Atlanta, Georgia, United States, 30342
- Recruiting
- Emory Saint Joseph's Hospital
-
Contact:
- Site Public Contact
- Phone Number: 404-851-7115
-
Principal Investigator:
- Namita Khanna
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Augusta, Georgia, United States, 30912
- Recruiting
- Augusta University Medical Center
-
Principal Investigator:
- Sharad A. Ghamande
-
Contact:
- Site Public Contact
- Phone Number: 706-721-2388
- Email: ga_cares@augusta.edu
-
Savannah, Georgia, United States, 31405
- Recruiting
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
-
Contact:
- Site Public Contact
- Phone Number: 912-819-5704
- Email: underberga@sjchs.org
-
Principal Investigator:
- Sarah E. Gill
-
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Hawaii
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Honolulu, Hawaii, United States, 96826
- Recruiting
- Kapiolani Medical Center for Women and Children
-
Contact:
- Site Public Contact
- Phone Number: 808-983-6090
-
Principal Investigator:
- Michael E. Carney
-
Honolulu, Hawaii, United States, 96813
- Recruiting
- Queen's Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 808-545-8548
-
Principal Investigator:
- Michael E. Carney
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Idaho
-
Boise, Idaho, United States, 83712
- Recruiting
- Saint Luke's Cancer Institute - Boise
-
Contact:
- Site Public Contact
- Phone Number: 208-381-2774
- Email: eslinget@slhs.org
-
Principal Investigator:
- Nitya Alluri
-
Boise, Idaho, United States, 83706
- Recruiting
- Saint Alphonsus Cancer Care Center-Boise
-
Contact:
- Site Public Contact
- Phone Number: 734-712-3671
- Email: stephanie.couch@stjoeshealth.org
-
Principal Investigator:
- John M. Schallenkamp
-
Caldwell, Idaho, United States, 83605
- Recruiting
- Saint Alphonsus Cancer Care Center-Caldwell
-
Contact:
- Site Public Contact
- Phone Number: 734-712-3671
- Email: stephanie.couch@stjoeshealth.org
-
Principal Investigator:
- John M. Schallenkamp
-
Coeur d'Alene, Idaho, United States, 83814
- Recruiting
- Kootenai Health - Coeur d'Alene
-
Principal Investigator:
- John M. Schallenkamp
-
Contact:
- Site Public Contact
- Phone Number: 406-969-6060
- Email: mccinfo@mtcancer.org
-
Fruitland, Idaho, United States, 83619
- Recruiting
- Saint Luke's Cancer Institute - Fruitland
-
Contact:
- Site Public Contact
- Phone Number: 208-381-2774
- Email: eslinget@slhs.org
-
Principal Investigator:
- Nitya Alluri
-
Meridian, Idaho, United States, 83642
- Recruiting
- Saint Luke's Cancer Institute - Meridian
-
Contact:
- Site Public Contact
- Phone Number: 208-381-2774
- Email: eslinget@slhs.org
-
Principal Investigator:
- Nitya Alluri
-
Nampa, Idaho, United States, 83686
- Recruiting
- Saint Luke's Cancer Institute - Nampa
-
Contact:
- Site Public Contact
- Phone Number: 208-381-2774
- Email: eslinget@slhs.org
-
Principal Investigator:
- Nitya Alluri
-
Nampa, Idaho, United States, 83687
- Recruiting
- Saint Alphonsus Cancer Care Center-Nampa
-
Principal Investigator:
- John M. Schallenkamp
-
Contact:
- Site Public Contact
- Phone Number: 406-969-6060
- Email: mccinfo@mtcancer.org
-
Post Falls, Idaho, United States, 83854
- Recruiting
- Kootenai Clinic Cancer Services - Post Falls
-
Principal Investigator:
- John M. Schallenkamp
-
Contact:
- Site Public Contact
- Phone Number: 406-969-6060
- Email: mccinfo@mtcancer.org
-
Sandpoint, Idaho, United States, 83864
- Recruiting
- Kootenai Cancer Clinic
-
Principal Investigator:
- John M. Schallenkamp
-
Contact:
- Site Public Contact
- Phone Number: 406-969-6060
- Email: mccinfo@mtcancer.org
-
Twin Falls, Idaho, United States, 83301
- Recruiting
- Saint Luke's Cancer Institute - Twin Falls
-
Contact:
- Site Public Contact
- Phone Number: 208-381-2774
- Email: eslinget@slhs.org
-
Principal Investigator:
- Nitya Alluri
-
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Illinois
-
Arlington Heights, Illinois, United States, 60005
- Recruiting
- Northwest Community Hospital
-
Principal Investigator:
- Kathryn A. Mills
-
Contact:
- Site Public Contact
- Phone Number: 847-618-4968
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Aurora, Illinois, United States, 60504
- Recruiting
- Rush - Copley Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 630-978-6212
- Email: Cancer.Research@rushcopley.com
-
Principal Investigator:
- Pratima Chalasani
-
Centralia, Illinois, United States, 62801
- Recruiting
- Centralia Oncology Clinic
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-876-4762
- Email: morganthaler.jodi@mhsil.com
-
Chicago, Illinois, United States, 60612
- Recruiting
- Rush University Medical Center
-
Principal Investigator:
- Summer B. Dewdney
-
Contact:
- Site Public Contact
- Phone Number: 312-942-5498
- Email: clinical_trials@rush.edu
-
Chicago, Illinois, United States, 60637
- Recruiting
- University of Chicago Comprehensive Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 773-702-8222
- Email: cancerclinicaltrials@bsd.uchicago.edu
-
Principal Investigator:
- Katherine C. Kurnit
-
Chicago, Illinois, United States, 60611
- Recruiting
- Northwestern University
-
Contact:
- Site Public Contact
- Phone Number: 312-695-1301
- Email: cancer@northwestern.edu
-
Principal Investigator:
- Emily Hinchcliff
-
Chicago, Illinois, United States, 60612
- Recruiting
- John H Stroger Jr Hospital of Cook County
-
Contact:
- Site Public Contact
- Phone Number: 312-864-5204
-
Principal Investigator:
- Thomas E. Lad
-
Danville, Illinois, United States, 61832
- Recruiting
- Carle at The Riverfront
-
Contact:
- Site Public Contact
- Phone Number: 800-446-5532
- Email: Research@carle.com
-
Principal Investigator:
- Pratima Chalasani
-
DeKalb, Illinois, United States, 60115
- Recruiting
- Northwestern Medicine Cancer Center Kishwaukee
-
Contact:
- Site Public Contact
- Phone Number: 630-352-5360
- Email: Donald.Smith3@nm.org
-
Principal Investigator:
- Emily Hinchcliff
-
Decatur, Illinois, United States, 62526
- Recruiting
- Cancer Care Specialists of Illinois - Decatur
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-876-4762
- Email: morganthaler.jodi@mhsil.com
-
Decatur, Illinois, United States, 62526
- Recruiting
- Decatur Memorial Hospital
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-876-4762
- Email: morganthaler.jodi@mhsil.com
-
Effingham, Illinois, United States, 62401
- Recruiting
- Carle Physician Group-Effingham
-
Contact:
- Site Public Contact
- Phone Number: 800-446-5532
- Email: Research@carle.com
-
Principal Investigator:
- Pratima Chalasani
-
Effingham, Illinois, United States, 62401
- Recruiting
- Crossroads Cancer Center
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-876-4762
- Email: morganthaler.jodi@mhsil.com
-
Evanston, Illinois, United States, 60201
- Recruiting
- NorthShore University HealthSystem-Evanston Hospital
-
Contact:
- Site Public Contact
- Phone Number: 847-570-2109
-
Principal Investigator:
- Mary T. Jenkins Vogel
-
Geneva, Illinois, United States, 60134
- Recruiting
- Northwestern Medicine Cancer Center Delnor
-
Contact:
- Site Public Contact
- Phone Number: 630-352-5360
- Email: Donald.Smith3@nm.org
-
Principal Investigator:
- Emily Hinchcliff
-
Glenview, Illinois, United States, 60026
- Recruiting
- NorthShore University HealthSystem-Glenbrook Hospital
-
Contact:
- Site Public Contact
- Phone Number: 847-570-2109
-
Principal Investigator:
- Mary T. Jenkins Vogel
-
Highland Park, Illinois, United States, 60035
- Recruiting
- NorthShore University HealthSystem-Highland Park Hospital
-
Contact:
- Site Public Contact
- Phone Number: 847-570-2109
-
Principal Investigator:
- Mary T. Jenkins Vogel
-
Hinsdale, Illinois, United States, 60521
- Recruiting
- Sudarshan K Sharma MD Limited-Gynecologic Oncology
-
Contact:
- Site Public Contact
- Phone Number: 630-856-6757
-
Principal Investigator:
- Sudarshan K. Sharma
-
Lake Forest, Illinois, United States, 60045
- Recruiting
- Northwestern Medicine Lake Forest Hospital
-
Contact:
- Site Public Contact
- Email: cancertrials@northwestern.edu
-
Principal Investigator:
- Emily Hinchcliff
-
Mattoon, Illinois, United States, 61938
- Recruiting
- Carle Physician Group-Mattoon/Charleston
-
Contact:
- Site Public Contact
- Phone Number: 800-446-5532
- Email: Research@carle.com
-
Principal Investigator:
- Pratima Chalasani
-
New Lenox, Illinois, United States, 60451
- Recruiting
- UC Comprehensive Cancer Center at Silver Cross
-
Contact:
- Site Public Contact
- Phone Number: 773-702-8222
- Email: cancerclinicaltrials@bsd.uchicago.edu
-
Principal Investigator:
- Katherine C. Kurnit
-
O'Fallon, Illinois, United States, 62269
- Recruiting
- Cancer Care Center of O'Fallon
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-876-4762
- Email: morganthaler.jodi@mhsil.com
-
Orland Park, Illinois, United States, 60462
- Recruiting
- University of Chicago Medicine-Orland Park
-
Contact:
- Site Public Contact
- Phone Number: 773-702-8222
- Email: cancerclinicaltrials@bsd.uchicago.edu
-
Principal Investigator:
- Katherine C. Kurnit
-
Springfield, Illinois, United States, 62702
- Recruiting
- Southern Illinois University School of Medicine
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-545-7929
-
Springfield, Illinois, United States, 62702
- Recruiting
- Springfield Clinic
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 800-444-7541
-
Springfield, Illinois, United States, 62781
- Recruiting
- Memorial Medical Center
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-528-7541
- Email: pallante.beth@mhsil.com
-
Urbana, Illinois, United States, 61801
- Recruiting
- Carle Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-446-5532
- Email: Research@carle.com
-
Principal Investigator:
- Pratima Chalasani
-
Warrenville, Illinois, United States, 60555
- Recruiting
- Northwestern Medicine Cancer Center Warrenville
-
Contact:
- Site Public Contact
- Phone Number: 630-352-5360
- Email: Donald.Smith3@nm.org
-
Principal Investigator:
- Emily Hinchcliff
-
Yorkville, Illinois, United States, 60560
- Recruiting
- Rush-Copley Healthcare Center
-
Contact:
- Site Public Contact
- Phone Number: 630-978-6212
- Email: Cancer.Research@rushcopley.com
-
Principal Investigator:
- Pratima Chalasani
-
-
Indiana
-
Crown Point, Indiana, United States, 46307
- Recruiting
- Northwest Cancer Center - Main Campus
-
Contact:
- Site Public Contact
- Phone Number: 219-310-2550
-
Principal Investigator:
- Pratima Chalasani
-
Dyer, Indiana, United States, 46311
- Recruiting
- Northwest Oncology LLC
-
Contact:
- Site Public Contact
- Phone Number: 219-924-8178
-
Principal Investigator:
- Pratima Chalasani
-
Goshen, Indiana, United States, 46526
- Recruiting
- Goshen Center for Cancer Care
-
Contact:
- Site Public Contact
- Phone Number: 574-364-2973
- Email: cccois@goshenhealth.com
-
Principal Investigator:
- Pamela J. Stone
-
Hobart, Indiana, United States, 46342
- Recruiting
- Northwest Cancer Center - Hobart
-
Contact:
- Site Public Contact
- Phone Number: 219-947-1795
-
Principal Investigator:
- Pratima Chalasani
-
Hobart, Indiana, United States, 46342
- Recruiting
- Saint Mary Medical Center
-
Principal Investigator:
- Pratima Chalasani
-
Contact:
- Site Public Contact
- Phone Number: 219-836-6875
- Email: CancerResearch@COMHS.org
-
Indianapolis, Indiana, United States, 46260
- Recruiting
- Ascension Saint Vincent Indianapolis Hospital
-
Contact:
- Site Public Contact
- Phone Number: 317-338-2194
- Email: research@stvincent.org
-
Principal Investigator:
- Megan E. Buechel
-
Indianapolis, Indiana, United States, 46202
- Recruiting
- Indiana University/Melvin and Bren Simon Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 317-278-5632
- Email: iutrials@iu.edu
-
Principal Investigator:
- Jessica E. Parker
-
Indianapolis, Indiana, United States, 46237
- Recruiting
- Franciscan Health Indianapolis
-
Contact:
- Site Public Contact
- Phone Number: 317-528-7060
-
Principal Investigator:
- Harsha Ranganath
-
Indianapolis, Indiana, United States, 46312
- Recruiting
- Saint Catherine Hospital
-
Principal Investigator:
- Pratima Chalasani
-
Contact:
- Site Public Contact
- Phone Number: 412-339-5294
- Email: Roster@nrgoncology.org
-
Lafayette, Indiana, United States, 47905
- Recruiting
- Franciscan Saint Elizabeth Health - Lafayette East
-
Contact:
- Site Public Contact
- Phone Number: 888-823-5923
- Email: ctsucontact@westat.com
-
Principal Investigator:
- Harsha Ranganath
-
Mooresville, Indiana, United States, 46158
- Recruiting
- Franciscan Health Mooresville
-
Principal Investigator:
- Harsha Ranganath
-
Contact:
- Site Public Contact
- Phone Number: 317-834-3603
-
Munster, Indiana, United States, 46321
- Recruiting
- The Community Hospital
-
Contact:
- Site Public Contact
- Phone Number: 219-836-3349
-
Principal Investigator:
- Pratima Chalasani
-
Munster, Indiana, United States, 46321
- Recruiting
- Women's Diagnostic Center - Munster
-
Contact:
- Site Public Contact
- Phone Number: 219-934-8869
- Email: mnicholson@comhs.org
-
Principal Investigator:
- Pratima Chalasani
-
South Bend, Indiana, United States, 46601
- Recruiting
- Memorial Hospital of South Bend
-
Contact:
- Site Public Contact
- Phone Number: 800-284-7370
-
Principal Investigator:
- Nonyem A. Onujiogu
-
Valparaiso, Indiana, United States, 46383
- Recruiting
- Northwest Cancer Center - Valparaiso
-
Principal Investigator:
- Pratima Chalasani
-
Contact:
- Site Public Contact
- Phone Number: 219-836-6875
- Email: CancerResearch@COMHS.org
-
-
Iowa
-
Ames, Iowa, United States, 50010
- Recruiting
- Mary Greeley Medical Center
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-956-4132
-
Ames, Iowa, United States, 50010
- Recruiting
- McFarland Clinic - Ames
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-239-4734
- Email: ksoder@mcfarlandclinic.com
-
Fort Dodge, Iowa, United States, 50501
- Recruiting
- McFarland Clinic - Trinity Cancer Center
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-956-4132
-
Iowa City, Iowa, United States, 52242
- Recruiting
- University of Iowa/Holden Comprehensive Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-237-1225
-
Principal Investigator:
- David P. Bender
-
Jefferson, Iowa, United States, 50129
- Recruiting
- McFarland Clinic - Jefferson
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-956-4132
-
Marshalltown, Iowa, United States, 50158
- Recruiting
- McFarland Clinic - Marshalltown
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-956-4132
-
-
Kentucky
-
Edgewood, Kentucky, United States, 41017
- Recruiting
- Saint Elizabeth Healthcare Edgewood
-
Contact:
- Site Public Contact
- Phone Number: 859-301-4730
- Email: barbara.logan@stelizabeth.com
-
Principal Investigator:
- Robert Neff
-
Lexington, Kentucky, United States, 40503
- Recruiting
- Baptist Health Lexington
-
Contact:
- Site Public Contact
- Phone Number: 859-260-6425
-
Principal Investigator:
- Hope Cottrill
-
Louisville, Kentucky, United States, 40207
- Recruiting
- Baptist Health Louisville
-
Contact:
- Site Public Contact
- Phone Number: 502-897-8592
- Email: Cbcresearch@bhsi.com
-
Principal Investigator:
- Hope Cottrill
-
-
Louisiana
-
Baton Rouge, Louisiana, United States, 70805
- Recruiting
- LSU Health Baton Rouge-North Clinic
-
Contact:
- Site Public Contact
- Phone Number: 225-765-7659
- Email: research@ololrmc.com
-
Principal Investigator:
- Marshall P. Stagg
-
Baton Rouge, Louisiana, United States, 70809
- Recruiting
- Our Lady of the Lake Physicians Group - Medical Oncology
-
Contact:
- Site Public Contact
- Phone Number: 225-765-7659
- Email: research@ololrmc.com
-
Principal Investigator:
- Marshall P. Stagg
-
Baton Rouge, Louisiana, United States, 70817
- Recruiting
- Our Lady of the Lake Medical Oncology
-
Contact:
- Site Public Contact
- Phone Number: 225-765-7659
- Email: research@ololrmc.com
-
Principal Investigator:
- Marshall P. Stagg
-
Covington, Louisiana, United States, 70433
- Recruiting
- Ochsner Hematology Oncology North Shore - Covington (West Region)
-
Principal Investigator:
- Chad A. Hamilton
-
Contact:
- Site Public Contact
- Phone Number: 985-809-5668
- Email: Cheryl.kesler@ochsner.org
-
Metairie, Louisiana, United States, 70006
- Recruiting
- East Jefferson General Hospital
-
Contact:
- Site Public Contact
- Phone Number: 504-210-3539
- Email: emede1@lsuhsc.edu
-
Principal Investigator:
- Tara Castellano
-
New Orleans, Louisiana, United States, 70121
- Recruiting
- Ochsner Medical Center Jefferson
-
Principal Investigator:
- Chad A. Hamilton
-
Contact:
- Site Public Contact
- Phone Number: 504-842-8084
- Email: Elisemarie.curry@ochsner.org
-
New Orleans, Louisiana, United States, 70112
- Recruiting
- University Medical Center New Orleans
-
Contact:
- Site Public Contact
- Phone Number: 504-210-3539
- Email: emede1@lsuhsc.edu
-
Principal Investigator:
- Tara Castellano
-
New Orleans, Louisiana, United States, 70115
- Recruiting
- Ochsner Baptist Medical Center
-
Principal Investigator:
- Chad A. Hamilton
-
Contact:
- Site Public Contact
- Phone Number: 504-842-8084
- Email: Elisemarie.curry@ochsner.org
-
-
Maine
-
Augusta, Maine, United States, 04330
- Recruiting
- Harold Alfond Center for Cancer Care
-
Contact:
- Site Public Contact
- Phone Number: 207-626-4855
-
Principal Investigator:
- Leslie S. Bradford
-
Scarborough, Maine, United States, 04074
- Recruiting
- Maine Medical Center- Scarborough Campus
-
Contact:
- Site Public Contact
- Phone Number: 207-396-8090
- Email: wrighd@mmc.org
-
Principal Investigator:
- Leslie S. Bradford
-
-
Maryland
-
Baltimore, Maryland, United States, 21287
- Recruiting
- Johns Hopkins University/Sidney Kimmel Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 410-955-8804
- Email: jhcccro@jhmi.edu
-
Principal Investigator:
- Amanda N. Fader
-
Baltimore, Maryland, United States, 21204
- Recruiting
- Greater Baltimore Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 443-849-3706
-
Principal Investigator:
- Kimberly L. Levinson
-
Baltimore, Maryland, United States, 21215
- Recruiting
- Sinai Hospital of Baltimore
-
Contact:
- Site Public Contact
- Phone Number: 410-601-6120
- Email: pridgely@lifebridgehealth.org
-
Principal Investigator:
- Pallavi P. Kumar
-
Bethesda, Maryland, United States, 20889-5600
- Recruiting
- Walter Reed National Military Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 301-319-2100
-
Principal Investigator:
- Neil T. Phippen
-
Westminster, Maryland, United States, 21157
- Recruiting
- William E Kahlert Regional Cancer Center/Sinai Hospital
-
Contact:
- Site Public Contact
- Phone Number: 410-871-6400
-
Principal Investigator:
- Pallavi P. Kumar
-
-
Massachusetts
-
Springfield, Massachusetts, United States, 01199
- Recruiting
- Baystate Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 413-794-3565
- Email: tamara.wrenn@baystatehealth.org
-
Principal Investigator:
- Tashanna K. Myers
-
-
Michigan
-
Ann Arbor, Michigan, United States, 48109
- Recruiting
- University of Michigan Comprehensive Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-865-1125
-
Principal Investigator:
- Jean H. Siedel
-
Battle Creek, Michigan, United States, 49017
- Recruiting
- Bronson Battle Creek
-
Contact:
- Site Public Contact
- Phone Number: 616-391-1230
- Email: crcwm-regulatory@crcwm.org
-
Principal Investigator:
- Kathleen J. Yost
-
Detroit, Michigan, United States, 48201
- Recruiting
- Wayne State University/Karmanos Cancer Institute
-
Contact:
- Site Public Contact
- Phone Number: 313-576-9790
- Email: ctoadmin@karmanos.org
-
Principal Investigator:
- Radhika P. Gogoi
-
Farmington Hills, Michigan, United States, 48334
- Recruiting
- Weisberg Cancer Treatment Center
-
Contact:
- Site Public Contact
- Phone Number: 313-576-9790
- Email: ctoadmin@karmanos.org
-
Principal Investigator:
- Radhika P. Gogoi
-
Farmington Hills, Michigan, United States, 48336
- Recruiting
- Beaumont Hospital - Farmington Hills
-
Contact:
- Site Public Contact
- Phone Number: 248-551-7695
-
Principal Investigator:
- Stefany Acosta-Torres
-
Grand Rapids, Michigan, United States, 49503
- Recruiting
- Spectrum Health at Butterworth Campus
-
Contact:
- Site Public Contact
- Phone Number: 616-391-1230
- Email: crcwm-regulatory@crcwm.org
-
Principal Investigator:
- Kathleen J. Yost
-
Grand Rapids, Michigan, United States, 49503
- Recruiting
- Trinity Health Grand Rapids Hospital
-
Contact:
- Site Public Contact
- Phone Number: 616-391-1230
- Email: crcwm-regulatory@crcwm.org
-
Principal Investigator:
- Kathleen J. Yost
-
Kalamazoo, Michigan, United States, 49007
- Recruiting
- Bronson Methodist Hospital
-
Contact:
- Site Public Contact
- Phone Number: 616-391-1230
- Email: crcwm-regulatory@crcwm.org
-
Principal Investigator:
- Kathleen J. Yost
-
Kalamazoo, Michigan, United States, 49007
- Recruiting
- West Michigan Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 616-391-1230
- Email: crcwm-regulatory@crcwm.org
-
Principal Investigator:
- Kathleen J. Yost
-
Kalamazoo, Michigan, United States, 49009
- Recruiting
- Ascension Borgess Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 616-391-1230
- Email: crcwm-regulatory@crcwm.org
-
Principal Investigator:
- Kathleen J. Yost
-
Muskegon, Michigan, United States, 49444
- Recruiting
- Trinity Health Muskegon Hospital
-
Contact:
- Site Public Contact
- Phone Number: 616-391-1230
- Email: crcwm-regulatory@crcwm.org
-
Principal Investigator:
- Kathleen J. Yost
-
Norton Shores, Michigan, United States, 49444
- Recruiting
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Principal Investigator:
- Kathleen J. Yost
-
Contact:
- Site Public Contact
- Phone Number: 616-391-1230
- Email: connie.szczepanek@crcwm.org
-
Reed City, Michigan, United States, 49677
- Recruiting
- Corewell Health Reed City Hospital
-
Contact:
- Site Public Contact
- Phone Number: 616-391-1230
- Email: crcwm-regulatory@crcwm.org
-
Principal Investigator:
- Kathleen J. Yost
-
Royal Oak, Michigan, United States, 48073
- Recruiting
- William Beaumont Hospital-Royal Oak
-
Contact:
- Site Public Contact
- Phone Number: 248-551-7695
-
Principal Investigator:
- Stefany Acosta-Torres
-
Saint Joseph, Michigan, United States, 49085
- Recruiting
- Marie Yeager Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 616-391-1230
- Email: crcwm-regulatory@crcwm.org
-
Principal Investigator:
- Kathleen J. Yost
-
Traverse City, Michigan, United States, 49684
- Recruiting
- Munson Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 616-391-1230
- Email: crcwm-regulatory@crcwm.org
-
Principal Investigator:
- Kathleen J. Yost
-
Troy, Michigan, United States, 48085
- Recruiting
- William Beaumont Hospital - Troy
-
Contact:
- Site Public Contact
- Phone Number: 248-551-7695
-
Principal Investigator:
- Stefany Acosta-Torres
-
Wyoming, Michigan, United States, 49519
- Recruiting
- University of Michigan Health - West
-
Contact:
- Site Public Contact
- Phone Number: 616-391-1230
- Email: crcwm-regulatory@crcwm.org
-
Principal Investigator:
- Kathleen J. Yost
-
-
Minnesota
-
Coon Rapids, Minnesota, United States, 55433
- Recruiting
- Mercy Hospital
-
Contact:
- Site Public Contact
- Phone Number: 952-993-1517
- Email: mmcorc@healthpartners.com
-
Principal Investigator:
- Jessica A. Thomes Pepin
-
Edina, Minnesota, United States, 55435
- Recruiting
- Fairview Southdale Hospital
-
Contact:
- Site Public Contact
- Phone Number: 952-993-1517
- Email: mmcorc@healthpartners.com
-
Principal Investigator:
- Jessica A. Thomes Pepin
-
Maplewood, Minnesota, United States, 55109
- Recruiting
- Minnesota Oncology Hematology PA-Maplewood
-
Contact:
- Site Public Contact
- Phone Number: 952-993-1517
- Email: mmcorc@healthpartners.com
-
Principal Investigator:
- Jessica A. Thomes Pepin
-
Minneapolis, Minnesota, United States, 55407
- Recruiting
- Abbott-Northwestern Hospital
-
Contact:
- Site Public Contact
- Phone Number: 952-993-1517
- Email: mmcorc@healthpartners.com
-
Principal Investigator:
- Jessica A. Thomes Pepin
-
Minneapolis, Minnesota, United States, 55455
- Recruiting
- University of Minnesota/Masonic Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 612-624-2620
-
Principal Investigator:
- Britt K. Erickson
-
Saint Louis Park, Minnesota, United States, 55416
- Recruiting
- Park Nicollet Clinic - Saint Louis Park
-
Contact:
- Site Public Contact
- Phone Number: 952-993-1517
- Email: mmcorc@healthpartners.com
-
Principal Investigator:
- Jessica A. Thomes Pepin
-
Saint Paul, Minnesota, United States, 55101
- Recruiting
- Regions Hospital
-
Contact:
- Site Public Contact
- Phone Number: 952-993-1517
- Email: mmcorc@healthpartners.com
-
Principal Investigator:
- Jessica A. Thomes Pepin
-
Saint Paul, Minnesota, United States, 55102
- Recruiting
- United Hospital
-
Contact:
- Site Public Contact
- Phone Number: 952-993-1517
- Email: mmcorc@healthpartners.com
-
Principal Investigator:
- Jessica A. Thomes Pepin
-
-
Missouri
-
Columbia, Missouri, United States, 65212
- Recruiting
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 573-882-7440
-
Principal Investigator:
- Mark I. Hunter
-
Rolla, Missouri, United States, 65401
- Recruiting
- Delbert Day Cancer Institute at PCRMC
-
Principal Investigator:
- Jay W. Carlson
-
Contact:
- Site Public Contact
- Phone Number: 573-458-7504
- Email: research@phelpshealth.org
-
Saint Louis, Missouri, United States, 63110
- Recruiting
- Washington University School of Medicine
-
Contact:
- Site Public Contact
- Phone Number: 800-600-3606
- Email: info@siteman.wustl.edu
-
Principal Investigator:
- Premal H. Thaker
-
Saint Louis, Missouri, United States, 63141
- Recruiting
- Mercy Hospital Saint Louis
-
Principal Investigator:
- Jay W. Carlson
-
Contact:
- Site Public Contact
- Phone Number: 314-251-7066
-
Springfield, Missouri, United States, 65807
- Recruiting
- CoxHealth South Hospital
-
Principal Investigator:
- Jay W. Carlson
-
Contact:
- Site Public Contact
- Phone Number: 417-269-4520
-
-
Montana
-
Anaconda, Montana, United States, 59711
- Recruiting
- Community Hospital of Anaconda
-
Principal Investigator:
- John M. Schallenkamp
-
Contact:
- Site Public Contact
- Phone Number: 406-969-6060
- Email: mccinfo@mtcancer.org
-
Billings, Montana, United States, 59101
- Recruiting
- Billings Clinic Cancer Center
-
Principal Investigator:
- John M. Schallenkamp
-
Contact:
- Site Public Contact
- Phone Number: 800-996-2663
- Email: research@billingsclinic.org
-
Bozeman, Montana, United States, 59715
- Recruiting
- Bozeman Deaconess Hospital
-
Principal Investigator:
- John M. Schallenkamp
-
Contact:
- Site Public Contact
- Phone Number: 406-969-6060
- Email: mccinfo@mtcancer.org
-
Great Falls, Montana, United States, 59405
- Recruiting
- Benefis Healthcare- Sletten Cancer Institute
-
Principal Investigator:
- John M. Schallenkamp
-
Contact:
- Site Public Contact
- Phone Number: 406-969-6060
- Email: mccinfo@mtcancer.org
-
Kalispell, Montana, United States, 59901
- Recruiting
- Kalispell Regional Medical Center
-
Principal Investigator:
- John M. Schallenkamp
-
Contact:
- Site Public Contact
- Phone Number: 406-969-6060
- Email: mccinfo@mtcancer.org
-
Missoula, Montana, United States, 59804
- Recruiting
- Community Medical Hospital
-
Principal Investigator:
- John M. Schallenkamp
-
Contact:
- Site Public Contact
- Phone Number: 406-969-6060
- Email: mccinfo@mtcancer.org
-
Missoula, Montana, United States, 59802
- Recruiting
- Saint Patrick Hospital - Community Hospital
-
Contact:
- Site Public Contact
- Phone Number: 406-327-3118
- Email: amy.hanneman@providence.org
-
Principal Investigator:
- Nitya Alluri
-
-
Nebraska
-
Omaha, Nebraska, United States, 68114
- Recruiting
- Nebraska Methodist Hospital
-
Contact:
- Site Public Contact
- Phone Number: 402-354-5144
-
Principal Investigator:
- Brent J. Tierney
-
Omaha, Nebraska, United States, 68124
- Recruiting
- Alegent Health Bergan Mercy Medical Center
-
Principal Investigator:
- Shahzad Siddique
-
Contact:
- Site Public Contact
- Phone Number: 402-717-1510
- Email: ResearchInstituteInquiries@CommonSpirit.org
-
Omaha, Nebraska, United States, 68114
- Suspended
- Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
-
-
Nevada
-
Las Vegas, Nevada, United States, 89102
- Recruiting
- OptumCare Cancer Care at Charleston
-
Contact:
- Site Public Contact
- Phone Number: 702-384-0013
- Email: research@sncrf.org
-
Principal Investigator:
- John A. Ellerton
-
Las Vegas, Nevada, United States, 89148
- Recruiting
- OptumCare Cancer Care at Fort Apache
-
Contact:
- Site Public Contact
- Phone Number: 702-384-0013
- Email: research@sncrf.org
-
Principal Investigator:
- John A. Ellerton
-
Las Vegas, Nevada, United States, 89106
- Recruiting
- Women's Cancer Center of Nevada
-
Contact:
- Site Public Contact
- Phone Number: 702-693-6870
- Email: jamador@wccenter.com
-
Principal Investigator:
- Nicola M. Spirtos
-
-
New Jersey
-
Basking Ridge, New Jersey, United States, 07920
- Recruiting
- Memorial Sloan Kettering Basking Ridge
-
Contact:
- Site Public Contact
- Phone Number: 212-639-7592
-
Principal Investigator:
- Carol Aghajanian
-
Lakewood, New Jersey, United States, 08701
- Recruiting
- Monmouth Medical Center Southern Campus
-
Contact:
- Site Public Contact
- Phone Number: 732-923-6564
- Email: mary.danish@rwjbh.org
-
Principal Investigator:
- Eugenia Girda
-
Livingston, New Jersey, United States, 07039
- Recruiting
- Saint Barnabas Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 973-322-2934
- Email: joanne.loeb@rwjbh.org
-
Principal Investigator:
- Eugenia Girda
-
Long Branch, New Jersey, United States, 07740
- Recruiting
- Monmouth Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 732-923-6564
- Email: mary.danish@rwjbh.org
-
Principal Investigator:
- Eugenia Girda
-
Middletown, New Jersey, United States, 07748
- Recruiting
- Memorial Sloan Kettering Monmouth
-
Contact:
- Site Public Contact
- Phone Number: 212-639-7592
-
Principal Investigator:
- Carol Aghajanian
-
Montvale, New Jersey, United States, 07645
- Recruiting
- Memorial Sloan Kettering Bergen
-
Contact:
- Site Public Contact
- Phone Number: 212-639-7592
-
Principal Investigator:
- Carol Aghajanian
-
Moorestown, New Jersey, United States, 08057
- Recruiting
- Virtua Samson Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 856-247-7395
-
Principal Investigator:
- Randolph B. Deger
-
Neptune, New Jersey, United States, 07753
- Recruiting
- Jersey Shore Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 732-776-4240
-
Principal Investigator:
- Karim S. ElSahwi
-
New Brunswick, New Jersey, United States, 08903
- Recruiting
- Rutgers Cancer Institute of New Jersey
-
Contact:
- Site Public Contact
- Phone Number: 732-235-7356
-
Principal Investigator:
- Eugenia Girda
-
Somerville, New Jersey, United States, 08876
- Recruiting
- Robert Wood Johnson University Hospital Somerset
-
Contact:
- Site Public Contact
- Phone Number: 908-685-2481
- Email: Siby.Varughese@rwjbh.org
-
Principal Investigator:
- Eugenia Girda
-
Voorhees, New Jersey, United States, 08043
- Recruiting
- Virtua Voorhees
-
Contact:
- Site Public Contact
- Phone Number: 856-247-7395
-
Principal Investigator:
- Randolph B. Deger
-
-
New Mexico
-
Albuquerque, New Mexico, United States, 87102
- Recruiting
- University of New Mexico Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 505-925-0348
- Email: HSC-ClinicalTrialInfo@salud.unm.edu
-
Principal Investigator:
- Colleen C. McCormick
-
Albuquerque, New Mexico, United States, 87110
- Suspended
- Presbyterian Kaseman Hospital
-
Rio Rancho, New Mexico, United States, 87124
- Suspended
- Presbyterian Rust Medical Center/Jorgensen Cancer Center
-
-
New York
-
Albany, New York, United States, 12208
- Recruiting
- Women's Cancer Care Associates LLC
-
Principal Investigator:
- Peter J. Frederick
-
Contact:
- Site Public Contact
- Phone Number: 518-458-1390
- Email: jbarlin@womenscancercareassociates.com
-
Commack, New York, United States, 11725
- Recruiting
- Memorial Sloan Kettering Commack
-
Contact:
- Site Public Contact
- Phone Number: 212-639-7592
-
Principal Investigator:
- Carol Aghajanian
-
Harrison, New York, United States, 10604
- Recruiting
- Memorial Sloan Kettering Westchester
-
Contact:
- Site Public Contact
- Phone Number: 212-639-7592
-
Principal Investigator:
- Carol Aghajanian
-
Mineola, New York, United States, 11501
- Recruiting
- NYU Winthrop Hospital
-
Contact:
- Site Public Contact
- Phone Number: 212-263-4432
- Email: cancertrials@nyulangone.org
-
Principal Investigator:
- Whitfield B. Growdon
-
New York, New York, United States, 10065
- Recruiting
- Memorial Sloan Kettering Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 212-639-7592
-
Principal Investigator:
- Carol Aghajanian
-
New York, New York, United States, 10011
- Recruiting
- Mount Sinai Chelsea
-
Principal Investigator:
- Stephanie V. Blank
-
Contact:
- Site Public Contact
- Phone Number: 212-824-7309
- Email: CCTO@mssm.edu
-
New York, New York, United States, 10016
- Recruiting
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
-
Contact:
- Site Public Contact
- Email: CancerTrials@nyulangone.org
-
Principal Investigator:
- Whitfield B. Growdon
-
New York, New York, United States, 10029
- Recruiting
- Mount Sinai Hospital
-
Principal Investigator:
- Stephanie V. Blank
-
Contact:
- Site Public Contact
- Phone Number: 212-824-7309
- Email: CCTO@mssm.edu
-
Rochester, New York, United States, 14642
- Recruiting
- University of Rochester
-
Contact:
- Site Public Contact
- Phone Number: 585-275-5830
-
Principal Investigator:
- Richard G. Moore
-
Syracuse, New York, United States, 13210
- Recruiting
- State University of New York Upstate Medical University
-
Contact:
- Site Public Contact
- Phone Number: 315-464-5476
-
Principal Investigator:
- Mary J. Cunningham
-
Uniondale, New York, United States, 11553
- Recruiting
- Memorial Sloan Kettering Nassau
-
Contact:
- Site Public Contact
- Phone Number: 212-639-7592
-
Principal Investigator:
- Carol Aghajanian
-
-
North Carolina
-
Cary, North Carolina, United States, 27518
- Recruiting
- Duke Cancer Institute Cary
-
Contact:
- Site Public Contact
- Phone Number: 919-781-7070
-
Principal Investigator:
- Angeles A. Secord
-
Chapel Hill, North Carolina, United States, 27599
- Recruiting
- UNC Lineberger Comprehensive Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 877-668-0683
- Email: cancerclinicaltrials@med.unc.edu
-
Principal Investigator:
- Linda Van Le
-
Durham, North Carolina, United States, 27710
- Recruiting
- Duke University Medical Center
-
Principal Investigator:
- Angeles A. Secord
-
Contact:
- Site Public Contact
- Phone Number: 888-275-3853
-
High Point, North Carolina, United States, 27262
- Recruiting
- Hayworth Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 336-802-2500
-
Principal Investigator:
- Janelle Darby
-
Raleigh, North Carolina, United States, 27607
- Recruiting
- Duke Women's Cancer Care Raleigh
-
Principal Investigator:
- Angeles A. Secord
-
Contact:
- Site Public Contact
- Phone Number: 919-785-4878
-
Wilmington, North Carolina, United States, 28401
- Recruiting
- Novant Health New Hanover Regional Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 910-342-3000
-
Principal Investigator:
- Lucybeth Nieves-Arriba
-
Winston-Salem, North Carolina, United States, 27157
- Recruiting
- Wake Forest University Health Sciences
-
Contact:
- Site Public Contact
- Phone Number: 336-713-6771
-
Principal Investigator:
- Janelle Darby
-
-
North Dakota
-
Fargo, North Dakota, United States, 58122
- Recruiting
- Sanford Broadway Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 701-323-5760
- Email: OncologyClinicalTrialsFargo@sanfordhealth.org
-
Principal Investigator:
- Maria C. Bell
-
Fargo, North Dakota, United States, 58122
- Recruiting
- Sanford Roger Maris Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 701-234-6161
- Email: OncologyClinicalTrialsFargo@sanfordhealth.org
-
Principal Investigator:
- Maria C. Bell
-
-
Ohio
-
Beachwood, Ohio, United States, 44122
- Recruiting
- UHHS-Chagrin Highlands Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 800-641-2422
- Email: CTUReferral@UHhospitals.org
-
Principal Investigator:
- Amy Armstrong
-
Belpre, Ohio, United States, 45714
- Recruiting
- Strecker Cancer Center-Belpre
-
Contact:
- Site Public Contact
- Phone Number: 800-523-3977
- Email: sheree@columbusccop.org
-
Principal Investigator:
- Timothy D. Moore
-
Canton, Ohio, United States, 44710
- Recruiting
- Aultman Health Foundation
-
Principal Investigator:
- Raza A. Khan
-
Contact:
- Site Public Contact
- Phone Number: 330-363-7274
- Email: ClinicalReserachDept@aultman.com
-
Centerville, Ohio, United States, 45459
- Recruiting
- Miami Valley Hospital South
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Michael S. Guy
-
Chardon, Ohio, United States, 44024
- Recruiting
- Geauga Hospital
-
Contact:
- Site Public Contact
- Phone Number: 800-641-2422
- Email: CTUReferral@UHhospitals.org
-
Principal Investigator:
- Amy Armstrong
-
Chillicothe, Ohio, United States, 45601
- Recruiting
- Adena Regional Medical Center
-
Principal Investigator:
- Timothy D. Moore
-
Contact:
- Site Public Contact
- Phone Number: 877-779-7585
- Email: sheree@columbusccop.org
-
Cincinnati, Ohio, United States, 45220
- Recruiting
- Good Samaritan Hospital - Cincinnati
-
Principal Investigator:
- Shahzad Siddique
-
Contact:
- Site Public Contact
- Phone Number: 513-853-1300
- Email: ResearchInstituteInquiries@CommonSpirit.org
-
Cleveland, Ohio, United States, 44106
- Recruiting
- Case Western Reserve University
-
Contact:
- Site Public Contact
- Phone Number: 800-641-2422
- Email: CTUReferral@UHhospitals.org
-
Principal Investigator:
- Amy Armstrong
-
Cleveland, Ohio, United States, 44109
- Recruiting
- MetroHealth Medical Center
-
Principal Investigator:
- Kimberly E. Resnick
-
Contact:
- Site Public Contact
- Phone Number: 216-778-7559
- Email: ababal@metrohealth.org
-
Columbus, Ohio, United States, 43213
- Recruiting
- Mount Carmel East Hospital
-
Principal Investigator:
- Timothy D. Moore
-
Contact:
- Site Public Contact
- Phone Number: 614-488-2118
- Email: sheree@columbusccop.org
-
Columbus, Ohio, United States, 43219
- Recruiting
- The Mark H Zangmeister Center
-
Principal Investigator:
- Timothy D. Moore
-
Contact:
- Site Public Contact
- Phone Number: 614-488-2118
- Email: sheree@columbusccop.org
-
Columbus, Ohio, United States, 43210
- Recruiting
- Ohio State University Comprehensive Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-293-5066
- Email: Jamesline@osumc.edu
-
Principal Investigator:
- Casey Cosgrove
-
Columbus, Ohio, United States, 43214
- Suspended
- Riverside Methodist Hospital
-
Dayton, Ohio, United States, 45409
- Recruiting
- Miami Valley Hospital
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Michael S. Guy
-
Grove City, Ohio, United States, 43123
- Recruiting
- Mount Carmel Grove City Hospital
-
Principal Investigator:
- Timothy D. Moore
-
Contact:
- Site Public Contact
- Phone Number: 877-779-7585
- Email: sheree@columbusccop.org
-
Lancaster, Ohio, United States, 43130
- Recruiting
- Fairfield Medical Center
-
Principal Investigator:
- Timothy D. Moore
-
Contact:
- Site Public Contact
- Phone Number: 740-687-8863
- Email: sheree@columbusccop.org
-
Lima, Ohio, United States, 45801
- Recruiting
- Saint Rita's Medical Center
-
Principal Investigator:
- Timothy D. Moore
-
Contact:
- Site Public Contact
- Phone Number: 419-226-9617
-
Marietta, Ohio, United States, 45750
- Recruiting
- Marietta Memorial Hospital
-
Contact:
- Site Public Contact
- Phone Number: 800-523-3977
- Email: sheree@columbusccop.org
-
Principal Investigator:
- Timothy D. Moore
-
Marysville, Ohio, United States, 43040
- Recruiting
- Memorial Hospital
-
Principal Investigator:
- Timothy D. Moore
-
Contact:
- Site Public Contact
- Phone Number: 614-488-2118
- Email: sheree@columbusccop.org
-
Mentor, Ohio, United States, 44060
- Recruiting
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Contact:
- Site Public Contact
- Phone Number: 800-641-2422
- Email: CTUReferral@UHhospitals.org
-
Principal Investigator:
- Amy Armstrong
-
Mount Vernon, Ohio, United States, 43050
- Recruiting
- Knox Community Hospital
-
Principal Investigator:
- Timothy D. Moore
-
Contact:
- Site Public Contact
- Phone Number: 740-393-9000
- Email: sheree@columbusccop.org
-
Newark, Ohio, United States, 43055
- Recruiting
- Licking Memorial Hospital
-
Principal Investigator:
- Timothy D. Moore
-
Contact:
- Site Public Contact
- Phone Number: 740-348-4000
- Email: sheree@columbusccop.org
-
Perrysburg, Ohio, United States, 43551
- Recruiting
- Mercy Health Perrysburg Cancer Center
-
Principal Investigator:
- Timothy D. Moore
-
Contact:
- Site Public Contact
- Phone Number: 614-488-2118
- Email: sheree@columbusccop.org
-
Portsmouth, Ohio, United States, 45662
- Recruiting
- Southern Ohio Medical Center
-
Principal Investigator:
- Timothy D. Moore
-
Contact:
- Site Public Contact
- Phone Number: 614-488-2118
- Email: sheree@columbusccop.org
-
Springfield, Ohio, United States, 45504
- Recruiting
- Springfield Regional Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Timothy D. Moore
-
Springfield, Ohio, United States, 45505
- Recruiting
- Springfield Regional Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Timothy D. Moore
-
Sylvania, Ohio, United States, 43560
- Recruiting
- ProMedica Flower Hospital
-
Contact:
- Site Public Contact
- Phone Number: 419-824-1842
- Email: PCIOncResearch@promedica.org
-
Principal Investigator:
- Kathleen G. Essel
-
Toledo, Ohio, United States, 43608
- Recruiting
- Saint Vincent Mercy Medical Center
-
Principal Investigator:
- Timothy D. Moore
-
Contact:
- Site Public Contact
- Phone Number: 614-488-2118
- Email: sheree@columbusccop.org
-
Toledo, Ohio, United States, 43623
- Recruiting
- Mercy Health - Saint Anne Hospital
-
Principal Investigator:
- Timothy D. Moore
-
Contact:
- Site Public Contact
- Phone Number: 614-488-2118
- Email: sheree@columbusccop.org
-
Westerville, Ohio, United States, 43081
- Recruiting
- Saint Ann's Hospital
-
Principal Investigator:
- Timothy D. Moore
-
Contact:
- Site Public Contact
- Phone Number: 614-234-5433
- Email: sheree@columbusccop.org
-
Westlake, Ohio, United States, 44145
- Recruiting
- UH Seidman Cancer Center at Saint John Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 800-641-2422
- Email: CTUReferral@UHhospitals.org
-
Principal Investigator:
- Amy Armstrong
-
Zanesville, Ohio, United States, 43701
- Recruiting
- Genesis Healthcare System Cancer Care Center
-
Principal Investigator:
- Timothy D. Moore
-
Contact:
- Site Public Contact
- Phone Number: 740-454-5232
- Email: sheree@columbusccop.org
-
-
Oklahoma
-
Oklahoma City, Oklahoma, United States, 73104
- Recruiting
- University of Oklahoma Health Sciences Center
-
Contact:
- Site Public Contact
- Phone Number: 405-271-8777
- Email: ou-clinical-trials@ouhsc.edu
-
Principal Investigator:
- Lauren E. Dockery
-
Tulsa, Oklahoma, United States, 74146
- Recruiting
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
Contact:
- Site Public Contact
- Phone Number: 918-505-3200
-
Principal Investigator:
- Lauren E. Dockery
-
-
Oregon
-
Newberg, Oregon, United States, 97132
- Recruiting
- Providence Newberg Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 503-215-2614
- Email: CanRsrchStudies@providence.org
-
Principal Investigator:
- Nitya Alluri
-
Ontario, Oregon, United States, 97914
- Recruiting
- Saint Alphonsus Medical Center-Ontario
-
Principal Investigator:
- John M. Schallenkamp
-
Contact:
- Site Public Contact
- Phone Number: 406-969-6060
- Email: mccinfo@mtcancer.org
-
Portland, Oregon, United States, 97239
- Recruiting
- Oregon Health and Science University
-
Contact:
- Site Public Contact
- Phone Number: 503-494-1080
- Email: trials@ohsu.edu
-
Principal Investigator:
- Jessica Jou
-
Portland, Oregon, United States, 97213
- Recruiting
- Providence Portland Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 503-215-2614
- Email: CanRsrchStudies@providence.org
-
Principal Investigator:
- Nitya Alluri
-
Portland, Oregon, United States, 97225
- Recruiting
- Providence Saint Vincent Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 503-215-2614
- Email: CanRsrchStudies@providence.org
-
Principal Investigator:
- Nitya Alluri
-
Portland, Oregon, United States, 97210
- Recruiting
- Legacy Good Samaritan Hospital and Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 800-220-4937
- Email: cancer@lhs.org
-
Principal Investigator:
- Julia Fehniger
-
Tualatin, Oregon, United States, 97062
- Recruiting
- Legacy Meridian Park Hospital
-
Contact:
- Site Public Contact
- Phone Number: 503-413-1742
-
Principal Investigator:
- Julia Fehniger
-
-
Pennsylvania
-
Bryn Mawr, Pennsylvania, United States, 19010
- Recruiting
- Bryn Mawr Hospital
-
Contact:
- Site Public Contact
- Phone Number: 484-476-2649
- Email: turzoe@mlhs.org
-
Principal Investigator:
- Albert S. DeNittis
-
Erie, Pennsylvania, United States, 16544
- Suspended
- Saint Vincent Hospital
-
Jefferson Hills, Pennsylvania, United States, 15025
- Recruiting
- Jefferson Hospital
-
Contact:
- Site Public Contact
- Phone Number: 412-359-3043
- Email: ddefazio@wpahs.org
-
Principal Investigator:
- Eirwen M. Miller
-
Media, Pennsylvania, United States, 19063
- Recruiting
- Riddle Memorial Hospital
-
Contact:
- Site Public Contact
- Phone Number: 484-476-2649
- Email: turzoe@mlhs.org
-
Principal Investigator:
- Albert S. DeNittis
-
Monroeville, Pennsylvania, United States, 15146
- Recruiting
- Forbes Hospital
-
Contact:
- Site Public Contact
- Phone Number: 412-858-7746
-
Principal Investigator:
- Eirwen M. Miller
-
Paoli, Pennsylvania, United States, 19301
- Recruiting
- Paoli Memorial Hospital
-
Contact:
- Site Public Contact
- Phone Number: 484-476-2649
- Email: turzoe@mlhs.org
-
Principal Investigator:
- Albert S. DeNittis
-
Philadelphia, Pennsylvania, United States, 19107
- Recruiting
- Thomas Jefferson University Hospital
-
Contact:
- Site Public Contact
- Phone Number: 215-600-9151
- Email: ONCTrialNow@jefferson.edu
-
Principal Investigator:
- Mitchell I. Edelson
-
Philadelphia, Pennsylvania, United States, 19107
- Recruiting
- Pennsylvania Hospital
-
Contact:
- Site Public Contact
- Phone Number: 800-789-7366
-
Principal Investigator:
- Patricia A. Locantore-Ford
-
Pittsburgh, Pennsylvania, United States, 15224
- Recruiting
- West Penn Hospital
-
Contact:
- Site Public Contact
- Phone Number: 412-578-5000
-
Principal Investigator:
- Eirwen M. Miller
-
West Chester, Pennsylvania, United States, 19380
- Recruiting
- Chester County Hospital
-
Contact:
- Site Public Contact
- Phone Number: 610-431-5297
-
Principal Investigator:
- Maureen R. Hewitt
-
Wexford, Pennsylvania, United States, 15090
- Recruiting
- Wexford Health and Wellness Pavilion
-
Contact:
- Site Public Contact
- Email: Dawnmarie.DeFazio@ahn.org
-
Principal Investigator:
- Eirwen M. Miller
-
Willow Grove, Pennsylvania, United States, 19090
- Recruiting
- Asplundh Cancer Pavilion
-
Contact:
- Site Public Contact
- Phone Number: 215-600-9151
- Email: ONCTrialNow@jefferson.edu
-
Principal Investigator:
- Mitchell I. Edelson
-
Wynnewood, Pennsylvania, United States, 19096
- Recruiting
- Lankenau Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 484-476-2649
- Email: turzoe@mlhs.org
-
Principal Investigator:
- Albert S. DeNittis
-
-
Rhode Island
-
Providence, Rhode Island, United States, 02905
- Recruiting
- Women and Infants Hospital
-
Contact:
- Site Public Contact
- Phone Number: 401-274-1122
-
Principal Investigator:
- Cara A. Mathews
-
Westerly, Rhode Island, United States, 02891
- Recruiting
- Smilow Cancer Hospital Care Center - Westerly
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Alessandro D. Santin
-
-
South Carolina
-
Bluffton, South Carolina, United States, 29910
- Recruiting
- Saint Joseph's/Candler - Bluffton Campus
-
Contact:
- Site Public Contact
- Phone Number: 912-819-5704
- Email: underberga@sjchs.org
-
Principal Investigator:
- Sarah E. Gill
-
Charleston, South Carolina, United States, 29425
- Suspended
- Medical University of South Carolina
-
-
South Dakota
-
Aberdeen, South Dakota, United States, 57401
- Recruiting
- Avera Cancer Institute-Aberdeen
-
Principal Investigator:
- David C. Starks
-
Contact:
- Site Public Contact
- Phone Number: 605-622-8700
- Email: oncregulatory@avera.org
-
Sioux Falls, South Dakota, United States, 57104
- Recruiting
- Sanford Cancer Center Oncology Clinic
-
Contact:
- Site Public Contact
- Phone Number: 605-312-3320
- Email: OncologyClinicTrialsSF@sanfordhealth.org
-
Principal Investigator:
- Maria C. Bell
-
Sioux Falls, South Dakota, United States, 57117-5134
- Recruiting
- Sanford USD Medical Center - Sioux Falls
-
Contact:
- Site Public Contact
- Phone Number: 605-312-3320
- Email: OncologyClinicalTrialsSF@SanfordHealth.org
-
Principal Investigator:
- Maria C. Bell
-
Sioux Falls, South Dakota, United States, 57105
- Recruiting
- Avera Cancer Institute
-
Contact:
- Site Public Contact
- Phone Number: 605-322-3095
- Email: OncRegulatory@avera.org
-
Principal Investigator:
- David C. Starks
-
-
Tennessee
-
Germantown, Tennessee, United States, 38138
- Recruiting
- The West Clinic - Wolf River
-
Contact:
- Site Public Contact
- Phone Number: 901-683-0055
- Email: afletcher@westclinic.com
-
Principal Investigator:
- Todd D. Tillmanns
-
-
Texas
-
Austin, Texas, United States, 78701
- Recruiting
- Dell Seton Medical Center at The University of Texas
-
Contact:
- Site Public Contact
- Phone Number: 512-324-7991
-
Principal Investigator:
- Marian Y. Williams-Brown
-
Dallas, Texas, United States, 75390
- Recruiting
- UT Southwestern/Simmons Cancer Center-Dallas
-
Principal Investigator:
- Jayanthi S. Lea
-
Contact:
- Site Public Contact
- Phone Number: 214-648-7097
- Email: canceranswerline@UTSouthwestern.edu
-
Dallas, Texas, United States, 75235
- Recruiting
- Parkland Memorial Hospital
-
Principal Investigator:
- Jayanthi S. Lea
-
Contact:
- Site Public Contact
- Phone Number: 214-590-5582
- Email: canceranswerline@UTSouthwestern.edu
-
Houston, Texas, United States, 77030
- Recruiting
- Houston Methodist Hospital
-
Contact:
- Site Public Contact
- Phone Number: 713-790-2700
-
Principal Investigator:
- Aparna A. Kamat
-
Houston, Texas, United States, 77070
- Recruiting
- Methodist Willowbrook Hospital
-
Contact:
- Site Public Contact
- Phone Number: 412-339-5294
- Email: Roster@nrgoncology.org
-
Principal Investigator:
- Aparna A. Kamat
-
Houston, Texas, United States, 77094
- Recruiting
- Houston Methodist West Hospital
-
Contact:
- Site Public Contact
- Phone Number: 832-522-2873
-
Principal Investigator:
- Aparna A. Kamat
-
Nassau Bay, Texas, United States, 77058
- Recruiting
- Houston Methodist Saint John Hospital
-
Contact:
- Site Public Contact
- Phone Number: 412-339-5294
- Email: Roster@nrgoncology.org
-
Principal Investigator:
- Aparna A. Kamat
-
Richardson, Texas, United States, 75080
- Recruiting
- UT Southwestern Clinical Center at Richardson/Plano
-
Principal Investigator:
- Jayanthi S. Lea
-
Contact:
- Site Public Contact
- Phone Number: 972-669-7044
- Email: Suzanne.cole@utsouthwestern.edu
-
Sugar Land, Texas, United States, 77479
- Recruiting
- Houston Methodist Sugar Land Hospital
-
Contact:
- Site Public Contact
- Phone Number: 281-242-2873
-
Principal Investigator:
- Aparna A. Kamat
-
The Woodlands, Texas, United States, 77385
- Recruiting
- Houston Methodist The Woodlands Hospital
-
Contact:
- Site Public Contact
- Phone Number: 713-790-2700
- Email: hmthewoodlands@houstonmethodist.org
-
Principal Investigator:
- Aparna A. Kamat
-
-
Utah
-
Salt Lake City, Utah, United States, 84112
- Recruiting
- Huntsman Cancer Institute/University of Utah
-
Principal Investigator:
- Kristen Kelley
-
Contact:
- Site Public Contact
- Phone Number: 888-424-2100
- Email: cancerinfo@hci.utah.edu
-
South Jordan, Utah, United States, 84009
- Recruiting
- South Jordan Health Center
-
Principal Investigator:
- Kristen Kelley
-
Contact:
- Site Public Contact
- Phone Number: 888-424-2100
- Email: cancerinfo@hci.utah.edu
-
-
Virginia
-
Richmond, Virginia, United States, 23298
- Recruiting
- Virginia Commonwealth University/Massey Cancer Center
-
Contact:
- Site Public Contact
- Email: CTOclinops@vcu.edu
-
Principal Investigator:
- Leslie M. Randall
-
Richmond, Virginia, United States, 23235
- Recruiting
- VCU Massey Cancer Center at Stony Point
-
Contact:
- Site Public Contact
- Email: CTOclinops@vcu.edu
-
Principal Investigator:
- Leslie M. Randall
-
Roanoke, Virginia, United States, 24016
- Recruiting
- Carilion Clinic Gynecological Oncology
-
Contact:
- Site Public Contact
- Phone Number: 540-985-8510
-
Principal Investigator:
- Leslie M. Randall
-
-
Washington
-
Edmonds, Washington, United States, 98026
- Recruiting
- Swedish Cancer Institute-Edmonds
-
Contact:
- Site Public Contact
- Phone Number: 206-215-3086
- Email: PCRC-NCORP@Swedish.org
-
Principal Investigator:
- Nitya Alluri
-
Seattle, Washington, United States, 98122
- Recruiting
- Swedish Medical Center-First Hill
-
Contact:
- Site Public Contact
- Phone Number: 206-215-3086
- Email: PCRC-NCORP@Swedish.org
-
Principal Investigator:
- Nitya Alluri
-
Vancouver, Washington, United States, 98686
- Recruiting
- Legacy Salmon Creek Hospital
-
Contact:
- Site Public Contact
- Phone Number: 503-413-2150
-
Principal Investigator:
- Julia Fehniger
-
-
West Virginia
-
Charleston, West Virginia, United States, 25304
- Recruiting
- West Virginia University Charleston Division
-
Contact:
- Site Public Contact
- Phone Number: 304-388-9944
-
Principal Investigator:
- Stephen H. Bush
-
Morgantown, West Virginia, United States, 26506
- Recruiting
- West Virginia University Healthcare
-
Contact:
- Site Public Contact
- Phone Number: 304-293-7374
- Email: cancertrialsinfo@hsc.wvu.edu
-
Principal Investigator:
- Krista S. Pfaendler
-
-
Wisconsin
-
Green Bay, Wisconsin, United States, 54301
- Recruiting
- Saint Vincent Hospital Cancer Center Green Bay
-
Contact:
- Site Public Contact
- Phone Number: 920-433-8889
- Email: ewd_research_admin@hshs.org
-
Principal Investigator:
- Matthew L. Ryan
-
Green Bay, Wisconsin, United States, 54303
- Recruiting
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Contact:
- Site Public Contact
- Phone Number: 920-433-8889
- Email: ewd_research_admin@hshs.org
-
Principal Investigator:
- Matthew L. Ryan
-
La Crosse, Wisconsin, United States, 54601
- Recruiting
- Gundersen Lutheran Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 608-775-2385
- Email: cancerctr@gundersenhealth.org
-
Principal Investigator:
- Gil Harmon
-
Madison, Wisconsin, United States, 53792
- Recruiting
- University of Wisconsin Carbone Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-622-8922
-
Principal Investigator:
- Ellen M. Hartenbach
-
Milwaukee, Wisconsin, United States, 53226
- Recruiting
- Medical College of Wisconsin
-
Contact:
- Site Public Contact
- Phone Number: 414-805-3666
-
Principal Investigator:
- William H. Bradley
-
Mukwonago, Wisconsin, United States, 53149
- Recruiting
- ProHealth D N Greenwald Center
-
Contact:
- Site Public Contact
- Email: research.institute@phci.org
-
Principal Investigator:
- Timothy R. Wassenaar
-
New Richmond, Wisconsin, United States, 54017
- Recruiting
- Cancer Center of Western Wisconsin
-
Contact:
- Site Public Contact
- Phone Number: 952-993-1517
- Email: mmcorc@healthpartners.com
-
Principal Investigator:
- Jessica A. Thomes Pepin
-
Oconomowoc, Wisconsin, United States, 53066
- Recruiting
- ProHealth Oconomowoc Memorial Hospital
-
Principal Investigator:
- Timothy R. Wassenaar
-
Contact:
- Site Public Contact
- Phone Number: 262-928-7878
-
Oconto Falls, Wisconsin, United States, 54154
- Recruiting
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Contact:
- Site Public Contact
- Phone Number: 920-433-8889
- Email: ewd_research_admin@hshs.org
-
Principal Investigator:
- Matthew L. Ryan
-
Sheboygan, Wisconsin, United States, 53081
- Recruiting
- Saint Vincent Hospital Cancer Center at Sheboygan
-
Contact:
- Site Public Contact
- Phone Number: 920-433-8889
- Email: ewd_research_admin@hshs.org
-
Principal Investigator:
- Matthew L. Ryan
-
Sturgeon Bay, Wisconsin, United States, 54235-1495
- Recruiting
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Contact:
- Site Public Contact
- Phone Number: 920-433-8889
- Email: ewd_research_admin@hshs.org
-
Principal Investigator:
- Matthew L. Ryan
-
Waukesha, Wisconsin, United States, 53188
- Recruiting
- UW Cancer Center at ProHealth Care
-
Principal Investigator:
- Timothy R. Wassenaar
-
Contact:
- Site Public Contact
- Phone Number: 262-928-5539
- Email: Chanda.miller@phci.org
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Federation of Gynecology and Obstetrics (FIGO) 2009 stage IA-IVB, non-recurrent, chemotherapy (chemo)-naive, HER2-positive endometrial serous carcinoma or endometrial carcinosarcoma
- Histologic confirmation of the original primary tumor is required. Submission of surgical pathology report (or endometrial biopsy pathology report in patients who never undergo hysterectomy) is required
- Patients must be within 8 weeks of primary surgery (or endometrial biopsy in patients who never undergo hysterectomy) at the time of study registration
- Patients may have measurable disease, non-measurable disease, or no measurable disease. In patients with measurable disease, lesions will be defined and monitored by RECIST v 1.1. Measurable disease is defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded). Each lesion must be >= 10 mm when measured by computed tomography (CT) or magnetic resonance imaging (MRI). Lymph nodes must be >= 15 mm in short axis when measured by CT or MRI
- For patients with uterine-confined (stage I) disease, the tumor must be invasive into the myometrium. Any amount of myoinvasion is acceptable for eligibility. Patients with non-invasive disease, endometrial intraepithelial carcinoma alone, or disease confined to a polyp will be excluded
Additionally, patients must have the following histologic types to be eligible:
- Serous adenocarcinoma (may include =< 10% non-serous histology)
- Carcinosarcoma with serous epithelial component (only the serous component needs to be HER2 positive; may include =< 10% non-serous histology)
- In cases where determination of serous is equivocal or challenging, aberrant p53 immunohistochemistry (IHC) (defined as overexpression of p53 compared to internal controls) will be sufficient for inclusion
All patients must have tumors that are HER2 positive as defined by American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) 2018 Breast Cancer guidelines (https://documents.cap.org/documents/algorithim-evaluation-her2.pdf. In general HER2 positivity is defined as any of the following:
- 3+ immunohistochemistry (IHC),
- 2+ IHC with positive in situ hybridization (ISH)
- Average HER2 copy number >= 6.0 signals/cell
- Average HER2 copy number >= 4.0 and < 6.0 signals/cell, with concurrent IHC 3+
- HER2/CEP17 ratio >= 4.0 signals/cell
- HER2/CEP 17 ratio >= 2.0 and < 4.0, with concurrent IHC 3+ IHC and ISH testing will be done locally, at each participating institution and interpreted by local pathologists. Alternatively, patients could be eligible if next generation sequencing (NGS) demonstrates HER2 (ERBB2) amplification. NGS testing can be performed through any designated labs as per the National Cancer Institute (NCI) MATCH/NCI Combo-MATCH trial (https://ecog-acrin.org/nci-match-eay131-designated-labs).
Pathology report showing results of institutional HER2 testing (or NGS testing results) must be submitted.
Sites must submit all results available (IHC, ISH, and NGS)
- Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2
- Age >= 18
- Platelets >= 100,000/mcl (within 14 days prior to registration)
- Absolute neutrophil count (ANC) >= 1,500/mcl (within 14 days prior to registration)
- Creatinine =< 1.5 x institutional/laboratory upper limit of normal (ULN) or estimated Glomerular filtration rate (eGFR) >= 50 mL/min using either the Cockcroft-Gault equation, the Modification of Diet in Renal Disease Study, or as reported in the comprehensive metabolic panel/basic metabolic panel (eGFR). (within 14 days prior to registration)
- Total serum bilirubin level =< 1.5 x ULN (patients with known Gilbert's disease who have bilirubin level =< 3 x ULN may be enrolled) (within 14 days prior to registration)
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN (within 14 days prior to registration)
- Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months of registration are eligible for this trial
Although the uterus will have been removed in the vast majority of patients, for patients of child-bearing potential: negative urine or serum pregnancy test. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test is required. Patients will be considered of non-reproductive potential if they are either:
- Postmenopausal (defined as at least 12 months with no menses without an alternative medical cause; in women < 45 years of age, a high follicle stimulating hormone [FSH] level in the postmenopausal range may be used to confirm a postmenopausal state in women not using hormonal contraception or hormonal replacement therapy. In the absence of 12 months of amenorrhea, a single FSH measurement is insufficient); OR
- Have had a hysterectomy and/or bilateral oophorectomy, bilateral salpingectomy or bilateral tubal ligation/occlusion at least 6 weeks prior to registration
- Have a congenital or acquired condition that prevents childbearing
- Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial. NOTE: Patients with prior anthracycline exposure are NOT eligible
- Patients with evidence of chronic hepatitis B virus (HBV) infection must have an undetectable HBV viral load on suppressive therapy, if indicated
- Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
- Patients with treated brain metastases are eligible if follow-up brain imaging after central nervous system (CNS)-directed therapy shows no evidence of progression
- The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information
Exclusion Criteria:
Prior Therapy:
- Patients must NOT have received prior chemotherapy, biologic therapy, or targeted therapy for treatment of endometrial carcinoma
Patients must NOT have received prior radiation therapy for treatment of endometrial carcinoma. Prior radiation includes external beam pelvic radiation therapy, external beam extended field pelvic/para-aortic radiation therapy, and/or intravaginal brachytherapy
- NOTE: Vaginal brachytherapy for treatment of endometrial cancer is permitted during study treatment. Planned use of vaginal brachytherapy must be declared at time of registration
- Patients may have received prior hormonal therapy for treatment of endometrial carcinoma. All hormonal therapy must be discontinued at least one week prior to registration
- Patients may not have a planned interval cytoreduction or hysterectomy, prior to documentation of progression, after study registration
- Patients may not have planned external beam radiotherapy, prior to documentation of progression, after study registration
Significant cardiovascular disease including:
- Uncontrolled hypertension, defined as systolic > 150 mm Hg or diastolic > 90 mm Hg despite antihypertensive medications
- Myocardial infarction or unstable angina within 6 months prior to registration
- New York Heart Association functional classification II, III or IV
- Serious cardiac arrhythmia requiring medication. This does not include asymptomatic, atrial fibrillation with controlled ventricular rate
- Significant lung disease: dyspnea at rest grade 2 or greater (resulting from extensive tumor involvement or other causes), pneumonitis grade 2 or greater, interstitial lung disease grade 2 or greater, idiopathic pulmonary fibrosis, cystic fibrosis, Aspergillosis, active tuberculosis, or history of opportunistic infections (pneumocystis pneumonia or cytomegalovirus pneumonia)
- Patients with uncontrolled intercurrent illness including, but not limited to: ongoing or active infection (except for uncomplicated urinary tract infection), uncontrolled interstitial lung disease, symptomatic congestive heart failure, or psychiatric illness/social situations that would limit compliance with study requirements
- Treatment with strong CYP2C8 or CYP3A4 inhibitors or inducers within 14 days or 5 drug-elimination half-lives, whichever is longer, prior to registration
- Women who are unwilling to discontinue nursing
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Arm I (paclitaxel, carboplatin)
Patients receive paclitaxel IV over 3 hours and carboplatin IV over 30-60 minutes on day 1 of each cycle. Treatment repeats every 3 weeks for 6 cycles in the absence of disease progression or unacceptable toxicity. Patients with SD or PR who still have measurable disease after completion of cycle 6 may receive 4 additional cycles of this treatment at the discretion of the treating physician. Patients undergo ECHO or MUGA scan at end of treatment and every 6 months for 2 years. |
Given IV
Other Names:
Ancillary studies
Other Names:
Given IV
Other Names:
Undergo ECHO
Other Names:
Undergo MUGA
Other Names:
|
Experimental: Arm II (paclitaxel, carboplatin, Herceptin Hylecta)
Patients receive paclitaxel IV over 3 hours, carboplatin IV over 30-60 minutes, and trastuzumab/hyaluronidase-oysk SC over 2-5 minutes on day 1 of each cycle. Treatment repeats every 3 weeks for 6 cycles in the absence of disease progression or unacceptable toxicity. Patients with SD or PR who still have measurable disease after completion of cycle 6 may receive 4 additional cycles of this treatment at the discretion of the treating physician. MAINTENANCE: Patients receive trastuzumab/hyaluronidase-oysk SC over 2-5 minutes on day 1 of each cycle. Cycles repeat every 3 weeks for up to 1 year in the absence of disease progression or unacceptable toxicity. Patients with SD or PR may continue maintenance therapy for up to 3 years from the start of treatment. Patients undergo ECHO or MUGA scan at end of treatment and every 6 months for 2 years. |
Given IV
Other Names:
Ancillary studies
Other Names:
Given IV
Other Names:
Undergo ECHO
Other Names:
Undergo MUGA
Other Names:
Given SC
Other Names:
|
Experimental: Arm III (paclitaxel, carboplatin, Phesgo)
Patients receive paclitaxel IV over 3 hours, carboplatin IV over 30-60 minutes, and pertuzumab/trastuzumab/hyaluronidase-zzxf SC over 5-8 minutes on day 1 of each cycle. Treatment repeats every 3 weeks for 6 cycles in the absence of disease progression or unacceptable toxicity. Patients with SD or PR who still have measurable disease after completion of cycle 6 may receive 4 additional cycles of this treatment at the discretion of the treating physician. MAINTENANCE: Patients receive pertuzumab/trastuzumab/ hyaluronidase-zzxf SC over 5 minutes on day 1. Cycles repeat every 3 weeks for up to 1 year in absence of disease progression or unacceptable toxicity. Patients with SD or PR may continue maintenance for up to 3 years from the start of treatment. Patients undergo ECHO or MUGA scan at end of treatment and every 6 months for 2 years. |
Given IV
Other Names:
Ancillary studies
Other Names:
Given IV
Other Names:
Undergo ECHO
Other Names:
Undergo MUGA
Other Names:
Given SC
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Progression free survival (Phase II)
Time Frame: From study entry to time of progression or death, whichever occurs first, or date of last contact if neither progression nor death has occurred, assessed up to 5 years from randomization
|
At the end of Phase 2 analysis, if both experimental arms demonstrate superiority to the reference, the experimental arms will be compared to each other.
|
From study entry to time of progression or death, whichever occurs first, or date of last contact if neither progression nor death has occurred, assessed up to 5 years from randomization
|
Incidence of dose limiting toxicities (Phase II)
Time Frame: Up to end of cycle 3 (week 12)
|
A dose limiting toxicity is any treatment-related adverse event requiring permanent discontinuation of the experimental therapy prior to the completion of treatment cycle 3.
|
Up to end of cycle 3 (week 12)
|
Overall survival (Phase III)
Time Frame: From study entry to time of death or the date of last contact, assessed up to 5 years from randomization
|
If both experimental arms demonstrate superiority to the reference arm, the experimental arms will be compared to each other.
|
From study entry to time of death or the date of last contact, assessed up to 5 years from randomization
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Objective response rate (ORR)
Time Frame: Within 12 months of initiating maintenance therapy
|
Defined as the binomial proportion of evaluable patients with a best overall response of complete response (CR) or partial response (PR) (by Response Evaluation Criteria in Solid Tumors [RECIST] 1.1) within 12 months of initiating maintenance therapy.
Responses reported by the treating physician will be used for these analyses.
The ORR estimates by treatment arm will be supported by their 2-sided, 95% Wilson-Score confidence intervals (Wilson, 1927; Agresti, 1998).
The relative odds of response in each experimental group (vs the reference group) will be estimated using a multivariable logistic regression model specified with main effects for the treatment groups and covariate adjustments for the stratification factors reported at baseline.
|
Within 12 months of initiating maintenance therapy
|
Duration of objective response
Time Frame: From documentation of either PR or CR until disease progression or death, whichever is observed first, assessed up to 5 years from randomization
|
Treatment group differences in response duration will be graphed using Kaplan-Meier methods and compared using logrank tests, stratified by the minimization factors defined at randomization.
The relative hazards of progression or death in each experimental group (vs the reference group) will be estimated using a multivariable proportional hazards regression model specified with main effects for the treatment indicators and covariate adjustments for the stratification factors reported at baseline.
|
From documentation of either PR or CR until disease progression or death, whichever is observed first, assessed up to 5 years from randomization
|
Incidence of adverse events (AEs)
Time Frame: Up to 5 years from randomization
|
The nature, frequency, and degree of toxicity will be tabulated at the System Organ Class and AE-specific term levels using Common Terminology Criteria (CTCAE) version 5.0.
Each patient will be represented according to the maximum grade observed for each term.
Tabulations will show the number and percentage of patients by maximum grade, within the treatment group received, regardless of the randomized treatment assignment.
|
Up to 5 years from randomization
|
HER2 expression
Time Frame: Up to 5 years from randomization
|
Correlation of HER2 immunohistochemistry (IHC) expression and in situ hybridization (ISH) amplification with clinical outcome and response to HER2 targeted therapies will be explored.
|
Up to 5 years from randomization
|
Quality of life
Time Frame: Up to 5 years from randomization
|
Measured by Functional Assessment of Cancer Therapy - Endometrial Trial Outcome Index (FACT-En-TOI).
|
Up to 5 years from randomization
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Britt K Erickson, NRG Oncology
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Neoplasms, Connective and Soft Tissue
- Neoplasms by Histologic Type
- Neoplasms
- Adenocarcinoma
- Carcinoma
- Neoplasms, Glandular and Epithelial
- Neoplasms, Complex and Mixed
- Sarcoma
- Cystadenocarcinoma
- Neoplasms, Cystic, Mucinous, and Serous
- Carcinosarcoma
- Mixed Tumor, Mullerian
- Cystadenocarcinoma, Serous
- Molecular Mechanisms of Pharmacological Action
- Antineoplastic Agents
- Tubulin Modulators
- Antimitotic Agents
- Mitosis Modulators
- Antineoplastic Agents, Phytogenic
- Antineoplastic Agents, Immunological
- Carboplatin
- Paclitaxel
- Trastuzumab
- Albumin-Bound Paclitaxel
- Pertuzumab
Other Study ID Numbers
- NCI-2022-01540 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- U10CA180868 (U.S. NIH Grant/Contract)
- NRG-GY026 (Other Identifier: CTEP)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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National Cancer Institute (NCI)CompletedRecurrent Uterine Corpus Carcinoma | Endometrial Clear Cell Adenocarcinoma | Endometrial Serous Adenocarcinoma | Endometrial Adenocarcinoma | Endometrial Adenosquamous CarcinomaUnited States
Clinical Trials on Carboplatin
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Eisai Inc.CompletedCancerUnited States, Austria, India
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Samyang Biopharmaceuticals CorporationCompleted
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NHS Greater Glasgow and ClydeCompletedOvarian Cancer | Fallopian Tube Cancer | Primary Peritoneal Cavity CancerUnited Kingdom, Australia, New Zealand
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Duke UniversityCompletedBrain and Central Nervous System TumorsUnited States, Canada
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National Cancer Institute (NCI)CompletedBreast Cancer | Ovarian CancerUnited States
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H. Lee Moffitt Cancer Center and Research InstituteNational Cancer Institute (NCI)CompletedUnspecified Adult Solid Tumor, Protocol SpecificUnited States
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Eli Lilly and CompanyCompletedLung NeoplasmsUnited States
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National Cancer Institute (NCI)Children's Oncology GroupCompletedBrain and Central Nervous System TumorsUnited States, Canada, Puerto Rico, Australia, Netherlands, New Zealand, Switzerland
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All India Institute of Medical Sciences, New DelhiCouncil of Scientific and Industrial Research, IndiaUnknownIntraocular RetinoblastomaIndia
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MEI Pharma, Inc.CompletedPeritoneal Neoplasms | Ovarian Cancer | Fallopian Tube CancerUnited States, Spain, Belgium, United Kingdom, Australia, Italy, Poland