Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer (ASCENT-04)
September 16, 2025 updated by: Gilead Sciences
A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer, Whose Tumors Express PD-L1
The primary objective of this study is to compare the progression-free survival (PFS) between sacituzumab govitecan-hziy (SG) and pembrolizumab versus treatment of physician's choice (TPC) and pembrolizumab in participants with previously untreated, locally advanced inoperable or metastatic triple-negative breast cancer, whose tumors express programmed cell death ligand 1 (PD-L1).
Study Overview
Status
Active, not recruiting
Conditions
Study Type
Interventional
Enrollment (Actual)
443
Phase
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Buenos Aires, Argentina, 1426
- Hospital Británico de Buenos Aires
-
CABA, Argentina, 1417
- Instituto de Oncología Ángel H. Roffo
-
Capital, Argentina, F5300COE
- Fundacion CORI para la Investigacioy y Prevención del Cancer
-
Rosario, Argentina, 2000
- Instituto de Oncología de Rosario
-
San Miguel de Tucumán, Argentina, 4000
- CAIPO Centro Para La Atención Integral Del Pacient
-
Viedma, Argentina, 8500
- Clínica Viedma
-
-
-
-
New South Wales
-
Albury, New South Wales, Australia, 2640
- Border Medical Oncology
-
Kogarah, New South Wales, Australia, 2217
- Saint George Hospital - Australia
-
North Sydney, New South Wales, Australia, 2060
- Mater Hospital - North Sydney
-
St Leonards, New South Wales, Australia, 2065
- GenesisCare - North Shore
-
-
Queensland
-
South Brisbane, Queensland, Australia, 4101
- Mater Misericordiae Limited and Mater Research Limited
-
Woolloongabba, Queensland, Australia, 4102
- Princess Alexandra Hospital
-
-
South Australia
-
Adelaide, South Australia, Australia, 5000
- Cancer Research Sa (Crsa)
-
-
Tasmania
-
Hobart, Tasmania, Australia, 7000
- Icon Cancer Centre Hobart
-
-
Victoria
-
Clayton, Victoria, Australia, 3168
- Monash Medical Centre
-
Melbourne, Victoria, Australia, 3084
- Austin Hospital
-
Parkville, Victoria, Australia, 3050
- Peter Maccallum Cancer Centre
-
-
Western Australia
-
Nedlands, Western Australia, Australia, 6009
- Breast Cancer Research Center - Western Australia
-
-
-
-
-
Innsbruck, Austria, 06020
- Medizinische Universität Innsbruck
-
Linz, Austria, 4010
- Ordensklinikum Linz GmbH Barmherzige Schwestern
-
Salzburg, Austria, A-5020
- Landeskrankenhaus Salzburg
-
Sankt Pölten, Austria, 3100
- Universitätsklinikum Sankt Pölten
-
Vienna, Austria, 1090
- Medizinische Universität Wien
-
-
-
-
-
Anderlecht, Belgium, 1070
- Institut Jules Bordet
-
Brasschaat, Belgium, 2930
- Algemeen Ziekenhuis klina
-
Brussels, Belgium, 1200
- Cliniques universitaires Saint-Luc
-
Brussels, Belgium
- Universitair Ziekenhuis Brussel
-
Charleroi, Belgium, 6000
- Grand Hopital de Charleroi - Notre Dame
-
Ghent, Belgium, 9000
- Universitair Ziekenhuis Gent
-
Leuven, Belgium, 3000
- UZ Leuven
-
Namur, Belgium, 5000
- Centre Hospitalier Universitaire Université Cathol
-
-
-
-
-
Goiânia, Brazil, 74605-070
- Hospital Araújo Jorge - Associação de Combate ao Câncer em Goiás - ACCG
-
Ijuí, Brazil, 98700-000
- Centro de Pesquisa Clinica em Oncologia - Oncosite
-
Itajaí, Brazil, 88301-220
- Hospital de Clinicas de Porto Alegre - HCPA
-
Jaú, Brazil, 17210080
- Centro de Pesquisas Clinicas da Fundacao Doutor Amaral Carvalho - Hospital Amarval Carvalho
-
Porto Alegre, Brazil, 90035-903
- Hospital de Clínicas de Porto Alegre
-
Porto Alegre, Brazil, 90610001
- Hospital Sao Lucas Da Pucrs
-
Porto Alegre, Brazil, 90035-00
- Associacao Hosptialar Moinos de Vento - Hospital Moinhos de Vento
-
Rio de Janeiro, Brazil
- Instituto Nacional de Câncer - Brazil
-
Salvador, Brazil, 40170170
- Núcleo de Oncologia da Bahia
-
Santo André, Brazil, 09060-650
- CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - Centro Universitário FMABC
-
São Paulo, Brazil, 01323-001
- Real e Benemerita Associacao Portuguesa de Beneficencia - Hospital Beneficencia Portuguesa (BP) - Unidade Paulista
-
São Paulo, Brazil, 1317000
- Clinica de Pesquisas e Centro de Estudos em Oncolo
-
São Paulo, Brazil, 14784400
- Fundação Pio XII - Hospital de Câncer de Barretos
-
São Paulo, Brazil, 4014002
- Núcleo de Pesquisa Clínica da Rede São Camilo
-
-
-
-
-
Calgary, Canada, T2N 5G2
- Tom Baker Cancer Centre
-
Edmonton, Canada, T6G 1Z2
- Cross Cancer Institute
-
Halifax, Canada, B3H 1V7
- QEII Health Sciences Centre
-
Kitchener, Canada, N2G 1G3
- Grand River Regional Cancer Centre at Grand River Hospital
-
London, Canada, N6A 5W9
- London Health Sciences Centre
-
Montreal, Canada, H3T 1E2
- Jewish General Hospital
-
Montreal, Canada, H4A 3J1
- McGill University Health Centre
-
Ontario, Canada, M5G 2M9
- Princess Margaret Cancer Centre - University Health Network
-
Ottawa, Canada, K1H 8L6
- Ottawa Hospital - General Campus
-
Toronto, Canada, M5G 1X5
- Mount Sinai Hospital
-
Toronto, Canada, M4N 3M5
- Sunnybrook Research Institute
-
Vancouver, Canada, V5Z 4E6
- British Columbia Cancer - Vancouver
-
-
-
-
-
Providencia, Chile, 7510035
- Oncovida - Santiago
-
Santiago, Chile
- Clinica IRAM
-
Santiago, Chile, 7630000
- Clinica Alemana
-
Santiago Region, Chile, 8330032
- Centro de Cancer Pontificia Universidad Catolica
-
Temuco, Chile
- James Lind Centro de Investigacion del Cancer
-
-
-
-
-
Brno, Czechia, 65653
- Masarykuv Onkologicky Ustav, Klinika Komplexni Onkologicke Pece
-
Hradec Králové, Czechia, 500 05
- Fakultni nemocnice Hradec Kralove
-
Hradec Králové, Czechia, 50005
- Fakultni Thomayerova nemocnice
-
Olomouc, Czechia, 77520
- Fakultni nemocnice Olomouc, Onkologicka klinika
-
Prague, Czechia, 12808
- Vseobecna Fakultni Nemocnice v Praze, Onkologicka klinika
-
Prague, Czechia, 100 34
- Fakultní Nemocnice Královské Vinohrady, Radioterapeuticka a onkologicka klinika
-
-
-
-
-
Avignon, France, 84918
- Sainte Catherine Institut du Cancer Avignon Provence
-
Besançon, France, 25030
- Centre Hospitalier Régional et Universitaire de Be
-
Bordeaux, France, 33000
- Polyclinique Bordeaux Nord Aquitaine
-
Brest, France, 29200
- Hôpital Morvan, Institut de cancérologie
-
Caen, France, 14000
- Centre de Lutte contre le Cancer - François Bacles
-
Clermont-Ferrand, France, 63011
- Centre Jean Perrin
-
Lyon, France, 69373
- Centre Leon Berard
-
Marseille, France, 13273
- Institut Paoli-Calmettes
-
Montpellier, France, 34298
- Institut régional du Cancer de Montpellier
-
Montpellier, France, 34070
- Centre de Cancerologie du Grand Montpellier
-
Nantes, France, 44202
- Hôpital Privé du Confluent
-
Pierre-Bénite, France, 69495
- Hospices Civils de Lyon, Hôpital Lyon Sud
-
Plérin, France, 22190
- Centre Armoricain de Radiothérapie, dImagerie Méd
-
Rennes, France, 35042
- Centre Eugène Marquis
-
Toulouse, France
- Institut Claudius Regaud - IUCT-O
-
Villejuif, France, 94800
- Institut Gustave Roussy
-
-
-
-
-
Berlin, Germany, 13125
- HELIOS Klinikum Berlin-Buch
-
Bonn, Germany, 53111
- : Gynakologisches Zentrum Bonn, Schwerpunkt Gyn. Onkologie,
-
Bottrop, Germany, 46236
- Marienhospital Bottrop
-
Cologne, Germany, 50937
- Klinik Frauenheilkunde, Uniklinik ClO, Studienzentrale
-
Erlangen, Germany, 91054
- Universitätsklinikum Erlangen, Frauen klinik
-
Essen, Germany, 45136
- Kliniken Essen-Mitte - Evangelische Huyssens-Stift
-
Freiburg im Breisgau, Germany, 79110
- Praxis für interdisziplinäre Onkologie & Hämatolog
-
Hamburg, Germany, 20249
- Facharztzentrum Eppendorf
-
Hamburg, Germany, 20246
- : Universitätsklinikum Hamburg-Eppendorf
-
Heidelberg, Germany, 69120
- Nationales Centrum für Tumorerkrankungen
-
Lübeck, Germany, 23538
- Universitätsklinikum Schleswig-Holstein Institut fur Klinische Chermie
-
Mannheim, Germany, 68167
- Universitatsklinikum Mannheim GmBH, Frauenklinik
-
Mönchengladbach, Germany, 41061
- EV. Krankenhaus Bethesda - Johanniter GmbH, Station 1 Brustzentrum Niederrhein
-
München, Germany, 80637
- Rotkreuzklinikum Munchen Frauenklinik
-
München, Germany, 81675
- Klinik und Poliklinik für Frauenheilkunde
-
Münster, Germany, 48149
- Universitätsklinikum Münster, Bereich Senologie an der klinik fur Frauenheilkunde und Gerburtschilfe
-
Tübingen, Germany, 72076
- Universitätsklinikum Tübingen
-
Wiesbaden, Germany, 65189
- St. Josefs-Hospital Wiesbaden GmbH, Gynakologie und Geburtshilfe
-
-
-
-
-
Hong Kong, Hong Kong
- Tuen Mun Hospital
-
Hong Kong, Hong Kong
- Hong Kong Sanatorium and Hospital
-
Hong Kong, Hong Kong, 999077
- Department of Medicine, Queen Mary Hospital
-
New Territories, Hong Kong, 999077
- Prince of Wales Hospital - Hong Kong
-
-
-
-
-
Budapest, Hungary, 1122
- Orszagos Onkologiai Intezet
-
Budapest, Hungary, 1145
- Uzsoki Utcai Kórház
-
Debrecen, Hungary, 4032
- Debreceni Egyetem Klinikai Kozpont
-
Győr, Hungary, 9024
- Petz Aladár Egyetemi Oktató Kórház - Gy?r
-
-
-
-
-
Beersheba, Israel, 8410101
- Soroka Medical Center
-
Haifa, Israel, 3109601
- Rambam Health Care Campus
-
Jerusalem, Israel, 9103102
- Shaare Zedek Medical Center
-
Jerusalem, Israel
- Hadassah - Hebrew University Medical Center
-
Kfar Saba, Israel, 4428164
- Meir Medical Center
-
Petah Tikva, Israel, 4941492
- Rabin Medical Center
-
Rehovot, Israel, 7661041
- Kaplan Medical Center
-
Tel Aviv, Israel, 64239
- Tel Aviv Sourasky Medical Center
-
Tel Aviv, Israel, 52621
- Sheba Medical Center Hospital - Tel Hashomer
-
-
-
-
-
Bari, Italy, 70124
- IRCCS Istituto Tumori "Giovanni Paolo II"
-
Bologna, Italy
- SSD Oncologia Medica Addarii-Zamagni, IRCSS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant'Orsola
-
Brescia, Italy, 25123
- UO Oncologia, ASST degli Spedali Civili di Brescia
-
Genova GE, Italy, 16132
- IRCCS Ospedale Policlinico San Martino
-
Lecco, Italy, 23900
- S.C. Oncologia medica, ASST di Lecco
-
Lucca, Italy, 55100
- Presidio Ospedaliero di Lucca
-
Macerata, Italy, 62100
- Ospedale Generale Provinciale - Macerata
-
Milan, Italy, 20132
- Ospedale San Raffaele
-
Milan, Italy, 20141
- Istituto Europeo di Oncologia
-
Milan, Italy, 20133
- Fondazione IRCCS - Istituto Nazionale dei Tumori
-
Monza, Italy, 20090
- Centro Ricerca Fase I, Fondazione IRCSS San Gerado dei Tintori
-
Napoli, Italy, 80131
- AOU "Luigi Vanvitelli"
-
Napoli, Italy, 80131
- Oncologia Medica Senologica Sperimentale - Istituto Nazionale Tumori IRCCS Fondazione G. Pascale
-
Novara, Italy, 28100
- Aou Maggiore Della Carita
-
Padua, Italy, 35128
- Istituto Oncologico Veneto - IRCCS
-
Prato, Italy, 59100
- S.O.C Oncologia Medica, Nuovo Ospedale di Prato Santo Stefano
-
Roma, Italy, 00161
- Policlinico di Roma
-
Rome, Italy, 00168
- Fondazione Policlinico Universitario Agostino Geme
-
Siena, Italy, 53100
- Azienda Ospedaliera Universitaria Senese - Losped
-
-
-
-
-
Aichi, Japan, 464-8681
- Aichi Cancer Center Hospital
-
Aoba-ku, Japan, 980-8574
- Tohoku University Hospital
-
Bunkyō City, Japan, 113-8431
- Juntendo University Hospital
-
Chūōku, Japan, 260-8717
- Chiba Cancer Center
-
Chūōku, Japan, 541-8567
- Osaka Prefectural Hospital Organization Osaka International Cancer Institute
-
Ehime, Japan, 791-0280
- Nho Shikoku Cancer Center
-
Fukushima, Japan
- Fukushima Medical University Hospital
-
Inamachi, Japan, 362-0806
- Saitama Cancer Center
-
Kagoshima, Japan, 892-0833
- Hakuaikai Sagara Hospital
-
Kanagawa, Japan, 259-1193
- Tokai University Hospital
-
Kashiwa, Japan, 277-8577
- National Cancer Center Hospital East
-
Kumamoto, Japan, 860-8556
- Kumamoto University Hospital
-
Kure, Japan, 737-0023
- Kure Medical Center and Chugoku Cancer Center
-
Kōtoku, Japan, 135-8550
- The Cancer Institute Hospital Of JFCR
-
Mie, Japan, 514-8507
- Mie University Hospital
-
Nagoya, Japan, 466-8560
- Nagoya University Hospital
-
Nagoya, Japan, 467-8602
- Nagoya City University Hospital
-
Nakaku, Japan, 730-8518
- Hiroshima City Hiroshima Citizens Hospital
-
Niigata, Japan, 951-8566
- Niigata Cancer Center Hospital
-
Okayama, Japan, 700-8558
- Okayama University Hospital
-
Sakyo-ku, Japan, 606-8507
- Kyoto University Hospital
-
Sapporo, Japan, 003-0804
- Hokkaido Cancer Center
-
Shizuoka, Japan, 411-8777
- Shizuoka Cancer Center
-
Shizuoka, Japan, 420-8527
- Shizuoka General Hospital
-
Suita, Japan, 565-0871
- Osaka University Hospital
-
Tokyo, Japan, 142-8555
- Showa University Hospital
-
Yokohama, Japan, 241-8515
- Kanagawa Cancer Center
-
Ōta-ku, Japan, 373-8550
- Gunma Prefectural Cancer Center
-
-
-
-
-
George Town, Malaysia, 10450
- Hospital Pulau Pinang
-
Johor Bahru, Malaysia, 81100
- Hospital Sultan Ismail
-
Kuala Lumpur, Malaysia, 59100
- University Malaya Medical Centre (UMMC)
-
Kuala Lumpur, Malaysia, 59100
- Pantai Hospital Kuala Lumpur
-
Kuala Lumpur, Malaysia, 47500
- Hospital Kuala Lumpur
-
Putrajaya, Malaysia, 62250
- Institut Kanser Negara
-
Sabak Bernam, Malaysia, 88996
- Hospital Wanita Dan Kanak-Kanak Sabah
-
Sarawak, Malaysia, 93586
- Sarawak General Hospital
-
-
-
-
-
Chihuahua City, Mexico, 31000
- Icaro Investigaciones en Medicina S.A. de C.V.
-
Culiacán, Mexico, 80230
- Centro para el Desarrollo de la Medicina
-
Guadalajara, Mexico, 44670
- PanAmerican Clinical Research Mexico - Guadalajara
-
Mexico City, Mexico, 06100
- Cryptex Investigación Clínica
-
Monterrey, Mexico, 64710
- Avix Investigacion Clinica S.C.
-
Mérida, Mexico, 97070
- Medical Care and Research S.A. de C.V
-
México, Mexico, 4980
- Fucam A.C.
-
San Luis Potosí City, Mexico, 78209
- Oncológico Potosino
-
Veracruz, Mexico, 91900
- FAICIC Clínical Research
-
Zapopan, Mexico, 45070
- iBiomed - Investigacion Biomedica para el Desarrol
-
-
-
-
-
Breda, Netherlands, 4818 CK
- Amphia Ziekenhuis - Breda Langendijk
-
Groningen, Netherlands, 9700 RB
- Universitair Medisch Centrum Groningen
-
Leeuwarden, Netherlands, 8934 AD
- Medisch Centrum Leeuwarden
-
Rotterdam, Netherlands
- Erasmus Medisch Centrum
-
-
-
-
-
Gdansk, Poland, 80-952
- Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii
-
Gliwice, Poland, 44-102
- Narodowy Instytut Onkologii im. Marii Sklodowskiej
-
Opole, Poland, 45-061
- SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego
-
Poznan, Poland, 61- 866
- Wielkopolskie Centrum Onkologii im. Marii Sklodowskiej-Curie
-
Siedlce, Poland, 08-110
- Mazowiecki Szpital Wojewódzki im. w. Jana Pawa II w
-
Warsaw, Poland, 04-141
- Wojskowy Instytut Medyczny
-
Warsaw, Poland, 02-781
- Narodowy Instytut Onkologii im.Marii Marii Sklodowskiejs
-
-
-
-
PR
-
Ponce, PR, Puerto Rico, 00716
- Ponce Medical School Foundation Inc.
-
-
-
-
-
Hilton, South Africa, 3245
- Hopelands Cancer Centre
-
Johannesburg, South Africa, 2196
- The Medical Oncology Centre of Rosebank
-
Pretoria, South Africa, 0002
- University Of Pretoria
-
-
-
-
-
Goyang-si Gyeonggi-do, South Korea, 10408
- National Cancer Center - Korea
-
Seongnam-si, South Korea, 13620
- Seoul National University Bundang Hospital
-
Seoul, South Korea, 05505
- Asan Medical Center
-
Seoul, South Korea, 06351
- Samsung Medical Center
-
Seoul, South Korea, 03722
- Severance Hospital
-
Seoul, South Korea, 3080
- Seoul National University Hospital
-
Seoul, South Korea, 2841
- Korea University Anam Hospital
-
Seoul, South Korea, 6591
- The Catholic University of Korea, Seoul St. Mary's Hospital
-
-
-
-
-
A Coruña, Spain, 15006
- Hospital Teresa Herrera - Materno Infantil
-
Barcelona, Spain, 08036
- Hospital Clinic De Barcelona
-
Barcelona, Spain, 08028
- Hospital Universitari Dexeus
-
Barcelona, Spain, 8035
- Hospital Universitari Vall d'Hebron
-
Barcelona, Spain, 08036
- Hospital Clínic Barcelona
-
Barcelona, Spain, 8023
- Hospital De La Santa Creu I Sant Pau
-
Bilbao, Spain, 48013
- Hospital Universitario de Basurto
-
Lleida, Spain, 25198
- Hospital Universitari Arnau de Vilanova
-
Madrid, Spain, 28040
- Hospital Universitario Fundacion Jimenez Diaz
-
Madrid, Spain, 28007
- Hospital General Universitario Gregorio Marañón
-
Madrid, Spain, 28033
- MD Anderson Cancer Centre Madrid
-
Murcia, Spain, 30008
- Hospital General Universitario Morales Meseguer
-
Málaga, Spain, 29010
- Hospital Universitario Virgen de la Victoria
-
Santa Cruz de Tenerife, Spain, 38320
- Hospital Universitario de Canarias
-
Seville, Spain, 41013
- Hospital Unviersitario Virgen del Rocio
-
Seville, Spain, 41071
- Hospital Universitario Virgen Macarena
-
Valencia, Spain, 46010
- Hospital Clinico Universitario de Valencia
-
-
-
-
-
Baden, Switzerland, 5404
- Kantonsspital Baden
-
Liestal, Switzerland, 4410
- Kantonsspital Baselland - Standort Liestal
-
Sankt Gallen, Switzerland, 9007
- Kantonsspital Sankt Gallen
-
Winterthur, Switzerland, 8401
- Kantonsspital Winterthur
-
Zurich, Switzerland, 8008
- Brust-Zentrum Zürich
-
-
-
-
-
Changhua, Taiwan, 50006
- Changhua Christian Hospital
-
Kaohsiung City, Taiwan, 807
- Kaohsiung Medical University Chung-Ho Memorial Hospital
-
New Taipei City, Taiwan, 235
- Taipei Medical University-Shuang Ho Hospital
-
Tainan City, Taiwan, 73657
- Chi Mei Hospital, Liouying
-
Tainan City, Taiwan, 704
- National Cheng Kung University Hospital
-
Taipei, Taiwan, 100
- National Taiwan University Hospital
-
Taipei, Taiwan, 11217
- Taipei Veterans General Hospital
-
Taoyuan District, Taiwan, 333
- Linkou Chang Gung Memorial Hospital
-
-
-
-
-
Adana, Turkey (Türkiye), 1120
- Baskent Uni. Dr Turgut Noyan Uyg. ve Aras. Merkezi
-
Ankara, Turkey (Türkiye), 6010
- Ankara Il Saglik Mudurlugu SBU Gulhane Egitim Ve A
-
Ankara, Turkey (Türkiye)
- Hacettepe Universitesi Hastanesi
-
Ankara, Turkey (Türkiye), 6200
- Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
-
Ankara, Turkey (Türkiye), 6520
- Memorial Ankara Hastanesi
-
Edirne, Turkey (Türkiye), 22030
- Trakya Universitesi Tip Fakultesi Hastanesi
-
Istanbul, Turkey (Türkiye), 34000
- Istanbul Il Saglik Mudurlugu Goztepe Prof. Dr. Sul
-
Istanbul, Turkey (Türkiye), 34214
- Medipol Mega Universite Hastanesi
-
Izmir, Turkey (Türkiye), 35100
- Ege Universitesi Hastanesi
-
Izmir, Turkey (Türkiye), 35575
- Medicana International Izmir Hastanesi
-
Sarıyer, Turkey (Türkiye)
- Acibadem Maslak Hastanesi
-
Şişli, Turkey (Türkiye), 34365
- VKV Amerikan Hastanesi
-
-
-
-
-
Edinburgh, United Kingdom, EH4 2XU
- NHS Lothian
-
Glasgow, United Kingdom, G12 0YN
- Clinical Trials Unit Lvl 0 Cancer Research UK Beatson Institute
-
Leeds, United Kingdom, LS9 7TF
- Leeds Teaching Hospitals NHS Trust
-
London, United Kingdom, SE1 9RT
- Guy's and Saint Thomas' NHS Foundation Trust
-
London, United Kingdom, WC1E 6BT
- University College London Hospitals
-
London, United Kingdom, EC1M 6BQ
- : Barts Health NHS Trust, St Hospital
-
London, United Kingdom, NW2 2QG
- Royal Free London NHS Foundation Trust
-
Nottingham, United Kingdom, NG5 1PB
- Nottingham University Hospitals NHS Trust
-
-
-
-
Alaska
-
Anchorage, Alaska, United States, 99508
- Alaska Oncology and Hematology
-
-
Arizona
-
Tucson, Arizona, United States, 85711
- Arizona Oncology Associates, PC-Hope
-
Tucson, Arizona, United States, 85704
- Arizona Oncology Associates, PC-Hope,1845 W Orange Grove Rd
-
Tucson, Arizona, United States, 85704
- Arizona Oncology Associates, PC-Hope,2070 W. Rudasill Rd.
-
Tucson, Arizona, United States, 85745
- Arizona Oncology Associates, PC-Hope,1620 West St. Mary's Road
-
-
Arkansas
-
Hot Springs, Arkansas, United States, 71913
- Genesis Cancer and Blood Institute
-
Hot Springs, Arkansas, United States, 71914
- Genesis Cancer and Blood Institute,1456 Higdon Ferry Road Suite B.
-
Jonesboro, Arkansas, United States, 72401
- Saint Bernards Medical Center
-
Paragould, Arkansas, United States, 72450
- Saint Bernards Medical Center,4000 Linwood Drive
-
-
California
-
Burbank, California, United States, 91505
- University of California Los Angeles - Jonsson Comprehensive Cancer Center,201 S. Buena Vista Street, Suite 200
-
Costa Mesa, California, United States, 92627
- University of California Irvine Health Chao Family,1640 Newport Blvd
-
Duarte, California, United States, 91010
- City of Hope
-
La Jolla, California, United States, 92093
- University of California San Diego Moores Cancer
-
Laguna Hills, California, United States, 91505
- University of California Los Angeles - Jonsson Comprehensive Cancer Center,24302 Paseo de Valencia, Suite 200
-
Los Alamitos, California, United States, 90720
- Cancer and Blood Specialty Clinic
-
Newport, California, United States, 92660
- City of Hope,1601 Avocado Ave
-
Orange, California, United States, 92868
- University of California Irvine Health Chao Family
-
Pasadena, California, United States, 91030
- City of Hope,209 Fair Oaks Ave
-
San Luis Obispo, California, United States, 93401
- University of California Los Angeles - Jonsson Comprehensive Cancer Center,892 Aerovista Place, Suite 240
-
Santa Barbara, California, United States, 93105
- Sansum Clinic
-
Santa Monica, California, United States, 90404
- University of California Los Angeles - Jonsson Comprehensive Cancer Center,2020 Santa Monica Blvd, Suite 600
-
Santa Monica, California, United States, 90404
- University of California Los Angeles - Jonsson Comprehensive Cancer Center,2336 Santa Monica, Suites 302 and 304
-
Santa Monica, California, United States, 90404
- University of California Los Angeles - Jonsson Comprehensive Cancer Center
-
Santa Rosa, California, United States, 95403
- St. Jude Hospital Yorba dba St. Joseph Heritage Healthcare
-
Solvang, California, United States, 93463
- Sansum Clinic,2040 Viborg Road
-
Torrance, California, United States, 90505
- Torrance Memorial Physician Network - Cancer Care
-
Torrance, California, United States, 90503
- City of Hope,5215 Torrance Blvd
-
Upland, California, United States, 91786
- City of Hope,1100 San Bernardino Rd
-
Westlake Village, California, United States, 91361
- University of California Los Angeles - Jonsson Comprehensive Cancer Center,1250 La Venta Dr, Suite 100
-
-
Colorado
-
Aurora, Colorado, United States, 80012
- Rocky Mountain Cancer Centers,1700 South Potomac Street
-
Boulder, Colorado, United States, 80303
- Rocky Mountain Cancer Centers
-
Colorado Springs, Colorado, United States, 80907
- Rocky Mountain Cancer Centers,2312 N. Nevada Avenue
-
Colorado Springs, Colorado, United States, 80923
- Rocky Mountain Cancer Centers,6031 E. Woodman Rd.
-
Denver, Colorado, United States, 80220
- Rocky Mountain Cancer Centers,4700 E. Hale Parkway
-
Lakewood, Colorado, United States, 80228
- Rocky Mountain Cancer Centers,11750 West 2nd Place
-
Littleton, Colorado, United States, 80120
- Rocky Mountain Cancer Centers,22 West Dry Creek Circle
-
Lone Tree, Colorado, United States, 80124
- Rocky Mountain Cancer Centers,10107 Ridge Gate Parkway
-
Longmont, Colorado, United States, 80124
- Rocky Mountain Cancer Centers,2030 Mountain View Ave Ste 210
-
Pueblo, Colorado, United States, 81008
- Rocky Mountain Cancer Centers,3676 Parker Blvd
-
Pueblo, Colorado, United States, 81008
- Rocky Mountain Cancer Centers,525 W. 15th Street
-
Thornton, Colorado, United States, 80260
- Rocky Mountain Cancer Centers,8820 Huron Street
-
-
Connecticut
-
Norwich, Connecticut, United States, 06360
- Eastern Connecticut Hematology and Oncology Associates
-
-
Florida
-
Altamonte Springs, Florida, United States, 32701
- Advent Health Medical Group
-
Altamonte Springs, Florida, United States, 32701
- SCRI - Florida Cancer Specialists - North Region R,750 Orienta Ave
-
Aventura, Florida, United States, 33180
- University of Miami - Sylvester Comprehensive Cancer Center,2801 NE 213th St
-
Bonita Springs, Florida, United States, 34135
- Florida Cancer Specialists,9776 Bonita Beach Road Southeast Suite 201 A
-
Bradenton, Florida, United States, 34205
- Florida Cancer Specialists,3630 Manatee Avenue West
-
Bradenton, Florida, United States, 34211
- Florida Cancer Specialists,5985 Silver Falls Run
-
Brandon, Florida, United States, 33511
- SCRI - Florida Cancer Specialists - North Region R,403 S. Kings Ave.
-
Cape Coral, Florida, United States, 33909
- Florida Cancer Specialists,1030 Commerce Creek Blvd
-
Clearwater, Florida, United States, 33761
- SCRI - Florida Cancer Specialists - North Region R,3280 McMullen Booth Road
-
Coral Gables, Florida, United States, 33146
- University of Miami - Sylvester Comprehensive Cancer Center,5555 Ponce De Leon Blvd
-
Daytona Beach, Florida, United States, 32117
- SCRI - Florida Cancer Specialists - West Palm Beach,224 Memorial Medical Parkway, Suite 300
-
Deerfield Beach, Florida, United States, 33442
- University of Miami - Sylvester Comprehensive Cancer Center,1192 East Newport Center Drive
-
Fort Myers, Florida, United States, 33901
- Florida Cancer Specialists
-
Fort Myers, Florida, United States, 33905
- Florida Cancer Specialists,8981 Colonial Center Drive
-
Fort Myers, Florida, United States, 33908
- Florida Cancer Specialists,8260 Gladiolus Dr
-
Gainesville, Florida, United States, 32605
- SCRI - Florida Cancer Specialists - North Region R,6420 W. Newberry Road
-
Hollywood, Florida, United States, 33021
- University of Miami - Sylvester Comprehensive Cancer Center,3850 Hollywood Blvd
-
Largo, Florida, United States, 33770
- SCRI - Florida Cancer Specialists - North Region R,100 Highland Avenue
-
Lecanto, Florida, United States, 34461
- SCRI - Florida Cancer Specialists - North Region R,521 North Lecanto Highway
-
Miami, Florida, United States, 33136
- University of Miami - Sylvester Comprehensive Cancer Center
-
Miami, Florida, United States, 33136
- University of Miami - Sylvester Comprehensive Cancer Center,1400 NW 12th Ave
-
Miami, Florida, United States, 33176
- University of Miami - Sylvester Comprehensive Cancer Center,8932 S.W. 97 Ave
-
Naples, Florida, United States, 34102
- Florida Cancer Specialists,1100 Goodlette Road
-
Ocala, Florida, United States, 34474
- SCRI - Florida Cancer Specialists - North Region R,4945 SW 49th Place
-
Orange City, Florida, United States, 32763
- SCRI - Florida Cancer Specialists - North Region R,2824 Enterprise Rd
-
Orlando, Florida, United States, 32804
- Advent Health Medical Group,2501 North Orange Ave
-
Orlando, Florida, United States, 32806
- SCRI - Florida Cancer Specialists - North Region R,70 W. Gore Street
-
Plantation, Florida, United States, 33324
- University of Miami - Sylvester Comprehensive Cancer Center,8100 SW 10 Street
-
Port Charlotte, Florida, United States, 33980
- Florida Cancer Specialists,22395 Edgewater Drive
-
Sarasota, Florida, United States, 34232
- Florida Cancer Specialists,600 North Cattlemen Road
-
Sarasota, Florida, United States, 34236
- Florida Cancer Specialists,1970 Golf Street
-
Spring Hill, Florida, United States, 34608
- SCRI - Florida Cancer Specialists - North Region R,7154 Medical Center Drive
-
St. Petersburg, Florida, United States, 33705
- SCRI - Florida Cancer Specialists - North Region R,1201 Fifth Avenue North
-
St. Petersburg, Florida, United States, 33705
- SCRI - Florida Cancer Specialists - North Region R
-
Stuart, Florida, United States, 34994
- SCRI - Florida Cancer Specialists - West Palm Beach,301 SE Ocean Blvd, Suite 102
-
Tampa, Florida, United States, 33607
- SCRI - Florida Cancer Specialists - North Region R,3402 West Dr. Martin Luther King Jr. Boulevard
-
Tavares, Florida, United States, 32778
- SCRI - Florida Cancer Specialists - North Region R,4100 Waterman Way
-
The Villages, Florida, United States, 32159
- SCRI - Florida Cancer Specialists - North Region R,1400 US Highway 441 N
-
Trinity, Florida, United States, 34655
- SCRI - Florida Cancer Specialists - North Region R,9320 State Road 54
-
Venice, Florida, United States, 34292
- Florida Cancer Specialists,836 Sunset Lake Blvd
-
Vero Beach, Florida, United States, 32960
- SCRI - Florida Cancer Specialists - West Palm Beach,3730 7th Terrace, Suite 101
-
Wellington, Florida, United States, 33414
- SCRI - Florida Cancer Specialists - West Palm Beach,1037 S. State Road 7, Bldg B, Suite 303
-
West Palm Beach, Florida, United States, 33401
- SCRI - Florida Cancer Specialists - West Palm Beach
-
Winter Park, Florida, United States, 32789
- SCRI - Florida Cancer Specialists - North Region R,460 N Orlando Ave
-
-
Georgia
-
Athens, Georgia, United States, 30606
- Northside Hospital,125 King Avenue
-
Atlanta, Georgia, United States, 30322
- Winship Cancer Institute of Emory University
-
Atlanta, Georgia, United States, 30342
- Northside Hospital
-
Atlanta, Georgia, United States, 30214
- Piedmont Cancer Institute - Atlanta,1267 Hwy 54W
-
Atlanta, Georgia, United States, 30308
- Winship Cancer Institute of Emory University,550 Peachtree St NE
-
Atlanta, Georgia, United States, 30318
- Piedmont Cancer Institute - Atlanta
-
Atlanta, Georgia, United States, 30342
- Northside Hospital,5670 Peachtree Dunwoody Rd.
-
Atlanta, Georgia, United States, 30342
- Winship Cancer Institute of Emory University,5665 Peachtree Dunwoody Road
-
Blairsville, Georgia, United States, 30512
- Northside Hospital,308 Deep South Farm Rd, Suite 200
-
Canton, Georgia, United States, 30114
- Northside Hospital,228 Riverstone Dr.
-
Cumming, Georgia, United States, 30041
- Northside Hospital,1505 Northside Blvd, Suite 4600
-
Duluth, Georgia, United States, 30096
- Northside Hospital,3855 Pleasant Hill Rd., Suite 480
-
Macon, Georgia, United States, 31217
- Northside Hospital,308 Coliseum Dr.
-
Newnan, Georgia, United States, 30265
- Piedmont Cancer Institute - Atlanta,775 Poplar Road
-
Stockbridge, Georgia, United States, 30281
- Piedmont Cancer Institute - Atlanta,1240 Eagles Landing Pkwy
-
-
Illinois
-
Chicago, Illinois, United States, 60611
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
-
Chicago, Illinois, United States, 60612
- University of Illinois Hospital and Health Sciences System (Outpatient Cancer Center)
-
Chicago, Illinois, United States, 60657
- Orchard Healthcare Research Inc,2845 North Sheridan Road, 1st Floor
-
DeKalb, Illinois, United States, 60115
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University,1 Kish Hospital Drive
-
DeKalb, Illinois, United States, 60115
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University,10 Health Services Drive
-
Evanston, Illinois, United States, 60202
- Orchard Healthcare Research Inc,800 Austin Street, Suite 360, East Tower
-
Geneva, Illinois, United States, 60134
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University,300 Randall Road
-
Geneva, Illinois, United States, 60134
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University,304 Randall Road
-
Lake Forest, Illinois, United States, 60045
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University,1000 N. Westmoreland Road
-
Skokie, Illinois, United States, 60077
- Orchard Healthcare Research Inc
-
Warrenville, Illinois, United States, 25731
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University,4405 Weaver Parkway
-
Warrenville, Illinois, United States, 60555
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University,4455 Weaver Parkway
-
Winfield, Illinois, United States, 60190
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University,25 N Winfield Road
-
-
Indiana
-
Fort Wayne, Indiana, United States, 46845
- Regulatory Management Only: TRIO-US Central Administration
-
-
Kansas
-
Kansas City, Kansas, United States, 66160
- The University of Kansas Cancer Center,2000 Olathe Blvd
-
Overland Park, Kansas, United States, 66210
- The University of Kansas Cancer Center,12200 W. 110th Street
-
Overland Park, Kansas, United States, 66211
- The University of Kansas Cancer Center,10710 Nall Avenue
-
Overland Park, Kansas, United States, 66211
- The University of Kansas Cancer Center,10730 Nall Avenue
-
Westwood, Kansas, United States, 66205
- The University of Kansas Cancer Center
-
-
Kentucky
-
Louisville, Kentucky, United States, 40207
- Norton Cancer Institute - Saint Matthews
-
Louisville, Kentucky, United States, 40202
- Norton Cancer Institute - Saint Matthews,234 E. Gray Strret
-
Louisville, Kentucky, United States, 40202
- Norton Cancer Institute - Saint Matthews,676 S. Floyd Street
-
Louisville, Kentucky, United States, 40241
- Norton Cancer Institute - Saint Matthews,4955 Norton Healthcare Blvd
-
-
Louisiana
-
Baton Rouge, Louisiana, United States, 70809
- Hematology Oncology Clinic - Baton Rouge
-
Zachary, Louisiana, United States, 70791
- Hematology Oncology Clinic - Baton Rouge,1673 E Mount Please Drive
-
-
Maryland
-
Baltimore, Maryland, United States, 21229
- Cancer Institute Ascension Saint Agnes
-
-
Massachusetts
-
Boston, Massachusetts, United States, 02215
- Beth Israel Deaconess Medical Center
-
Boston, Massachusetts, United States, 02215
- Dana-Farber Cancer Institute
-
Boston, Massachusetts, United States, 02215
- Massachusetts General Hospital
-
Danvers, Massachusetts, United States, 01923
- Massachusetts General Hospital,102 Endicott Street
-
Newton, Massachusetts, United States, 02462
- Massachusetts General Hospital,2014 Washington St
-
-
Michigan
-
Ann Arbor, Michigan, United States, 48109
- University of Michigan
-
Grosse Pointe Woods, Michigan, United States, 48236
- Ascension St. John Hospital
-
Southfield, Michigan, United States, 48075
- Ascension Providence Hospital Southfield Cancer Center
-
-
Minnesota
-
Rochester, Minnesota, United States, 55905
- Mayo Clinic
-
-
Mississippi
-
Southaven, Mississippi, United States, 38671
- The West Clinic, PLLC dba West Cancer Center,7668 Airways Blvd
-
-
Missouri
-
Kansas City, Missouri, United States, 64116
- The University of Kansas Cancer Center,2750 Clay Edwards Drive
-
Kansas City, Missouri, United States, 64154
- The University of Kansas Cancer Center,8700 North Green Hills Road
-
Lee's Summit, Missouri, United States, 64064
- The University of Kansas Cancer Center,4881 N.E. Goodview Circle
-
-
Nebraska
-
Grand Island, Nebraska, United States, 68803
- Nebraska Cancer Specialists,2730 W. Faidley Ave
-
Omaha, Nebraska, United States, 68130
- Nebraska Cancer Specialists
-
Omaha, Nebraska, United States, 68114
- Nebraska Cancer Specialists,8303 Dodge Street
-
Papillion, Nebraska, United States, 68046
- Nebraska Cancer Specialists,611 Fenwick Dr
-
-
Nevada
-
Henderson, Nevada, United States, 89052
- Comprehensive Cancer Centers of Nevada - Central V,10001 S. Eastern Avenue, Suite 108
-
Henderson, Nevada, United States, 89052
- Comprehensive Cancer Centers of Nevada - Central V,2460 W. Horizon Ridge Parkway
-
Henderson, Nevada, United States, 89074
- Comprehensive Cancer Centers of Nevada - Central V,1501 Wigwam Parkway, Suite 1300
-
Las Vegas, Nevada, United States, 89144
- Comprehensive Cancer Centers of Nevada - Central V,653 North Town Center Drive, Suite 402
-
Las Vegas, Nevada, United States, 89148
- Comprehensive Cancer Centers of Nevada - Central V,9280 W. Sunset Road Suite 100
-
Las Vegas, Nevada, United States, 89169
- Comprehensive Cancer Centers of Nevada - Central V,7445 Peak Drive
-
Las Vegas, Nevada, United States, 89169
- Comprehensive Cancer Centers of Nevada - Central V
-
-
New Jersey
-
Berkeley Heights, New Jersey, United States, 07922
- Summit Medical Group,1 Diamond Hill Road
-
East Brunswick, New Jersey, United States, 08816
- Regional Cancer Care Associates - East Brunswick
-
Florham Park, New Jersey, United States, 07932
- Summit Medical Group
-
Hackensack, New Jersey, United States, 07601
- John Theurer Cancer Center
-
Hamilton, New Jersey, United States, 08690
- Rutgers Cancer Institute of New Jersey,2575 Klockner Road
-
Jersey City, New Jersey, United States, 07302
- Rutgers Cancer Institute of New Jersey,414 Grand Street
-
Lakewood, New Jersey, United States, 08701
- Rutgers Cancer Institute of New Jersey,600 River Avenue
-
Livingston, New Jersey, United States, 07039
- Rutgers Cancer Institute of New Jersey,94 Old Short Hills Road
-
Long Branch, New Jersey, United States, 07740
- Rutgers Cancer Institute of New Jersey,300 Second Ave
-
Monroe, New Jersey, United States, 08831
- Regional Cancer Care Associates - East Brunswick,9 Centre Drive
-
New Brunswick, New Jersey, United States, 08901
- Rutgers Cancer Institute of New Jersey
-
New Brunswick, New Jersey, United States, 08820
- Regional Cancer Care Associates - East Brunswick,34-36 Progress Street
-
Newark, New Jersey, United States, 07103
- Rutgers Cancer Institute of New Jersey,150 Bergen St.
-
Newark, New Jersey, United States, 07112
- Rutgers Cancer Institute of New Jersey,201 Lyons Avenue
-
Somerset, New Jersey, United States, 08873
- Regional Cancer Care Associates - East Brunswick,75 Veronica Avenue
-
Somerville, New Jersey, United States, 08876
- Rutgers Cancer Institute of New Jersey,110 Rehill Ave
-
Toms River, New Jersey, United States, 08755
- Rutgers Cancer Institute of New Jersey,99 Highway 37 West
-
West Long Branch, New Jersey, United States, 07764
- Rutgers Cancer Institute of New Jersey,100 State Route 36
-
-
New York
-
Babylon, New York, United States, 11702
- New York Cancer & Blood Specialists - Port Jeffers,72 East Main St.
-
Mineola, New York, United States, 11501
- Perlmutter Cancer Center - Manhattan - 34th Street,259 First Street
-
New Hyde Park, New York, United States, 11042
- New York Cancer & Blood Specialists - Port Jeffers,1 Delaware Dr.
-
New York, New York, United States, 10016
- Perlmutter Cancer Center - Manhattan - 34th Street
-
New York, New York, United States, 10032
- NYP/Columbia Univeresity Medical Center/Herbert Irving Comprehensive Cancer Center
-
Patchogue, New York, United States, 11772
- New York Cancer & Blood Specialists - Port Jeffers,365 East Main St.
-
Port Jefferson, New York, United States, 11776
- New York Cancer & Blood Specialists - Port Jeffers,1500 Rte, 112, Building 4
-
Port Jefferson Station, New York, United States, 11776
- New York Cancer & Blood Specialists - Port Jeffers,49 Rte. 347, Newconset Hwy
-
Port Jefferson Station, New York, United States, 11776
- New York Cancer & Blood Specialists - Port Jeffers
-
Riverhead, New York, United States, 11901
- New York Cancer & Blood Specialists - Port Jeffers,750 Old County Rd. Suite 4
-
The Bronx, New York, United States, 10028
- New York Cancer & Blood Specialists - Port Jeffers,12 East 86th St, Suite 4
-
The Bronx, New York, United States, 10469
- New York Cancer & Blood Specialists - Port Jeffers,2330 Eastchester Road, Suite 360
-
The Bronx, New York, United States, 10467
- Montefiore Medical Center - Montefiore Medical Park
-
-
Ohio
-
Columbus, Ohio, United States, 43219
- Zangmeister Cancer Center
-
Columbus, Ohio, United States, 43212
- The Ohio State University Wexner Medical Center Clinical Laboratories
-
-
Oregon
-
Portland, Oregon, United States, 97213
- Northwest Cancer Specialists, PC,5050 NE Hoyt St.
-
Portland, Oregon, United States, 97227
- Northwest Cancer Specialists, PC,265 N. Broadway
-
Tigard, Oregon, United States, 97223
- Northwest Cancer Specialists, PC
-
-
Pennsylvania
-
Bethel Park, Pennsylvania, United States, 15102
- Magee-Womens Hospital of UPMC,200 Oxford Drive
-
Cranberry Township, Pennsylvania, United States, 16066
- Magee-Womens Hospital of UPMC,3 St. Francis Way
-
Erie, Pennsylvania, United States, 16505
- Magee-Womens Hospital of UPMC,2500 West 12th Street
-
Erie, Pennsylvania, United States, 16550
- Magee-Womens Hospital of UPMC,201 State Street, 6 Main
-
Greensburg, Pennsylvania, United States, 15601
- Magee-Womens Hospital of UPMC,200 Village Drive
-
Monroeville, Pennsylvania, United States, 15146
- Magee-Womens Hospital of UPMC,400 Oxford Drive
-
Philadelphia, Pennsylvania, United States, 19104
- University of Pennsylvania Abramson Cancer Center
-
Pittsburgh, Pennsylvania, United States, 15213
- Magee-Womens Hospital of UPMC
-
Pittsburgh, Pennsylvania, United States, 15232
- Magee-Womens Hospital of UPMC,5115 Centre Avenue
-
Pittsburgh, Pennsylvania, United States, 15237
- Magee-Womens Hospital of UPMC,9100 Babcock Boulevard
-
Pittsburgh, Pennsylvania, United States, 15213
- Magee-Womens Hospital of UPMC,300 Halket Street
-
Seneca, Pennsylvania, United States, 16346
- Magee-Womens Hospital of UPMC,100 Fairfield Dr
-
Washington, Pennsylvania, United States, 15301
- Magee-Womens Hospital of UPMC,470 Johnson Road
-
York, Pennsylvania, United States, 17408
- Magee-Womens Hospital of UPMC,1703 Innovation Drive
-
-
Rhode Island
-
Providence, Rhode Island, United States, 02903
- Rhode Island Hospital
-
Providence, Rhode Island, United States, 02906
- Rhode Island Hospital,164 Summit Ave, Fain 275A
-
-
Tennessee
-
Dickson, Tennessee, United States, 37055
- Tennessee Oncology, PLLC,103 Natchez Park Drive
-
Franklin, Tennessee, United States, 37067
- Tennessee Oncology, PLLC,4488 Carothers Parkway
-
Gallatin, Tennessee, United States, 37066
- Tennessee Oncology, PLLC,225 Big Station Camp Blvd
-
Germantown, Tennessee, United States, 38138
- The West Clinic, PLLC dba West Cancer Center
-
Hendersonville, Tennessee, United States, 37075
- Tennessee Oncology, PLLC,353 New Shackle Island Road
-
Hermitage, Tennessee, United States, 37076
- Tennessee Oncology, PLLC,5653 First Blvd.
-
Lebanon, Tennessee, United States, 37090
- Tennessee Oncology, PLLC,103 Physicians Way
-
Murfreesboro, Tennessee, United States, 37129
- Tennessee Oncology, PLLC,1840 Medical Center Parkway
-
Nashville, Tennessee, United States, 37203
- Tennessee Oncology, PLLC
-
Nashville, Tennessee, United States, 37203
- Tennessee Oncology, PLLC,2004 Hayes Street
-
Nashville, Tennessee, United States, 37203
- Tennessee Oncology, PLLC,SCRI Oncology Partners
-
Nashville, Tennessee, United States, 37205
- Tennessee Oncology, PLLC,4220 Harding Rd
-
Nashville, Tennessee, United States, 37207
- Tennessee Oncology, PLLC,3443 Dickerson Road
-
Nashville, Tennessee, United States, 37211
- Tennessee Oncology, PLLC,397 Wallace Road
-
Shelbyville, Tennessee, United States, 37160
- Tennessee Oncology, PLLC,120 Frank Martin Road
-
Smyrna, Tennessee, United States, 37167
- Tennessee Oncology, PLLC,300 Stonecrest Blvd
-
-
Texas
-
Arlington, Texas, United States, 76104
- The Center for Cancer and Blood Disorders - Magnolia,515 W. Mayfield Rd.
-
Austin, Texas, United States, 78731
- Texas Oncology-Austin
-
Austin, Texas, United States, 78705
- Texas Oncology-Austin,901 West 38th Street
-
Austin, Texas, United States, 78745
- Texas Oncology-Austin,4101 James Casey, Suite 100
-
Burleson, Texas, United States, 76028
- The Center for Cancer and Blood Disorders - Magnolia,11805 South Freeway
-
Dallas, Texas, United States, 75246
- Texas Oncology-Baylor Charles A. Sammons Cancer Center
-
Denison, Texas, United States, 75020
- Texas Oncology-Denison
-
Fort Worth, Texas, United States, 76104
- The Center for Cancer and Blood Disorders - Magnolia
-
Houston, Texas, United States, 77030
- University of Texas MD Anderson Cancer Center
-
Houston, Texas, United States, 77030
- Oncology Consultants
-
Houston, Texas, United States, 77008
- Oncology Consultants,1631 North Loop West
-
Houston, Texas, United States, 77024
- Oncology Consultants,925 Gessner
-
Houston, Texas, United States, 77030
- University of Texas MD Anderson Cancer Center,1155 Pressler St
-
San Antonio, Texas, United States, 78229
- Mays Cancer Center
-
Weatherford, Texas, United States, 76086
- The Center for Cancer and Blood Disorders - Magnolia,920 Santa Fe Drive
-
-
Utah
-
Farmington, Utah, United States, 84025
- Huntsman Cancer Institute, University of Utah,165 North University Avenue
-
Salt Lake City, Utah, United States, 84112
- Huntsman Cancer Institute, University of Utah
-
Salt Lake City, Utah, United States, 84106
- Huntsman Cancer Institute, University of Utah,1280 E. Stringham Avenue
-
South Jordan, Utah, United States, 84009
- Huntsman Cancer Institute, University of Utah,5126 West Daybreak Parkway
-
-
Virginia
-
Chesapeake, Virginia, United States, 23320
- Virginia Oncology Associates,744 N. Battlefield Blvd
-
Mechanicsville, Virginia, United States, 23116
- Virginia Cancer Institute,7501 Right Flank Road
-
Newport News, Virginia, United States, 23606
- Virginia Oncology Associates,1051 Loftis Blvd Suite 100
-
Norfolk, Virginia, United States, 23502
- Virginia Oncology Associates
-
Petersburg, Virginia, United States, 23805
- Virginia Cancer Institute,210 Medical Park Boulevard
-
Richmond, Virginia, United States, 23235
- Virginia Cancer Institute,1401 Johnston-Willis Drive
-
Richmond, Virginia, United States, 23298
- Virginia Cancer Institute
-
Virginia Beach, Virginia, United States, 23456
- Virginia Oncology Associates,1950 Glenn Mitchell Drive
-
-
Washington
-
Vancouver, Washington, United States, 98684
- Northwest Cancer Specialists, PC,210 SE 136th Avenue
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Description
Key Inclusion Criteria:
Individuals with locally advanced, inoperable, or metastatic triple-negative breast cancer (TNBC) who have not received previous systemic therapy for advanced disease and whose tumors are programmed cell death ligand 1 (PD-L1) positive at screening.
- Individuals must have completed treatment for Stage I to III breast cancer, if indicated, and ≥ 6 months must have elapsed between completion of treatment with curative intent and first documented local or distant disease recurrence.
- Individuals presenting with de novo metastatic TNBC are eligible for this study.
- TNBC status and tumor PD-L1 combined positive score (CPS) will be confirmed centrally on a recent or archival tumor specimen.
- Individuals must have measurable disease by computed tomography (CT) or magnetic resonance imaging (MRI) as per Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1 criteria as evaluated locally.
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1.
- Demonstrates adequate organ function
- Male and female individuals of childbearing potential who engage in heterosexual intercourse must agree to use protocol-specified method(s) of contraception.
- Individuals with HIV must be on antiretroviral therapy (ART) and have a well-controlled HIV infection/disease.
Key Exclusion Criteria:
- Positive serum pregnancy test or women who are lactating.
- Received prior therapy with an agent directed to another stimulatory or coinhibitory T-cell receptor.
- Individuals may not have received systemic anticancer treatment (with the exception of endocrine therapy) within the previous 6 months or radiation therapy within 2 weeks prior to enrollment.
- Individuals may not be participating in a study with an investigational agent or investigational device within 4 weeks prior to randomization. Individuals participating in observational studies are eligible.
- Have previously received topoisomerase 1 inhibitors or antibody drug conjugates containing a topoisomerase inhibitor.
- Have an active second malignancy.
- Have active serious infection requiring antibiotics.
- Individuals positive for HIV-1 or 2 with a history of Kaposi sarcoma and/or Multicentric Castleman Disease.
- Have active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.
- Has an active autoimmune disease that has required systemic treatment in the past 2 years.
Note: Other protocol defined Inclusion/Exclusion criteria may apply.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Experimental: Sacituzumab Govitecan-hziy (SG) + Pembrolizumab
Participants will receive SG 10 mg/kg on Days 1 and 8 of 21-day cycles and pembrolizumab 200 mg on Day 1 of 21-day cycles Pembrolizumab will be administered for a maximum of 35 cycles. |
Administered intravenously
Other Names:
Administered intravenously
Other Names:
|
|
Active Comparator: Pembrolizumab + Treatment of Physician's Choice (TPC)
Participants will receive pembrolizumab 200 mg on Day 1 of each 21-day cycle (maximum 35 cycles) plus TPC determined prior to randomization from 1 of the 3 allowed regimens:
|
Administered intravenously
Other Names:
Administered intravenously
Administered intravenously
Other Names:
Administered intravenously
Other Names:
Administered intravenously
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Progression-free Survival (PFS) as Assessed by Blinded Independent Central Review (BICR) per Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1
Time Frame: Randomization up to approximately 33 months
|
PFS is defined as the time from the date of randomization until the date of objective progressive disease (PD) or death (whichever comes first).
|
Randomization up to approximately 33 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Overall Survival (OS)
Time Frame: Randomization up to approximately 53 months
|
OS is defined as the time from the date of randomization until death due to any cause.
|
Randomization up to approximately 53 months
|
|
Objective Response Rate (ORR) as Assessed by BICR per RECIST Version 1.1
Time Frame: Randomization up to approximately 53 months
|
ORR is defined as the proportion of participants who achieve complete response (CR) or partial response (PR) that is confirmed at least 4 weeks after initial documentation of response.
|
Randomization up to approximately 53 months
|
|
Duration of Response (DOR) as Assessed by BICR per RECIST Version 1.1
Time Frame: Randomization up to approximately 53 months
|
DOR is defined as the time from the first documentation of CR or PR to the earlier of the first documentation of objective PD or death from any cause (whichever comes first).
|
Randomization up to approximately 53 months
|
|
Time to Response (TTR) as Assessed by BICR per RECIST Version 1.1
Time Frame: Randomization up to approximately 53 months
|
TTR is defined as the time from the date of randomization until the first documentation of CR or PR.
|
Randomization up to approximately 53 months
|
|
Percentage of Participants Experiencing Treatment-emergent Adverse Events (TEAEs)
Time Frame: First dose date up to 53 months plus 30 days
|
First dose date up to 53 months plus 30 days
|
|
|
Percentage of Participants Experiencing Clinical Laboratory Abnormalities
Time Frame: First dose date up to 53 months plus 30 days
|
First dose date up to 53 months plus 30 days
|
|
|
Time to Deterioration (TTD) in Global Health Status/Quality of Life (QoL) Scale as Measured by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Core Questionnaire, Version 3.0 (EORTC QLQ-C30)
Time Frame: Randomization up to approximately 53 months
|
The EORTC QLQ-C30 is a questionnaire to assess quality of life of cancer patients, it is composed of 30 questions (items) resulting in 5 functional scales, 1 global health status scale, 3 symptom scales, and 6 single items.
Scoring of the QLQ-C30 is performed according to QLQ-C30 Scoring manual.
All of the scales and single-item measures range in score from 0 to 100.
Higher score for the functioning scales and global health status denote a better level of functioning (i.e. a better state of the participant), while higher scores on the symptom and single-item scales indicate a higher level of symptoms (i.e. a worse state of the participant).
|
Randomization up to approximately 53 months
|
|
TTD of Pain Score as Measured by EORTC QLQ-C30
Time Frame: Randomization up to approximately 53 months
|
The EORTC QLQ-C30 is a questionnaire to assess quality of life of cancer patients, it is composed of 30 questions (items) resulting in 5 functional scales, 1 global health status scale, 3 symptom scales, and 6 single items.
Scoring of the QLQ-C30 is performed according to QLQ-C30 Scoring manual.
All of the scales and single-item measures range in score from 0 to 100.
Higher score for the functioning scales and global health status denote a better level of functioning (i.e. a better state of the participant), while higher scores on the symptom and single-item scales indicate a higher level of symptoms (i.e. a worse state of the participant).
|
Randomization up to approximately 53 months
|
|
TTD of Fatigue Score as Measured by EORTC QLQ-C30
Time Frame: Randomization up to approximately 53 months
|
The EORTC QLQ-C30 is a questionnaire to assess quality of life of cancer patients, it is composed of 30 questions (items) resulting in 5 functional scales, 1 global health status scale, 3 symptom scales, and 6 single items.
Scoring of the QLQ-C30 is performed according to QLQ-C30 Scoring manual.
All of the scales and single-item measures range in score from 0 to 100.
Higher score for the functioning scales and global health status denote a better level of functioning (ie, a better state of the participant), while higher scores on the symptom and single-item scales indicate a higher level of symptoms (ie, a worse state of the participant).
|
Randomization up to approximately 53 months
|
|
TTD of Physical Functioning Domain Score as Measured by EORTC QLQ-C30
Time Frame: Randomization up to approximately 53 months
|
The EORTC QLQ-C30 is a questionnaire to assess quality of life of cancer patients, it is composed of 30 questions (items) resulting in 5 functional scales, 1 global health status scale, 3 symptom scales, and 6 single items.
Scoring of the QLQ-C30 is performed according to QLQ-C30 Scoring manual.
All of the scales and single-item measures range in score from 0 to 100.
Higher score for the functioning scales and global health status denote a better level of functioning (ie, a better state of the participant), while higher scores on the symptom and single-item scales indicate a higher level of symptoms (ie, a worse state of the participant).
|
Randomization up to approximately 53 months
|
|
TTD of Role Functioning Score as Measured by EORTC QLQ-C30
Time Frame: Randomization up to approximately 53 months
|
The EORTC QLQ-C30 is a questionnaire to assess quality of life of cancer patients, it is composed of 30 questions (items) resulting in 5 functional scales, 1 global health status scale, 3 symptom scales, and 6 single items.
Scoring of the QLQ-C30 is performed according to QLQ-C30 Scoring manual.
All of the scales and single-item measures range in score from 0 to 100.
Higher score for the functioning scales and global health status denote a better level of functioning (ie, a better state of the participant), while higher scores on the symptom and single-item scales indicate a higher level of symptoms (ie, a worse state of the participant).
|
Randomization up to approximately 53 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Study Director: Gilead Study Director, Gilead Sciences
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Helpful Links
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
July 25, 2022
Primary Completion (Estimated)
February 1, 2027
Study Completion (Estimated)
February 1, 2027
Study Registration Dates
First Submitted
May 16, 2022
First Submitted That Met QC Criteria
May 16, 2022
First Posted (Actual)
May 19, 2022
Study Record Updates
Last Update Posted (Estimated)
September 18, 2025
Last Update Submitted That Met QC Criteria
September 16, 2025
Last Verified
September 1, 2025
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Neoplasms by Site
- Neoplasms
- Skin Diseases
- Breast Diseases
- Breast Neoplasms
- Skin and Connective Tissue Diseases
- Triple Negative Breast Neoplasms
- Amino Acids, Peptides, and Proteins
- Proteins
- Organic Chemicals
- Heterocyclic Compounds, 1-Ring
- Heterocyclic Compounds
- Hydrocarbons
- Cycloparaffins
- Hydrocarbons, Alicyclic
- Hydrocarbons, Cyclic
- Terpenes
- Coordination Complexes
- Taxoids
- Cyclodecanes
- Diterpenes
- Deoxycytidine
- Cytidine
- Pyrimidine Nucleosides
- Pyrimidines
- Albumins
- Albumin-Bound Paclitaxel
- Gemcitabine
- Carboplatin
- Paclitaxel
- pembrolizumab
- 130-nm albumin-bound paclitaxel
- sacituzumab govitecan
Other Study ID Numbers
- GS-US-592-6173
- 2021-005742-14 (EudraCT Number)
- KEYNOTE-D19 (Other Identifier: Merck Sharp & Dohme LLC)
- jRCT2041220123 (Registry Identifier: Japan Registry of Clinical Trials)
- MK-3475-D19 (Other Identifier: Merck Sharp & Dohme LLC)
- 2023-504194-21 (Other Identifier: European Medicines Agency)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Yes
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Triple Negative Breast Cancer
-
G1 Therapeutics, Inc.TerminatedBreast Cancer | Breast Neoplasm | Triple-Negative Breast Cancer | Triple-Negative Breast NeoplasmsUnited States, Bulgaria, Croatia, Slovenia, Serbia, Belgium, North Macedonia, Slovakia
-
Telomir Pharmaceuticals, Inc.Not yet recruitingTriple-Negative Breast Cancer (TNBC) | Metastatic Triple-negative Breast Cancer | Advanced Triple-Negative Breast Cancer
-
Peregrine PharmaceuticalsWithdrawnBreast Cancer | Triple Negative Breast Cancer | Triple Negative Breast Neoplasms | Triple-Negative Breast Cancer | Triple-Negative Breast Neoplasm | ER-Negative PR-Negative HER2-Negative Breast Neoplasms | ER-Negative PR-Negative HER2-Negative Breast Cancer
-
Rima PatelRecruitingTNBC - Triple-Negative Breast Cancer | Locally Advanced Triple Negative Breast CancerUnited States
-
Washington University School of MedicineNational Cancer Institute (NCI); National Institutes of Health (NIH); MedImmune...TerminatedTriple Negative Breast Cancer | Triple Negative Breast Neoplasms | TNBC - Triple-Negative Breast Cancer | Triple-negative Breast CarcinomaUnited States
-
Swiss Cancer InstituteRecruitingTriple-negative Breast Cancer | TNBC - Triple-Negative Breast CancerSwitzerland
-
AkesoActive, not recruitingMetastatic Triple-negative Breast Cancer | Locally Advanced Triple-negative Breast CancerChina
-
Mabwell (Shanghai) Bioscience Co., Ltd.RecruitingTriple-Negative Breast CancerChina
-
Fudan UniversityRecruitingTriple-negative Breast CancerChina
-
UNICANCERGustave Roussy, Cancer Campus, Grand Paris; SOLTI Breast Cancer Research Group and other collaboratorsRecruitingTriple-negative Breast CancerFrance, Spain
Clinical Trials on Sacituzumab Govitecan-hziy
-
Peking University Cancer Hospital & InstituteRecruitingBreast Cancer | Brain Metastases From Breast Cancer | Trop2China
-
Memorial Sloan Kettering Cancer CenterGilead SciencesRecruitingMesothelioma | Mesotheliomas Pleural | Mesothelioma; PleuraUnited States
-
Georgetown UniversityGilead SciencesRecruitingThymic Carcinoma | ThymomaUnited States
-
Gilead SciencesRecruitingLiver Failure | Advanced or Metastatic Solid TumorFrance, Spain, United States
-
Gilead SciencesParexel; IQVIA RDS (Shanghai) Co., Ltd.; Medidata Solutions; Q Squared Solutions...Active, not recruitingMetastatic Triple-negative Breast CancerChina
-
Gilead SciencesActive, not recruiting
-
Veru Inc.WithdrawnMetastatic Triple Negative Breast Cancer
-
Gilead SciencesRecruitingTriple Negative Breast CancerUnited States, Australia, South Korea
-
Gilead SciencesActive, not recruitingMetastatic Solid TumorUnited States, Spain, France, Hong Kong, Australia, Belgium, Taiwan, Canada
-
West China HospitalRecruitingResectable Head and Neck Squamous Cell CarcinomaChina