A Study to Learn How Well the Study Treatment Asundexian Works and How Safe it is Compared to Apixaban to Prevent Stroke or Systemic Embolism in People With Irregular and Often Rapid Heartbeat (Atrial Fibrillation), and at Risk for Stroke (OCEANIC-AF)

February 26, 2024 updated by: Bayer

A Multicenter, International, Randomized, Active Comparator-controlled, Double-blind, Double-dummy, Parallel-group, 2-arm, Phase 3 Study to Compare the Efficacy and Safety of the Oral FXIa Inhibitor Asundexian (BAY 2433334) With Apixaban for the Prevention of Stroke or Systemic Embolism in Male and Female Participants Aged 18 Years and Older With Atrial Fibrillation at Risk for Stroke

Researchers are looking for a better way to treat people with atrial fibrillation and prevent stroke or systemic embolism (blood clots travelling through the blood stream to plug another vessel).

Atrial fibrillation is a condition of having irregular and often rapid heartbeat. It can lead to the formation of blood clots in the heart which can travel through the blood stream to plug another vessel, and like this lead to serious and life-threatening conditions, such as a stroke. A stroke occurs because the brain tissue beyond the blockage no longer receives nutrients and oxygen so that brain cells die. As strokes arising from atrial fibrillation can involve extensive areas of the brain, it is important to prevent them.

Blood clots are formed in a process known as coagulation. Medications are already available to prevent the formation of blood clots. When taken by mouth (orally), they are known as oral anticoagulants (OACs) including apixaban. OACs decrease the risk of the above-mentioned serious and life-threatening conditions. The main side effect of OACs is an increase of the risk of bleeding.

The study treatment asundexian is a new type of anticoagulant currently under development to provide further treatment options. Asundexian aims to further improve the standard of care with regard to the risk of bleeding.

The main purpose of this study is to collect more data about how well asundexian works to prevent stroke and systemic embolism and how safe it is compared to apixaban in people with atrial fibrillation and at high risk for stroke.

To see how well the study treatment asundexian works researchers compare:

how long asundexian works well and
how long apixaban works well after the start of the treatment. Working well means that the treatments can prevent the following from happening:
stroke and/or
systemic embolism. The study will keep collecting data until a certain number of strokes or embolisms happen in the study.

To see how safe asundexian is, the researchers will compare how often major bleedings occur after taking the study treatments asundexian and apixaban, respectively. Major bleedings are bleedings that have a serious or even life-threatening impact on a person's health.

The study participants will be randomly (by chance) assigned to 1 of 2 treatment groups, A and B. Dependent on the treatment group, the participants will either take the study treatment asundexian by mouth once a day or apixaban by mouth twice a day for approximately 9 - 33 months.

Each participant will be in the study for approximately 9 - 34 months. There will be visits to the study site every 3 to 6 months and up to 7 phone calls. Those participants who do not want or are unable to have visits to the study site may join the study remotely in selected locations. The location name contains the abbreviation - DCT in such cases.

During the study, the study team will:

take blood samples
do physical examinations
examine heart health using an electrocardiogram (ECG)
check vital signs such as blood pressure and heart rate
do pregnancy tests
ask the participants questions about their quality of life
ask the participants questions about how they are feeling and what adverse events they are having.

An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments.

Study Overview

Status

Terminated

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

14830

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Argentina
- - Corrientes, Argentina, 3400
    - Inst. de Cardiología de Corrientes Juana Francisca Cabral
  - Santa Fe, Argentina, S3000FWO
    - Centro de Investigaciones Clinicas del Litoral
- Buenos Aires
  - Bahía Blanca, Buenos Aires, Argentina, 8000
    - Instituto de Investigaciones Clinicas Bahia Blanca
  - General Arenales, Buenos Aires, Argentina, C1061AAS
    - Centro de Investigación y Prevención Cardiovascular
  - La Plata, Buenos Aires, Argentina, B1900
    - Hospital Italiano de La Plata | Clinical Research Department
  - Lanus, Buenos Aires, Argentina, B1824
    - Centro de Investigaciones Medicas Lanus | Research Department
  - Mar del Plata, Buenos Aires, Argentina, B7600FZ0
    - Instituto de Investigaciones Clinicas
  - San Isidro, Buenos Aires, Argentina, B1642DCD
    - CardioAlem Investigaciones Monitoreos San Isidro SRL
  - San Nicolás, Buenos Aires, Argentina, B2900DMH
    - Instituto de Investigaciones Clinicas San Nicolás
  - Temperley, Buenos Aires, Argentina
    - Centro de Investigaciones Medicas Temperley
  - Zárate, Buenos Aires, Argentina, B2800DGH
    - Instituto de Investigaciones Clinicas Zarate
- Ciudad Auton. De Buenos Aires
  - Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina, C1056ABJ
    - Centro de Investigaciones Metabólicas
  - Caba, Ciudad Auton. De Buenos Aires, Argentina, C1018DES
    - Centro de Investigaciones Clínicas
  - Villa Luro, Ciudad Auton. De Buenos Aires, Argentina, C1440CFD
    - Centro de Especialidades Médicas
- Santa Fe
  - Rosario, Santa Fe, Argentina, S2000DEJ
    - Instituto Médico de la Fundación Estudios Clínicos
  - Rosario, Santa Fe, Argentina, S2000DTB
    - Laboratorio de Hemostasia y Trombosis
- Tucuman
  - San Miguel de Tucumán, Tucuman, Argentina, T4000ICL
    - Investigaciones Clinicas Tucuman | San Miguel de Tucuman, Argentina
Australia
- - Kingswood, Australia, 2747
    - Nepean Hospital
- Australian Capital Territory
  - Garran, Australian Capital Territory, Australia, 2605
    - The Canberra Hospital
- New South Wales
  - Blacktownn, New South Wales, Australia, 2148
    - Blacktown Hospital
  - Concord, New South Wales, Australia, 2139
    - Concord Repatriation General Hospital
  - Liverpool, New South Wales, Australia, 2170
    - South Western Sydney Local Health District | Liverpool Hospital - Stroke and Neurovascular Department
  - New Lambton, New South Wales, Australia, 2305
    - John Hunter Hospital
  - Wollongong, New South Wales, Australia, 2500
    - Illawarra Shoalhaven Local Health District
- Queensland
  - Auchenflower, Queensland, Australia, 4066
    - Advara HealthCare Wesley
  - Birtinya, Queensland, Australia, 4575
    - Sunshine Coast University Hospital
  - Brisbane, Queensland, Australia, 4029
    - Royal Brisbane & Women's Hospital
  - Herston, Queensland, Australia, 4029
    - The Prince Charles Hospital
  - Milton, Queensland, Australia, 4064
    - Core Research Group Pty Ltd | Brisbane, Australia
  - Redcliffe, Queensland, Australia, 4020
    - Redcliffe District Hospital
  - Southport, Queensland, Australia, 4215
    - Gold Coast University Hospital
- South Australia
  - Adelaide, South Australia, Australia, 5000
    - Royal Adelaide Hospital
  - Adelaide, South Australia, Australia, 5042
    - Flinders Medical Centre
  - Adelaide, South Australia, Australia, 5000
    - Nightingale Research
  - Leabrook, South Australia, Australia, 5068
    - Advara HealthCare Leabrook
  - Woodville South, South Australia, Australia, 5011
    - Queen Elizabeth Hospital AUS
- Victoria
  - Ballarat, Victoria, Australia, 3350
    - Grampians Health Ballarat
  - Box Hill, Victoria, Australia, 3128
    - Eastern Health
  - Geelong, Victoria, Australia, 3220
    - Barwon Health
  - Hoppers Crossing, Victoria, Australia, 3029
    - Baker Heart and Diabetes Institute
  - Malvern, Victoria, Australia, 3144
    - Cabrini Malvern
  - Parkville, Victoria, Australia, 3050
    - Royal Melbourne Hospital
  - Prahran, Victoria, Australia, 3181
    - The Alfred Hospital
  - St Kilda East, Victoria, Australia, 3183
    - The Avenue Cardiovascular Centre
- Western Australia
  - Murdoch, Western Australia, Australia, 6961
    - Fiona Stanley Hospital
  - Perth, Western Australia, Australia, 6150
    - Advara HealthCare Joondalup
Austria
- - Salzburg, Austria, 5020
    - Uniklinikum Salzburg|Innere Medizin II, Kardiologie
  - Wien, Austria, 1140
    - Hanusch Krankenhaus | 2. Medizinische Abteilung
  - Wien, Austria, 1190
    - Imed19-privat
- Kärnten
  - Klagenfurt, Kärnten, Austria, 9020
    - Klinikum Klagenfurt | Innere Medizin und Kardiologie
- Niederösterreich
  - Mistelbach, Niederösterreich, Austria, 2130
    - Landesklinikum Mistelbach|Kardiologie u. Internistische Med
  - St. Poelten, Niederösterreich, Austria, 3100
    - UK St. Poelten | Innere Med III
- Oberösterreich
  - Braunau, Oberösterreich, Austria, 5280
    - Krankenhaus St. Josef Braunau | Innere Medizin I
  - Linz, Oberösterreich, Austria, 4020
    - Elisabethinen Linz | Kardiologie, Angiologie & Intensiv Med
  - Linz, Oberösterreich, Austria, 4021
    - Kepler UK Linz | Kardiologie & Intensivmedizin Campus III
  - Wels, Oberösterreich, Austria, 4600
    - Klinikum Wels-Grieskirchen | Innere Medizin II
- Steiermark
  - Graz, Steiermark, Austria, 8036
    - MedUni Graz | Kardiologie
- Tirol
  - Hall in Tirol, Tirol, Austria, 6060
    - Landeskrankenhaus Hall | Abteilung fuer Innere Medizin
  - Innsbruck, Tirol, Austria, 6020
    - MedUni Innsbruck | Kardiologie und Angiologie
- Vorarlberg
  - Feldkirch, Vorarlberg, Austria, 6800
    - LKH Feldkirch | Innere Medizin I mit Kardiologie
- Wien
  - Vienna, Wien, Austria, 1090
    - MedUni Wien | Innere Medizin II, Kardiologie
  - Vienna, Wien, Austria, 1210
    - Klinik Floridsdorf | Herz-, Gefaess- u. Kardio Ambulaz
Belgium
- - Aalst, Belgium, 9300
    - Algemeen Stedelijk Ziekenhuis Campus Aalst
  - Aalst, Belgium, 9300
    - OL Vrouwziekenhuis - Campus Aalst
  - Antwerp, Belgium, 2020
    - ZNA Middelheim
  - Brasschaat, Belgium, 2930
    - Algemeen Ziekenhuis Klina | Cardiology Department
  - Brugge, Belgium, 8000
    - AZ Sint-Jan Brugge-Oostende | Sint-Jan - Cardiology
  - Bruxelles - Brussel, Belgium, 1200
    - CU Saint-Luc/UZ St-Luc
  - Dendermonde, Belgium, 9200
    - AZ Sint Blasius, Cardiology, Dendermonde
  - Genk, Belgium, 3600
    - Ziekenhuis Oost-Limburg | Genk, Sint-Jan campus - Cardiology Department
  - Gilly, Belgium, 6060
    - Grand Hopital de Charleroi
  - Hasselt, Belgium, 3500
    - Jessa Ziekenhuis
  - Liege, Belgium, 4000
    - CHR de la Citadelle - Cardiology
  - Liège, Belgium, 4000
    - CHC MontLégia Neurology Department
  - Mechelen, Belgium, 2800
    - AZ Sint-Maarten
  - Roeselare, Belgium, 8800
    - AZ Delta / Cardiology
  - Sint-Niklaas, Belgium, 9100
    - Vitaz Sint-Niklaas Moerland
- Antwerpen
  - Bonheiden, Antwerpen, Belgium, 2820
    - Imeldaziekenhuis - St-Elisabethkliniek / Cardiology
  - Edegem, Antwerpen, Belgium, 2650
    - UZ Antwerpen - Cardiology
  - Wilrijk, Antwerpen, Belgium, 2610
    - GZA Ziekenhuizen | Saint Augustine Campus - Cardiology Department
- Namur
  - Yvoir, Namur, Belgium, 5530
    - University Hospital Louvain Namur | Godinne - Cardiology Department
- Oost-Vlaanderen
  - Gent, Oost-Vlaanderen, Belgium, 9000
    - AZ St-Lucas Campus St-Lucas - Cardiology
  - Gent, Oost-Vlaanderen, Belgium, 9000
    - Maria Middelares General Hospital | Cardiology Department
- Vlaams Brabant
  - Leuven, Vlaams Brabant, Belgium, 3000
    - UZ Leuven Gasthuisberg
- West-Vlaanderen
  - Kortrijk, West-Vlaanderen, Belgium, 8500
    - AZ Groeninge Campus Kennedylaan - Cardiology
Brazil
- - Minas Gerais, Brazil, 38400-368
    - Eurolatino Pesquisas Médicas Ltda.
  - Rio de Janeiro, Brazil, 22.0080-040
    - Hospital São Lucas - Rio de Janeiro
  - Sao Paulo, Brazil, 01321-001
    - Hospital Alemão Oswaldo Cruz
- Bahia
  - Salvador, Bahia, Brazil, 40170-130
    - Instituto Cardio Pulmonar da Bahia
- Goiás
  - Goiânia, Goiás, Brazil, 74605-020
    - Hospital das Clínicas de Goiânia
- Minas Gerais
  - Belo Horizonte, Minas Gerais, Brazil, 30150-240
    - Cardresearch Cardilogia Assistencial e de Pesquisas LTDA
  - Poços de Caldas, Minas Gerais, Brazil, 37706-106
    - Hospital Maternidade e Pronto Socorro Santa Lúcia
- Parana
  - Curitiba, Parana, Brazil, 80045-170
    - Quanta Diagnosticos e Terapia
  - Curitiba, Parana, Brazil, 80730-150
    - Hospital Universitario Evangelico De Curitiba
  - Curitiba, Parana, Brazil, 80810-050
    - Centro de Pesquisa de São Francisco
  - Paraná, Parana, Brazil, 83430-000
    - Núcleo de Pesquisa Clínica do Hospital Angelina Caron
- Rio Grande Do Sul
  - Porto Alegre, Rio Grande Do Sul, Brazil, 91350-200
    - Hospital Nossa Senhora da Conceicao
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90035-903
    - Hospital de Clinicas de Porto Alegre
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90020-090
    - Irmandade Santa Casa de Misericordia de Porto Alegre
- Santa Catarina
  - Blumenau, Santa Catarina, Brazil, 89010-500
    - Clínica Procardio Ltda
- Sao Paulo
  - Botucatu, Sao Paulo, Brazil, 18618-970
    - UPECLIN - Unidade de Pesquisa Clínica de Botucatu
  - Campinas, Sao Paulo, Brazil, 13060-080
    - Inst. Pesq. Clínica de Campinas - Saraiva & Berlinger
  - Marília, Sao Paulo, Brazil, 17515-000
    - ICM - Instituto do Coração de Marília
  - Santo André, Sao Paulo, Brazil, 09030-010
    - Hospital e Maternidade Dr Christóvão da Gama
  - São José do Rio Preto, Sao Paulo, Brazil, 15090-000
    - Hospital de Base | Integrated Research Center
  - São Paulo, Sao Paulo, Brazil, 01317-002
    - Hospital Samaritano Paulista
  - São Paulo, Sao Paulo, Brazil, 01221-020
    - Irmandade da Santa Casa de Misericordia - Sao Paulo
  - São Paulo, Sao Paulo, Brazil, 04012-180
    - Instituto Dante Pazzanese de Cardiologia
  - São Paulo, Sao Paulo, Brazil, 13034-685
    - PUC Campinas
- Sergipe
  - Aracaju, Sergipe, Brazil, 49055-530
    - Clínica do Coração
Bulgaria
- - Blagoevgrad, Bulgaria, 2700
    - Multiprofile Hospital for Active Treatment Puls | Clinical Trial Center
  - Burgas, Bulgaria, 8000
    - MHAT '' Heart and Brain'' Burgas
  - Kardzhali, Bulgaria, 6600
    - MC Avitsena EOOD
  - Pernik, Bulgaria, 2300
    - ¿ultidisc. hosp. for act. treatm. Sveti Georgi - Pernik OOD
  - Plovdiv, Bulgaria, 4000
    - Medical centre Hipokrat - N EOOD
  - Plovdiv, Bulgaria, 4000
    - Multiprofile Hospital for Active Treatment Medline Clinic
  - Plovdiv, Bulgaria, 4004
    - Multiprofile Hospital for Active Treatment Sveta Karidad | Cardiology Department
  - Ruse, Bulgaria, 7000
    - Medical Center Rusemed
  - Shumen, Bulgaria, 9700
    - MHAT Shumen AD
  - Silistra, Bulgaria, 7500
    - Multiprofile Hospital for Active Treatment - Silistra
  - Sofia, Bulgaria, 1142
    - Medical Center Cardiohelp
  - Sofia, Bulgaria, 1202
    - Second Medical Center Sofia EOOD
  - Sofia, Bulgaria, 1606
    - Umhatem N. I. Pirogov EAD / Cardiology
  - Sofia, Bulgaria, 1618
    - Multiprofile Hospital for Active Treatment Sveta Sofia
  - Sofia, Bulgaria, 1233
    - Multiprofile Hospital for Active Treatment Knyaginya Klementina Sofia EAD | Cardiology Department
  - Sofia, Bulgaria, 1202
    - FutureMeds | Diagnostic Consultative Center Ascendent
  - Sofia, Bulgaria, 1527
    - University Hospital for Active Treatment Tsaritsa Joanna - ISUL | Cardiology Clinic
  - Sofia, Bulgaria, 1618
    - Diagnostic-Consultative Center XX | Cardiology Department
  - Sofia, Bulgaria, 1309
    - Multiprofile Hospital for Active Treatment National Cardiology Hospital | Cardiology Department
  - Stara Zagora, Bulgaria, 6000
    - Multiprofile Hospital for Active Treatment Trakiya Park | Cardiology Department
  - Stara Zagora, Bulgaria, 6010
    - Medical Center Zara-Med EOOD | Cardiology Department
  - Varna, Bulgaria, 9020
    - NOVA Clinic Medical Center | Varna, BG
  - Veliko Tarnovo, Bulgaria, 5000
    - MHAT Dr Stefan Cherkezov
Canada
- - Quebec, Canada, G1R 2J6
    - CHU de Quebec-Universite Laval
- Alberta
  - Edmonton, Alberta, Canada, T6G 2B7
    - University of Alberta Hospital
  - Edmonton, Alberta, Canada, T5H 4B9
    - Edmonton Cardiology Consultants
- British Columbia
  - Kamloops,, British Columbia, Canada, V2C 2T1
    - Interior Health - Royal Inland Hospital
  - New Westminster, British Columbia, Canada, V3L 3W4
    - Fraser Clinical Trials, Inc.
  - Vancouver, British Columbia, Canada, V5Z 1M9
    - Vancouver General Hospital
  - Victoria, British Columbia, Canada, V8R 1B2
    - Victoria Heart Institute Foundation
- New Brunswick
  - Moncton, New Brunswick, Canada, E1G 1A7
    - G.A. Research Associates, Ltd.
- Newfoundland and Labrador
  - St. John's, Newfoundland and Labrador, Canada, A1B3V6
    - Memorial University of Newfoundland
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 3A7
    - QEII Health Sciences Centre
- Ontario
  - Cambridge, Ontario, Canada, N1R 6V6
    - Cambridge Cardiac Care Center
  - Hamilton, Ontario, Canada, L8L 2X2
    - Hamilton Health Sciences
  - Hamilton, Ontario, Canada, L8M 1K7
    - Hamilton Medical Research Group
  - Hamilton, Ontario, Canada, L8M 1K7
    - Hamilton Med.Research Group - DCT
  - Hamilton, Ontario, Canada, L8L 2X2
    - McMaster University Medical Centre
  - London, Ontario, Canada, N5W 6A2
    - Milestone Research
  - London, Ontario, Canada, N6A5A5
    - London Health Sciences Centre | University Hospital - London Heart Rhythm Program - Cardiology
  - Oakville, Ontario, Canada, L6K 3W7
    - Oakville Cardiovascular Research
  - Oshawa, Ontario, Canada, L1J2K1
    - Dr. James Cha
  - Peterborough, Ontario, Canada, K9J 0B2
    - Kawartha Cardiology Clinical Trials
  - Scarborough, Ontario, Canada, M1B 4Z8
    - Heart Health Institute
  - St. Catharines, Ontario, Canada, L2S 0A9
    - Niagara Health - St. Catharines Site
  - Toronto, Ontario, Canada, M4N 3M5
    - Sunnybrook Health Sciences Centre
  - Toronto, Ontario, Canada, M5B 1W8
    - Unity Health Toronto: St. Michael's Hospital
  - Toronto, Ontario, Canada, M5G 2C4
    - Toronto General Hospital UHN
  - Toronto, Ontario, Canada, M5S 1B2
    - Women's College Hospital | WCH Main Site - Women's College Research Institute - Cardiology Department
  - York, Ontario, Canada, M9N 1W4
    - Dr. Louis Yao
- Quebec
  - Brossard, Quebec, Canada, J4Z 2K9
    - ViaCar Recherches Cliniques Inc.
  - Chicoutimi, Quebec, Canada, G7H 5H6
    - CIUSSS Saguenay Lac-St-Jean
  - Laval, Quebec, Canada, H7M 3L9
    - Centre intégré de santé et de services sociaux de Laval, Hôp
  - Mirabel, Quebec, Canada, J7J 2K8
    - Centricity Research Mirabel Multispecialty
  - Montreal, Quebec, Canada, H4A 3J1
    - McGill University Health Centre - Glen Site
  - Montreal, Quebec, Canada, H2X 0C1
    - CHUM - Centre Hospitalier de L'Universite de Montreal
  - Montreal, Quebec, Canada, H4J 1C5
    - CIUSSS NÎM Hôpital Sacré-Coeur
  - Montréal,, Quebec, Canada, H1T 1C8
    - Montreal Heart Institute
  - Québec, Quebec, Canada, G1V 4G5
    - Institut universitaire de cardiologie et de pneumologie de Q
  - Sherbrooke, Quebec, Canada, J1H 5N4
    - CIUSSS de l'Estrie-CHUS, Hopital Fleurimont
  - Terrebonne, Quebec, Canada, J6V 2H2
    - CISSSL - Hôpital Pierre-Le Gardeur
  - Trois-Rivieres, Quebec, Canada, G9A 4P3
    - Diex Research Trois-Rivières Inc.
China
- - Beijing, China, 100029
    - Beijing Anzhen Hospital, Capital Medical University
  - Beijing, China, 100730
    - Peking Union Medical College Hospital CAMS
  - Beijing, China, 100034
    - Peking University First Hospital
  - Beijing, China, 100029
    - China-Japan Friendship Hospital
  - Beijing, China, 100020
    - Beijing Chaoyang Hospital, Capital Medical University
  - Beijing, China, 100053
    - Xuanwu Hospital Capital Medical University
  - Beijing, China, 100730
    - Beijing Tongren Hospital, Capital Medical University (West)
  - Beijing, China, 102218
    - Beijing Tsinghua Changgung Hospital
  - Shanghai, China, 200032
    - Zhongshan Hospital, Fudan University
  - Shanghai, China, 200040
    - Huashan Hospital, Fudan University
  - Shanghai, China, 200080
    - Shanghai General Hospital
  - Shanghai, China, 200333
    - Shanghai Putuo District Central Hospital
  - Tianjin, China, 300000
    - Tianjin People's Hospital
  - Tianjin, China, 300457
    - TEDA International Cardiovascular Hospital
- Fujian
  - Fuzhou, Fujian, China
    - The 1st Affiliated Hospital Fujian Medical University
  - Xiamen, Fujian, China, 361006
    - Xiamen Cardiovascular Hospital Xiamen University
- Gansu
  - Lanzhou, Gansu, China, 730030
    - Lanzhou University Second Hospital
- Guangdong
  - Guangzhou, Guangdong, China, 510405
    - The First Affiliated Hospital of Guangzhou University of TCM
  - Guangzhou, Guangdong, China, 510630
    - The First Affiliated Hospital of Jinan University
  - Guangzhou, Guangdong, China, 510100
    - Guangdong Provincial People's Hospital
  - Guangzhou, Guangdong, China, 511400
    - Guangzhou Panyu Central Hospital
  - Guangzhou, Guangdong, China
    - The 2nd Affiliated Hospital of Guangzhou Medical University
  - Guangzhou, Guangdong, China, 510180
    - Guangzhou First People Hospital
  - Huizhou, Guangdong, China, 516001
    - Huizhou Central People's Hospital
- Guangxi
  - Liuzhou, Guangxi, China, 545005
    - Liuzhou Worker's Hospital
- Hainan
  - Haikou, Hainan, China, 570311
    - Hainan Provincial People's Hospital
  - Sanya, Hainan, China, 572000
    - Hainan Third People's Hospital (Province Nongken Sanya Hopt)
- Hebei
  - Cangzhou, Hebei, China, 061000
    - Cangzhou Central Hospital
  - Shijiazhuang, Hebei, China, 050000
    - The First Hospital of Hebei Medical Univesity
  - Zhangjiakou, Hebei, China, 075000
    - The First Affiliated Hospital of Hebei North University
- Heilongjiang
  - Daqing, Heilongjiang, China, 163311
    - Daqing Oilfield General Hospital
  - Harbin, Heilongjiang, China, 150001
    - The First Affiliated Hospital Of Harbin Medical University
  - Harbin, Heilongjiang, China, 150001
    - The 4th Affiliated Hospital of Harbin Medical University
- Henan
  - Luoyang, Henan, China, 471000
    - 1st Affiliated Hospital of Henan Science and Technology Univ
  - Luoyang, Henan, China, 471002
    - Luoyang Third People's Hospital
  - Xinxiang, Henan, China, 453000
    - Xinxiang Central Hospital
- Hubei
  - Wudan, Hubei, China, 430022
    - Union Hospt Tongji Medical Colleg. Huazhong univ. Scien&Tech
  - Wuhan, Hubei, China, 430060
    - Renmin Hospital of Wuhan University
  - Wuhan, Hubei, China, 430014
    - The Central Hospital of Wuhan, Tongji Medl Collg Huazhong...
  - Wuhan, Hubei, China, 430034
    - Wuhan No. 4 Hospital
- Hunan
  - Changsha, Hunan, China, 410013
    - The Third Xiangya Hospital of Central South University
  - Changsha, Hunan, China, 410011
    - The Third Hospital of Changsha
- Inner Mongolia
  - Baotou, Inner Mongolia, China, 014010
    - The First Affiliated Hospital of Baotou Medical College
  - Baotou, Inner Mongolia, China, 014040
    - Baotou Central Hospital
  - Hohhot, Inner Mongolia, China, 010017
    - Inner Mongolia People's Hospital
- Jiangsu
  - Huai'An, Jiangsu, China, 223300
    - Huai'an First People's Hospital, Nanjing Medical University
  - JiangSu, Jiangsu, China, 212001
    - Affiliated Hospital of Jiangsu University
  - Nanjing, Jiangsu, China, 210006
    - Nanjing First Hospital
  - Nanjing, Jiangsu, China, 210009
    - Zhongda Hospital Southeast University
  - Nanjing, Jiangsu, China, 210000
    - The Second Affiliated Hospital of Nanjing Medical University
  - Nanjing, Jiangsu, China, 211103
    - Nanjing Jiangning Hospital
  - Taizhou, Jiangsu, China, 225317
    - Taizhou People's Hospital
  - Yangzhou, Jiangsu, China, 225001
    - Northern Jiangsu People's Hospital
  - Yangzhou, Jiangsu, China, 225012
    - Yangzhou No. 1 People's Hospital (West Hospital)
- Jiangxi
  - Nanchang, Jiangxi, China, 330006
    - The First Affiliated Hospital of Nanchang University
  - Nanchang, Jiangxi, China, 330006
    - Jiangxi Provincial People's Hospital
  - Nanchang, Jiangxi, China, 330009
    - The Third Hospital of Nanchang
  - Pingxiang, Jiangxi, China, 337055
    - Pingxiang People's Hospital
- Jilin
  - Changchun, Jilin, China, 130031
    - China-Japan Union Hospital of Jilin University
  - Tonghua, Jilin, China, 134001
    - Tonghua Central Hospital
- Liaoning
  - Jinzhou, Liaoning, China, 121001
    - The First Affiliated Hospital of Jinzhou Medical University
  - Panjin, Liaoning, China, 124010
    - Panjin Liaohe Oilfield Gem Flower Hospital
- Ningxia
  - Yinchuan, Ningxia, China, 750004
    - General Hospital of Ningxia Medical University
  - Yinchuan, Ningxia, China, 750001
    - The First People's Hospital of Yinchuan
- Qinghai
  - Xining, Qinghai, China, 810001
    - Qinghai University Affiliated Hospital
- Shaanxi
  - Xianyang, Shaanxi, China, 716000
    - Yan'an University Xianyang Hospital
- Shandong
  - Jinan, Shandong, China, 250012
    - Qilu Hospital of Shandong University
  - Jinan, Shandong, China, 250013
    - Jinan Central Hospital
  - Jinan, Shandong, China, 250033
    - The Second Hospital of Shandong University
  - Jining, Shandong, China, 272011
    - Jining No.1 People's Hospital
  - Jining, Shandong, China, 272007
    - Affiliated Hospital of Jining Medical University
  - Taian, Shandong, China, 271099
    - Taian City Central Hospital
  - Zibo, Shandong, China, 250036
    - Zibo Central Hospital
- Shanxi
  - Taiyuan, Shanxi, China, 030024
    - Shanxi Candiovascular Hospital
  - Taiyuan, Shanxi, China, 030032
    - Shanxi Bethune Hospital
  - Xi'an, Shanxi, China, 710068
    - Shaanxi Provincial People's Hospital
  - Yuncheng, Shanxi, China, 044099
    - Yuncheng Central Hospital
- Sichuan
  - Chengdu, Sichuan, China, 610072
    - SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHos
  - Chengdu, Sichuan, China, 610041
    - West China Hospital,Sichuan University
  - Chengdu, Sichuan, China, 610021
    - Chengdu Second People's Hospital
  - Deyang, Sichuan, China, 618000
    - People's Hospital of Deyang City
- Xinjiang
  - Urumchi, Xinjiang, China
    - The First Affiliated Hospital of Xinjiang Medical University
- Zhejiang
  - Hangzhou, Zhejiang, China, 310006
    - Affiliated Hangzhou First People's Hospital, Zhejiang Univ
  - Hangzhou, Zhejiang, China, 310000
    - The 1st Affiliated Hospital of Zhejiang University
  - Ningbo, Zhejiang, China, 315010
    - Ningbo First Hospital
  - Ningbo, Zhejiang, China, 31510
    - Hwa Mei Hospital, University of Chinese Academy Sciences
  - Taizhou, Zhejiang, China, 317099
    - Taizhou Hospital of Zhejiang Province
  - Wenzhou, Zhejiang, China, 325000
    - The First Affiliated Hospital of Wenzhou Medical University
Czechia
- - Brno, Czechia, 63600
    - Vojenska nemocnice Brno
  - Brno, Czechia, 625 00
    - Fakultni nemocnice Brno
  - Brno, Czechia, 612 00
    - Kardiologicka ambulance Brno s.r.o.
  - Brno, Czechia, 639 00
    - Amkardia s.r.o.
  - Bruntal, Czechia, 792 01
    - Kardiologicka ambulance Cormedico
  - Ceske Budejovice, Czechia, 370 01
    - Nemocnice Ceske Budejovice, a.s. Department of kardiologie
  - Frydek-Mistek, Czechia, 73801
    - Mrozek kardiologie
  - Hodonin, Czechia, 69501
    - MATMED s.r.o.
  - Liberec, Czechia, 460 63
    - Krajska Nemocnice Liberec
  - Olomouc, Czechia, 77900
    - Fakultni nemocnice Olomouc
  - Ostrava - Poruba, Czechia, 708 68
    - Benedor s.r.o.
  - Ostrava-Zabreh, Czechia, 700 30
    - MUDr. Michalik s.r.o.
  - Plzen, Czechia, 301 00
    - Fakultni nemocnice Plzen
  - Praha, Czechia, 160 00
    - Cevni Kulatak
  - Praha 10, Czechia, 10034
    - Fakultni nemocnice Kralovske Vinohrady
  - Praha 4, Czechia, 140 21
    - Institut klinické a experimentalni mediciny
  - Praha 5, Czechia, 150 06
    - Fakultni nemocnice v Motole
  - Praha 7, Czechia, 170 00
    - Medicon Poliklinika Holesovice
  - Slany, Czechia, 274 01
    - Nemocnice Slany
  - Zlin, Czechia, 760 01
    - Cardio Research s.r.o.
Denmark
- - Aalborg, Denmark, DK-9000
    - Region Nordjylland | Aalborg University Hospital - Cardiology Department
  - Copenhagen, Denmark, 2300
    - Capital Region | Amager Hospital - Cardiology Outpatient Clinic
  - Esbjerg, Denmark, 6700
    - Sydvestjysk Sygehus Esbjerg | Kardiologisk Forskningsenhed
  - Frederiksberg, Denmark, 2000
    - Capital Region | Frederiksberg Hospital - Department of Cardiology Research
  - Hellerup, Denmark, 2900
    - Capital Region | Gentofte Hospital - Cardiology Research
  - Herlev, Denmark, 2730
    - Capital Region | Herlev Hospital - Department of Heart Disease
  - Herning, Denmark, 7400
    - Region Midtjylland | Regionshospitalet Godstrup - Clinic for Heart Research
  - Hilleroed, Denmark, 3400
    - Nordsjaellands Hospital | Hillerod - Cardiology Department
  - Hjørring, Denmark, DK-9800
    - Region Nordjylland | Hjoerring - Cardiology Department
  - Holbæk, Denmark, 4300
    - Holbæk Sygehus
  - Hvidovre, Denmark, 2650
    - Capital Region | Hvidovre Hospital - Department of Cardiology
  - Kolding, Denmark, 6000
    - Sygehus Lillebaelt | Kolding Sygehus - Medicinske Sygdomme
  - Roskilde, Denmark, 4000
    - Sjællands universitetshospital Roskilde
  - Svendborg, Denmark, 5700
    - Odense University Hospital | Svendborg Hospital - Cardiovascular Research Unit
  - Viborg, Denmark, 8800
    - Region Midtjylland | Viborg Regional Hospital - Cardiology - Heart Research
  - Århus N, Denmark, 8200
    - Region Midtjylland | Aarhus University Hospital - Heart Diseases - Clinical Research
Estonia
- - Tallinn, Estonia, 10138
    - East Tallinn Central Hospital
  - Tallinn, Estonia, 10138
    - Dr Signe Alliksoo Family Doctors Practice
  - Tallinn, Estonia, 11911
    - Pirita Family Doctors Centre
  - Tallinn, Estonia, 13419
    - North Estonia Medical Centre Foundation
  - Tallinn, Estonia, 13419
    - Office of Arvo Rosenthal
  - Tallinn, Estonia, EE-10617
    - West Tallinn Central Hospital
  - Tartu, Estonia, 50406
    - Tartu University Hospital
Finland
- - Espoo, Finland, 02740
    - HUS Jorvin sairaala
  - Jyväskylä, Finland, 40620
    - StudyCor Oy
  - Kuopio, Finland, FIN- 70029
    - Kuopion Yliopistollinen Sairaala
  - Kuopio, Finland, 70210
    - Health Step Finland Oy
  - Oulu, Finland, 90220
    - Oulun Yliopistollinen Sairaala
  - Tampere, Finland, 33520
    - TAYS Sydänsairaala
  - Turku, Finland, 20520
    - Turun Yliopistollinen Keskussairaala
France
- - Angers, France, 49933
    - Centre Hospitalier Universitaire - Angers
  - Bayonne, France, 64100
    - Centre Hospitalier Intercommunal de la Côte Basque-Bayonne
  - Bois-Guillaume, France, 76320
    - Hopital Charles Nicolle Chu Rouen
  - Brest, France, 29200
    - Hôpital La Cavale Blanche - CHU de Brest
  - Bron, France, 69500
    - Hôpital Louis Pradel - Bron
  - CAEN cedex 9, France, 14033
    - CHU de Caen - Hopital Cote de Nacre
  - Chambray-lès-Tours, France, 37170
    - Hôpital Trousseau - Tours
  - Cholet, France, 49325
    - Centre Hospitalier - Cholet
  - Creteil, France, 94010
    - Hopital Henri Mondor
  - GRENOBLE Cedex 09, France, 38043
    - CHU GRENOBLE - Hopital Michallon
  - LA ROCHE SUR YON cedex, France, 85925
    - Centre Hospitalier Départemental Vendée
  - Le Coudray, France, 28630
    - Centre Hospitalier Louis Pasteur
  - Lens, France, 62307
    - Centre Hospitalier du Docteur Schnaffer - Lens
  - Limoges Cedex, France, 87042
    - Hôpital Dupuytren
  - NANTES cedex 2, France, 44277
    - Nouvelles Cliniques Nantaises - Nantes
  - Nantes, France, 44035
    - Hôpital Guillaume et René Laennec - Nantes
  - Nice, France, 06002
    - Hôpital Pasteur - Nice
  - Nîmes, France, 30029
    - Hopital Carémeau - Nîmes
  - Paris, France, 75014
    - Institut Mutualiste Montsouris
  - Paris, France, 75651
    - Hôpital de la Pitié-Salpêtrière
  - Paris Cedex 15, France, 75908
    - HOPITAL EUROPEEN GEORGES POMPIDOU - Paris
  - Pessac, France, 33604
    - Hôpital Cardiologique - Pessac
  - Rennes, France, 35033
    - CHU Rennes, H Pontchaillou, Cardiologie
  - Saint Brieuc, France, 22000
    - Centre Hospitalier Régional - Saint Brieuc
  - Strasbourg, France, 67091
    - Hôpital Civil - Strasbourg
  - TOULOUSE cedex, France, 31059
    - Hôpital de Rangueil - Toulouse
  - Toulon, France, 83000
    - CHI Toulon - H La Seyne - Cardiologie
  - Toulouse, France, 31076
    - Clinique Pasteur - Toulouse
  - Tourcoing, France, 59280
    - Centre Hospitalier Gustave Dron - Tourcoing
  - Valenciennes, France, 59322
    - Centre Hospitalier - Valenciennes Cedex
  - Vandoeuvre-les-nancy, France, 54511
    - Centre Hospitalier Universitaire de Nancy
Germany
- - Hamburg, Germany, 20253
    - Klinische Forschung Hamburg GmbH
  - Hamburg, Germany, 20246
    - Uniklinikum Hamburg-Eppendorf|Klinik für Kardiologie
  - Hamburg, Germany, 22041
    - Cardiologicum Hamburg
- Baden-Württemberg
  - Bad Krozingen, Baden-Württemberg, Germany, 79189
    - Universitaets Herzzentrum Bad Krozingen
  - Heidelberg, Baden-Württemberg, Germany, 69120
    - Uni-Klinikum Heidelberg | Kardiologie Angiologie Pneumologie
  - Lahr, Baden-Württemberg, Germany, 77933
    - MEDICLIN Herzzentrum Lahr|Kardiologie
  - Ludwigsburg, Baden-Württemberg, Germany, 71634
    - Cardio Centrum Ludwigsburg
  - Singen, Baden-Württemberg, Germany, 78224
    - Hegau-Bodensee-Klinikum Singen|I. Medizinische Klinik
- Niedersachsen
  - Hannover, Niedersachsen, Germany, 30625
    - Medizinische Hochschule Hannover|Kardiologie und Angiologie
- Nordrhein-Westfalen
  - Aachen, Nordrhein-Westfalen, Germany, 52074
    - UniKlinikum Aachen|Kardio, Angio, Intensivmedizin
  - Dortmund, Nordrhein-Westfalen, Germany, 44137
    - St.Johannes-Hospital|Klinik fuer Innere Medizin I
  - Hagen, Nordrhein-Westfalen, Germany, 58135
    - Ev. Krankenhaus Hagen-Haspe|Kardiologie und Rhythmologie
  - Koeln, Nordrhein-Westfalen, Germany, 50733
    - St. Vinzenz-Hospital|Innere Medizin III, Kardiologie
  - Lüdenscheid, Nordrhein-Westfalen, Germany, 58515
    - Klinikum Lüdenscheid - Märkische Kliniken GmbH
  - Mönchengladbach, Nordrhein-Westfalen, Germany, 41063
    - Kliniken Maria Hilf GmbH
  - Remscheid, Nordrhein-Westfalen, Germany, 42859
    - Sana-Klinikum Remscheid|Kardio, Angio, Pneumo u. Intensivmed
  - Warendorf, Nordrhein-Westfalen, Germany, 48231
    - Josephs-Hospital|Kardiologie, Rhythmologie und Angiologie
  - Witten, Nordrhein-Westfalen, Germany, 58455
    - Forschungszentrum Ruhr KliFoCenter GmbH
- Rheinland-Pfalz
  - Mainz, Rheinland-Pfalz, Germany, 55131
    - UNIVERSITÄTSMEDIZIN der Johannes Gutenberg Universität Mainz
  - Worms, Rheinland-Pfalz, Germany, 67550
    - Klinikum Worms gGmbH|Kardiologie und Angiologie
- Saarland
  - Voelklingen, Saarland, Germany, 66333
    - Siteworks Pruefzentrum Voelklingen
- Sachsen
  - Dresden, Sachsen, Germany, 01067
    - Krankenhaus Dresden-Friedrichstadt
  - Dresden, Sachsen, Germany, 01099
    - Zentrum für klinische Prüfungen
  - Dresden, Sachsen, Germany, 01069
    - Pratia | Klinische Forschung Dresden
  - Leipzig, Sachsen, Germany, 04103
    - Uniklinik Leipzig / Kardiologie
  - Markkleeberg, Sachsen, Germany, 04416
    - Praxis Hr. Dr. med. Jens Taggeselle
  - Wermsdorf, Sachsen, Germany, 04779
    - Kardiologische Praxis Hr. Dr. A. Al-Zoebi
- Thüringen
  - Jena, Thüringen, Germany, 07747
    - Uniklinik Jena / Kardiologie
Greece
- - Alexandroupoli, Greece, 68100
    - University General Hospital of Alexandroupolis
  - Athens, Greece, 11527
    - G. GENNIMATAS General State Hospital of Athens
  - Athens, Greece, 11521
    - Naval Hospital of Athens
  - Athens, Greece, 106 76
    - Evangelismos General Hospital of Athens
  - Athens, Greece, 115 27
    - Hippokration General Hospital of Athens
  - Athens, Greece, 11526
    - Laiko General Hospital of Athens
  - Athens, Greece, 11528
    - General Hospital of Athens "ALEXANDRA"
  - Chaidari, Greece, 12462
    - University General Hospital Attikon
  - Elefsina, Greece, 19018
    - Thriassio General Hospital of Elefsina
  - Heraklion, Greece, 71110
    - University General Hospital of Heraklion
  - Ioannina, Greece, 45500
    - Ioannina University General Hospital
  - Larissa, Greece, 41110
    - University General Hospital of Larissa
  - Larissa, Greece, 41110
    - Univ. General Hospital of Larissa
  - Maroussi, Greece, 15123
    - MITERA Hospital
  - Nea Ionia / Athens, Greece, 142 33
    - Konstantopoulio General Hospital of Nea Ionia - AGIA OLGA
  - Patra, Greece, 26504
    - University General Hospital of Patra
  - Thessaloniki, Greece, 54642
    - Hippokration General Hospital of Thessaloniki
  - Thessaloniki, Greece, 546 36
    - AHEPA University General Hospital of Thessaloniki
  - Voula, Greece, 16673
    - General Hospital ASKLEPIEIO VOULAS
- Attica
  - Kifisia / Athens, Attica, Greece, 14561
    - KAT General Hospital of Athens
Hungary
- - Balatonfured, Hungary, 8230
    - Cardiomobile Egeszsegugyi Szolgaltato Kft.
  - Budapest, Hungary, 1088
    - Semmelweis University
  - Budapest, Hungary, 1145
    - Budapesti Uzsoki Utcai Kórház
  - Budapest, Hungary, 1204
    - Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet
  - Debrecen, Hungary, 4025
    - Belinus Bt.
  - Gyor, Hungary, 9024
    - Kardio Egeszseghaz - Dr Amer Sayour Egyeni Vallakozo
  - Gyula, Hungary, 5700
    - Trial Pharma Kft. Gyula
  - Kaposvar, Hungary, 7400
    - Somogy Varmegyei Kaposi Mor Oktato Korhaz
  - Komarom, Hungary, 2921
    - Komaromi Selye Janos Korhaz
  - Miskolc, Hungary, 3526
    - Borsod-Abauj-Zemplen Varmegyei Korhaz es Egyetemi Oktatokorhaz
  - Mosonmagyarovar, Hungary, 9200
    - TaNa Med Kft.
  - Nagykanizsa, Hungary, 8800
    - Kanizsai Dorottya Hospital
  - Nyiregyhaza, Hungary, 4400
    - Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft.
  - Nyiregyhaza, Hungary
    - Borbanya Praxis Bt.
  - Oroshaza, Hungary, 5900
    - Dr. Nagy Laszlo Egyeni Egeszsegugyi Vallalkozo
  - Oroshaza, Hungary, 5900
    - Oroshaza Hospital
  - Pecs, Hungary, 7624
    - Pecsi Tudomanyegyetem Klinikai Kozpont
  - Pecs, Hungary, 7623
    - Coromed Smo Kft
  - Szekesfehervar, Hungary, 8000
    - Complex Rendelo Med Zrt.
  - Szekszard, Hungary, 7100
    - Tolna Varmegyei Balassa Janos Korhaz
  - Szombathely, Hungary, 9700
    - Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz
  - Zalaegerszeg, Hungary, 8900
    - Belvárosi Egészségház Kft.
India
- - Calcutta, India, 700020
    - The Institute of Post Graduate Medical Education & Research (IPGMER) (SSKM Hospital)
  - Hyderabad, India, 500032
    - Asian Institute of Gastroenterology (AIG Hospital)
  - New Delhi, India, 110 029
    - All India Institute of Medical Sciences (AIIMS) - New Delhi
  - New Delhi, India, 110029
    - Vardhman Mahavir Medical College & Safdarjung Hospital (VMMC-SJH)
  - New Delhi, India, 110060
    - Sir Gangaram Hospital, Delhi
  - Pune, India, 411 011
    - King Edward Memorial (KEM) Hospital - Pune
  - Surat, India, 395001
    - Shri B.D. Mehta Mahavir Heart Institute
- Kerala
  - Kochi, Kerala, India, 682017
    - Lisie Hospital
- Maharashtra
  - Nashik, Maharashtra, India, 422005
    - Vijan Cardiac & Critical Care Centre
Israel
- - Afula, Israel, 1834111
    - Clalit Health Services through HaEmek Medical Center
  - Ashdod, Israel, 7747629
    - Assuta Ashdod
  - Ashkelon, Israel, 7830604
    - Barzilai Ashkelon University Medical Center | Cardiology Department
  - Beer Sheva, Israel, 8410101
    - Soroka University Medical Center
  - Beer Sheva, Israel, 8489507
    - Assuta Beer Sheva
  - Hadera, Israel, 3810101
    - Hillel Yaffe Medical Center
  - Haifa, Israel, 3109601
    - Rambam Health Corporation
  - Haifa, Israel, 3339419
    - Bnai Zion Medical Center
  - Haifa, Israel, 3436212
    - Lady Davis Carmel Medical Center
  - Holon, Israel, 5822012
    - Edith Wolfson Medical Center
  - Jerusalem, Israel, 9103102
    - Shaare Zedek Medical Center
  - Jerusalem, Israel, 9112001
    - Hadassah Hebrew University Hospital Ein Kerem
  - Kfar Saba, Israel, 4428164
    - Meir Medical Center
  - Lower Galilee, Israel, 15208
    - Poriya Medical Center | Cardiology Department
  - Nahariya, Israel, 22100
    - Health Corporation of Galilee Medical Center
  - Petach Tikva, Israel, 4941492
    - Clalit Health Services Rabin Medical Center-Beilinson Campus
  - Petah Tikva, Israel, 4941492
    - Clalit Health Services Rabin Medical Center-Beilinson Campus
  - Ramat Gan, Israel, 52621
    - Chaim Sheba Medical Center
  - Rehovot, Israel, 7610001
    - Kaplan Medical Center
  - Tel Aviv, Israel, 6423906
    - Tel-Aviv Sourasky Medical Center
  - Zefat, Israel, 1311001
    - Health Corporation of the Ziv Medical Center (R.A.)
  - Zrifin, Israel, 7030000
    - Shamir Medical Center (Assaf Harofeh)
Italy
- Abruzzo
  - Chieti, Abruzzo, Italy, 66100
    - ASL2 Lanciano-Vasto-Chieti
- Campania
  - Caserta, Campania, Italy, 81100
    - A.O Sant'Anna-San Sebastiano
  - Napoli, Campania, Italy, 80131
    - A.O.U. Policlinico Federico II Napoli
  - Napoli, Campania, Italy, 80131
    - A.O.R.N. Ospedali dei Colli (Monaldi-Cotugno-CTO)
- Emilia-Romagna
  - Bologna, Emilia-Romagna, Italy, 40133
    - AUSL di Bologna
  - Ferrara, Emilia-Romagna, Italy, 44124
    - A.O.U. di Ferrara
  - Modena, Emilia-Romagna, Italy, 41124
    - A.O.U. di Modena - Policlinico
  - Parma, Emilia-Romagna, Italy, 43126
    - A.O.U. di Parma
- Lazio
  - Roma, Lazio, Italy, 00157
    - Asl Roma 2
  - Roma, Lazio, Italy, 00161
    - A.O.U. Policlinico Umberto I
- Lombardia
  - Bergamo, Lombardia, Italy, 24127
    - ASST Papa Giovanni XXIII
  - Brescia, Lombardia, Italy, 25085
    - ASST del Garda
  - Milano, Lombardia, Italy, 20089
    - Istituto Clinico Humanitas - Humanitas Mirasole S.p.A.
  - Milano, Lombardia, Italy, 20138
    - IRCCS Centro Cardiologico Monzino S.p.A
  - Varese, Lombardia, Italy, 21049
    - ASST Sette Laghi
- Marche
  - Ancona, Marche, Italy, 60126
    - A.O.U. Ospedali Riuniti "Umberto I - G.M.Lancisi - G.Salesi"
  - Ascoli Piceno, Marche, Italy, 63074
    - ASUR Marche - Area Vasta 5
- Piemonte
  - Novara, Piemonte, Italy, 28100
    - A.O.U. Maggiore della Carità
- Puglia
  - Bari, Puglia, Italy, 70021
    - Ente Ecclesiastico Ospedale Generale Regionale Miulli
  - Foggia, Puglia, Italy, 71122
    - A.O.U. Ospedali Riuniti Foggia
- Toscana
  - Arezzo, Toscana, Italy, 52044
    - AUSL Toscana Sud-Est
  - Firenze, Toscana, Italy, 50134
    - A.O.U. Careggi
  - Pisa, Toscana, Italy, 56124
    - A.O.U. Pisana
- Umbria
  - Perugia, Umbria, Italy, 06129
    - A.O. di Perugia
- Veneto
  - Padova, Veneto, Italy, 35128
    - A.O.U. di Padova
  - Treviso, Veneto, Italy, 31015
    - ULSS2 Marca Trevigiana
  - Venezia, Veneto, Italy, 30174
    - ULSS3 Serenissima
Japan
- - Fukui, Japan, 910-8526
    - Fukui Prefectural Hospital
  - Fukui, Japan, 910-0067
    - Fukui General Clinic
  - Fukuoka, Japan, 814-0180
    - Fukuoka University Hospital
  - Fukuoka, Japan, 814-8522
    - Fukuoka University Nishijin Hospital
  - Fukuoka, Japan, 815-8588
    - Kyushu Central Hospital
  - Fukuoka, Japan, 811-0213
    - Social Medical Corporation the Chiyukai foundation Fukuoka Wajiro Hospital
  - Gifu, Japan, 500-8384
    - Gifu Heart Center
  - Hiroshima, Japan, 730-8518
    - Hiroshima City Hiroshima Citizens Hospital
  - Kagoshima, Japan, 892-0822
    - Tenyoukai Central Clinic
  - Kagoshima, Japan, 892-0853
    - Kagoshima Medical Center
  - Kochi, Japan, 780-8522
    - Chikamori Hospital
  - Kumamoto, Japan, 860-8518
    - Kumamoto Kinoh Hospital
  - Kyoto, Japan, 607-8062
    - Rakuwakai Otowa Hospital
  - Kyoto, Japan, 612-8555
    - National Hospital Organization Kyoto Medical Center
  - Miyazaki, Japan, 880-2102
    - Miyazaki Medical Association Hospital
  - Oita, Japan, 870-8511
    - Oita Prefectural Hospital
  - Okayama, Japan, 702-8055
    - Okayama Rosai Hospital
  - Okayama, Japan, 700-0804
    - The Sakakibara Heart Institute of Okayama
  - Okayama, Japan, 700-8557
    - Okayama City General Medical Center Okayama City Hospital
  - Osaka, Japan, 550-0006
    - Nippon Life Hospital
  - Osaka, Japan, 530-0001
    - Sakurabashi Watanabe Hospital
  - Osaka, Japan, 530-0012
    - Osaka Saiseikai Nakatsu Hospital
  - Osaka, Japan, 538-0044
    - Kitada Clinic
  - Osaka, Japan, 543-0035
    - Osaka Police Hospital
  - Osaka, Japan, 553-0003
    - Japan Community Health care Organization Osaka Hospital
  - Saga, Japan, 849-0917
    - Saga Memorial Hospital
  - Saitama, Japan, 331-8577
    - Sainokuni Higashiomiya Medical Center
  - Saitama, Japan, 338-0837
    - Sanai Hospital
  - Saitama, Japan, 339-0033
    - Iwatsuki-minami Hospital
  - Shizuoka, Japan, 420-8630
    - Shizuoka City Shizuoka Hospital
  - Wakayama, Japan, 640-8158
    - Saiseikai Wakayama Hospital
- Aichi
  - Kasugai, Aichi, Japan, 486-8510
    - Kasugai Municipal Hospital
  - Nagoya, Aichi, Japan, 457-8510
    - Japan Community Healthcare. Organization Chukyo Hospital
  - Nagoya, Aichi, Japan, 466-8650
    - Japanese RedCross Aichi Medical Center Nagoya Daini Hospital
  - Toyota, Aichi, Japan, 470-0396
    - Toyota Kosei Hospital
- Chiba
  - Funabashi, Chiba, Japan, 274-8503
    - Chiba Tokushukai Hospital
  - Inzai, Chiba, Japan, 270-1694
    - Nippon Medical School Chiba Hokusoh Hospital
  - Kisarazu, Chiba, Japan, 292-8535
    - Kimitsu Chuo Hospital
  - Sakura, Chiba, Japan, 285-8741
    - Toho University Sakura Medical Center
- Ehime
  - Matsuyama, Ehime, Japan, 790-0067
    - Matsuyama Shimin Hospital
- Fukuoka
  - Fukutsu, Fukuoka, Japan, 811-3298
    - Munakata Suikokai General Hospital
  - Itoshima, Fukuoka, Japan, 819-1104
    - Nakamura Cardiovascular Clinic
  - Kitakyushu, Fukuoka, Japan, 802-8555
    - Kokura Memorial Hospital
  - Kitakyushu, Fukuoka, Japan, 805-8508
    - Steel Memorial Yawata Hospital
  - Nakagawa, Fukuoka, Japan, 811-1244
    - Go Neurosurgical Clinic
  - Onga-gun, Fukuoka, Japan, 807-0051
    - Fukuoka Shin Mizumaki Hospital
  - Onga-gun, Fukuoka, Japan, 811-4342
    - Onga Nakama Medical Association Onga Hospital
  - Yanagawa, Fukuoka, Japan, 832-0077
    - Yanagawa Hospital
- Fukushima
  - Shirakawa, Fukushima, Japan, 961-0005
    - Shirakawa Kosei General Hospital
- Gunma
  - Takasaki, Gunma, Japan, 370-0829
    - National Hospital Organization Takasaki General Medical Center
- Hiroshima
  - Aki-gun, Hiroshima, Japan, 735-8585
    - Mazda Hospital of Mazda Motor Corporation
- Hokkaido
  - Asahikawa, Hokkaido, Japan, 070-8610
    - Asahikawa City Hospital
  - Hakodate, Hokkaido, Japan, 041-8512
    - Hakodate National Hospital
  - Hakodate, Hokkaido, Japan, 041-8680
    - Hakodate Municipal Hospital
  - Sapporo, Hokkaido, Japan, 003-0026
    - Matsuda Cardiovascular clinic
  - Sapporo, Hokkaido, Japan, 006-0852
    - Mita Internist and Cardiology Clinic
  - Sapporo, Hokkaido, Japan, 006-8555
    - Teine Keijinkai Hospital
  - Sapporo, Hokkaido, Japan, 062-0003
    - Hanaoka Seishu Memorial Hospital
  - Sapporo, Hokkaido, Japan, 063-0826
    - Miyanosawa Clinic of Internal Medicine and Cardiology
  - Sapporo, Hokkaido, Japan, 064-8570
    - Miyanomori Memorial Hospital
  - Sapporo, Hokkaido, Japan, 065-0033
    - Sapporo Higashi Tokushukai Hospital
  - Tomakomai, Hokkaido, Japan, 053-8506
    - Oji General Hospital
  - Tomakomai, Hokkaido, Japan, 053-8567
    - Tomakomai City Hospital
- Hyogo
  - Akashi, Hyogo, Japan, 674-0063
    - Akashi Medical Center
  - Amagasaki, Hyogo, Japan, 660-8550
    - Hyogo Prefectural Amagasaki General Medical Center
  - Himeji, Hyogo, Japan, 670-8560
    - Hyogo Prefectural Harima-Himeji General Medical Center
  - Kawanishi, Hyogo, Japan, 666-0125
    - The Veritas Hospital
  - Kobe, Hyogo, Japan, 650-0047
    - Kobe City Medical Center General Hospital
  - Takarazuka, Hyogo, Japan, 665-0873
    - Higashi Takarazuka Satoh Hospital
- Ibaraki
  - Higashiibaraki, Ibaraki, Japan, 311-3193
    - National hospital Organization Mito Medical Center
  - Kasama, Ibaraki, Japan, 309-1793
    - Ibaraki Prefectural Central Hospital
  - Mito, Ibaraki, Japan, 311-4198
    - Mito Saiseikai General Hospital
  - Toride, Ibaraki, Japan, 302-0022
    - JA Toride Medical Center
  - Tsuchiura, Ibaraki, Japan, 300-0028
    - Tsuchiura Kyodo General Hospital
- Ishikawa
  - Hakusan, Ishikawa, Japan, 924-8588
    - Public Central Hospital of Matto Ishikawa
  - Kahoku-gun, Ishikawa, Japan, 920-0293
    - Kanazawa Medical University Hospital
  - Kanazawa, Ishikawa, Japan, 920-8650
    - National Hospital Organization Kanazawa Medical Center
  - Kanazawa, Ishikawa, Japan, 920-8530
    - Ishikawa Prefectural Central Hospital
  - Komatsu, Ishikawa, Japan, 923-8560
    - Komatsu Municipal Hospital
- Iwate
  - Morioka, Iwate, Japan, 020-0066
    - Iwate Prefectural Central Hospital
- Kagawa
  - Kanonji, Kagawa, Japan, 769-1695
    - Mitoyo General Hospital
  - Takamatsu, Kagawa, Japan, 760-8557
    - Kagawa Prefectural Central Hospital
- Kagoshima
  - Kanoya, Kagoshima, Japan, 893-0015
    - Oosumikanoya Hospital
- Kanagawa
  - Fujisawa, Kanagawa, Japan, 251-8550
    - Fujisawa City Hospital
  - Miura-gun, Kanagawa, Japan, 240-0116
    - Hayama Heart Center
  - Yokohama, Kanagawa, Japan, 232-0024
    - Yokohama City University Medical Center
  - Yokohama, Kanagawa, Japan, 247-8581
    - Yokohama Sakae Kyosai Hospital
- Mie
  - Suzuka, Mie, Japan, 513-8630
    - Suzuka Chuo General Hospital
- Miyagi
  - Sendai, Miyagi, Japan, 981-3133
    - Sendai Cardiovascular Center
  - Sendai, Miyagi, Japan, 983-8512
    - Tohoku Medical and Pharmaceutical University Hospital
- Nagano
  - Azumino, Nagano, Japan, 399-8292
    - Japan Red Cross Society Azumino Hospital
  - Iida, Nagano, Japan, 395-8505
    - Iida Hospital
  - Kitaazumi-gun, Nagano, Japan, 399-8695
    - North Alps Medical Center Azumi Hospital
  - Komoro, Nagano, Japan, 384-8588
    - Asama Nanroku Komoro Medical Center
  - Nakano, Nagano, Japan, 383-8505
    - Hokushin General Hospital
  - Suwa, Nagano, Japan, 392-8510
    - Japanese Red Cross Society Suwa Hospital
- Okinawa
  - Naha, Okinawa, Japan, 902-8511
    - R.I.A.C Naha City Hospital
  - Urasoe, Okinawa, Japan, 901-2132
    - Urasoe General Hospital
- Osaka
  - Kishiwada, Osaka, Japan, 596-0042
    - Kishiwada Tokushukai Hospital
  - Suita, Osaka, Japan, 565-0862
    - Osaka Saiseikai Senri Hospital
  - Yao, Osaka, Japan, 581-0011
    - Yao Tokushukai General Hospital
- Saitama
  - Ageo, Saitama, Japan, 362-8588
    - Ageo Central General Hospital
  - Kawaguchi, Saitama, Japan, 333-0842
    - Kawaguchi Cardiovascular and Respiratory Hospital
- Shiga
  - Omihachiman, Shiga, Japan, 523-0082
    - Omihachiman Community Medical Center
- Shimane
  - Hamada, Shimane, Japan, 697-8511
    - National Hospital Organization Hamada Medical Center
- Tochigi
  - Shimotsuga-gun, Tochigi, Japan, 321-0293
    - Dokkyo Medical University Hospital
- Tokyo
  - Bunkyo-ku, Tokyo, Japan, 113-8519
    - Tokyo Medical and Dental University Hospital
  - Chuo-ku, Tokyo, Japan, 103-0027
    - Tokyo-Eki Center-building Clinic
  - Hachioji, Tokyo, Japan, 192-0918
    - Minamino Cardiovascular Hospital
  - Hachioji, Tokyo, Japan, 193-0811
    - Tokyo Angel Hospital
  - Itabashi-ku, Tokyo, Japan, 173-8610
    - Nihon University Itabashi Hospital
  - Machida, Tokyo, Japan, 194-0023
    - Machida Municipal Hospital
  - Meguro-ku, Tokyo, Japan, 152-8902
    - National Hospital Organization Tokyo Medical Center
  - Minato, Tokyo, Japan, 108-0073
    - Tokyo Saiseikai Central Hospital
  - Shinjuku-ku, Tokyo, Japan, 169-0073
    - Tokyo Yamate Medical Center
  - Suginami-ku, Tokyo, Japan, 168-0065
    - NewHeart Watanabe Institute
  - Tachikawa, Tokyo, Japan, 190-0014
    - National Hospital Organization Disaster Medical Center
- Yamaguchi
  - Shunan, Yamaguchi, Japan, 745-8522
    - JCHO Tokuyama Central Hospital
- Yamanashi
  - Kofu, Yamanashi, Japan, 400-8506
    - Yamanashi Prefectural Central Hospital
Korea, Republic of
- - Busan, Korea, Republic of, 49201
    - Dong-A University Hospital
  - Daegu, Korea, Republic of, 42601
    - Keimyung University Dongsan Medical Center
  - Gwangju, Korea, Republic of, 501-757
    - Chonnam National University Hospital
  - Incheon, Korea, Republic of, 21565
    - Gachon University Gil Medical Center
  - Seongbuk, Korea, Republic of, 136-705
    - Korea University Anam Hospital
  - Seoul, Korea, Republic of, 138-736
    - Asan Medical Center
  - Seoul, Korea, Republic of, 110-744
    - Seoul National University Hospital
  - Seoul, Korea, Republic of, 156-755
    - Chung-Ang University Hospital
  - Seoul, Korea, Republic of, 6351
    - Samsung Medical Center
  - Seoul, Korea, Republic of, 3722
    - Severance Hospital, Yonsei University Health System
- Busan Gwang''yeogsi
  - Busan, Busan Gwang''yeogsi, Korea, Republic of, 49241
    - Pusan National University Hospital
- Daegu Gwang''yeogsi
  - Daegu, Daegu Gwang''yeogsi, Korea, Republic of, 41944
    - Kyungpook National University Hospital
- Gang''weondo
  - Wonju, Gang''weondo, Korea, Republic of, 26426
    - Yonsei University Wonju Christian Hospital
- Gyeonggido
  - Anyang, Gyeonggido, Korea, Republic of, 431-070
    - Hallym University Sacred Heart Hospital
  - Bucheon-si,, Gyeonggido, Korea, Republic of, 137-701
    - The Catholic University of Korea Seoul St. Mary's Hospital
  - Seongnam-si, Gyeonggido, Korea, Republic of, 13496
    - Bundang Cha Hospital
  - Seongnam-si, Gyeonggido, Korea, Republic of, 463-707
    - Seoul National University Bundang Hospital
  - Suwon, Gyeonggido, Korea, Republic of, 443-721
    - Ajou University Hospital
  - Uijeongbu, Gyeonggido, Korea, Republic of, 480-130
    - Uijeongbu St. Mary's Hospital
- Seoul Teugbyeolsi
  - Seoul, Seoul Teugbyeolsi, Korea, Republic of, 03312
    - The Catholic Univ. of Korea Eunpyeong St. Mary's Hospital
Latvia
- - Daugavpils, Latvia, LV-5417
    - Daugavpils Regional Hospital
  - Daugavpils, Latvia, LV-5401
    - Doctor's Practice in Cardiology
  - Daugavpils, Latvia, LV-5401
    - SIA ARI Med
  - Kuldiga, Latvia, LV-3301
    - Rutas Eglites GP Practice
  - Liepaja, Latvia, LV-3414
    - Liepaja Regional Hospital
  - Ogre, Latvia, LV-5001
    - Lija Mora physician practice
  - Riga, Latvia, LV-1002
    - P. Stradins Clinical University Hospital
  - Riga, Latvia, LV-1001
    - 1st Riga Clinical Hospital
  - Riga, Latvia, LV-1011
    - Health Center Adoria
  - Riga, Latvia, LV-1012
    - Health Center 4
  - Riga, Latvia, LV-1038
    - Riga East Clinical University Hospital "Gailezers"
  - Riga, Latvia, LV-1050
    - APS Clinic
  - Valmiera, Latvia, LV-4201
    - Vidzemes Hospital
  - Ventspils, Latvia, LV-3601
    - Gita Rancane - cardiology private practice
Lithuania
- - Kaunas, Lithuania, LT-44320
    - LUHS Kauno Hospital (Laisves ave.)
  - Kaunas, Lithuania, LT-47144
    - LUHS Kauno Hospital (Josvainiu str.)
  - Kaunas, Lithuania, LT-49287
    - Kardiolitos klinikos / BMP
  - Kaunas, Lithuania, LT-49449
    - Saules family medicine center
  - Kaunas, Lithuania, LT-50161
    - Hospital of LT University of Health Sciences Kaunas Clinics
  - Kaunas, Lithuania, LT-50177
    - InMedica clinic Zaliakalnis
  - Kaunas, Lithuania, 45462
    - Mariu klinika JSC
  - Klaipeda, Lithuania, LT-92288
    - Klaipeda Seamen's Hospital
  - Klaipeda, Lithuania, LT-91131
    - Kardiologijos ir reabilitacijos klinika
  - Klaipeda, Lithuania, LT-92231
    - Klaipeda Republican Hospital
  - Klaipeda, Lithuania, LT-92288
    - Klaipeda Seamen's Hospital Cardiology Department I
  - Siauliai, Lithuania, 76231
    - Siauliai Republican hospital
  - Vilnius, Lithuania, LT-08661
    - Vilnius University Hospital Santaros Klinikos
  - Vilnius, Lithuania, LT-08431
    - InMedica Clinic Santariskes
Malaysia
- - Alor Setar, Malaysia, 5460
    - Hospital Sultanah Bahiyah
  - Cheras, Malaysia, 56000
    - University Hospital Kebangsaan Malaysia
  - Johor Bahru, Malaysia, 80100
    - Hospital Sultanah Aminah
  - Kelantan, Malaysia, 15200
    - Hospital Raja Perempuan Zainab II
  - Kelantan, Malaysia, 16150
    - Hospital Universiti Sains Malaysia
  - Kuala Lumpur, Malaysia, 59100
    - University Malaya Medical Centre
  - Kuala Lumpur, Malaysia
    - Institute Jantung Negara
  - Pahang, Malaysia, 25100
    - Hospital Tengku Ampuan Afzan
  - Pulau Pinang, Malaysia, 13700
    - Hospital Seberang Jaya
  - Sarawak, Malaysia, 94300
    - Sarawak Heart Centre
  - Sarawak, Malaysia
    - Sarawak General Hospital
  - Selangor, Malaysia, 43000
    - Hospital Serdang
  - Selangor, Malaysia, 43400
    - Hospital Pengajar Universiti Putra Malaysia
  - Selangor, Malaysia, 47000
    - Hospital Al-Sultan Abdullah (UiTM Hospital)
  - Seremban, Malaysia, 70300
    - Seremban Hospital Neurology
Netherlands
- - Amstelveen, Netherlands, 1186 AM
    - Ziekenhuis Amstelland
  - Amsterdam, Netherlands, 1105 AZ
    - Academisch Medisch Centrum (AMC)
  - Apeldoorn, Netherlands, 7334 DZ
    - Gelre Ziekenhuizen Apeldoorn / Cardiology
  - Arnhem, Netherlands, 6815 AD
    - Rijnstate | Arnhem - Internal Medicine Department - Vascular Research
  - Beverwijk, Netherlands, 1942 LE
    - Rode Kruis Ziekenhuis
  - Blaricum, Netherlands, 1261 AN
    - Tergooiziekenhuizen-Blaricum
  - Breda, Netherlands, 4818 CK
    - Amphia Breda | Department of Cardiology, BMC Research
  - Den Haag, Netherlands, 2545 AA
    - HagaZiekenhuis | Cardiology Department
  - Dirksland, Netherlands, 3247 BW
    - Van Weel-Bethesda Ziekenhuis
  - Dordrecht, Netherlands, 3318 AT
    - Albert Schweitzer Ziekenhuis, Dordwijk
  - Eindhoven, Netherlands, 5623 EJ
    - Catharina Hospital | Cardiology Department
  - Emmen, Netherlands, 7824 AA
    - Treant locatie Bethesda
  - Enschede, Netherlands, 7611 JH
    - MST|TCT-Foundation Cardiovascular Research and Education
  - Gorinchem, Netherlands, 4204 AA
    - Beatrixziekenhuis
  - Groningen, Netherlands, 9700 RB
    - Universitair Medisch Centrum Groningen
  - Groningen, Netherlands, 9728 NT
    - Martini Ziekenhuis, Locatie van Swieten
  - Haarlem, Netherlands, 2035 RC
    - Spaarne Gasthuis - locatie Zuid
  - Hardenberg, Netherlands, 7772 SE
    - Saxenburgh Medisch Centrum
  - Roosendaal, Netherlands, 4708 AE
    - Bravis Ziekenhuis
  - Tiel, Netherlands, 4002 WP
    - Ziekenhuis Rivierenland | Cardiology Research Department
  - Venlo, Netherlands, 5912 BL
    - VieCuri - Medisch Centrum voor Noord-Limburg locatie Venlo
  - Zaandam, Netherlands, 1502 DV
    - Zaans Medisch Centrum
- Zeeland
  - Goes, Zeeland, Netherlands, 4462RA
    - Admiraal de Ruyterziekenhuis
Norway
- - Bodø, Norway, 8092
    - Nordlandssykehuset HF
  - Drammen, Norway, 3004
    - Vestre Viken HF - Drammen Sykehus Cardiology
  - Elverum, Norway, 2409
    - Sykehuset Innlandet HF Elverum
  - Fredrikstad, Norway, NO-1603
    - Sykehuset Østfold HF Fredrikstad
  - Gjettum, Norway, 1346
    - Vestre Viken HF - Bærum Sykehus Cardiology
  - Gjøvik, Norway, 2819
    - Sykehuset Innlandet HF Gjøvik
  - Harstad, Norway, 9406
    - Universitetssykehuset i Nord Norge, Harstad
  - Lillehammer, Norway, 2609
    - Sykehuset Innlandet HF Lillehammer
  - Molde, Norway, 6407
    - Helse Møre og Romsdal HF
  - Nordbyhagen, Norway, 1478
    - Akershus University Hospital Cardiology Department
  - Oslo, Norway, 0027
    - Oslo Universitetssykehus HF, Rikshospitalet
  - Oslo, Norway, 0319
    - Diakonhjemmets sykehus
  - Oslo, Norway, 0450
    - OUS Ullevål Cardiology Department
  - Skedsmokorset, Norway, 2020
    - Skedsmo Medisinske senter
  - Stavanger, Norway, 4011
    - Stavanger Universitetssjukehus
  - Tromsø, Norway, 9038
    - Universitetssykehuset Nord-Norge HF Tromsø
  - Ålesund, Norway, 6026
    - Ålesund Sykehus, Kardiologisk Seksjon
Poland
- - Bialystok, Poland, 15-276
    - Uniwersytecki Szpital Kliniczny w Bialymstoku
  - Bialystok, Poland, 15-704
    - KLIMED Marek Klimkiewicz
  - Bydgoszcz, Poland, 85-065
    - MICS Centrum Medyczne Bydgoszcz
  - Bydgoszcz, Poland, 85-231
    - Centrum Medyczne KerMed
  - Gdansk, Poland, 80-214
    - Uniwersyteckie Centrum Kliniczne
  - Grodzisk Mazowiecki, Poland, 05 825
    - Samodzielny Publiczny Specjalistyczny Szpital Zachodni
  - Katowice, Poland, 40-156
    - CLINICAL MEDICAL RESEARCH Sp. z o. o.
  - Katowice, Poland, 40-748
    - Vita Longa Sp. z o.o.
  - Krakow, Poland, 31-271
    - Unicardia Specjalistyczne Centrum Leczenia Ch.Serca i Naczyn
  - Lodz, Poland, 90-242
    - Centrum Terapii Wspolczesnej
  - Lodz, Poland, 91-034
    - MED-GASTR Sp. z o.o. Sp. k.
  - Lowicz, Poland, 99-400
    - Centrum Medyczne Ogrodowa G. i M. Kania Lekarze i Lekarze Dentysci Spólka Partnerska z siedziba w Skierniewicach
  - Lublin, Poland, 20-049
    - 1 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ w Lublinie
  - Lublin, Poland, 20-857
    - NZOZ "Twoja Przychodnia" Sp. z o.o.
  - Olsztyn, Poland, 10-117
    - Etyka Osrodek Badan Klinicznych
  - Olsztyn, Poland, 10-010
    - FutureMeds sp. z o. o.
  - Piaseczno, Poland, 05-500
    - NZOZ Heureka
  - Piotrkow Trybunalski, Poland, 97-300
    - Irmed Klimkiewicz, Rudziewicz-Kowalska Sp.j.
  - Poznan, Poland, 60-529
    - Solumed Centrum Medyczne
  - Pulawy, Poland, 24-100
    - KO-MED Centra Kliniczne Pulawy
  - Rzeszow, Poland, 35-205
    - EMED Centrum Uslug Medycznych Ewa Smialek
  - Skierniewice, Poland, 96-100
    - Clinmedica Research sp. z o.o.
  - Staszow, Poland, 28-200
    - "Nowe Zdrowie-Ck" Kieltucki I Wspolnicy Spolka Jawna
  - Warszawa, Poland, 00-465
    - NBR Polska Tomasz Klodawski
  - Warszawa, Poland, 02-637
    - Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji
  - Zamosc, Poland, 22-400
    - KO-MED Centra Kliniczne Zamosc
Portugal
- - Almada, Portugal, 2801-951
    - Hospital Garcia de Orta | Research Department
  - Braga, Portugal, 4710-243
    - Centro Clinico Academico Braga | Braga, Portugal
  - Coimbra, Portugal, 3004-561
    - Centro Hospitalar e Universitario de Coimbra, E.P.E. | Department of Cardiology, Research Unit
  - Guilhufe, Portugal, 4564-007
    - Centro Hospitalar de Tamega e Sousa | Hospital Padre Americo - Cardiology Department
  - Leiria, Portugal, 2410-197
    - Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center
  - Lisboa, Portugal, 1449-005
    - Centro Hospitalar de Lisboa Ocidental | Clin Res Dept
  - Lisboa, Portugal, 1649-028
    - Centro Hospitalar Universitário de Lisboa Norte | Heart and Vessels Department
  - Lisboa, Portugal, 1500-458
    - Lusiadas | Hospital Lusiadas Lisboa - Lusiadas Knowledge Center
  - Lisboa, Portugal, 1500-650
    - Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica
  - Porto, Portugal, 4200-319
    - CHUSJ - Hospital Sao Joao
  - Vila Nova de Gaia, Portugal, 4434-502
    - Centro Hospitalar Vila Nova de Gaia/Espinho | Unit 1 - Clinical Research Office
  - Vila Real, Portugal, 5000-508
    - Centro Hospitalar De Tras os Montes e Alto Douro, EPE | Hospital Sao Pedro - Centro de investigacao clinica
- Braga
  - Guimaraes, Braga, Braga, Portugal, 4835-044
    - Hospital da Senhora da Oliveira | Clinical Research Department
- Castelo Branco
  - Covilha, Castelo Branco, Portugal, 6200-251
    - Centro Hospitalar Universitario Cova de Beira | Clinical Research Department
- Porto
  - Matosinhos, Porto, Portugal, 4464-513
    - ULSM - Hospital Pedro Hispano
- Santarém
  - Riachos, Santarém, Portugal, 2350-325
    - Ucardio | Cardiology Department
- Setúbal
  - Setubal, Setúbal, Portugal, 2900-722
    - Hospital da Luz - Setubal
Romania
- - Baia Mare, Romania, 430031
    - Sp. Judetean de Urgenta Dr. Constantin Opris Baia Mare
  - Braila, Romania, 810318
    - Emergency County Hospital, Braila
  - Brasov, Romania, 500283
    - S.C. Centrul Medical de Diagn si Tratam Ambulator Neomed SRL
  - Brasov, Romania
    - S.C Thera Card S.R.L
  - Bucharest, Romania, 022322
    - Emergency Institute for Cardiovascular Diseases
  - Bucharest, Romania, 042122
    - Spitalul Clinic de Urgenta Sf. Ioan
  - Bucuresti, Romania, 020125
    - Spitalul Clinic Colentina
  - Bucuresti, Romania, 022322
    - Emergency Institute for Cardiovascular Diseases
  - Bucuresti, Romania, 050098
    - Spitatul Universitar de Urgenta Bucuresti
  - Cluj Napoca, Romania, 400001
    - Niculae Stancioiu Heart Institute Cluj-Napoca
  - Cluj Napoca, Romania, 400300
    - Spitalul Clinic de Recuperare Cluj-Napoca
  - Cluj-Napoca, Romania, 400015
    - Cardiomed
  - Pitesti, Romania
    - S.C. Sal Med SRL
  - Satu Mare, Romania, 440055
    - Spitalul Judetean de Urgenta Satu Mare
  - Suceava, Romania, 720237
    - Spitalul de urgenta Sf. Ioan Cel Nou
  - Targu Mures, Romania, 540124
    - S.C. Cardio Med S.R.L.
  - Targu Mures, Romania, 540136
    - Emergency Institute of Cardiovascular Diseases & Transplant
  - Timisoara, Romania, 300310
    - Timisoara Institute of Cardiovascular Diseases
- Mures
  - Targu Mures, Mures, Romania
    - CMI. Dr. Podoleanu Cristian
- Timis
  - Timisoara, Timis, Romania, 300254
    - Municipal Clinical Emergency Hospital of Timisoara
Singapore
- - Singapore, Singapore, 119074
    - National University Hospital
  - Singapore, Singapore, 308433
    - Tan Tock Seng Hospital
  - Singapore, Singapore, 529889
    - Changi General Hospital
  - Singapore, Singapore, 544886
    - Sengkang General Hospital
  - Singapore, Singapore, 169609
    - National Heart Centre Singapore
  - Singapore, Singapore, 609606
    - Ng Teng Fong General Hospital
  - Singapore, Singapore, 519457
    - SingHealth Polyclinics - Pasir Ris
Slovakia
- - Bardejov, Slovakia, 085 01
    - Alian s.r.o.
  - Bratislava, Slovakia, 821 07
    - GALENUM s.r.o.
  - Bratislava, Slovakia, 84107
    - Kardiosanus | Bratislava, Slovakia
  - Brezno, Slovakia, 977 01
    - Nemocnica s poliklinikou Brezno, n.o.
  - Kosice, Slovakia, 040 11
    - KARDIO R s.r.o.
  - Kosice, Slovakia, 040 01
    - Medical Group Kosice s.r.o. | Kosice, Slovakia
  - Levice, Slovakia, 934 01
    - KARDIO-ANGIO s.r.o.
  - Levoca, Slovakia, 05401
    - KardioLEV s.r.o.
  - Lucenec, Slovakia, 984 01
    - KardioMed s.r.o.
  - Lucenec, Slovakia, 984 01
    - Internal and Diabetes Clinic - IN-DIA s.r.o. | Lucenec, Slovakia
  - Lucenec, Slovakia, 98401
    - KARDIO 1 | Lucenec, Slovakia
  - Namestovo, Slovakia, 02901
    - ORALEK, s.r.o.
  - Nitra, Slovakia, 949 88
    - Specializovana nemocnica sv. Svorada Zobor, n.o.
  - Nitra, Slovakia, 94901
    - Kardiocentrum Nitra | Cardiology Clinic - Outpatient Department
  - Nove Zamky, Slovakia, 940 02
    - KaCH, s.r.o.
  - Piestany, Slovakia, 92101
    - BENIMED s.r.o.
  - Presov, Slovakia, 080 01
    - MEDISPOL s.r.o.
  - Presov, Slovakia, 080 01
    - Medikard | Department of Internal Medicine
  - Svidnik, Slovakia, 089 01
    - Interna SK s.r.o.
  - Trnava, Slovakia, 91701
    - Kardiologicka ambulancia Trnava, MUDr. Vladimir Macek
  - Zilina, Slovakia, 01001
    - Medivasa s.r.o.
Spain
- - A Coruña, Spain, 15006
    - University Hospital of A Coruna | Cardiology department
  - Alicante, Spain, 03010
    - Hospital General Universitario de Alicante Doctor Balmis | Cardiology Department
  - Barcelona, Spain, 08023
    - Hospital Quironsalud Barcelona | Internal Medicine Department
  - Barcelona, Spain, 08025
    - Hospital de la Santa Creu i Sant Pau | Cardiology Department
  - Barcelona, Spain, 08035
    - Vall d'Hebron Barcelona Hospital Campus | Vall d'Hebron Hospital Universitario - Cardiology Department
  - Madrid, Spain, 28006
    - Hospital Universitario de La Princesa | Internal Medicine Department
  - Madrid, Spain, 28041
    - H. Universitario 12 de Octubre - Cardiologia
  - Madrid, Spain, 28046
    - Hospital Universitario La Paz | Cardiology Department - AF, Stroke Prevention
  - Madrid, Spain, 28046
    - Hospital Universitario La Paz | IdiPAZ - Neurology Department
  - Madrid, Spain, 28034
    - Hospital Universitario Ramon y Cajal | Departamento de Medicina Interna
  - Murcia, Spain, 30120
    - Hospital Clinico Universitario Virgen de la Arrixaca | Cardiology Department
  - Sevilla, Spain, 41013
    - Hospital Universitario Virgen del Rocio | Hospital General - Departmaneto de Cardiologia y Cirugia Cardiovascular
  - Valencia, Spain, 46026
    - La Fe University and Polytechnic Hospital | Cardiology Department
  - Valencia, Spain, 46014
    - Hospital General Universitario de Valencia | Cardiology Department
- A Coruña
  - Ferrol, A Coruña, Spain, 15405
    - Complejo Hospitalario Universitario de Ferrol | Hospital Naval - Unidad de Hipertensión Arterial
  - Santiago de Compostela, A Coruña, Spain, 15706
    - Hospital Clinico Universitario de Santiago de Compostela | Cardiology Department
- Asturias
  - Oviedo, Asturias, Spain, 33006
    - Hospital Universitario Central de Asturias | Servicio de Cardiologia
- Barcelona
  - L'Hospitalet de Llobregat, Barcelona, Spain, 08907
    - Hospital Universitari de Bellvitge | Bellvitge Biomedical Research Institute - Cardiology - AF, Stroke Prevention
- Cádiz
  - Sanlucar de Barrameda, Cádiz, Spain, 11540
    - Jose Manuel Pascual Pascual S.A. | Hospital Virgen del Camino - Internal Medicine Department
  - Villamartin, Cádiz, Spain, 11650
    - Jose Manuel Pascual Pascual S.A. | Hospital Virgen de las Montanas - Internal Medicine Department
- Málaga
  - Malaga, Málaga, Spain, 29010
    - Hospital Universitario Virgen de la Victoria | Cardiology Department
- Sevilla
  - Lebrija, Sevilla, Spain, 41740
    - Hospital Alta Resolucion de Lebrija | Cardiology Service Department
  - Utrera, Sevilla, Spain, 41710
    - Hospital Alta Resolucion de Utrera | Cardiology Service Department
Sweden
- - Borås, Sweden, 501 82
    - Södra Älvsborgs Sjukhus
  - Falun, Sweden, 791 82
    - Falu Lasarett
  - Göteborg, Sweden, 416 85
    - SU/Östra
  - Helsingborg, Sweden
    - Helsingborgs Lasarett
  - Linköping, Sweden, 581 85
    - Universitetssjukhuset i Linköping
  - Lund, Sweden, 222 21
    - Clemenstorget Hjärtmottagning
  - Lund, Sweden, 222 42
    - Skanes Universitetssjukhus
  - Mölndal, Sweden, 431 80
    - SU/Mölndal
  - Norrköping, Sweden, 601 82
    - Vrinnevisjukhuset
  - Skellefteå, Sweden, 931 86
    - Skellefteå Lasarett
  - Stockholm, Sweden, 171 76
    - Karolinska Universitetssjukhuset
  - Stockholm, Sweden, 182 88
    - Danderyds sjukhus
  - Stockholm, Sweden, 118 83
    - Södersjukhuset AB
  - Stockholm, Sweden, 141 86
    - Karolinska Universitetssjukhuset Huddinge Stockholm
  - Umea, Sweden, 901 85
    - Norrlands Universitetssjukhus, Umea
  - Uppsala, Sweden
    - Akademiska sjukhuset
  - Västerås, Sweden, 721 89
    - Vastmanlands Sjukhus Vasteras
  - Örebro, Sweden, 701 85
    - Universitetssjukhuset Örebro
Switzerland
- - Baden, Switzerland, 5404
    - Kantonsspital Baden
  - Bern, Switzerland, 3010
    - Inselspital Universitatsspital Bern
  - Lugano, Switzerland, 6900
    - Cardiocentro Ticino
  - Zürich, Switzerland, 8091
    - Universitätsspital Zürich
- Aargau
  - Aarau, Aargau, Switzerland, 5001
    - Kantonsspital Aarau
- Sankt Gallen
  - Saint Gallen, Sankt Gallen, Switzerland, 1009
    - Kantonsspital St. Gallen
Taiwan
- - Changhua, Taiwan, 50006
    - Changhua Christian Hospital
  - Hsinchu, Taiwan, 300
    - Mackay Memorial Hospital - Hsinchu Branch
  - Hualien, Taiwan, 970
    - Buddhist Tzu-Chi General Hospital, Hualien
  - Kaohsiung, Taiwan, 833
    - Chang Gung Memorial Hospital Kaohsiung
  - Kaohsiung, Taiwan
    - E-DA hospital
  - Kaohsiung, Taiwan, 81362
    - Veterans General Hospital
  - Taichung, Taiwan, 40447
    - China Medical University Hospital
  - Taichung, Taiwan, 40705
    - Taichung Veterans General Hospital
  - Taichung, Taiwan, 40201
    - Chung Shan Medical University Hospital
  - Tainan, Taiwan, 704
    - National Cheng Kung University Hospital
  - Taipei, Taiwan, 100
    - National Taiwan University Hospital
  - Taipei, Taiwan, 11217
    - Taipei Veterans General Hospital
  - Taipei, Taiwan, 110
    - Taipei Medical University Hospital
  - Taipei, Taiwan, 10449
    - Mackay Memorial Hospital
  - Taipei, Taiwan, 106
    - Cathay General Hospital
  - Taipei, Taiwan, 116
    - Taipei Municipal Wanfang Hospital
  - Taipei City, Taiwan, 114
    - Tri-Service General Hospital
  - Taoyuan, Taiwan, 33305
    - Chang Gung Memorial Hospital at Linkou
- Ilan
  - Yilan City, Ilan, Taiwan, 260006
    - National Yang Ming Chiao Tung University Hospital
- Kaohsiung
  - Kaohsiung City, Kaohsiung, Taiwan, 807377
    - Kaohsiung Medical University Chung-Ho Memorial Hospital
- Tainan
  - Taikang, Tainan, Taiwan, 71004
    - Chi Mei Medical Center
- Taipei
  - New Taipei City, Taipei, Taiwan, 25160
    - Mackay Memorial Hospital Tamsui Branch
  - Taipei City, Taipei, Taiwan, 111
    - Shin Kong Wu Ho-Su Memorial Hospital
Turkey
- - Adana, Turkey, 4522
    - S.B.U. Adana Sehir Egitim ve Arastirma Hastanesi
  - Afyonkarahisar, Turkey, 03218
    - Afyonkarahisar Saglik Bilimleri Universitesi
  - Ankara, Turkey, 06490
    - Baskent Universitesi Tip Fakultesi Hastanesi
  - Ankara, Turkey, 06800
    - Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital
  - Antalya, Turkey, 07003
    - Akdeniz Universitesi Tip Fakultesi Hastanesi
  - Corum, Turkey, 19030
    - Hitit Universitesi Tip Fakultesi
  - Erzurum, Turkey, 25240
    - Ataturk Universitesi Tip Fakultesi
  - Eskisehir, Turkey, 26480
    - Eskisehir Osmangazi Universitesi Tip Fakultesi
  - Istanbul, Turkey, 34098
    - Istanbul Universitesi Cerrahpasa - Kardiyoloji Anabilim Dali
  - Istanbul, Turkey, 34899
    - Marmara Uni. Tip Fak. Pendik EAH Kardiyoloji
  - Istanbul, Turkey
    - Istanbul Mehmet Akif Ersoy Gogus Kalp Damar Cerrahisi E.A.H.
  - Izmir, Turkey, 35100
    - Dokuz Eylul Universitesi Tip Fakultesi
  - Izmir, Turkey, 35575
    - Izmir Ekonomi Universitesi Medikal Point Hastanesi
  - Kayseri, Turkey, 38039
    - Erciyes Universitesi Tip Fakultesi
  - Kocaeli, Turkey, 41380
    - Kocaeli Universitesi Tip Fakultesi
  - Kutahya, Turkey, 43040
    - Kutahya Saglik Bilimleri Uni. Evliya Celebi Egitim ve Arasti
  - Samsun, Turkey, 55090
    - Saglik Bilimleri Univ. Samsun EAH Kardiyoloji Departmani
United Kingdom
- - Cardiff, United Kingdom, CF5 4AD
    - Ely Bridge Medical Centre
  - Liverpool, United Kingdom, L14 3PE
    - Heart and Chest Hospital
  - London, United Kingdom, W6 8RF
    - Charing Cross Hospital
  - London, United Kingdom, SE5 9RS
    - King's College Hospital - NHS Foundation Trust
  - Wirral, United Kingdom, CH62 6EE
    - Future Meds - Bromborough
- Cambridgeshire
  - Ely, Cambridgeshire, United Kingdom, CB7 5SQ
    - Staploe Medical Centre
- Cheshire
  - Chester, Cheshire, United Kingdom, CH2 1UL
    - Countess of Chester Hospital
- Derbyshire
  - Chesterfield, Derbyshire, United Kingdom, S44 5BL
    - Chesterfield Royal Hospital
- Devon
  - Torbay, Devon, United Kingdom, TQ2 7AA
    - Torbay Hospital
- Dorset
  - Poole, Dorset, United Kingdom, BH15 2JB
    - Poole Hospital NHS Trust
- Glasgow City
  - Glasgow, Glasgow City, United Kingdom, G4 0SF
    - Glasgow Royal Infirmary | Stroke Unit
- Hampshire
  - Basingstoke, Hampshire, United Kingdom, RG24 9NA
    - North Hampshire Hospital
- Hertfordshire
  - Stevenage, Hertfordshire, United Kingdom, SG1 4AB
    - Lister Hospital
- Kent
  - Margate, Kent, United Kingdom, CT9 4AN
    - Queen Elizabeth the Queen Mother Hospital
- Leicestershire
  - Leicester, Leicestershire, United Kingdom, LE3 9QP
    - University Hospitals Leicester
- London
  - Harrow, London, United Kingdom, HA1 3UJ
    - Northwick Park Hospital
- North Ireland
  - Craigavon, North Ireland, United Kingdom, BT63 5QQ
    - Craigavon Area Hospital
- North Yorkshire
  - Middlesborough, North Yorkshire, United Kingdom, TS43BW
    - James Cook University Hospital South Tees
- Northumberland
  - Ashington, Northumberland, United Kingdom, NE63 9JJ
    - Wansbeck General Hospital
- Tyne And Wear
  - Newcastle, Tyne And Wear, United Kingdom, NE7 7DN
    - Freeman Hospital
- West Midlands
  - Birmingham, West Midlands, United Kingdom, B21 9RY
    - Soho Health Centre, Future Meds
  - Dudley, West Midlands, United Kingdom, DY1 2HQ
    - Russells Hall Hospital
- West Sussex
  - Chichester, West Sussex, United Kingdom, PO19 6SE
    - St Richard's Hospital
- Worcestershire
  - Worcester, Worcestershire, United Kingdom, WR5 1DD
    - Worcestershire Acute Hospital Trust
United States
- Alabama
  - Dothan, Alabama, United States, 36305
    - SEC Clinical Research
  - Fairhope, Alabama, United States, 36532
    - Eastern Shore Research Institute, LLC | Fairhope, AL
  - Mobile, Alabama, United States, 36608
    - Mobile Heart Specialists, PC
- Arkansas
  - Little Rock, Arkansas, United States, 72205
    - Arkansas Cardiology - Little Rock
- California
  - Covina, California, United States, 91723
    - Valley Clinical Trials, Inc. | Covina, CA
  - Culver City, California, United States, 90230
    - Science 37
  - Long Beach, California, United States, 90822
    - VA Long Beach Healthcare System
  - Los Angeles, California, United States, 90073
    - VA Greater Los Angeles Healthcare System
  - Newport Beach, California, United States, 92685
    - Radin Cardiovascular Medical Group, Inc.
  - Northridge, California, United States, 91324
    - Amicis Research Center | Northridge, CA
  - Santa Barbara, California, United States, 93102
    - Santa Barbara Cottage Hospital | Cardiology
  - Santa Rosa, California, United States, 95405
    - NorthBay Clinical Research, LLC | Santa Rosa, CA
  - Torrance, California, United States, 90502
    - Harbor - UCLA Medical Center
  - Torrance, California, United States, 90502-2004
    - Lundquist Institute Harbor-UCLA | Cardiac CT | Div of Cardio
  - Vista, California, United States, 92081
    - Blue Coast Research Center, LLC
  - West Hills, California, United States, 91307
    - Interventional Cardiology Medical Group | West Hills, CA
- Colorado
  - Littleton, Colorado, United States, 80120
    - South Denver Cardiology Associates, PC
- Connecticut
  - Norwalk, Connecticut, United States, 06851
    - Cardiology Associates of Fairfield County, P.C. | Stamford, CT
- Florida
  - Boynton Beach, Florida, United States, 33437
    - Florida Premier Cardiology
  - Boynton Beach, Florida, United States, 33472
    - Integrity Clinical Research | Cardiology Associates of South Florida
  - Bradenton, Florida, United States, 34209
    - Cardiovascular and Vein Center of Florida
  - Bradenton, Florida, United States, 34209
    - Nova Clinical Research | Brandenton, FL
  - Clearwater, Florida, United States, 33756
    - Clearwater Cardiovascular Associates | Clearwater, FL
  - Coral Gables, Florida, United States, 33134
    - Life Spring Research
  - Daytona Beach, Florida, United States, 32114
    - Cardiology Consultants, PA
  - Daytona Beach, Florida, United States, 32117
    - Cardiology Associates Research Company
  - Delray Beach, Florida, United States, 33446
    - Heller Heart Health
  - Gainesville, Florida, United States, 32608-1197
    - Malcom Randall VA Medical Ctr
  - Hialeah, Florida, United States, 33012
    - Indago Research & Health Center, Inc.
  - Inverness, Florida, United States, 34452
    - Nature Coast Clinical Research, LLC
  - Jacksonville, Florida, United States, 32209
    - University of Florida - Jacksonville
  - Longwood, Florida, United States, 32779
    - Heart Vein & Vascular | Longwood, FL
  - Naples, Florida, United States, 34102
    - Advanced Research for Health Improvement
  - Naples, Florida, United States, 34102-8143
    - Southwest Florida Research | Naples, FL
  - Palm Beach Gardens, Florida, United States, 33410
    - Cardiology Partners Clinical Research Institute
  - Pensacola, Florida, United States, 32501
    - Baptist Heart and Vascular/Cardiology Consultants
  - Port Charlotte, Florida, United States, 33592
    - Peace River Cardiovascular Center | Port Charlotte, FL
  - Saint Augustine, Florida, United States, 32086
    - East Coast Institute for Research, LLC - St Augustine
  - Saint Augustine, Florida, United States, 32086
    - St. Johns Center for Clinical Research
  - Sarasota, Florida, United States, 34239
    - Cardiovascular Center of Sarasota
  - Wellington, Florida, United States, 33449
    - Cardiology Partners
- Georgia
  - Atlanta, Georgia, United States, 30303
    - Grady Memorial Hospital
  - Cumming, Georgia, United States, 30041
    - NSC Research Inc
  - Dunwoody, Georgia, United States, 30338
    - Alta Pharmaceutical Research Center, LLC
  - Tucker, Georgia, United States, 30084
    - Atlanta Heart Specialists, LLC
- Idaho
  - Meridian, Idaho, United States, 83642
    - St. Luke's Health System | St. Luke's Clinic - Idaho Cardiology Associates
- Illinois
  - Glenview, Illinois, United States, 60026
    - Northshore Medical Center
  - Oak Brook, Illinois, United States, 60523
    - Affinity Health Research Institute | Oak Brook, IL
- Indiana
  - Elkhart, Indiana, United States, 46514
    - Midwest Cardiovascular Research and Education Foundation
  - Hammond, Indiana, United States, 46320
    - Cardiology Associates of Northwest Indiana, PC
  - Indianapolis, Indiana, United States, 46202
    - IU Health Physicians Cardiology
  - Richmond, Indiana, United States, 47374
    - Reid Physician Associates | Cardiology Department
- Iowa
  - Ames, Iowa, United States, 50010
    - Accellacare-Ames
- Kansas
  - Wichita, Kansas, United States, 67226
    - Kansas Nephrology Physicians, PA
- Kentucky
  - Lexington, Kentucky, United States, 40503
    - Baptist Health Lexington
  - Louisville, Kentucky, United States, 40207
    - Baptist Health Medical Group - Louisville Cardiology
  - Owensboro, Kentucky, United States, 42303
    - Research Integrity, LLC
- Louisiana
  - Alexandria, Louisiana, United States, 71301
    - Cambridge Medical Trials
  - Baton Rouge, Louisiana, United States, 70836
    - Ochsner Clinic Foundation
  - Covington, Louisiana, United States, 70433
    - Cardiovascular Associates Research, LLC
  - New Orleans, Louisiana, United States, 70121
    - Ochsner Medical Center - New Orleans
  - Slidell, Louisiana, United States, 70458
    - Louisiana Heart Center Research - Slidell
- Maine
  - Bangor, Maine, United States, 04401
    - Northeast Cardiology Associates
  - Scarborough, Maine, United States, 04039
    - MaineHealth Maine Medical Center | Maine Medical Partners Cardiology
- Maryland
  - Baltimore, Maryland, United States, 21229
    - St. Agnes Hospital
  - Baltimore, Maryland, United States, 21287
    - Johns Hopkins Hospital/Health System
  - Baltimore, Maryland, United States, 21215
    - LifeBridge Health | Sinai Hospital | Platelet and Thrombosis Research Department
  - Columbia, Maryland, United States, 21044
    - Johns Hopkins University
  - Fort Washington, Maryland, United States, 20744
    - Anderson Medical Research LLC
  - Silver Spring, Maryland, United States, 20904
    - White Oak Medical Center
- Michigan
  - Bay City, Michigan, United States, 48708
    - McLaren Bay Region Medical Center
  - Detroit, Michigan, United States, 48202
    - Henry Ford Health System
  - Flint, Michigan, United States, 48504
    - Aa Mrc, Llc
  - Lansing, Michigan, United States, 48912
    - Sparrow Clinical Research Institute | Sparrow Hospital - Clinical Research Department
- Minnesota
  - Maplewood, Minnesota, United States, 55109
    - M Health Fairview
  - Minneapolis, Minnesota, United States, 55417
    - Minneapolis VA Medical Center
  - Rochester, Minnesota, United States, 55905
    - Mayo Clinic - Rochester
  - Saint Paul, Minnesota, United States, 55102
    - Minneapolis Heart Institute
- Mississippi
  - Jackson, Mississippi, United States, 39216
    - Jackson Heart Clinic | Jackson, MS
  - Tupelo, Mississippi, United States, 38801
    - Cardiology Associates Research, LLC
- Missouri
  - Saint Louis, Missouri, United States, 63136
    - St. Louis Heart & Vascular, PC
- Nebraska
  - Grand Island, Nebraska, United States, 68803
    - Nebraska Heart Institute- Grand Island
- New Jersey
  - Bridgewater, New Jersey, United States, 08807
    - Advanced Heart Care, LLC | Bridgewater, NJ
  - Camden, New Jersey, United States, 08103
    - Cooper Specialty Care at Voorhees
  - Linden, New Jersey, United States, 07036
    - NJ Medcare/NJ Heart
  - Manalapan, New Jersey, United States, 07726
    - Garden State Heart Care
  - Mullica Hill, New Jersey, United States, 08062
    - Inspira Medical Centers | Clinical Research Office
  - Warren, New Jersey, United States, 07059
    - IMA Clinical Research | Warren, NJ
- New York
  - Middletown, New York, United States, 10941
    - Circuit Clinical/Crystal Run
  - New York, New York, United States, 10001
    - NYU Langone Health | NYU Langone Medical Associates Chelsea - Cardiovascular Research
  - Riverhead, New York, United States, 11901
    - Division of Cardiovascular Research at Peconic Bay Med Ctr
  - Westfield, New York, United States, 14787
    - Great Lakes Medical Research, LLC - New York
- North Carolina
  - Chapel Hill, North Carolina, United States, 27599-7065
    - University of North Carolina
  - Durham, North Carolina, United States, 27710
    - Duke University School of Medicine
  - Durham, North Carolina, United States, 27710
    - Duke Univ. Medical Center
  - Greensboro, North Carolina, United States, 27405
    - Medication Management, LLC
  - Mount Airy, North Carolina, United States, 27030
    - Clinical Trials of America, Inc.
- North Dakota
  - Fargo, North Dakota, United States, 58104
    - Lillestol Research, LLC
- Ohio
  - Canton, Ohio, United States, 44710
    - Aultman | Aultman Hospital Main Campus - Clinical Trials
  - Kettering, Ohio, United States, 45429
    - Kettering Health Network | Research Institute
  - Marion, Ohio, United States, 43302-6774
    - Rama Research LLC | Marion, OH
  - Toledo, Ohio, United States, 43615
    - Promedica Toledo Hospital
- Oklahoma
  - Oklahoma City, Oklahoma, United States, 73135
    - South Oklahoma Heart Research, LLC
- Oregon
  - Portland, Oregon, United States, 97239
    - Oregon Health and Science University
- Pennsylvania
  - Camp Hill, Pennsylvania, United States, 17011
    - Capital Area Research, LLC
  - Doylestown, Pennsylvania, United States, 18901
    - Doylestown Hospital
  - Hershey, Pennsylvania, United States, 17033
    - Pennsylvania State University College of Medicine
  - Philadelphia, Pennsylvania, United States, 19107
    - Thomas Jefferson University Hospitals
  - Wynnewood, Pennsylvania, United States, 19096
    - Main Line Health
  - Yardley, Pennsylvania, United States, 19067
    - Cardiology Consultants of Philadelphia-Yardley
- South Carolina
  - Anderson, South Carolina, United States, 29621
    - AnMed Clinical Research
  - Fort Mill, South Carolina, United States, 29707
    - Piedmont Research Partners LLC
  - Ladson, South Carolina, United States, 29456
    - Accellacare | Mt. Pleasant, South Carolina
- South Dakota
  - Rapid City, South Dakota, United States, 57701
    - Rapid City Regional Hospital
- Tennessee
  - Bristol, Tennessee, United States, 37620
    - Holston Medical Group - Bristol
  - Chattanooga, Tennessee, United States, 37403
    - Erlanger Health, Inc.
  - Germantown, Tennessee, United States, 38138
    - Stern Cardiovascular Center
  - Jackson, Tennessee, United States, 38301
    - Apex Cardiology, LLC
  - Nashville, Tennessee, United States, 37232
    - Vanderbilt University Medical Center
  - Powell, Tennessee, United States, 37849
    - Cardiovascular Research of Knoxville
- Texas
  - Amarillo, Texas, United States, 79109
    - PharmaTex Research, LLC
  - Dallas, Texas, United States, 75235
    - Southwest Family Medicine Associates
  - Denton, Texas, United States, 76201
    - Prime Revival Reserach Institute, LLC | Denton, TX
  - El Paso, Texas, United States, 79905
    - David Turbay MD PLLC
  - Fort Worth, Texas, United States, 76104
    - Texas Health Research & Education Institute
  - Fort Worth, Texas, United States, 76107
    - Texas Health Physicians Group - Fort Worth
  - Houston, Texas, United States, 77030
    - Houston Methodist Hospital
  - Kingwood, Texas, United States, 77339
    - TCR Institute
  - McKinney, Texas, United States, 75071
    - North Texas Research Associates
  - McKinney, Texas, United States, 75069-1780
    - North Dallas Research Associate | McKinney, TX
  - Plano, Texas, United States, 75093
    - Styde Research LLC | Plano, TX
  - San Antonio, Texas, United States, 78212
    - Clinical Advancement Center, PLLC
  - Sugar Land, Texas, United States, 77479
    - Mt. Olympus Medical Research
  - Tomball, Texas, United States, 77375
    - Northwest Houston Heart Center
  - Tyler, Texas, United States, 75702
    - Christus Trinity Mother Francis Health System
  - Tyler, Texas, United States, 75701
    - Tyler Cardiovascular Consultants | Tyler, TX
- Virginia
  - Fairfax, Virginia, United States, 22031
    - Inova Fairfax Hospital - Fairfax
  - Falls Church, Virginia, United States, 22042
    - Virginia Heart
  - Manassas, Virginia, United States, 20109
    - Carient Heart and Vascular
  - Norfolk, Virginia, United States, 23504
    - York Clinical Research
  - Richmond, Virginia, United States, 23298
    - Virginia Commonwealth University
  - Richmond, Virginia, United States, 23249
    - Hunter Holmes McGuire Veterans Affairs Medical Center
- Washington
  - Port Orchard, Washington, United States, 98366
    - Sound Medical Research
  - Wenatchee, Washington, United States, 98801
    - Confluence Health

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Description

Inclusion Criteria:

18 years of age or older (at legal age of consent according to local legislation) at the time of signing the informed consent
Atrial fibrillation documented by ECG evidence with an indication for indefinite treatment with an oral anticoagulant
CHA2DS2-VASc score ≥ 3 if male or ≥ 4 if female, OR CHA2DS2-VASc score of 2 if male or 3 if female and enrichment criteria.

Exclusion Criteria:

Mechanical heart valve prosthesis
Moderate-to-severe mitral stenosis at the time of inclusion into the study
Atrial fibrillation only due to reversible cause
Requirement for chronic anticoagulation for a different indication than AF

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Quadruple

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Asundexian Participants will receive asundexian and apixaban matching placebo.	Drug: Asundexian (BAY2433334) Once a day Drug: Apixaban matching placebo Placebo to apixaban, twice a day
Active Comparator: Apixaban Participants will receive apixaban and asundexian matching placebo.	Drug: Apixaban 5 mg or 2.5 mg, twice a day, according to product label. Drug: Asundexian matching placebo Placebo to asundexian, once a day

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to first occurrence of composite of stroke or systemic embolism Time Frame: Up to 34 months		Up to 34 months
Time to first occurrence of ISTH major bleeding Time Frame: Up to 34 months	ISTH = International Society on Thrombosis and Hemostasis	Up to 34 months
Time to first occurrence of composite of stroke, systemic embolism, or ISTH major bleeding Time Frame: Up to 34 months		Up to 34 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to first occurrence of composite of ischemic stroke or systemic embolism Time Frame: Up to 34 months		Up to 34 months
Time to first occurrence of all-cause mortality Time Frame: Up to 34 months		Up to 34 months
Time to first occurrence of ischemic stroke Time Frame: Up to 34 months		Up to 34 months
Time to first occurrence of CV death Time Frame: Up to 34 months	CV = cardiovascular	Up to 34 months
Time to first occurrence of composite of CV death, stroke, or myocardial infarction Time Frame: Up to 34 months		Up to 34 months
Time to first occurrence of composite of ISTH major or clinically relevant non-major bleeding Time Frame: Up to 34 months		Up to 34 months
Time to first occurrence of clinically relevant non-major bleeding Time Frame: Up to 34 months		Up to 34 months
Time to first occurrence of hemorrhagic stroke Time Frame: Up to 34 months		Up to 34 months
Time to first occurrence of intracranial hemorrhage Time Frame: Up to 34 months		Up to 34 months
Time to first occurrence of fatal bleeding Time Frame: Up to 34 months		Up to 34 months
Time to first occurrence of minor bleeding Time Frame: Up to 34 months		Up to 34 months
Time to first occurrence of composite of stroke, systemic embolism, ISTH major bleeding, or all-cause mortality Time Frame: Up to 34 months		Up to 34 months
Time to first occurrence of composite of disabling stroke (mRS ≥ 3), critical bleeding, or all-cause mortality Time Frame: Up to 34 months	mRS = modified Rankin Scale	Up to 34 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Bayer

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Click here to find further information and, after study completion, the study results according to Bayer's transparency standards

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 5, 2022

Primary Completion (Actual)

January 31, 2024

Study Completion (Actual)

January 31, 2024

Study Registration Dates

First Submitted

November 30, 2022

First Submitted That Met QC Criteria

November 30, 2022

First Posted (Actual)

December 8, 2022

Study Record Updates

Last Update Posted (Actual)

February 28, 2024

Last Update Submitted That Met QC Criteria

February 26, 2024

Last Verified

February 1, 2024

More Information

Terms related to this study

Other Study ID Numbers

19767
2022-000758-28 (EudraCT Number)
2023-503794-38-00 (Other Identifier: CTIS (EU))

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

Availability of this study's data will later be determined according to Bayer's commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, timepoint and process of data access. As such, Bayer commits to sharing upon request from qualified researchers patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, 2014.

Interested researchers can use www.vivli.org to request access to anonymized patient-level data and supporting documents from clinical studies to conduct research. Information on the Bayer criteria for listing studies and other relevant information is provided in the member section of the portal.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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AtriCure, Inc.

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Maastricht University Medical Center
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Unknown

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Enrolling by invitation

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St. George's Hospital, London

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Hybrid AbLaTion of Atrial Fibrillation (HALT-AF)

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R-Pharm
FSBI "National Medical Research Center of Cardiology named after academician...

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Recruiting

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United States, Switzerland, Belgium, Sweden, Canada, Australia, Taiwan, Spain, Korea, Republic of, Latvia, Israel, Malaysia, Greece, Japan, Turkey, Netherlands, Romania, China, United Kingdom, Portugal, Italy, Brazil, France, Slovakia, ... and more
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Completed

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Completed

Study to Gather Information About the Proper Dosing and Safety of the Oral FXIa Inhibitor BAY 2433334 in Patients Following an Acute Heart Attack (PACIFIC-AMI)

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Spain, Japan, Belgium, United States, Czechia, Hungary, Switzerland, Netherlands, Germany, Austria, Poland, Italy, Sweden, United Kingdom
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Completed

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Spain, Japan, Australia, Czechia, Sweden, United Kingdom, Netherlands, Belgium, Russian Federation, Hungary, Slovakia, China, Germany, Switzerland, France, Poland, Denmark, United States, Austria, Bulgaria, Finland, Italy, Portugal
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Atrial Fibrillation (AF)

Spain, Belgium, Latvia, Italy, Switzerland, Canada, Austria, Japan, Czechia, Hungary, Netherlands, Sweden, France, United Kingdom

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Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Publications and helpful links

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Actual)

Study Completion (Actual)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Atrial Fibrillation

Clinical Trials on Asundexian (BAY2433334)

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