Effects of Aerobic Training Program On Liver Functions

January 19, 2023 updated by: Masood Khan, King Saud University

Effects of an Aerobic Training Program on Liver Functions in Male Athletes - a Randomized Controlled Trial

The liver plays a central role in energy exchange, protein synthesis as well as the elimination of waste products from the body. The optimal functioning of the liver is essential for athletic performance. It becomes necessary to maintain the enzymes of the liver at an optimal level so that liver cells can be protected from inflammation or damage. This paper investigated the effects of a twelve-week aerobic exercise program on the liver function of adult athletes. A total of thirty (30) healthy male athletes aged 21 to 24 were recruited for this study and kept in two equal groups. The control group was kept under rigorous supervision and did not participate in any special activities. The experiment group was well-versed in their assigned training program and solely performed the experimental procedure for twelve (12) weeks. Evaluation of all patients in both experimental and control groups was carried out before and after the treatment program by measuring the levels of (Alkaline phosphate, AST/SGOT, ALT/SGPT, Bilirubin Total/indirect/direct, Albumin, Globulin, and Total protein) respectively using standard methods by collecting blood samples, 5 mls each of baseline into lithium heparin containers for estimation of above biochemical parameters at the pathology laboratory accredited by National Accreditation Board for Testing and Calibration Laboratories accredited (NABL, India).

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Saudi Arabia
      • Riyadh, Saudi Arabia, 11433
        • King Saud University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

21 years to 24 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • Male
  • Age: 21-24 years
  • Healthy
  • Athletes

Exclusion Criteria:

  • history of severe illness,
  • surgery, or damage to liver,
  • fatty liver disease,
  • cirrhosis,
  • blood infections,
  • neuromuscular illnesses,
  • or the presence of any disorders such as fever, high blood pressure, high blood sugar

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Experimental Group
Aerobic training program was performed by participants.
Other: Aerobic training
Exercises on a treadmill at different speeds and inclination were performed.
No Intervention: Control group
No intervention was performed by the participants.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Bilirubin-Total
Time Frame: 12 weeks.
Blood level of Bilirubin-Total was measured.
12 weeks.
Serum aspartate aminotransferase/serum glutamic-oxaloacetic transaminase (AST/SGOT)
Time Frame: 12 weeks.
Blood level of Serum AST/SGOT was measured.
12 weeks.
Serum alanine transaminase/Serum Glutamic Pyruvic Transaminase (ALT/SGPT)
Time Frame: 12 weeks.
Blood level of Serum ALT/SGPT was measured.
12 weeks.
Alkaline Phosphatase
Time Frame: 12 weeks.
Blood level of Alkaline Phosphatase was measured.
12 weeks.
Protein-Total
Time Frame: 12 weeks.
Blood level of Protein-Total was measured.
12 weeks.
Albumin
Time Frame: 12 weeks.
Blood level of Albumin was measured.
12 weeks.
Globulin
Time Frame: 12 weeks.
Blood level of Globulin was measured.
12 weeks.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

King Saud University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 1, 2021

Primary Completion (Actual)

July 14, 2022

Study Completion (Actual)

November 30, 2022

Study Registration Dates

First Submitted

January 19, 2023

First Submitted That Met QC Criteria

January 19, 2023

First Posted (Estimate)

January 30, 2023

Study Record Updates

Last Update Posted (Estimate)

January 30, 2023

Last Update Submitted That Met QC Criteria

January 19, 2023

Last Verified

January 1, 2023

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • DN 4900 /FSS

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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