A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation (LIBREXIA-AF)

May 7, 2026 updated by: Janssen Research & Development, LLC

A Phase 3, Randomized, Double-Blind, Double-Dummy, Parallel Group, Active-Controlled Study to Evaluate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, Versus Apixaban in Participants With Atrial Fibrillation

The purpose of this study is to evaluate if milvexian is at least as effective as apixaban for reducing the risk of the composite stroke and non-central nervous system (CNS) systemic embolism.

Study Overview

Status

Active, not recruiting

Conditions

Atrial Fibrillation

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

20284

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Argentina
- - Bahía Blanca, Argentina, A8000FTD
    - Instituto de Investigaciones Clínicas Bahia Blanca
  - Buenos Aires, Argentina, C1440CFD
    - CEMEDIC
  - Buenos Aires, Argentina, C1187AAN
    - Sanatorio Finochietto
  - Buenos Aires, Argentina, C1199
    - Hospital Italiano de Buenos Aires
  - Buenos Aires, Argentina, C1061AAS
    - CIPREC
  - Buenos Aires, Argentina, 1060
    - CEDIC Centro de Investigaciones Clinicas
  - CABA, Argentina, C1056ABJ
    - CINME Centro de Investigaciones Metabolicas
  - Capital Federal, Argentina, C1118AAE
    - Clínica y Maternidad Suizo Argentina
  - Ciudad Autonoma Buenos Aires, Argentina, C1093AAS
    - Fundacion Favaloro
  - Ciudad Autonoma Buenos Aires, Argentina, 1406
    - Consultorio Dr. Litvak Bruno
  - Ciudad Autonoma Buenos Aires, Argentina, 1428
    - Instituto Cardiovascular de Buenos Aires
  - Ciudad Autonoma Buenos Aires, Argentina, 1425
    - Consultorios Asociados de Endocrinología e Investigación Clínica Aplicada
  - Ciudad Autonoma Buenos Aires, Argentina, C1430CKE
    - Glenny Corp. S.A. - Bioclinica Argentina
  - Ciudad de Buenos Aires, Argentina, C1430EGF
    - Clinica Adventista Belgrano
  - Ciudadela, Argentina, 1702
    - Instituto Médico Elsa Pérez I.M.E.P
  - Cordooba, Argentina, X5003DCP
    - Centro Médico Colón
  - Coronel Suárez, Argentina, B7540GHD
    - Clinica Coronel Suárez
  - Córdoba, Argentina, X5000JHQ
    - Sanatorio Allende
  - Córdoba, Argentina, X5004BAL
    - Hospital Italiano de Córdoba
  - Córdoba, Argentina, 5000
    - Hospital San Roque
  - Córdoba, Argentina, X5003DCE
    - Instituto Medico Damic
  - Córdoba, Argentina, X5000AVE
    - CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani
  - Córdoba, Argentina, 5000
    - Clinica Privada Velez Sarsfield
  - Córdoba, Argentina, X5000AAW
    - Instituto de Investigaciones Clínicas Córdoba
  - Córdoba, Argentina, X5006IKK
    - Centro Medico Luquez
  - Córdoba, Argentina, 5000
    - Clínica Colombo
  - Córdoba, Argentina, X5002HWE
    - Instituto Privado De Especialidades Medicas S.A. Fundacion J Robert Cade
  - Córdoba, Argentina, X5004CDT
    - Hospital Cordoba
  - Godoy Cruz, Argentina, 5501
    - CIPADi
  - Junín, Argentina, B6000BHA
    - Centro Medico Lebensohn
  - Mar del Plata, Argentina, B7600FZN
    - Instituto de Investigaciones Clinicas Mar del Plata
  - Mar del Plata, Argentina, B7600FYK
    - Centro de Investigaciones Medicas Mar del Plata
  - Mendoza, Argentina, 5500
    - Fundacion Scherbovsky
  - Quilmes, Argentina, B1878GEG
    - Instituto de Investigaciones Clinicas Quilmes
  - Ramos Mejía, Argentina, B1704ETD
    - Dim Clinica Privada
  - Rosario, Argentina, S2000SDV
    - Sanatorio Parque
  - Rosario, Argentina, 2000
    - Sanatorio Britanico S.A.
  - Rosario, Argentina, 2000
    - Sanatorio de la Mujer
  - Rosario, Argentina, S2000BIF
    - Instituto de Investigaciones Clinicas de Rosario
  - Salta, Argentina, 4406
    - Centro Cardiovascular Salta
  - Salta, Argentina, 4400
    - Centro de Investigaciones Clinicas Salta
  - San Juan, Argentina, 5400
    - Investigaciones Clinicas Cuyo
  - San Miguel de Tucumán, Argentina, T4000ICL
    - Investigaciones Clinicas Tucuman
  - San Nicolás, Argentina, B2900DMH
    - Instituto de Investigaciones Clinicas San Nicolás
  - Santa Fe, Argentina, 3000
    - Centro de Investigaciones Clinicas del Litoral
  - Santa Fe, Argentina, S3000EOZ
    - Hospital Provincial Dr. José María Cullen
  - Temperley, Argentina, B1834GUK
    - Centro de Investigaciones Medicas Temperley
  - Venado Tuerto, Argentina, S2600KUE
    - Sanatorio San Martin
  - Villa María, Argentina, X5900JKA
    - Clinica Privada Fusavim SRL
  - Zárate, Argentina, 2800
    - Instituto de Investigaciones Clinicas Zarate
Australia
- - Adelaide, Australia, 5042
    - Flinders Medical Centre
  - Brisbane, Australia, 4066
    - Advara HeartCare Wesley
  - Concord, Australia, 2139
    - Concord Repatriation General Hospital
  - Frankston, Australia, 3199
    - Peninsula Heart Center
  - Garran, Australia, 2605
    - The Canberra Hospital
  - Herston, Australia, 4029
    - Royal Brisbane and Women's Hospital
  - Joondalup, Australia, 6027
    - GenesisCare Joondalup-Shenton House
  - Kotara, Australia, 2289
    - Novatrials
  - Leabrook, Australia, 5068
    - GenesisCare
  - Liverpool, Australia, 2170
    - Liverpool Hospital
  - Milton, Australia, 4064
    - Core Research Group
  - Taringa, Australia, 4068
    - AusTrials Tarragindi
Belgium
- - Aalst, Belgium, 9300
    - Algemeen Stedelijk Ziekenhuis
  - Antwerp, Belgium, 2020
    - ZNA Middelheim
  - Arlon, Belgium, 6700
    - CSL Arlon
  - Brussels, Belgium, 1070
    - CUB Hôpital Erasme
  - Brussels, Belgium, 1020
    - C.H.U. Brugmann
  - Dendermonde, Belgium, 9200
    - AZ Sint-Blasius
  - Edegem, Belgium, 2650
    - UZA
  - Herk-de-Stad, Belgium, 3540
    - Jessa Ziekenhuis - Campus St.-Ursula
  - La Louvière, Belgium, 7100
    - CHU Tivoli
  - Leuven, Belgium, 3000
    - UZ Leuven
  - Mechelen, Belgium, 97770
    - Az Sint-Maarten
  - Mol, Belgium, 2400
    - Heilig Hart Ziekenhuis Lier
  - Roeselare, Belgium, 8800
    - AZ Delta vzw
  - Turnhout, Belgium, 2900
    - Az Turnhout
Brazil
- - Belo Horizonte, Brazil, 30150-240
    - Cardresearch - Cardiologia Assistencial
  - Belo Horizonte, Brazil, 30140-062
    - Hospital Vera Cruz
  - Belo Horizonte, Brazil, 30110-934
    - Hospital Felicio Rocho
  - Botucatu, Brazil, 18618-686
    - Fundacao para o Desenvolvimento Medico Hospitalar (UNESP Botucatu)
  - Brasília, Brazil, 70390-700
    - Rede D or Sao Luiz S A Hospital do Coracao do Brasil
  - Brasília, Brazil, 70710 149
    - Centro de Cardiologia Clinica e Pesquisa Doutora Juliana Souza Ltda CECAP Centro de Cardiologia Clinica
  - Campina Grande do Sul, Brazil, 83430-000
    - Sociedade Hospitalar Angelina Caron
  - Campinas, Brazil, 13060-080
    - Instituto de Pesquisa clinica de Campinas
  - Campinas, Brazil, 13010-001
    - C.E.C.-Centro Especializado em Cardiologia Ltda.- Loema Medicina e Bem Estar
  - Canoas, Brazil, 92425-900
    - Hospital Universitario
  - Criciúma, Brazil, 88811-508
    - Sociedade Literaria e Caritativa Santo Agostinho Hospital Sao Jose
  - Curitiba, Brazil, 80320-320
    - Hospital Cardiológico Costantini
  - Curitiba, Brazil, 80010-030
    - Irmandade Santa Casa de Misericórdia de Curitiba -Pontifícia Universidade Católica do Paraná-PUCPR
  - Curitiba, Brazil, 80730-150
    - Nucleo de Pesquisa Clinica
  - Goiânia, Brazil, 74605-020
    - Universidade Federal de Goias - Hospital das Clinicas da UFG
  - Marília, Brazil, 17515-000
    - Instituto do Coracao de Marilia
  - Marília, Brazil, 17515-000
    - Irmandade da Santa Casa de Misericórdia de Marília
  - Natal, Brazil, 59020-035
    - Hemocardio SS Ltda
  - Passo Fundo, Brazil, 99010-120
    - Instituto Mederi de Pesquisa e Saude
  - Pelotas, Brazil, 96015 290
    - Santa Casa de Misericordia de Pelotas
  - Porto Alegre, Brazil, 90035-903
    - Hospital das Clinicas de Porto Alegre
  - Porto Alegre, Brazil, 90035-001
    - Associacao Hospitalar Moinhos de Vento
  - Porto Alegre, Brazil, 90160-092
    - Hospital Ernesto Dornelles
  - Porto Alegre, Brazil, 90620-001
    - Fundacao Universitaria de Cardiologia
  - Porto Alegre, Brazil, 90020 090
    - Irmandade Da Santa Casa de Misericórdia de Porto Alegre
  - Porto Alegre, Brazil, 90110-270
    - IMV Pesquisa Cardiologica Sociedade Simples HMD COR l
  - Recife, Brazil, 50100-060
    - Pro Cardiaco Pronto Socorro Cardiologico
  - Recife, Brazil, 52051-380
    - Secretaria de Saude Hospital Agamenon Magalhaes
  - Ribeirão Preto, Brazil, 14098-900
    - Hospital Das Clinicas Da Faculdade De Medicina De RPUSP HCRP
  - Rio de Janeiro, Brazil, 22061-080
    - Impar Servicos Hospitalares S/A
  - Salvador, Brazil, 41810-010
    - Fundacao Bahiana de Cardiologia
  - Salvador, Brazil, 40170-130
    - Instituto CardioPulmonar
  - Santo André, Brazil, 09080-110
    - Pesquisare Saude
  - São José, Brazil, 88103-460
    - Instituto de Cardiologia de Santa Catarina
  - São José do Rio Preto, Brazil, 15090-000
    - Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto Hospital de Base
  - São Paulo, Brazil, 05403-000
    - Hospital das Clinicas da Faculdade de Medicina da USP
  - São Paulo, Brazil, 04012-909
    - Instituto Dante Pazzanese de Cardiologia
  - São Paulo, Brazil, 01323-903
    - Hospital Alemao Oswaldo Cruz
  - São Paulo, Brazil, 01221-020
    - Irmandade Santa Casa de Misericordia de Sao Paulo
  - São Paulo, Brazil, 01323 000
    - FGM Clinica Paulista de Doencas Cardiovasculares Ltda IPDC Cardiologia
  - Tatuí, Brazil, 18270-170
    - Instituto de Moléstias Cardiovasculares Tatuí
  - Uberaba, Brazil
    - HC-UFTM - Hospital de Clínicas da Universidade Federal do Triângulo Mineiro
  - Vitória, Brazil, 29702-020
    - Clinica Cardioped Ltda
  - Vitória, Brazil, Espírito Santo
    - CEDOES
  - Votuporanga, Brazil, 15500-003
    - Santa Casa de Misericórdia de Votuporanga
Bulgaria
- - Blagoevgrad, Bulgaria, 2700
    - MHAT Puls
  - Burgas, Bulgaria
    - MC 4Life Ltd
  - Dimitrovgrad, Bulgaria, 6400
    - Medical Center Diamedical
  - Dimitrovgrad, Bulgaria, 6400
    - MHAT St. Ekaterina
  - Dupnitsa, Bulgaria, 2600
    - Medical Centre Asklepii OOD
  - Gabrovo, Bulgaria, 5300
    - Multiprofile Hospital for Active Treatment Dr. Tota Venkova
  - Haskovo, Bulgaria, 6300
    - Multiprofile Hospital for Active Treatment - Haskovo
  - Kardzhali, Bulgaria, 6600
    - Medical Center Rodopimed EOOD
  - Pazardzhik, Bulgaria, 44000
    - UMHAT 'Pulmed' OOD- MS 'Zdrave' - Pazardzhik
  - Pleven, Bulgaria, 5800
    - UMHAT 'Dr. Georgi Stranski', EAD
  - Pleven, Bulgaria, 5800
    - Medical Center Medconsult-Pleven
  - Pleven, Bulgaria, 5800
    - UMHAT 'Heart and Brain Center for Excellence'
  - Pleven, Bulgaria, 5300
    - Exacta Medica
  - Plovdiv, Bulgaria, 4000
    - UMHAT 'Sv. Georgi' EAD
  - Rousse, Bulgaria, 7000
    - Medical Center- Prolet Ltd
  - Rousse, Bulgaria, 7013
    - MC Rusemed ltd
  - Sevlievo, Bulgaria, 5402
    - Medical Center Unimed Eood
  - Sofia, Bulgaria, 1510
    - Medical Center Hera EOOD
  - Sofia, Bulgaria, 1309
    - Multiprofile Hospital For Active Treatment National Cardiology Hospital, Ead
  - Sofia, Bulgaria, 1407
    - Acibadem City Clinic Tokuda Hospital
  - Sofia, Bulgaria, 1750
    - University Multiprofile Hospital for Active Treatment- UMHAT Sveta Anna AD
  - Sofia, Bulgaria, 1680
    - DCC Convex EOOD
  - Sofia, Bulgaria, 1431
    - Diagnostic Consultation Centre 'Alexandrovska' EOOD
  - Sofia, Bulgaria, 1233
    - National Multiprofile Transport Hospital Tsar Boris III
  - Sofia, Bulgaria, 1527
    - University Multiprofile Hospital for Active Treatment - Tsaritsa Yoanna - ISUL, EAD
  - Sofia, Bulgaria, 1431
    - UMHAT Prof. Dr. Aleksandar Chirkov
  - Sofia, Bulgaria, 1000
    - Individual Ambulatory of Cardiology
  - Sofia, Bulgaria, 1202
    - DCC Ascendent EAD
  - Sofia, Bulgaria, 1202
    - Second Multiprofile Hospital for Active Treatment MHAT - Sofia AD
  - Sofia, Bulgaria, 1233
    - MHAT Knyaginya Klementina
  - Sofia, Bulgaria, 1612
    - Meditsinski Centar - Izgrev Eood
  - Sofia, Bulgaria, 1680
    - Medical Centre Kalimat
  - Sofia, Bulgaria, 1431
    - Diagnostic Consultation Centre Alexandrovska EOOD 1
  - Stara Zagora, Bulgaria, 6003
    - UMHAT Prof. Dr. St. Kirkovich AD
  - Stara Zagora, Bulgaria, 6003
    - Medical Center ZaraMed
  - Varna, Bulgaria, 9000
    - DCC Chaika EOOD
  - Veliko Tarnovo, Bulgaria, 5000
    - MHAT Dr Stefan Cherkezov
  - Veliko Tarnovo, Bulgaria, 5000
    - Medical Center -Medika Plus
  - Yambol, Bulgaria, 8600
    - MHAT Sv. Panteleymon AD
Canada
- Alberta
  - Calgery, Alberta, Canada, T2N 1N4
    - The Governers of the University of Calgary
  - Edmonton, Alberta, Canada, T6K 4C1
    - Alberta Health Services
- British Columbia
  - New Westminster, British Columbia, Canada, V3L 3W4
    - Fraser Clinical Trials Inc.
  - Surrey, British Columbia, Canada, V3V 0C6
    - Surrey Memorial Hospital
  - Victoria, British Columbia, Canada, V8R 4R2
    - Victoria Cardiac Arrhythmia Trials Inc
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 1V7
    - Queen Elizabeth II Health Sciences Centre
- Ontario
  - Brampton, Ontario, Canada, L6Z 4N5
    - Brampton Research Assoc
  - Cambridge, Ontario, Canada, N1R 7R1
    - Dr. Saul Vizel Cardiac Research Office
  - Mississauga, Ontario, Canada, L4Y 1M3
    - One Heart Care
  - Oshawa, Ontario, Canada, L1J 2K1
    - Dr. James Cha
  - Peterborough, Ontario, Canada, K9J 0B2
    - Kawartha Cardiology Clinical Trials
  - Waterloo, Ontario, Canada, N2T 0C1
    - CPS Research
- Quebec
  - Greenfield Park, Quebec, Canada, J4V 2G8
    - ViaCar Recherche Clinique Inc
  - Montreal, Quebec, Canada, H3G 1A4
    - Montreal General Hospital
  - Montreal, Quebec, Canada, H2X 0C1
    - CHUM - Pavillon B
  - Québec, Quebec, Canada, 00
    - Montreal Heart Institute
Chile
- - Puerto Varas, Chile, 5551070
    - Quantum Research
  - Santiago, Chile, 7500710
    - Biomedica Research Group
  - Santiago, Chile, 8331143
    - CeCim - Centro de Estudios Clinicos e Investigacion Medica
  - Santiago, Chile, 7500000
    - Enroll SpA
  - Santiago, Chile, 7500739
    - SMOLAM
  - Santiago, Chile
    - Sociedad Medica Cardiologica El Llano
  - Santiago, Chile, 8330024
    - Centro de Investigacion Clinica Universidad Catolica de Chile CICUC
  - Temuco, Chile, 4780000
    - Centro de Estudios Cardiologicos y de Medicina Interna
  - Temuco, Chile, 4781156
    - Centro de Investigacion Clinica del Sur
  - Viña del Mar, Chile, 2520997
    - Centro de Estudios Clinicos V Region Ltda
China
- - Beijing, China, 100853
    - Chinese PLA General Hospital
  - Beijing, China, 100191
    - Peking University Third Hospital
  - Beijing, China, 100029
    - Beijing Anzhen Hospital, Capital Medical University
  - Cangzhou, China, 61000
    - Cangzhou People's Hospital
  - Changchun, China, 130021
    - The First Hospital of Jilin University
  - Changchun, China, 130021
    - Jilin Province Peoples Hospital
  - Changsha, China, 410013
    - The third xiangya hospital of Central South University
  - Changsha, China, 410015
    - The Third Hospital of Changsha
  - Changzhou, China, 213004
    - Changzhou No 2 Peoples Hospital
  - Chengdu, China, 610041
    - West China Hospital Sichuan University
  - Chengdu, China, 610072
    - Sichuan Provincial Peoples Hospital
  - Chongqing, China, 400014
    - Chongqing General Hospital
  - Daqing, China, 163311
    - Heilongjiang Daqing People's Hospital
  - Dongguan, China, 523059
    - Dongguan People s Hospital
  - Fuzhou, China, 350005
    - The First Affiliated Hospital of Fujian Medical University
  - Ganzhou, China, 341000
    - Jiangxi Ganzhou Peoples Hospital
  - Guangzhou, China, 510080
    - Guangdong Provincial People's Hospital
  - Guangzhou, China, 510280
    - ZhuJiang Hospital of Southern Medical University
  - Guangzhou, China, 510080
    - The First Affiliated Hospital of Sun Yat-sen University
  - Guangzhou, China, 510630
    - The Third Affiliated Hospital Sun Yat sen University
  - Guiyang, China, 550000
    - The Affiliated Hospital of Guizhou Medical University
  - Guiyang, China, 550002
    - GuiZhou Privicial Peoples Hospital
  - Haikou, China, 570102
    - Affiliated Hospital of Hainan Medical University
  - Hangzhou, China, 310006
    - Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine
  - Hefei, China, 230601
    - The Second Hospital of Anhui Medical University
  - Hefei, China, 230001
    - Anhui Province Hospital
  - Hohhot, China, 010017
    - Inner Mongolia People's Hospital
  - Jieyang, China, 522091
    - Jieyang Peoples Hospital
  - Jinan, China, 250012
    - Qilu Hospital of Shandong University
  - Jining, China, 272011
    - Shandong Jining No.1 People's Hospital
  - Lanzhou, China, 730030
    - Lanzhou University Second Hospital
  - Luoyang, China, 471002
    - Luoyang Third People's Hospital
  - Nanchang, China, 330006
    - The Second Affiliated Hospital of Nanchang University
  - Nanchang, China, 330006
    - Jiangxi Provincial Peoples Hospital
  - Nanchang, China, 330009
    - Nanchang Peoples hospital
  - Ningbo, China, 315010
    - Ningbo First Hospital
  - Shanghai, China, 200032
    - Zhongshan Hospital Fudan University
  - Shanghai, China, 200011
    - Shanghai Ninth Peoples Hospital
  - Shanghai, China, 201508
    - Jinshan Hospital Fudan University
  - Shantou, China, 515041
    - The First Affiliated Hospital of Shantou University Medical
  - Shenyang, China, 110004
    - Shengjing Hospital of China Medical University
  - Shenzhen, China, 518052
    - Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen
  - Shijiazhuang, China, 050000
    - The Second Hospital of Hebei Medical University
  - Suzhou, China, 215006
    - The First Affiliated Hospital of Soochow University
  - Taian, China, 271000
    - Taian City Central Hospital
  - Taiyuan, China, 030013
    - Shanxi Cardiovascular Hospital
  - Taizhou, China, 318020
    - Taizhou First Peoples Hospital
  - Tianjin, China, 300052
    - Tianjin Medical University General Hospital
  - Tianjin, China, 300457
    - Teda International Cardiovascular Hospital
  - Tianjin, China, 300121
    - Tianjin People's Hospital
  - Tianjin, China, 300051
    - Tianjin Chest Hospital
  - Tianjin, China, 300140
    - Tianjin 4th Center Hospital
  - Tianjin, China, 300211
    - The 2nd Hospital of Tianjin Medical University
  - Wenzhou, China, 325000
    - The First Affiliated Hospital of Wenzhou Medical University
  - Wenzhou, China, 325000
    - Wenzhou Peoples Hospital
  - Wuhan, China, 430014
    - The Central Hospital of Wuhan
  - Wuhan, China, 430060
    - Union Hospital Tongji Medical College of Huazhong University of Science and Technology
  - Xi'an, China, 710068
    - Shaanxi Provincial Peoples Hospital
  - Xinxiang, China, 453003
    - The Third Affiliated Hospital Of Xinxiang Medical University
  - Xuzhou, China
    - The Affiliated Hospital of Xuzhou Medical College
  - Yangzhou, China, 225001
    - Northern Jiangsu Peoples Hospital
  - Yantai, China, 264000
    - Yantai Yuhuangding Hospital
  - Yinchuan, China, 750004
    - General Hospital of Ningxia Medical Hospital
  - Zhanjiang, China, 524001
    - Affiliated Hospital of Guangdong Medical University
  - Zhengzhou, China, 450016
    - The 7th Peoples Hospital of Zhengzhou
  - Zunyi, China, 563099
    - Affiliated Hospital of Zunyi Medical University
Croatia
- - Dubrovnik, Croatia, 20000
    - General Hospital Dubrovnik
  - Karlovac, Croatia, 47000
    - Opca bolnica Karlovac
  - Krapinske Toplice, Croatia, 49217
    - Special Hospital for medical rehabilitation
  - Krapinske Toplice, Croatia, 49217
    - Clinic for Cardiovascular Disease Magdalena
  - Varaždin, Croatia, 42000
    - OB Varazdin
  - Varaždin, Croatia, 42000
    - OB Varazdin 1
  - Zadar, Croatia, 23000
    - Zadar General Hospital
  - Zagreb, Croatia, 10000
    - University Hospital Dubrava
  - Zagreb, Croatia, 10000
    - Polyclinic Bonifarm
  - Zagreb, Croatia, 10000
    - Poliklinika Solmed
  - Čakovec, Croatia, 40000
    - Zupanijska bolnica Cakovec
Czechia
- - Brandýs nad Labem, Czechia, 250 01
    - Medicus Services s.r.o.
  - Brandýs nad Labem, Czechia, 25001
    - Interni ordinace s.r.o
  - Brno, Czechia, 636 00
    - Vojenska nemocnice Brno
  - Brno, Czechia, 65691
    - Fakultni nemocnice u sv. Anny v Brne
  - Broumov, Czechia, 550 01
    - Edumed s.r.o.
  - Bílovec, Czechia, 743 01
    - HUMANITAS spol. s r.o.
  - Chomutov, Czechia, 430 02
    - Ordinace pro choroby srdce s.r.o.
  - Chrudim, Czechia, 537 01
    - MUDr. Jan Hubac s.r.o.
  - Jablonec nad Nisou, Czechia, 46601
    - Kardiologie KarMa s.r.o
  - Kroměříž, Czechia, 767 01
    - Lunacor s.r.o. - Ambulance kardiologie Centrum pro choroby srdce a cev
  - Litovel, Czechia, 78401
    - Kardio Interna s.r.o.
  - Olomouc, Czechia, 77900
    - Fakultni nemocnice Olomouc
  - Olomouc, Czechia, 77900
    - PreventaMed, s.r.o.
  - Olomouc, Czechia, 779 00
    - MUDr. Zdenek Vomacka kardiologie a interna s.r.o.
  - Ostrava Poruba, Czechia, 708 52
    - Cerebrovaskularni poradna s.r.o.
  - Pardubice, Czechia, 530 03
    - Pardubicka krajska nemocnice a s
  - Pilsen, Czechia, 304 60
    - Fakultni nemocnice Plzen
  - Prague, Czechia, 100 34
    - Fakultni nemocnice Kralovske Vinohrady
  - Prague, Czechia, 128 00
    - Vseobecna fakultni nemocnice v Praze
  - Prague, Czechia, 150 06
    - Fakultni nemocnice v Motole
  - Prague, Czechia, 158 00
    - MUDr. Eva Zídkova
  - Prague, Czechia, 101 00
    - MUDr. Jan KVASNICKA CSc. Angiologie kardiologie a interna
  - Prague, Czechia, 110 00
    - Nemocnice Na Frantisku
  - Prague, Czechia, 16902
    - Ustredni vojenske nemocnice Praha
  - Příbram, Czechia, 26101
    - Centrum klinickeho vyzkumu
  - Slaný, Czechia, 274 01
    - Nemocnice Slany, interni oddeleni
  - Trutnov, Czechia, 541 01
    - Interni ambulance
  - Uherské Hradiště, Czechia, 68601
    - Interni ambulance Dr.Stanislav Zemek
  - Zlín, Czechia, 760 01
    - Cardio Research s r o
  - České Budějovice, Czechia, 37001
    - Nemocnice Ceske Budejovice a s
Denmark
- - Aarhus, Denmark, 8200
    - Aarhus University Hospital
  - Copenhagen S, Denmark, 2300
    - Amager Hospital
  - Herlev, Denmark, 2730
    - Gentofte Herlev Hospital
  - Herning, Denmark, 7400
    - Herning Regional Hospital
  - Holbæk, Denmark, 4300
    - Holbæk Sygehus
  - Hvidovre, Denmark, 2650
    - Hvidovre Hospital
  - Køge, Denmark, 4600
    - Køge Sygehus Region Sjaelland
  - Slagelse, Denmark, 4200
    - Slagelse Sygehus
  - Svendborg, Denmark, 5700
    - Odense University Hospital
Estonia
- - Tallinn, Estonia, 13419
    - Dr. Arvo Rosenthal LLC
France
- - Angers, France, 49933
    - Chu Angers - Hôpital Hôtel Dieu
  - Bayonne, France, 64109
    - Centre Hospitalier de la Cote Basque
  - Brest, France, 29200
    - CHU de Brest - Hôpital de la Cavale Blanche
  - Bron, France, 69677
    - GH est - Hôpital Cardiovasculaire et Pneumologie Louis Pradel
  - Béziers, France, 34525
    - Centre Hospitalier de Beziers
  - Corbeil-Essonnes, France, 91106
    - Centre Hospitalier Sud Francilien
  - Créteil, France, 94010
    - Hôpital Henri Mondor
  - Dijon, France, 21033
    - Chu Dijon
  - Le Chesnay, France, 78157
    - Hopital Andre Mignot
  - Limoges, France, 87000
    - CHU de Limoges Hopital Dupuytren
  - Marseille, France, 13385
    - CHU de la Timone
  - Montauban, France, 82000
    - Clinique du Pont de Chaume
  - Nice, France, 06002
    - Centre Hospitalier Universitaire - de Nice - Hopital Pasteur
  - Paris, France, 75018
    - Hôpital Bichat - Claude Bernard
  - Paris, France, 75014
    - Hopital Saint Joseph
  - Paris, France, 75010
    - Hôpital Lariboisière
  - Paris, France, 75679
    - Hôpital Cochin
  - Paris, France, 75013
    - Hopital BROCA
  - Paris, France, 75571
    - Hôpital Saint-Antoine
  - Pau, France, 64000
    - Centre Hospitalier De Pau
  - Pessac, France, 33604
    - Groupe Hospitalier Sud - Hôpital Xavier Arnozan
  - Poitiers, France, 86000
    - CHU Poitiers - Hôpital la Milétrie
  - Rouen, France, 78000
    - Clinique Saint-Hilaire - Centre Frédéric Joliot
  - Rouen, France, 76031
    - CHU Rouen Hopital Charles Nicolle
  - Valenciennes, France, 59300
    - Polyclinique Vauban
Germany
- - Altenburg, Germany, 04600
    - Klinikum Altenburger Land GmbH
  - Bad Friedrichshall, Germany, 74177
    - Klinikum am Plattenwald
  - Bad Homburg, Germany, 61348
    - Kardiologische Praxis Dr. med. univ. Jungmair
  - Bad Oeynhausen, Germany, 32503
    - Ruhr Universitat Bochum Diabeteszentrum
  - Bamberg, Germany, 96049
    - Dres. Haas Kirschner Wagner
  - Berlin, Germany, 10249
    - Vivantes Klinikum im Friedrichshain
  - Berlin, Germany, 13509
    - Vivantes Humboldt Klinikum
  - Berlin, Germany, 12200
    - Charite Campus Benjamin Franklin
  - Berlin, Germany, 10559
    - Augentagesklinik Spreebogen Berlin GbR
  - Berlin, Germany, 10967
    - Vivantes Klinikum Am Urban, Abt. fur Kardiologie
  - Berlin, Germany, 12621
    - Vivantes Klinikum Hellersdorf
  - Beuel, Germany, 53225
    - GFO Kliniken Bonn, Betriebsstaette St. Marien
  - Bielefeld, Germany, 33604
    - Klinikum Bielefeld
  - Coburg, Germany, 96450
    - Regiomed Klinikum Coburg
  - Dachau, Germany, 85221
    - Medizinisches Versorgungszentrum (MVZ) Dachau
  - Deggingen, Germany, 73326
    - Gemeinschaftspraxis
  - Dessau, Germany, 06846
    - Praxis-Dr. Frank Menzel
  - Dresden, Germany, 01067
    - Städtisches Klinikum Dresden
  - Dresden, Germany, 01099
    - FAZ Dresden-Neustadt GbR
  - Dresden, Germany, 01277
    - Hausärztlich-Kardiologisches MVZ Am Felsenkeller GmbH
  - Elsterwerda, Germany, 04910
    - ZKS Südbrandenburg GMBH
  - Essen, Germany, 45355
    - Medizentrum Essen Borbeck
  - Essen, Germany, 45355
    - Studienzentrum
  - Essen, Germany, 45355
    - Gemeinschaftspraxis Dres. Hagemann und Breiderhoff
  - Frankfurt, Germany, 60596
    - ClinPhenomics GmbH Co KG Studienzentrum Frankfurt
  - Freiburg im Breisgau, Germany, 79106
    - Universitaetsklinikum Freiburg
  - Hamburg, Germany, 22763
    - Asklepios Klinik Altona
  - Hamburg, Germany, 22415
    - Praxis Dr. Cornelia Schiewe
  - Hamburg, Germany, 20099
    - ClinPhenomics GmbH Co KG Studienzentrum Hamburg
  - Hamburg, Germany, 20099
    - Medizinisches Versorgungszentrum Prof. Mathey, Prof. Schofer GmbH
  - Haßloch, Germany, 67454
    - Killat Dr. Holger Kardiologische Praxis
  - Kassel, Germany, 34121
    - Ambulantes Herzzentrum Kassel
  - Kiel, Germany, 24105
    - Universitaetsklinikum Schleswig Holstein Campus Kiel
  - Ludwigshafen, Germany, 67063
    - Klinikum Ludwigshafen
  - Mainz, Germany, 55131
    - Katholisches Klinikum Mainz; Innere Medizin I- Kardiologie
  - Mannheim, Germany, 68165
    - Praxis Für Pneumologie Und Allergologie
  - Neuwied, Germany, 56564
    - Marienhaus Klinikum
  - Nuremberg, Germany, 90402
    - GP Dr. Haggenmiller PD Dr. Michael Jeserich
  - Papenburg, Germany, 26871
    - Kardiologische Praxis Papenburg
  - Stuhr, Germany, 28816
    - Praxisgemeinschaft Stuhr-Brinkum
  - Tübingen, Germany, 72076
    - Universitaetsklinikum Tuebingen
  - Wermsdorf, Germany, 04779
    - Kardiologische Praxis
  - Witten, Germany, 58455
    - Forschungszentrum Ruhr
  - Worms, Germany, 67550
    - Stadtkrankenhaus Worms
  - Wuppertal, Germany, 42283
    - HELIOS Klinikum Wuppertal GmbH
Greece
- - Alexandroupoli, Greece, 68100
    - Uni General Hospital of Alexandroupolis
  - Athens, Greece, 11527
    - Hippokration Hospital
  - Athens, Greece, 14233
    - General Hospital of Nea Ionia 'Konstantopoulio'
  - Athens, Greece, 115 27
    - General Hospital of Athens G Gennimatas
  - Kallithea, Greece, 17674
    - Onasseio Cardiosurgery Hospital
  - Pátrai, Greece, 26500
    - Patras University Hospital
  - Thessaloniki, Greece, 56429
    - Papageorgiou General Hospital
  - Thessaloniki, Greece, 57010
    - Papanikolaou General Hospital of Thessaloniki
  - Thessaloniki, Greece, 56429
    - Papageorgiou General Hospital 1
Hungary
- - Baja, Hungary, 6500
    - Lausmed Egeszsegugyi es Szolg. Kft.
  - Balatonfüred, Hungary, 8230
    - DRC Gyogyszervizsgalo Kozpont Kft
  - Budapest, Hungary, 1036
    - Obudai Egeszsegugyi Centrum Kft
  - Budapest, Hungary, 1088
    - Semmelweis Egyetem
  - Budapest, Hungary, 1096
    - Gottsegen György Országos Kardiológiai Intézet
  - Budapest, Hungary, 1023
    - Budai Irgalmasrendi Korhaz
  - Budapest, Hungary, 1122
    - Semmelweis Egyetem Varosmajori Sziv- es Ergyogyaszati Klinika
  - Budapest, Hungary, 1106
    - Bajcsy-Zsilinszky Korhaz es Rendelointezet
  - Budapest, Hungary, 1051
    - Belvaros-Lipotvaros Egeszsegugyi Szolgalat
  - Budapest, Hungary, 1085
    - Szt. Rokus Hosp
  - Budapest, Hungary, 1132
    - Med-Tima Kft
  - Budapest, Hungary, 1152
    - Uno Medical Trials Ltd.
  - Budapest, Hungary, 1097
    - Del Pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet Szent Laszlo Telephely
  - Békéscsaba, Hungary, 5600
    - Belgyogyaszati es Kardiologiai Maganrendelo
  - Debrecen, Hungary, 4032
    - Debreceni Egyetem
  - Debrecen, Hungary, 4025
    - Belinus Orvosi es Szamtech. Bt.
  - Debrecen, Hungary, 4032
    - Debreceni Egyetem 1
  - Gyula, Hungary, 5700
    - Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz
  - Gyöngyös, Hungary, 3200
    - Bugat Pal Korhaz
  - Hatvan, Hungary, 3000
    - BKS Research Kft
  - Hódmezővásárhely, Hungary, 6800
    - Csongrád Megyei Egészségügyi Ellátó Központ Hódmezővásárhely
  - Kaposvár, Hungary, 7400
    - Somogy Megyei Kaposi Mor Oktato Korhaz
  - Kecskemét, Hungary, 6000
    - Bacs-kiskun Megyei Korhaz
  - Komárom, Hungary, 2900
    - Selye Janos Korhaz es Rendelointezet
  - Miskolc, Hungary, 3530
    - IPR Hungary Kft
  - Mosonmagyaróvár, Hungary, 9200
    - Karolina Korhaz-Rendelointezet
  - Mosonmagyaróvár, Hungary, 9200
    - TaNaMed Kft.
  - Nyíregyháza, Hungary, H-4405
    - Borbanya Praxis Eu. Kft.
  - Orosháza, Hungary, 5900
    - Dr. Nagy Laszlo Kardiologiai Maganrendeles
  - Pécs, Hungary, 7623
    - COROMED-SMO Kft
  - Szeged, Hungary, 6725
    - Szegedi Tudomanyegyetem
  - Szolnok, Hungary, 5000
    - Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointez
  - Szombathely, Hungary, 9700
    - Markusovszky Egyetemi Oktatokorhaz
  - Székesfehérvár, Hungary, 8000
    - Vita Verum Medical Egeszsegugyi Szolgaltato Bt
  - Zalaegerszeg, Hungary, 8900
    - Belvarosi Egeszseghaz Kft
  - Zalaegerszeg, Hungary, 8900
    - Obudai Egeszsegugyi Centrum Kft 1
India
- - Aligarh, India, 202001
    - Jawaharlal Nehru Medical College and Hospital
  - Amritsar, India, 143004
    - Fortis Escorts Heart Institute and Research Centre
  - Aurangabad, India, 431005
    - Kamal Nayan Bajaj Hospital
  - Bangalore, India, 560034
    - St. John's National Academy of Health Sciences - St. John's Medical College Hospital
  - Bangalore, India, 560069
    - Sri Jayadeva Institute
  - Belagavi, India, 590010
    - KLE's Dr. Prabhakar Kore Hospital & Medical Research Centre (MRC)
  - Bengaluru, India, 560002
    - Bangalore Medical College and Research Institute
  - Bikaner, India, 334003
    - S.P.Medical College & AG of Hospitals
  - Chennai, India, 600002
    - Tamil Nadu Government Multi Super Speciality Hospital
  - Jaipur, India, 302020
    - Eternal Heart Care Centre
  - Jaipur, India, 302006
    - S. R. Kalla Memorial General Hospital
  - Karamsad, India, 388325
    - B M Patel Cardiac Centre
  - Kochi, India, 682018
    - Lisie Hospital
  - Kolkata, India, 700020
    - IPGMER and SSKM Hospital
  - Kolkata, India, 700014
    - NRS Medical college
  - Lucknow, India, 226014
    - Sanjay Gandhi Postgraduate Institute of Medical Sciences
  - Nagar, India, 440015
    - Swasthyam Superspeciality Hospital
  - Nagpur, India, 440010
    - Arneja Heart Institute
  - Nagpur, India, 440015
    - Central India Cardiology Hospital and Research Institute
  - Nashik, India, 422005
    - Chopda Medicare And Research Centre Pvt Ltd Magnum Heart Institute
  - New Delhi, India, 110029
    - All India Institute of Medical Sciences
  - New Delhi, India, 110060
    - Clinical Research Room
  - Patna, India, 800014
    - Indira Gandhi Institute of Medical Sciences
  - Pune, India, 411011
    - KEM Hospital & Research Centre
  - Secunderabad, India, 500003
    - Yashoda Super Speciality Hospitals
  - Shivamogga, India, 577201
    - Nanjappa Hospital
  - Vijayawada, India, 520008
    - Government Siddhartha Medical College
  - Visakhapatnam, India, 530002
    - King George Hospital
Israel
- - Afula, Israel, 18101
    - HaEmek Medical Center
  - Hadera, Israel, 3810101
    - Hillel Yaffe Medical Center
  - Haifa, Israel, 31048
    - Bnai Zion Medical Center
  - Haifa, Israel, 3436212
    - Carmel Medical Center
  - Holon, Israel, 58100
    - Wolfson Medical Center
  - Jerusalem, Israel, 9124001
    - Hadassah Medical Center
  - Jerusalem, Israel, 22100
    - Hadassah University Hospita Ein Kerem
  - Kfar Saba, Israel, 4428164
    - Meir Medical Center
  - Nazareth, Israel, 16100
    - Holy Family Hospital
  - Petah Tikva, Israel, 49100
    - Rabin Medical Center
  - Ramat Gan, Israel, 5262001
    - Chaim Sheba Medical Center
  - Rehovot, Israel, 7610001
    - Kaplan Medical Center
  - Rishon LeZiyyon, Israel, 70300
    - Assaf Harofeh Medical Center
  - Safed, Israel, 13100
    - Ziv Medical Center
Italy
- - Arezzo, Italy, 52100
    - Ospedale San Donato - ASL 8 Arezzo
  - Aversa, Italy, 81031
    - ASL Caserta_Presidio Ospedaliero San Giuseppe e Melorio_U.O.C. di Cardiologia
  - Bergamo, Italy, 24127
    - Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII)
  - Bergamo, Italy, 24125
    - Cliniche Humanitas Gavazzeni
  - Bologna, Italy, 40138
    - Azienda Opedaliero-Universitaria Policlinico Sant'orsola Malpighi di Bologna
  - Caserta, Italy, 81100
    - AORN Sant'Anna e San Sebastiano
  - Catania, Italy, 95124
    - P.O. Vittorio Emanuele Azienda Ospedaliero Universitaria 'Policlinico Vittorio Emanuele'
  - Catanzaro, Italy, 88100
    - AO di Catanzaro Pugliese Ciaccio
  - Ferrara, Italy, 44124
    - Arcispedale S. Anna Ferrara
  - Lecco, Italy, 23900
    - Ospedale Manzoni
  - Massa, Italy, 54100
    - Fondazione Toscana Gabriele Monasterio CNR
  - Milan, Italy, 20122
    - Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
  - Milan, Italy, 20162
    - A O Ospedale Niguarda Ca Granda
  - Modena, Italy, 41124
    - AOU Policlinico di Modena
  - Monza, Italy, 20052
    - Azienda Socio Sanitaria Territoriale di Monza Presidio San Gerardo
  - Pavia, Italy, 27100
    - Fondazione IRCCS Policlinico San Matteo
  - Perugia, Italy, 06156
    - Aou Santa Maria Della Misericordia Di Udine
  - Pisa, Italy, 56126
    - A. O.U. Pisana Ospedale di Cisanello
  - Roma, Italy, 00152
    - A.O. San Camillo Forlanini
  - Roma, Italy, 00161
    - AOU Policlinico Umberto I
  - Roma, Italy, 00157
    - Ospedale Sandro Pertini di Roma Reparto Emodinamica
  - Roma, Italy, 00168
    - Fondazione Policlinico Universitario A Gemelli IRCCS
  - Rozzano, Italy, 20089
    - Istituto Clinico Humanitas
  - Sassari, Italy, 07100
    - P.O. Ss. Annunziata
  - Torino, Italy, 10126
    - Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino
  - Torrette Di Ancona, Italy, 60126
    - Azienda Ospedaliero Universitaria Ospedali Riuniti
Japan
- - Aichi, Japan, 486-8510
    - Kasugai Municipal Hospital
  - Bunkyō City, Japan, 113 8519
    - Tokyo Medical and Dental University Hospital
  - Chiba, Japan, 260 8677
    - Chiba University Hospital
  - Chiba, Japan, 273 8588
    - Funabashi Municipal Medical Center
  - Chikushino-shi, Japan, 818-8516
    - Saiseikai Futsukaichi Hospital
  - Fukuoka, Japan, 810 8563
    - National Hospital Organization Kyushu Medical Center
  - Fukuoka, Japan, 805-0050
    - Steel Memorial Yawata Hospital
  - Fukuoka, Japan, 812 8582
    - Kyushu University Hospital
  - Fukuoka, Japan, 819-1104
    - Junshinkai Nakamura Cardiovascular Clinic
  - Funabashi-shi, Japan, 274-8503
    - Chiba Tokushukai Hospital
  - Gifu, Japan, 500-8717
    - Gifu Prefectural General Medical Center
  - Higashiibaraki-gun, Japan, 311-3193
    - National Hospital Organization Mito Medical Center
  - Hirosaki-shi, Japan, 036-8562
    - Hirosaki University Hospital
  - Hiroshima, Japan, 734-8530
    - Hiroshima Prefectural Hospital
  - Hiroshima, Japan, 734 8551
    - Hiroshima University Hospital
  - Hokkaido, Japan, 053-8567
    - Tomakomai City Hospital
  - Hyōgo, Japan, 660-8550
    - Hyogo Prefectural Amagasaki General Medical Center
  - Isehara, Japan, 259-1193
    - Tokai University Hospital
  - Ishikawa, Japan, 924-0865
    - Public Central Hospital of Matto Ishikawa
  - Ishikawa, Japan, 920 8650
    - National Hospital Organization Kanazawa Medical Center
  - Itabashi Ku, Japan, 173 8606
    - Teikyo University Hospital
  - Kagoshima, Japan, 892-0822
    - Central Clinic
  - Kasuga-shi, Japan, 816-0864
    - Fukuoka Tokushukai Hospital
  - Kawasaki-shi, Japan, 212-0021
    - Sekishinkai Second Kawasaki Saiwai Clinic
  - Kitakyushu-shi, Japan, 802-8555
    - Kokura Memorial Hospital
  - Kumamoto, Japan, 861-4193
    - Saiseikai Kumamoto Hospital
  - Kumamoto, Japan, 860-8556
    - Kumamoto University Hospital
  - Kusatsu-shi, Japan, 525-8585
    - Seikokai Omi Medical Center
  - Kyoto, Japan, 606-8507
    - Kyoto University Hospital
  - Matsuyama, Japan, 790-0024
    - Ehime Prefectural Central Hospital
  - Mito, Japan, 310-0055
    - Seijunkai Mito Hospital
  - Miyazaki, Japan, 880-2102
    - Miyazaki Medical Association Hospital
  - Miyazaki, Japan, 885-0002
    - Miyakonojo Medical Association Hospital
  - Nagoya, Japan, 466-8650
    - Japanese Red Cross Nagoya Daini Hospital
  - Narashino-shi, Japan, 275-8580
    - Saiseikai Narashino Hospital
  - Nishi-Tokyo-shi, Japan, 202-0012
    - Miwa Heart Clinic
  - Nishinomiya Shi, Japan, 663 8501
    - Hyogo Medical University Hospital
  - Okayama, Japan, 700-8558
    - Okayama University Hospital
  - Okinawa, Japan, 902-8511
    - Naha City Hospital
  - Osaka, Japan, 540-0006
    - National Hospital Organization Osaka National Hospital
  - Osaka, Japan, 565-0871
    - Osaka University Hospital
  - Osaka, Japan, 543-0035
    - Osaka Police Hospital
  - Osaka, Japan, 530-0001
    - Watanabeigakukai Sakurabashi Watanabe Hospital
  - Osaka Sayama Shi, Japan, 589 8511
    - Kindai University Hospital
  - Sagamihara, Japan, 252-0375
    - Kitasato University Hospital
  - Saitama-shi, Japan, 339-0033
    - Iwatsuki Minami Hospital
  - Sapporo, Japan, 003-0026
    - Matsuda Hospital
  - Sapporo, Japan, 064-8570
    - Sanseikai Miyanomori Memorial Hospital
  - Sendai, Japan, 980 8574
    - Tohoku University Hospital
  - Shinagawa City, Japan, 142 8666
    - Showa University Hospital
  - Shinjuku-ku, Japan, 162-8666
    - Tokyo Women's Medical University Hospital
  - Suita-Shi, Japan, 564-8565
    - National Cerebral and Cardiovascular Center
  - Takatsuki-shi, Japan, 569-1096
    - Japanese Red Cross Takatsuki Hospital
  - Tokyo, Japan, 160-0023
    - Tokyo Medical University Hospital
  - Tokyo, Japan, 192-0038
    - Kenshinkai Minamino Cardiovascular Hospital
  - Tokyo, Japan, 181 8611
    - Kyorin University Hospital
  - Tokyo, Japan, 113 8603
    - Nippon Medical School Hospital
  - Tokyo, Japan, 173 8610
    - Nihon University Itabashi Hospital
  - Tokyo, Japan, 106-0031
    - The Cardiovascular Institute Hospital
  - Tokyo, Japan, 198-0042
    - Ome Medical Center
  - Tomakomai, Japan, 053-8506
    - Oji General Hospital
  - Toyoake, Japan, 470-1192
    - Fujita Health University Hospital
  - Toyota-shi, Japan, 471-8513
    - Toyota Memorial Hospital
  - Uwajima-shi, Japan, 798-8510
    - Uwajima City Hospital
  - Yokohama, Japan, 222-0036
    - Yokohama Rosai Hospital
  - Yokohama, Japan, 232 0024
    - Yokohama City University Medical Center
  - Yufu, Japan, 879-5593
    - Oita University Hospital
Latvia
- - Daugavpils, Latvia, LV5417
    - Daugavpils Regional Hospital
  - Riga, Latvia, LV-1002
    - Pauls Stradins Clinical University Hospital
  - Riga, Latvia, LV-1038
    - Riga East Clinical University Hospital
Lithuania
- - Kaunas, Lithuania, 49449
    - Saules Seimos Medicinos Centras, JSC
  - Kaunas, Lithuania, 49387
    - Klinikiniai sprendimai JSC
  - Kaunas, Lithuania, LT-47144
    - Kaunas Clinical Hospital, Public Institution
  - Klaipėda, Lithuania, LT-92288
    - Klaipeda Seamen's Hospital, Public Institution
  - Vilnius, Lithuania, LT-08661
    - Vilnius University Hospital Santariskiu Clinic, Public Institution
  - Vilnius, Lithuania, LT-08406
    - Inlita, JSC
  - Vilnius, Lithuania, LT-08406
    - Inmedica, JSC
  - Vilnius, Lithuania, 08661
    - Vilnius University Hospital Santariskiu Clinic, Public Institution 1
Malaysia
- - Alor Star, Malaysia, 05460
    - Hospital Sultanah Bahiyah
  - Kota Bharu, Malaysia, 15200
    - Hospital University Sains Malaysia
  - Kota Kinabalu, Malaysia, 88300
    - Queen Elizabeth II Hospital
  - Kuala Lumpur, Malaysia, 50400
    - Institut Jantung Negara
  - Kuantan, Malaysia, 25100
    - Hospital Tengku Ampuan Afzan
  - Selayang Baru Utara, Malaysia, 68000
    - Universiti Teknologi Mara
  - Seri Manjung, Malaysia, 32040
    - Hospital Seri Manjung
  - Taiping, Malaysia, 34000
    - Hospital Taiping
Netherlands
- - 's-Hertogenbosch, Netherlands, 5223 GZ
    - Jeroen Bosch ziekenhuis
  - Alkmaar, Netherlands, 1815 JD
    - Noordwest Ziekenhuisgroep
  - Almelo, Netherlands, 7609
    - ZGT Cardioresearch
  - Amersfoort, Netherlands, 3813 TZ
    - Meander Medisch Centrum
  - Amsterdam, Netherlands, 1081 HV
    - VUMC Amsterdam
  - Amsterdam, Netherlands, 1091 AC
    - Onze Lieve Vrouwe Gasthuis
  - Delft, Netherlands, 2625 AD
    - Reinier de Graaf Gasthuis
  - Deventer, Netherlands, 7416 SE
    - Deventer Ziekenhuis
  - Doetinchem, Netherlands
    - Slingeland Ziekenhuis
  - Ede, Netherlands, 6716 RP
    - Ziekenhuis Gelderse Vallei
  - Eindhoven, Netherlands, 5623 EJ
    - Catharina Ziekenhuis
  - Gouda, Netherlands, 2800 BB
    - Groene Hart Ziekenhuis
  - Heerlen, Netherlands, 6419 PC
    - Atrium Med.Centrum Heerlen - Afd.Interne - INT
  - Helmond, Netherlands, 5707 HA
    - Elkerliek Ziekenhuis
  - Leiderdorp, Netherlands, 2353 GA
    - Alrijne Ziekenhuis Leiden ; Cardiology
  - Nieuwegein, Netherlands, 3435 CM
    - St. Antonius Ziekenhuis Nieuwegein
  - Nijmegen, Netherlands, 6525GA
    - Radboudumc
  - Rotterdam, Netherlands, 3083 AN
    - Ikazia Ziekenhuis
  - Rotterdam, Netherlands, 3045 PM
    - Sint Franciscus Gasthuis
  - Sneek, Netherlands, 8601 ZR
    - D & A Research
  - Tilburg, Netherlands, 5022 GC
    - ETZ Elisabeth
  - Veldhoven, Netherlands, 5504 DB
    - Maxima Medisch Centrum
  - Zutphen, Netherlands, 7207 AE
    - Gelre Ziekenhuizen Zutphen
New Zealand
- - Auckland, New Zealand, 1030
    - Auckland City Hospital
  - Auckland, New Zealand, 0740
    - North Shore Hospital
  - Christchurch, New Zealand, 8140
    - University of Otago
  - Dunedin, New Zealand, 9016
    - Dunedin Public Hospital
  - Hamilton, New Zealand, 3200
    - Waikato Hospital
  - Hastings, New Zealand
    - Hawkes Bay Hospital
  - New Plymouth, New Zealand, 4342
    - Taranaki Base Hospital
  - Otahuhu, New Zealand, 2025
    - Middlemore Hospital
  - Rotorua, New Zealand, 3010
    - Rotorua Hospital
  - Tauranga, New Zealand, 3143
    - Tauranga Hospital
Philippines
- - Cavite, Philippines, 4118
    - Silang Specialists Medical Center
  - Cebu City, Philippines, 6000
    - Perpetual Succour Hospital
  - Davao City, Philippines, 8000
    - Davao Doctors Hospital
  - Davao City, Philippines, 8000
    - Central Lab Diabetes Wellness, Heart and Kidneys, Inc
  - Iloilo City, Philippines, 5000
    - St.Paul's Hospital-Iloilo
  - Lipa City, Philippines, 4217
    - Mary Mediatrix Medical Center
  - Manila, Philippines, 1634
    - St. Luke's Medical Center
  - San Fernando City, Philippines, 2000
    - GreenCity Medical Center
  - San Juan City, Philippines, 1502
    - Cardinal Santos Medical Center
Poland
- - Biała Podlaska, Poland, 21 500
    - Wojewódzki Szpital Specjalistyczny
  - Bydgoszcz, Poland, 85-796
    - Centrum medyczne Pratia Bydgoszcz
  - Bydgoszcz, Poland, 85 231
    - NZOZ Centrum Medyczne KERmed
  - Bydgoszcz, Poland, 85 048
    - IN VIVO Sp. z o.o
  - Bydgoszcz, Poland, 85 605
    - Centrum Medyczne Intercor Sp z o o
  - Chojnice, Poland, 89 600
    - Centrum Medyczne Pratia Chojnice
  - Chorzów, Poland, 41-500
    - DIAB SERWIS Popenda Sp. Jawna Specjalistyczna Przychodnia Lekarska
  - Chorzów, Poland, 41-500
    - M2M MED Badania Spolka z o. o
  - Chrzanów, Poland, 32-500
    - Centrum Medyczne MBB-MED
  - Elblag, Poland, 82-300
    - NZOZ Twoje Zdrowie El
  - Gdansk, Poland, 80-286
    - Poradnia Kardiologiczna Jaroslaw Jurowiecki
  - Gdynia, Poland, 81-157
    - Private Practice - Dr. Krzysztof Cymerman
  - Gdynia, Poland, 81-423
    - NZOZ Procordis Pawel Miekus
  - Grodzisk Mazowiecki, Poland, 05 825
    - MCBK Iwona Czajkowska Anna Podrazka Szczepaniak S C
  - Jelenia Góra, Poland, 58 506
    - Centrum Medyczne Pratia Jelenia Gora
  - Katowice, Poland, 40-555
    - Kardio Klinika Brynow
  - Katowice, Poland, 40-282
    - Silmedic sp. z o.o
  - Katowice, Poland, 40-156
    - Clinical Medical Research Sp. z o.o.
  - Katowice, Poland, 40 081
    - Centrum Medyczne Pratia Katowice
  - Katowice, Poland, 40-752
    - Niepubliczny Zaklad Opieki Zdrowotnej
  - Kielce, Poland, 25-525
    - Specjalistyczna Poradnia Kardiologiczna i Nadcisnienia Tetniczego
  - Krakow, Poland, 30-082
    - Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska
  - Krakow, Poland, 30-721
    - Centrum Medyczne Linden
  - Krakow, Poland, 31 216
    - Centrum Medyczne Zdrowa J Trebacz W Zajdel s j
  - Krakow, Poland, 31-501
    - Krakowskie Centrum Medyczne Sp z o o NZOZ
  - Krakow, Poland, 31-826
    - Odzial Kardiologii i Chorob Wewnetrznych Szpital Specjalistyczny im. Ludwika Rydygiera
  - Legnica, Poland, 59-220
    - B.Miklaszewicz&D.Dabrowski CARDIMED Spolka Jawna
  - Lodz, Poland, 94-255
    - Indywidualna Specjalistyczna Praktyka Lekarska
  - Lodz, Poland, 94-048
    - NZOZ ALL-MED Centrum Medyczne Specjalistyczne Gabinety Lekarskie
  - Lodz, Poland, 91 363
    - Centrum Medyczne AMED oddzial w Lodzi
  - Lodz, Poland, 93 338
    - Instytut Centrum Zdrowia Matki Polki
  - Lodz, Poland, 91 034
    - Centrum Medyczne Med Gastr
  - Lodz, Poland, 90 302
    - SANTA FAMILIA Centrum Badan Profilaktyki i Leczenia
  - Lowicz, Poland, 99 400
    - Lowickie Centrum Kardiologii
  - Lublin, Poland, 20 049
    - 1 Wojskowy Szpital Kliniczny Z Poliklinika SPZOZ W Lublinie
  - Lublin, Poland, 20 362
    - KO MED Centra Kliniczne LUBLIN
  - Lublin, Poland, 20 412
    - ETG Lublin
  - Olsztyn, Poland, 10-010
    - FutureMeds Olsztyn
  - Ostrowiec Świętokrzyski, Poland, 27-400
    - Ostrowieckie Centrum Medyczne Spólka Cywilna Anna Olech-Cudzik, Krzysztof Cudzik
  - Oświęcim, Poland, 32-600
    - Medicome Sp. z o.o.
  - Piaseczno, Poland, 05-500
    - Nzoz Heureka
  - Poznan, Poland, 60-693
    - Med-Polonia Sp. z o.o.
  - Poznan, Poland, 61 853
    - NZOZ NEURO KARD Ilkowski i Partnerzy Sp Partnerska Lekarzy
  - Przemyśl, Poland, 37-700
    - Wojewodzki Szpital im Sw Ojca Pio w Przemyslu
  - Ruda Śląska, Poland, 41-709
    - Janusz Spyra Specjalistyczna Praktyka Lekarska
  - Rzeszów, Poland, 35-055
    - Centrum Medyczne Medyk
  - Siedlce, Poland, 08-110
    - ETG Siedlce
  - Siedlce, Poland, 08-110
    - Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Siedlcach
  - Skierniewice, Poland, 96-100
    - Velocity Nova spolka z ograniczona odpowiedzialnoscia
  - Warsaw, Poland, 02-793
    - ETG Warszawa
  - Warsaw, Poland, 02 637
    - Narodowy Instytut Geriatrii Reumatologii i Rehabilitacji im prof dr hab med Eleonory Reicher
  - Warsaw, Poland, 00 2015
    - FutureMeds Warszawa Centrum
  - Warsaw, Poland, 03 291
    - FutureMeds Targówek
  - Wroclaw, Poland, 53-030
    - CM Sedimed Wroclaw
  - Wroclaw, Poland, 50 368
    - Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu
  - Wroclaw, Poland, 50 981
    - 4 Wojskowy Szpital Kliniczny z Poliklinika SP ZOZ
  - Wroclaw, Poland, 51 314
    - NZOZ Zdrowie s c Agnieszka i Donald Drozdz
  - Zamość, Poland, 22-400
    - Velocity Zamosc
  - Zamość, Poland, 22 400
    - ETG Zamosc
  - Żarów, Poland, 58-130
    - Centrum Medyczne Serafin med
Portugal
- - Coimbra, Portugal, 3000-075
    - Uls Coimbra - Hosp. Univ. Coimbra
  - Covilha, Portugal, 6200-074
    - Centro Hospitalar Cova da Beira, EPE - Hospital Pêro da Covilhã
  - Figueira da Foz Municipality, Portugal, 3094-001
    - Hospital Distrital Fig Da Foz Gala
  - Lisbon, Portugal, 1649-035
    - Centro Hospitalar de Lisboa Norte Hospital Santa Maria
  - Lisbon, Portugal, 2790-134
    - Centro Hospitalar Lisboa Ocidental - Hospital São Fracisco Xavier
  - Santa Maria da Feira, Portugal, 4520-211
    - Centro Hospitalar de Entre o Douro e Vouga, E.P.E
  - Torres Novas, Portugal, 2350-325
    - Largo da Igreja Velha Edifício CCA
  - Vila Nova de Gaia, Portugal, 4434-502
    - Centro Hospitalar de Vila Nova de Gaia Espinho E P E
  - Vila Real, Portugal, 5000-508
    - Centro Hospitalar de Trás os Montes e Alto Douro- Vila Real
Romania
- - Baia Mare, Romania, 430222
    - CMI Cardiologie Dr. Calin Pop
  - Brasov, Romania, 500283
    - Centrul Medical de Diagnostic si Tratament Ambulator Neomed
  - Brasov, Romania, 500091
    - Centrul Medical Unirea SRL
  - Brăila, Romania, 810119
    - Spitalul Judetean de Urgenta Braila
  - Bucharest, Romania, 050659
    - Spitalul Clinic de Urologie Prof. Dr. Theodor Burghele
  - Bucharest, Romania, 022322
    - Institutul de urgenta pentru Boli Cardiovasculare Prof. Dr. C.C. Iliescu
  - Bucharest, Romania, 010192
    - Clinica Medicala Data Plus SRL
  - Bucharest, Romania, 011794
    - Centrul Medical de Diagnostic si Tratament Ambulatoriu si Medicina Preventiva
  - Bucharest, Romania, 014142
    - S C Delta Health Care S R L
  - Cluj-Napoca, Romania, 400000
    - Spitalul Angiocare SRL
  - Iași, Romania, 700503
    - Institutul de Boli Cardiovasculare Iasi
  - Iași, Romania, 700786
    - Cardiomed SRL
  - Oradea, Romania, 410169
    - Spitalul Clinic Judetean de Urgenta Oradea
  - Piteşti, Romania, 110424
    - SAL MED Pitesti
  - Sibiu, Romania, 550245
    - Spitalul Clinic Judetean Sibiu
  - Suceava, Romania, 720049
    - Cabinet Medical Cardiologie Cojocariu Titel Razvan
  - Tg. Mures, Romania, 540136
    - Spitalul Clinic Judetean de Urgenta Targu Mures
  - Timișoara, Romania, 300043
    - Clinica Medicaliss
  - Târgu Mureş, Romania, 540143
    - Cmi Dr Podoleanu Cristian
Serbia
- - Belgrade, Serbia, 11080
    - Clinical Center Bezanijska kosa
  - Belgrade, Serbia, 11000
    - University Clinical Center of Serbia
  - Belgrade, Serbia, 11080
    - University Clinical Hospital Center Dr Dragisa Misovic- Dedi
  - Belgrade, Serbia, 11000
    - Institute for Cardiovascular diseases Dedinje
  - Belgrade, Serbia, 11000
    - University Clinical Center of Serbia 1
  - Belgrade, Serbia, 11000
    - University Clinical Center of Serbia 2
  - Belgrade, Serbia, 11040
    - Institute for Cardiovascular diseases Dedinje 1
  - Belgrade, Serbia, 11040
    - Institute for Cardiovascular diseases Dedinje 2
  - Belgrade, Serbia, 11080
    - University Clinical Hospital Center Dr Dragisa Misovic- Dedi 1
  - Kamenitz, Serbia, 21204
    - Institute of Cardiovascular Diseases of Vojvodina
  - Kragujevac, Serbia, 34000
    - Clinical Center of Kragujevac
  - Niš, Serbia, 18000
    - Clinical Center Nis
  - Niška Banja, Serbia, 18205
    - Institute for Treatment and Rehabilitation Niska Banja
  - Pančevo, Serbia, 26000
    - General Hospital Pancevo
  - Smederevo, Serbia, 11300
    - General Hospital Smederevo
  - Sremska Mitrovica, Serbia, 22000
    - General Hospital Sremska Mitrovica
  - Užice, Serbia, 31000
    - General Hospital Uzice
  - Zaječar, Serbia, 19000
    - Health Center Zajecar
Singapore
- - Singapore, Singapore, 169856
    - Singapore General Hospital
  - Singapore, Singapore, 169609
    - National Heart Centre (NHC) Singapore
Slovakia
- - Bardejov, Slovakia, 08501
    - Alian s.r.o.
  - Bardejov, Slovakia, 08501
    - Thyreomedical s r o
  - Bratislava, Slovakia, 83348
    - Narodny ustav srdcovych a cievnych chorob
  - Bratislava, Slovakia, 83101
    - Kardiovaskularne centrum, s.r.o.
  - Bratislava, Slovakia, 81104
    - Cardioconsult s.r.o.
  - Bratislava, Slovakia, 82101
    - Univerzitna nemocnica Bratislava
  - Bratislava, Slovakia, 85101
    - Veria, s.r.o Kardiologicka ambulancia
  - Brezno, Slovakia, 977 01
    - Nemocnica s poliklinikou Brezno
  - Dolný Kubín, Slovakia, 02601
    - KARDIO-ONKOLOGIA s.r.o. Kardiologicka ambulancia
  - Košice, Slovakia, 040 11
    - Východoslovenský Ústav Srdcových A Cievnych Chorôb, A.S.
  - Košice, Slovakia, 04022
    - Cardio D&R, s.r.o.
  - Košice, Slovakia, 4001
    - Kardiologicka ambulancia Medicalgroup s.r.o.
  - Lučenec, Slovakia, 98401
    - IN-DIA s.r.o.
  - Lučenec, Slovakia, 98401
    - KARDIO 1 s.r.o.
  - Lučenec, Slovakia, 98401
    - Kardiomed, S.R.O.
  - Moldava nad Bodvou, Slovakia, 4501
    - Kardiologicka ambulancia MEDI M&M s.r.o.
  - Nitra, Slovakia, 95001
    - Fakultna nemocnica Nitra
  - Nové Zámky, Slovakia, 94052
    - Cardioinvest s.r.o.
  - Prešov, Slovakia, 08001
    - Medispol s.r.o Interna a kardiologicka ambulancia
  - Prešov, Slovakia, 08081
    - Fakultna nemocnica s poliklinikou J.A. Reimana Presov
  - Svidník, Slovakia, 08901
    - Interna SK s.r.o.
  - Žilina, Slovakia, 01001
    - MEDIVASA s.r.o.
South Africa
- - Cape Town, South Africa, 7500
    - TREAD Research
  - Centurion, South Africa, 0157
    - Johese Clinical Research
  - Johannesburg, South Africa, 2192
    - Garda, RA
  - Krugersdorp, South Africa, 1739
    - DJW Research
  - Pretoria, South Africa, 0002
    - Clinical Research Unit, University of Pretoria
  - Pretoria, South Africa, 0181
    - Into Research
  - Somerset West, South Africa, 7130
    - Dr J.M. Engelbrecht Trial Site
  - Somerset West, South Africa, 7130
    - Helderberg Research Institute
  - Tongaat, South Africa, 4399
    - Mediclinic Victoria Hospital
  - Worcester, South Africa, 6850
    - Clinical Projects Research SA (PTY) LTD
South Korea
- - Anyang-si, South Korea, 431-796
    - Hallym University Sacred Heart Hospital
  - Busan, South Korea, 49241
    - Pusan National University Hospital
  - Busan, South Korea, 47392
    - Inje University Busan Paik Hospital
  - Busan, South Korea, 602 812
    - Dong-A University Hospital
  - Cheonan-si, South Korea, 31116
    - Dankook University Hospital
  - Cheongju-si, South Korea, 28644
    - Chungbuk National University Hospital
  - Chuncheon, South Korea, 24289
    - Kangwon National University Hospital
  - Daegu, South Korea, 42601
    - Keimyung University Dongsan Hospital
  - Daejeon, South Korea, 35015
    - Chungnam National University Hospital
  - Goyang-si, South Korea, 10380
    - Inje University Ilsan Paik Hospital
  - Guri-si, South Korea, 471-701
    - Hanyang University Guri Hospital
  - Gwangju, South Korea, 61469
    - Chonnam National University Hospital
  - Gyeonggi-do, South Korea, 13496
    - Cha Bundang Medical Center, Cha University
  - Incheon, South Korea, 21565
    - Gachon University Gil Medical Center
  - Incheon, South Korea, 22322
    - Inha University Hospital
  - Jeju Special, South Korea, 63241
    - Jeju National University Hospital
  - Sejong-si, South Korea, 30099
    - Chungnam National University Hospital 1
  - Seongnam, South Korea, 13620
    - Seoul National University Bundang Hospital
  - Seoul, South Korea, 03080
    - Seoul National University Hospital
  - Seoul, South Korea, 05505
    - Asan Medical Center
  - Seoul, South Korea, 06351
    - Samsung Medical Center
  - Seoul, South Korea, 02841
    - Korea University Anam Hospital
  - Seoul, South Korea, 06591
    - The Catholic University of Korea Seoul St Mary s Hospital
  - Seoul, South Korea, 152-703
    - Korea University Guro Hospital
  - Seoul, South Korea, 07985
    - Ewha Womans University Mokdong Hospital
  - Seoul, South Korea, 120-752
    - Severance Hospital Yonsei University Health System
  - Seoul, South Korea, 130 050
    - Kyung Hee University Hospital
  - Seoul, South Korea, 03312
    - The Catholic University of Korea Seoul St Marys Hospital
  - Seoul, South Korea, 04763
    - Hanyang University Hospital
  - Seoul, South Korea, 03080
    - Seoul National University Hospital 1
  - Suwon, South Korea, 16499
    - Ajou University Hospital
  - Wŏnju, South Korea, 220-701
    - Wonju Severance Christian Hospital
  - Yongin-si, South Korea, 16995
    - Yongin Severance Hospital
Spain
- - A Coruña, Spain, 15006
    - Hosp Univ A Coruna
  - Alicante, Spain, 3540
    - Hosp. Gral. Univ. de Alicante
  - Barcelona, Spain, 08041
    - Hosp. de La Santa Creu I Sant Pau
  - Barcelona, Spain, 08003
    - Hosp. Del Mar
  - Barcelona, Spain, 08907
    - Hosp. Univ. de Bellvitge
  - El Palmar, Spain, 30120
    - Hosp. Univ. Virgen de La Arrixaca
  - Lleida, Spain, 25198
    - Hosp. Univ. Arnau de Vilanova de Lleida
  - Madrid, Spain, 28046
    - Hosp. Univ. La Paz
  - Madrid, Spain, 28006
    - Hosp. Univ. de La Princesa
  - Madrid, Spain, 28003
    - Hosp. Virgen de La Luz
  - Manises, Spain, 46940
    - Hosp. de Manises
  - Málaga, Spain, 29010
    - Hosp Virgen de La Victoria
  - Sabadell, Spain, 08208
    - Corporacio Sanitari Parc Tauli
  - Santiago de Compostela, Spain, 15706
    - Hosp. Clinico Univ. de Santiago
  - Valencia, Spain, 46010
    - Hosp. Clinico Univ. de Valencia
  - Valencia, Spain, 46014
    - Hosp. Clinico Univ. de Valencia 1
Taiwan
- - Changhua, Taiwan, 50006
    - Changhua Christian Hospital
  - Kaohsiung City, Taiwan, 82445
    - E-DA Hospital
  - Kaohsiung City, Taiwan, 80756
    - Kaohsiung Medical University Chung Ho Memorial Hospital
  - New Taipei City, Taiwan, 22060
    - Far Eastern Memorial Hospital
  - New Taipei City, Taiwan, 25160
    - Mackay Memorial Hospital
  - Taichung, Taiwan, 40447
    - China Medical University Hospital
  - Taipei, Taiwan, 10002
    - National Taiwan University Hospital
  - Taipei, Taiwan, 11490
    - Tri-Service General Hospital
  - Taipei, Taiwan, 106
    - Cathay General Hospital
  - Taipei, Taiwan, 116
    - Taipei Municipal Wanfang Hospital
  - Taipei, Taiwan, 112201
    - Taipei Veterans General Hospital
  - Taoyuan County, Taiwan, 33305
    - Chang Gung Memorial Hospital- Linkou
Turkey (Türkiye)
- - Afyonkarahisar, Turkey (Türkiye), 03200
    - Afyon Kocatepe University Medical Faculty
  - Ankara, Turkey (Türkiye), 06100
    - Turkiye Yuksek Ihtisas Training and Research Hospital
  - Antalya, Turkey (Türkiye), 07070
    - Akdeniz University Medical Faculty
  - Istanbul, Turkey (Türkiye), 34899
    - Marmara University Pendik Training Hospital
  - Izmir, Turkey (Türkiye), 35340
    - Dokuz Eylul University Medical Faculty
  - Kayseri, Turkey (Türkiye), 38039
    - Erciyes University Medical Faculty
  - Mersin, Turkey (Türkiye), 33020
    - Mersin University Medical Faculty
  - Mersin, Turkey (Türkiye), 33330
    - Mersin University Medical Faculty Hospital
  - Samsun, Turkey (Türkiye), 55139
    - Ondokuz Mayis University
United Kingdom
- - Bristol, United Kingdom, BS1 3NU
    - Bristol Royal Infirmary
  - Clydebank, United Kingdom, G81 4HX
    - Golden Jubilee National Hospital
  - Dorchester, United Kingdom, DT1 2JY
    - Dorset County Hospital
  - Exeter, United Kingdom, EX2 5DW
    - Royal Devon and Exeter Hospital(Wonford)
  - High Wycombe, United Kingdom, HP11 2TT
    - Wycombe Hospital
  - Lincoln, United Kingdom, LN2 5QY
    - Lincoln County Hospital
  - London, United Kingdom, EC1A 7BE
    - Barts Hospital
  - Sheffield, United Kingdom, S5 7AU
    - Northern General Hospital
  - Stevenage, United Kingdom, SG1 4AB
    - Lister Hospital
  - Truro, United Kingdom, TR1 3LJ
    - Royal Cornwall Hospital
  - Wigan, United Kingdom, WN1 2NN
    - Wrightington Hospital,Wrightington, Wigan and Leigh NHS Trus
  - Worcester, United Kingdom, WR5 1DD
    - Worcestershire Royal Hospital
United States
- Alabama
  - Alexander City, Alabama, United States, 35010
    - Advanced Cardiovascular, LLC
  - Birmingham, Alabama, United States, 35205
    - Ascension St. Vincent's Health System
  - Dothan, Alabama, United States, 36303
    - SEC Clinical Research
  - Huntsville, Alabama, United States, 35801
    - HH Heart Center and Heart Center
  - Mobile, Alabama, United States, 36608
    - CB Flock Research Corporation
- Arizona
  - Gilbert, Arizona, United States, 85297
    - Mercy Gilbert Medical Center
  - Phoenix, Arizona, United States, 85016
    - Arizona Heart Hospital
  - Phoenix, Arizona, United States, 85008
    - Valleywise Health Medical Center
  - Phoenix, Arizona, United States, 85016
    - Arizona Arrhythmia Research Center
  - Scottsdale, Arizona, United States, 85251
    - HonorHealth Neurology
  - Scottsdale, Arizona, United States, 85251
    - HonorHealth Neurology 1
- Arkansas
  - Little Rock, Arkansas, United States, 72211
    - Arkansas Heart Hospital
- California
  - Bakersfield, California, United States, 93301
    - Bakersfield Memorial Hospital
  - Beverly Hills, California, United States, 90211
    - Vitality Clinical Research
  - Chula Vista, California, United States, 91911
    - Sharp Chula Vista Medical Center
  - Chula Vista, California, United States, 91910
    - Chula Vista Cardiac Clinic
  - Fremont, California, United States, 94538
    - Mission Cardiovascular Research Institute
  - Glendora, California, United States, 91741
    - Paradise Clinical Research Group LLC
  - Long Beach, California, United States, 90806
    - Miller Children's at Long Beach Medical Center
  - Los Angeles, California, United States, 90033
    - University of Southern California
  - Los Angeles, California, United States, 90017
    - Los Angeles Cardiology Associates
  - Merced, California, United States, 95340
    - Merced Vein and Vascular Center
  - Newport Beach, California, United States, 92663
    - Radin Cardiovascular Medical Group
  - Northridge, California, United States, 91325
    - Valley Clinical Trials, Inc.
  - Northridge, California, United States, 91324
    - California Medical Research Associates, Inc.
  - Palm Springs, California, United States, 92262
    - Desert Oasis Health Care
  - Pasadena, California, United States, 91105
    - Havana Research Institute LLC
  - Rancho Mirage, California, United States, 92270
    - Eisenhower Desert Cardiology Center
  - Redwood City, California, United States, 94063
    - Stanford Health Care
  - San Diego, California, United States, 92123
    - San Diego Cardiac Center
  - Santa Ana, California, United States, 92705
    - Syrentis Clinical Research
  - Stockton, California, United States, 95204
    - Ramin Manshadi, MD
  - Torrance, California, United States, 90502
    - UCLA School of Medicine
  - Ventura, California, United States, 93003
    - Cardiology Associates Medical Group
  - Vista, California, United States, 92083
    - North County Internal Medicine
  - Walnut Creek, California, United States, 94598
    - John Muir Physician Network Clin. Research Center
- Colorado
  - Aurora, Colorado, United States, 80012
    - Aurora Denver Cardiology Associates
  - Denver, Colorado, United States, 80218
    - Aurora Denver Cardiology Associates 1
  - Wheat Ridge, Colorado, United States, 80033
    - Paradigm Clinical Research Centers, Inc.
- Connecticut
  - Bridgeport, Connecticut, United States, 06610
    - Bridgeport Hospital
  - Danbury, Connecticut, United States, 06810
    - Western Connecticut Health Network/Danbury Hospital
  - Stamford, Connecticut, United States, 06905
    - Cardiology Associates of Fairfield County
  - Trumbull, Connecticut, United States, 06611
    - PriMed Physicians, A Member of NE Medical Group
- Delaware
  - Newark, Delaware, United States, 19713
    - Cardiology Physicians
- District of Columbia
  - Washington D.C., District of Columbia, United States, 20037
    - George Washington University School of Medicine
- Florida
  - Altamonte Springs, Florida, United States, 32714
    - Orlando Heart Specialists
  - Brandon, Florida, United States, 33511
    - Bay Area Cardiology Associates, P.A. - Brandon Office
  - Clearwater, Florida, United States, 33756
    - Clearwater Cardiovascular Consultants
  - Daytona Beach, Florida, United States, 32117
    - Cardiology Associates Research Company
  - Daytona Beach, Florida, United States, 32114
    - Cardiology Consultants
  - DeLand, Florida, United States, 32720
    - Accel Research Sites
  - Gainesville, Florida, United States, 32605
    - The Cardiac & Vascular Institute Research Foundation
  - Gainesville, Florida, United States, 32610-0226
    - University of Florida College of Medicine
  - Jacksonville, Florida, United States, 32216
    - East Coast Institute for Research
  - Lakeland, Florida, United States, 33805
    - Watson Clinic
  - Largo, Florida, United States, 33777
    - Clearwater Cardiovascular Consultants 1
  - Miami, Florida, United States, 33155
    - Miami Clinical Research
  - Miami, Florida, United States, 33173
    - Suncoast Research Associates, LLC
  - Miami, Florida, United States, 33165
    - Reliant Medical Research
  - Miramar Beach, Florida, United States, 32550
    - Ascension Sacred Heart Hospital
  - New Port Richey, Florida, United States, 34652
    - Suncoast Clinical Research
  - Orange City, Florida, United States, 32763-9116
    - Central Florida Medical Associates
  - Palm Beach Gardens, Florida, United States, 33410
    - Cardiology Partners Clinical Research Institute
  - Pensacola, Florida, United States, 32501
    - Cardiology Consultants 1
  - Pompano Beach, Florida, United States, 33064
    - North Broward Hospital District
  - Port Charlotte, Florida, United States, 33952
    - Charlotte Heart Group Research Center
  - Safety Harbor, Florida, United States, 34695
    - Coastal Cardiology Consultants
  - Sarasota, Florida, United States, 34239-3513
    - Cardiovascular Center of Sarasota
  - St. Petersburg, Florida, United States, 33705
    - Heart and Vascular Institute of Florida
  - Tampa, Florida, United States, 33606
    - University Of South Florida
  - Tampa, Florida, United States, 33613
    - Florida Hospital Tampa
  - Tampa, Florida, United States, 33607
    - Adtremed Inc
  - Tampa, Florida, United States, 33634
    - Helping Hands Health Center dba Helping Hands Evolution Research
  - Wellington, Florida, United States, 33449
    - Cardiology Partners Clinical Research Institute 1
- Georgia
  - Atlanta, Georgia, United States, 30303
    - Grady Memorial Hospital
  - Atlanta, Georgia, United States, 30309
    - Piedmont Heart Institute
  - Atlanta, Georgia, United States, 30309
    - Piedmont Heart Institute 1
  - Augusta, Georgia, United States, 30912
    - Augusta University
  - Columbus, Georgia, United States, 31904
    - Columbus Regional Research Institute
  - Cumming, Georgia, United States, 30041
    - Atlanta Heart Specialists
  - Gainesville, Georgia, United States, 30501
    - Northeast Georgia Heart Center
  - Thomasville, Georgia, United States, 31792
    - Cardiology Consultants of South Georgia Inc
- Hawaii
  - Honolulu, Hawaii, United States, 96813
    - The Queens Medical Center
- Idaho
  - Coeur d'Alene, Idaho, United States, 83814
    - Kootenai Medical Center
- Illinois
  - Chicago, Illinois, United States, 60611
    - Northwestern University
  - Chicago, Illinois, United States, 60612
    - Rush University Medical Center
  - Gurnee, Illinois, United States, 60031
    - Clinical Investigation Specialists
  - Hazel Crest, Illinois, United States, 60429
    - Chicago Medical Research, LLC
  - Naperville, Illinois, United States, 60540
    - Midwest Cardiovascular Institute
  - O'Fallon, Illinois, United States, 62269
    - Prairie Education and Research Cooperative
  - Oak Lawn, Illinois, United States, 60453
    - Advocate Heart Institute
  - Peoria, Illinois, United States, 61636
    - Methodist Medical Center of Illinois
  - Quincy, Illinois, United States, 62301
    - Blessing Hospital
  - Rockford, Illinois, United States, 61107-5059
    - OSF HealthCare Cardiovascular Institute
  - Springfield, Illinois, United States, 62702
    - Springfield Clinic 1st
- Indiana
  - Bloomington, Indiana, United States, 47402
    - Bloomington Hospital
  - Indianapolis, Indiana, United States, 46260
    - St. Vincent Medical Group, Inc.
  - Muncie, Indiana, United States, 47303
    - IU Health Ball Memorial Hospital
- Kansas
  - Kansas City, Kansas, United States, 66160
    - University of Kansas Medical Center
- Kentucky
  - Crittenden, Kentucky, United States, 41030
    - St. Elizabeth Physicians
  - Louisville, Kentucky, United States, 40202
    - Kentuckyone Health Neurology Associates
  - Owensboro, Kentucky, United States, 42303
    - Owensboro Medical Practice
- Louisiana
  - Alexandria, Louisiana, United States, 71301
    - Cambridge Medical Trials
  - Bossier City, Louisiana, United States, 71111
    - Grace Research, LLC - Bossier City
  - Chalmette, Louisiana, United States, 70043
    - Medical Research Specialists
  - Houma, Louisiana, United States, 70360
    - Cardiovascular Institute of the South
  - New Orleans, Louisiana, United States, 70112
    - Tulane University School of Medicine
  - New Orleans, Louisiana, United States, 70121
    - Ochsner Health System
  - Shreveport, Louisiana, United States, 71103
    - Louisiana State University Health Sciences Center
  - Shreveport, Louisiana, United States, 71115
    - Pierremont Cardiology
  - West Monroe, Louisiana, United States, 71291
    - Clinical Trials of America 1
- Maryland
  - Annapolis, Maryland, United States, 21401
    - Luminis Health Anne Arundel Medical Center
  - Bethesda, Maryland, United States, 20814
    - Suburban Hospital
  - Columbia, Maryland, United States, 21044
    - Johns Hopkins University
  - Rockville, Maryland, United States, 20850
    - Shady Grove Office
  - Salisbury, Maryland, United States, 21804
    - Tidal Health Peninsula Regional Inc.
  - Towson, Maryland, United States, 21204
    - Spectrum Clinical Research, Inc.
- Michigan
  - Ann Arbor, Michigan, United States, 48109
    - University of Michigan
  - Flint, Michigan, United States, 48503
    - Flint Clinical Research
  - Lansing, Michigan, United States, 48912
    - Sparrow Clinical Research Institute
  - Petoskey, Michigan, United States, 49770
    - Michigan Heart & Vascular Institute
  - Southgate, Michigan, United States, 48195
    - Revival Research Institute LLC
  - Troy, Michigan, United States, 48085
    - Oakland Medical Research
  - Ypsilanti, Michigan, United States, 48197
    - Trinity Health Michigan d b a Michigan Heart
- Minnesota
  - Bloomington, Minnesota, United States, 55426
    - HealthPartners Institute
  - Duluth, Minnesota, United States, 55805
    - Essentia Health SMDC
  - Maplewood, Minnesota, United States, 55109
    - Fairview Health System
- Mississippi
  - Jackson, Mississippi, United States, 39202
    - Mississippi Baptist Health Systems
  - Olive Branch, Mississippi, United States, 38654
    - Olive Branch Family Medical Center
  - Tupelo, Mississippi, United States, 38801
    - Cardiology Associates of North Mississippi
- Missouri
  - Columbia, Missouri, United States, 65211
    - The Curators of the University of Missouri on behalf of University of Missouri Health Care
  - St Louis, Missouri, United States, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, United States, 63136
    - St. Louis Heart and Vascular
- New Jersey
  - Bridgewater, New Jersey, United States, 08807
    - Advanced Heart Care, LLC
  - Haddon Heights, New Jersey, United States, 08035
    - Cardiovascular Associates of the Delaware Valley
  - Marlton, New Jersey, United States, 08053
    - Virtua Medical Group, PA
  - Ridgewood, New Jersey, United States, 07450
    - The Valley Hospital
  - Teaneck, New Jersey, United States, 07666
    - Holy Name Medical Center
- New York
  - Cortlandt Manor, New York, United States, 10567
    - NYU Hudson Valley Cardiology
  - Jamaica, New York, United States, 11418
    - Jamaica Hospital Medical Center
  - Kingston, New York, United States, 12401
    - Westchester Medical Center Advanced Physician Services PC
  - Laurelton, New York, United States, 11413
    - Laurelton Heart Specialist, PC
  - Middletown, New York, United States, 10941
    - Crystal Run Healthcare LLP
  - Mineola, New York, United States, 11501
    - NYU Langone Hospital Long Island
  - New York, New York, United States, 10021
    - Weill Cornell Medical College
  - New York, New York, United States, 10075
    - Lenox Hill Hospital
  - The Bronx, New York, United States, 10469
    - Cardiac Care & Vascular Medicine, PLLC
- North Carolina
  - Asheville, North Carolina, United States, 28803
    - Asheville Cardiology Associates
  - Greensboro, North Carolina, United States, 27405
    - Guilford Neurologic Associates
  - Lenoir, North Carolina, United States, 28645
    - Clinical Trials of America
  - Pinehurst, North Carolina, United States, 28374
    - Pinehurst Medical Clinic Inc
  - Raleigh, North Carolina, United States, 27607
    - Rex Hospital
  - Sanford, North Carolina, United States, 27330
    - Sanford Cardiology
  - Wilmington, North Carolina, United States, 28401
    - Wilmington Health Associates
- North Dakota
  - Minot, North Dakota, United States, 58701
    - Trinity Medical Group
- Ohio
  - Akron, Ohio, United States, 44304
    - Summa Health System
  - Cincinnati, Ohio, United States, 45219
    - The Lindner Clinical Trial Center
  - Cleveland, Ohio, United States, 44109
    - The MetroHealth System
  - Cleveland, Ohio, United States, 44106
    - Louis Stokes Cleveland VA Med Ctr
  - Dayton, Ohio, United States, 45414
    - Dayton Heart Center
  - Maumee, Ohio, United States, 43537
    - Advanced Medical Research
  - Springfield, Ohio, United States, 45505
    - The Heart House
  - Zanesville, Ohio, United States, 43701
    - Genesis HealthCare System
- Oklahoma
  - Bartlesville, Oklahoma, United States, 74006
    - Ascension Medical Group - St. John Clinic Infectious Disease
  - Oklahoma City, Oklahoma, United States, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, United States, 73120
    - Oklahoma Heart Hospital
  - Oklahoma City, Oklahoma, United States, 73135
    - South Oklahoma Heart Research
  - Tulsa, Oklahoma, United States, 74104
    - St John Health System Inc
- Oregon
  - Portland, Oregon, United States, 97225
    - Providence Heart Clinic
- Pennsylvania
  - Chambersburg, Pennsylvania, United States, 17201
    - Chambersburg Hospital
  - Erie, Pennsylvania, United States, 16507
    - Hamot Medical Center
  - Newport, Pennsylvania, United States, 17074
    - Capital Area Research
  - Philadelphia, Pennsylvania, United States, 19104
    - Penn Presbyterian Medical Center
  - Pittsburgh, Pennsylvania, United States, 15240
    - VA Pittsburgh Healthcare System
  - Pittsburgh, Pennsylvania, United States, 15213
    - Hudson Valley Cardiovascular Practice, PC
  - Sayre, Pennsylvania, United States, 18840
    - Donald Guthrie Foundation
  - Scranton, Pennsylvania, United States, 18510
    - Geisinger Medical Center
  - Yardley, Pennsylvania, United States, 19067
    - Cardiology Consultants of Philadelphia
  - York, Pennsylvania, United States, 17403-3676
    - York Hospital
- South Carolina
  - Anderson, South Carolina, United States, 29621
    - AnMed Health
  - Anderson, South Carolina, United States, 29621
    - Internal Medicine Associates of Anderson
  - Columbia, South Carolina, United States, 29204
    - MUSC Health Heart Vascular Columbia Medical Park DT III
  - Greenville, South Carolina, United States, 29607
    - St. Francis Physician Services, Inc, DBA Upstate Cardiology Research
- South Dakota
  - Rapid City, South Dakota, United States, 57701
    - Black Hills Cardiovascular Research
- Tennessee
  - Jackson, Tennessee, United States, 38301
    - Jackson Madison County General Hospital
  - Jackson, Tennessee, United States, 38301
    - Jackson Clinic
  - Johnson, Tennessee, United States, 37604
    - Wellmont CVA Heart Institute
  - Kingsport, Tennessee, United States, 37660
    - Holston Medical Group
  - Knoxville, Tennessee, United States, 37923-4310
    - East Tennessee Heart Consultants
  - Nashville, Tennessee, United States, 37205
    - Saint Thomas Health
  - Powell, Tennessee, United States, 37849
    - Cardiovascular Associates
- Texas
  - Amarillo, Texas, United States, 79109
    - PharmaTex Research
  - Amarillo, Texas, United States, 79124
    - Amarillo Heart Clinical Research Institute
  - Austin, Texas, United States, 78705
    - Ascension Texas Cardiovascular
  - Dallas, Texas, United States, 75231
    - Texas Health Dallas
  - Dallas, Texas, United States, 75204
    - Baylor Research Institute
  - Fort Worth, Texas, United States, 76104
    - Plaza Medical Center of Fort Worth
  - Houston, Texas, United States, 77030
    - Baylor College of Medicine
  - Houston, Texas, United States, 77024
    - PrimeCare Medical Group
  - Houston, Texas, United States, 77002
    - East Texas Cardiology, PA
  - Houston, Texas, United States, 77077
    - Novel Research LLC
  - Katy, Texas, United States, 77493
    - West Houston Area Clinical Trial Consultants LLC
  - Kingwood, Texas, United States, 77339
    - Texas Cardiology Research Center
  - Odessa, Texas, United States, 79761
    - Odessa Heart Institute
  - San Antonio, Texas, United States, 78215
    - Sun Research Institute
  - Sugar Land, Texas, United States, 77479
    - Southwest Medical Clinic
  - Tomball, Texas, United States, 77375
    - Northwest Houston Clinical Research
  - Waco, Texas, United States, 76712
    - Baylor Scott and White Research Institute
- Utah
  - Farmington, Utah, United States, 84025
    - Alpine Research Organization
- Virginia
  - Burke, Virginia, United States, 22015
    - Burke Internal Medicine and Research
  - Roanoke, Virginia, United States, 24014
    - Roanoke Heart Institute PLC
- Washington
  - Everett, Washington, United States, 98201
    - Providence Regional Medical Center Everett
  - Seattle, Washington, United States, 98122
    - Swedish Medical Center
  - Tacoma, Washington, United States, 98405
    - Universal Research Group, LLC
- Wisconsin
  - Wausau, Wisconsin, United States, 54401
    - Wausau Hospital
  - Wauwatosa, Wisconsin, United States, 53226
    - Allegiance Reserach Specialists, LLC

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Minimum age of 18 years
Medically stable and appropriate for chronic antithrombotic treatment
Atrial fibrillation eligible to receive anticoagulation
Participant must satisfy one or both of the following categories of risk factors (a or b): a) one or more of the following risk factors: i) age greater than or equal to 75 years, ii) history of any type of stroke including symptomatic stroke of any kind. b) two or more of the following risk factors: i) age between 65 and 74 years, ii) hypertension, iii) diabetes mellitus, iv) atherosclerotic vascular disease, v) heart failure

Exclusion Criteria:

Hemodynamically significant valve disease or those with valve disease that will potentially require surgical valve replacement during the study
Any condition other than AF that requires chronic anticoagulation

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Double

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Milvexian Participants will receive milvexian 100 milligrams (mg) orally, twice daily and placebo that matches apixaban beginning on Day 1 through end of treatment (EOT). Participants after the EOT visit may have an option to receive open-label apixaban at the appropriate dose (5 mg or 2.5 mg, twice daily), for which the sponsor provides a 30-day supply.	Drug: Milvexian Milvexian will be administered orally. Drug: Placebo Milvexian matching milvexian placebo will be administered orally.
Active Comparator: Apixaban Participants will receive a placebo that matches milvexian and a capsule containing apixaban 5 mg or 2.5 mg orally, twice daily. Participants after the EOT visit may have an option to receive open-label apixaban (5 mg or 2.5 mg, twice daily) at the appropriate dose, for which the sponsor provides a 30-day supply.	Drug: Apixaban Apixaban will be administered orally. Drug: Apixaban Placebo Apixaban matching apixaban placebo will be administered orally.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to the First Occurrence of Composite Endpoint of Stroke and Non-central nervous system (CNS) Systemic Embolism Time Frame: Up to 4 years	Time to the first occurrence of composite endpoint of stroke and non-CNS systemic embolism will be reported.	Up to 4 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to the First Occurrence of International Society of Thrombosis and Hemostasis (ISTH) Major Bleeding Time Frame: Up to 4 years	Time to the first occurrence of ISTH major bleeding will be reported.	Up to 4 years
Time to the First Occurrence of the Composite of ISTH Major and Clinically Relevant Non-major (CRNM) Bleeding Time Frame: Up to 4 years	Time to the first occurrence of the composite of ISTH major and CRNM bleeding will be reported.	Up to 4 years
Time to the First Occurrence of Composite Endpoint of Cardiovascular (CV) Death, Myocardial Infarction (MI), Stroke, and Non-CNS Systemic Embolism Time Frame: Up to 4 years	Time to the first occurrence of composite endpoint of CV death, MI, stroke, and non-CNS systemic embolism will be reported.	Up to 4 years
Time to CV Death Time Frame: Up to 4 years	Time to CV death will be reported.	Up to 4 years
Time to the First Occurrence of Composite Endpoint of All-cause Death, MI, Stroke and Non-CNS Systemic Embolism Time Frame: Up to 4 years	Time to the first occurrence of composite endpoint of all-cause death, MI, stroke and Non-CNS systemic embolism will be reported.	Up to 4 years
Time to the First Occurrence of Composite Endpoint of CV Death, MI, Stroke, Acute Limb Ischemia (ALI), and Urgent Hospitalization for Vascular cause of Ischemic Nature Time Frame: Up to 4 years	Time to the first occurrence of composite endpoint of CV death, MI, stroke, ALI [any unanticipated revascularization or amputation of ischemic limb]), and urgent hospitalization for vascular cause of ischemic nature (including deep vein thrombosis [DVT] and pulmonary embolism [PE]) will be reported.	Up to 4 years
Time to the First Occurrence of Composite Endpoint of Stroke, Non-CNS Systemic Embolism and ISTH Major Bleeding Time Frame: Up to 4 years	Time to the first occurrence of composite endpoint of stroke, non-CNS systemic embolism and ISTH major bleeding will be reported.	Up to 4 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Janssen Research & Development, LLC

Collaborators

Bristol-Myers Squibb

Investigators

Study Director: Janssen Research & Development, LLC Clinical Trial, Janssen Research & Development, LLC

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Jain SS, Mahaffey KW, Pieper KS, Shimizu W, Potpara T, Ruff CT, Kamel H, Lewis BS, Cornel JH, Kowey PR, Horrow J, Strony J, Plotnikov AN, Li D, Weng S, Donahue J, Gibson CM, Steg PG, Mehran R, Weitz JI, Johnston SC, Hankey GJ, Harrington RA, Lam CSP; LIBREXIA AF Trial Investigators and Committees. Milvexian vs apixaban for stroke prevention in atrial fibrillation: The LIBREXIA atrial fibrillation trial rationale and design. Am Heart J. 2024 Nov;277:145-158. doi: 10.1016/j.ahj.2024.08.011. Epub 2024 Aug 29.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 11, 2023

Primary Completion (Estimated)

October 31, 2026

Study Completion (Estimated)

October 31, 2026

Study Registration Dates

First Submitted

February 24, 2023

First Submitted That Met QC Criteria

February 24, 2023

First Posted (Actual)

March 7, 2023

Study Record Updates

Last Update Posted (Actual)

May 8, 2026

Last Update Submitted That Met QC Criteria

May 7, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

CR109220
70033093AFL3002 (Other Identifier: Janssen Research & Development, LLC)
2022-501419-15-00 (Registry Identifier: EUCT number)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

The data sharing policy of Johnson & Johnson Innovative Medicine is available at innovativemedicine.jnj.com/our-innovation/clinical-trials/transparency. As noted on this site, requests for access to the study data can be submitted through Yale Open Data Access (YODA) Project site at yoda.yale.edu

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Collaborators

Investigators

Publications and helpful links

General Publications

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Estimated)

Study Completion (Estimated)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Atrial Fibrillation

Clinical Trials on Milvexian

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