A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation (LIBREXIA-AF)

April 23, 2024 updated by: Janssen Research & Development, LLC

A Phase 3, Randomized, Double-Blind, Double-Dummy, Parallel Group, Active-Controlled Study to Evaluate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, Versus Apixaban in Participants With Atrial Fibrillation

The purpose of this study is to evaluate if milvexian is at least as effective as apixaban for reducing the risk of the composite stroke and non-central nervous system (CNS) systemic embolism.

Study Overview

Study Type

Interventional

Enrollment (Estimated)

15500

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

      • Buenos Aires, Argentina, C1187AAN
        • Recruiting
        • Sanatorio Finochietto
      • Buenos Aires, Argentina, C1440CFD
        • Recruiting
        • CEMEDIC
      • Ciudad Autonoma Buenos Aires, Argentina, 1428
        • Recruiting
        • Instituto Cardiovascular de Buenos Aires
      • Ciudad Autonoma Buenos Aires, Argentina, C1093AAS
        • Recruiting
        • Fundacion Favaloro
      • Ciudad Autonoma Buenos Aires, Argentina, 1425
        • Recruiting
        • Consultorios Asociados de Endocrinología e Investigación Clínica Aplicada
      • Ciudad Autonoma Buenos Aires, Argentina, 1406
        • Recruiting
        • Consultorio Dr. Litvak Bruno
      • Ciudad Autonoma Buenos Aires, Argentina, C1430CKE
        • Recruiting
        • Glenny Corp. S.A. - Bioclinica Argentina
      • Ciudad Autonoma de Buenos Aires, Argentina, C1061AAS
        • Recruiting
        • CIPREC
      • Ciudad Autonoma de Buenos Aires, Argentina, 1060
        • Recruiting
        • Cedic Centro de Investigaciones Clinicas
      • Ciudad De Buenos Aires, Argentina, C1430EGF
        • Recruiting
        • Clínica Adventista Belgrano
      • Ciudad de Mendoza, Argentina, 5500
        • Recruiting
        • Fundacion Scherbovsky
      • Cordoba, Argentina, 5000
        • Recruiting
        • Clínica Colombo
      • Godoy Cruz, Argentina, 5501
        • Recruiting
        • CIPADI
      • Mar del Plata, Argentina, B7600FYK
        • Recruiting
        • Centro de Investigaciones Médicas Mar del Plata
      • Rosario, Argentina, S2000SDV
        • Recruiting
        • Sanatorio Parque
      • Rosario, Argentina, S2000BIF
        • Recruiting
        • Instituto de Investigaciones Clinicas de Rosario
      • San Juan, Argentina, 5400
        • Recruiting
        • Investigaciones Clinicas Cuyo
      • San Miguel de Tucuman, Argentina, T4000ICL
        • Recruiting
        • Investigaciones Clinicas Tucuman
      • Santa Fe, Argentina, 3000
        • Recruiting
        • Centro de Investigaciones Clinicas del Litoral
      • Venado Tuerto, Argentina, S2600KUE
        • Recruiting
        • Sanatorio San Martin
      • Adelaide, Australia, 5042
        • Recruiting
        • Flinders Medical Centre
      • Brisbane, Australia, 4066
        • Recruiting
        • Advara HeartCare Wesley
      • Concord, Australia, 2139
        • Recruiting
        • Concord Repatriation General Hospital
      • Frankston, Australia, 3199
        • Recruiting
        • Peninsula Heart Center
      • Herston, Australia, 4029
        • Recruiting
        • Royal Brisbane and Women's Hospital
      • Joondalup, Australia, 6027
        • Recruiting
        • GenesisCare Joondalup-Shenton House
      • Kotara, Australia, 2289
        • Recruiting
        • Novatrials
      • Leabrook, Australia, 5068
        • Recruiting
        • GenesisCare
      • Milton, Australia, 4064
        • Recruiting
        • CORE Research Group
      • Tarragindi, Australia, 4121
        • Recruiting
        • Brisbane Health Connect
      • Aalst, Belgium, 9300
        • Recruiting
        • Algemeen Stedelijk Ziekenhuis
      • Antwerpen, Belgium, 2020
        • Recruiting
        • ZNA Middelheim
      • Arlon, Belgium, 6700
        • Recruiting
        • CSL Arlon
      • Bruxelles, Belgium, 1070
        • Recruiting
        • CUB Hôpital Erasme
      • Dendermonde, Belgium, 9200
        • Recruiting
        • AZ Sint-Blasius
      • Edegem, Belgium, 2650
        • Recruiting
        • UZA
      • Herk-de-Stad, Belgium, 3540
        • Recruiting
        • Jessa Ziekenhuis - Campus St.-Ursula
      • La Louvière, Belgium, 7100
        • Recruiting
        • Chu Tivoli
      • Leuven, Belgium, 3000
        • Recruiting
        • UZ Leuven
      • Mechelen, Belgium, 97770
        • Recruiting
        • Az Sint-Maarten
      • Mol, Belgium, 2400
        • Recruiting
        • Heilig Hart ziekenhuis Lier
      • Roeselare, Belgium, 8800
        • Recruiting
        • AZ Delta vzw
      • Blagoevgrad, Bulgaria, 2700
        • Recruiting
        • MHAT Puls
      • Dimitrovgrad, Bulgaria, 6400
        • Recruiting
        • Medical Center Diamedical
      • Dimitrovgrad, Bulgaria, 6400
        • Recruiting
        • MHAT St. Ekaterina
      • Dupnitsa, Bulgaria, 2600
        • Recruiting
        • Medical Centre Asklepii OOD
      • Gabrovo, Bulgaria, 5300
        • Recruiting
        • Multiprofile Hospital for Active Treatment Dr. Tota Venkova
      • Haskovo, Bulgaria, 6300
        • Recruiting
        • Multiprofile Hospital for Active Treatment - Haskovo
      • Kardzhali, Bulgaria, 6600
        • Recruiting
        • Medical center Rodopimed EOOD
      • Pleven, Bulgaria, 5800
        • Recruiting
        • Medical Center Medconsult-Pleven
      • Pleven, Bulgaria, 5800
        • Recruiting
        • UMHAT 'Dr. Georgi Stranski', EAD
      • Pleven, Bulgaria, 5800
        • Recruiting
        • UMHAT 'Heart and Brain Center for Excellence'
      • Ruse, Bulgaria, 7013
        • Recruiting
        • MC Rusemed ltd
      • Ruse, Bulgaria, 7000
        • Recruiting
        • Medical Center- Prolet Ltd
      • Sevlievo, Bulgaria, 5402
        • Recruiting
        • Medical Center Unimed Eood
      • Sofia, Bulgaria, 1309
        • Recruiting
        • Multiprofile Hospital For Active Treatment National Cardiology Hospital, Ead
      • Sofia, Bulgaria, 1510
        • Recruiting
        • Medical Center Hera EOOD
      • Sofia, Bulgaria, 1680
        • Recruiting
        • DCC Convex EOOD
      • Sofia, Bulgaria, 1431
        • Recruiting
        • UMHAT Prof. Dr. Aleksandar Chirkov
      • Sofia, Bulgaria, 1202
        • Recruiting
        • Second Multiprofile Hospital for Active Treatment MHAT - Sofia AD
      • Sofia, Bulgaria, 1431
        • Recruiting
        • Diagnostic Consultation Centre 'Alexandrovska' EOOD
      • Sofia, Bulgaria, 1000
        • Recruiting
        • Individual Ambulatory of Cardiology
      • Sofia, Bulgaria, 1202
        • Recruiting
        • DCC Ascendent EAD
      • Sofia, Bulgaria, 1680
        • Recruiting
        • Medical Centre Kalimat
      • Stara Zagora, Bulgaria, 6003
        • Recruiting
        • UMHAT Prof. Dr. St. Kirkovich AD
      • Stara Zagora, Bulgaria, 6003
        • Recruiting
        • Medical Center ZaraMed
      • Varna, Bulgaria, 9000
        • Recruiting
        • DCC Chaika EOOD
      • Veliko Tarnovo, Bulgaria, 5000
        • Recruiting
        • MHAT Dr Stefan Cherkezov
      • Veliko Tarnovo, Bulgaria, 5000
        • Recruiting
        • Medical Center -Medika Plus
      • Yambol, Bulgaria, 8600
        • Recruiting
        • MHAT Sv. Panteleymon AD
    • Alberta
      • Calgery, Alberta, Canada, T2N 1N4
        • Recruiting
        • The Governers of the University of Calgary
    • British Columbia
      • New Westminster, British Columbia, Canada, V3L 3W4
        • Recruiting
        • Fraser Clinical Trials Inc.
      • Surrey, British Columbia, Canada, V3V 0C6
        • Recruiting
        • Surrey Memorial Hospital
      • Victoria, British Columbia, Canada, V8R 4R2
        • Recruiting
        • Victoria Cardiac Arrhythmia Trials Inc
    • Ontario
      • Brampton, Ontario, Canada, L6Z 4N5
        • Recruiting
        • Brampton Research Assoc
      • Cambridge, Ontario, Canada, N1R 7R1
        • Recruiting
        • Dr. Saul Vizel Cardiac Research Office
      • Mississauga, Ontario, Canada, L4Y 1M3
        • Suspended
        • One Heart Care
      • Oshawa, Ontario, Canada, L1J 2K1
        • Recruiting
        • Dr. James Cha
      • Peterborough, Ontario, Canada, K9J 0B2
        • Recruiting
        • Kawartha Cardiology Clinical Trials
      • Waterloo, Ontario, Canada, N2T 0C1
        • Recruiting
        • CPS Research
    • Quebec
      • Greenfield Park, Quebec, Canada, J4V 2G8
        • Recruiting
        • ViaCar Recherche Clinique Inc
      • Montreal, Quebec, Canada, H2X 0C1
        • Recruiting
        • CHUM - Pavillon B
      • Puerto Varas, Chile, 5551070
        • Recruiting
        • Quantum Research
      • Santiago, Chile, 7500710
        • Recruiting
        • BioMedica Research Group
      • Santiago, Chile
        • Recruiting
        • Sociedad Medica Cardiologica El Llano
      • Santiago, Chile, 8330024
        • Recruiting
        • Centro de Investigacion Clinica Universidad Catolica de Chile CICUC
      • Santiago, Chile, 7500000
        • Recruiting
        • Enroll Spa
      • Santiago, Chile, 7500739
        • Recruiting
        • SMOLAM
      • Temuco, Chile, 4780000
        • Recruiting
        • Centro de Estudios Cardiologicos y de Medicina Interna
      • Temuco, Chile, 4781156
        • Recruiting
        • Centro de Investigacion Clinica del Sur
      • Vina del Mar, Chile, 2520997
        • Recruiting
        • Centro de Estudios Clinicos V Region Ltda
      • Beijing, China, 100853
        • Recruiting
        • Chinese PLA General Hospital
      • Changchun, China, 130021
        • Recruiting
        • The First Hospital of Jilin University
      • Chengdu, China, 610041
        • Recruiting
        • West China Hospital Sichuan University
      • Ganzhou, China, 341000
        • Recruiting
        • Jiangxi Ganzhou Peoples Hospital
      • Guangzhou, China, 510080
        • Recruiting
        • Guangdong Provincial People's Hospital
      • Guangzhou, China, 510280
        • Recruiting
        • Zhujiang Hospital of Southern Medical University
      • Guiyang, China, 550000
        • Recruiting
        • The Affiliated Hospital Of Guizhou Medical University
      • Guiyang, China, 550002
        • Recruiting
        • GuiZhou Privicial Peoples Hospital
      • Hangzhou, China, 310006
        • Recruiting
        • Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine
      • Huhehaote, China, 010017
        • Recruiting
        • Inner Mongolia People's Hospital
      • Jinan, China, 250012
        • Recruiting
        • Qilu Hospital of Shandong University
      • Jining, China, 272011
        • Recruiting
        • Shandong Jining No.1 People's Hospital
      • Lanzhou, China, 730030
        • Recruiting
        • Lanzhou University Second Hospital
      • Nanchang, China, 330006
        • Recruiting
        • The Second Affiliatde Hospital To Nanchang University
      • Nanchang, China, 330006
        • Recruiting
        • Jiangxi Provincial Peoples Hospital
      • Shanghai, China, 200032
        • Recruiting
        • Zhongshan Hospital Fudan University
      • Shenyang, China, 110004
        • Recruiting
        • Shengjing Hospital of China Medical University
      • Taiyuan, China, 030013
        • Recruiting
        • Shanxi Cardiovascular Hospital
      • Tianjin, China, 300121
        • Recruiting
        • Tianjin People's Hospital
      • Wenzhou, China, 325000
        • Recruiting
        • Wenzhou Peoples Hospital
      • Wuhan, China, 430014
        • Recruiting
        • The Central Hospital of Wuhan
      • Xinxiang, China, 453003
        • Recruiting
        • The Third Affiliated Hospital of Xinxiang Medical university
      • Yantai, China, 264000
        • Recruiting
        • Yantai Yuhuangding Hospital
      • Zhanjiang, China, 524001
        • Recruiting
        • Affiliated Hospital of Guangdong Medical University
      • Zhengzhou, China, 450016
        • Recruiting
        • The 7th Peoples Hospital of Zhengzhou
      • Dubrovnik, Croatia, 20000
        • Recruiting
        • General Hospital Dubrovnik
      • Krapinske Toplice, Croatia, 49217
        • Recruiting
        • Special Hospital for medical rehabilitation
      • Varazdin, Croatia, 42000
        • Recruiting
        • OB Varazdin
      • Zagreb, Croatia, 10000
        • Recruiting
        • University Hospital Dubrava
      • Zagreb, Croatia, 10000
        • Recruiting
        • Poliklinika Solmed
      • Bilovec, Czechia, 743 01
        • Recruiting
        • HUMANITAS spol. s r.o.
      • Brandys nad Labem, Czechia, 25001
        • Recruiting
        • Interni ordinace s.r.o
      • Brandýs nad Labem, Czechia, 250 01
        • Recruiting
        • MEDICUS SERVICES s.r.o.
      • Brno, Czechia, 65691
        • Recruiting
        • Fakultni nemocnice u sv. Anny v Brne
      • Brno, Czechia, 636 00
        • Recruiting
        • Vojenska nemocnice Brno
      • Broumov, Czechia, 550 01
        • Recruiting
        • EDUMED s.r.o.
      • Ceske Budejovice, Czechia, 37001
        • Recruiting
        • Nemocnice Ceske Budejovice, a.s.
      • Chomutov, Czechia, 430 02
        • Recruiting
        • Ordinace pro choroby srdce s.r.o.
      • Jablonec nad Nisou, Czechia, 46601
        • Recruiting
        • Kardiologie KarMa s.r.o
      • Kromeriz, Czechia, 767 01
        • Recruiting
        • Lunacor s.r.o. - Ambulance kardiologie Centrum pro choroby srdce a cev
      • Litovel, Czechia, 78401
        • Recruiting
        • Kardio Interna s.r.o.
      • Olomouc, Czechia, 77900
        • Recruiting
        • Fakultni nemocnice Olomouc
      • Olomouc, Czechia, 77900
        • Recruiting
        • PreventaMed, s.r.o.
      • Olomouc, Czechia, 779 00
        • Recruiting
        • MUDr. Zdenek Vomacka kardiologie a interna s.r.o.
      • Ostrava Poruba, Czechia, 708 52
        • Recruiting
        • Cerebrovaskularni poradna s.r.o.
      • Pardubice, Czechia, 530 03
        • Recruiting
        • Pardubicka krajska nemocnice a.s.
      • Prague, Czechia, 158 00
        • Recruiting
        • MUDr. Eva Zídkova
      • Praha 1, Czechia, 110 00
        • Recruiting
        • Nemocnice Na Frantisku
      • Praha 10, Czechia, 100 34
        • Recruiting
        • Fakultni nemocnice Kralovske Vinohrady
      • Praha 10, Czechia, 101 00
        • Recruiting
        • MUDr. Jan KVASNICKA CSc. Angiologie kardiologie a interna
      • Pribram, Czechia, 26101
        • Recruiting
        • Centrum klinickeho vyzkumu
      • Slany, Czechia, 274 01
        • Recruiting
        • Nemocnice Slany, interni oddeleni
      • Trutnov, Czechia, 541 01
        • Recruiting
        • Interni ambulance
      • Uherske Hradiste, Czechia, 68601
        • Recruiting
        • Interni ambulance Dr.Stanislav Zemek
      • Zlin, Czechia, 760 01
        • Recruiting
        • Cardio Research s r o
      • Aarhus, Denmark, 8200
        • Recruiting
        • Aarhus University Hospital
      • Copenhagen S, Denmark, 2300
        • Recruiting
        • Amager Hospital
      • Herlev, Denmark, 2730
        • Recruiting
        • Gentofte Herlev Hospital
      • Herning, Denmark, 7400
        • Recruiting
        • Herning Regional Hospital
      • Holbæk, Denmark, 4300
        • Recruiting
        • Holbæk Sygehus
      • Hvidovre, Denmark, 2650
        • Recruiting
        • Hvidovre Hospital
      • Slagelse, Denmark, 4200
        • Recruiting
        • Slagelse Sygehus
      • Svendborg, Denmark, 5700
        • Recruiting
        • Odense University Hospital
      • Tallinn, Estonia, 13419
        • Recruiting
        • Dr. Arvo Rosenthal LLC
      • Angers Cedex 9, France, 49933
        • Recruiting
        • CHU Angers - Hôpital Hôtel Dieu
      • Bayonne Cedex, France, 64109
        • Recruiting
        • Centre Hospitalier de la Côte Basque
      • Corbeil Essonnes cedex, France, 91106
        • Recruiting
        • Centre Hospitalier Sud Francilien
      • Creteil, France, 94010
        • Recruiting
        • Hopital Henri Mondor
      • Montauban, France, 82000
        • Recruiting
        • Clinique Du Pont De Chaume
      • Paris, France, 75010
        • Recruiting
        • Hopital Lariboisiere
      • Paris, France, 75018
        • Recruiting
        • Hôpital Bichat - Claude Bernard
      • Paris, France, 75013
        • Recruiting
        • Hopital Broca
      • Paris Cedex 12, France, 75571
        • Recruiting
        • Hôpital Saint-Antoine
      • Poitiers, France, 86000
        • Recruiting
        • CHU Poitiers - Hôpital la Milétrie
      • Rouen, France, 78000
        • Recruiting
        • Clinique Saint-Hilaire - Centre Frédéric Joliot
      • Altenburg, Germany, 04600
        • Recruiting
        • Klinikum Altenburger Land GmbH
      • Bad Friedrichshall, Germany, 74177
        • Recruiting
        • Klinikum am Plattenwald
      • Bad Homburg, Germany, 61348
        • Recruiting
        • Kardiologische Praxis Dr. med. univ. Jungmair
      • Bamberg, Germany, 96049
        • Recruiting
        • Dres. Haas Kirschner Wagner
      • Berlin, Germany, 13509
        • Recruiting
        • Vivantes Humboldt Klinikum
      • Berlin, Germany, 10249
        • Recruiting
        • Vivantes Klinikum im Friedrichshain
      • Berlin, Germany, 12200
        • Recruiting
        • Charite Campus Benjamin Franklin
      • Berlin, Germany, 10559
        • Recruiting
        • Augentagesklinik Spreebogen Berlin GbR
      • Berlin, Germany, 10967
        • Recruiting
        • Vivantes Klinikum Am Urban, Abt. fur Kardiologie
      • Bielefeld, Germany, 33604
        • Recruiting
        • Klinikum Bielefeld
      • Bonn-Beuel, Germany, 53225
        • Recruiting
        • GFO Kliniken Bonn, Betriebsstaette St. Marien
      • Dachau, Germany, 85221
        • Recruiting
        • Medizinisches Versorgungszentrum (MVZ) Dachau
      • Deggingen, Germany, 73326
        • Recruiting
        • Gemeinschaftspraxis
      • Dessau-Rosslau, Germany, 06846
        • Recruiting
        • Praxis-Dr. Frank Menzel
      • Dresden, Germany, 01067
        • Recruiting
        • Städtisches Klinikum Dresden
      • Dresden, Germany, 01099
        • Recruiting
        • FAZ Dresden-Neustadt GbR
      • Dresden, Germany, 01277
        • Recruiting
        • Hausärztlich-Kardiologisches MVZ Am Felsenkeller GmbH
      • Elsterwerda, Germany, 04910
        • Recruiting
        • ZKS Südbrandenburg GMBH
      • Essen, Germany, 45355
        • Recruiting
        • Medizentrum Essen Borbeck
      • Essen, Germany, 45355
        • Recruiting
        • Gemeinschaftspraxis Dres. Hagemann und Breiderhoff
      • Essen, Germany, 45355
        • Recruiting
        • Studienzentrum
      • Frankfurt, Germany, 60596
        • Recruiting
        • ClinPhenomics GmbH Co KG Studienzentrum Frankfurt
      • Freiburg, Germany, 79106
        • Recruiting
        • Universitaetsklinikum Freiburg
      • Hamburg, Germany, 22527
        • Recruiting
        • Medizinisches Versorgungszentrum Prof. Mathey, Prof. Schofer GmbH
      • Hamburg, Germany, 20099
        • Recruiting
        • ClinPhenomics GmbH Co KG Studienzentrum Frankfurt
      • Hamburg, Germany, 22415
        • Recruiting
        • Praxis Dr. Cornelia Schiewe
      • Kiel, Germany, 24105
        • Recruiting
        • Universitaetsklinikum Schleswig-Holstein Campus Kiel
      • Ludwigshafen, Rp, Germany, 67063
        • Recruiting
        • Klinikum Ludwigshafen
      • Mainz, Germany, 55131
        • Recruiting
        • Katholisches Klinikum Mainz; Innere Medizin I- Kardiologie
      • Mannheim, Germany, 68165
        • Recruiting
        • Praxis Für Pneumologie Und Allergologie
      • Nuremberg, Germany, 90402
        • Recruiting
        • GP Dr. Haggenmiller PD Dr. Michael Jeserich
      • Papenburg, Germany, 26871
        • Recruiting
        • Kardiologische Praxis Papenburg
      • Stuhr, Germany, 28816
        • Recruiting
        • Praxisgemeinschaft Stuhr-Brinkum
      • Wermsdorf, Germany, 04779
        • Recruiting
        • Kardiologische Praxis
      • Worms, Germany, 67550
        • Recruiting
        • Stadtkrankenhaus Worms
      • Baja, Hungary, 6500
        • Recruiting
        • Lausmed Egeszsegugyi es Szolg. Kft.
      • Balatonfured, Hungary, 8230
        • Recruiting
        • DRC Gyogyszervizsgalo Kozpont Kft
      • Bekescsaba, Hungary, 5600
        • Recruiting
        • Belgyogyaszati es Kardiologiai Maganrendelo
      • Budapest, Hungary, 1088
        • Recruiting
        • Semmelweis Egyetem
      • Budapest, Hungary, 1152
        • Recruiting
        • Uno Medical Trials Ltd.
      • Budapest, Hungary, 1036
        • Recruiting
        • Óbudai Egészségügyi Centrum Kft
      • Budapest, Hungary, 1122
        • Recruiting
        • Semmelweis Egyetem Városmajori Szív- és Érgyógyászati Klinika
      • Budapest, Hungary, 1132
        • Recruiting
        • Med-Tima Kft
      • Budapest, Hungary, 1051
        • Recruiting
        • Belvaros-Lipotvaros Egeszsegugyi Szolgalat
      • Budapest, Hungary, 1085
        • Recruiting
        • Szt. Rokus Hosp
      • Budapest, Hungary, 1097
        • Recruiting
        • Del Pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet Szent Laszlo Telephely
      • Debrecen, Hungary, 4032
        • Recruiting
        • Debreceni Egyetem
      • Debrecen, Hungary, 4025
        • Recruiting
        • Belinus Orvosi es Szamtech. Bt.
      • Gyongyos, Hungary, 3200
        • Recruiting
        • Bugát Pál Kórház
      • Hatvan, Hungary, 3000
        • Recruiting
        • BKS Research Kft
      • Hodmezovasarhely, Hungary, 6800
        • Recruiting
        • Csongrád Megyei Egészségügyi Ellátó Központ Hódmezővásárhely
      • Kaposvar, Hungary, 7400
        • Recruiting
        • Somogy Megyei Kaposi Mór Oktató Kórház
      • Miskolc, Hungary, 3530
        • Recruiting
        • IPR Hungary Kft
      • Mosonmagyarovar, Hungary, 9200
        • Recruiting
        • TaNaMed Kft.
      • Nyiregyhaza, Hungary, H-4405
        • Recruiting
        • Borbanya Praxis Eu. Kft.
      • Oroshaza, Hungary, 5900
        • Recruiting
        • Dr. Nagy Laszlo Kardiologiai Maganrendeles
      • Pecs, Hungary, 7623
        • Recruiting
        • Coromed-Smo Kft
      • Szeged, Hungary, 6725
        • Recruiting
        • Szegedi Tudományegyetem
      • Szekesfehervar, Hungary, 8000
        • Recruiting
        • Vita Verum Medical Egeszsegugyi Szolgaltato Bt
      • Szolnok, Hungary, 5000
        • Recruiting
        • Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointez
      • Zalaegerszeg, Hungary, 8900
        • Recruiting
        • Óbudai Egészségügyi Centrum Kft
      • Zalaegerszeg, Hungary, H8900
        • Recruiting
        • Zala Megyei Szent Rafael Kórház
      • Afula, Israel, 18101
        • Recruiting
        • Haemek Medical Center
      • Hadera, Israel, 3810101
        • Recruiting
        • Hillel Yaffe Medical Center
      • Haifa, Israel, 3436212
        • Recruiting
        • Carmel Medical Center
      • Haifa, Israel, 31048
        • Recruiting
        • Bnai Zion Medical Center
      • Jerusalem, Israel, 9124001
        • Recruiting
        • Hadassah Medical Center
      • Kfar-Sava, Israel, 4428164
        • Recruiting
        • Meir Medical Center
      • Petah Tikva, Israel, 49100
        • Recruiting
        • Rabin Medical Center
      • Ramat Gan, Israel, 5262001
        • Recruiting
        • Chaim Sheba Medical Center
      • Rechovot, Israel, 7610001
        • Recruiting
        • Kaplan Medical Center
      • Rishon Lezion, Israel, 70300
        • Recruiting
        • Assaf Harofeh Medical Center
      • Yerushalayim, Israel, 22100
        • Recruiting
        • Hadassah University Hospita - Ein Kerem
      • Arezzo, Italy, 52100
        • Recruiting
        • Ospedale San Donato - ASL 8 Arezzo
      • Bergamo, Italy, 24125
        • Recruiting
        • Cliniche Humanitas Gavazzeni
      • Bologna, Italy, 40138
        • Recruiting
        • Azienda Opedaliero-Universitaria Policlinico Sant'orsola Malpighi di Bologna
      • Caserta, Italy, 81100
        • Recruiting
        • AORN Sant'Anna e San Sebastiano
      • Catania, Italy, 95124
        • Recruiting
        • P.O. Vittorio Emanuele Azienda Ospedaliero Universitaria 'Policlinico Vittorio Emanuele'
      • Catanzaro, Italy, 88100
        • Recruiting
        • AO di Catanzaro Pugliese Ciaccio
      • Ferrara, Italy, 44124
        • Recruiting
        • Arcispedale S. Anna Ferrara
      • Lecco, Italy, 23900
        • Recruiting
        • Ospedale Manzoni
      • Massa, Italy, 54100
        • Recruiting
        • Fondazione Toscana Gabriele Monasterio CNR
      • Milano, Italy, 20122
        • Recruiting
        • Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
      • Milano, Italy, 20162
        • Recruiting
        • A O Ospedale Niguarda Ca Granda
      • Monza, Italy, 20052
        • Recruiting
        • Azienda Socio Sanitaria Territoriale di Monza Presidio San Gerardo
      • Pavia, Italy, 27100
        • Recruiting
        • Fondazione IRCCS Policlinico San Matteo
      • Pisa, Italy, 56126
        • Recruiting
        • A. O.U. Pisana Ospedale di Cisanello
      • Roma, Italy, 00161
        • Recruiting
        • AOU Policlinico Umberto I
      • Roma, Italy, 00152
        • Recruiting
        • A.O. San Camillo Forlanini
      • Roma, Italy, 00168
        • Recruiting
        • Fondazione Policlinico Universitario A Gemelli IRCCS
      • Roma, Italy, 00157
        • Recruiting
        • Ospedale Sandro Pertini di Roma Reparto Emodinamica
      • Rozzano, Italy, 20089
        • Recruiting
        • Istituto Clinico Humanitas
      • Sassari, Italy, 07100
        • Recruiting
        • P.O. Ss. Annunziata
      • Torrette Di Ancona, Italy, 60126
        • Recruiting
        • Azienda Ospedaliero Universitaria Ospedali Riuniti
      • Aichi, Japan, 471-8513
        • Recruiting
        • Toyota Memorial Hospital
      • Aichi, Japan, 486-8510
        • Recruiting
        • Kasugai Municipal Hospital
      • Bunkyo-Ku, Japan, 113-8519
        • Recruiting
        • Tokyo Medical And Dental University Hospital
      • Chiba, Japan, 273-8588
        • Recruiting
        • Funabashi Munitiple Medical Center
      • Chiba, Japan, 260 8677
        • Recruiting
        • Chiba University Hospital
      • Chikushino-shi, Japan, 818-8516
        • Recruiting
        • Saiseikai Futsukaichi Hospital
      • Fukuoka, Japan, 810 8563
        • Recruiting
        • National Hospital Organization Kyushu Medical Center
      • Fukuoka, Japan, 805-0050
        • Recruiting
        • Steel Memorial Yawata Hospital
      • Fukuoka, Japan, 819-1104
        • Recruiting
        • Nakamura Cardiovascular Clinic
      • Fukuoka, Japan, 812 8582
        • Recruiting
        • Kyushu University Hospital
      • Funabashi-shi, Japan, 274-8503
        • Recruiting
        • Tokushukai Chiba Tokushukai Hospital
      • Gifu, Japan, 500-8717
        • Recruiting
        • Gifu Prefectural General Medical Center
      • Higashiibaraki-gun, Japan, 311-3193
        • Recruiting
        • National hospital Organization Mito Medical Center
      • Hirosaki-shi, Japan, 036-8562
        • Recruiting
        • Hirosaki University Hospital
      • Hiroshima shi, Japan, 734 8551
        • Recruiting
        • Hiroshima University Hospital
      • Hiroshima-shi, Japan, 734-8530
        • Recruiting
        • Hiroshima Prefectural Hospital
      • Hokkaido, Japan, 053-8567
        • Recruiting
        • Tomakomai City Hospital
      • Hyogo, Japan, 660-8550
        • Recruiting
        • Hyogo Prefectural Amagasaki General Medical Center
      • Isehara, Japan, 259-1193
        • Recruiting
        • Tokai University Hospital
      • Ishikawa, Japan, 920-8650
        • Recruiting
        • National Hospital Organization Kanazawa Medical Center
      • Ishikawa, Japan, 924-0865
        • Recruiting
        • Public Central Hospital of Matto Ishikawa
      • Itabashi Ku, Japan, 173 8606
        • Recruiting
        • Teikyo University Hospital
      • Kagoshima-shi, Japan, 892-0822
        • Recruiting
        • Tenyokai Chuo Clinic
      • Kasuga-shi, Japan, 816-0864
        • Recruiting
        • Fukuoka Tokushukai Hospital
      • Kawasaki-shi, Japan, 212-0021
        • Recruiting
        • Sekishinkai Second Kawasaki Saiwai Clinic
      • Kitakyushu-shi, Japan, 802-8555
        • Recruiting
        • Kokura Memorial Hospital
      • Kumamoto, Japan, 860-8556
        • Recruiting
        • Kumamoto University Hospital
      • Kumamoto-shi, Japan, 861-4193
        • Recruiting
        • Saiseikai Kumamoto Hospital
      • Kusatsu-shi, Japan, 525-8585
        • Recruiting
        • Omi Medical Center
      • Kyoto-shi, Japan, 606-8507
        • Recruiting
        • Kyoto University Hospital
      • Matsuyama-shi, Japan, 790-0024
        • Recruiting
        • Ehime Prefectural Central Hospital
      • Mito-shi, Japan, 310-0055
        • Recruiting
        • Seijunkai Mito Hospital
      • Miyazaki, Japan, 885-0002
        • Recruiting
        • Miyakonojo Medical Association Hospital
      • Miyazaki-shi, Japan, 880-2102
        • Recruiting
        • Miyazaki Medical Association Hospital
      • Nagoya-shi, Japan, 466-8650
        • Recruiting
        • Japanese Red Cross Nagoya Daini Hospital
      • Narashino-shi, Japan, 275-8580
        • Recruiting
        • Saiseikai Narashino Hospital
      • Nishinomiya-shi, Japan, 663-8501
        • Recruiting
        • Hyogo Medical University Hospital
      • Nishitokyo-shi, Japan, 202-0012
        • Recruiting
        • Miwa Heart Clinic
      • Okayama-shi, Japan, 700-8558
        • Recruiting
        • Okayama University Hospital
      • Okinawa, Japan, 902-8511
        • Recruiting
        • Naha City Hospital
      • Osaka, Japan, 565-0871
        • Recruiting
        • Osaka University Hospital
      • Osaka, Japan, 543-0035
        • Recruiting
        • Osaka Police Hospital
      • Osaka Sayama shi, Japan, 589 8511
        • Recruiting
        • Kindai University Hospital
      • Osaka-shi, Japan, 540-0006
        • Recruiting
        • National Hospital Organization Osaka National Hospital
      • Osaka-shi, Japan, 530-0001
        • Recruiting
        • Sakurabashi Watanabe Hospital
      • Sagamihara, Japan, 252-0375
        • Recruiting
        • Kitasato University Hospital
      • Saitama-shi, Japan, 339-0033
        • Recruiting
        • Kosekai Iwatsuki-minami Hospital
      • Sapporo-shi, Japan, 003-0026
        • Recruiting
        • Matsuda Hospital
      • Sapporo-shi, Japan, 064-8570
        • Recruiting
        • Miyanomori Memorial Hospital
      • Sendai shi, Japan, 980 8574
        • Recruiting
        • Tohoku University Hospital
      • Shinagawa, Japan, 142-8666
        • Recruiting
        • Showa University Hospital
      • Shinjuku-ku, Japan, 162-8666
        • Recruiting
        • Tokyo Women's Medical University Hospital
      • Suita-Shi, Japan, 564-8565
        • Recruiting
        • National Cerebral and Cardiovascular Center
      • Takatsuki-shi, Japan, 569-1096
        • Recruiting
        • Takatsuki Red Cross Hospital
      • Tokyo, Japan, 173-8610
        • Recruiting
        • Nihon University Itabashi Hospital
      • Tokyo, Japan, 160-0023
        • Recruiting
        • Tokyo Medical University Hospital
      • Tokyo, Japan, 113-8603
        • Recruiting
        • Nippon Medical School Hospital
      • Tokyo, Japan, 192-0038
        • Recruiting
        • Kenshinkai Minamino Cardiovascular Hospital
      • Tokyo, Japan, 198-0042
        • Recruiting
        • Ome Medical Center
      • Tokyo, Japan, 106-0031
        • Recruiting
        • The Cardiovascular Institute
      • Tokyo, Japan, 181 8611
        • Recruiting
        • Kyorin University Hospital
      • Tomakomai, Japan, 053-8506
        • Recruiting
        • Oji General Hospital
      • Toyoake, Japan, 470-1192
        • Recruiting
        • Fujita Health University Hospital
      • Uwajima-shi, Japan, 798-8510
        • Recruiting
        • Uwajima City Hospital
      • Yokohama, Japan, 222-0036
        • Recruiting
        • Yokohama Rosai Hospital
      • Yokohama, Japan, 232 0024
        • Recruiting
        • Yokohama City University Medical Center
      • Yufu, Japan, 879-5593
        • Recruiting
        • Oita University Hospital
      • Busan, Korea, Republic of, 47392
        • Recruiting
        • Inje University Busan Paik Hospital
      • Busan, Korea, Republic of, 602 812
        • Recruiting
        • Dong-A University Hospital
      • Cheongju-si, Korea, Republic of, 28644
        • Recruiting
        • Chungbuk National University Hospital
      • Daegu, Korea, Republic of, 42601
        • Recruiting
        • Keimyung University Dongsan Hospital
      • Goyang-si, Korea, Republic of, 10380
        • Recruiting
        • Inje University Ilsan Paik Hospital
      • Gwangju, Korea, Republic of, 61469
        • Recruiting
        • Chonnam National University Hospital
      • Gyeonggi-do, Korea, Republic of, 13496
        • Recruiting
        • Cha Bundang Medical Center, Cha University
      • Seoul, Korea, Republic of, 06351
        • Recruiting
        • Samsung Medical Center
      • Seoul, Korea, Republic of, 120-752
        • Recruiting
        • Severance Hospital, Yonsei University Health System
      • Kaunas, Lithuania, 49387
        • Recruiting
        • Klinikiniai sprendimai JSC
      • Kaunas, Lithuania, 49449
        • Recruiting
        • Saules Seimos Medicinos Centras, JSC
      • Kaunas, Lithuania, LT-47144
        • Recruiting
        • Kaunas Clinical Hospital, Public Institution
      • Klaipeda, Lithuania, LT-92288
        • Recruiting
        • Klaipeda Seamen's Hospital, Public Institution
      • Vilnius, Lithuania, 08661
        • Recruiting
        • Vilnius University Hospital Santariskiu Clinic, Public Institution
      • Vilnius, Lithuania, LT-08406
        • Recruiting
        • Inlita, JSC
      • Vilnius, Lithuania, LT-08661
        • Recruiting
        • Vilnius University Hospital Santariskiu Clinic, Public Institution
      • Vilnius, Lithuania, LT-08406
        • Recruiting
        • Inmedica, JSC
      • Kota Kinabalu, Malaysia, 88300
        • Recruiting
        • Queen Elizabeth II Hospital
      • Kuala Lumpur, Malaysia, 50400
        • Recruiting
        • Institut Jantung Negara
      • Seri Manjung, Malaysia, 32040
        • Recruiting
        • Hospital Seri Manjung
      • Taiping, Malaysia, 34000
        • Recruiting
        • Hospital Taiping
      • Alkmaar, Netherlands, 1815 JD
        • Recruiting
        • Noordwest Ziekenhuisgroep
      • Almelo, Netherlands, 7609
        • Recruiting
        • ZGT Cardioresearch
      • Amersfoort, Netherlands, 3813 TZ
        • Recruiting
        • Meander Medisch Centrum
      • Amsterdam, Netherlands, 1091 AC
        • Recruiting
        • Onze Lieve Vrouwe Gasthuis
      • Delft, Netherlands, 2625 AD
        • Recruiting
        • Reinier de Graaf Gasthuis
      • Deventer, Netherlands, 7416 SE
        • Recruiting
        • Deventer Ziekenhuis
      • Doetinchem, Netherlands
        • Recruiting
        • Slingeland Ziekenhuis
      • Ede, Netherlands, 6716 RP
        • Recruiting
        • Ziekenhuis Gelderse Vallei
      • Eindhoven, Netherlands, 5623 EJ
        • Recruiting
        • Catharina Ziekenhuis
      • Gouda, Netherlands, 2800 BB
        • Recruiting
        • Groene Hart Ziekenhuis
      • Heerlen, Netherlands, 6419 PC
        • Recruiting
        • Atrium Med.Centrum Heerlen - Afd.Interne - INT
      • Helmond, Netherlands, 5707 HA
        • Recruiting
        • Elkerliek Ziekenhuis
      • Leiderdorp, Netherlands, 2353 GA
        • Recruiting
        • Alrijne Ziekenhuis Leiden ; Cardiology
      • Nieuwegein, Netherlands, 3435 CM
        • Recruiting
        • St. Antonius Ziekenhuis Nieuwegein
      • Nijmegen, Netherlands, 6525GA
        • Recruiting
        • Radboudumc
      • Rotterdam, Netherlands, 3045 PM
        • Recruiting
        • Sint Franciscus Gasthuis
      • Rotterdam, Netherlands, 3083 AN
        • Recruiting
        • Ikazia Ziekenhuis
      • Sneek, Netherlands, 8601 ZR
        • Recruiting
        • D & A Research
      • Tilburg, Netherlands, 5022 GC
        • Recruiting
        • ETZ Elisabeth
      • Veldhoven, Netherlands, 5504 DB
        • Recruiting
        • Maxima Medisch Centrum
      • Zutphen, Netherlands, 7207 AE
        • Recruiting
        • Gelre Ziekenhuizen Zutphen
      • s-Hertogenbosch, Netherlands, 5223 GZ
        • Recruiting
        • Jeroen Bosch Ziekenhuis
      • Auckland, New Zealand, 1030
        • Recruiting
        • Auckland City Hospital
      • Auckland, New Zealand, 0740
        • Recruiting
        • North Shore Hospital
      • Christchurch, New Zealand, 8140
        • Recruiting
        • University of Otago
      • Dunedin, New Zealand, 9016
        • Recruiting
        • Dunedin Public Hospital
      • Hamilton, New Zealand, 3200
        • Recruiting
        • Waikato Hospital
      • Hastings, New Zealand
        • Recruiting
        • Hawkes Bay Hospital
      • Rotorua, New Zealand, 3010
        • Recruiting
        • Rotorua Hospital
      • Tauranga, New Zealand, 3143
        • Recruiting
        • Tauranga Hospital
      • Bydgoszcz, Poland, 85-048
        • Recruiting
        • IN VIVO Sp. z o.o
      • Bydgoszcz, Poland, 85-796
        • Recruiting
        • Centrum Medyczne Pratia Bydgoszcz
      • Bydgoszcz, Poland, 85-231
        • Recruiting
        • NZOZ Centrum Medyczne KERmed
      • Chojnice, Poland, 89-600
        • Recruiting
        • Centrum Medyczne Pratia Chojnice
      • Chorzow, Poland, 41-500
        • Recruiting
        • M2M Badania Kliniczne
      • Chrzanow, Poland, 32-500
        • Recruiting
        • Centrum Medyczne MBB-MED
      • Gdansk, Poland, 80-286
        • Recruiting
        • Poradnia Kardiologiczna Jaroslaw Jurowiecki
      • Gdynia, Poland, 81-157
        • Recruiting
        • Private Practice - Dr. Krzysztof Cymerman
      • Gdynia, Poland, 81-423
        • Recruiting
        • NZOZ Procordis Pawel Miekus
      • Grodzisk Mazowiecki, Poland, 05-825
        • Recruiting
        • MCBK Iwona Czajkowska Anna Podrażka- Szczepaniak S.C.
      • Jelenia Góra, Poland, 58-506
        • Recruiting
        • Centrum Medyczne Pratia Jelenia Gora
      • Katowice, Poland, 40-156
        • Recruiting
        • Clinical Medical Research Sp. z o.o.
      • Katowice, Poland, 40-282
        • Recruiting
        • Silmedic sp. z o.o
      • Katowice, Poland, 40-555
        • Recruiting
        • Kardio Klinika Brynow
      • Krakow, Poland, 31-216
        • Recruiting
        • Centrum Medyczne Zdrowa J. Trębacz W. Zajdel s.j.
      • Krakow, Poland, 30-721
        • Recruiting
        • Centrum Medyczne Linden
      • Krakow, Poland, 30-082
        • Recruiting
        • Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska
      • Krakow, Poland, 31-501
        • Recruiting
        • Krakowskie Centrum Medyczne Sp z o o NZOZ
      • Krakow, Poland, 31-826
        • Recruiting
        • Oddzial Ortopedii i Traumatologii Narzadu Ruchu Szpital Specjalistyczny im. Ludwika Rydygiera
      • Legnica, Poland, 59-220
        • Recruiting
        • B.Miklaszewicz&D.Dabrowski CARDIMED Spolka Jawna
      • Lodz, Poland, 90-302
        • Recruiting
        • Santa Familia Centrum Badan, Profilaktyki i Leczenia
      • Lodz, Poland, 91-363
        • Recruiting
        • Centrum Medyczne AMED Oddzial w Lodzi
      • Lodz, Poland, 94-255
        • Recruiting
        • Indywidualna Specjalistyczna Praktyka Lekarska
      • Lodz, Poland, 94-048
        • Recruiting
        • NZOZ ALL-MED Centrum Medyczne Specjalistyczne Gabinety Lekarskie
      • Lowicz, Poland, 99-400
        • Recruiting
        • Lowickie Centrum Kardiologii
      • Lublin, Poland, 20-412
        • Recruiting
        • ETG Lublin
      • Lublin, Poland, 20-362
        • Recruiting
        • KO-MED Centra Kliniczne LUBLIN
      • Olsztyn, Poland, 10-010
        • Recruiting
        • FutureMeds Olsztyn
      • Ostrowiec Swietokrzyski, Poland, 27-400
        • Recruiting
        • Ostrowieckie Centrum Medyczne Spolka Cywilna Anna Olech-Cudzik, Krzysztof Cudzik
      • Oswiecim, Poland, 32-600
        • Recruiting
        • Medicome Sp. z o.o.
      • Piaseczno, Poland, 05-500
        • Recruiting
        • NZOZ Heureka
      • Poznan, Poland, 61-853
        • Recruiting
        • NZOZ NEURO-KARD Ilkowski i Partnerzy Sp. Partnerska Lekarzy
      • Rzeszow, Poland, 35-055
        • Recruiting
        • Centrum Medyczne MEDYK
      • Siedlce, Poland, 08-110
        • Recruiting
        • ETG Siedlce
      • Skierniewice, Poland, 96-100
        • Recruiting
        • Centrum Medyczne Ogrodowa sp. z o.o.
      • Warsaw, Poland, 03 291
        • Recruiting
        • FutureMeds Targowek
      • Warsaw, Poland, 00 2015
        • Recruiting
        • FutureMeds Warszawa Centrum
      • Warszawa, Poland, 02-793
        • Recruiting
        • ETG Warszawa
      • Zamosc, Poland, 22-400
        • Recruiting
        • ETG Zamosc
      • Zamosc, Poland, 22-400
        • Recruiting
        • KO-MED Centra Kliniczne Zamosc
      • Covilha, Portugal, 6200-074
        • Recruiting
        • Centro Hospitalar Cova da Beira, EPE - Hospital Pêro da Covilhã
      • Figueira da Foz, Portugal, 3094-001
        • Recruiting
        • Hospital Distrital Fig Da Foz Gala
      • Lisboa, Portugal, 1649-035
        • Recruiting
        • Centro Hospitalar de Lisboa Norte Hospital Santa Maria
      • Lisboa, Portugal, 2790-134
        • Recruiting
        • Centro Hospitalar Lisboa Ocidental - Hospital São Fracisco Xavier
      • Santa Maria da Feira, Portugal, 4520-211
        • Recruiting
        • Centro Hospitalar de Entre o Douro e Vouga, E.P.E
      • Torres Novas, Portugal, 2350-325
        • Recruiting
        • Largo da Igreja Velha Edifício CCA
      • Vila Nova de Gaia, Portugal, 4434-502
        • Recruiting
        • Centro Hospitalar de Vila Nova de Gaia Espinho E P E
      • Braila, Romania, 810119
        • Recruiting
        • Spitalul Județean de Urgență Brăila
      • Brasov, Romania, 500091
        • Recruiting
        • Centrul Medical Unirea SRL
      • Brasov, Romania, 500283
        • Recruiting
        • Centrul Medical de Diagnostic si Tratament Ambulator NEOMED
      • Bucharest, Romania, 022322
        • Recruiting
        • Institutul de urgenta pentru Boli Cardiovasculare Prof. Dr. C.C. Iliescu
      • Bucuresti, Romania, 010192
        • Recruiting
        • Clinica Medicala Data Plus SRL
      • Bucuresti, Romania, 014142
        • Recruiting
        • S C Delta Health Care S R L
      • Cluj-Napoca, Romania, 400000
        • Recruiting
        • Spitalul Angiocare SRL
      • Iasi, Romania, 700503
        • Recruiting
        • Institutul de Boli Cardiovasculare Iasi
      • Iasi, Romania, 700786
        • Recruiting
        • Cardiomed SRL
      • Pitesti, Romania, 110424
        • Recruiting
        • SAL MED Pitesti
      • Sibiu, Romania, 550245
        • Recruiting
        • Spitalul Clinic Judetean Sibiu
      • Suceava, Romania, 720049
        • Recruiting
        • Cabinet Medical Cardiologie Cojocariu Titel Razvan
      • Targu Mures, Romania, 540143
        • Recruiting
        • Cmi Dr Podoleanu Cristian
      • Belgrade, Serbia, 11000
        • Recruiting
        • University Clinical Center of Serbia
      • Belgrade, Serbia, 11080
        • Recruiting
        • University Clinical Hospital Center Dr Dragisa Misovic- Dedi
      • Pancevo, Serbia, 26000
        • Recruiting
        • General Hospital Pancevo
      • Smederevo, Serbia, 11300
        • Recruiting
        • General Hospital Smederevo
      • Sremska Mitrovica, Serbia, 22000
        • Recruiting
        • General Hospital Sremska Mitrovica
      • Bardejov, Slovakia, 08501
        • Recruiting
        • ALIAN s.r.o.
      • Bardejov, Slovakia, 08501
        • Recruiting
        • Thyreomedical s r o
      • Bratislava, Slovakia, 85101
        • Recruiting
        • Veria, s.r.o Kardiologicka ambulancia
      • Bratislava, Slovakia, 83101
        • Recruiting
        • Kardiovaskularne centrum, s.r.o.
      • Bratislava, Slovakia, 83348
        • Recruiting
        • Narodny ustav srdcovych a cievnych chorob
      • Kosice, Slovakia, 4001
        • Recruiting
        • Kardiologicka ambulancia Medicalgroup s.r.o.
      • Kosice, Slovakia, 04022
        • Recruiting
        • CARDIO D&R, s.r.o.
      • Košice, Slovakia, 040 11
        • Recruiting
        • Vychodoslovensky ustav srdcovych a cievnych chorob, a.s.
      • Lucenec, Slovakia, 98401
        • Recruiting
        • Kardio 1 S.R.O.
      • Lucenec, Slovakia, 98401
        • Recruiting
        • Kardiomed, S.R.O.
      • Moldava nad Bodvou, Slovakia, 4501
        • Recruiting
        • Kardiologicka ambulancia MEDI M&M s.r.o.
      • Nove Zamky, Slovakia, 94052
        • Recruiting
        • Cardioinvest s.r.o.
      • Presov, Slovakia, 08001
        • Recruiting
        • Medispol s.r.o Interna a kardiologicka ambulancia
      • Svidnik, Slovakia, 08901
        • Recruiting
        • Interna SK s.r.o.
      • Zilina, Slovakia, 01001
        • Recruiting
        • Medivasa s.r.o.
      • Cape Town, South Africa, 7500
        • Recruiting
        • TREAD Research
      • Centurion, South Africa, 0157
        • Recruiting
        • Johese Clinical Research
      • Johannesburg, South Africa, 2192
        • Recruiting
        • Garda, RA
      • Krugersdorp, South Africa, 1739
        • Recruiting
        • DJW Research
      • Pretoria, South Africa, 0002
        • Recruiting
        • Clinical Research Unit, University of Pretoria
      • Pretoria, South Africa, 0181
        • Recruiting
        • Into Research
      • Somerset West, South Africa, 7130
        • Recruiting
        • Dr J.M. Engelbrecht Trial Site
      • Somerset West, South Africa, 7130
        • Recruiting
        • Helderberg Research Institute
      • Tongaat, South Africa, 4399
        • Recruiting
        • Mediclinic Victoria Hospital
      • Worcester, South Africa, 6850
        • Recruiting
        • Clinical Projects Research SA (PTY) LTD
      • A Coruña, Spain, 15006
        • Recruiting
        • Hosp. Univ. A Coruna
      • Alicante, Spain, 3540
        • Recruiting
        • Hosp. Gral. Univ. de Alicante
      • Barcelona, Spain, 08003
        • Recruiting
        • Hosp. Del Mar
      • Barcelona, Spain, 08041
        • Recruiting
        • Hosp. de La Santa Creu I Sant Pau
      • El Palmar, Spain, 30120
        • Recruiting
        • Hosp. Univ. Virgen de La Arrixaca
      • Lleida, Spain, 25198
        • Recruiting
        • Hosp. Univ. Arnau de Vilanova de Lleida
      • Madrid, Spain, 28046
        • Recruiting
        • Hosp. Univ. La Paz
      • Malaga, Spain, 29010
        • Recruiting
        • Hosp. Virgen de La Victoria
      • Santiago de Compostela, Spain, 15706
        • Recruiting
        • Hosp. Clinico Univ. de Santiago
      • Valencia, Spain, 46010
        • Recruiting
        • Hosp. Clinico Univ. de Valencia
      • Valencia, Spain, 46014
        • Recruiting
        • Hosp. Clinico Univ. de Valencia
      • Changhua, Taiwan, 50006
        • Recruiting
        • Changhua Christian Hospital
      • Kaohsiung, Taiwan, 80756
        • Recruiting
        • Kaohsiung Medical University Chung-Ho Memorial Hospital
      • Kaohsiung, Taiwan, 82445
        • Recruiting
        • E-DA Hospital
      • New Taipei, Taiwan, 22060
        • Recruiting
        • Far Eastern Memorial Hospital
      • New Taipei, Taiwan, 25160
        • Recruiting
        • Mackay Memorial Hospital
      • Taichung, Taiwan, 40447
        • Recruiting
        • China Medical University Hospital
      • Taipei, Taiwan, 10002
        • Recruiting
        • National Taiwan University Hospital
      • Taipei, Taiwan, 11490
        • Recruiting
        • Tri-Service General Hospital
      • Taipei, Taiwan, 106
        • Recruiting
        • Cathay General Hospital
      • Taipei, Taiwan, 116
        • Recruiting
        • Taipei Municipal Wanfang Hospital
      • Taipei City, Taiwan, 112201
        • Recruiting
        • Taipei Veterans General Hospital
      • Taoyuan County, Taiwan, 33305
        • Recruiting
        • Chang Gung Memorial Hospital- Linkou
      • Bristol, United Kingdom, BS1 3NU
        • Recruiting
        • Bristol Royal Infirmary
      • Lincoln, United Kingdom, LN2 5QY
        • Recruiting
        • Lincoln County Hospital
      • London, United Kingdom, EC1A 7BE
        • Recruiting
        • Barts Hospital
      • Sheffield, United Kingdom, S5 7AU
        • Recruiting
        • Northern General Hospital
      • Truro, United Kingdom, TR1 3LJ
        • Recruiting
        • Royal Cornwall Hospital
      • Wigan, United Kingdom, WN1 2NN
        • Recruiting
        • Wrightington Hospital,Wrightington, Wigan and Leigh NHS Trus
    • Alabama
      • Alexander City, Alabama, United States, 35010
        • Recruiting
        • Advanced Cardiovascular, LLC
      • Birmingham, Alabama, United States, 35205
        • Recruiting
        • Ascension St. Vincent's Health System
      • Dothan, Alabama, United States, 36303
        • Recruiting
        • SEC Clinical Research
      • Huntsville, Alabama, United States, 35801
        • Recruiting
        • HH Heart Center and Heart Center
      • Mobile, Alabama, United States, 36608
        • Recruiting
        • CB Flock Research Corporation
    • Arizona
      • Gilbert, Arizona, United States, 85297
        • Recruiting
        • Mercy Gilbert Medical Center
      • Phoenix, Arizona, United States, 85008
        • Recruiting
        • Valleywise Health Medical Center
      • Phoenix, Arizona, United States, 85016
        • Recruiting
        • Arizona Heart Hospital
      • Phoenix, Arizona, United States, 85016
        • Recruiting
        • Arizona Arrhythmia Research Center
      • Scottsdale, Arizona, United States, 85251
        • Recruiting
        • HonorHealth Neurology
    • Arkansas
      • Little Rock, Arkansas, United States, 72211
        • Recruiting
        • Arkansas Heart Hospital
    • California
      • Bakersfield, California, United States, 93301
        • Recruiting
        • Bakersfield Memorial Hospital
      • Beverly Hills, California, United States, 90211
        • Recruiting
        • Vitality Clinical Research
      • Chula Vista, California, United States, 91911
        • Recruiting
        • Sharp Chula Vista Medical Center
      • Chula Vista, California, United States, 91910
        • Recruiting
        • Chula Vista Cardiac Clinic
      • Fremont, California, United States, 94538
        • Suspended
        • Mission Cardiovascular Research Institute
      • Glendora, California, United States, 91741
        • Completed
        • Paradise Clinical Research Group LLC
      • Long Beach, California, United States, 90806
        • Recruiting
        • Miller Children's at Long Beach Medical Center
      • Los Angeles, California, United States, 90017
        • Suspended
        • Los Angeles Cardiology Associates
      • Merced, California, United States, 95340
        • Recruiting
        • Merced Vein and Vascular Center
      • Newport Beach, California, United States, 92663
        • Recruiting
        • Radin Cardiovascular Medical Group
      • Northridge, California, United States, 91325
        • Recruiting
        • Valley Clinical Trials, Inc.
      • Northridge, California, United States, 91324
        • Recruiting
        • California Medical Research Associates, Inc.
      • Palm Springs, California, United States, 92262
        • Recruiting
        • Desert Oasis Health Care
      • Pasadena, California, United States, 91105
        • Completed
        • Havana Research Institute LLC
      • Rancho Mirage, California, United States, 92270
        • Recruiting
        • Eisenhower Desert Cardiology Center
      • San Diego, California, United States, 92123
        • Recruiting
        • San Diego Cardiac Center
      • Santa Ana, California, United States, 92705
        • Recruiting
        • Syrentis Clinical Research
      • Stockton, California, United States, 95204
        • Recruiting
        • Ramin Manshadi, MD
      • Torrance, California, United States, 90502
        • Recruiting
        • UCLA School of Medicine
      • Ventura, California, United States, 93003
        • Recruiting
        • Cardiology Associates Medical Group
      • Vista, California, United States, 92083
        • Recruiting
        • North County Internal Medicine
      • Walnut Creek, California, United States, 94598
        • Recruiting
        • John Muir Physician Network Clin. Research Center
    • Colorado
      • Aurora, Colorado, United States, 80012
        • Recruiting
        • Aurora Denver Cardiology Associates
      • Denver, Colorado, United States, 80218
        • Recruiting
        • Aurora Denver Cardiology Associates
      • Wheat Ridge, Colorado, United States, 80033
        • Recruiting
        • Paradigm Clinical Research Centers, Inc.
    • Connecticut
      • Bridgeport, Connecticut, United States, 06610
        • Recruiting
        • Bridgeport Hospital
      • Danbury, Connecticut, United States, 06810
        • Recruiting
        • Western Connecticut Health Network/Danbury Hospital
      • Stamford, Connecticut, United States, 06905
        • Recruiting
        • Cardiology Associates of Fairfield County
      • Trumbull, Connecticut, United States, 06611
        • Recruiting
        • PriMed Physicians, A Member of NE Medical Group
    • Delaware
      • Newark, Delaware, United States, 19713
        • Recruiting
        • Cardiology Physicians
    • Florida
      • Altamonte Springs, Florida, United States, 32714
        • Suspended
        • Orlando Heart Specialists
      • Brandon, Florida, United States, 33511
        • Recruiting
        • Bay Area Cardiology Associates, P.A. - Brandon Office
      • Clearwater, Florida, United States, 33756
        • Recruiting
        • Clearwater Cardiovascular Consultants
      • Daytona Beach, Florida, United States, 32117
        • Recruiting
        • Cardiology Associates Research Company
      • Daytona Beach, Florida, United States, 32114
        • Recruiting
        • Cardiology Consultants
      • DeLand, Florida, United States, 32720
        • Recruiting
        • Accel Research Sites
      • Gainesville, Florida, United States, 32605
        • Recruiting
        • The Cardiac & Vascular Institute Research Foundation
      • Jacksonville, Florida, United States, 32216
        • Recruiting
        • East Coast Institute for Research
      • Lakeland, Florida, United States, 33805
        • Recruiting
        • Watson Clinic
      • Largo, Florida, United States, 33777
        • Recruiting
        • Clearwater Cardiovascular Consultants
      • Miami, Florida, United States, 33155
        • Recruiting
        • Miami Clinical Research
      • Miami, Florida, United States, 33173
        • Recruiting
        • Suncoast Research Associates, LLC
      • Miami, Florida, United States, 33165
        • Recruiting
        • Reliant Medical Research
      • Miramar Beach, Florida, United States, 32550
        • Recruiting
        • Ascension Sacred Heart Hospital
      • New Port Richey, Florida, United States, 34652
        • Recruiting
        • Suncoast Clinical Research
      • Orange City, Florida, United States, 32763-9116
        • Recruiting
        • Central Florida Medical Associates
      • Palm Beach Gardens, Florida, United States, 33410
        • Recruiting
        • Cardiology Partners Clinical Research Institute
      • Pensacola, Florida, United States, 32501
        • Recruiting
        • Cardiology Consultants
      • Pompano Beach, Florida, United States, 33064
        • Recruiting
        • North Broward Hospital District
      • Port Charlotte, Florida, United States, 33952
        • Recruiting
        • Charlotte Heart Group Research Center
      • Safety Harbor, Florida, United States, 34695
        • Recruiting
        • Coastal Cardiology Consultants
      • Saint Petersburg, Florida, United States, 33705
        • Recruiting
        • Heart and Vascular Institute of Florida
      • Sarasota, Florida, United States, 34239-3513
        • Recruiting
        • Cardiovascular Center of Sarasota
      • Tampa, Florida, United States, 33613
        • Recruiting
        • Florida Hospital Tampa
      • Tampa, Florida, United States, 33634
        • Recruiting
        • Helping Hands Health Center dba Helping Hands Evolution Research
      • Tampa, Florida, United States, 33607
        • Recruiting
        • Adtremed Inc
      • Wellington, Florida, United States, 33449
        • Recruiting
        • Cardiology Partners Clinical Research Institute
    • Georgia
      • Atlanta, Georgia, United States, 30303
        • Suspended
        • Grady Memorial Hospital
      • Columbus, Georgia, United States, 31904
        • Recruiting
        • Columbus Regional Research Institute
      • Cumming, Georgia, United States, 30041
        • Recruiting
        • Atlanta Heart Specialists
      • Gainesville, Georgia, United States, 30501
        • Recruiting
        • Northeast Georgia Heart Center
      • Thomasville, Georgia, United States, 31792
        • Recruiting
        • Cardiology Consultants of South Georgia Inc
    • Idaho
      • Coeur d'Alene, Idaho, United States, 83814
        • Recruiting
        • Kootenai Medical Center
    • Illinois
      • Gurnee, Illinois, United States, 60031
        • Recruiting
        • Clinical Investigation Specialists
      • Hazel Crest, Illinois, United States, 60429
        • Recruiting
        • Chicago Medical Research, LLC
      • Naperville, Illinois, United States, 60540
        • Recruiting
        • Midwest Cardiovascular Institute
      • O'Fallon, Illinois, United States, 62269
        • Recruiting
        • Prairie Education And Research Cooperative
      • Peoria, Illinois, United States, 61636
        • Recruiting
        • Methodist Medical Center of Illinois
      • Rockford, Illinois, United States, 61107-5059
        • Recruiting
        • OSF HealthCare Cardiovascular Institute
      • Springfield, Illinois, United States, 62702
        • Recruiting
        • Springfield Clinic 1st
    • Indiana
      • Bloomington, Indiana, United States, 47402
        • Recruiting
        • Bloomington Hospital
      • Indianapolis, Indiana, United States, 46260
        • Recruiting
        • St. Vincent Medical Group, Inc.
      • Muncie, Indiana, United States, 47303
        • Recruiting
        • IU Health Ball Memorial Hospital
    • Kentucky
      • Crittenden, Kentucky, United States, 41030
        • Recruiting
        • St. Elizabeth Physicians
      • Louisville, Kentucky, United States, 40202
        • Recruiting
        • Kentuckyone Health Neurology Associates
      • Owensboro, Kentucky, United States, 42303
        • Recruiting
        • Owensboro Medical Practice
    • Louisiana
      • Alexandria, Louisiana, United States, 71301
        • Recruiting
        • Cambridge Medical Trials
      • Bossier City, Louisiana, United States, 71111
        • Recruiting
        • Grace Research, LLC - Bossier City
      • Chalmette, Louisiana, United States, 70043
        • Recruiting
        • Medical Research Specialists
      • Houma, Louisiana, United States, 70360
        • Recruiting
        • Cardiovascular Institute of the South
      • Shreveport, Louisiana, United States, 71115
        • Recruiting
        • Pierremont Cardiology
      • Shreveport, Louisiana, United States, 71103
        • Suspended
        • Louisiana State University Health Sciences Center
      • West Monroe, Louisiana, United States, 71291
        • Recruiting
        • Clinical Trials of America
    • Maryland
      • Annapolis, Maryland, United States, 21401
        • Recruiting
        • Luminis Health Anne Arundel Medical Center
      • Bethesda, Maryland, United States, 20814
        • Recruiting
        • Suburban Hospital
      • Columbia, Maryland, United States, 21044
        • Recruiting
        • Johns Hopkins University
      • Rockville, Maryland, United States, 20850
        • Recruiting
        • Shady Grove Office
      • Salisbury, Maryland, United States, 21804
        • Recruiting
        • Tidal Health Peninsula Regional Inc.
      • Towson, Maryland, United States, 21204
        • Recruiting
        • Spectrum Clinical Research, Inc.
    • Michigan
      • Flint, Michigan, United States, 48503
        • Recruiting
        • Flint Clinical Research
      • Lansing, Michigan, United States, 48912
        • Recruiting
        • Sparrow Clinical Research Institute
      • Petoskey, Michigan, United States, 49770
        • Recruiting
        • Michigan Heart & Vascular Institute
      • Southgate, Michigan, United States, 48195
        • Suspended
        • Revival Research Institute, LLC
      • Troy, Michigan, United States, 48085
        • Recruiting
        • Oakland Medical Research
    • Minnesota
      • Bloomington, Minnesota, United States, 55426
        • Recruiting
        • HealthPartners Institute
    • Mississippi
      • Olive Branch, Mississippi, United States, 38654
        • Recruiting
        • Olive Branch Family Medical Center
    • Missouri
      • Columbia, Missouri, United States, 65211
        • Recruiting
        • The Curators of the University of Missouri on behalf of University of Missouri Health Care
      • Saint Louis, Missouri, United States, 63136
        • Recruiting
        • St. Louis Heart and Vascular
    • New Jersey
      • Bridgewater, New Jersey, United States, 08807
        • Recruiting
        • Advanced Heart Care, LLC
      • Marlton, New Jersey, United States, 08053
        • Recruiting
        • Virtua Medical Group, PA
    • New York
      • Bronx, New York, United States, 10469
        • Recruiting
        • Cardiac Care & Vascular Medicine, PLLC
      • Jamaica, New York, United States, 11418
        • Recruiting
        • Jamaica Hospital Medical Center
      • Kingston, New York, United States, 12401
        • Recruiting
        • Westchester Medical Center Advanced Physician Services PC
      • Laurelton, New York, United States, 11413
        • Recruiting
        • Laurelton Heart Specialist, PC
      • Middletown, New York, United States, 10941
        • Recruiting
        • Crystal Run Healthcare LLP
      • Mineola, New York, United States, 11501
        • Recruiting
        • NYU Langone Hospital Long Island
      • New York, New York, United States, 10075
        • Recruiting
        • Lenox Hill Hospital
      • New York, New York, United States, 10021
        • Recruiting
        • Weill Cornell Medical College
    • North Carolina
      • Greensboro, North Carolina, United States, 27405
        • Recruiting
        • Guilford Neurologic Associates
      • Lenoir, North Carolina, United States, 28645
        • Recruiting
        • Clinical Trials of America
      • Pinehurst, North Carolina, United States, 28374
        • Recruiting
        • Pinehurst Medical Clinic Inc
      • Sanford, North Carolina, United States, 27330
        • Recruiting
        • Sanford Cardiology
      • Wilmington, North Carolina, United States, 28401
        • Recruiting
        • Wilmington Health Associates
    • North Dakota
      • Minot, North Dakota, United States, 58701
        • Recruiting
        • Trinity Medical Group
    • Ohio
      • Akron, Ohio, United States, 44304
        • Recruiting
        • Summa Health System
      • Cincinnati, Ohio, United States, 45219
        • Recruiting
        • The Lindner Clinical Trial Center
      • Dayton, Ohio, United States, 45414
        • Recruiting
        • Dayton Heart Center
      • Maumee, Ohio, United States, 43537
        • Recruiting
        • Advanced Medical Research
      • Springfield, Ohio, United States, 45505
        • Recruiting
        • The Heart House
      • Zanesville, Ohio, United States, 43701
        • Recruiting
        • Genesis Healthcare System
    • Oklahoma
      • Bartlesville, Oklahoma, United States, 74006
        • Recruiting
        • Ascension Medical Group - St. John Clinic Infectious Disease
      • Oklahoma City, Oklahoma, United States, 73135
        • Recruiting
        • South Oklahoma Heart Research
      • Oklahoma City, Oklahoma, United States, 73120
        • Suspended
        • Oklahoma Heart Hospital
      • Tulsa, Oklahoma, United States, 74104
        • Recruiting
        • St John Health System Inc
    • Pennsylvania
      • Newport, Pennsylvania, United States, 17074
        • Recruiting
        • Capital Area Research
      • Philadelphia, Pennsylvania, United States, 19104
        • Recruiting
        • Penn Presbyterian Medical Center
      • Pittsburgh, Pennsylvania, United States, 15240
        • Recruiting
        • VA Pittsburgh Healthcare System
      • Pittsburgh, Pennsylvania, United States, 15213
        • Recruiting
        • Hudson Valley Cardiovascular Practice, PC
      • Sayre, Pennsylvania, United States, 18840
        • Recruiting
        • Donald Guthrie Foundation
      • Yardley, Pennsylvania, United States, 19067
        • Recruiting
        • Cardiology Consultants of Philadelphia
      • York, Pennsylvania, United States, 17403-3676
        • Recruiting
        • York Hospital
    • South Carolina
      • Anderson, South Carolina, United States, 29621
        • Recruiting
        • AnMed Health
      • Anderson, South Carolina, United States, 29621
        • Recruiting
        • Internal Medicine Associates of Anderson
      • Columbia, South Carolina, United States, 29204
        • Recruiting
        • MUSC Health Heart Vascular Columbia Medical Park DT III
      • Greenville, South Carolina, United States, 29607
        • Recruiting
        • St. Francis Physician Services, Inc, DBA Upstate Cardiology Research
    • South Dakota
      • Rapid City, South Dakota, United States, 57701
        • Recruiting
        • Black Hills Cardiovascular Research
    • Tennessee
      • Jackson, Tennessee, United States, 38301
        • Recruiting
        • Jackson Madison County General Hospital
      • Jackson, Tennessee, United States, 38301
        • Recruiting
        • Jackson Clinic
      • Kingsport, Tennessee, United States, 37660
        • Recruiting
        • Holston Medical Group
      • Knoxville, Tennessee, United States, 37923-4310
        • Recruiting
        • East Tennessee Heart Consultants
      • Nashville, Tennessee, United States, 37205
        • Recruiting
        • Saint Thomas Health
      • Powell, Tennessee, United States, 37849
        • Recruiting
        • Cardiovascular Associates
    • Texas
      • Amarillo, Texas, United States, 79109
        • Recruiting
        • PharmaTex Research
      • Amarillo, Texas, United States, 79124
        • Recruiting
        • Amarillo Heart Clinical Research Institute
      • Austin, Texas, United States, 78705
        • Recruiting
        • Ascension Texas Cardiovascular
      • Dallas, Texas, United States, 75231
        • Recruiting
        • Texas Health Dallas
      • Fort Worth, Texas, United States, 76104
        • Recruiting
        • Plaza Medical Center of Fort Worth
      • Houston, Texas, United States, 77002
        • Recruiting
        • East Texas Cardiology, PA
      • Houston, Texas, United States, 77024
        • Recruiting
        • PrimeCare Medical Group
      • Houston, Texas, United States, 77077
        • Recruiting
        • Novel Research LLC
      • Katy, Texas, United States, 77493
        • Recruiting
        • West Houston Area Clinical Trial Consultants LLC
      • Kingwood, Texas, United States, 77339
        • Recruiting
        • Texas Cardiology Research Center
      • Odessa, Texas, United States, 79761
        • Recruiting
        • Odessa Heart Institute
      • San Antonio, Texas, United States, 78215
        • Recruiting
        • Sun Research Institute
      • Sugar Land, Texas, United States, 77479
        • Recruiting
        • Southwest Medical Clinic
      • Tomball, Texas, United States, 77375
        • Recruiting
        • Northwest Houston Clinical Research
      • Waco, Texas, United States, 76712
        • Recruiting
        • Baylor Scott & White Research Institute
    • Utah
      • Farmington, Utah, United States, 84025
        • Recruiting
        • Alpine Research Organization
    • Virginia
      • Burke, Virginia, United States, 22015
        • Recruiting
        • Burke Internal Medicine and Research
      • Roanoke, Virginia, United States, 24014
        • Recruiting
        • Roanoke Heart Institute PLC
    • Washington
      • Tacoma, Washington, United States, 98405
        • Recruiting
        • Universal Research Group, LLC
    • Wisconsin
      • Wausau, Wisconsin, United States, 54401
        • Recruiting
        • Wausau Hospital
      • Wauwatosa, Wisconsin, United States, 53226
        • Recruiting
        • Allegiance Reserach Specialists, LLC

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Minimum age of 18 years
  • Medically stable and appropriate for chronic antithrombotic treatment
  • Atrial fibrillation eligible to receive anticoagulation
  • Participant must satisfy one or both of the following categories of risk factors (a or b): a) one or more of the following risk factors: i) age greater than or equal to 75 years, ii) history of any type of stroke including symptomatic stroke of any kind. b) two or more of the following risk factors: i) age between 65 and 74 years, ii) hypertension, iii) diabetes mellitus, iv) atherosclerotic vascular disease, v) heart failure

Exclusion Criteria:

  • Hemodynamically significant valve disease or those with valve disease that will potentially require surgical valve replacement during the study
  • Any condition other than AF that requires chronic anticoagulation

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Milvexian
Participants will receive milvexian 100 milligrams (mg) orally, twice daily and placebo that matches apixaban beginning on Day 1 through end of treatment (EOT). Participants after the EOT visit may have an option to receive open-label apixaban at the appropriate dose (5 mg or 2.5 mg, twice daily), for which the sponsor provides a 30-day supply.
Milvexian will be administered orally.
Milvexian matching milvexian placebo will be administered orally.
Active Comparator: Apixaban
Participants will receive a placebo that matches milvexian and a capsule containing apixaban 5 mg or 2.5 mg orally, twice daily. Participants after the EOT visit may have an option to receive open-label apixaban (5 mg or 2.5 mg, twice daily) at the appropriate dose, for which the sponsor provides a 30-day supply.
Apixaban will be administered orally.
Apixaban matching apixaban placebo will be administered orally.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Time to the First Occurrence of Composite Endpoint of Stroke and Non-central nervous system (CNS) Systemic Embolism
Time Frame: Up to 4 years
Time to the first occurrence of composite endpoint of stroke and non-CNS systemic embolism will be reported.
Up to 4 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Time to the First Occurrence of International Society of Thrombosis and Hemostasis (ISTH) Major Bleeding
Time Frame: Up to 4 years
Time to the first occurrence of ISTH major bleeding will be reported.
Up to 4 years
Time to the First Occurrence of the Composite of ISTH Major and Clinically Relevant Non-major (CRNM) Bleeding
Time Frame: Up to 4 years
Time to the first occurrence of the composite of ISTH major and CRNM bleeding will be reported.
Up to 4 years
Time to the First Occurrence of Composite Endpoint of Cardiovascular (CV) Death, Myocardial Infarction (MI), Stroke, and Non-CNS Systemic Embolism
Time Frame: Up to 4 years
Time to the first occurrence of composite endpoint of CV death, MI, stroke, and non-CNS systemic embolism will be reported.
Up to 4 years
Time to CV Death
Time Frame: Up to 4 years
Time to CV death will be reported.
Up to 4 years
Time to the First Occurrence of Composite Endpoint of All-cause Death, MI, Stroke and Non-CNS Systemic Embolism
Time Frame: Up to 4 years
Time to the first occurrence of composite endpoint of all-cause death, MI, stroke and Non-CNS systemic embolism will be reported.
Up to 4 years
Time to the First Occurrence of Composite Endpoint of CV Death, MI, Stroke, Acute Limb Ischemia (ALI), and Urgent Hospitalization for Vascular cause of Ischemic Nature
Time Frame: Up to 4 years
Time to the first occurrence of composite endpoint of CV death, MI, stroke, ALI [any unanticipated revascularization or amputation of ischemic limb]), and urgent hospitalization for vascular cause of ischemic nature (including deep vein thrombosis [DVT] and pulmonary embolism [PE]) will be reported.
Up to 4 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Collaborators

Investigators

  • Study Director: Janssen Research & Development, LLC Clinical Trial, Janssen Research & Development, LLC

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 11, 2023

Primary Completion (Estimated)

March 5, 2027

Study Completion (Estimated)

May 5, 2027

Study Registration Dates

First Submitted

February 24, 2023

First Submitted That Met QC Criteria

February 24, 2023

First Posted (Actual)

March 7, 2023

Study Record Updates

Last Update Posted (Actual)

April 24, 2024

Last Update Submitted That Met QC Criteria

April 23, 2024

Last Verified

April 1, 2024

More Information

Terms related to this study

Other Study ID Numbers

  • CR109220
  • 70033093AFL3002 (Other Identifier: Janssen Research & Development, LLC)
  • 2022-501419-15-00 (Registry Identifier: EUCT number)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

The data sharing policy of the Janssen Pharmaceutical Companies of Johnson & Johnson is available at www.janssen.com/clinical-trials/transparency. As noted on this site, requests for access to the study data can be submitted through Yale Open Data Access (YODA) Project site at yoda.yale.edu

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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