- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05780463
MP0420 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)
A Multicenter, Adaptive, Randomized, Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for Hospitalized Patients With COVID-19 (Trial H5: MP0420)
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
This is a treatment trial of the ACTIV-3/TICO master protocol (NCT04501978) to evaluate the safety and efficacy of MP0420 in hospitalized patients infected with COVID-19.
This is a randomized, blinded, controlled sub-study of MP0420 plus current SOC against placebo plus current SOC. The placebo arm may be shared across other sub-studies of the ACTIV-3/TICO master protocol. When more than one drug is being tested at the same time, participants will be randomly allocated to treatments or placebo.
Randomization will be stratified by study site pharmacy and disease severity. There are 2 disease severity strata: participants without organ failure (severity stratum 1) and participants with organ failure (severity stratum 2).
An independent Data and Safety Monitoring Board (DSMB) will regularly review interim analyses and summarize safety and efficacy outcomes. The pace of enrollment with be initially restricted, and there will be an early review of safety data by the DSMB. At the outset of the trial, only participants in disease severity stratum 1 will be enrolled. This will continue until approximately 300 participants are enrolled and followed for 5 days. The exact number will vary according to the speed of enrollment and the timing of DSMB meetings. Prior to expanding enrollment to also include patients in disease severity stratum 2, safety will be evaluated and a pre-specified futility assessment by the DSMB will be carried out using 2 ordinal outcomes assessed at Day 5.
If MP0420 passes the futility assessment, enrollment of participants will be expanded, seamlessly and without any data unblinding, to include participants in disease severity stratum 2 as well as those in disease severity stratum 1. Future interim analyses will be based on the primary endpoint of sustained recovery and will use pre-specified guidelines to determine early evidence of benefit, harm, or futility for the investigational agent. Participants will be followed for 18 months following randomization.
This trial will be conducted in several hundred clinical sites. Participating sites are affiliated with networks funded by the United States National Institutes of Health (NIH) and the US Department of Veterans Affairs.
Study Type
Enrollment (Actual)
Phase
- Phase 3
Contacts and Locations
Study Locations
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Aalborg, Denmark, 9000
- Aalborg Hospital (Site 625-005), Hobrovej 18
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Aarhus N, Denmark, 8200
- Aarhus Universitetshospital, Skejby (Site 625-002), Department of Infectious Diseases, Palle Juul-Hensens Boulevard 99
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Copenhagen, Denmark, 2400
- Bispebjerg Hospital (Site 625-013), Bispebjerg Bakke 23
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Copenhagen Ø, Denmark, 2100
- Righospitalet (Site 625-006), Blegdamsvej 9,
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Herlev, Denmark, 2730
- Herlev/Gentofte Hospital (Site 625-012), Medicinsk Afdeling, Herlev Ringvej 75
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Hillerød, Denmark, 3400
- Nordsjællands Hospital (Site 625-009), Dyrehavevej 29
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Hvidovre, Denmark, 2650
- Hvidovre University Hospital, Department of Infectious Diseases (Site 625-001), Kettegård allé 30
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Kolding, Denmark, 6000
- Kolding Sygehus (Site 625-011), Medicinsk Afdeling, Sygehusvej 24
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Odense, Denmark, 5000
- Odense University Hospital (Site 625-004), Infektionsmedicinsk Forskningsenhed, J.B. Winsløwsgade 4
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Roskilde, Denmark, 4000
- Zealand University Hospital, Roskilde (Site 625-010), Sygehusvej 10
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Athens, Greece, 106 76
- Evangelismos COVID-19 Unit, (Site 635-020), 1st Dept. of Pulmonary and Critical Care Medicine, Evangelismos General Hospital, Dept., Ipsilantou 45-47
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Athens, Greece, 115 27
- 1st Respiratory Medicine Dept., Athens University Medical School (Site 635-015), Athens Hospital for Diseases of the Chest "Sotiria Hospital", 152 Mesogeion Ave.
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Athens, Greece, 115 27
- 3rd Dept. of Medicine, Medical School, NKUA (Site 635-022), Sotiria General Hospital, 152 Mesogeion Ave.
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Athens, Greece, 124 62
- Attikon University General Hospital (Site 635-009), 4th Dept. of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 1 Rimini St., Haidari
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Evros
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Alexandroupolis, Evros, Greece, 68131
- Democritus University of Thrace (Site 635-021), University General Hospital of Alexandroupolis, Dragana
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Abuja, Nigeria
- Institute of Human Virology Nigeria (IHVN) (Site 612-601), Plot 252, Herbert Macaulay Way, Central Business District
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Warsaw, Poland, 01-201
- Wojewódzki Szpital Zakazny (Site 625-302), Wolska 37
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Singapore, Singapore, 308433
- Tan Tock Seng Hospital (Site 612-201), National Centre for Infectious Diseases (NCID), 11 Jalan Tan Tock Seng
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Barcelona, Spain, 08003
- Hospital Del Mar (Site 626-025), Paseo Maritimo 25-29
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Barcelona, Spain, 08036
- Hospital Clinic de Barcelona (Site 626-004), Carrer de Villaroel 170
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Barcelona
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Badalona, Barcelona, Spain, 08916
- Hospital Universitari Germans Trias i Pujol (Site 626-003), Infectious Disease Unit, Second Floor, Building Maternal, Road Canyet s/n
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Leida
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Lleida, Leida, Spain, 25198
- Hospital Universitari Arnau de Vilanova (Site 626-035), Av. Alcalde Rovira Roure 80
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Zurich
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Zürich, Zurich, Switzerland, 8091
- University Hospital Zurich (Site 621-201), Department of Infectious Diseases and Hospital Epidemiology, Raemistrasse 100
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Entebbe, Uganda
- MRC/UVRI and LSHTM Uganda Research Unit (Site 634-601), Entebbe Regional Referral Hospital
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Gulu, Uganda
- Gulu Regional Referral Hospital (Site 634-603), Laroo Division, PO Box 160
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Kampala, Uganda
- Makerere University Lung Institute (Site 634-604), New Mulago Hospital Complex, Mulago Hill
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Kampala, Uganda
- St. Francis Hospital, Nsambya (Site 634-607), Nsambya Road Nsambya Hill, P.O. Box 7146
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Lira, Uganda
- Lira Regional Referral Hospital (Site 634-605)
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Masaka, Uganda
- Masaka Regional Referral Hospital (Site 634-606), MRC/UVRI and LSHTM Uganda Research Unit, Plot 6 Circle Road, PO Box 556
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London, United Kingdom, NW3 2QG
- Royal Free Hospital (Site 634-006), Pond Street, Hampstead
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London, United Kingdom, SE1 7EH
- Guy's and St. Thomas' NHS Foundation Trust (Site 634-011)
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Northumbria
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Newcastle Upon Tyne, Northumbria, United Kingdom, NE1 4LP
- Royal Victoria Infirmary (Site 634-007), Queen Victoria Road
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Arizona
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Tucson, Arizona, United States, 85719
- Banner University Medical Center Tucson (Site 206-004), 1625 N. Campbell Avenue
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Tucson, Arizona, United States, 85723
- Southern Arizona VA Healthcare System (Site 074-009), 3601 S. 6th Ave.
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California
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Chula Vista, California, United States, 91911
- Velocity Chula Vista (Site 080-034), 752 Medical Center Ct., Ste. 304
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Fresno, California, United States, 93701
- Community Regional Medical Center (Site 203-005), 2823 Fresno Street
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La Mesa, California, United States, 91942
- Velocity San Diego (Site 080-035), 5565 Grossmont Center Drive, Building 2, Suite 1
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Long Beach, California, United States, 90822
- VA Long Beach Healthcare System (Site 074-026), 5901 East 7th Street (09/151-M2)
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Los Angeles, California, United States, 90048
- Cedars-Sinai Medical Center (Site 208-002), 8700 Beverly Blvd.
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Los Angeles, California, United States, 90095
- Ronald Reagan UCLA Medical Center (Site 203-002), 757 Westwood Plaza
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Mather, California, United States, 95655
- Sacramento VA Medical Center (Site 074-023), 10535 Hospital Way
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Newport Beach, California, United States, 92663
- Hoag Memorial Hospital Presbyterian (Site 080-026), One Hoag Drive
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Sacramento, California, United States, 95817
- UC Davis Health (Site 203-004), 2315 Stockton Blvd.
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San Diego, California, United States, 92161
- VA San Diego Healthcare System (Site 074-016), 3350 La Jolla Village Drive
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San Francisco, California, United States, 94115
- UCSF Medical Center at Mount Zion (Site 203-007), 1600 Divisadero St.
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San Francisco, California, United States, 94121
- San Francisco VAMC (Site 074-002), 4150 Clement St.
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San Francisco, California, United States, 94143
- UCSF Medical Center (Site 203-001), Moffitt-Long Hospital, 505 Parnassus Ave.
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Stanford, California, United States, 94305
- Stanford University Hospital & Clinics (Site 203-003), 300 Pasteur Dr.
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Torrance, California, United States, 90502
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (Site 066-002), 1124 W. Carson Street, CDCRC Building
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Colorado
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Aurora, Colorado, United States, 80045
- University of Colorado Hospital (Site 204-001), 12605 E. 16th Avenue
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Denver, Colorado, United States, 80204
- Denver Public Health (Site 017-004), 660 Bannock St., MC2600 (Infectious Disease Clinic)
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Connecticut
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West Haven, Connecticut, United States, 06516
- West Haven VA Medical Center (Site 025-007), 950 Campbell Avenue
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District of Columbia
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Washington, District of Columbia, United States, 20010
- MedStar Health Research Institute (Site 009-021), MedStar Washington Hospital Center, 110 Irving St., NW.
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Washington, District of Columbia, United States, 20422
- Washington DC VA Medical Center (Site 009-004), 50 Irving Street NW
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Florida
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Bay Pines, Florida, United States, 33744
- Bay Pines VAMC (Site 074-004), 10000 Bay Pines Blvd., Bldg. 100, Room 5B-104
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Miami, Florida, United States, 33125
- Miami VAMC (Site 074-003), 1201 NW 16 Street
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Tampa, Florida, United States, 33602
- Hillsborough County Health Department, University of South Florida (Site 032-001)
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Georgia
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Atlanta, Georgia, United States, 30322
- Emory University (Site 301-008), The Emory Clinic, Bldg. A, Suite 2236, 1365 Clifton Rd., NE
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Indiana
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Fort Wayne, Indiana, United States, 46804
- Lutheran Medical Group (Site 301-010), 7916 W. Jefferson Boulevard
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Kansas
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Topeka, Kansas, United States, 66604
- Cotton O'Neil Clinical Research Center (Site 080-030), Stormont Vail Health, 1500 SW 10th Avenue
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Louisiana
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New Orleans, Louisiana, United States, 70121
- Ochsner Clinic Foundation (Site 301-015), 1514 Jefferson Highway
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Maryland
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Baltimore, Maryland, United States, 21201
- University of Maryland Medical Center (Site 301-019), 22 South Greene Street
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Massachusetts
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Boston, Massachusetts, United States, 02114
- Massachusetts General Hospital (Site 202-002), 55 Fruit Street
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Boston, Massachusetts, United States, 02215
- Beth Israel Deaconess Medical Center (Site 202-001), 330 Brookline Ave.
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Springfield, Massachusetts, United States, 01199
- Baystate Medical Center (Site 201-001), 759 Chestnut Street
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Michigan
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Ann Arbor, Michigan, United States, 48109
- University of Michigan (Site 205-001), 1500 East Medical Center Drive
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Detroit, Michigan, United States, 48202
- Henry Ford Health System, Henry Ford Hospital (Site 014-001), 2799 W. Grand Blvd.
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Minnesota
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Minneapolis, Minnesota, United States, 55407
- Minneapolis Heart Institute Foundation (Site 301-026), Abbott Northwestern Hospital, 920 E 28th St. #100
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Minneapolis, Minnesota, United States, 55415
- Hennepin Healthcare (Site 027-001), 701 Park Avenue
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Minneapolis, Minnesota, United States, 55417
- Minneapolis VA Health Care System (Site 105-001), 1 Veterans Drive, Bldg 70
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Minneapolis, Minnesota, United States, 55455
- M Health Fairview University of Minnesota Medical Center (Site 112-001), 500 Harvard St. SE.
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Mississippi
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Jackson, Mississippi, United States, 39216
- University of Mississippi Medical Center (Site 202-005), 2500 North State Street
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New Hampshire
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Lebanon, New Hampshire, United States, 03756
- Dartmouth-Hitchcock Medical Center/Mary Hitchcock Memorial Hospital (Site 301-024), One Medical Center Drive
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New Jersey
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Camden, New Jersey, United States, 08103
- Cooper University Hospital (Site 019-001), One Cooper Plaza
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New York
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Bronx, New York, United States, 10451
- Lincoln Medical Center (New York Health and Hospitals/Lincoln) (Site 003-016), 234 E. 149th Street
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Bronx, New York, United States, 10467
- Montefiore Medical Center Moses Hospital (Site 206-001), 111 E. 210th Street
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Brooklyn, New York, United States, 11203
- SUNY Downstate Medical Center (Site 033-001), 450 Clarkson Ave.
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Brooklyn, New York, United States, 11219
- Maimonides Medical Center (Site 033-002), 4802 10th Avenue
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North Carolina
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Durham, North Carolina, United States, 27710
- Duke University Hospital (Site 301-006), 2301 Erwin Road
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Winston-Salem, North Carolina, United States, 27157
- Wake Forest University Health Sciences (Site 210-001), Medical Center Blvd
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Ohio
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Cincinnati, Ohio, United States, 45219
- University of Cincinnati Medical Center (Site 207-003), 234 Goodman Ave.
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Cleveland, Ohio, United States, 44106
- University Hospitals Cleveland Medical Center (Site 108-001), 11100 Euclid Avenue
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Oregon
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Portland, Oregon, United States, 97239-3098
- Oregon Health & Science University (Site 208-003), 3181 SW Sam Jackson Park Rd.
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Portland, Oregon, United States, 97239
- Portland VA Healthcare System (Site 074-024), 3710 SW. US Veterans Hospital Road
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Rhode Island
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Providence, Rhode Island, United States, 02903
- Rhode Island Hospital (Site 080-036), 593 Eddy Street
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Providence, Rhode Island, United States, 02906
- The Miriam Hospital (Site 080-039), 164 Summit Ave.
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South Carolina
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Charleston, South Carolina, United States, 29401
- Ralph H. Johnson VA Medical Center (Site 074-015), 109 Bee Street
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Charleston, South Carolina, United States, 29425
- MUSC Research Nexus Clinic (Site 210-002), 96 Jonathan Lucas St., CSB 214
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Florence, South Carolina, United States, 29505
- MUSC Health Florence Medical Center (Site 210-006), 805 Pamplico Highway
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Tennessee
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Nashville, Tennessee, United States, 37212
- VA TVHS Nashville Campus (Site 074-022), 1310 24th Avenue South
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Nashville, Tennessee, United States, 37232
- Vanderbilt University Medical Center (Site 212-001), 1211 Medical Center Drive
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Texas
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Abilene, Texas, United States, 79601
- Hendrick Medical Center (Site 080-014), 1900 Pine Street
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Corpus Christi, Texas, United States, 78404
- CHRISTUS Spohn Shoreline Hospital (Site 080-001), 600 Elizabeth Street
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Dallas, Texas, United States, 75235
- Parkland Health and Hospital Systems (Site 084-002), 5200 Harry Hines Blvd
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Dallas, Texas, United States, 75235
- UT Southwestern Medical Center (Site 084-001), 1936 Amelia Court, 2nd Floor
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Dallas, Texas, United States, 75246
- Baylor, Scott and White Health (Site 301-003), Baylor University Medical Center, 3500 Gaston Ave.
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Houston, Texas, United States, 77030
- Michael E. DeBakey Veterans Affairs Medical Center (MEDV AMC) (Site 074-006), 2002 Holcombe Blvd.
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Houston, Texas, United States, 77030
- Texas Heart Institute (Site 301-017), 6770 Bertner, MC4-266
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Longview, Texas, United States, 75601
- CHRISTUS Good Shepherd Medical Center (Site 080-031), 700 E. Marshall Ave.
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Utah
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Murray, Utah, United States, 84107
- Intermountain Medical Center (Site 211-001), 5121 South Cottonwood Street
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Virginia
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Charlottesville, Virginia, United States, 22903
- University of Virginia Health Systems (Site 301-021), 1215 Lee Street
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Roanoke, Virginia, United States, 24014
- Carilion Roanoke Memorial Hospital (Site 080-018), 1906 Belleview Avenue
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Salem, Virginia, United States, 24153
- Salem VA Medical Center (Site 074-014), 1970 Roanoke Blvd.
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Washington
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Seattle, Washington, United States, 98122
- Swedish Hospital First Hill (Site 208-005), 747 Broadway
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West Virginia
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Morgantown, West Virginia, United States, 26506
- West Virginia University (Site 301-023), One Medical Center Drive
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria: Refer to the master protocol (NCT04501978)
Exclusion Criteria: Refer to the master protocol (NCT04501978)
Additional Exclusion Criteria:
- Pregnant women
- Nursing mothers
- Women of child-bearing potential who are unwilling to acknowledge the strong advice to abstain from sexual intercourse with men or practice appropriate contraception through 11 weeks after receiving MP0420/placebo
- Men who are unwilling to acknowledge the strong advice to abstain from sexual intercourse with women of child-bearing potential or to use barrier contraception through 11 weeks after receiving MP0420/placebo.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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Experimental: MP0420 plus SOC
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MP0420 is a multi-valent DARPin® molecule (designed ankyrin repeat protein), consisting of 5 DARPin® domains.
Other Names:
Antiviral agent
Other Names:
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Placebo Comparator: Placebo plus SOC
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Antiviral agent
Other Names:
Commercially available 0.9% sodium chloride solution
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Number of Participants With Sustained Recovery
Time Frame: Through Day 90
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Sustained recovery defined as being discharged from the index hospitalization, followed by being alive and home for 14 consecutive days prior to Day 90.
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Through Day 90
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Number of Participants With an Ordinal Outcome on Day 5
Time Frame: Status on Day 5
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Ordinal outcome with 7 mutually exclusive categories
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Status on Day 5
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Number of Participants Who Died From All Causes
Time Frame: Through Day 90
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All-cause mortality
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Through Day 90
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Number of Participants With a Safety Outcome Through Day 5
Time Frame: Through Day 5
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Death, SAE, clinical organ failure, serious infections, or Grade 3 or 4 event through Day 5
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Through Day 5
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Number of Participants With a Safety Outcome Through Day 28
Time Frame: Through Day 28
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Death, SAE, clinical organ failure, serious infections, or Grade 3 or 4 event through Day 28
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Through Day 28
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Number of Participants With a Safety Outcome Through Day 90
Time Frame: Through Day 90
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Death, SAE, clinical organ failure, serious infections through Day 90
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Through Day 90
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Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Jens Lundgren, Prof., INSIGHT Copenhagen International Coordinating Centre, Rigshospitalet, University of Copenhagen
- Study Chair: James Neaton, Prof., INSIGHT Statistical and Data Management Center, University of Minnesota
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Coronavirus Infections
- Coronaviridae Infections
- Nidovirales Infections
- RNA Virus Infections
- Virus Diseases
- Infections
- Respiratory Tract Infections
- Respiratory Tract Diseases
- Pneumonia, Viral
- Pneumonia
- Lung Diseases
- COVID-19
- Molecular Mechanisms of Pharmacological Action
- Anti-Infective Agents
- Antiviral Agents
- Antimetabolites
- Remdesivir
Other Study ID Numbers
- 014/ACTIV-3/H5
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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