Significance of Platelet Indices and Ratios in Different Degrees of Burn

September 23, 2024 updated by: Lubna Mansour Shhat Wahba, Assiut University
Study the correlation between the platelet indices and different degrees of burn Study the correlation between the platelet ratios and different degrees of burn.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

Burns are a major traumatic pathology characterized by tissue destruction and cellular degradation resulted by energy transfer and mainly affect skin, which serve as significant cause of morbidity and mortality. burns are classified as first,second and third degree depending on how deep and severe they penetrate the skin surface.

Platelets play important role in primary homeostasis, thrombosis, inflammation and tissue regulation in the processes of wound healing. Platelets can contact exposed collagen and extra cellular matrix and releasing clotting factors to achieve homeostasis as well as essential growth factors and cytokines to repair the wound.In clinical, Platelet-rich plasma (PRP) is a concentrate of autologous platelets,has been used to effectively accelerate burn wound healing Platelet indices (PI), markers of platelet activation, are parameters obtained daily as a part of an automatic blood count, Platelet indices are related to platelets morphology and proliferation kinetics. Most commonly assessed platelet indices include the mean platelet volume (MPV), mean distribution width(PDW),Platelet larger cell ratio (PLCR) ,platelet crit (PCT), mean platelet mass (MPM),mean platelet component (MPC),Platelet component distribution width (PCDW) and immature platelet fraction (IPF).

The ratio of red blood cell distribution width (RWD) and platelet (PLT) (RPR) is considered an inflammation biomarker associated with the poor prognosis of number of diseases. There is two studies about PRP related to prognosis of major burn injury . results indicate that RPR-as an inflammatory index- can be used as a biomarker for prognosis of adult patients with major burn injuries.

Blood-based platelet parameters, due to their fairly easy accessibility and inexpensive methods of measurement, seem to be on the rise as potential novel biomarkers of numerous ,both acute and chronic disease. However, To date ,there are no data on the significance of platelets indices in evaluation with different degrees of burn .In this study we will evaluate the significance of platelet ratios and indices in different degrees of burn.

Study Type

Observational

Enrollment (Estimated)

333

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Study the correlation between the platelet indices and different degrees of burn Study the correlation between the platelet ratios and different degrees of burn.

Description

Inclusion Criteria:

  • burn degree ( 1,2,3)

Exclusion Criteria:

  • patient with ITB

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Significance of platelet indices in different degrees of burn
Time Frame: basline
Study the correlation between the platelet indices and different degrees of burn
basline
Significance of platelet ratios in different degrees of burn
Time Frame: basline
Study the correlation between the platelet ratios and different degrees of burn.
basline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

October 10, 2024

Primary Completion (Estimated)

September 1, 2025

Study Completion (Estimated)

November 1, 2025

Study Registration Dates

First Submitted

September 9, 2024

First Submitted That Met QC Criteria

September 23, 2024

First Posted (Actual)

September 25, 2024

Study Record Updates

Last Update Posted (Actual)

September 25, 2024

Last Update Submitted That Met QC Criteria

September 23, 2024

Last Verified

September 1, 2024

More Information

Terms related to this study

Other Study ID Numbers

  • PltIs and PltR in burn degrees

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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