Intelligent Accelerated MRI for Pediatric Abdominal Pain (IA-MRI)

September 9, 2025 updated by: Yaqi Shen，MD，PhD

Prospective Application Study of Intelligent Accelerated Magnetic Resonance Imaging in Children With Abdominal Pain

The goal of this observational study is to evaluate the effectiveness of an intelligent accelerated MRI technique in children with abdominal pain. The main question it aims to answer is:

Does the intelligent accelerated MRI reduce scan time while maintaining diagnostic accuracy in pediatric patients?

Participants will:

Receive an abdominal MRI scan using the accelerated protocol as part of their clinical evaluation.

Have their scan duration and image quality compared to conventional MRI standards.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Detailed Description

The goal of this prospective observational study is to evaluate the effectiveness and feasibility of an intelligent accelerated MRI scanning technique in pediatric patients presenting with abdominal pain. The main questions it aims to answer are:

Can the intelligent accelerated MRI technique achieve comparable or superior image quality to conventional MRI while significantly reducing scan time?

Does the accelerated scanning protocol reduce motion artifacts and improve diagnostic accuracy in pediatric patients?

Participants will:

Undergo an intelligent accelerated MRI scan of the abdomen as part of their diagnostic workup.

Have their scan duration, image quality, and diagnostic outcomes compared to historical or conventional MRI data (if available).

Why this study? Abdominal pain is a common pediatric complaint with diverse causes. While MRI is a non-invasive, radiation-free diagnostic tool, its utility in children is limited by long scan times and motion artifacts. This study investigates a novel intelligent accelerated MRI sequence that promises faster scans without compromising quality. Validating this technology in children could transform MRI's role in diagnosing abdominal pain by improving patient comfort, reducing sedation needs, and enhancing diagnostic accuracy.

Ethical approval: Conducted at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, with oversight by the Institutional Ethics Committee.

Key innovation: Leveraging cutting-edge AI-driven acceleration to address pediatric imaging challenges. If successful, this approach could set a new standard for rapid, child-friendly MRI diagnostics.

Study Type

Observational

Enrollment (Estimated)

150

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Hubei
      • Wuhan, Hubei, China, 430030
        • Tongji Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

The study population consists of pediatric patients aged 3-18 years presenting with abdominal pain who have undergone a prior abdominal CT examination as part of their clinical evaluation. Eligible participants must have guardians who voluntarily consent to an additional MRI scan and provide written informed consent.

Description

Inclusion Criteria:

  • Children aged 3-18 years presenting with abdominal pain who have undergone abdominal CT examination.
  • Children whose guardians voluntarily agree to MRI examination and sign written informed consent.

Exclusion Criteria:

  • Children with contraindications to MRI (e.g., metal implants, severe claustrophobia) or those unable to cooperate with the examination.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
1
Pediatric patients who were undergoing MRE examination for abdominal pain
Other: Accelerated MRI scanning

All patients underwent MRI scans of the abdominal and pelvic regions on the uMR 790 scanner at Tongji Hospital's Optical Valley Campus. The scanning protocol included multiplanar ACS T2WI sequences, TACS T2WI sequences, and conventional T2WI sequences.

ACS T2WI sequence: Used for preliminary motion artifact correction. TACS T2WI sequence: Employed for advanced motion artifact correction and provided dynamic images of organ movement.

Conventional T2WI sequence: Served as the standard reference for comparison.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Scan Time Reduction with Intelligent Accelerated MRI
Time Frame: During MRI scan procedure (single time point).
Comparison of total scan time (minutes) for abdominal/pelvic MRI using the intelligent accelerated protocol (ACS-T2WI and TACS-T2WI sequences) versus conventional T2WI sequences, while maintaining diagnostic image quality (assessed by radiologists using a 5-point Likert scale).
During MRI scan procedure (single time point).

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Diagnostic Accuracy of Accelerated MRI
Time Frame: Within 24 hours post-scan.
Diagnostic concordance rate (%) between intelligent accelerated MRI and conventional MRI for identifying causes of abdominal pain (e.g., appendicitis, bowel obstruction), validated against final clinical/histopathological diagnoses.
Within 24 hours post-scan.
Motion Artifact Reduction
Time Frame: During MRI scan procedure (single time point).
Quantitative evaluation of motion artifacts in accelerated MRI scans (ACS-T2WI and TACS-T2WI) compared to conventional T2WI, scored by two blinded radiologists using a 4-point scale (1 = severe artifacts; 4 = minimal/no artifacts).
During MRI scan procedure (single time point).

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Yaqi Shen，MD，PhD

Collaborators

United Imaging Healthcare

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 26, 2025

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2027

Study Registration Dates

First Submitted

September 2, 2025

First Submitted That Met QC Criteria

September 9, 2025

First Posted (Estimated)

September 10, 2025

Study Record Updates

Last Update Posted (Estimated)

September 10, 2025

Last Update Submitted That Met QC Criteria

September 9, 2025

Last Verified

September 1, 2025

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • TJ-IRB202410027
  • 82471969 (Other Grant/Funding Number: National Natural Science Foundation of China (NSFC))

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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