Assessment of the Effects of a Daily Supplement 4Life Transfer Factor Vista Containing AREDS2 Formula on Skin Carotenoid Levels Using a Non-invasive Detection

Assessment of the Effects of a Daily Supplement 4Life Transfer Factor Vista Containing the AREDS2 Formula on Skin Carotenoid Levels Using a Non-Invasive Method

The goal of the clinical study is to evaluate the impact of daily use of a dietary supplement TF Vista containing AREDS2 formula ingredients, astaxanthin (Haematococcus pluvialis) microalgae, bilberry (Vaccinium myrtillus) fruit powder and black currant (Ribes nigrum) fruit powder organic on skin carotenoid levels over an 8-week period for a Cohort 1(n= 20 participants) and 12 weeks for a Cohort 2 (n= 4 participants). Results will be compared using two devices - the Veggie Meter and the Samsung Watch - both of which utilize reflection spectroscopy technology. For Cohort 2 (n = 4 participants), in addition to assessing skin carotenoid levels, the study will also evaluate changes in macular pigment optical density (MPOD) before and after supplementation.

Study Overview

• Status: Completed
• Conditions: Skin Carotenoids
• Intervention / Treatment: Other: Dietary Supplement

• Study Type: Interventional
• Enrollment (Actual): 24
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Utah
    • Sandy City, Utah, United States, 84070
      • 4Life Research

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Healthy subjects ≥ 18 years of age. Committed to maintain the same eating, exercise, and other lifestyle routines for the whole duration of the study.

Exclusion Criteria:

• • Pregnant and/or lactating women or planning to become pregnant in the following 12 weeks.
• Participants were not allowed to participate if they have a known allergy or adverse reaction to any of the ingredients in the study product.
• Participants were not allowed to participate if they have used AREDS2 formula products over the past 6 months.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: 4lLife TF Vista; Participants were supplied with two bottles of the study product (for Cohort-1) and three bottles (for Cohort-2) labeled with the participant number during the study. They were required to take the product consisting of 4 capsules per day, taken with 8 oz. of fluid and preferably with a meal.	Other: Dietary Supplement; Study product 4Life TF Vista contains Tri Factor (bovine colostrum and egg yolk), bilberry (Vaccinium myrtillus) fruit powder, black currant (Ribes Nigrum) powder, lutein, zeaxanthin (Tagetes erecta), vitamin C, vitamin A, vitamin E, zinc, and copper.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Skin Carotenoid Levels	Skin carotenoid levels measured via a portable Veggie Meter, Longevity Link Corp. device using reflection spectroscopy on a participant's fingerprint.	From enrollment to the end of treatment at 8 weeks for Cohort-1 and 12 weeks for Cohort-2

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Antioxidant Levels	Antioxidant levels assessed by a Samsung Watch device via skin absorption spectra. The bioactive sensor measures reflected light after emitting LED light. The test requires the participant to press the thumb on the sensor for a few seconds to get a reading.	From enrollment to the end of treatment at 8 weeks for Cohort-1 and 12 weeks for Cohort-2.

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Macular Pigment Optical Density (MPOD)	Macular Pigment Optical Density (MPOD) testing measurement of the density of the light-absorbing pigments in the center of the retina. This tests is performed only for participants in Cohort-2.	At enrollment and at the end of the treatment (week-12)
Visual Acuity Test	Visual Acuity Test to measure sharpest vision using a Snellen eye chart, to determine the smallest detail a participant can see from 20 feet distance. Test will be performed only for participants included in Cohort-1	From enrollment to the end of treatment at 8 weeks.
Amsler Grid Chart Test	Amsler Grid Chart Test to monitor central vision for changes like way, blurry, or missing lines. Test performed only on participants included in Cohort-1.	From enrollment to the end of treatment at 8 weeks.
Visual Functioning Questionnaire-25 (VFQ-25)	Visual Functioning Questionnaire-25 (VFQ-25) to assess participants self-reported vision- related quality of life. For participants included in Cohort-1.	From enrollment to the end of treatment at 8 weeks.

Collaborators and Investigators

• Sponsor: 4Life Research, LLC
• Investigators: Principal Investigator: David Vollmer, 4Life Research

Study record dates

Study Major Dates

• Study Start (Actual): October 16, 2025
• Primary Completion (Actual): December 17, 2025
• Study Completion (Actual): February 14, 2026

Study Registration Dates

• First Submitted: March 31, 2026
• First Submitted That Met QC Criteria: March 31, 2026
• First Posted (Actual): April 7, 2026

Study Record Updates

• Last Update Posted (Actual): April 7, 2026
• Last Update Submitted That Met QC Criteria: March 31, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages; Dietary Supplements
• Other Study ID Numbers: 4LIFE2026-001

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No