Efficacy of Selective COX-2 Inhibitors in Relieving Orthodontic Pain (EOSCOX2)

April 23, 2026 updated by: Sharif Medical Research Center

Efficacy of Selective COX-2 Inhibitors in Relieving Orthodontic Pain ;a Randomized Controlled Trial

The purpose of this study is to compare the efficacy of selective COX-2 inhibitors{ etoricoxib vs celecoxib )in relieving orthodontic pain , after initial bonding and arch wire insertion.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

150

Phase

  • Phase 1

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Pakistan
      • Lahore, Pakistan
        • Sharif Medical City Lahore

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  1. Age 13 to 30 years
  2. Fully erupted permanent dentition excluding third molars
  3. Mild crowding (0 -4mm)

Exclusion Criteria:

  1. Active periodontitis
  2. Deep cavities or large restorations
  3. Previous dental extraction in less than 4 weeks before bonding
  4. History of steroid use within last 6 weeks

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Supportive Care
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Group A
Group A will be given Celecoxib medicine.
Drug: Celecoxib
Group A will be given Celecoxib 50mg once a day.
Active Comparator: Group B
Group B will be given Etoricoxib medicine.
Drug: Etoricoxib (Treatment Group)
Group B will be given Etoricoxib 60mg once a day.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Pain intensity
Time Frame: 1 year
Pain scores will be measured using a 10cm Visual Analogue Scale (VAS) , The Scale consists of a horizontal line anchored by two verbal descriptions where 0 represented '' No Pain '' and 10 represented ''Maximum Pain''. The Score is determined by measuring the distance from left end of the scale to the mark made by the participant.
1 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sharif Medical Research Center

Investigators

  • Study Chair: Faiza Malik, BDS, FCPS, Essentia Health

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 8, 2025

Primary Completion (Actual)

August 18, 2025

Study Completion (Estimated)

April 30, 2026

Study Registration Dates

First Submitted

April 14, 2026

First Submitted That Met QC Criteria

April 23, 2026

First Posted (Actual)

April 30, 2026

Study Record Updates

Last Update Posted (Actual)

April 30, 2026

Last Update Submitted That Met QC Criteria

April 23, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • SMDC/SMRC/289-23

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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