A Comparative Study of Preoperative Carbohydrate Loading Dose and Fasting on Postoperative Recovery Time in Elective Abdominal Surgery Patients
Title: A Comparative Study of Preoperative Carbohydrate Loading Dose and Fasting on Postoperative Recovery Time in Elective Abdominal Surgery Patients
Study Overview
Status
Detailed Description
Preoperative fasting has traditionally been practiced to reduce the risk of aspiration during anesthesia; however, prolonged fasting may lead to increased insulin resistance, patient discomfort, and delayed postoperative recovery. Recent evidence suggests that preoperative carbohydrate loading may improve metabolic response and enhance recovery after surgery.
This single-center randomized controlled trial will be conducted on 144 patients admitted for elective abdominal surgery. Eligible participants will be randomly allocated into two groups: the intervention group will receive a standardized preoperative carbohydrate drink within a defined time before surgery, while the control group will follow conventional fasting guidelines.
The primary outcome of the study is postoperative recovery time, assessed using clinically relevant recovery parameters. Secondary outcomes include length of hospital stay, incidence of postoperative complications, and patient-reported comfort measures.
Data will be collected prospectively during hospital stay and analyzed to determine whether preoperative carbohydrate loading provides significant benefits over standard fasting protocols. The results of this study may contribute to improving perioperative care practices and updating fasting guidelines in surgical patients.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
• Patients aged 20-60
- ASA I-II classification.
- Elective open or laparoscopic abdominal surgeries.
Exclusion Criteria:
• Diabetes mellitus or impaired fasting glucose.
- Emergency surgeries.
- Patients with hepatic or renal dysfunction.
- Patients on corticosteroids or insulin-sensitizing agents.
- Pregnant patients.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Supportive Care
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Experimental: Pre operative carbohydrate Loading group
Patients in this group will receive a preoperative carbohydrate-rich clear liquid drink before elective abdominal surgery to reduce insulin resistance, improve postoperative recovery, and decrease discomfort associated with prolonged fasting.
|
Most previous studies have evaluated preoperative carbohydrate loading in mixed surgical populations or in settings outside Pakistan. Limited local data exist specifically for elective abdominal surgery patients in a single-center Pakistani tertiary care hospital setting. Thisstudy focuses on comparing a standardized carbohydrate loading dose with conventional fasting and assessing its direct impact on postoperative recovery time in your local population. surgery patients specifically It uses a standardized carbohydrate loading dose It compares against the routinely practiced prolonged fasting protocol It is conducted in a single-center local hospital population, where local evidence is limited It focuses on postoperative recovery time as the primary clinical outcome |
|
Active Comparator: Standard preoperative fasting group
Patients in this group will follow the routine preoperative fasting protocol as per hospital practice, including overnight fasting from solids and clear liquids according to standard anesthetic guidelines before elective abdominal surgery.
No preoperative carbohydrate drink will be administered.
Postoperative recovery outcomes will be compared with the intervention group receiving preoperative carbohydrate loading.
|
Patients in this group will follow the routine preoperative fasting protocol according to hospital and anesthesia guidelines, including overnight fasting from solids and clear liquids before elective abdominal surgery.
No preoperative carbohydrate loading will be give
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Post operative insuline resistance
Time Frame: 24 hours after surgery
|
To evaluate the effect of preoperative oral carbohydrate loading compared with standard fasting on postoperative insulin resistance in patients undergoing elective abdominal surgery.
Insulin resistance will be assessed by measuring fasting blood glucose and serum insulin levels preoperatively and postoperatively, and calculating insulin resistance using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR).
|
24 hours after surgery
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Time to first oral intake
Time Frame: 24 hours after surgery
|
To compare the duration from completion of surgery until the patient tolerates first oral intake (clear fluids or oral diet) between the preoperative carbohydrate loading group and the standard fasting group.
This outcome reflects early postoperative gastrointestinal recovery and readiness for oral feeding.
|
24 hours after surgery
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Estimated)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- RCT-ERAS-2026-01
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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