Dexmedetomidine vs Lignocaine for Reducing Intubation-Induced Hemodynamic Responses in Cardiac Surgery: A Randomized Controlled Trial

Comparison of Intravenous Dexmedetomidine and Lignocaine in Reducing Hemodynamic Responses During Laryngoscopy and Endotracheal Intubation In Patients Undergoing Cardiac Surgery at Rawalpindi Institute Of Cardiology- A Randomized Controlled Trial

After confirming eligibility, written informed consent will be obtained by a trained team member who is not involved in assigning treatment or giving the study medication. Each participant will receive a unique study number to protect privacy. Participants will be randomly assigned to receive one of the study medications using a chance-based method.The study medication will be administered through a vein before placement of the breathing tube. Blood pressure and pulse rate will be measured before the procedure and at several time points after the breathing tube is inserted.

Study Overview

• Status: Recruiting
• Conditions: Dexmedetomidine; Lignocaine; Laryngoscopic Stress Response
• Intervention / Treatment: Drug: IV dexmedetomidine; Drug: IV Lignocaine

Detailed Description

After confirming eligibility, written informed consent will be obtained and each participant will be assigned a unique study ID to maintain confidentiality. Participants will be randomly allocated using a computer-generated random sequence implemented through the lottery method, with assignments placed in sealed opaque envelopes opened on the day of surgery. The study medication will be administered intravenously according to the study protocol before laryngoscopy and endotracheal intubation. Mean arterial pressure and heart rate will be recorded at baseline and at 1, 3, 5, and 10 minutes after intubation. Demographic information and study-related observations will be documented in a structured data collection form.

• Study Type: Interventional
• Enrollment (Estimated): 70
• Phase: Phase 4

Contacts and Locations

• Study Contact: Name: Namrah Zujaj, MBBS; Phone Number: +92 305 2636980; Email: zujajnamrah20@gmail.com

Study Locations

• Pakistan
  • Punjab Province
    • Rawalpindi, Punjab Province, Pakistan, 46000
      • Recruiting
      • Rawalpindi Institute of Cardiology
      • Contact: Asma Shabbir, MBBS,FCPS; Phone Number: +92 333 5161142; Email: Research@ricrwp.edu.pk

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

American Society of Anesthesiologists (ASA) physical status III-IV. Patients who are at risk of cardiovascular events

Exclusion Criteria:

1. Patients with known hypersensitivity to dexmedetomidine and Lignocaine.
2. Patients on medications that could interfere with the study (e.g., beta-blockers, calcium channel blockers).
3. Pregnant or lactating women.
4. Patients with a history of airway anomalies or difficult intubation.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Group Dexmed	Drug: IV dexmedetomidine; 0.5 Mcg/kg of Dexmedetomidine will be given 10 minutes before laryngoscopy
Active Comparator: Group Lignocaine	Drug: IV Lignocaine; Patients will be given 1.5 mg/kg of Lignocaine 3 minutes before laryngoscopy

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Mean Arterial Pressure	It will be expressed in millimeters of mercury (mmHg) and measured using an arterial catheter immediately before intubation and then at 1,3,5 and 10 minutes after intubation.
Heart Rate	It will be expressed as number of heart beats per minute and measured using pulse oximeter immediately before intubation and then at 1,3,5 and 10 minutes after intubation.

Collaborators and Investigators

• Sponsor: Rawalpindi Institute of Cardiology
• Investigators: Study Chair: Qudsia Anjum, MBBS,FCPS, Rawalpindi Institute of Cardiology

Publications and helpful links

General Publications

• Dube S, Gosavi K, Admane G. Comparative study of Dexmedetomidine, Lignocaine and their combination for the attenuation of hemodynamic response during laryngoscopy and intubation [Internet]. Indian J Clin Anaesth. 2022 [cited 2026 May 21];9(1):27-31. Available from: https://doi.org/10.18231/j.ijca.2022.007

Study record dates

Study Major Dates

• Study Start (Actual): May 21, 2026
• Primary Completion (Estimated): August 21, 2026
• Study Completion (Estimated): August 21, 2026

Study Registration Dates

• First Submitted: May 21, 2026
• First Submitted That Met QC Criteria: May 21, 2026
• First Posted (Actual): May 28, 2026

Study Record Updates

• Last Update Posted (Actual): May 28, 2026
• Last Update Submitted That Met QC Criteria: May 21, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Keywords: Dexmedetomidine; Cardiac surgery; Lignocaine; Laryngoscopic stress response
• Additional Relevant MeSH Terms: Organic Chemicals; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Azoles; Imidazoles; Anilides; Amides; Aniline Compounds; Amines; Acetanilides; Lidocaine; Dexmedetomidine
• Other Study ID Numbers: RIC/RERC/13/25

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Hospital Ethical Committee doesnt allow

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No