Different Treatment Options For Mature Teeth With Apical Periodontitis

July 11, 2026 updated by: Sara Tariq Elemam

A Comparison Between Different Treatment Options For Mature Teeth With Apical Periodontitis: A Randomized Control Trial

A randomized control trial which aim to compare the healing potential for the following treatment options for mature teeth with apical periodontitis:

Group I: Conventional root canal treatment (CRT) Group II: Regenerative endodontic treatment (RET) using a blood clot scaffold Group III: RET using a blood clot scaffold loaded with recombinant human BMPs (rhBMPs)

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Cairo, Egypt
        • Faculty of dentistry ain shams university

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Patients aged 18-30 years
  • Healthy patients with no systemic diseases or known allergic reactions
  • Mature permanent molars diagnosed with pulp necrosis
  • Presence of a medium sized periapical lesion confirmed clinically and radiographically (PAI=3,4,5)

Exclusion Criteria:

  • Patients with generalized chronic periodontitis
  • Presence of small periapical lesions (PAI=1,2)
  • Periodontal pockets > 3 mm
  • Presence of systemic diseases or known hypersensitivity to any material used in the study

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Conventional RCT
Procedure: root canal treatment and intracanal medicament
conventional root canal treatment with obturation
Experimental: RET using a BMPs
Procedure: Regeneration with BMPs
RET using a blood clot scaffold loaded with recombinant human BMPs (rhBMPs)
Experimental: Regenerative endodontic treatment
Procedure: Regeneration
Regeneration using induction of bleeding

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Healing in terms of volumetric change of lesion anlayized by CBCT
Time Frame: 1 year
1 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sara Tariq Elemam

Investigators

  • Study Director: Shehab El Din Mohamed Saber, PHD, Faculty of dentistry ain shams university

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 1, 2021

Primary Completion (Actual)

April 1, 2026

Study Completion (Actual)

April 1, 2026

Study Registration Dates

First Submitted

July 1, 2026

First Submitted That Met QC Criteria

July 11, 2026

First Posted (Actual)

July 14, 2026

Study Record Updates

Last Update Posted (Actual)

July 14, 2026

Last Update Submitted That Met QC Criteria

July 11, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • ID-0917

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

Yes

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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