Role Of Fixed Prosthodontic Restorations on Metabolic Control of Ischemic Heart Disease Patients

July 10, 2026 updated by: Dr. Moaz Mohamed

Effect of Fixed Prosthodontic Rehabilitation on Nutritional and Metabolic Parameters in Patients With Ischemic Heart Disease

This study evaluated the effect of fixed prosthodontic rehabilitation on metabolic parameters and masticatory efficiency in patients with ischemic heart disease. Clinical and laboratory outcomes was assessed before and after treatment.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

90

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Tanta, Egypt
        • Faculty of Medicine

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

inclusion criteria

  • Patients aged 45 to 70 years with diagnosed stable ischemic heart disease.
  • Patients presenting with partial edentulism and compromised masticatory function due to missing teeth.
  • Patients indicated for fixed prosthodontic rehabilitation.
  • Patients with complete clinical records and laboratory data available at baseline and 6 months after treatment.
  • Patients who provided informed consent for treatment and use of their clinical data.

Exclusion criteria

  • uncontrolled systemic diseases affecting metabolic status (e.g., uncontrolled diabetes mellitus).
  • acute cardiovascular events or unstable ischemic heart disease.
  • Patients with conditions affecting oral function other than tooth loss (e.g., neuromuscular disorders).
  • Patients who received removable prostheses instead of fixed prosthodontic rehabilitation.
  • Patients with incomplete clinical records or missing baseline or 6-month laboratory data.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Fixed Prosthodontic Rehabilitation
Placement of fixed prosthodontic restorations to replace missing teeth and improve masticatory function in patients with ischemic heart disease.
Procedure: Fixed Prosthodontic Rehabilitation
Placement of fixed prosthodontic restorations to replace missing teeth and improve masticatory function.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in Hemoglobin A1c (HbA1c)
Time Frame: Baseline and 6 months after fixed prosthodontic rehabilitation
Hemoglobin A1c (HbA1c) (%) measured using standard laboratory methods. The mean change in HbA1c from baseline to 6 months after fixed prosthodontic rehabilitation will be assessed.
Baseline and 6 months after fixed prosthodontic rehabilitation
Change in High-Density Lipoprotein Cholesterol (HDL-C)
Time Frame: Baseline and 6 months after fixed prosthodontic rehabilitation
High-density lipoprotein cholesterol (HDL-C) concentration (mg/dL) measured using standard laboratory blood analysis. The mean change in HDL-C from baseline to 6 months after fixed prosthodontic rehabilitation will be assessed.
Baseline and 6 months after fixed prosthodontic rehabilitation
Change in Low-Density Lipoprotein Cholesterol (LDL-C)
Time Frame: Baseline and 6 months after fixed prosthodontic rehabilitation
Low-density lipoprotein cholesterol (LDL-C) concentration (mg/dL) measured using standard laboratory blood analysis. The mean change in LDL-C from baseline to 6 months after fixed prosthodontic rehabilitation will be assessed.
Baseline and 6 months after fixed prosthodontic rehabilitation

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Dr. Moaz Mohamed

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2024

Primary Completion (Actual)

September 12, 2025

Study Completion (Actual)

November 30, 2025

Study Registration Dates

First Submitted

July 6, 2026

First Submitted That Met QC Criteria

July 10, 2026

First Posted (Actual)

July 15, 2026

Study Record Updates

Last Update Posted (Actual)

July 15, 2026

Last Update Submitted That Met QC Criteria

July 10, 2026

Last Verified

July 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Tanta-Dent-Cardio-2026-01

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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