Clinical Application of FAP-Targeted Radionuclide Imaging in the Diagnosis and Staging of Malignant Solid Tumors

This study is a single-center, open-label first-in-human clinical study. Patients with clinically suspected or confirmed malignant solid tumors will undergo [68Ga]Ga-FAP PET imaging or [177Lu]Lu-FAP SPECT imaging as well as [18F]FDG PET imaging to determine the presence or absence of lesions, and to assess lesion location, characteristics, and metastasis. Histopathological diagnosis or follow-up results will serve as the reference standard. The diagnostic efficacy of [68Ga]Ga-FAP PET imaging or [177Lu]Lu-FAP SPECT imaging for malignant tumors will be evaluated. Additionally, the study will analyze the biodistribution and dosimetry of [177Lu]Lu-FAP following a single administration, explore the correlation between tumor uptake values on imaging and immunohistochemical FAP expression levels, and evaluate the safety and tolerability of a single low-dose intravenous injection of [68Ga]Ga-FAP or [177Lu]Lu-FAP for diagnostic imaging.

Study Overview

• Status: Not yet recruiting
• Conditions: Malignant Neoplasm
• Intervention / Treatment: Drug: Novel FAP-targeted probe

• Study Type: Interventional
• Enrollment (Estimated): 20
• Phase: Early Phase 1

Contacts and Locations

• Study Contact: Name: Xiaoli Lan, PhD; Phone Number: 0086-027-83692633; Email: lxl730724@hotmail.com

Study Locations

• China
  • Hubei
    • Wuhan, Hubei, China
      • Wuhan union hosptital
      • Contact: Xiaoli Lan, PhD; Phone Number: +86-027-83692633; Email: lxl730724@hotmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

1. Voluntary participation and the patient or their legal representative is able to sign an informed consent form.
2. Adult patients (aged 18 or above), regardless of gender.
3. Patients with an ECOG performance status of 0 to 1 and able to tolerate PET and SPECT/CT examinations.
4. Patients with histopathologically or clinically confirmed malignant solid tumors who have measurable lesions according to RECIST 1.1 criteria.
5. Patients with expected survival>6 months.
6. Female patients of childbearing potential must have a negative pregnancy test, and all patients (including male patients) agree to use effective contraceptive measures during the study period and for at least three months after study drug administration.

Exclusion Criteria:

1. Patients who are pregnant or breastfeeding, or plan to become pregnant during the study period or within three months after study drug administration (excluding those who have been postmenopausal for at least one year, or those who are surgically sterilized, such as bilateral tubal ligation without recanalization, bilateral oophorectomy, or hysterectomy); or patients who plan to donate sperm or eggs during the study period or within three months after study drug administration.
2. Patients with known or suspected allergy to the investigational drug or any of its components, or patients with severe allergic constitution.
3. Patients who have undergone procedures within 6 months prior to study entry that, in the investigator's judgment, may affect drug absorption, distribution, metabolism, or excretion.
4. Patients with positive syphilis or HIV test results at screening.
5. Patients with abnormal liver or kidney function: serum total bilirubin (TBIL) > 31.5 umol/L; aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 120 U/L, or > 200 U/L if the elevation is considered to be related to liver metastases from solid tumors; serum creatinine (Scr) > 150 umol/L, or creatinine clearance < 60 mL/min (according to the Cockcroft-Gault formula).
6. Patients with abnormal bone marrow parameters: absolute neutrophil count < 1.5 x 10^9/L, hemoglobin < 10 g/dL, serum albumin < 2.8 g/dL (normal range 3.5-5.5 g/dL), platelets < 100 x 10^9/L (normal range 100-300 x 10^9/L), international normalized ratio (INR) > 1.5 (normal range 0.8-1.3) in patients not taking warfarin, or prothrombin time (PT) > 2 x ULN (normal range 11-15 seconds).
7. Patients with active infection (e.g., acute bacterial infection, tuberculosis, active hepatitis B/C, active syphilis, etc.). Active hepatitis B is defined as: positive HBsAg or HBcAb, or results outside the normal reference range, accompanied by hepatitis B virus DNA titer > 2500 copies/mL or > 500 IU/mL. Active hepatitis C is defined as: positive hepatitis C antibody, or results outside the normal reference range, and positive HCV-RNA.
8. Patients with dysuria or urinary incontinence due to any cause.
9. Patients with claustrophobia or other conditions that preclude cooperation with PET/MR and SPECT/CT examinations.
10. Patients with psychiatric disorders such as depressive symptoms, schizophrenia, delusions, hallucinations, or suicidal ideation.
11. Patients with severe cardiovascular disease, including but not limited to New York Heart Association (NYHA) class II to IV congestive heart failure, or left ventricular ejection fraction (LVEF) < 50% or below the lower limit of normal.
12. Patients with other conditions that, in the investigator's opinion, make the patient unsuitable for participation in this study.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Diagnostic
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

Experimental: PET/SPECT imaging of novel FAP-targeted probe in malignant neoplasm; This project aims to perform integrated SPECT/CT or PET/MR imaging in patients with histologically confirmed malignant neoplasms with high fibroblast activation protein (FAP) expression. This study utilizes a FAP-specific PET/SPECT imaging probe to evaluate the feasibility, accuracy, and clinical value in malignant neoplasm.

Drug: Novel FAP-targeted probe; For Cancer patients, subjects should have targeting FAP scans

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Visual and standardized uptake values assessment of lesions and biodistribution	At least two experienced nuclear medicine physicians will analyze the images, using histopathological diagnosis or follow-up findings as the reference standard.The standardized uptake value (SUV) of tumor and organs will be measured after a semiquantitative analysis is conducted for each case.	1 month

Collaborators and Investigators

• Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Study record dates

Study Major Dates

• Study Start (Estimated): July 30, 2026
• Primary Completion (Estimated): September 30, 2026
• Study Completion (Estimated): December 30, 2026

Study Registration Dates

• First Submitted: April 14, 2026
• First Submitted That Met QC Criteria: July 12, 2026
• First Posted (Actual): July 16, 2026

Study Record Updates

• Last Update Posted (Actual): July 16, 2026
• Last Update Submitted That Met QC Criteria: July 12, 2026
• Last Verified: July 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neoplasms
• Other Study ID Numbers: Xlan-20251286

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No