Salivary Cytokines, MMP-8 and Dental Caries in Osteoporosis Patients

July 12, 2026 updated by: Kübra Karaçam, Afyonkarahisar Health Sciences University

Osteoporoz Hastalarında Tükürük Sitokin, Matrix Metalloproteinase 8 ve Diş Çürüğünün Değerlendirilmesi

This study examines saliva samples from patients with osteoporosis. The levels of cytokines and Matrix Metalloproteinase-8 (MMP-8) enzyme in saliva will be measured. Additionally, the dental caries status of participants will be evaluated. The aim of this study is to understand the relationship between osteoporosis and oral health. Only saliva samples will be collected from participants; no treatment or medication will be administered.

Study Overview

Status

Not yet recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

50

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

Patients diagnosed with osteoporosis who applied to the outpatient clinic. Saliva samples and dental caries status will be evaluated. Participants will be selected according to inclusion and exclusion criteria.

Description

Inclusion Criteria:

  • Willing to give voluntary consent For Group 1, having been diagnosed with osteoporosis For Group 2, being systemically healthy and not having a diagnosis of osteoporosis/osteopenia

Exclusion Criteria:

  • Having a chronic inflammatory or autoimmune disease Using glucocorticoids, anti-anxiety medications, antidepressants, or antiepileptic drugs Having been diagnosed with any malignancy Having any endocrine disease Having undergone periodontal treatment within the last 6 months

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Osteoporosis Group
Patients diagnosed with osteoporosis. Saliva samples will be collected to measure cytokine levels and MMP-8.
Control Group
Healthy individuals without osteoporosis. Saliva samples will be collected for comparison.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Salivary Cytokine Levels
Time Frame: day 1
Measurement of cytokine levels in saliva samples collected from osteoporosis patients
day 1

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Afyonkarahisar Health Sciences University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

July 10, 2026

Primary Completion (Estimated)

September 30, 2026

Study Completion (Estimated)

July 10, 2027

Study Registration Dates

First Submitted

July 12, 2026

First Submitted That Met QC Criteria

July 12, 2026

First Posted (Actual)

July 16, 2026

Study Record Updates

Last Update Posted (Actual)

July 16, 2026

Last Update Submitted That Met QC Criteria

July 12, 2026

Last Verified

July 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2026/476

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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