Knowledge of Inborn Errors of Immunity Among Pediatric Physicians

September 23, 2026 updated by: Loay Salah Sodky, Assiut University

Assessment of Knowledge Regarding Inborn Errors of Immunity Among Pediatric Physicians in Assiut: A Cross-Sectional Study

This cross-sectional study aims to assess the level of knowledge regarding inborn errors of immunity among pediatric physicians working in Assiut Governorate, Egypt.

Study Overview

Status

Not yet recruiting

Conditions

Primary Immunodeficiency Diseases

Detailed Description

Inborn errors of immunity (IEI) are heterogeneous disorders that can present with recurrent, severe, or unusual infections, autoimmunity, and other manifestations. Early recognition by pediatric physicians is important for timely diagnosis and management.

This observational study will use a self-administered electronic questionnaire to assess knowledge of clinical warning signs, general and specific signs of IEI, and treatment and immunization strategies among pediatric physicians in Assiut.

Study Type

Observational

Enrollment (Estimated)

347

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Loay s sedky, Resident
Phone Number: +20 12 02936248
Email: Loay.17289948@med.aun.edu.eg

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

24 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Pediatric physicians working in participating hospitals in Assiut Governorate, Egypt.

Description

Inclusion Criteria:

- Working as a pediatric physician in Assiut
Practicing pediatrics in a participating hospital
Willing to participate and able to complete the electronic questionnaire
Providing informed consent

Exclusion Criteria:

- Refusal to participate
Inadequate or substantially incomplete questionnaire response
Not currently practicing pediatrics
Participation in questionnaire development or validation

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Observational Models: CASE_ONLY
Time Perspectives: CROSS_SECTIONAL

Number of groups / cohorts

Cohorts and Interventions

Group / Cohort
Single cohort: Pediatric physicians Pediatric physicians working in Assiut who will complete a self-administered electronic questionnaire assessing knowledge of inborn errors of immunity.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Overall knowledge score regarding inborn errors of immunity Time Frame: Baseline	Mean percentage score of correct answers on the knowledge questionnaire regarding inborn errors of immunity (maximum score expressed as percentage) Score ranges from 0 to 100%, with higher scores indicating better knowledge.	Baseline

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Domain-Specific Knowledge Scores Time Frame: Baseline	Separate percentage scores for four domains: 1) Warning signs in children (4 questions) and adults (2 questions), 2) General signs of IEI (5 questions), 3) Specific signs of IEI (9 questions), 4) Treatment strategies and immunization (5 questions) Score ranges from 0 to 100%, with higher scores indicating better knowledge.	Baseline
Knowledge scores according to professional and educational characteristics Time Frame: Baseline	Mean overall knowledge scores stratified by years of experience, educational level, hospital affiliation type, previous training in pediatric immunology, and daily case flow.Score ranges from 0 to 100%, with higher scores indicating better knowledge.	Baseline
Mean knowledge scores by hospital Time Frame: Baseline	Comparison of mean overall knowledge scores across participating hospitals in Assiut Governorate to identify hospitals with greatest knowledge gaps requiring priority targeted educational and training activities. Interpreted in relation to number of participating physicians per hospital.Score ranges from 0 to 100%, with higher scores indicating better knowledge.	Baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Investigators

Study Chair: Mustafa M Embaby, prof, Pediatrics Hematology department Faculty of Medicine, Assiut University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

September 20, 2026

Primary Completion (Estimated)

September 20, 2027

Study Completion (Estimated)

March 10, 2028

Study Registration Dates

First Submitted

September 18, 2026

First Submitted That Met QC Criteria