Mapping Recovery, Quality of Life, and Physical Function After Partial and Radical Nephrectomy

Aim:

To investigate recovery, quality of life, and physical function before and after partial or radical nephrectomy.

To validate the Quality of Recovery-15 (QoR-15) questionnaire in a urological cohort and investigate whether the questionnaire can be used to identify differences in patient-reported recovery across patient populations.

Study Overview

• Status: Recruiting
• Conditions: Nephrectomy; Nephrectomy / Methods
• Intervention / Treatment: Other: None, observational study

• Study Type: Observational
• Enrollment (Estimated): 150

Contacts and Locations

Study Locations

• Denmark
  • Herlev, Denmark, 2730
    • Recruiting
    • Department of Urology, Copenhagen University Hospital Herlev and Gentofte
    • Contact: Marie Juul-Haslund, MD; Phone Number: 004538682699; Email: marie.juul-haslund@regionh.dk

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

All patients >18 years scheduled for radical or partial nephrectomy

Description

Inclusion criteria

• Scheduled for radical or partial nephrectomy (all surgical approaches).
• Benign or malignant indication for surgery.
• Age >18 years. Exclusion criteria
• Unable to read Danish.
• Unable to complete the questionnaire.
• Emergency surgery.

Study Plan

How is the study designed?

Design Details

• Observational Models: COHORT
• Time Perspectives: PROSPECTIVE

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in quality of recovery from enrollment to outpatient follow-up 21 days after surgery	Quality of recovery is evaluated with the danish translation of the verified questionnaire Quality of Recovery-15. It is a 15-item patient questionnaire, where the score ranges from 0-150. A higher score indicates better patient-reported quality of recovery. QoR-15 will be assessed preoperatively, and 1, 2, 7 and 21 days after surgery. Change in QoR-15 from enrollment to 21 days after surgery is the primary outcome measure. Change in QoR-15 at other assessment times will be assessed as secondary outcome measures.	From enrollment to the end of follow up 21 days after surgery

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Quality of Recovery at other predefined time points.	Quality of recovery is measured by the danish translation of the verified questionnaire Quality of Recovery-15. It is a 15-item patient questionnaire, where the score ranges from 0-150. A higher score indicates better patient-reported quality of recovery. QoR-15 will be assessed at preoperatively, and 1, 2, 7 and 21 days after surgery.	Multiple times from enrollment to outpatient follow-up at 21 days after surgery
Change in quality of life assessed using the EQ-5D-5L	Quality of life is evaluated with the danish translation of the validated questionnaire EQ-5D-5L. The questionnaire evalutes five health dimensions (mobility, self-care, usual acitivites, pain/discomfort, anxiety/depression) ranging from "no problems" to "unable/ extreme problems". Additionally, it includes a visual analog scale scoring from 0-100, reflecting the participants overall self-reported health state. A higher score indicates a better patient-reported quality of life. Quality of life will be assessed preoperatively and 21 days after surgery.	From enrollment to the end of follow up 21 days after surgery
Physical function assessed using the 30 second sit to stand, handgrip strength and 6 minute walking test.	Physical function assessed using the 30 second sit to stand test (number of repetitions in 30s), handgrip strength test (maximum voluntary muscle strength in kg) and 6 minute walking test (distance in meters). The higher the test results, the better, for all tests. The tests are performed preoperatively and 21 days after surgery.	From enrollment to the end of follow up, 21 days after surgery
Validation parameters for the Quality of Recovery-15.	An evaluation of validity, reliability, responsiveness and feasibility of the Quality of Recovery-15, assessed preoperatively, and 1, 2, 7 and 21 days after surgery.	From enrollment to the end of follow up, 21 days after surgery

Collaborators and Investigators

• Sponsor: Herlev and Gentofte Hospital

Study record dates

Study Major Dates

• Study Start (Actual): October 22, 2026
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): January 31, 2028

Study Registration Dates

• First Submitted: October 22, 2026
• First Submitted That Met QC Criteria: October 28, 2026
• First Posted (Actual): November 2, 2026

Study Record Updates

• Last Update Posted (Actual): November 3, 2026
• Last Update Submitted That Met QC Criteria: October 30, 2026
• Last Verified: October 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Investigative Techniques; Methods; Observation
• Other Study ID Numbers: F-26022406

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO